ALDH3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)9.83096244
2keratinization (GO:0031424)9.17540270
3ethanol oxidation (GO:0006069)8.94462125
4polyketide metabolic process (GO:0030638)8.69720368
5doxorubicin metabolic process (GO:0044598)8.69720368
6daunorubicin metabolic process (GO:0044597)8.69720368
7primary alcohol catabolic process (GO:0034310)8.07571923
8axoneme assembly (GO:0035082)7.74278165
9aminoglycoside antibiotic metabolic process (GO:0030647)7.70872963
10left/right pattern formation (GO:0060972)7.55834756
11vitamin transmembrane transport (GO:0035461)7.42963890
12hemidesmosome assembly (GO:0031581)7.39523313
13vitamin A metabolic process (GO:0006776)7.38542275
14ethanol metabolic process (GO:0006067)7.07696048
15terpenoid biosynthetic process (GO:0016114)7.01185108
16desmosome organization (GO:0002934)6.88776322
17regulation of skeletal muscle contraction (GO:0014819)6.73165294
18one-carbon compound transport (GO:0019755)6.17091376
19progesterone metabolic process (GO:0042448)6.15043712
20bundle of His cell to Purkinje myocyte communication (GO:0086069)6.09570298
21xenobiotic catabolic process (GO:0042178)6.01994967
22negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.95150039
23pyrimidine-containing compound transmembrane transport (GO:0072531)5.93081001
24retinol metabolic process (GO:0042572)5.70289125
25multicellular organismal water homeostasis (GO:0050891)5.59550584
26positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.55612663
27regulation of cilium movement (GO:0003352)5.51015175
28lung epithelium development (GO:0060428)5.39173619
29establishment of skin barrier (GO:0061436)5.28357402
30glutathione derivative biosynthetic process (GO:1901687)5.25126360
31glutathione derivative metabolic process (GO:1901685)5.25126360
32peptide cross-linking (GO:0018149)5.23909167
33tolerance induction (GO:0002507)5.23825417
34renal absorption (GO:0070293)5.22958623
35regulation of water loss via skin (GO:0033561)5.10885292
36microtubule bundle formation (GO:0001578)5.04486387
37regulation of keratinocyte differentiation (GO:0045616)5.03381924
38retinoic acid metabolic process (GO:0042573)4.68327808
39intraciliary transport (GO:0042073)4.67727192
40glomerular epithelial cell development (GO:0072310)4.66254221
41water homeostasis (GO:0030104)4.59741255
42ventricular system development (GO:0021591)4.56573098
43L-ascorbic acid metabolic process (GO:0019852)4.53067844
44regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.47747486
45left/right axis specification (GO:0070986)4.47621965
46negative regulation of immunoglobulin mediated immune response (GO:0002890)4.39063892
47negative regulation of B cell mediated immunity (GO:0002713)4.39063892
48extracellular fibril organization (GO:0043206)4.34632799
49keratinocyte differentiation (GO:0030216)4.33749774
50cilium organization (GO:0044782)4.33722668
51negative regulation of T cell differentiation in thymus (GO:0033085)4.32075622
52C21-steroid hormone metabolic process (GO:0008207)4.27960491
53cilium assembly (GO:0042384)4.23031526
54positive regulation of tolerance induction (GO:0002645)4.21482505
55negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.15147381
56retinal metabolic process (GO:0042574)4.12252331
57glycoside metabolic process (GO:0016137)4.11783711
58response to xenobiotic stimulus (GO:0009410)4.08237492
59surfactant homeostasis (GO:0043129)4.06076770
60establishment or maintenance of monopolar cell polarity (GO:0061339)4.05160234
61establishment of monopolar cell polarity (GO:0061162)4.05160234
62sperm capacitation (GO:0048240)3.88328053
63primary alcohol metabolic process (GO:0034308)3.87383583
64fibril organization (GO:0097435)3.81650413
65extracellular negative regulation of signal transduction (GO:1900116)3.77968446
66extracellular regulation of signal transduction (GO:1900115)3.77968446
67negative regulation of humoral immune response (GO:0002921)3.77876180
68centriole assembly (GO:0098534)3.77461832
69regulation of cardioblast proliferation (GO:0003264)3.75829910
70regulation of secondary heart field cardioblast proliferation (GO:0003266)3.75829910
71regulation of phospholipase A2 activity (GO:0032429)3.73174694
72protein localization to cilium (GO:0061512)3.70306946
73response to nitrosative stress (GO:0051409)3.62344723
74lipoxygenase pathway (GO:0019372)3.52641112
75establishment of tissue polarity (GO:0007164)3.51466893
76establishment of planar polarity (GO:0001736)3.51466893
77epithelial cell-cell adhesion (GO:0090136)3.50237502
78hydrogen peroxide biosynthetic process (GO:0050665)3.49035677
79regulation of germinal center formation (GO:0002634)3.46924182
80regulation of female gonad development (GO:2000194)3.43750429
81quinone metabolic process (GO:1901661)3.42524135
82microtubule-based movement (GO:0007018)3.41053678
83gas transport (GO:0015669)3.36070378
84atrioventricular valve morphogenesis (GO:0003181)3.35374814
85ear development (GO:0043583)3.33157037
86interferon-gamma secretion (GO:0072643)3.30426083
87cellular component assembly involved in morphogenesis (GO:0010927)3.29867047
88chemical homeostasis within a tissue (GO:0048875)3.28646862
89regulation of epidermal cell differentiation (GO:0045604)3.20180348
90cell projection assembly (GO:0030031)3.19917514
91epidermal cell differentiation (GO:0009913)3.18437525
92intermediate filament organization (GO:0045109)3.18160026
93oligosaccharide biosynthetic process (GO:0009312)3.17189262
94cytoplasmic microtubule organization (GO:0031122)3.16635774
95flavonoid metabolic process (GO:0009812)3.13007361
96ectoderm development (GO:0007398)3.12502702
97antibacterial humoral response (GO:0019731)3.12353441
98regulation of keratinocyte proliferation (GO:0010837)3.12131017
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11808724
100regulation of interleukin-5 production (GO:0032674)3.11266962
101positive regulation of steroid biosynthetic process (GO:0010893)3.09255297
