ALDH1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.46496091
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46496091
3L-phenylalanine metabolic process (GO:0006558)7.14789189
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.14789189
5aromatic amino acid family catabolic process (GO:0009074)6.74996414
6epoxygenase P450 pathway (GO:0019373)6.61956960
7omega-hydroxylase P450 pathway (GO:0097267)6.38947455
8tryptophan catabolic process (GO:0006569)6.12513559
9indole-containing compound catabolic process (GO:0042436)6.12513559
10indolalkylamine catabolic process (GO:0046218)6.12513559
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03408381
12kynurenine metabolic process (GO:0070189)5.92492950
13glyoxylate metabolic process (GO:0046487)5.82643333
14bile acid biosynthetic process (GO:0006699)5.79531992
15tryptophan metabolic process (GO:0006568)5.76003331
16alpha-linolenic acid metabolic process (GO:0036109)5.62682308
17cysteine metabolic process (GO:0006534)5.61162328
18ethanol metabolic process (GO:0006067)5.57005754
19urea metabolic process (GO:0019627)5.55805758
20urea cycle (GO:0000050)5.55805758
21sulfur amino acid catabolic process (GO:0000098)5.48128743
22high-density lipoprotein particle remodeling (GO:0034375)5.24060657
23serine family amino acid catabolic process (GO:0009071)5.21653189
24negative regulation of fibrinolysis (GO:0051918)5.20943237
25nitrogen cycle metabolic process (GO:0071941)5.11638373
26complement activation, alternative pathway (GO:0006957)5.09156168
27drug metabolic process (GO:0017144)5.06662072
28regulation of protein activation cascade (GO:2000257)5.04495684
29peptidyl-glutamic acid carboxylation (GO:0017187)5.04048778
30protein carboxylation (GO:0018214)5.04048778
31homocysteine metabolic process (GO:0050667)5.03367671
32regulation of fibrinolysis (GO:0051917)5.01328733
33lysine catabolic process (GO:0006554)4.95669886
34lysine metabolic process (GO:0006553)4.95669886
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95661245
36bile acid metabolic process (GO:0008206)4.95259269
37aromatic amino acid family metabolic process (GO:0009072)4.89854230
38regulation of complement activation (GO:0030449)4.71917813
39amino-acid betaine metabolic process (GO:0006577)4.70485101
40tyrosine metabolic process (GO:0006570)4.69732957
41* alpha-amino acid catabolic process (GO:1901606)4.65617822
42oxidative demethylation (GO:0070989)4.64777874
43reverse cholesterol transport (GO:0043691)4.64707554
44regulation of cholesterol esterification (GO:0010872)4.63943861
45regulation of triglyceride catabolic process (GO:0010896)4.60851994
46protein-lipid complex remodeling (GO:0034368)4.55280159
47macromolecular complex remodeling (GO:0034367)4.55280159
48plasma lipoprotein particle remodeling (GO:0034369)4.55280159
49cellular ketone body metabolic process (GO:0046950)4.41683502
50negative regulation of cholesterol transport (GO:0032375)4.40452410
51negative regulation of sterol transport (GO:0032372)4.40452410
52triglyceride homeostasis (GO:0070328)4.39036376
53acylglycerol homeostasis (GO:0055090)4.39036376
54glutamate metabolic process (GO:0006536)4.38423167
55* cellular amino acid catabolic process (GO:0009063)4.33535232
56glycine metabolic process (GO:0006544)4.32805457
57indolalkylamine metabolic process (GO:0006586)4.31827120
58phospholipid efflux (GO:0033700)4.29699906
59serine family amino acid metabolic process (GO:0009069)4.28618815
60cellular biogenic amine catabolic process (GO:0042402)4.24658727
61amine catabolic process (GO:0009310)4.24658727
62cellular glucuronidation (GO:0052695)4.23291945
63bile acid and bile salt transport (GO:0015721)4.20007936
64plasma lipoprotein particle clearance (GO:0034381)4.19127278
65ethanol oxidation (GO:0006069)4.16401813
66drug catabolic process (GO:0042737)4.15752224
67imidazole-containing compound metabolic process (GO:0052803)4.14592787
68serine family amino acid biosynthetic process (GO:0009070)4.11745127
69benzene-containing compound metabolic process (GO:0042537)4.10901531
70dicarboxylic acid biosynthetic process (GO:0043650)4.09008299
71S-adenosylmethionine metabolic process (GO:0046500)3.98167784
72low-density lipoprotein particle remodeling (GO:0034374)3.98096509
73* cellular modified amino acid catabolic process (GO:0042219)3.97432958
74arginine metabolic process (GO:0006525)3.96496135
75cholesterol efflux (GO:0033344)3.96177164
76short-chain fatty acid metabolic process (GO:0046459)3.91313332
77acetyl-CoA metabolic process (GO:0006084)3.87642145
78aldehyde catabolic process (GO:0046185)3.86850015
79protein activation cascade (GO:0072376)3.84272724
80plasma lipoprotein particle assembly (GO:0034377)3.83925253
81alkaloid metabolic process (GO:0009820)3.83865227
82ketone body metabolic process (GO:1902224)3.83179737
83phenylpropanoid metabolic process (GO:0009698)3.80743787
84* organic acid catabolic process (GO:0016054)3.80042037
