ALDH1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)6.86378516
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.17565975
3COPI coating of Golgi vesicle (GO:0048205)6.07883084
4Golgi transport vesicle coating (GO:0048200)6.07883084
5collagen fibril organization (GO:0030199)5.87006626
6protein retention in ER lumen (GO:0006621)5.71957894
7peptidyl-proline hydroxylation (GO:0019511)5.30693437
8chondrocyte development (GO:0002063)5.05105310
9ER overload response (GO:0006983)5.03218220
10protein heterotrimerization (GO:0070208)4.76356716
11extracellular fibril organization (GO:0043206)4.72066624
12hemidesmosome assembly (GO:0031581)4.65635929
13chondrocyte proliferation (GO:0035988)4.64655880
14cell migration involved in heart development (GO:0060973)4.64636008
15intestinal cholesterol absorption (GO:0030299)4.63518966
16protein hydroxylation (GO:0018126)4.45487667
17type B pancreatic cell proliferation (GO:0044342)4.40109526
18bone trabecula formation (GO:0060346)4.28382029
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.26361880
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.23852582
21glomerular basement membrane development (GO:0032836)4.20896840
22COPII vesicle coating (GO:0048208)4.06482500
23digestion (GO:0007586)4.02436054
24positive regulation of nuclease activity (GO:0032075)4.01790177
25fibril organization (GO:0097435)3.94796659
26endoplasmic reticulum unfolded protein response (GO:0030968)3.93994648
27cellular response to unfolded protein (GO:0034620)3.85701401
28skin morphogenesis (GO:0043589)3.75111043
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.74728884
30insulin-like growth factor receptor signaling pathway (GO:0048009)3.74476876
31ER-nucleus signaling pathway (GO:0006984)3.73868615
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68835158
33multicellular organismal catabolic process (GO:0044243)3.68427490
34ganglion development (GO:0061548)3.66882485
35blood vessel maturation (GO:0001955)3.66263353
36regulation of nuclease activity (GO:0032069)3.62996079
37collagen catabolic process (GO:0030574)3.62656357
38substrate-dependent cell migration (GO:0006929)3.61542110
39cellular response to vitamin D (GO:0071305)3.60834015
40sequestering of extracellular ligand from receptor (GO:0035581)3.58030907
41cellular response to topologically incorrect protein (GO:0035967)3.57864937
42cell-substrate junction assembly (GO:0007044)3.57411520
43positive regulation of fibroblast migration (GO:0010763)3.53482428
44response to endoplasmic reticulum stress (GO:0034976)3.52730516
45collagen metabolic process (GO:0032963)3.51749816
46endodermal cell differentiation (GO:0035987)3.45506727
47multicellular organismal metabolic process (GO:0044236)3.45146848
48protein maturation by protein folding (GO:0022417)3.44744576
49cell migration involved in sprouting angiogenesis (GO:0002042)3.41376272
50smooth muscle tissue development (GO:0048745)3.40567091
51heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.38932169
52vascular endothelial growth factor signaling pathway (GO:0038084)3.38692219
53negative regulation of axon extension involved in axon guidance (GO:0048843)3.38154991
54substrate adhesion-dependent cell spreading (GO:0034446)3.35789439
55axon extension involved in axon guidance (GO:0048846)3.29101649
56neuron projection extension involved in neuron projection guidance (GO:1902284)3.29101649
57astrocyte differentiation (GO:0048708)3.28823616
58dermatan sulfate biosynthetic process (GO:0030208)3.27779011
59basement membrane organization (GO:0071711)3.26617351
60vesicle coating (GO:0006901)3.26041140
61regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25078619
62multicellular organismal macromolecule metabolic process (GO:0044259)3.25012156
63positive regulation of osteoblast proliferation (GO:0033690)3.23773388
64negative regulation of BMP signaling pathway (GO:0030514)3.18215323
65wound healing, spreading of epidermal cells (GO:0035313)3.15807676
66negative regulation of glycogen biosynthetic process (GO:0045719)3.14559818
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.13112424
68regulation of axon extension involved in axon guidance (GO:0048841)3.12967297
69keratan sulfate catabolic process (GO:0042340)3.12904425
70type B pancreatic cell development (GO:0003323)3.12769067
71tooth mineralization (GO:0034505)3.12190734
72cerebellar Purkinje cell layer development (GO:0021680)3.11487462
73metanephric mesenchyme development (GO:0072075)3.11252796
74positive regulation of blood vessel endothelial cell migration (GO:0043536)3.10531333
75face morphogenesis (GO:0060325)3.09407255
76retina vasculature morphogenesis in camera-type eye (GO:0061299)3.07642163
77regulation of extracellular matrix disassembly (GO:0010715)3.06203830
78cellular response to amino acid stimulus (GO:0071230)3.05112723
79negative regulation of smooth muscle cell migration (GO:0014912)3.04598388
80endocardial cushion development (GO:0003197)3.02177630
81adhesion of symbiont to host cell (GO:0044650)3.00657967
82virion attachment to host cell (GO:0019062)3.00657967
83dermatan sulfate metabolic process (GO:0030205)2.99962703