102lateral sprouting from an epithelium (GO:0060601)3.08980214
103protein O-linked glycosylation (GO:0006493)3.08814773
104O-glycan processing (GO:0016266)3.08587334
105reactive oxygen species biosynthetic process (GO:1903409)3.08380570
106regulation of epidermis development (GO:0045682)3.08054877
107regulation of microtubule-based movement (GO:0060632)3.07191317
108apical protein localization (GO:0045176)3.07092788
109regulation of tolerance induction (GO:0002643)3.05337574
110positive regulation of osteoblast proliferation (GO:0033690)3.04865473
111cell wall macromolecule metabolic process (GO:0044036)3.00879540
112cell wall macromolecule catabolic process (GO:0016998)3.00879540
113cilium morphogenesis (GO:0060271)2.98471351
114exogenous drug catabolic process (GO:0042738)2.93762091
115negative regulation of complement activation (GO:0045916)2.91605530
116antimicrobial humoral response (GO:0019730)2.91408835
117pentose-phosphate shunt (GO:0006098)2.90551406
118* cellular aldehyde metabolic process (GO:0006081)2.90534947
119microtubule depolymerization (GO:0007019)2.90175809
120epidermis development (GO:0008544)2.89231994
121glutathione biosynthetic process (GO:0006750)2.88532457
122innate immune response in mucosa (GO:0002227)2.87311089
123positive regulation of vesicle fusion (GO:0031340)2.87270425
124negative regulation of epidermal cell differentiation (GO:0045605)2.86077813
125lymph vessel development (GO:0001945)2.85992865
126positive regulation of smoothened signaling pathway (GO:0045880)2.85789215
127long-chain fatty acid biosynthetic process (GO:0042759)2.85214411
128linoleic acid metabolic process (GO:0043651)2.84107500
129nucleoside diphosphate phosphorylation (GO:0006165)2.82075217
130negative regulation of epidermis development (GO:0045683)2.80796858
131retinoid metabolic process (GO:0001523)2.79836013
132hormone catabolic process (GO:0042447)2.78342338
133excretion (GO:0007588)2.75135232
134negative regulation of keratinocyte proliferation (GO:0010839)2.73447811
135cellular response to arsenic-containing substance (GO:0071243)2.71752134
136positive regulation of extracellular matrix organization (GO:1903055)2.71481197
137cellular hormone metabolic process (GO:0034754)2.70309124
138cysteine metabolic process (GO:0006534)2.69986456
139keratinocyte proliferation (GO:0043616)2.69677747
140outer ear morphogenesis (GO:0042473)2.69609928
141arachidonic acid secretion (GO:0050482)2.69558392
142icosanoid secretion (GO:0032309)2.69558392
143apoptotic cell clearance (GO:0043277)2.69379908
144positive regulation of hair follicle development (GO:0051798)2.68522614
145positive regulation of hair cycle (GO:0042635)2.68522614
146positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67000508
147glutathione metabolic process (GO:0006749)2.66065740
148diterpenoid metabolic process (GO:0016101)2.65962614
149calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.65336132
150lung lobe morphogenesis (GO:0060463)2.64596874
151negative regulation of chondrocyte differentiation (GO:0032331)2.64515638
152NADPH regeneration (GO:0006740)2.64120313
153melanin biosynthetic process (GO:0042438)2.63582981
154positive regulation of hormone biosynthetic process (GO:0046886)2.63296289
155mesodermal cell differentiation (GO:0048333)2.62809413
156nonribosomal peptide biosynthetic process (GO:0019184)2.62469109
157maintenance of gastrointestinal epithelium (GO:0030277)2.62390957
158response to vitamin A (GO:0033189)2.61761286
159nitric oxide biosynthetic process (GO:0006809)2.61153965
160skin development (GO:0043588)2.60882717
161cell-substrate junction assembly (GO:0007044)2.60408742
162detection of other organism (GO:0098543)2.57408215
163branching involved in salivary gland morphogenesis (GO:0060445)2.56987139
164establishment of apical/basal cell polarity (GO:0035089)2.56751854
165regulation of hair follicle development (GO:0051797)2.55012526
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.54894394
167negative regulation of cell fate commitment (GO:0010454)2.54517549
168regulation of hippo signaling (GO:0035330)2.53520453
169hair follicle morphogenesis (GO:0031069)2.52491088
170regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52311426
171membrane budding (GO:0006900)2.49636390
172ventricular cardiac muscle cell action potential (GO:0086005)2.48616138
173axonemal dynein complex assembly (GO:0070286)17.2970582
174cilium or flagellum-dependent cell motility (GO:0001539)13.0768459
175motile cilium assembly (GO:0044458)11.9832880
176cilium movement (GO:0003341)11.6564745
177epithelial cilium movement (GO:0003351)10.4922272
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.1780758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.99827106
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.72659725
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.00489163
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56186230
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.25101653
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.98040669
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.49960993
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34586986
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.28175906
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.21500884
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.21500884
12ZNF263_19887448_ChIP-Seq_K562_Human2.17024906
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.15092534
14DROSHA_22980978_ChIP-Seq_HELA_Human2.12628566
15CLOCK_20551151_ChIP-Seq_293T_Human2.05194818
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04825370
17* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04169272
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02846273
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.5284534
20P63_26484246_Chip-Seq_KERATINOCYTES_Human1.97913780
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93202898