85* carboxylic acid catabolic process (GO:0046395)3.80042037
86glucuronate metabolic process (GO:0019585)3.78733339
87uronic acid metabolic process (GO:0006063)3.78733339
88fibrinolysis (GO:0042730)3.74919490
89regulation of cholesterol homeostasis (GO:2000188)3.74574440
90fatty acid homeostasis (GO:0055089)3.71949188
91regulation of bile acid biosynthetic process (GO:0070857)3.71835343
92phospholipid homeostasis (GO:0055091)3.71701496
93response to mercury ion (GO:0046689)3.70979853
94exogenous drug catabolic process (GO:0042738)3.70802526
95aspartate family amino acid catabolic process (GO:0009068)3.70734116
96urate metabolic process (GO:0046415)3.69949583
97drug transmembrane transport (GO:0006855)3.67377099
98triglyceride catabolic process (GO:0019433)3.67011544
99xenobiotic catabolic process (GO:0042178)3.65109704
100negative regulation of protein activation cascade (GO:2000258)3.64923699
101regulation of plasminogen activation (GO:0010755)3.64309201
102oxaloacetate metabolic process (GO:0006107)3.64131097
1032-oxoglutarate metabolic process (GO:0006103)3.63344671
104very-low-density lipoprotein particle assembly (GO:0034379)3.62844610
105cholesterol homeostasis (GO:0042632)3.61826755
106daunorubicin metabolic process (GO:0044597)3.60252050
107polyketide metabolic process (GO:0030638)3.60252050
108doxorubicin metabolic process (GO:0044598)3.60252050
109positive regulation of lipid catabolic process (GO:0050996)3.59475398
110* coenzyme catabolic process (GO:0009109)3.58380886
111sterol homeostasis (GO:0055092)3.56690953
112flavonoid metabolic process (GO:0009812)3.56108889
113blood coagulation, intrinsic pathway (GO:0007597)3.54476618
114complement activation, classical pathway (GO:0006958)3.53726971
115positive regulation of lipoprotein lipase activity (GO:0051006)3.52874520
116positive regulation of triglyceride lipase activity (GO:0061365)3.52874520
117complement activation (GO:0006956)3.52700001
118monocarboxylic acid catabolic process (GO:0072329)3.52671118
119negative regulation of lipase activity (GO:0060192)3.51844113
120acylglycerol catabolic process (GO:0046464)3.51658604
121neutral lipid catabolic process (GO:0046461)3.51658604
122primary alcohol metabolic process (GO:0034308)3.48476224
123biotin metabolic process (GO:0006768)3.48076030
124primary alcohol catabolic process (GO:0034310)3.40558234
125negative regulation of hemostasis (GO:1900047)3.39756076
126negative regulation of blood coagulation (GO:0030195)3.39756076
127intestinal cholesterol absorption (GO:0030299)3.37109035
128regulation of humoral immune response (GO:0002920)3.36514316
129regulation of sequestering of triglyceride (GO:0010889)3.35996612
130acute-phase response (GO:0006953)3.35042252
131aminoglycoside antibiotic metabolic process (GO:0030647)3.27898000
132fatty acid transmembrane transport (GO:1902001)3.26494730
133opsonization (GO:0008228)3.22102413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.21647190
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.02461595
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.64315027
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.39053883
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.14377310
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10907878
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.79229988
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99049495
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78467280
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12047357
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10400129
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6873979
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96343183
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94544539
15EZH2_22144423_ChIP-Seq_EOC_Human1.74926994
16GBX2_23144817_ChIP-Seq_PC3_Human1.71034251
17CLOCK_20551151_ChIP-Seq_293T_Human1.70348159
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.63731798
19HTT_18923047_ChIP-ChIP_STHdh_Human1.45429653
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41527498
21DROSHA_22980978_ChIP-Seq_HELA_Human1.41273234
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.34758088
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33063248
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21995310
25GATA1_22025678_ChIP-Seq_K562_Human1.21602432
26IGF1R_20145208_ChIP-Seq_DFB_Human1.16697675
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16130104
28RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14525185
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09940355
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07391422
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03478165
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01825583
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01117682
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00205293
35* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98712588
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98676084
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96597332
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96582644
39ER_23166858_ChIP-Seq_MCF-7_Human0.95783858
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94955712
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93648904
42NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92835398
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92233493
44* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91029672
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90705463
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89762691
47MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89477530
48KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89463399
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89312943
50STAT3_23295773_ChIP-Seq_U87_Human0.88314001
51EP300_21415370_ChIP-Seq_HL-1_Mouse0.86713202
52ESR2_21235772_ChIP-Seq_MCF-7_Human0.85842142
53GATA4_25053715_ChIP-Seq_YYC3_Human0.85815849
54SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85114333
55NFE2_27457419_Chip-Seq_LIVER_Mouse0.84586920
56AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83682915
57* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82905702
58TCF4_23295773_ChIP-Seq_U87_Human0.82382369
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82325336
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82027724
61EZH2_27294783_Chip-Seq_ESCs_Mouse0.81226278
62REST_21632747_ChIP-Seq_MESCs_Mouse0.79657677
63AR_25329375_ChIP-Seq_VCAP_Human0.78806785
64CBP_20019798_ChIP-Seq_JUKART_Human0.78604114
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78604114
66SMAD4_21799915_ChIP-Seq_A2780_Human0.78327538
67REST_18959480_ChIP-ChIP_MESCs_Mouse0.77566180
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77309023
69CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76718556
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76574195
71VDR_22108803_ChIP-Seq_LS180_Human0.76241050
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75924091
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75800323
74* SOX2_21211035_ChIP-Seq_LN229_Human0.75696628
75CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75519919
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75398614
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75280944
78* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74393173
79CDX2_22108803_ChIP-Seq_LS180_Human0.74370938
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.74216432
81NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72868128
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.72862319
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72776342
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72279125
85ZNF263_19887448_ChIP-Seq_K562_Human0.71561984
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71363162
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.71123092
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71057368
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70923699
90* TBX20_22328084_ChIP-Seq_HEART_Mouse0.70733737
91* TBX20_22080862_ChIP-Seq_HEART_Mouse0.70733737
92MYC_19829295_ChIP-Seq_ESCs_Human0.70668814
93* SOX2_19829295_ChIP-Seq_ESCs_Human0.70388987
94* NANOG_19829295_ChIP-Seq_ESCs_Human0.70388987
95PHF8_20622853_ChIP-Seq_HELA_Human0.70117225
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70117106
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70034829
98TP53_18474530_ChIP-ChIP_U2OS_Human0.69663072
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69393068
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.69269752
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69260001
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69260001
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68108559
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67852912
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66975134
106LXR_22292898_ChIP-Seq_THP-1_Human0.64924375
107IRF8_22096565_ChIP-ChIP_GC-B_Human0.64382983
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63230826
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62195098
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.60608509
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.60204605
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.60115002
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.57764218
114CEBPB_22108803_ChIP-Seq_LS180_Human0.56564443
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54735389
116EGR1_19032775_ChIP-ChIP_M12_Human0.54414545
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53746384
118MYC_19915707_ChIP-ChIP_AK7_Human0.53683154
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53627292
