ALDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.77581239
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.77581239
3L-phenylalanine metabolic process (GO:0006558)6.61115050
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61115050
5aromatic amino acid family catabolic process (GO:0009074)6.09783348
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82812504
7alpha-linolenic acid metabolic process (GO:0036109)5.65000829
8kynurenine metabolic process (GO:0070189)5.50489167
9tryptophan catabolic process (GO:0006569)5.50368076
10indole-containing compound catabolic process (GO:0042436)5.50368076
11indolalkylamine catabolic process (GO:0046218)5.50368076
12glyoxylate metabolic process (GO:0046487)5.48237704
13sulfur amino acid catabolic process (GO:0000098)5.39561552
14bile acid biosynthetic process (GO:0006699)5.38779593
15cysteine metabolic process (GO:0006534)5.26109517
16urea metabolic process (GO:0019627)5.21434396
17urea cycle (GO:0000050)5.21434396
18tryptophan metabolic process (GO:0006568)5.17499211
19complement activation, alternative pathway (GO:0006957)5.17445443
20exogenous drug catabolic process (GO:0042738)5.11379318
21negative regulation of fibrinolysis (GO:0051918)5.07684139
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.06013266
23high-density lipoprotein particle remodeling (GO:0034375)5.03153942
24protein carboxylation (GO:0018214)4.99894852
25peptidyl-glutamic acid carboxylation (GO:0017187)4.99894852
26regulation of protein activation cascade (GO:2000257)4.88732465
27lysine catabolic process (GO:0006554)4.87287367
28lysine metabolic process (GO:0006553)4.87287367
29nitrogen cycle metabolic process (GO:0071941)4.80859100
30serine family amino acid catabolic process (GO:0009071)4.78869383
31regulation of fibrinolysis (GO:0051917)4.74489358
32regulation of triglyceride catabolic process (GO:0010896)4.65398118
33amino-acid betaine metabolic process (GO:0006577)4.64881463
34regulation of complement activation (GO:0030449)4.61913774
35epoxygenase P450 pathway (GO:0019373)4.60780805
36bile acid metabolic process (GO:0008206)4.60372874
37homocysteine metabolic process (GO:0050667)4.59976454
38reverse cholesterol transport (GO:0043691)4.42113132
39aromatic amino acid family metabolic process (GO:0009072)4.41239706
40negative regulation of cholesterol transport (GO:0032375)4.33109060
41negative regulation of sterol transport (GO:0032372)4.33109060
42protein-lipid complex remodeling (GO:0034368)4.32678683
43macromolecular complex remodeling (GO:0034367)4.32678683
44plasma lipoprotein particle remodeling (GO:0034369)4.32678683
45regulation of cholesterol esterification (GO:0010872)4.31754940
46plasma lipoprotein particle clearance (GO:0034381)4.30513328
47alpha-amino acid catabolic process (GO:1901606)4.30438040
48tyrosine metabolic process (GO:0006570)4.21817783
49triglyceride homeostasis (GO:0070328)4.21647572
50acylglycerol homeostasis (GO:0055090)4.21647572
51phospholipid efflux (GO:0033700)4.15518848
52glycine metabolic process (GO:0006544)4.14586635
53cellular ketone body metabolic process (GO:0046950)4.11159083
54cellular amino acid catabolic process (GO:0009063)4.03678140
55serine family amino acid metabolic process (GO:0009069)4.01276928
56cellular modified amino acid catabolic process (GO:0042219)3.96912747
57* ethanol metabolic process (GO:0006067)3.95591335
58benzene-containing compound metabolic process (GO:0042537)3.91000430
59bile acid and bile salt transport (GO:0015721)3.89706815
60glutamate metabolic process (GO:0006536)3.87938468
61cellular glucuronidation (GO:0052695)3.87697536
62coenzyme catabolic process (GO:0009109)3.87259599
63imidazole-containing compound metabolic process (GO:0052803)3.87255697
64drug catabolic process (GO:0042737)3.83869946
65short-chain fatty acid metabolic process (GO:0046459)3.80605855
66indolalkylamine metabolic process (GO:0006586)3.80081189
672-oxoglutarate metabolic process (GO:0006103)3.79685726
68regulation of cholesterol homeostasis (GO:2000188)3.79641003
69serine family amino acid biosynthetic process (GO:0009070)3.77006551
70cholesterol efflux (GO:0033344)3.76336948
71acetyl-CoA metabolic process (GO:0006084)3.75594211
72fatty acid beta-oxidation (GO:0006635)3.74431342
73positive regulation of lipid catabolic process (GO:0050996)3.72899167
74valine metabolic process (GO:0006573)3.72848140
75omega-hydroxylase P450 pathway (GO:0097267)3.71687440
76fatty acid oxidation (GO:0019395)3.70530081
77plasma lipoprotein particle assembly (GO:0034377)3.69180060
78phospholipid homeostasis (GO:0055091)3.67991870
79dicarboxylic acid biosynthetic process (GO:0043650)3.67853139
80amine catabolic process (GO:0009310)3.67638180
81cellular biogenic amine catabolic process (GO:0042402)3.67638180
82carboxylic acid catabolic process (GO:0046395)3.65664424
83organic acid catabolic process (GO:0016054)3.65664424
84aldehyde catabolic process (GO:0046185)3.64306814
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.63379415
86carnitine metabolic process (GO:0009437)3.63355673
87lipid oxidation (GO:0034440)3.63212818
88drug metabolic process (GO:0017144)3.59509784
89arginine metabolic process (GO:0006525)3.58719466
90fibrinolysis (GO:0042730)3.58524409
91positive regulation of triglyceride lipase activity (GO:0061365)3.58137715