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92749711
23SMC4_20622854_ChIP-Seq_HELA_Human1.92144146
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.91260823
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89788350
26SOX2_20726797_ChIP-Seq_SW620_Human1.85580624
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82805344
28CJUN_26792858_Chip-Seq_BT549_Human1.75397029
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68459798
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68459798
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.63342829
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61832248
33LXR_22292898_ChIP-Seq_THP-1_Human1.60756393
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59083750
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56351463
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55753653
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55248131
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53872721
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.53016042
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52437805
41AHR_22903824_ChIP-Seq_MCF-7_Human1.50295987
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48430306
43* KLF5_25053715_ChIP-Seq_YYC3_Human1.46819738
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45144989
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43523844
46CREB1_26743006_Chip-Seq_LNCaP_Human1.43161255
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42398507
48RACK7_27058665_Chip-Seq_MCF-7_Human1.42121723
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41546224
50P68_20966046_ChIP-Seq_HELA_Human1.40206112
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.39496161
52STAT1_20625510_ChIP-Seq_HELA_Human1.37904238
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33619747
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.33311049
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33103242
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30974469
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30862881
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28734634
59GATA4_25053715_ChIP-Seq_YYC3_Human1.28435779
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26915881
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26642132
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23345327
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21497191
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.21463164
65* TP53_18474530_ChIP-ChIP_U2OS_Human1.21057192
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.20969749
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19992328
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.19010112
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18100255
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17988371
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15208183
72* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14949726
73GATA1_19941826_ChIP-Seq_K562_Human1.13626237
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12431519
75CTCF_20526341_ChIP-Seq_ESCs_Human1.10216801
76ATF3_27146783_Chip-Seq_COLON_Human1.09501879
77PHF8_20622854_ChIP-Seq_HELA_Human1.09380049
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.09046507
79RXR_22108803_ChIP-Seq_LS180_Human1.08958911
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07151178
81* GATA6_25053715_ChIP-Seq_YYC3_Human1.07065467
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05650586
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.05242359
84* CTCF_27219007_Chip-Seq_Bcells_Human1.04071152
85TP63_23658742_ChIP-Seq_EP156T_Human1.03436643
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.01246955
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00824161
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00676734
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00161526
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99870752
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99144059
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99027359
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98946359
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97053839
95E2F1_20622854_ChIP-Seq_HELA_Human0.96920320
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96640754
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.96199127
98* TP53_16413492_ChIP-PET_HCT116_Human0.94064749
99* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92872265
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.92658469
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.92439966
102EGR1_19032775_ChIP-ChIP_M12_Human0.91828586
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91590481
104* TBX20_22080862_ChIP-Seq_HEART_Mouse0.91427825
105* TBX20_22328084_ChIP-Seq_HEART_Mouse0.91427825
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91390205
107* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91173055
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91145847
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90780949
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.90655890
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90402977
112BCOR_27268052_Chip-Seq_Bcells_Human0.90098246
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89835465
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87952901
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87647412
116CEBPB_22108803_ChIP-Seq_LS180_Human0.87017290
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86711444
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.85337944
119* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85309593
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85274532
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84886122
122GATA2_19941826_ChIP-Seq_K562_Human0.83004365