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.52938962
121AR_20517297_ChIP-Seq_VCAP_Human0.52684819
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52357172
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.51302097
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50482830
125CBP_21632823_ChIP-Seq_H3396_Human0.49867444
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.49251259
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.49162622
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48314237
129BCAT_22108803_ChIP-Seq_LS180_Human0.47676334
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46467841
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.45494260
132* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45364346
133STAT1_17558387_ChIP-Seq_HELA_Human0.45361350
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.45041289
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45029415
136GATA1_19941826_ChIP-Seq_K562_Human0.43380587
137GATA2_19941826_ChIP-Seq_K562_Human0.42950808
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42946347
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.42846816
140* P53_21459846_ChIP-Seq_SAOS-2_Human0.42661685
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.42625456
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.41597150
143* TAF2_19829295_ChIP-Seq_ESCs_Human0.41507725
144GATA6_25053715_ChIP-Seq_YYC3_Human0.40984755
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40678053
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39165901
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38384793
148TRIM28_21343339_ChIP-Seq_HEK293_Human0.37227030
149GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37109166
150SOX2_20726797_ChIP-Seq_SW620_Human0.36991475
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36757591
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36675170
153TAF15_26573619_Chip-Seq_HEK293_Human0.36351419
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36126958
155ERG_20517297_ChIP-Seq_VCAP_Human0.36003716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14168270
2MP0005360_urolithiasis7.72892804
3MP0005085_abnormal_gallbladder_physiolo6.24049695
4MP0005365_abnormal_bile_salt6.07003817
5MP0008875_abnormal_xenobiotic_pharmacok5.12058562
6MP0003806_abnormal_nucleotide_metabolis4.08199198
7MP0003252_abnormal_bile_duct3.82974752
8MP0010329_abnormal_lipoprotein_level3.56055582
9MP0009840_abnormal_foam_cell3.19540488
10MP0005332_abnormal_amino_acid3.03145395
11MP0005083_abnormal_biliary_tract2.98317730
12MP0003195_calcinosis2.88642556
13MP0001666_abnormal_nutrient_absorption2.62024419
14MP0004019_abnormal_vitamin_homeostasis2.37836469
15MP0003191_abnormal_cellular_cholesterol2.27187530
16MP0002118_abnormal_lipid_homeostasis2.13145147
17MP0000609_abnormal_liver_physiology2.11653142
18MP0002138_abnormal_hepatobiliary_system1.98206105
19MP0005319_abnormal_enzyme/_coenzyme1.84195466
20MP0003868_abnormal_feces_composition1.83711651
21MP0003646_muscle_fatigue1.66518944
22MP0005584_abnormal_enzyme/coenzyme_acti1.64732991
23MP0001764_abnormal_homeostasis1.63972695
24MP0009643_abnormal_urine_homeostasis1.42682630
25MP0003011_delayed_dark_adaptation1.41514830
26MP0003879_abnormal_hair_cell1.38504979
27MP0009697_abnormal_copulation1.37183453
28MP0003186_abnormal_redox_activity1.36588934
29MP0005451_abnormal_body_composition1.32882344
30MP0001984_abnormal_olfaction1.27766340
31MP0000751_myopathy1.25721051
32MP0004145_abnormal_muscle_electrophysio1.19767382
33MP0003705_abnormal_hypodermis_morpholog1.19523128
34MP0002254_reproductive_system_inflammat1.15804436
35MP0000598_abnormal_liver_morphology1.13459970
36MP0005647_abnormal_sex_gland1.11433806
37MP0000604_amyloidosis1.11193095
38MP0003656_abnormal_erythrocyte_physiolo1.11002428
39MP0005670_abnormal_white_adipose1.10430965
40MP0009780_abnormal_chondrocyte_physiolo1.10022878
41MP0005636_abnormal_mineral_homeostasis1.06643130
42MP0009764_decreased_sensitivity_to1.03917807
43MP0000749_muscle_degeneration1.01741629
44MP0005375_adipose_tissue_phenotype1.00731114
45MP0002638_abnormal_pupillary_reflex0.97069533
46MP0009763_increased_sensitivity_to0.94627443
47MP0004036_abnormal_muscle_relaxation0.90507617
48MP0005551_abnormal_eye_electrophysiolog0.90315978
49MP0002332_abnormal_exercise_endurance0.89653795
50MP0009642_abnormal_blood_homeostasis0.87403436
51MP0002876_abnormal_thyroid_physiology0.87396908
52MP0005423_abnormal_somatic_nervous0.87298074
53MP0003690_abnormal_glial_cell0.86224971
54MP0001501_abnormal_sleep_pattern0.85301198
55MP0006036_abnormal_mitochondrial_physio0.83928169
56MP0008469_abnormal_protein_level0.83618620
57MP0004130_abnormal_muscle_cell0.82394045
58MP0005084_abnormal_gallbladder_morpholo0.81874243
59MP0002078_abnormal_glucose_homeostasis0.79809619
60MP0002971_abnormal_brown_adipose0.79653598