92positive regulation of lipoprotein lipase activity (GO:0051006)3.58137715
93monocarboxylic acid catabolic process (GO:0072329)3.56532826
94cholesterol homeostasis (GO:0042632)3.55242112
95ketone body metabolic process (GO:1902224)3.55041193
96complement activation (GO:0006956)3.54922453
97fatty acid catabolic process (GO:0009062)3.53185218
98complement activation, classical pathway (GO:0006958)3.51789576
99triglyceride catabolic process (GO:0019433)3.51069629
100low-density lipoprotein particle clearance (GO:0034383)3.50743535
101sterol homeostasis (GO:0055092)3.50348753
102negative regulation of lipase activity (GO:0060192)3.49807215
103low-density lipoprotein particle remodeling (GO:0034374)3.49412778
104aspartate family amino acid catabolic process (GO:0009068)3.48379652
105* ethanol oxidation (GO:0006069)3.46520458
106flavonoid metabolic process (GO:0009812)3.45613156
107urate metabolic process (GO:0046415)3.45354890
108acylglycerol catabolic process (GO:0046464)3.37775822
109neutral lipid catabolic process (GO:0046461)3.37775822
110regulation of sequestering of triglyceride (GO:0010889)3.22798920
111protein activation cascade (GO:0072376)3.20330866
112diacylglycerol metabolic process (GO:0046339)3.10387189
113fat-soluble vitamin biosynthetic process (GO:0042362)3.04782718
114NADH metabolic process (GO:0006734)3.01322494
115transcytosis (GO:0045056)2.99440457
116uronic acid metabolic process (GO:0006063)2.94180816
117glucuronate metabolic process (GO:0019585)2.94180816
118blood coagulation, intrinsic pathway (GO:0007597)2.87512375
119* primary alcohol metabolic process (GO:0034308)2.85634981
120acute-phase response (GO:0006953)2.77497549
121regulation of sterol transport (GO:0032371)2.75973733
122regulation of cholesterol transport (GO:0032374)2.75973733
123negative regulation of protein activation cascade (GO:2000258)2.75567238
124cGMP-mediated signaling (GO:0019934)2.74344899
125response to mercury ion (GO:0046689)2.72505459
126negative regulation of blood coagulation (GO:0030195)2.68587484
127negative regulation of hemostasis (GO:1900047)2.68587484
128positive regulation of cholesterol transport (GO:0032376)2.59915606
129positive regulation of sterol transport (GO:0032373)2.59915606
130glycerolipid catabolic process (GO:0046503)2.56892650
131positive regulation of cholesterol efflux (GO:0010875)2.56738809
132positive regulation of triglyceride metabolic process (GO:0090208)2.55603290
133regulation of triglyceride metabolic process (GO:0090207)2.54792427
134oxidative demethylation (GO:0070989)2.54220484
135negative regulation of complement activation (GO:0045916)2.53745279
136oxaloacetate metabolic process (GO:0006107)2.52902223
137phenylpropanoid metabolic process (GO:0009698)2.52863174
138fatty acid homeostasis (GO:0055089)2.51637388
139response to dietary excess (GO:0002021)2.50146330
140doxorubicin metabolic process (GO:0044598)2.49966494
141daunorubicin metabolic process (GO:0044597)2.49966494
142polyketide metabolic process (GO:0030638)2.49966494
143regulation of cholesterol storage (GO:0010885)2.48781075
144positive regulation of fatty acid biosynthetic process (GO:0045723)2.48530404
145hydrogen peroxide biosynthetic process (GO:0050665)2.45261425
146negative regulation of coagulation (GO:0050819)2.45169519
147lipoprotein transport (GO:0042953)2.44056088
148regulation of humoral immune response (GO:0002920)2.42339190
149lipid storage (GO:0019915)2.41463466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.48238295
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.59375741
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.95989015
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.74987679
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.67335740
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.54716279
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.38079660
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.49349163
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.44640198
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60575013
11CLOCK_20551151_ChIP-Seq_293T_Human2.17743589
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04114032
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5367943
14DROSHA_22980978_ChIP-Seq_HELA_Human1.96652377
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94756258
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93102841
17EZH2_22144423_ChIP-Seq_EOC_Human1.85384699
18GATA1_22025678_ChIP-Seq_K562_Human1.80272250
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65066928
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65066572
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60189376
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.58476020
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49824211
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.45679868
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43902022
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.42079496
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41136689
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40611764
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37463835
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36684384