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82694741
124* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81981039
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81096954
126FLI1_21867929_ChIP-Seq_CD8_Mouse0.80551577
127ELF5_23300383_ChIP-Seq_T47D_Human0.80280752
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.80191737
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.80011897
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.77980527
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77775299
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.77768242
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.77595809
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77000476
135* TP53_22127205_ChIP-Seq_IMR90_Human0.76729671
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75490967
137TP63_22573176_ChIP-Seq_HFKS_Human0.73974993
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73941449
139SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73786384
140PPARA_22158963_ChIP-Seq_LIVER_Mouse0.73713980
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71559380
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.71424538
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.70747597
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70668239
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69871412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.24762905
2MP0009780_abnormal_chondrocyte_physiolo4.02187712
3MP0008004_abnormal_stomach_pH3.93965502
4MP0003011_delayed_dark_adaptation3.88497702
5MP0002796_impaired_skin_barrier3.85066115
6MP0005275_abnormal_skin_tensile3.66474480
7MP0000467_abnormal_esophagus_morphology3.32022813
8MP0008875_abnormal_xenobiotic_pharmacok3.09046706
9MP0002254_reproductive_system_inflammat3.05698146
10MP0010030_abnormal_orbit_morphology3.05403163
11MP0000762_abnormal_tongue_morphology3.05054241
12MP0001346_abnormal_lacrimal_gland2.91104084
13MP0000579_abnormal_nail_morphology2.84349133
14MP0004133_heterotaxia2.67420751
15MP0001984_abnormal_olfaction2.66381028
16MP0003941_abnormal_skin_development2.51957505
17MP0002877_abnormal_melanocyte_morpholog2.48297469
18MP0010234_abnormal_vibrissa_follicle2.46135818
19MP0004019_abnormal_vitamin_homeostasis2.39013035
20MP0008789_abnormal_olfactory_epithelium2.33733307
21MP0003705_abnormal_hypodermis_morpholog2.33327728
22MP0005501_abnormal_skin_physiology2.32432393
23MP0005623_abnormal_meninges_morphology2.29442759
24MP0003566_abnormal_cell_adhesion2.29383632
25MP0003806_abnormal_nucleotide_metabolis2.22785068
26MP0003453_abnormal_keratinocyte_physiol2.19362145
27MP0002060_abnormal_skin_morphology2.18074744
28MP0000383_abnormal_hair_follicle2.16588381
29MP0002234_abnormal_pharynx_morphology2.15680170
30MP0004381_abnormal_hair_follicle2.04686714
31MP0001216_abnormal_epidermal_layer1.96586478
32MP0002098_abnormal_vibrissa_morphology1.93435308
33MP0010678_abnormal_skin_adnexa1.91731247
34MP0002139_abnormal_hepatobiliary_system1.88578706
35MP0003656_abnormal_erythrocyte_physiolo1.84338086
36MP0000372_irregular_coat_pigmentation1.83545617
37MP0002168_other_aberrant_phenotype1.74911977
38MP0000537_abnormal_urethra_morphology1.74022623
39MP0005248_abnormal_Harderian_gland1.73918490
40MP0009379_abnormal_foot_pigmentation1.68110824
41MP0003186_abnormal_redox_activity1.67483141
42MP0010771_integument_phenotype1.59272504
43MP0003136_yellow_coat_color1.56275590
44MP0000470_abnormal_stomach_morphology1.53734098
45MP0000647_abnormal_sebaceous_gland1.53425299
46MP0004264_abnormal_extraembryonic_tissu1.52843473
47MP0000371_diluted_coat_color1.51446343
48MP0000566_synostosis1.49351322
49MP0001849_ear_inflammation1.46450960
50MP0003878_abnormal_ear_physiology1.46360093
51MP0005377_hearing/vestibular/ear_phenot1.46360093
52MP0001765_abnormal_ion_homeostasis1.45590110
53MP0005409_darkened_coat_color1.44703126
54MP0010155_abnormal_intestine_physiology1.42605188
55MP0005499_abnormal_olfactory_system1.41504371
56MP0005394_taste/olfaction_phenotype1.41504371
57MP0004272_abnormal_basement_membrane1.41118346
58MP0000858_altered_metastatic_potential1.38422298
59MP0004782_abnormal_surfactant_physiolog1.37412253
60MP0000678_abnormal_parathyroid_gland1.31985169
61MP0000516_abnormal_urinary_system1.24332072
62MP0005367_renal/urinary_system_phenotyp1.24332072
63MP0005083_abnormal_biliary_tract1.24188092
64MP0000377_abnormal_hair_follicle1.22551187
65MP0010368_abnormal_lymphatic_system1.20026178
66MP0002132_abnormal_respiratory_system1.19722665
67MP0005164_abnormal_response_to1.19034641
68MP0001958_emphysema1.17607878
69MP0000427_abnormal_hair_cycle1.15639993
70MP0001243_abnormal_dermal_layer1.15023023
71MP0008438_abnormal_cutaneous_collagen1.14738095
72MP0005408_hypopigmentation1.14110939
73MP0005023_abnormal_wound_healing1.12966350
74MP0005395_other_phenotype1.12936412
75MP0005257_abnormal_intraocular_pressure1.12784419
76MP0002160_abnormal_reproductive_system1.12157272
77MP0002909_abnormal_adrenal_gland1.12049778
78MP0004947_skin_inflammation1.10606703
79MP0002249_abnormal_larynx_morphology1.08998229
80MP0002095_abnormal_skin_pigmentation1.07932693
81MP0006054_spinal_hemorrhage1.06373697
82MP0004883_abnormal_blood_vessel1.06252543
83MP0001542_abnormal_bone_strength1.05537153
84MP0009053_abnormal_anal_canal1.05372931
85MP0002233_abnormal_nose_morphology1.05138963
86MP0005085_abnormal_gallbladder_physiolo1.05065318
87MP0001191_abnormal_skin_condition1.02551018
88MP0000613_abnormal_salivary_gland1.02083452
89MP0000465_gastrointestinal_hemorrhage0.99113854
90MP0002282_abnormal_trachea_morphology0.94832408
91MP0010352_gastrointestinal_tract_polyps0.93604914
92MP0000681_abnormal_thyroid_gland0.92342764
93MP0009384_cardiac_valve_regurgitation0.91108950
94MP0009931_abnormal_skin_appearance0.90203222
95MP0004233_abnormal_muscle_weight0.88754439
96MP0003075_altered_response_to0.88559056
97MP0005636_abnormal_mineral_homeostasis0.86923359