61MP0004215_abnormal_myocardial_fiber0.79347711
62MP0010368_abnormal_lymphatic_system0.79308070
63MP0003329_amyloid_beta_deposits0.78458244
64MP0005535_abnormal_body_temperature0.77784257
65MP0004270_analgesia0.77479859
66MP0001756_abnormal_urination0.77012516
67MP0009745_abnormal_behavioral_response0.76825282
68MP0003959_abnormal_lean_body0.76595776
69MP0003633_abnormal_nervous_system0.76417904
70MP0005408_hypopigmentation0.76282508
71MP0006138_congestive_heart_failure0.76252717
72MP0005376_homeostasis/metabolism_phenot0.76142073
73MP0001486_abnormal_startle_reflex0.76140776
74MP0002132_abnormal_respiratory_system0.74673871
75MP0009765_abnormal_xenobiotic_induced0.73228620
76MP0002064_seizures0.72858405
77MP0005220_abnormal_exocrine_pancreas0.72831260
78MP0005646_abnormal_pituitary_gland0.72662831
79MP0005452_abnormal_adipose_tissue0.72400888
80MP0005334_abnormal_fat_pad0.71487010
81MP0001661_extended_life_span0.71365175
82MP0003880_abnormal_central_pattern0.68987329
83MP0001986_abnormal_taste_sensitivity0.68426242
84MP0002272_abnormal_nervous_system0.67355075
85MP0002909_abnormal_adrenal_gland0.66907265
86MP0002269_muscular_atrophy0.61668057
87MP0005266_abnormal_metabolism0.61104798
88MP0002736_abnormal_nociception_after0.60733741
89MP0002136_abnormal_kidney_physiology0.60511901
90MP0004087_abnormal_muscle_fiber0.58978920
91MP0001502_abnormal_circadian_rhythm0.58043057
92MP0005448_abnormal_energy_balance0.57851013
93MP0005666_abnormal_adipose_tissue0.57186981
94MP0001440_abnormal_grooming_behavior0.56857531
95MP0004185_abnormal_adipocyte_glucose0.56605199
96MP0009053_abnormal_anal_canal0.56130391
97MP0004043_abnormal_pH_regulation0.55493167
98MP0006035_abnormal_mitochondrial_morpho0.55176620
99MP0003631_nervous_system_phenotype0.54412562
100MP0000747_muscle_weakness0.53903692
101MP0001968_abnormal_touch/_nociception0.53873643
102MP0000639_abnormal_adrenal_gland0.53641436
103MP0005620_abnormal_muscle_contractility0.53383853
104MP0003638_abnormal_response/metabolism_0.52390201
105MP0005386_behavior/neurological_phenoty0.51523210
106MP0004924_abnormal_behavior0.51523210
107MP0003075_altered_response_to0.50965061
108MP0005395_other_phenotype0.48595005
109MP0002928_abnormal_bile_duct0.46893288
110MP0008874_decreased_physiological_sensi0.46304125
111MP0003953_abnormal_hormone_level0.45599195
112MP0002822_catalepsy0.45271407
113MP0008872_abnormal_physiological_respon0.43965407
114MP0005464_abnormal_platelet_physiology0.43357531
115MP0004782_abnormal_surfactant_physiolog0.42610650
116MP0009384_cardiac_valve_regurgitation0.42327345
117MP0005166_decreased_susceptibility_to0.40111024
118MP0009115_abnormal_fat_cell0.39581228
119MP0002168_other_aberrant_phenotype0.39128190
120MP0008873_increased_physiological_sensi0.38156978
121MP0000230_abnormal_systemic_arterial0.38126937
122MP0001765_abnormal_ion_homeostasis0.37770698
123MP0005248_abnormal_Harderian_gland0.37600193
124MP0003718_maternal_effect0.36957626
125MP0002796_impaired_skin_barrier0.36800577
126MP0002837_dystrophic_cardiac_calcinosis0.36085997
127MP0005167_abnormal_blood-brain_barrier0.35867745
128MP0005058_abnormal_lysosome_morphology0.35493897
129MP0009672_abnormal_birth_weight0.35344950
130MP0003724_increased_susceptibility_to0.34400251
131MP0002970_abnormal_white_adipose0.33296564
132MP0000579_abnormal_nail_morphology0.32501058
133MP0001881_abnormal_mammary_gland0.29743697
134MP0003436_decreased_susceptibility_to0.29388694
135MP0000249_abnormal_blood_vessel0.28673290
136MP0001853_heart_inflammation0.28421512
137MP0004381_abnormal_hair_follicle0.28238222
138MP0002090_abnormal_vision0.27786433
139MP0002135_abnormal_kidney_morphology0.27164025
140MP0004883_abnormal_blood_vessel0.25666349
141MP0005595_abnormal_vascular_smooth0.25071582

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.21707214
2Deep venous thrombosis (HP:0002625)7.02569108
3Intrahepatic cholestasis (HP:0001406)7.00892658
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46719334
5Xanthomatosis (HP:0000991)6.19965315
6Prolonged partial thromboplastin time (HP:0003645)6.13771455
7Hypobetalipoproteinemia (HP:0003563)6.06040892
8Hyperlipoproteinemia (HP:0010980)5.38443660
9Complement deficiency (HP:0004431)5.11890577
10Hyperammonemia (HP:0001987)4.72676558
11Hyperglycinemia (HP:0002154)4.62751838
12Hypolipoproteinemia (HP:0010981)4.60045155
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57403225
14Joint hemorrhage (HP:0005261)4.52703353
15Hyperglycinuria (HP:0003108)4.48858477
16Ketosis (HP:0001946)4.47918866
17Epidermoid cyst (HP:0200040)4.43481390
18Abnormality of glycine metabolism (HP:0010895)4.34404043
19Abnormality of serine family amino acid metabolism (HP:0010894)4.34404043
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.30907686
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23270507
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20155710