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33478454
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31757487
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27827724
34ZNF263_19887448_ChIP-Seq_K562_Human1.26197671
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25636698
36* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24685219
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.21648107
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.21531459
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20786490
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20651726
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17616933
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16614524
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16301617
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14369817
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13982399
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13982399
47* LXR_22292898_ChIP-Seq_THP-1_Human1.13818827
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13459207
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12630169
50CTCF_27219007_Chip-Seq_Bcells_Human1.11139341
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10564906
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08502737
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08293761
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04612923
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03670437
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03000513
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.01319294
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.01093209
59ESR1_20079471_ChIP-ChIP_T-47D_Human0.98041085
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97540425
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97474748
62BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96108884
63* GATA4_25053715_ChIP-Seq_YYC3_Human0.94742929
64* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94325483
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93232373
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92605944
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92059820
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91666814
69* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89477547
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88935351
71SMC4_20622854_ChIP-Seq_HELA_Human0.86788393
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86500312
73RACK7_27058665_Chip-Seq_MCF-7_Human0.86362179
74SOX2_20726797_ChIP-Seq_SW620_Human0.85808278
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85762262
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85396950
77EED_16625203_ChIP-ChIP_MESCs_Mouse0.85309486
78WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85164913
79RNF2_27304074_Chip-Seq_ESCs_Mouse0.84925179
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84860971
81ESR1_21235772_ChIP-Seq_MCF-7_Human0.84543580
82MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84123301
83HTT_18923047_ChIP-ChIP_STHdh_Human0.84011339
84REST_21632747_ChIP-Seq_MESCs_Mouse0.83150096
85SA1_27219007_Chip-Seq_Bcells_Human0.82971058
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82685312
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82592161
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82554460
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82031124
90* GATA2_21666600_ChIP-Seq_HMVEC_Human0.80491119
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80386305
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80367769
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79429947
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79318590
95BCAT_22108803_ChIP-Seq_LS180_Human0.78895677
96SCL_19346495_ChIP-Seq_HPC-7_Human0.78691445
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.78594999
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78567042
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78308336
100* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78132653
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77591526
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77449928
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77417301
104* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77240942
105* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76573519
106* GATA1_19941827_ChIP-Seq_MEL_Mouse0.76102073
107GATA1_19941826_ChIP-Seq_K562_Human0.74038218
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73118782
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.73102866
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.71577845
111* KDM2B_26808549_Chip-Seq_K562_Human0.71333863
112KLF4_19829295_ChIP-Seq_ESCs_Human0.71052196
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.70390158
114GATA6_25053715_ChIP-Seq_YYC3_Human0.70104136
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.70054728
116VDR_24787735_ChIP-Seq_THP-1_Human0.70051254
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69981967
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69681877
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.69069422
120TP63_22573176_ChIP-Seq_HFKS_Human0.68705708
121OCT4_19829295_ChIP-Seq_ESCs_Human0.68296620
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68038830
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67884647
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.67218384
125GATA2_19941826_ChIP-Seq_K562_Human0.67072068
126BCOR_27268052_Chip-Seq_Bcells_Human0.66389707
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65798154
128RARB_24833708_ChIP-Seq_LIVER_Mouse0.65338489
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65099831
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64737396
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64697974
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.64036032
133VDR_21846776_ChIP-Seq_THP-1_Human0.63898482
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63643753
135BCL6_27268052_Chip-Seq_Bcells_Human0.62973998
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62549785
137* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.62245959
138* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62160155
139ATF3_27146783_Chip-Seq_COLON_Human0.61458492
140* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58462652
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.58278053
142* CEBPB_22108803_ChIP-Seq_LS180_Human0.58204817
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.57170296
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.57170296
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57101460
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56855844
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.56497808
148TCF7_22412390_ChIP-Seq_EML_Mouse0.56428272
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.55830562
150EGR1_19032775_ChIP-ChIP_M12_Human0.55773857
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55329374
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.55125324
153CTCF_21964334_ChIP-Seq_BJAB-B_Human0.53976771
154MAF_26560356_Chip-Seq_TH1_Human0.53196651
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53048561
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53019086
157SPI1_20517297_ChIP-Seq_HL60_Human0.52135049
158CTCF_21964334_Chip-Seq_Bcells_Human0.51316302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.53997773
2MP0005360_urolithiasis6.90243747
3MP0005365_abnormal_bile_salt5.61869340
4MP0005085_abnormal_gallbladder_physiolo5.59950160
5MP0008875_abnormal_xenobiotic_pharmacok4.82427085
6MP0003806_abnormal_nucleotide_metabolis3.83958056
7MP0010329_abnormal_lipoprotein_level3.49059046
8MP0003252_abnormal_bile_duct3.46918704
9MP0009840_abnormal_foam_cell3.40280024
10MP0005083_abnormal_biliary_tract2.86777217
11MP0005332_abnormal_amino_acid2.70901010
12MP0003191_abnormal_cellular_cholesterol2.69718933
13MP0001666_abnormal_nutrient_absorption2.40179755
14MP0003195_calcinosis2.36479075
15MP0000609_abnormal_liver_physiology2.16178179
16MP0002118_abnormal_lipid_homeostasis2.07954825
17MP0004019_abnormal_vitamin_homeostasis2.07170891
18MP0002138_abnormal_hepatobiliary_system1.98860012
19MP0005319_abnormal_enzyme/_coenzyme1.92706460
20MP0003879_abnormal_hair_cell1.85137501
21MP0003705_abnormal_hypodermis_morpholog1.76096661
22MP0001501_abnormal_sleep_pattern1.55909996
23MP0003868_abnormal_feces_composition1.55457666
24* MP0005584_abnormal_enzyme/coenzyme_acti1.53692593
25MP0001764_abnormal_homeostasis1.52230201
26MP0009643_abnormal_urine_homeostasis1.51604204
27MP0003186_abnormal_redox_activity1.46353309
28MP0003656_abnormal_erythrocyte_physiolo1.30156023
29MP0005670_abnormal_white_adipose1.28707418
30MP0004043_abnormal_pH_regulation1.25935500
31MP0000598_abnormal_liver_morphology1.24858579
32MP0009780_abnormal_chondrocyte_physiolo1.22759009
33MP0005451_abnormal_body_composition1.18551280
34MP0004130_abnormal_muscle_cell1.18252614
35MP0003011_delayed_dark_adaptation1.17179545
36MP0009764_decreased_sensitivity_to1.11576673
37MP0010368_abnormal_lymphatic_system1.09089330
38MP0009763_increased_sensitivity_to1.05312768
39MP0008469_abnormal_protein_level1.03897502
40MP0003828_pulmonary_edema1.01763489
41MP0002909_abnormal_adrenal_gland1.01110266
42MP0000604_amyloidosis1.00747671
43MP0005647_abnormal_sex_gland0.99452324
44MP0005636_abnormal_mineral_homeostasis0.99242504
45MP0002254_reproductive_system_inflammat0.98086518
46MP0002064_seizures0.98039511
47MP0000751_myopathy0.96137004
48MP0006138_congestive_heart_failure0.95595945
49MP0005058_abnormal_lysosome_morphology0.95463788
50MP0001958_emphysema0.95333993
51MP0003633_abnormal_nervous_system0.93915692
52MP0005666_abnormal_adipose_tissue0.90302989
53MP0002971_abnormal_brown_adipose0.89995560
54MP0009642_abnormal_blood_homeostasis0.89551812
55MP0009697_abnormal_copulation0.89034789
56MP0005464_abnormal_platelet_physiology0.88881475
57MP0003436_decreased_susceptibility_to0.88297381
58MP0000920_abnormal_myelination0.88083632
59MP0003183_abnormal_peptide_metabolism0.85486976
60MP0005595_abnormal_vascular_smooth0.85064477
61MP0001756_abnormal_urination0.84446451
62MP0009745_abnormal_behavioral_response0.84010460
63MP0004270_analgesia0.82146899
64MP0001440_abnormal_grooming_behavior0.82065312
65MP0003646_muscle_fatigue0.81922214
66* MP0006036_abnormal_mitochondrial_physio0.81287793