98MP0005365_abnormal_bile_salt0.86839679
99MP0009765_abnormal_xenobiotic_induced0.85332021
100MP0001879_abnormal_lymphatic_vessel0.83291521
101MP0000367_abnormal_coat/_hair0.81068279
102MP0000749_muscle_degeneration0.80543681
103MP0002090_abnormal_vision0.80518179
104MP0003303_peritoneal_inflammation0.79459623
105MP0003828_pulmonary_edema0.79254235
106MP0003191_abnormal_cellular_cholesterol0.76988575
107MP0001186_pigmentation_phenotype0.75834688
108MP0009643_abnormal_urine_homeostasis0.75658268
109MP0002075_abnormal_coat/hair_pigmentati0.75542450
110MP0004043_abnormal_pH_regulation0.72900889
111MP0003755_abnormal_palate_morphology0.72336749
112MP0009763_increased_sensitivity_to0.70212023
113MP0005508_abnormal_skeleton_morphology0.69656675
114MP0001664_abnormal_digestion0.69632221
115MP0000733_abnormal_muscle_development0.69335423
116MP0005388_respiratory_system_phenotype0.68049501
117MP0002133_abnormal_respiratory_system0.68049501
118MP0001324_abnormal_eye_pigmentation0.68035265
119MP0000534_abnormal_ureter_morphology0.67098578
120MP0002136_abnormal_kidney_physiology0.66983403
121MP0002277_abnormal_respiratory_mucosa0.66845644
122MP0002896_abnormal_bone_mineralization0.64907255
123MP0005165_increased_susceptibility_to0.63976424
124MP0001873_stomach_inflammation0.63804049
125MP0000049_abnormal_middle_ear0.62754489
126MP0001663_abnormal_digestive_system0.60914600
127MP0003866_abnormal_defecation0.60297916
128MP0000490_abnormal_crypts_of0.59662591
129MP0004185_abnormal_adipocyte_glucose0.59565684
130MP0005319_abnormal_enzyme/_coenzyme0.58959533
131MP0002295_abnormal_pulmonary_circulatio0.58507659
132MP0002177_abnormal_outer_ear0.57725286
133MP0002876_abnormal_thyroid_physiology0.57455493
134MP0003950_abnormal_plasma_membrane0.54024695
135MP0001270_distended_abdomen0.54012519
136MP0000477_abnormal_intestine_morphology0.52493004
137MP0003890_abnormal_embryonic-extraembry0.49740738
138MP0005076_abnormal_cell_differentiation0.48347777
139MP0005310_abnormal_salivary_gland0.46315396
140MP0005389_reproductive_system_phenotype0.46278416
141MP0008873_increased_physiological_sensi0.45756466
142MP0005220_abnormal_exocrine_pancreas0.44953045
143MP0001485_abnormal_pinna_reflex0.44339670
144MP0008872_abnormal_physiological_respon0.42728884
145MP0004858_abnormal_nervous_system0.42492359
146MP0005381_digestive/alimentary_phenotyp0.42155492
147MP0005376_homeostasis/metabolism_phenot0.41388724
148MP0003937_abnormal_limbs/digits/tail_de0.41247739
149MP0002084_abnormal_developmental_patter0.38476180
150MP0002116_abnormal_craniofacial_bone0.37462183

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.87391281
2Chronic bronchitis (HP:0004469)8.47718661
3Bronchiectasis (HP:0002110)7.31650392
4Fragile nails (HP:0001808)7.13924203
5Nasal polyposis (HP:0100582)6.67579673
6Right ventricular cardiomyopathy (HP:0011663)6.38366454
7Plantar hyperkeratosis (HP:0007556)6.17033352
8Abnormality of the nasal mucosa (HP:0000433)5.50996183
9Palmoplantar hyperkeratosis (HP:0000972)5.49533273
10Oral leukoplakia (HP:0002745)5.34808217
11Palmar hyperkeratosis (HP:0010765)5.10913633
12Distal lower limb muscle weakness (HP:0009053)4.87293226
13Onycholysis (HP:0001806)4.83652640
14Milia (HP:0001056)4.44514105
15Bronchitis (HP:0012387)4.31038684
16Recurrent sinusitis (HP:0011108)4.14383790
17Infertility (HP:0000789)4.11740044
18Male infertility (HP:0003251)4.08122637
19Atrophic scars (HP:0001075)4.02665536
20Esophageal atresia (HP:0002032)3.88262188
21Decreased electroretinogram (ERG) amplitude (HP:0000654)3.84212995
22Alopecia of scalp (HP:0002293)3.80701431
23Chronic sinusitis (HP:0011109)3.79858949
24Recurrent otitis media (HP:0000403)3.76138817
25Woolly hair (HP:0002224)3.74369344
26Lip pit (HP:0100267)3.60569048
27Increased connective tissue (HP:0009025)3.54741520
28Abnormality of nail color (HP:0100643)3.27930193
29Occipital encephalocele (HP:0002085)3.26631042
30Erythema (HP:0010783)3.23895015
31Abnormal blistering of the skin (HP:0008066)3.12696496
32Nail dystrophy (HP:0008404)3.10731687
33Atelectasis (HP:0100750)3.07087086
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.98288779
35Thick nail (HP:0001805)2.97509717
36Increased IgE level (HP:0003212)2.96745326
37Muscle fiber inclusion bodies (HP:0100299)2.96020625
38Hyperactive renin-angiotensin system (HP:0000841)2.94870764
39Nemaline bodies (HP:0003798)2.92503018
40Fragile skin (HP:0001030)2.92159172
41Type 1 muscle fiber predominance (HP:0003803)2.88462197
42Chronic otitis media (HP:0000389)2.86707593
43Hypotrichosis (HP:0001006)2.86707160
44Abnormal hemoglobin (HP:0011902)2.84801571
45Pancreatic fibrosis (HP:0100732)2.83334947
46True hermaphroditism (HP:0010459)2.83239075
47Natal tooth (HP:0000695)2.80926753
48Spinal rigidity (HP:0003306)2.77588098
49Distal lower limb amyotrophy (HP:0008944)2.76820428
50Congenital ichthyosiform erythroderma (HP:0007431)2.76106075
51Bronchomalacia (HP:0002780)2.74041134
52Round ear (HP:0100830)2.73743500
53Distal arthrogryposis (HP:0005684)2.68023314
54Cystic liver disease (HP:0006706)2.58721699
55Pterygium (HP:0001059)2.54302580
56Palmoplantar keratoderma (HP:0000982)2.53128525
57Hyporeflexia of lower limbs (HP:0002600)2.51769339
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.45047203
59Osteolytic defects of the hand bones (HP:0009699)2.45047203
60Aplasia involving bones of the extremities (HP:0009825)2.41919517
61Aplasia involving bones of the upper limbs (HP:0009823)2.41919517
62Aplasia of the phalanges of the hand (HP:0009802)2.41919517
63Aplasia cutis congenita (HP:0001057)2.39353398
64Advanced eruption of teeth (HP:0006288)2.37114350
65Exercise-induced muscle cramps (HP:0003710)2.36925788
66Ulnar bowing (HP:0003031)2.36920934
67Humeroradial synostosis (HP:0003041)2.34596258
68Synostosis involving the elbow (HP:0003938)2.34596258
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34199050
70Lower limb amyotrophy (HP:0007210)2.28504668