23Abnormality of the common coagulation pathway (HP:0010990)4.15640208
24Abnormality of methionine metabolism (HP:0010901)4.12407794
25Hypoalphalipoproteinemia (HP:0003233)4.07127740
26Fat malabsorption (HP:0002630)3.99030229
27Hypoglycemic coma (HP:0001325)3.81327338
28Abnormality of pyrimidine metabolism (HP:0004353)3.71498325
29Abnormality of complement system (HP:0005339)3.68579630
30Conjugated hyperbilirubinemia (HP:0002908)3.58164404
31Nephritis (HP:0000123)3.53106925
32Abnormality of the intrinsic pathway (HP:0010989)3.52609459
33Hypercholesterolemia (HP:0003124)3.50264150
34Abnormality of fatty-acid metabolism (HP:0004359)3.48510050
35Ketoacidosis (HP:0001993)3.35954218
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34080144
37Delayed CNS myelination (HP:0002188)3.28727482
38Abnormality of nucleobase metabolism (HP:0010932)3.23622185
39Hyperbilirubinemia (HP:0002904)3.22389048
40Abnormality of serum amino acid levels (HP:0003112)3.14702108
41Gout (HP:0001997)3.03941970
42Abnormality of purine metabolism (HP:0004352)2.99684116
43Steatorrhea (HP:0002570)2.97971897
44Hepatocellular carcinoma (HP:0001402)2.94423462
45Myocardial infarction (HP:0001658)2.89209773
46Metabolic acidosis (HP:0001942)2.86511651
47Exercise-induced myalgia (HP:0003738)2.81534300
48Spontaneous abortion (HP:0005268)2.77845033
49Skin nodule (HP:0200036)2.72227426
50Lethargy (HP:0001254)2.70307931
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69226332
52Dicarboxylic aciduria (HP:0003215)2.69226332
53Vascular calcification (HP:0004934)2.68973544
54Rhabdomyolysis (HP:0003201)2.68581690
55Systemic lupus erythematosus (HP:0002725)2.62681485
56Hypochromic microcytic anemia (HP:0004840)2.60722710
57Spastic diplegia (HP:0001264)2.58984623
58Acanthocytosis (HP:0001927)2.45230902
59Irritability (HP:0000737)2.45045519
60Myoglobinuria (HP:0002913)2.44389945
61Hypoglycemic seizures (HP:0002173)2.43705335
62Neonatal onset (HP:0003623)2.43256622
63Cerebral edema (HP:0002181)2.40685499
64Cardiovascular calcification (HP:0011915)2.38450073
65Mitral stenosis (HP:0001718)2.34681452
66Abnormal gallbladder morphology (HP:0012437)2.33703443
67Malnutrition (HP:0004395)2.33371155
68Increased serum pyruvate (HP:0003542)2.31872612
69Sensorimotor neuropathy (HP:0007141)2.28750934
70Alkalosis (HP:0001948)2.28668572
71Cholelithiasis (HP:0001081)2.27995035
72Muscle fiber inclusion bodies (HP:0100299)2.27083353
73Glomerulonephritis (HP:0000099)2.26593665
74Amyloidosis (HP:0011034)2.26040860
75Generalized aminoaciduria (HP:0002909)2.24668471
76Hydroxyprolinuria (HP:0003080)2.23396362
77Abnormality of proline metabolism (HP:0010907)2.23396362
78Enlarged kidneys (HP:0000105)2.22669099
79Cholecystitis (HP:0001082)2.21453828
80Abnormal gallbladder physiology (HP:0012438)2.21453828
81Vomiting (HP:0002013)2.21433296
82Late onset (HP:0003584)2.20495803
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19999728
84Abnormality of alanine metabolism (HP:0010916)2.19999728
85Hyperalaninemia (HP:0003348)2.19999728
86Pancreatitis (HP:0001733)2.17906347
87Esophageal varix (HP:0002040)2.17670815
88Atrioventricular block (HP:0001678)2.15616198
89Facial shape deformation (HP:0011334)2.14700469
90Potter facies (HP:0002009)2.14700469
91Abnormality of glycolysis (HP:0004366)2.14073654
92Nemaline bodies (HP:0003798)2.13179119
93Abnormality of vitamin metabolism (HP:0100508)2.12483842
94Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11335339
95Hyperuricemia (HP:0002149)2.09165518
96Increased purine levels (HP:0004368)2.09165518
97Recurrent gram-negative bacterial infections (HP:0005420)2.08686287
98Brushfield spots (HP:0001088)2.07853801
99Proximal tubulopathy (HP:0000114)2.07061126
100Fair hair (HP:0002286)2.04372651
101Rickets (HP:0002748)2.02511546
102Oligomenorrhea (HP:0000876)2.01532611
103Cerebral palsy (HP:0100021)2.00793125
104Thrombophlebitis (HP:0004418)1.97998656
105Opisthotonus (HP:0002179)1.97478615
106Hemorrhage of the eye (HP:0011885)1.96463924
107Gingival bleeding (HP:0000225)1.96413029
108Menorrhagia (HP:0000132)1.95485009
109Hyperinsulinemic hypoglycemia (HP:0000825)1.93658361
110Abnormality of the gallbladder (HP:0005264)1.92829523
111Heart block (HP:0012722)1.92345255
112Hypertriglyceridemia (HP:0002155)1.91978588
113Abnormal cartilage morphology (HP:0002763)1.91754120
114Status epilepticus (HP:0002133)1.90717628
115Abnormal enzyme/coenzyme activity (HP:0012379)1.88364147
116Exercise-induced muscle cramps (HP:0003710)1.87500824
117Hypophosphatemic rickets (HP:0004912)1.83670715
118Poikilocytosis (HP:0004447)1.81921779
119Glycosuria (HP:0003076)1.79722140
120Abnormality of urine glucose concentration (HP:0011016)1.79722140
121Elevated hepatic transaminases (HP:0002910)1.78807422
122Renal cortical cysts (HP:0000803)1.77507834
123Reduced antithrombin III activity (HP:0001976)1.73567243
124Abnormal atrioventricular conduction (HP:0005150)1.73296646