67MP0003724_increased_susceptibility_to0.79584435
68MP0005334_abnormal_fat_pad0.79159315
69MP0006082_CNS_inflammation0.78911219
70MP0003300_gastrointestinal_ulcer0.77594200
71MP0005164_abnormal_response_to0.77056988
72MP0005376_homeostasis/metabolism_phenot0.76589898
73MP0001986_abnormal_taste_sensitivity0.74991621
74MP0002638_abnormal_pupillary_reflex0.74966920
75MP0004215_abnormal_myocardial_fiber0.74873227
76MP0002136_abnormal_kidney_physiology0.74232713
77MP0002078_abnormal_glucose_homeostasis0.74163621
78MP0003959_abnormal_lean_body0.73976815
79MP0000230_abnormal_systemic_arterial0.73521792
80MP0002332_abnormal_exercise_endurance0.72997292
81MP0005165_increased_susceptibility_to0.70972810
82MP0009765_abnormal_xenobiotic_induced0.70055584
83MP0001533_abnormal_skeleton_physiology0.69697723
84MP0005220_abnormal_exocrine_pancreas0.69635126
85MP0003631_nervous_system_phenotype0.69084284
86MP0002837_dystrophic_cardiac_calcinosis0.68002526
87MP0004859_abnormal_synaptic_plasticity0.66007245
88MP0004782_abnormal_surfactant_physiolog0.65930977
89MP0002133_abnormal_respiratory_system0.65433664
90MP0005388_respiratory_system_phenotype0.65433664
91MP0003075_altered_response_to0.63972372
92MP0002733_abnormal_thermal_nociception0.63651345
93MP0005408_hypopigmentation0.63493011
94MP0001544_abnormal_cardiovascular_syste0.63168909
95MP0005385_cardiovascular_system_phenoty0.63168909
96MP0001486_abnormal_startle_reflex0.62913901
97MP0004883_abnormal_blood_vessel0.62773808
98MP0005084_abnormal_gallbladder_morpholo0.62434389
99MP0001661_extended_life_span0.62425865
100MP0001853_heart_inflammation0.60885906
101MP0003690_abnormal_glial_cell0.60455605
102MP0002998_abnormal_bone_remodeling0.60048933
103MP0003638_abnormal_response/metabolism_0.59989049
104MP0005535_abnormal_body_temperature0.59644298
105MP0005266_abnormal_metabolism0.59555569
106MP0004185_abnormal_adipocyte_glucose0.59056250
107MP0009115_abnormal_fat_cell0.57636819
108MP0009053_abnormal_anal_canal0.56503965
109MP0005167_abnormal_blood-brain_barrier0.56354426
110MP0000249_abnormal_blood_vessel0.54385340
111MP0003303_peritoneal_inflammation0.53744381
112MP0001845_abnormal_inflammatory_respons0.52398066
113MP0008438_abnormal_cutaneous_collagen0.51708507
114MP0005448_abnormal_energy_balance0.51569367
115MP0005166_decreased_susceptibility_to0.51280428
116MP0010234_abnormal_vibrissa_follicle0.51163751
117MP0005023_abnormal_wound_healing0.50711644
118MP0002970_abnormal_white_adipose0.49955015
119MP0008873_increased_physiological_sensi0.49720635
120MP0000639_abnormal_adrenal_gland0.49545206
121MP0003329_amyloid_beta_deposits0.47996720
122MP0002796_impaired_skin_barrier0.46858006
123MP0006035_abnormal_mitochondrial_morpho0.45186521
124MP0002928_abnormal_bile_duct0.44984879
125MP0002060_abnormal_skin_morphology0.44353346
126MP0000685_abnormal_immune_system0.44080022
127MP0002135_abnormal_kidney_morphology0.43719691
128MP0002876_abnormal_thyroid_physiology0.43312042
129MP0008874_decreased_physiological_sensi0.42640551
130MP0002168_other_aberrant_phenotype0.42118831
131MP0004947_skin_inflammation0.42056303
132MP0002419_abnormal_innate_immunity0.41225636
133MP0003566_abnormal_cell_adhesion0.41182278
134MP0005025_abnormal_response_to0.41057700
135MP0000343_altered_response_to0.40286943
136MP0005375_adipose_tissue_phenotype0.40185347
137MP0009785_altered_susceptibility_to0.39720796
138MP0001765_abnormal_ion_homeostasis0.39486579

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.78939575
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53780390
3Intrahepatic cholestasis (HP:0001406)6.31100927
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.01017850
5Xanthomatosis (HP:0000991)5.86574357
6Prolonged partial thromboplastin time (HP:0003645)5.44705836
7Hypobetalipoproteinemia (HP:0003563)5.43089408
8Complement deficiency (HP:0004431)5.14302677
9Hyperlipoproteinemia (HP:0010980)5.04147919
10Hyperammonemia (HP:0001987)4.54638305
11Joint hemorrhage (HP:0005261)4.27897909
12Ketosis (HP:0001946)4.25056945
13Hypolipoproteinemia (HP:0010981)4.22658127
14Hyperglycinuria (HP:0003108)4.21499215
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13633439
16Hyperglycinemia (HP:0002154)4.11344409
17Abnormality of the common coagulation pathway (HP:0010990)4.02413016
18Abnormality of serine family amino acid metabolism (HP:0010894)4.01328664
19Abnormality of glycine metabolism (HP:0010895)4.01328664
20Epidermoid cyst (HP:0200040)3.95145416
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93258127
22Abnormality of complement system (HP:0005339)3.90272186
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.87297926
24Hypoalphalipoproteinemia (HP:0003233)3.85895411
25Hypoglycemic coma (HP:0001325)3.74504514
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.68823017
27Abnormality of fatty-acid metabolism (HP:0004359)3.61958426
28Fat malabsorption (HP:0002630)3.59336939
29Abnormality of methionine metabolism (HP:0010901)3.55302289
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45417573
31Hypercholesterolemia (HP:0003124)3.43222439
32Abnormality of the intrinsic pathway (HP:0010989)3.40617125
33Abnormality of pyrimidine metabolism (HP:0004353)3.37216708
34Ketoacidosis (HP:0001993)3.17468159
35Systemic lupus erythematosus (HP:0002725)3.09913438