71Hyperkalemia (HP:0002153)2.25433106
72Scapular winging (HP:0003691)2.25365831
73Stomach cancer (HP:0012126)2.25094476
74Ventricular tachycardia (HP:0004756)2.24523855
75Acanthosis nigricans (HP:0000956)2.23698708
76Molar tooth sign on MRI (HP:0002419)2.21672618
77Abnormality of midbrain morphology (HP:0002418)2.21672618
78Absent phalangeal crease (HP:0006109)2.21071050
79Tubular atrophy (HP:0000092)2.18340772
80Gastrointestinal atresia (HP:0002589)2.18216907
81Curly hair (HP:0002212)2.17082678
82Pancreatic cysts (HP:0001737)2.17010858
83Nephronophthisis (HP:0000090)2.16405530
84Follicular hyperkeratosis (HP:0007502)2.15449427
85Pili torti (HP:0003777)2.15393253
86Premature rupture of membranes (HP:0001788)2.14266972
87Postaxial foot polydactyly (HP:0001830)2.09988039
88Deformed tarsal bones (HP:0008119)2.08911347
89Tubulointerstitial nephritis (HP:0001970)2.06773009
90Abnormality of cells of the erythroid lineage (HP:0012130)2.04280009
91Hypopigmentation of the fundus (HP:0007894)2.03785771
92Ectropion (HP:0000656)2.03196578
93Decreased circulating renin level (HP:0003351)2.02347880
94Myopathic facies (HP:0002058)2.01928388
95Exercise-induced myalgia (HP:0003738)2.00751535
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0042843
97Abnormal respiratory epithelium morphology (HP:0012253)10.9672924
98Abnormal respiratory motile cilium morphology (HP:0005938)10.9672924
99Dynein arm defect of respiratory motile cilia (HP:0012255)10.5939555
100Absent/shortened dynein arms (HP:0200106)10.5939555
101Abnormal respiratory motile cilium physiology (HP:0012261)10.5828451
102Abnormal ciliary motility (HP:0012262)10.2500473
103Conjunctival hamartoma (HP:0100780)1.99737006
104Abnormality of the fovea (HP:0000493)1.99139148
105Sparse scalp hair (HP:0002209)1.98815440
106Bifid scrotum (HP:0000048)1.98214895
107Unilateral renal agenesis (HP:0000122)1.98205848
108Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97555984
109Abnormal number of erythroid precursors (HP:0012131)1.96620966
110Mildly elevated creatine phosphokinase (HP:0008180)1.95772726
111Renal salt wasting (HP:0000127)1.94479530
112Difficulty climbing stairs (HP:0003551)1.94098399
113Protrusio acetabuli (HP:0003179)1.93873985
114Chronic hepatic failure (HP:0100626)1.93689790
115Abnormality of the distal phalanges of the toes (HP:0010182)1.93187150
116Bell-shaped thorax (HP:0001591)1.92873259
117Corneal dystrophy (HP:0001131)1.92866794
118Hyperaldosteronism (HP:0000859)1.92000849
119Corneal erosion (HP:0200020)1.91210193
120Abnormality of chloride homeostasis (HP:0011422)1.91093600
121Hypoplasia of dental enamel (HP:0006297)1.90437240
122Tarsal synostosis (HP:0008368)1.89594484
123Abnormality of skeletal muscle fiber size (HP:0012084)1.87063304
124Muscle fiber splitting (HP:0003555)1.86915508
125Hyponatremia (HP:0002902)1.86231220
126Absent frontal sinuses (HP:0002688)1.85795024
127Popliteal pterygium (HP:0009756)1.85688777
128Ulnar deviation of the wrist (HP:0003049)1.83321465
129Ridged nail (HP:0001807)1.81815886
130Attenuation of retinal blood vessels (HP:0007843)1.78900897
131Interstitial pulmonary disease (HP:0006530)1.78768854
132Bowing of the arm (HP:0006488)1.78242882
133Bowed forearm bones (HP:0003956)1.78242882
134Increased variability in muscle fiber diameter (HP:0003557)1.76137930
135Hyperhidrosis (HP:0000975)1.75025065
136Calcaneovalgus deformity (HP:0001848)1.74972720
137Abnormality of the renal medulla (HP:0100957)1.74970717
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.72957407
139Male pseudohermaphroditism (HP:0000037)1.72657714
140Abnormal sex determination (HP:0012244)1.69431503
141Sex reversal (HP:0012245)1.69431503
142EMG: myopathic abnormalities (HP:0003458)1.68469043
143Abnormality of renin-angiotensin system (HP:0000847)1.68459389
144Abnormal finger flexion creases (HP:0006143)1.68045233
145Short hallux (HP:0010109)1.67043413
146Congenital hepatic fibrosis (HP:0002612)1.66695940
147Mesangial abnormality (HP:0001966)1.66350956
148Short nail (HP:0001799)1.63431218
149Glucose intolerance (HP:0000833)1.61292338
150Nephropathy (HP:0000112)1.59684993
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.59568576
152Anencephaly (HP:0002323)1.58070009
153Vascular calcification (HP:0004934)1.52546487
154Furrowed tongue (HP:0000221)1.51300856
155Asplenia (HP:0001746)1.49991715
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44761402
157Recurrent bronchitis (HP:0002837)1.44571199
158Hypokalemic alkalosis (HP:0001949)1.43474599
159Tubulointerstitial fibrosis (HP:0005576)1.42818421
160Hand muscle atrophy (HP:0009130)1.42522579
161Abnormality of sodium homeostasis (HP:0010931)1.42436615
162Flat acetabular roof (HP:0003180)1.40403038
163Limb-girdle muscle atrophy (HP:0003797)1.40329606
164Spinal cord compression (HP:0002176)1.39897496
165Abnormality of permanent molar morphology (HP:0011071)1.38319908
166Abnormality of the dental root (HP:0006486)1.38319908
167Taurodontia (HP:0000679)1.38319908
168Oculomotor apraxia (HP:0000657)1.37761896
169Hypotension (HP:0002615)1.34554968
170Sclerocornea (HP:0000647)1.34537816
171Tubulointerstitial abnormality (HP:0001969)1.34152027
172Medial flaring of the eyebrow (HP:0010747)1.33090580
173Cardiovascular calcification (HP:0011915)1.31195630
174Congenital primary aphakia (HP:0007707)1.30698536
175Obstructive sleep apnea (HP:0002870)1.26887038
176Abnormality of molar (HP:0011077)1.25737368
177Abnormality of molar morphology (HP:0011070)1.25737368
178Fetal akinesia sequence (HP:0001989)1.25619100
179Gait imbalance (HP:0002141)1.25017947
180Postaxial hand polydactyly (HP:0001162)1.24364734
181Short femoral neck (HP:0100864)1.19958758
182Abnormality of the dental pulp (HP:0006479)1.19898778
183Distal upper limb amyotrophy (HP:0007149)1.17683883
184Upper limb amyotrophy (HP:0009129)1.17683883
185Short thorax (HP:0010306)1.16632130
186Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.15583712