84response to redox state (GO:0051775)2.99948598
85response to unfolded protein (GO:0006986)2.98134099
86cellular response to vitamin (GO:0071295)2.97268131
87embryonic cranial skeleton morphogenesis (GO:0048701)2.96376294
88regulation of integrin-mediated signaling pathway (GO:2001044)2.95865046
89mesenchymal-epithelial cell signaling (GO:0060638)2.93202582
90extracellular matrix disassembly (GO:0022617)2.93032474
91pericardium development (GO:0060039)2.91296310
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85067242
93positive regulation of endothelial cell apoptotic process (GO:2000353)2.82459762
94protein localization to cell surface (GO:0034394)2.80803670
95kidney mesenchyme development (GO:0072074)2.80192769
964-hydroxyproline metabolic process (GO:0019471)2.78643066
97regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78467385
98response to topologically incorrect protein (GO:0035966)2.78331891
99stress fiber assembly (GO:0043149)2.77074571
100regulation of plasminogen activation (GO:0010755)2.76639577
101negative regulation of axon guidance (GO:1902668)2.76261964
102regulation of axon guidance (GO:1902667)2.75882126
103muscle cell migration (GO:0014812)2.75280314
104limb bud formation (GO:0060174)2.75052047
105regulation of osteoblast proliferation (GO:0033688)2.74003832
106sprouting angiogenesis (GO:0002040)2.73257464
107endocrine pancreas development (GO:0031018)2.72411626
108cochlea morphogenesis (GO:0090103)2.71299423
109inner ear receptor cell development (GO:0060119)2.70259028
110endothelial cell morphogenesis (GO:0001886)2.69795562
111negative regulation of stem cell proliferation (GO:2000647)2.69532242
112intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.69345413
113signal peptide processing (GO:0006465)2.68605252
114negative regulation of fatty acid transport (GO:2000192)2.68560162
115heparan sulfate proteoglycan metabolic process (GO:0030201)2.67539086
116negative regulation of glycogen metabolic process (GO:0070874)2.67147345
117negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.65721309
118establishment of tissue polarity (GO:0007164)2.64282714
119establishment of planar polarity (GO:0001736)2.64282714
120regulation of chondrocyte differentiation (GO:0032330)2.62842061
121positive regulation of mesenchymal cell proliferation (GO:0002053)2.61913366
122protein N-linked glycosylation via asparagine (GO:0018279)2.60109029
123glycolipid catabolic process (GO:0019377)2.59275617
124peptidyl-asparagine modification (GO:0018196)2.58295182
125cell adhesion mediated by integrin (GO:0033627)2.58164762
126positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57520321
127embryonic skeletal joint morphogenesis (GO:0060272)2.55105366
128negative regulation of osteoblast proliferation (GO:0033689)2.55100965
129glandular epithelial cell development (GO:0002068)2.54192194
130negative regulation of chondrocyte differentiation (GO:0032331)2.52857200
131extracellular matrix assembly (GO:0085029)2.52679744
132membrane lipid catabolic process (GO:0046466)2.51765243
133regulation of phospholipase A2 activity (GO:0032429)2.51201820
134plasma membrane repair (GO:0001778)2.51145095
135dendrite morphogenesis (GO:0048813)2.49450227
136polarized epithelial cell differentiation (GO:0030859)2.45242606
137extracellular negative regulation of signal transduction (GO:1900116)2.45018846
138extracellular regulation of signal transduction (GO:1900115)2.45018846
139regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44222461
140myoblast fusion (GO:0007520)2.44093670
141chondroitin sulfate biosynthetic process (GO:0030206)2.43586867
142negative chemotaxis (GO:0050919)2.43353884
143response to follicle-stimulating hormone (GO:0032354)2.42929442
144extracellular matrix organization (GO:0030198)2.40386039
145extracellular structure organization (GO:0043062)2.38987895
146protein N-linked glycosylation (GO:0006487)2.38127324
147chondroitin sulfate catabolic process (GO:0030207)2.37842898
148regulation of chemokine-mediated signaling pathway (GO:0070099)2.37422660
149craniofacial suture morphogenesis (GO:0097094)2.37329509
150ceramide catabolic process (GO:0046514)2.37234545
151ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.36779139
152endochondral ossification (GO:0001958)2.34331429
153replacement ossification (GO:0036075)2.34331429
154positive regulation of bone mineralization (GO:0030501)2.33970044
155Golgi organization (GO:0007030)2.33697791
156cartilage development (GO:0051216)2.33114540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.61964584
2GBX2_23144817_ChIP-Seq_PC3_Human2.85159135
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78853537
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68160045
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.66854512
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39140875
7EZH2_22144423_ChIP-Seq_EOC_Human2.21015436
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19686584
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15427176
10CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04136887