36Abnormality of nucleobase metabolism (HP:0010932)3.06330961
37Hyperbilirubinemia (HP:0002904)3.02931215
38Myocardial infarction (HP:0001658)3.02302996
39Delayed CNS myelination (HP:0002188)3.00353110
40Abnormality of purine metabolism (HP:0004352)2.90888087
41Conjugated hyperbilirubinemia (HP:0002908)2.90082376
42Oligomenorrhea (HP:0000876)2.84206047
43Dicarboxylic aciduria (HP:0003215)2.79809854
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79809854
45Abnormality of serum amino acid levels (HP:0003112)2.78692019
46Metabolic acidosis (HP:0001942)2.74974136
47Decreased circulating renin level (HP:0003351)2.74947057
48Steatorrhea (HP:0002570)2.74679505
49Gout (HP:0001997)2.74419108
50Hepatocellular carcinoma (HP:0001402)2.73696934
51Recurrent gram-negative bacterial infections (HP:0005420)2.68879031
52Spastic diplegia (HP:0001264)2.67754347
53Neurofibrillary tangles (HP:0002185)2.64880205
54Skin nodule (HP:0200036)2.63724621
55Glomerulonephritis (HP:0000099)2.52620092
56Vascular calcification (HP:0004934)2.52534455
57Esophageal varix (HP:0002040)2.50299671
58Spontaneous abortion (HP:0005268)2.49739226
59Abnormality of liposaccharide metabolism (HP:0010968)2.45229952
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.45229952
61Abnormality of glycolipid metabolism (HP:0010969)2.45229952
62Mutism (HP:0002300)2.43630585
63Lethargy (HP:0001254)2.43567757
64Muscle fiber splitting (HP:0003555)2.39109401
65Neonatal onset (HP:0003623)2.36048003
66Mitral stenosis (HP:0001718)2.33783563
67Abnormality of the periventricular white matter (HP:0002518)2.32040936
68Malnutrition (HP:0004395)2.30982179
69Generalized aminoaciduria (HP:0002909)2.30334063
70Amyloidosis (HP:0011034)2.29656162
71Cardiovascular calcification (HP:0011915)2.28932151
72Increased cerebral lipofuscin (HP:0011813)2.28639723
73Atrioventricular block (HP:0001678)2.27801199
74Late onset (HP:0003584)2.26887106
75Abnormal eating behavior (HP:0100738)2.26763280
76Cholelithiasis (HP:0001081)2.23913461
77Menorrhagia (HP:0000132)2.21563777
78Dysostosis multiplex (HP:0000943)2.20962580
79Abnormal gallbladder morphology (HP:0012437)2.20804572
80Purpura (HP:0000979)2.20211770
81Gingival bleeding (HP:0000225)2.19048405
82Hydroxyprolinuria (HP:0003080)2.18979792
83Abnormality of proline metabolism (HP:0010907)2.18979792
84Heart block (HP:0012722)2.18032170
85Abnormality of renin-angiotensin system (HP:0000847)2.17368887
86Abnormal cartilage morphology (HP:0002763)2.17082202
87Hypochromic microcytic anemia (HP:0004840)2.15924809
88Irritability (HP:0000737)2.15262935
89Abnormality of polysaccharide metabolism (HP:0011012)2.14579661
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14579661
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14579661
92Pancreatitis (HP:0001733)2.14307082
93Abnormal gallbladder physiology (HP:0012438)2.14056198
94Cholecystitis (HP:0001082)2.14056198
95Hemorrhage of the eye (HP:0011885)2.13544833
96Sensorimotor neuropathy (HP:0007141)2.13366891
97Cerebral inclusion bodies (HP:0100314)2.12380481
98Asymmetric septal hypertrophy (HP:0001670)2.11186696
99Vomiting (HP:0002013)2.10970624
100Thrombophlebitis (HP:0004418)2.09464755
101Urinary glycosaminoglycan excretion (HP:0003541)2.08408652
102Mucopolysacchariduria (HP:0008155)2.08408652
103Axonal loss (HP:0003447)2.08027201
104Acanthosis nigricans (HP:0000956)2.07859788
105Acanthocytosis (HP:0001927)2.07684302
106Retinal atrophy (HP:0001105)2.07398600
107Pigmentary retinal degeneration (HP:0001146)2.06965001
108Polycythemia (HP:0001901)2.05840479
109Abnormal atrioventricular conduction (HP:0005150)2.04811763
110Nephritis (HP:0000123)2.04061471
111Hypoglycemic seizures (HP:0002173)2.03931502
112Abnormality of iron homeostasis (HP:0011031)2.03929554
113Polyphagia (HP:0002591)2.02888515
114Cerebral edema (HP:0002181)2.02844405
115Abnormality of transition element cation homeostasis (HP:0011030)2.01847683
116Hyperactive renin-angiotensin system (HP:0000841)2.00906351
117Hypertriglyceridemia (HP:0002155)1.98383201
118Cerebral palsy (HP:0100021)1.97934952
119Brushfield spots (HP:0001088)1.95677791
120Rickets (HP:0002748)1.95440777
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.92239499
122Increased purine levels (HP:0004368)1.88993365
123Hyperuricemia (HP:0002149)1.88993365
124Ventricular fibrillation (HP:0001663)1.88046542
125Proximal tubulopathy (HP:0000114)1.87948235
126Interstitial pulmonary disease (HP:0006530)1.87231587
127Alkalosis (HP:0001948)1.87190960
128Nausea (HP:0002018)1.87040878
129Pulmonary embolism (HP:0002204)1.83645554
130Abnormal enzyme/coenzyme activity (HP:0012379)1.83529092
131Abnormality of the gallbladder (HP:0005264)1.83433774
132Myokymia (HP:0002411)1.83122966
133Opisthotonus (HP:0002179)1.82804740
134Eczematoid dermatitis (HP:0000976)1.82549769
135Bundle branch block (HP:0011710)1.80045141
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79113672
137Hyperaldosteronism (HP:0000859)1.79003733
138Metabolic alkalosis (HP:0200114)1.78011994
139Polygenic inheritance (HP:0010982)1.76628411
140Increased serum ferritin (HP:0003281)1.75379231
141Elevated hepatic transaminases (HP:0002910)1.75035019
142Increased mean platelet volume (HP:0011877)1.74979555
143Syncope (HP:0001279)1.72477804
144Potter facies (HP:0002009)1.71305427