125Abnormal biliary tract physiology (HP:0012439)1.70872281
126Bile duct proliferation (HP:0001408)1.70872281
127Osteomalacia (HP:0002749)1.70203728
128Retinal atrophy (HP:0001105)1.66921427
129Purpura (HP:0000979)1.62458372
130Hyperphosphaturia (HP:0003109)1.61680368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18748329
2SIK14.74651065
3OBSCN4.32657990
4FGFR44.31550263
5ERN14.20616099
6PHKG13.46012390
7PHKG23.46012390
8INSRR2.81279080
9ERBB42.74326293
10TAOK32.45145606
11NTRK32.42228181
12TRIB32.32527548
13MST1R2.23262744
14MAP2K42.17596857
15PKN22.10838779
16MARK12.03206588
17MAPK111.83185031
18PIK3CA1.72860763
19LATS11.59383061
20FLT31.52444654
21PTK61.50680668
22DAPK21.46676978
23FGFR21.45873756
24PIK3CG1.43968546
25MAPKAPK31.39874844
26TYK21.38912066
27FRK1.35632296
28ABL21.32971377
29PINK11.32551425
30CAMK11.30378104
31MAP3K71.23140491
32NEK61.22385141
33PRKAA21.20584851
34GRK61.18252572
35STK38L1.18064896
36JAK21.15202234
37NEK91.13667740
38ERBB21.10055808
39EPHA41.07839456
40PAK61.07727005
41CAMK1D1.03008946
42NTRK21.02518145
43PRKG10.96124974
44KDR0.96007955
45MYLK0.94920042
46RIPK10.94132098
47PRKCZ0.93193022
48EPHB10.92898487
49SGK30.92095925
50JAK10.91018508
51PRKACA0.90999416
52WNK30.88633551
53MAPK40.86014247
54SGK10.85406993
55TTN0.84303235
56MAP2K30.84226682
57MET0.83838375
58MAPK120.82338074
59DYRK1B0.80656062
60TBK10.79983536
61PRKAA10.78693683
62PRKACG0.78501420
63CAMK2B0.78454485
64SGK20.78193143
65CAMKK20.77138932
66MAPK130.76892763
67PDK30.76609866
68PDK40.76609866
69GSK3A0.74509230
70SGK4940.73805698
71SGK2230.73805698
72CDK60.73604854
73RPS6KA30.73378887
74MAP3K100.73001363
75WNK40.72267116
76TIE10.72220498
77CAMK2A0.71874795
78NLK0.68739977
79MAP3K30.68735639
80MAP4K20.67980126
81MAPK150.67868310
82EPHA30.67729099
83FGFR30.67681771
84MAP2K60.67483441
85CAMK2G0.65964794
86MAP3K140.64829271
87CAMKK10.62702065
88MAP3K110.61567196
89CAMK2D0.60550975
90CDK50.59720826
91ADRBK20.59260130
92PDPK10.58443672
93OXSR10.58024765
94PTK20.57670516
95PRKCE0.56893577
96FER0.56741068
97CSK0.55136084
98MUSK0.54861627
99TNK20.54450913
100GRK50.54294968
101CAMK1G0.53838467
102BMPR1B0.53562955
103NEK10.53438110
104AKT20.53382643
105IRAK30.52994275
106PRKACB0.52931006
107LMTK20.52787526
108TRPM70.51318409
109ICK0.49981971
110MAPK70.49492749
111MAP2K10.49090528
112TGFBR20.47697301
113DYRK1A0.47136622
114CASK0.46280645
115MAPKAPK50.45911118
116TAOK20.45554313
117IGF1R0.45403370
118CSNK1A10.44004350
119CSNK1G10.43515685
120PRKCQ0.43033100
121PRKCG0.42835735
122CSF1R0.42192134
123RET0.41497521
124ROCK10.38952859
125BMX0.37850247
126PDK10.36644825
127IKBKE0.35794694
128PRKD30.35769478
129STK380.35661333
130MAP3K60.34142082
131GRK10.33587752
132PAK30.33235226
133MTOR0.32202117
134MAP3K130.31955207
135MAP3K50.31799078
136CAMK40.29668125
137PDK20.29577292
138EGFR0.29272267
139PKN10.28204136
140PDGFRA0.27860080
141PRKCA0.27706982
142CSNK1G20.26780516

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29019149
2Nitrogen metabolism_Homo sapiens_hsa009103.81449858
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32215136
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26541367
5Arginine biosynthesis_Homo sapiens_hsa002203.04855453
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68340837
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67926575
8Tryptophan metabolism_Homo sapiens_hsa003802.67027488
9Complement and coagulation cascades_Homo sapiens_hsa046102.55310031
10Fatty acid degradation_Homo sapiens_hsa000712.54869372
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53421393
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47830449
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28197638
14Butanoate metabolism_Homo sapiens_hsa006502.24094802
15Peroxisome_Homo sapiens_hsa041462.10756490
16Propanoate metabolism_Homo sapiens_hsa006402.08473162
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07209398
18PPAR signaling pathway_Homo sapiens_hsa033201.93404034
19Fatty acid metabolism_Homo sapiens_hsa012121.90870872
20Chemical carcinogenesis_Homo sapiens_hsa052041.88144560
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86625051
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.84712004
23Histidine metabolism_Homo sapiens_hsa003401.81659518
24Caffeine metabolism_Homo sapiens_hsa002321.76940461
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74774961
26beta-Alanine metabolism_Homo sapiens_hsa004101.72630705
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71310961
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68022261
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.66283909
30Retinol metabolism_Homo sapiens_hsa008301.61583105
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58659328
32Staphylococcus aureus infection_Homo sapiens_hsa051501.58268276
33Bile secretion_Homo sapiens_hsa049761.54619732