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03264188
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01417162
13NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.94673414
14NRF2_20460467_ChIP-Seq_MEFs_Mouse1.94673414
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.92401650
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85872784
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.85395967
18TP53_18474530_ChIP-ChIP_U2OS_Human1.82530071
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.81989894
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79584419
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78488398
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78293588
23CJUN_26792858_Chip-Seq_BT549_Human1.78131589
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77922063
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77349187
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75431196
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.74950054
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.74740733
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71408048
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.70816718
31AR_21572438_ChIP-Seq_LNCaP_Human1.69888765
32CLOCK_20551151_ChIP-Seq_293T_Human1.65526003
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63556337
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62515346
35BRD4_25478319_ChIP-Seq_HGPS_Human1.61365494
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60834111
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60819475
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59996121
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59996121
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59285196
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58212360
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57806922
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56982902
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55411328
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54358219
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54358219
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53262983
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52442367
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48396450
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45831893
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45518257
52SMAD4_21799915_ChIP-Seq_A2780_Human1.43921793
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.43025551
54* STAT3_23295773_ChIP-Seq_U87_Human1.40083692
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37969914
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36300405
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.36133095
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36018514
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35868080
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34775143
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34153756
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33971197
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33894752
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33122658
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31754140
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30752427
67AHR_22903824_ChIP-Seq_MCF-7_Human1.29041130
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.28932874
69IGF1R_20145208_ChIP-Seq_DFB_Human1.28116371
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27460615
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.27206234
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26773843
73ZNF274_21170338_ChIP-Seq_K562_Hela1.25975759
74DROSHA_22980978_ChIP-Seq_HELA_Human1.25649734
75ER_23166858_ChIP-Seq_MCF-7_Human1.24172783
76TP53_22127205_ChIP-Seq_IMR90_Human1.23787295
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23640140
78P300_19829295_ChIP-Seq_ESCs_Human1.22537408
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22151860
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21956284
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.21703534
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21628535
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20447936
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20096078
85SA1_22415368_ChIP-Seq_MEFs_Mouse1.19692651
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19224491
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.19014843
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.18769879
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.18406352
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.18094175
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17911796
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17638895
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17523609
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17390176
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17390044
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16958142