145Facial shape deformation (HP:0011334)1.71305427
146Poikilocytosis (HP:0004447)1.71227059
147Visceral angiomatosis (HP:0100761)1.61494347
148Exercise-induced myalgia (HP:0003738)1.60945068
149Hypokalemia (HP:0002900)1.59881485
150Bronchomalacia (HP:0002780)1.59518081
151Stroke (HP:0001297)1.58101481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.84887507
2ERN14.84648437
3SIK13.86811860
4TRIB33.83234074
5FGFR43.35907804
6PKN23.31421844
7TAOK32.35619511
8FLT32.32210982
9MST1R2.13506446
10NTRK31.96106244
11ACVR1B1.87681496
12PTK61.81297640
13RIPK41.81160247
14MAP2K31.80618451
15EPHA41.74404238
16TGFBR21.66576552
17TYK21.65543447
18RIPK11.64624262
19CAMK1D1.50948688
20MAPK111.50938761
21DDR21.48247225
22EPHB11.47152474
23EEF2K1.39431912
24ERBB41.37581537
25TIE11.36736461
26TBK11.36358522
27MAP3K101.35678939
28INSRR1.34417012
29KDR1.31919503
30MARK11.30489691
31GRK61.29567583
32OBSCN1.28899875
33EPHB21.28173001
34PIK3CG1.27781702
35CAMK11.26578826
36PRPF4B1.26523437
37LRRK21.22903958
38NEK91.22632331
39TTN1.18117016
40PHKG11.17017784
41PHKG21.17017784
42CAMKK11.15765329
43MAP3K131.12766996
44MAP3K31.11341984
45KIT1.11280587
46CAMKK21.10795490
47MAP2K41.10739907
48MAP3K71.10110493
49CSF1R1.08810074
50LATS11.06660637
51MAP3K111.06531341
52JAK21.06439223
53MAP4K11.04222874
54PRKAA21.02237757
55CDC42BPA1.02117572
56GRK51.01666807
57ABL20.99406934
58MARK20.95995060
59SGK4940.94141475
60SGK2230.94141475
61TNK20.93990431
62FES0.93317965
63CSK0.91510082
64JAK10.90876635
65CDK60.89161243
66PIK3CA0.87632388
67PAK60.84918010
68SGK20.82865748
69MAPKAPK30.80964082
70MAPK40.79186345
71MET0.78591706
72OXSR10.78283816
73DAPK20.77740430
74TESK10.77217170
75PKN10.75557205
76ADRBK20.75053404
77CAMK1G0.73843990
78MYLK0.73833755
79FER0.72531756
80MAPK70.72145971
81GRK70.71827459
82BTK0.71787167
83FRK0.71278525
84DYRK1B0.69319844
85CAMK40.69115116
86ZAP700.68401104
87NTRK20.67660464
88PDK30.67417752
89PDK40.67417752
90PDK20.66959945
91CAMK2G0.66621752
92IRAK30.66399063
93KSR20.66206986
94PRKD10.64517792
95MAPK120.64114892
96BLK0.63830556
97GRK10.63641966
98ADRBK10.63473944
99ARAF0.63047538
100TGFBR10.62964941
101CASK0.61611539
102CAMK2B0.61237434
103PTK20.61072438
104FGFR20.60295872
105PRKG10.60172941
106STK380.60008483
107PAK40.59502187
108CDK50.59241455
109PDGFRA0.58164096
110GSK3A0.56817632
111STK100.56792555
112CDK40.56562970
113MAP3K20.55913292
114CAMK2A0.55405578
115PDPK10.54503640
116BMX0.53456934
117SGK10.53178557
118MATK0.53131481
119PRKACA0.52485858
120MTOR0.52052177
121PINK10.51604466
122ERBB20.51295728
123MAP2K20.50383060
124FGFR30.50341023
125IKBKE0.49506739
126MAP2K60.49490383
127PRKACG0.48704019
128EPHA30.48213937
129NEK10.47717319
130PRKAA10.46429200
131RET0.45566995
132MAP2K10.45031788
133PRKCZ0.42649022
134JAK30.42248487
135NME20.41528201
136ICK0.40193158
137PRKG20.39984451
138MAP3K60.38464974
139MAPK150.35752124
140EGFR0.35663802
141EPHA20.34076441
142MAP3K10.33756176
143LMTK20.33163380
144PDK10.33054575
145PAK20.32760951
146IGF1R0.32445423
147MAP3K140.31633565
148SGK30.30473321
149MAP3K50.29035136
150MAP3K80.26998455

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.18652542
2Nitrogen metabolism_Homo sapiens_hsa009103.43748137
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20461975
4* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15431290
5Arginine biosynthesis_Homo sapiens_hsa002202.91288192
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66764205
7Complement and coagulation cascades_Homo sapiens_hsa046102.63623998
8* Fatty acid degradation_Homo sapiens_hsa000712.63334679
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59220689
10* Tryptophan metabolism_Homo sapiens_hsa003802.56100736
11* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50732846
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39729018
13Propanoate metabolism_Homo sapiens_hsa006402.21280928
14* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18710187
15Peroxisome_Homo sapiens_hsa041462.10877992
16Butanoate metabolism_Homo sapiens_hsa006502.09712587
17PPAR signaling pathway_Homo sapiens_hsa033202.08273402
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07064462
19Caffeine metabolism_Homo sapiens_hsa002322.06103279
20Fatty acid metabolism_Homo sapiens_hsa012122.01998780
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90625165
22Chemical carcinogenesis_Homo sapiens_hsa052041.88565927
23Staphylococcus aureus infection_Homo sapiens_hsa051501.88494054
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87471200
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.73967005
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.73831404
27* beta-Alanine metabolism_Homo sapiens_hsa004101.64207715
28Selenocompound metabolism_Homo sapiens_hsa004501.59532538
29* Histidine metabolism_Homo sapiens_hsa003401.58883587
30Retinol metabolism_Homo sapiens_hsa008301.58344356
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55588178
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54611933
33Phenylalanine metabolism_Homo sapiens_hsa003601.48223339
34Bile secretion_Homo sapiens_hsa049761.48103518
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42164132
36Starch and sucrose metabolism_Homo sapiens_hsa005001.39081874