187Median cleft lip (HP:0000161)1.15563396
188Rickets (HP:0002748)1.13212869
189Abnormality of the frontal sinuses (HP:0002687)1.11653926
190Stage 5 chronic kidney disease (HP:0003774)1.11187104
191Nephrogenic diabetes insipidus (HP:0009806)1.10813685
192Cone-rod dystrophy (HP:0000548)1.10394286
193Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.10378967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.58594284
2TTN3.87262052
3MAP3K33.50557824
4MST1R3.46663630
5SMG13.18254533
6MAPKAPK32.59640800
7TRPM72.56442493
8EPHB22.43329091
9ERBB32.34747739
10FER2.30340046
11SIK12.26751012
12EPHA22.25264330
13EEF2K2.23371293
14TRIB32.16042321
15LRRK22.14437233
16TAOK11.98905806
17PIM21.95663406
18SIK31.92056024
19RPS6KB21.90803109
20TTK1.81292229
21MAP2K31.79301197
22RIPK11.75145047
23STK101.72150133
24PIK3CG1.71652234
25MAP3K21.62869249
26TAOK21.54280012
27LATS11.53735816
28ERBB41.53596761
29TESK11.52860736
30MET1.51813331
31PDK21.41244251
32CSK1.40612340
33ICK1.37632248
34FRK1.34977538
35PTK61.33606023
36STK381.27325027
37ERN11.24972621
38OBSCN1.19901154
39CDK61.18317485
40PKN21.17772766
41PTK2B1.13591928
42RPS6KA41.09266484
43PAK41.09232842
44PTK21.06530948
45MAP2K11.05970615
46MARK21.04402551
47LMTK21.04342489
48FGFR21.03695118
49TBK11.03355230
50PDK41.01622680
51PDK31.01622680
52EPHB11.01072955
53DDR21.00874217
54ZAK1.00616630
55NEK61.00058101
56TIE10.97495902
57LIMK10.95976610
58PBK0.94772400
59IRAK30.94348012
60MAP3K110.93943227
61EPHA30.93392389
62NEK10.92636571
63MAP2K20.89668741
64TYRO30.85494959
65DYRK1B0.81068992
66MAP3K120.79516755
67TGFBR20.73545169
68NME10.73311352
69ILK0.71829239
70PAK30.69258889
71MYLK0.69204441
72MAP3K70.68754515
73TYK20.68608909
74NEK90.66871798
75FGFR10.64653835
76CDC42BPA0.63961394
77MAPKAPK50.63944881
78HIPK20.63761293
79PNCK0.63164501
80BMX0.61905730
81TLK10.60470064
82PRKD10.60460794
83BCR0.59706836
84PRKCD0.58587313
85AURKA0.57961981
86CAMKK10.57446354
87STK38L0.56577509
88LATS20.56519277
89CAMK2G0.56449498
90ROCK20.55936982
91SGK30.54104646
92IRAK10.53914589
93PDGFRB0.53803322
94PRKCI0.53625924
95DMPK0.51145787
96PAK20.50214685
97PRKAA20.48504919
98MAPKAPK20.48133633
99CDK80.48120259
100MAP3K10.47527800
101SIK20.46631363
102MATK0.46187540
103RIPK40.45932919
104MAP3K80.45560900
105PDGFRA0.44628994
106ZAP700.43924413
107GRK60.43671401
108ADRBK20.43661188
109ADRBK10.42642890
110TGFBR10.41706356
111ARAF0.41214100
112ERBB20.40970332
113NME20.40898929
114ABL20.40279519
115BCKDK0.39476904
116STK30.37329921
117PHKG20.36842265
118PHKG10.36842265
119BRSK20.36180393
120ROCK10.35891511
121RPS6KA10.34728198
122AKT20.34222427
123PDPK10.33565644
124MARK30.33514357
125MAPK150.33373947
126MAP3K50.33128349
127STK40.31297149
128SRC0.30044932
129PRKG20.29190394
130MELK0.28275381
131PRKD30.27149721
132CDK90.27113116
133EIF2AK10.26712398
134MAP3K90.25315090
135RPS6KA20.24939234
136CDK120.24363511
137PRKCE0.22680242
138STK240.21976722
139KSR20.21926725
140MUSK0.20185679
141MAPK110.19261626
142PAK10.18958913
143PLK10.18537327
144MAP2K40.16841178
145STK160.16438326
146STK390.15488292
147IRAK20.14933438
148PRKD20.14485653
149PRKCA0.14289856
150CHEK20.13892153
151ABL10.13840186
152TSSK60.13193328
153FYN0.12695993

Predicted pathways (KEGG)

RankGene SetZ-score
1* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.93888880
2* Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.59905274
3* Chemical carcinogenesis_Homo sapiens_hsa052044.83251686
4Retinol metabolism_Homo sapiens_hsa008304.09712777
5Glutathione metabolism_Homo sapiens_hsa004803.81961032
6Sulfur metabolism_Homo sapiens_hsa009202.75959569
7* Tyrosine metabolism_Homo sapiens_hsa003502.52907285
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23163172
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11914568
10Fatty acid degradation_Homo sapiens_hsa000712.05774650
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05205934
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96354168
13Gastric acid secretion_Homo sapiens_hsa049711.83295777
14* beta-Alanine metabolism_Homo sapiens_hsa004101.79927620
15ECM-receptor interaction_Homo sapiens_hsa045121.68187328
16Adherens junction_Homo sapiens_hsa045201.54190821
17Tight junction_Homo sapiens_hsa045301.54171875
18* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54082039
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.49274325
20Huntingtons disease_Homo sapiens_hsa050161.46519179
21Salivary secretion_Homo sapiens_hsa049701.46395870
22Fat digestion and absorption_Homo sapiens_hsa049751.38148729
23Arachidonic acid metabolism_Homo sapiens_hsa005901.37126427
24Caffeine metabolism_Homo sapiens_hsa002321.35362396
25Pentose phosphate pathway_Homo sapiens_hsa000301.32878640
26Fructose and mannose metabolism_Homo sapiens_hsa000511.30460286
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27917790
28Sphingolipid metabolism_Homo sapiens_hsa006001.22991186
29Proteoglycans in cancer_Homo sapiens_hsa052051.15625005
30Hippo signaling pathway_Homo sapiens_hsa043901.14888589
31Bladder cancer_Homo sapiens_hsa052191.14513056
32Focal adhesion_Homo sapiens_hsa045101.10824101
33ABC transporters_Homo sapiens_hsa020101.04474636
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02051872
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00902624
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00346012
37Sulfur relay system_Homo sapiens_hsa041220.99312897
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.97839822
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96978253
40TGF-beta signaling pathway_Homo sapiens_hsa043500.95942784
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94587603
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90384913
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85830897
44Dilated cardiomyopathy_Homo sapiens_hsa054140.85466774
45Linoleic acid metabolism_Homo sapiens_hsa005910.83515189
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82841499