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16868965
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.15227851
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14094125
100TP53_16413492_ChIP-PET_HCT116_Human1.13436190
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.13229617
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.12724446
103SOX2_20726797_ChIP-Seq_SW620_Human1.12445033
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11483280
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10746591
106* TCF4_23295773_ChIP-Seq_U87_Human1.10517531
107TP63_23658742_ChIP-Seq_EP156T_Human1.08923106
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07207220
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06368821
110SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06015572
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.05549933
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04768262
113* AR_19668381_ChIP-Seq_PC3_Human1.04515355
114RUNX2_22187159_ChIP-Seq_PCA_Human1.04089593
115FUS_26573619_Chip-Seq_HEK293_Human1.03395430
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02954221
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02705597
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02354776
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01835211
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01497077
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.00682269
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00645077
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00347128
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99154123
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98736165
126* EZH2_27294783_Chip-Seq_NPCs_Mouse0.98439029
127AR_25329375_ChIP-Seq_VCAP_Human0.97869924
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.96913276
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96768731
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.96294031
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96251351
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.95147947
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.95147947
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95140898
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94822977
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93279294
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91724274
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91556559
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88406341
140JUN_21703547_ChIP-Seq_K562_Human0.85731934
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85700036
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85022315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.84209051
2MP0005503_abnormal_tendon_morphology4.96972974
3MP0005275_abnormal_skin_tensile3.64627876
4MP0005257_abnormal_intraocular_pressure2.81076998
5MP0002877_abnormal_melanocyte_morpholog2.75056238
6MP0009780_abnormal_chondrocyte_physiolo2.72409561
7MP0005220_abnormal_exocrine_pancreas2.71422188
8MP0005171_absent_coat_pigmentation2.49690767
9MP0001299_abnormal_eye_distance/2.38810115
10MP0002896_abnormal_bone_mineralization2.38747968
11MP0003279_aneurysm2.35070461
12MP0003283_abnormal_digestive_organ2.29779263
13MP0004134_abnormal_chest_morphology2.22210030
14MP0009384_cardiac_valve_regurgitation2.22147982
15MP0003705_abnormal_hypodermis_morpholog2.17509733
16MP0005508_abnormal_skeleton_morphology2.17366405
17MP0009250_abnormal_appendicular_skeleto2.12804239
18MP0005623_abnormal_meninges_morphology2.01185228
19MP0000569_abnormal_digit_pigmentation1.98322815
20MP0003941_abnormal_skin_development1.96968536
21MP0001958_emphysema1.94943533
22MP0002108_abnormal_muscle_morphology1.86358809
23MP0006054_spinal_hemorrhage1.73043285
24MP0005023_abnormal_wound_healing1.65347779
25MP0001542_abnormal_bone_strength1.63602868
26MP0000767_abnormal_smooth_muscle1.63168142
27MP0002060_abnormal_skin_morphology1.54659271
28MP0003045_fibrosis1.52126373
29MP0004272_abnormal_basement_membrane1.50902160
30MP0003868_abnormal_feces_composition1.45762467
31MP0010352_gastrointestinal_tract_polyps1.44441258
32MP0000163_abnormal_cartilage_morphology1.43830493
33MP0004858_abnormal_nervous_system1.42662864
34MP0002115_abnormal_skeleton_extremities1.40154333
35MP0001666_abnormal_nutrient_absorption1.39103723
36MP0000013_abnormal_adipose_tissue1.38703745
37MP0001944_abnormal_pancreas_morphology1.36678496
38MP0002693_abnormal_pancreas_physiology1.34173611
39MP0001188_hyperpigmentation1.33911040
40MP0010386_abnormal_urinary_bladder1.33226940
41MP0003091_abnormal_cell_migration1.32158481
42MP0000733_abnormal_muscle_development1.31707341
43MP0010368_abnormal_lymphatic_system1.27819504
44MP0003122_maternal_imprinting1.25798302
45MP0000428_abnormal_craniofacial_morphol1.25430506
46MP0005083_abnormal_biliary_tract1.25044520
47MP0003755_abnormal_palate_morphology1.24541761
48MP0010030_abnormal_orbit_morphology1.23692904
49MP0002933_joint_inflammation1.19166125
50MP0003385_abnormal_body_wall1.19042040
51MP0004233_abnormal_muscle_weight1.19034990