37Carbon metabolism_Homo sapiens_hsa012001.38770041
38* Pyruvate metabolism_Homo sapiens_hsa006201.37887111
39Biosynthesis of amino acids_Homo sapiens_hsa012301.32596902
40Sulfur metabolism_Homo sapiens_hsa009201.32515000
41Tyrosine metabolism_Homo sapiens_hsa003501.32393932
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28438336
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26479359
44Folate biosynthesis_Homo sapiens_hsa007901.24894333
45Fat digestion and absorption_Homo sapiens_hsa049751.20772343
46Fatty acid elongation_Homo sapiens_hsa000621.19845218
47ABC transporters_Homo sapiens_hsa020101.19668189
48Sulfur relay system_Homo sapiens_hsa041221.17448554
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.08816143
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08078002
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99809281
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97667119
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92905450
54Vitamin digestion and absorption_Homo sapiens_hsa049770.87835961
55Mineral absorption_Homo sapiens_hsa049780.87407987
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84523849
57Pentose phosphate pathway_Homo sapiens_hsa000300.84079068
58Steroid biosynthesis_Homo sapiens_hsa001000.82852728
59Glutathione metabolism_Homo sapiens_hsa004800.80585149
60* Arginine and proline metabolism_Homo sapiens_hsa003300.79865680
61* Lysine degradation_Homo sapiens_hsa003100.78600343
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78468397
63* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77380408
64Fatty acid biosynthesis_Homo sapiens_hsa000610.73483760
65One carbon pool by folate_Homo sapiens_hsa006700.71412439
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.70484108
67Vitamin B6 metabolism_Homo sapiens_hsa007500.70288616
68* Glycerolipid metabolism_Homo sapiens_hsa005610.69432603
69Renin secretion_Homo sapiens_hsa049240.54855547
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53926051
71Asthma_Homo sapiens_hsa053100.52838242
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50869844
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.49714986
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.42994849
75* Metabolic pathways_Homo sapiens_hsa011000.42622853
76Insulin resistance_Homo sapiens_hsa049310.41365925
77Galactose metabolism_Homo sapiens_hsa000520.41028683
78Fructose and mannose metabolism_Homo sapiens_hsa000510.40813288
79Gastric acid secretion_Homo sapiens_hsa049710.38136500
80Ether lipid metabolism_Homo sapiens_hsa005650.36774459
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35862726
82Insulin secretion_Homo sapiens_hsa049110.35340517
83Circadian entrainment_Homo sapiens_hsa047130.32640938
84Serotonergic synapse_Homo sapiens_hsa047260.32076148
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31676187
86GABAergic synapse_Homo sapiens_hsa047270.31228516
87Morphine addiction_Homo sapiens_hsa050320.29792603
88Pancreatic secretion_Homo sapiens_hsa049720.29551110
89Glutamatergic synapse_Homo sapiens_hsa047240.28994831
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.28618857
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28508208
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28436895
93Salivary secretion_Homo sapiens_hsa049700.27842106
94Prion diseases_Homo sapiens_hsa050200.26346407
95Cocaine addiction_Homo sapiens_hsa050300.24624408
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.23284907
97Allograft rejection_Homo sapiens_hsa053300.22823006
98Synaptic vesicle cycle_Homo sapiens_hsa047210.22627051
99Autoimmune thyroid disease_Homo sapiens_hsa053200.20275883
100Phagosome_Homo sapiens_hsa041450.20253268
101AMPK signaling pathway_Homo sapiens_hsa041520.16643645
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16038135
103Glucagon signaling pathway_Homo sapiens_hsa049220.10656167
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.09353761
105Linoleic acid metabolism_Homo sapiens_hsa005910.09344488
106Other glycan degradation_Homo sapiens_hsa005110.08732478
107Renin-angiotensin system_Homo sapiens_hsa046140.02666595
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02514696
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.02506256
110Insulin signaling pathway_Homo sapiens_hsa049100.02501110
111Lysosome_Homo sapiens_hsa041420.00735622
112Protein digestion and absorption_Homo sapiens_hsa04974-0.1667283
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1630814
114Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1622992
115Acute myeloid leukemia_Homo sapiens_hsa05221-0.1482155
116Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1451622
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1350335
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1190924
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1125652
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1010882
121Hepatitis C_Homo sapiens_hsa05160-0.0801384
122Amoebiasis_Homo sapiens_hsa05146-0.0656113
123Pertussis_Homo sapiens_hsa05133-0.0642637
124Bladder cancer_Homo sapiens_hsa05219-0.0587850
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0485972
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0443473

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