34Selenocompound metabolism_Homo sapiens_hsa004501.52825523
35Phenylalanine metabolism_Homo sapiens_hsa003601.50522168
36Pyruvate metabolism_Homo sapiens_hsa006201.44849046
37Sulfur metabolism_Homo sapiens_hsa009201.42760235
38Tyrosine metabolism_Homo sapiens_hsa003501.36045691
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35500511
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.30022799
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29996157
42Fatty acid elongation_Homo sapiens_hsa000621.27832988
43Biosynthesis of amino acids_Homo sapiens_hsa012301.25510774
44Carbon metabolism_Homo sapiens_hsa012001.20404643
45Steroid biosynthesis_Homo sapiens_hsa001001.19752250
46Folate biosynthesis_Homo sapiens_hsa007901.16709449
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14934683
48Fat digestion and absorption_Homo sapiens_hsa049751.14174235
49ABC transporters_Homo sapiens_hsa020101.13861546
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.11331057
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08629509
52Arginine and proline metabolism_Homo sapiens_hsa003300.99194177
53Sulfur relay system_Homo sapiens_hsa041220.94606195
54Vitamin digestion and absorption_Homo sapiens_hsa049770.93980830
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.90992286
56Vitamin B6 metabolism_Homo sapiens_hsa007500.89536775
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87798814
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82963964
59Lysine degradation_Homo sapiens_hsa003100.82169873
60Glycerolipid metabolism_Homo sapiens_hsa005610.76718502
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75473753
62Fatty acid biosynthesis_Homo sapiens_hsa000610.74467169
63Glutathione metabolism_Homo sapiens_hsa004800.70908517
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67239256
65Pentose phosphate pathway_Homo sapiens_hsa000300.60064666
66Metabolic pathways_Homo sapiens_hsa011000.46414974
67Fructose and mannose metabolism_Homo sapiens_hsa000510.33019420
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31520086
69Prion diseases_Homo sapiens_hsa050200.29756696
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28614795
71Galactose metabolism_Homo sapiens_hsa000520.28074680
72* One carbon pool by folate_Homo sapiens_hsa006700.27952470
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.27085004
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25308500
75Insulin resistance_Homo sapiens_hsa049310.25108127
76Circadian rhythm_Homo sapiens_hsa047100.18847087
77Linoleic acid metabolism_Homo sapiens_hsa005910.17381896
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17246904
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.17172921
80Glucagon signaling pathway_Homo sapiens_hsa049220.11639847
81AMPK signaling pathway_Homo sapiens_hsa041520.06545119
82GABAergic synapse_Homo sapiens_hsa047270.06422566
83Serotonergic synapse_Homo sapiens_hsa047260.05953847
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.05574608
85Pertussis_Homo sapiens_hsa051330.03915406
86Cardiac muscle contraction_Homo sapiens_hsa042600.02311938
87Insulin secretion_Homo sapiens_hsa049110.01802628
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.00329976
89Renin secretion_Homo sapiens_hsa049240.00220531
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2384886
91Bladder cancer_Homo sapiens_hsa05219-0.2328177
92Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2220481
93Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2196232
94Regulation of autophagy_Homo sapiens_hsa04140-0.1771882
95Hepatitis C_Homo sapiens_hsa05160-0.1753339
96Protein digestion and absorption_Homo sapiens_hsa04974-0.1750198
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1733233
98African trypanosomiasis_Homo sapiens_hsa05143-0.1721918
99Mineral absorption_Homo sapiens_hsa04978-0.1642620
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1480666
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1367597
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1295035
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1222743
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1082415
105Renin-angiotensin system_Homo sapiens_hsa04614-0.1041279
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0936455
107Insulin signaling pathway_Homo sapiens_hsa04910-0.0741452
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0740127
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0648872
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0549277
111Pancreatic secretion_Homo sapiens_hsa04972-0.0538356
112Ether lipid metabolism_Homo sapiens_hsa00565-0.0494420
113Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0425515
114Amphetamine addiction_Homo sapiens_hsa05031-0.0370210
115Glutamatergic synapse_Homo sapiens_hsa04724-0.0188171
116Nicotine addiction_Homo sapiens_hsa05033-0.0052857

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