52MP0002116_abnormal_craniofacial_bone1.17982531
53MP0002113_abnormal_skeleton_development1.17373634
54MP0001346_abnormal_lacrimal_gland1.15426111
55MP0005390_skeleton_phenotype1.12848838
56MP0002295_abnormal_pulmonary_circulatio1.12456186
57MP0002089_abnormal_postnatal_growth/wei1.11696628
58MP0003937_abnormal_limbs/digits/tail_de1.07657915
59MP0005084_abnormal_gallbladder_morpholo1.05878823
60MP0005248_abnormal_Harderian_gland1.05179552
61MP0002168_other_aberrant_phenotype1.04295680
62MP0002109_abnormal_limb_morphology1.03965387
63MP0003795_abnormal_bone_structure1.03568631
64MP0002233_abnormal_nose_morphology1.03547940
65MP0000003_abnormal_adipose_tissue1.02429925
66MP0002998_abnormal_bone_remodeling1.02006095
67MP0002234_abnormal_pharynx_morphology1.00686100
68MP0000462_abnormal_digestive_system0.99192087
69MP0003566_abnormal_cell_adhesion0.98312307
70MP0000049_abnormal_middle_ear0.97861688
71MP0002932_abnormal_joint_morphology0.97854769
72MP0009053_abnormal_anal_canal0.97630614
73MP0000432_abnormal_head_morphology0.96081950
74MP0003942_abnormal_urinary_system0.95819600
75MP0003959_abnormal_lean_body0.93361153
76MP0002282_abnormal_trachea_morphology0.92411647
77MP0000538_abnormal_urinary_bladder0.91973017
78MP0000566_synostosis0.91862883
79MP0000749_muscle_degeneration0.91554104
80MP0000759_abnormal_skeletal_muscle0.90169244
81MP0005595_abnormal_vascular_smooth0.89590147
82MP0000534_abnormal_ureter_morphology0.89077187
83MP0000516_abnormal_urinary_system0.89062850
84MP0005367_renal/urinary_system_phenotyp0.89062850
85MP0002177_abnormal_outer_ear0.88548413
86MP0001243_abnormal_dermal_layer0.88361978
87MP0002938_white_spotting0.87930893
88MP0000778_abnormal_nervous_system0.84700493
89MP0000751_myopathy0.84187185
90MP0003935_abnormal_craniofacial_develop0.83782088
91MP0000762_abnormal_tongue_morphology0.82636367
92MP0001879_abnormal_lymphatic_vessel0.79381555
93MP0002114_abnormal_axial_skeleton0.75491036
94MP0004084_abnormal_cardiac_muscle0.75170487
95MP0001348_abnormal_lacrimal_gland0.74739112
96MP0004145_abnormal_muscle_electrophysio0.73789540
97MP0001177_atelectasis0.73507023
98MP0000372_irregular_coat_pigmentation0.73248604
99MP0000631_abnormal_neuroendocrine_gland0.72551146
100MP0001661_extended_life_span0.70781321
101MP0003115_abnormal_respiratory_system0.70204260
102MP0002909_abnormal_adrenal_gland0.69329378
103MP0000750_abnormal_muscle_regeneration0.69259470
104MP0001270_distended_abdomen0.68923705
105MP0002111_abnormal_tail_morphology0.67803456
106MP0002128_abnormal_blood_circulation0.67771645
107MP0008004_abnormal_stomach_pH0.67711752
108MP0005076_abnormal_cell_differentiation0.67036094
109MP0000613_abnormal_salivary_gland0.66605108
110MP0005197_abnormal_uvea_morphology0.66178351
111MP0005164_abnormal_response_to0.65616513
112MP0002254_reproductive_system_inflammat0.64885735
113MP0002133_abnormal_respiratory_system0.64847091
114MP0005388_respiratory_system_phenotype0.64847091
115MP0003300_gastrointestinal_ulcer0.64753991
116MP0000678_abnormal_parathyroid_gland0.63209095
117MP0009703_decreased_birth_body0.62871902
118MP0000537_abnormal_urethra_morphology0.61909156
119MP0000467_abnormal_esophagus_morphology0.61151711
120MP0001186_pigmentation_phenotype0.59904745
121MP0010771_integument_phenotype0.58805264
122MP0001614_abnormal_blood_vessel0.58725428
123MP0003950_abnormal_plasma_membrane0.58484450
124MP0002269_muscular_atrophy0.56430860
125MP0001175_abnormal_lung_morphology0.54101077
126MP0003448_altered_tumor_morphology0.53713003
127MP0005369_muscle_phenotype0.53183491
128MP0005409_darkened_coat_color0.47956480
129MP0002925_abnormal_cardiovascular_devel0.47571578
130MP0005193_abnormal_anterior_eye0.46971006
131MP0001915_intracranial_hemorrhage0.45491033
132MP0008775_abnormal_heart_ventricle0.43419696
133MP0005621_abnormal_cell_physiology0.42942069
134MP0001849_ear_inflammation0.42051425
135MP0000747_muscle_weakness0.40424359

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.60959767
2Protrusio acetabuli (HP:0003179)5.76600171
3Neonatal short-limb short stature (HP:0008921)4.18037539
4Cervical subluxation (HP:0003308)3.87396167
5Atrophic scars (HP:0001075)3.77464781
6Arterial tortuosity (HP:0005116)3.72219374
7Abnormality of dentin (HP:0010299)3.69770764
8Spondylolisthesis (HP:0003302)3.66587355
9Epiphyseal dysplasia (HP:0002656)3.64255536
10Hypoplastic ischia (HP:0003175)3.54426528
11Shallow orbits (HP:0000586)3.54218312
12Soft skin (HP:0000977)3.50268887
13Ankle contracture (HP:0006466)3.37445339
14Abnormality of the ischium (HP:0003174)3.25490222
15Aortic dissection (HP:0002647)3.21523109
16Wormian bones (HP:0002645)3.10190426
17Follicular hyperkeratosis (HP:0007502)3.05345584
18Peritonitis (HP:0002586)3.02073301
19Infantile muscular hypotonia (HP:0008947)2.91311998
20Fragile skin (HP:0001030)2.90407054
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.82720859
22Mildly elevated creatine phosphokinase (HP:0008180)2.82646659
23Bladder diverticulum (HP:0000015)2.82224754
24Genu recurvatum (HP:0002816)2.80713937
25Type 1 muscle fiber predominance (HP:0003803)2.80415632