47Amoebiasis_Homo sapiens_hsa051460.82305742
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77929569
49Collecting duct acid secretion_Homo sapiens_hsa049660.77083060
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76442305
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74261037
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73356979
53Vitamin digestion and absorption_Homo sapiens_hsa049770.72490012
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72317570
55Hepatitis C_Homo sapiens_hsa051600.71900603
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.70441329
57Thyroid cancer_Homo sapiens_hsa052160.69664256
58Small cell lung cancer_Homo sapiens_hsa052220.69065919
59Melanogenesis_Homo sapiens_hsa049160.67947191
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63108189
61Basal cell carcinoma_Homo sapiens_hsa052170.62747035
62Peroxisome_Homo sapiens_hsa041460.62059046
63Toxoplasmosis_Homo sapiens_hsa051450.60896890
64Vibrio cholerae infection_Homo sapiens_hsa051100.60581144
65Pertussis_Homo sapiens_hsa051330.60137931
66Ovarian steroidogenesis_Homo sapiens_hsa049130.60002872
67Glycerolipid metabolism_Homo sapiens_hsa005610.59621105
68Ribosome_Homo sapiens_hsa030100.58939317
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.58262194
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.57784204
71Phototransduction_Homo sapiens_hsa047440.54907283
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52949141
73Chronic myeloid leukemia_Homo sapiens_hsa052200.52710082
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51663220
75Fatty acid elongation_Homo sapiens_hsa000620.50566023
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45427428
77Lysosome_Homo sapiens_hsa041420.44310783
78Arginine and proline metabolism_Homo sapiens_hsa003300.42442798
79Melanoma_Homo sapiens_hsa052180.42176109
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.41762268
81Axon guidance_Homo sapiens_hsa043600.41551848
82Endometrial cancer_Homo sapiens_hsa052130.41514849
83Rap1 signaling pathway_Homo sapiens_hsa040150.40755063
84* Phenylalanine metabolism_Homo sapiens_hsa003600.40648964
85Galactose metabolism_Homo sapiens_hsa000520.40487760
86* Metabolic pathways_Homo sapiens_hsa011000.39461111
87Fatty acid metabolism_Homo sapiens_hsa012120.39338516
88Starch and sucrose metabolism_Homo sapiens_hsa005000.39285391
89TNF signaling pathway_Homo sapiens_hsa046680.37515137
90N-Glycan biosynthesis_Homo sapiens_hsa005100.37460517
91MicroRNAs in cancer_Homo sapiens_hsa052060.37331023
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37094751
93GnRH signaling pathway_Homo sapiens_hsa049120.37051486
94Folate biosynthesis_Homo sapiens_hsa007900.35664183
95Choline metabolism in cancer_Homo sapiens_hsa052310.35297766
96Pathways in cancer_Homo sapiens_hsa052000.35134050
97PPAR signaling pathway_Homo sapiens_hsa033200.30973892
98Viral myocarditis_Homo sapiens_hsa054160.30346588
99* Histidine metabolism_Homo sapiens_hsa003400.30152331
100Arginine biosynthesis_Homo sapiens_hsa002200.29793523
101Platelet activation_Homo sapiens_hsa046110.29582976
102Glioma_Homo sapiens_hsa052140.29242803
103VEGF signaling pathway_Homo sapiens_hsa043700.28051292
104Estrogen signaling pathway_Homo sapiens_hsa049150.27181590
105Bile secretion_Homo sapiens_hsa049760.26623745
106Mineral absorption_Homo sapiens_hsa049780.26105976
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25928131
108Tryptophan metabolism_Homo sapiens_hsa003800.25657784
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.25607836
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25556755
111Carbon metabolism_Homo sapiens_hsa012000.23939494
112Taste transduction_Homo sapiens_hsa047420.23750872
113Pancreatic secretion_Homo sapiens_hsa049720.23100363
114Acute myeloid leukemia_Homo sapiens_hsa052210.22112148
115Pyruvate metabolism_Homo sapiens_hsa006200.21922184
116Hedgehog signaling pathway_Homo sapiens_hsa043400.21733936
117Insulin signaling pathway_Homo sapiens_hsa049100.21389382
118Prostate cancer_Homo sapiens_hsa052150.21153094
119Insulin resistance_Homo sapiens_hsa049310.20687400
120Ether lipid metabolism_Homo sapiens_hsa005650.20566787
121Malaria_Homo sapiens_hsa051440.20446400
122Circadian rhythm_Homo sapiens_hsa047100.20399914
123Propanoate metabolism_Homo sapiens_hsa006400.19775529
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19572391
125Salmonella infection_Homo sapiens_hsa051320.19460585
126Notch signaling pathway_Homo sapiens_hsa043300.18355566
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.17919738
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17903920
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.17686634
130Renin secretion_Homo sapiens_hsa049240.17515617
131HIF-1 signaling pathway_Homo sapiens_hsa040660.17021273
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.15838482
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15796286
134Thyroid hormone synthesis_Homo sapiens_hsa049180.15558544
135Endocytosis_Homo sapiens_hsa041440.15423640
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14927651
137Apoptosis_Homo sapiens_hsa042100.13660807
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11726990
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.10890567
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07122916
141Pancreatic cancer_Homo sapiens_hsa052120.06547730
142Fatty acid biosynthesis_Homo sapiens_hsa000610.04697443
143Complement and coagulation cascades_Homo sapiens_hsa046100.03383739
144Steroid biosynthesis_Homo sapiens_hsa00100-0.0451468
145Cocaine addiction_Homo sapiens_hsa05030-0.0417829
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0236045
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0099768
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0068278
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0052202

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