26Mild short stature (HP:0003502)2.75234025
27Cupped ribs (HP:0000887)2.74851004
28Broad ribs (HP:0000885)2.68467481
29Osteoarthritis (HP:0002758)2.64706296
30Mitral regurgitation (HP:0001653)2.64455266
31Aortic valve stenosis (HP:0001650)2.64455218
32Small epiphyses (HP:0010585)2.63104672
33Redundant skin (HP:0001582)2.62327306
34Spinal cord compression (HP:0002176)2.57943912
35Bell-shaped thorax (HP:0001591)2.57189912
36Cerebral aneurysm (HP:0004944)2.56513481
37Dilatation of the ascending aorta (HP:0005111)2.55354197
38Hyperextensible skin (HP:0000974)2.54269704
39Nonimmune hydrops fetalis (HP:0001790)2.48715140
40Blue sclerae (HP:0000592)2.48252686
41Biconcave vertebral bodies (HP:0004586)2.48213806
42Round ear (HP:0100830)2.45861489
43Spinal rigidity (HP:0003306)2.44965930
44Hypoplasia of the odontoid process (HP:0003311)2.44963122
45Wrist flexion contracture (HP:0001239)2.41209704
46Vitreoretinal degeneration (HP:0000655)2.41089864
47Exostoses (HP:0100777)2.38799941
48Mesomelia (HP:0003027)2.36878638
49Flat cornea (HP:0007720)2.36210246
50Mitral valve prolapse (HP:0001634)2.34739737
51Coronal craniosynostosis (HP:0004440)2.31767463
52Abnormality of the odontoid process (HP:0003310)2.30223291
53Broad metatarsal (HP:0001783)2.30190503
54Congenital glaucoma (HP:0001087)2.26524641
55Aneurysm (HP:0002617)2.25902097
56Abnormality of the acetabulum (HP:0003170)2.25442483
57Platyspondyly (HP:0000926)2.23790134
58Flat capital femoral epiphysis (HP:0003370)2.22541262
59Vertebral compression fractures (HP:0002953)2.21510530
60Joint stiffness (HP:0001387)2.20525046
61Tibial bowing (HP:0002982)2.20302113
62Disproportionate short-trunk short stature (HP:0003521)2.19258178
63Thoracolumbar scoliosis (HP:0002944)2.19195686
64Asymmetry of the thorax (HP:0001555)2.18707638
65Overgrowth (HP:0001548)2.17866422
66Osteolytic defects of the hand bones (HP:0009699)2.10579960
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.10579960
68Thin ribs (HP:0000883)2.10381848
69Broad long bones (HP:0005622)2.09383622
70Bowel diverticulosis (HP:0005222)2.09049354
71Inguinal hernia (HP:0000023)2.07372607
72Flattened epiphyses (HP:0003071)2.06680695
73Deformed tarsal bones (HP:0008119)2.06446664
74Abnormality of skeletal muscle fiber size (HP:0012084)2.03504048
75Abnormal foot bone ossification (HP:0010675)2.03376077
76Aortic aneurysm (HP:0004942)2.03088652
77Delayed closure of the anterior fontanelle (HP:0001476)2.02164839
78Calcaneovalgus deformity (HP:0001848)2.01003448
79Mitral stenosis (HP:0001718)2.00762389
80Protruding ear (HP:0000411)2.00479288
81Aplasia involving bones of the upper limbs (HP:0009823)2.00145589
82Aplasia of the phalanges of the hand (HP:0009802)2.00145589
83Aplasia involving bones of the extremities (HP:0009825)2.00145589
84Slender build (HP:0001533)1.99934603
85Irregular epiphyses (HP:0010582)1.99067670
86Natal tooth (HP:0000695)1.98609909
87Decreased skull ossification (HP:0004331)1.96587115
88Hypoplasia of the iris (HP:0007676)1.95813437
89Cardiovascular calcification (HP:0011915)1.95458152
90Breech presentation (HP:0001623)1.95053007
91Abnormal tarsal ossification (HP:0008369)1.94826608
92Ovoid vertebral bodies (HP:0003300)1.93586913
93Renal duplication (HP:0000075)1.91878903
94Ectopia lentis (HP:0001083)1.91098355
95Buphthalmos (HP:0000557)1.90627078
96Joint laxity (HP:0001388)1.90218107
97Delayed gross motor development (HP:0002194)1.89768668
98Venous insufficiency (HP:0005293)1.89350583
99Pectus carinatum (HP:0000768)1.87994106
100Femoral bowing (HP:0002980)1.86359356
101Increased corneal curvature (HP:0100692)1.85047163
102Keratoconus (HP:0000563)1.85047163
103Ulnar bowing (HP:0003031)1.84039532
104Syringomyelia (HP:0003396)1.83704266
105Spinal cord lesions (HP:0100561)1.83704266
106Elbow flexion contracture (HP:0002987)1.82540352
107Fibular aplasia (HP:0002990)1.82086818
108Morphological abnormality of the middle ear (HP:0008609)1.80908430
109Abnormality of skull ossification (HP:0002703)1.79817400
110Thin bony cortex (HP:0002753)1.79637502
111Flared iliac wings (HP:0002869)1.78729583
112Abnormal delivery (HP:0001787)1.78143101
113Venous abnormality (HP:0002624)1.78006343
114Abnormality of the calcaneus (HP:0008364)1.77209861
115Flat acetabular roof (HP:0003180)1.75663348
116Vascular tortuosity (HP:0004948)1.75098847
117Decreased subcutaneous fat (HP:0001002)1.74740157
118Cortical dysplasia (HP:0002539)1.73674621
119Beaking of vertebral bodies (HP:0004568)1.73618642
120Striae distensae (HP:0001065)1.73167528
121Delayed cranial suture closure (HP:0000270)1.72950757
122Hypoventilation (HP:0002791)1.72398174
123Generalized amyotrophy (HP:0003700)1.72258082
124Increased variability in muscle fiber diameter (HP:0003557)1.72155184
125Deviation of the hallux (HP:0010051)1.72105709
126Abnormal vertebral ossification (HP:0100569)1.71230005
127Aortic regurgitation (HP:0001659)1.70625834
128Thin skin (HP:0000963)1.70018156
129Camptodactyly of toe (HP:0001836)1.69888427
130Tracheomalacia (HP:0002779)1.69836684
131Pulmonic stenosis (HP:0001642)1.69782534
132Limited hip movement (HP:0008800)1.69510465
133Knee flexion contracture (HP:0006380)1.68457815
134Absent frontal sinuses (HP:0002688)1.67929521
135Broad phalanx (HP:0006009)1.67639670
136Hallux valgus (HP:0001822)1.66862695
137Disproportionate tall stature (HP:0001519)1.66852075
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66354201
139Premature skin wrinkling (HP:0100678)1.65463501
140Irregular vertebral endplates (HP:0003301)1.64728566
141Wide anterior fontanel (HP:0000260)1.64430257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.85146076
2MYLK4.20258771
3NEK93.85713009
4LATS13.41941977
5EPHA33.11176464
6PDGFRA2.87504543
7INSRR2.61455362
8FRK2.59297691
9ERBB32.38905337
10TAOK32.34573094
11NUAK12.11887709
12PIK3CG2.08552613
13PRKD31.97107582
14MARK11.96991084
15CASK1.95002042
16TRIB31.90122206
17ERN11.88016407
18TTN1.85525562
19LIMK11.78877672
20STK381.72364252
21TGFBR21.70636770
22SIK11.61401959
23EEF2K1.57761199
24PAK41.57596011
25PKN21.57074956
26CDC42BPA1.50235350
27PDGFRB1.48958909
28TRPM71.48143323
29PAK31.47665363
30PIK3CA1.46654554
31EIF2AK31.38392147
32MET1.36273536
33DYRK21.32220677
34PAK21.30092406
35KIT1.27381983
36SCYL21.27274838
37CAMKK21.27145634
38AKT31.25667890
39TESK11.21250534
40PLK21.18300419
41HIPK21.14653146
42MAPK131.14584362
43LATS21.09941603
44EIF2AK21.06190751
45STK31.04938060
46FER1.01955940
47ERBB41.00074180
48CDK120.96006708
49FGFR20.95509944
50PTK20.95438785
51CAMK1G0.94271117
52NTRK30.93455700
53PRPF4B0.91851564
54LMTK20.90567294
55ABL20.90119089
56FLT30.88585779
57MTOR0.88314461
58ROCK10.88311365
59PRKCE0.87751650
60UHMK10.87027333
61NEK60.86699685
62PASK0.86381066
63MOS0.84883533
64PTK2B0.83646477
65BMX0.82990764
66FGFR30.82255421
67EPHB20.82165958
68PIM20.80856673
69PRKCH0.80413118
70PRKG20.80357713
71CAMK1D0.80126328
72IRAK10.80109064
73DMPK0.77863140
74WNK10.77775776
75PTK60.77213250
76NTRK10.76288290
77PNCK0.75728921
78PAK60.75353903
79IRAK30.74676477
80TGFBR10.74567764
81ROCK20.74440634
82SGK2230.74011056
83SGK4940.74011056
84ICK0.72403236
85RET0.72227324
86DYRK1A0.72200568
87DYRK1B0.70669927
88FGFR10.69383089
89CLK10.67257664
90JAK10.66005904
91KSR20.64125778
92EPHB10.62261222
93BRD40.61108295
94YES10.61043268
95MST1R0.59837487
96PHKG20.59732634
97PHKG10.59732634
98MAP2K10.58632216
99PRKD20.58624879
100SGK20.57711445
101CDK80.56527333
102MAP3K60.56240286
103WNK40.56079279
104MUSK0.56012708
105DAPK30.54291801
106BMPR1B0.53614686
107STK240.52982996
108RPS6KA40.52841601
109PKN10.50826082
110INSR0.50529201
111IGF1R0.50078405
112RPS6KB10.49096870
113STK38L0.49008292
114BRSK20.48931956
115BCR0.48728777
116MAPK70.48274231
117PRKD10.47594356
118GRK70.47198175
119ADRBK20.46902172
120MELK0.46628277
121GSK3A0.45552659
122RPS6KA20.45091097
123CAMKK10.45015819
124MARK20.44381740
125MAPKAPK30.43271091
126GRK10.42603050
127ILK0.42203157
128MAP3K120.42050566
129RAF10.40795406
130ADRBK10.39530567
131KSR10.39206959
132RIPK10.38645153
133MAP3K20.38262493
134PRKAA10.37912645
135AKT10.37106148
136CSNK1A1L0.36089357
137EIF2AK10.34438254
138ABL10.33068638
139CAMK2G0.30526604
140MAPKAPK50.28692864
141NEK10.27649357
142PAK10.26535157
143ARAF0.26074285
144MAPK10.25508577
145NEK20.19704621

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049743.87219125
2Protein export_Homo sapiens_hsa030603.68740397
3Pancreatic secretion_Homo sapiens_hsa049723.06234521
4ECM-receptor interaction_Homo sapiens_hsa045122.82083891
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.81049200
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.62506959
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09768183
8Focal adhesion_Homo sapiens_hsa045101.85187423
9Steroid biosynthesis_Homo sapiens_hsa001001.61885063
10Insulin secretion_Homo sapiens_hsa049111.58084284
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57788137
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49935404
13N-Glycan biosynthesis_Homo sapiens_hsa005101.44564068
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42510809
15Selenocompound metabolism_Homo sapiens_hsa004501.35490548
16Prostate cancer_Homo sapiens_hsa052151.34193726
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33448886
18Vibrio cholerae infection_Homo sapiens_hsa051101.32121667
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30906379
20Dilated cardiomyopathy_Homo sapiens_hsa054141.28799586
21Melanoma_Homo sapiens_hsa052181.27341073
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.25777853
23Bladder cancer_Homo sapiens_hsa052191.19269429
24Vitamin B6 metabolism_Homo sapiens_hsa007501.18913268
25Adherens junction_Homo sapiens_hsa045201.16523165
26Endometrial cancer_Homo sapiens_hsa052131.15516481
27Proteoglycans in cancer_Homo sapiens_hsa052051.12801906
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11919681
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10069768
30Fat digestion and absorption_Homo sapiens_hsa049751.09492354
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.09017992
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.06164660
33Axon guidance_Homo sapiens_hsa043601.04606309
34MicroRNAs in cancer_Homo sapiens_hsa052061.02170337
35Glioma_Homo sapiens_hsa052141.00786113
36Amoebiasis_Homo sapiens_hsa051460.98580813
37Cocaine addiction_Homo sapiens_hsa050300.97791718
38Sulfur metabolism_Homo sapiens_hsa009200.97106579
39Pancreatic cancer_Homo sapiens_hsa052120.96163102
40p53 signaling pathway_Homo sapiens_hsa041150.95974429
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94945211
42Dorso-ventral axis formation_Homo sapiens_hsa043200.93801731
43Chronic myeloid leukemia_Homo sapiens_hsa052200.93750586
44Type I diabetes mellitus_Homo sapiens_hsa049400.93051039
45Type II diabetes mellitus_Homo sapiens_hsa049300.91879981
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89933232
47Sphingolipid metabolism_Homo sapiens_hsa006000.89363398
48Phagosome_Homo sapiens_hsa041450.88312611
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88251535
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86874895
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83844993
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83068093
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82069763
54mTOR signaling pathway_Homo sapiens_hsa041500.81344747
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.81098721
56Hippo signaling pathway_Homo sapiens_hsa043900.79049430
57Lysosome_Homo sapiens_hsa041420.77816365
58ErbB signaling pathway_Homo sapiens_hsa040120.77517080
59Cholinergic synapse_Homo sapiens_hsa047250.76244082
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75642588
61Renal cell carcinoma_Homo sapiens_hsa052110.75327648
62Basal cell carcinoma_Homo sapiens_hsa052170.75266405
63Viral myocarditis_Homo sapiens_hsa054160.73253293
64Small cell lung cancer_Homo sapiens_hsa052220.73119210
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73016090
66Wnt signaling pathway_Homo sapiens_hsa043100.71998354
67Hedgehog signaling pathway_Homo sapiens_hsa043400.70960644
68Malaria_Homo sapiens_hsa051440.70284587
69Colorectal cancer_Homo sapiens_hsa052100.68299104
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68079975
71Estrogen signaling pathway_Homo sapiens_hsa049150.66936836
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65177510
73Gap junction_Homo sapiens_hsa045400.63561086
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.63374142
75Lysine degradation_Homo sapiens_hsa003100.63309969
76Ovarian steroidogenesis_Homo sapiens_hsa049130.62377917
77Prion diseases_Homo sapiens_hsa050200.61431653
78FoxO signaling pathway_Homo sapiens_hsa040680.60958334
79TGF-beta signaling pathway_Homo sapiens_hsa043500.60399661
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59832040
81Ras signaling pathway_Homo sapiens_hsa040140.59796067
82Melanogenesis_Homo sapiens_hsa049160.59112638
83Long-term depression_Homo sapiens_hsa047300.58650724
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.56883767
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54552229
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53274150
87MAPK signaling pathway_Homo sapiens_hsa040100.52278137
88Serotonergic synapse_Homo sapiens_hsa047260.52196050
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52102234
90Thyroid cancer_Homo sapiens_hsa052160.51942583
91TNF signaling pathway_Homo sapiens_hsa046680.51866485
92Thyroid hormone synthesis_Homo sapiens_hsa049180.51480104
93Pathways in cancer_Homo sapiens_hsa052000.50859464
94Circadian rhythm_Homo sapiens_hsa047100.50821846
95Prolactin signaling pathway_Homo sapiens_hsa049170.50382424
96Renin-angiotensin system_Homo sapiens_hsa046140.49980239
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49462938
98Tight junction_Homo sapiens_hsa045300.48532821
99Calcium signaling pathway_Homo sapiens_hsa040200.48259972
100Hepatitis B_Homo sapiens_hsa051610.47419844
101Insulin resistance_Homo sapiens_hsa049310.46782042
102GnRH signaling pathway_Homo sapiens_hsa049120.46348340
103Endocytosis_Homo sapiens_hsa041440.46306048
104Shigellosis_Homo sapiens_hsa051310.45566552
105Rap1 signaling pathway_Homo sapiens_hsa040150.44122841
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44016852
107Dopaminergic synapse_Homo sapiens_hsa047280.43548753
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43295599
109Non-small cell lung cancer_Homo sapiens_hsa052230.42713313
110Circadian entrainment_Homo sapiens_hsa047130.42393256
111Insulin signaling pathway_Homo sapiens_hsa049100.42165378
112Platelet activation_Homo sapiens_hsa046110.41674766
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39916352
114AMPK signaling pathway_Homo sapiens_hsa041520.39469910
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38889363
116Oxytocin signaling pathway_Homo sapiens_hsa049210.38593613
117* One carbon pool by folate_Homo sapiens_hsa006700.37411341
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.35594494
119cAMP signaling pathway_Homo sapiens_hsa040240.34847149
120Other glycan degradation_Homo sapiens_hsa005110.34507550
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34250313
122Choline metabolism in cancer_Homo sapiens_hsa052310.33441755
123Glucagon signaling pathway_Homo sapiens_hsa049220.32007480

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »