ALDH3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.25954711
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.25954711
3L-phenylalanine metabolic process (GO:0006558)6.91073894
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.91073894
5aromatic amino acid family catabolic process (GO:0009074)6.40102315
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11496223
7alpha-linolenic acid metabolic process (GO:0036109)5.90059590
8polyketide metabolic process (GO:0030638)5.85050366
9doxorubicin metabolic process (GO:0044598)5.85050366
10daunorubicin metabolic process (GO:0044597)5.85050366
11tryptophan catabolic process (GO:0006569)5.62005604
12indole-containing compound catabolic process (GO:0042436)5.62005604
13indolalkylamine catabolic process (GO:0046218)5.62005604
14bile acid biosynthetic process (GO:0006699)5.60426515
15kynurenine metabolic process (GO:0070189)5.54193767
16glyoxylate metabolic process (GO:0046487)5.44054106
17aminoglycoside antibiotic metabolic process (GO:0030647)5.34811345
18tryptophan metabolic process (GO:0006568)5.34652009
19high-density lipoprotein particle remodeling (GO:0034375)5.29258291
20cysteine metabolic process (GO:0006534)5.24606575
21sulfur amino acid catabolic process (GO:0000098)5.21142395
22urea metabolic process (GO:0019627)5.18404972
23urea cycle (GO:0000050)5.18404972
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09902842
25negative regulation of fibrinolysis (GO:0051918)5.05317028
26protein carboxylation (GO:0018214)5.03822636
27peptidyl-glutamic acid carboxylation (GO:0017187)5.03822636
28primary alcohol catabolic process (GO:0034310)4.92301512
29bile acid metabolic process (GO:0008206)4.89187887
30epoxygenase P450 pathway (GO:0019373)4.80112283
31regulation of fibrinolysis (GO:0051917)4.79510200
32nitrogen cycle metabolic process (GO:0071941)4.76078733
33serine family amino acid catabolic process (GO:0009071)4.73259868
34reverse cholesterol transport (GO:0043691)4.67887270
35regulation of cholesterol esterification (GO:0010872)4.67092878
36regulation of triglyceride catabolic process (GO:0010896)4.64529879
37aromatic amino acid family metabolic process (GO:0009072)4.63599798
38lysine metabolic process (GO:0006553)4.61979534
39lysine catabolic process (GO:0006554)4.61979534
40amino-acid betaine metabolic process (GO:0006577)4.59722530
41complement activation, alternative pathway (GO:0006957)4.59629792
42regulation of protein activation cascade (GO:2000257)4.58962736
43exogenous drug catabolic process (GO:0042738)4.58474056
44homocysteine metabolic process (GO:0050667)4.56453390
45tyrosine metabolic process (GO:0006570)4.54247310
46protein-lipid complex remodeling (GO:0034368)4.54242823
47macromolecular complex remodeling (GO:0034367)4.54242823
48plasma lipoprotein particle remodeling (GO:0034369)4.54242823
49negative regulation of sterol transport (GO:0032372)4.52203680
50negative regulation of cholesterol transport (GO:0032375)4.52203680
51cellular ketone body metabolic process (GO:0046950)4.50266120
52progesterone metabolic process (GO:0042448)4.49380965
53phospholipid efflux (GO:0033700)4.45145830
54alpha-amino acid catabolic process (GO:1901606)4.38152120
55triglyceride homeostasis (GO:0070328)4.36277849
56acylglycerol homeostasis (GO:0055090)4.36277849
57ethanol metabolic process (GO:0006067)4.31345804
58regulation of complement activation (GO:0030449)4.28142985
59bile acid and bile salt transport (GO:0015721)4.25019513
60plasma lipoprotein particle clearance (GO:0034381)4.22197757
61drug catabolic process (GO:0042737)4.18935070
62cholesterol efflux (GO:0033344)4.14501653
63androgen biosynthetic process (GO:0006702)4.13663698
64cellular amino acid catabolic process (GO:0009063)4.09620476
65cellular glucuronidation (GO:0052695)4.09308132
66glutamate metabolic process (GO:0006536)4.07630024
67ethanol oxidation (GO:0006069)4.06017013
68coenzyme catabolic process (GO:0009109)4.03792829
69indolalkylamine metabolic process (GO:0006586)4.02387155
70glucocorticoid biosynthetic process (GO:0006704)3.99855301
71cellular modified amino acid catabolic process (GO:0042219)3.98548139
72benzene-containing compound metabolic process (GO:0042537)3.96508890
73omega-hydroxylase P450 pathway (GO:0097267)3.91736462
74short-chain fatty acid metabolic process (GO:0046459)3.89512917
75serine family amino acid metabolic process (GO:0009069)3.89430406
76ketone body metabolic process (GO:1902224)3.89330833
77glycine metabolic process (GO:0006544)3.87450205
78plasma lipoprotein particle assembly (GO:0034377)3.87418084
79cellular biogenic amine catabolic process (GO:0042402)3.84468556
80amine catabolic process (GO:0009310)3.84468556
81positive regulation of lipid catabolic process (GO:0050996)3.83339651
82imidazole-containing compound metabolic process (GO:0052803)3.81879109
83dicarboxylic acid biosynthetic process (GO:0043650)3.81682256
84regulation of cholesterol homeostasis (GO:2000188)3.79843999
85low-density lipoprotein particle remodeling (GO:0034374)3.79360089
86desmosome organization (GO:0002934)3.78627984
87drug transmembrane transport (GO:0006855)3.74542949
88phospholipid homeostasis (GO:0055091)3.73259236
89C21-steroid hormone metabolic process (GO:0008207)3.72894319
90positive regulation of triglyceride lipase activity (GO:0061365)3.72106479
91positive regulation of lipoprotein lipase activity (GO:0051006)3.72106479
92aldehyde catabolic process (GO:0046185)3.71386811
93organic acid catabolic process (GO:0016054)3.70044050
94carboxylic acid catabolic process (GO:0046395)3.70044050
95glucuronate metabolic process (GO:0019585)3.67193640
96uronic acid metabolic process (GO:0006063)3.67193640
97acetyl-CoA metabolic process (GO:0006084)3.66404494
98cholesterol homeostasis (GO:0042632)3.66014682
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.64795257
100fibrinolysis (GO:0042730)3.64102205
101serine family amino acid biosynthetic process (GO:0009070)3.63866370
102arginine metabolic process (GO:0006525)3.63552084
103fatty acid beta-oxidation (GO:0006635)3.62569576
104sterol homeostasis (GO:0055092)3.60982603
105very-low-density lipoprotein particle assembly (GO:0034379)3.60379490
106regulation of bile acid biosynthetic process (GO:0070857)3.60208851
107negative regulation of lipase activity (GO:0060192)3.60148920
108fatty acid oxidation (GO:0019395)3.59668442
109heme transport (GO:0015886)3.59611796
110monocarboxylic acid catabolic process (GO:0072329)3.58985661
111low-density lipoprotein particle clearance (GO:0034383)3.55100682
112protein-lipid complex assembly (GO:0065005)3.53603576
113lipid oxidation (GO:0034440)3.52777688
114phenylpropanoid metabolic process (GO:0009698)3.51979447
115drug metabolic process (GO:0017144)3.51720156
116flavonoid metabolic process (GO:0009812)3.51308036
117blood coagulation, intrinsic pathway (GO:0007597)3.51240746
118intestinal cholesterol absorption (GO:0030299)3.50472789
119glycoside metabolic process (GO:0016137)3.50232856
120regulation of cholesterol biosynthetic process (GO:0045540)3.43047081
121negative regulation of protein activation cascade (GO:2000258)3.42904645
122retinal metabolic process (GO:0042574)3.42765893
123hormone catabolic process (GO:0042447)3.29914280
124negative regulation of blood coagulation (GO:0030195)3.25681445
125negative regulation of hemostasis (GO:1900047)3.25681445
126* primary alcohol metabolic process (GO:0034308)3.25673095
127cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.25280100
128glucocorticoid metabolic process (GO:0008211)3.23768648
129carnitine metabolic process (GO:0009437)3.22425192
130response to mercury ion (GO:0046689)3.22357742
131androgen metabolic process (GO:0008209)3.17100141
132gap junction assembly (GO:0016264)3.12168640
133intestinal absorption (GO:0050892)3.10004356
134regulation of cholesterol metabolic process (GO:0090181)3.07148130
135negative regulation of wound healing (GO:0061045)3.06219421
136protein activation cascade (GO:0072376)3.04648177
137negative regulation of coagulation (GO:0050819)3.04584162
138regulation of apoptotic cell clearance (GO:2000425)2.99601156
139biotin metabolic process (GO:0006768)2.99223393
140fat-soluble vitamin biosynthetic process (GO:0042362)2.96696072
141complement activation, classical pathway (GO:0006958)2.95901912
142C21-steroid hormone biosynthetic process (GO:0006700)2.93974178
143regulation of plasminogen activation (GO:0010755)2.93593404
144negative regulation of complement activation (GO:0045916)2.91887922
145response to phenylpropanoid (GO:0080184)2.91593549
146complement activation (GO:0006956)2.91370562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.88381909
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.76256959
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.23303539
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.13359430
5TP63_17297297_ChIP-ChIP_HaCaT_Human5.08654657
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.85700726
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72923098
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.42152593
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86381484
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.42765681
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.63437979
12AR_21909140_ChIP-Seq_LNCAP_Human2.25183403
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03260996
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00011838
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9372307
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89606099
17CLOCK_20551151_ChIP-Seq_293T_Human1.84925006
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.73412814
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64347584
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53671110
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53191582
22GATA1_22025678_ChIP-Seq_K562_Human1.50511915
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44373555
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40880922
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40525422
26* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40010331
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39405369
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37322958
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36579646
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36579646
31* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32066661
32HTT_18923047_ChIP-ChIP_STHdh_Human1.29445734
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26915975
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26246494
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.17124191
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14837540
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13608887
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12290665
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11301575
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.10536451
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09478122
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08939810
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.07137961
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04753823
45* GATA4_25053715_ChIP-Seq_YYC3_Human1.03817714
46TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03435216
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03014403
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02199491
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.01680641
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00409848
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00093070
52RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98993682
53IRF8_22096565_ChIP-ChIP_GC-B_Human0.97194346
54PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96299438
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95550081
56* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92181561
57ESR1_21235772_ChIP-Seq_MCF-7_Human0.91929919
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91754680
59CJUN_26792858_Chip-Seq_BT549_Human0.91019186
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90917820
61RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90571051
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89518080
63NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89518080
64NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89127422
65* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87472099
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85935430
67FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85807436
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83881621
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83520329
70AHR_22903824_ChIP-Seq_MCF-7_Human0.83498289
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82050271
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81489445
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81422975
74TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81028190
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80809777
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79483564
77SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79192226
78GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78063509
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77975128
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77896597
81FOXO3_23340844_ChIP-Seq_DLD1_Human0.77825144
82* EOMES_21245162_ChIP-Seq_HESCs_Human0.77505072
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77364100
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77115734
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75922790
86CHD1_26751641_Chip-Seq_LNCaP_Human0.75735573
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.75686174
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75392251
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75327025
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75318173
91ZNF263_19887448_ChIP-Seq_K562_Human0.73824058
92CDX2_20551321_ChIP-Seq_CACO-2_Human0.72794479
93* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70291485
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69683828
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.68764207
96* SOX2_20726797_ChIP-Seq_SW620_Human0.67290094
97EGR1_19032775_ChIP-ChIP_M12_Human0.65036832
98LXR_22292898_ChIP-Seq_THP-1_Human0.64715051
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63166155
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62014240
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.61536879
102GATA1_19941826_ChIP-Seq_K562_Human0.60591995
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60465490
104* GATA6_25053715_ChIP-Seq_YYC3_Human0.59629036
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59585254
106CEBPB_22108803_ChIP-Seq_LS180_Human0.59441334
107GATA2_19941826_ChIP-Seq_K562_Human0.58079904
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58069533
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57590174
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57349882
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57073046
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55234495
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.55148546
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54808069
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.52735431
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52462516
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52351139
118MYC_19915707_ChIP-ChIP_AK7_Human0.52035486
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51943196
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51572753
121CBP_21632823_ChIP-Seq_H3396_Human0.50466499
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50434939
123BCAT_22108803_ChIP-Seq_LS180_Human0.49969920
124* GATA3_24758297_ChIP-Seq_MCF-7_Human0.49747034
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.49268141
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.48210651
127AR_20517297_ChIP-Seq_VCAP_Human0.47396966
128RACK7_27058665_Chip-Seq_MCF-7_Human0.46697607
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46239164
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.46108220
131* STAT1_17558387_ChIP-Seq_HELA_Human0.45496326
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.45452112
133CDX2_22108803_ChIP-Seq_LS180_Human0.45277841
134* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45240841
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.45167053
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.44812191
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.44812191
138TP63_23658742_ChIP-Seq_EP156T_Human0.44141993
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.43937020
140P53_21459846_ChIP-Seq_SAOS-2_Human0.43895812
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.43183274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27234698
2MP0005360_urolithiasis7.20030521
3MP0005085_abnormal_gallbladder_physiolo6.13933177
4MP0005365_abnormal_bile_salt6.06362338
5MP0008875_abnormal_xenobiotic_pharmacok5.16372770
6MP0003806_abnormal_nucleotide_metabolis3.93244902
7MP0003252_abnormal_bile_duct3.93186268
8MP0010329_abnormal_lipoprotein_level3.44963108
9MP0009840_abnormal_foam_cell3.23702510
10MP0005083_abnormal_biliary_tract3.02165024
11MP0003195_calcinosis2.84630723
12MP0005332_abnormal_amino_acid2.80496897
13MP0001666_abnormal_nutrient_absorption2.72566768
14MP0003941_abnormal_skin_development2.64797576
15MP0003191_abnormal_cellular_cholesterol2.27876692
16MP0004019_abnormal_vitamin_homeostasis2.24635697
17MP0000566_synostosis2.19785566
18MP0002118_abnormal_lipid_homeostasis2.13668493
19MP0002138_abnormal_hepatobiliary_system2.12753113
20MP0000609_abnormal_liver_physiology2.11225977
21MP0003868_abnormal_feces_composition1.83374872
22MP0005319_abnormal_enzyme/_coenzyme1.77549812
23MP0005451_abnormal_body_composition1.58269919
24MP0005584_abnormal_enzyme/coenzyme_acti1.55791935
25MP0009780_abnormal_chondrocyte_physiolo1.53319743
26MP0001764_abnormal_homeostasis1.48689653
27MP0009643_abnormal_urine_homeostasis1.45527569
28MP0003890_abnormal_embryonic-extraembry1.42144913
29MP0002909_abnormal_adrenal_gland1.36639793
30MP0003566_abnormal_cell_adhesion1.27178715
31MP0004272_abnormal_basement_membrane1.26473227
32MP0005501_abnormal_skin_physiology1.26145876
33MP0004185_abnormal_adipocyte_glucose1.21767692
34MP0000604_amyloidosis1.20372628
35MP0003705_abnormal_hypodermis_morpholog1.19920130
36MP0003186_abnormal_redox_activity1.18833995
37MP0009697_abnormal_copulation1.16738962
38MP0005409_darkened_coat_color1.12700896
39MP0000598_abnormal_liver_morphology1.11719109
40MP0002254_reproductive_system_inflammat1.11374783
41MP0004233_abnormal_muscle_weight1.11337512
42MP0002877_abnormal_melanocyte_morpholog1.09538317
43MP0003011_delayed_dark_adaptation1.08913902
44MP0010678_abnormal_skin_adnexa1.08187113
45MP0003656_abnormal_erythrocyte_physiolo1.07706269
46MP0009764_decreased_sensitivity_to1.06290307
47MP0005647_abnormal_sex_gland1.03800657
48MP0005636_abnormal_mineral_homeostasis1.02424837
49MP0002098_abnormal_vibrissa_morphology1.01733317
50MP0010352_gastrointestinal_tract_polyps0.94496235
51MP0001216_abnormal_epidermal_layer0.94296201
52MP0005275_abnormal_skin_tensile0.93781264
53MP0001915_intracranial_hemorrhage0.93567093
54MP0009763_increased_sensitivity_to0.93563834
55MP0009379_abnormal_foot_pigmentation0.93009464
56MP0005408_hypopigmentation0.91317389
57MP0009642_abnormal_blood_homeostasis0.86979196
58MP0002876_abnormal_thyroid_physiology0.86798101
59MP0000537_abnormal_urethra_morphology0.86415630
60MP0008469_abnormal_protein_level0.85288918
61MP0000762_abnormal_tongue_morphology0.84706573
62MP0010368_abnormal_lymphatic_system0.84575505
63MP0002078_abnormal_glucose_homeostasis0.84198642
64MP0001756_abnormal_urination0.83546379
65MP0003329_amyloid_beta_deposits0.82912189
66MP0002060_abnormal_skin_morphology0.79093047
67MP0005257_abnormal_intraocular_pressure0.79021283
68MP0005375_adipose_tissue_phenotype0.78453455
69MP0005220_abnormal_exocrine_pancreas0.78318327
70MP0005084_abnormal_gallbladder_morpholo0.78145536
71MP0009765_abnormal_xenobiotic_induced0.77525896
72MP0003690_abnormal_glial_cell0.77504966
73MP0005076_abnormal_cell_differentiation0.76339193
74MP0002896_abnormal_bone_mineralization0.75619708
75MP0004130_abnormal_muscle_cell0.74280332
76MP0006036_abnormal_mitochondrial_physio0.73425295
77MP0005670_abnormal_white_adipose0.72753035
78MP0000647_abnormal_sebaceous_gland0.72642731
79MP0005023_abnormal_wound_healing0.71995433
80MP0005376_homeostasis/metabolism_phenot0.71573548
81MP0005334_abnormal_fat_pad0.70892950
82MP0005330_cardiomyopathy0.70503574
83MP0002971_abnormal_brown_adipose0.70390816
84MP0001661_extended_life_span0.69690234
85MP0002697_abnormal_eye_size0.69366184
86MP0005535_abnormal_body_temperature0.69259976
87MP0000467_abnormal_esophagus_morphology0.68657049
88MP0004043_abnormal_pH_regulation0.68422517
89MP0000377_abnormal_hair_follicle0.67703172
90MP0010234_abnormal_vibrissa_follicle0.67421028
91MP0002269_muscular_atrophy0.66805737
92MP0005187_abnormal_penis_morphology0.66664037
93MP0004858_abnormal_nervous_system0.64937606
94MP0010030_abnormal_orbit_morphology0.64357698
95MP0002136_abnormal_kidney_physiology0.63761183
96MP0000462_abnormal_digestive_system0.62665296
97MP0008004_abnormal_stomach_pH0.62509526
98MP0005058_abnormal_lysosome_morphology0.62366392
99MP0003879_abnormal_hair_cell0.60211730
100MP0000747_muscle_weakness0.60069336
101MP0003950_abnormal_plasma_membrane0.59789131
102MP0003300_gastrointestinal_ulcer0.59458409
103MP0000383_abnormal_hair_follicle0.58380763
104MP0002837_dystrophic_cardiac_calcinosis0.58163900
105MP0000751_myopathy0.58133913
106MP0005448_abnormal_energy_balance0.57521846
107MP0002928_abnormal_bile_duct0.57447513
108MP0009672_abnormal_birth_weight0.56825952
109MP0000639_abnormal_adrenal_gland0.54700605
110MP0005266_abnormal_metabolism0.54222757
111MP0004782_abnormal_surfactant_physiolog0.53719821
112MP0003638_abnormal_response/metabolism_0.53109360
113MP0005464_abnormal_platelet_physiology0.52089707
114MP0003075_altered_response_to0.48812638
115MP0005666_abnormal_adipose_tissue0.47863831
116MP0009053_abnormal_anal_canal0.47455013
117MP0002168_other_aberrant_phenotype0.47411390
118MP0004264_abnormal_extraembryonic_tissu0.47392483
119MP0008874_decreased_physiological_sensi0.46714879
120MP0005395_other_phenotype0.46292758
121MP0003724_increased_susceptibility_to0.45971070
122MP0003953_abnormal_hormone_level0.45056919
123MP0001765_abnormal_ion_homeostasis0.44383302
124MP0000230_abnormal_systemic_arterial0.43011565
125MP0002796_impaired_skin_barrier0.42403713
126MP0006035_abnormal_mitochondrial_morpho0.42374637
127MP0005166_decreased_susceptibility_to0.41023149
128MP0008873_increased_physiological_sensi0.40692196
129MP0003436_decreased_susceptibility_to0.40189561
130MP0006082_CNS_inflammation0.38868981
131MP0005167_abnormal_blood-brain_barrier0.38099105
132MP0005248_abnormal_Harderian_gland0.37825658
133MP0000249_abnormal_blood_vessel0.33639075
134MP0001845_abnormal_inflammatory_respons0.33248997
135MP0001243_abnormal_dermal_layer0.32637714
136MP0002822_catalepsy0.32211838
137MP0002090_abnormal_vision0.31891534
138MP0009384_cardiac_valve_regurgitation0.31166847
139MP0001881_abnormal_mammary_gland0.30886593
140MP0008872_abnormal_physiological_respon0.29896449
141MP0003453_abnormal_keratinocyte_physiol0.29715613
142MP0004883_abnormal_blood_vessel0.28926025
143MP0000579_abnormal_nail_morphology0.28725391
144MP0001944_abnormal_pancreas_morphology0.28621410

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.05716890
2Intrahepatic cholestasis (HP:0001406)6.98339261
3Deep venous thrombosis (HP:0002625)6.92485075
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28298187
5Xanthomatosis (HP:0000991)6.17611408
6Hypobetalipoproteinemia (HP:0003563)6.04456686
7Prolonged partial thromboplastin time (HP:0003645)5.89797014
8Hyperlipoproteinemia (HP:0010980)5.31556510
9Hyperammonemia (HP:0001987)4.52849057
10Hypolipoproteinemia (HP:0010981)4.51390944
11Complement deficiency (HP:0004431)4.49923238
12Epidermoid cyst (HP:0200040)4.41318867
13Joint hemorrhage (HP:0005261)4.40177885
14Ketosis (HP:0001946)4.39115445
15Hyperglycinemia (HP:0002154)4.23529682
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21515881
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16623735
18Abnormality of the common coagulation pathway (HP:0010990)4.15277931
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.10689558
20Fat malabsorption (HP:0002630)4.07175552
21Hypoglycemic coma (HP:0001325)4.05938119
22Hyperglycinuria (HP:0003108)4.02351261
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97446753
24Abnormality of glycine metabolism (HP:0010895)3.97100287
25Abnormality of serine family amino acid metabolism (HP:0010894)3.97100287
26Hypoalphalipoproteinemia (HP:0003233)3.94293898
27Abnormality of methionine metabolism (HP:0010901)3.88882495
28Conjugated hyperbilirubinemia (HP:0002908)3.84868374
29Abnormality of the intrinsic pathway (HP:0010989)3.61849426
30Abnormality of fatty-acid metabolism (HP:0004359)3.54982857
31Hypercholesterolemia (HP:0003124)3.53814482
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47186018
33Ketoacidosis (HP:0001993)3.38436957
34Hyperbilirubinemia (HP:0002904)3.26992387
35Abnormality of pyrimidine metabolism (HP:0004353)3.25651940
36Abnormality of complement system (HP:0005339)3.22422245
37Right ventricular cardiomyopathy (HP:0011663)3.20376126
38Abnormality of nucleobase metabolism (HP:0010932)3.11040616
39Abnormality of purine metabolism (HP:0004352)3.03734954
40Delayed CNS myelination (HP:0002188)3.00664116
41Steatorrhea (HP:0002570)2.98397137
42Renal salt wasting (HP:0000127)2.97453062
43Hepatocellular carcinoma (HP:0001402)2.89795198
44Nephritis (HP:0000123)2.88886366
45Gout (HP:0001997)2.85011193
46Metabolic acidosis (HP:0001942)2.84220272
47Myocardial infarction (HP:0001658)2.82882770
48Skin nodule (HP:0200036)2.82188215
49Abnormality of serum amino acid levels (HP:0003112)2.79439873
50Vascular calcification (HP:0004934)2.78738760
51Reduced antithrombin III activity (HP:0001976)2.74626442
52Hypoglycemic seizures (HP:0002173)2.73337671
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66160598
54Dicarboxylic aciduria (HP:0003215)2.66160598
55Spastic diplegia (HP:0001264)2.53870156
56Systemic lupus erythematosus (HP:0002725)2.50950771
57Cardiovascular calcification (HP:0011915)2.50852287
58Lethargy (HP:0001254)2.50828331
59Flat acetabular roof (HP:0003180)2.50825367
60Malnutrition (HP:0004395)2.48095015
61Spontaneous abortion (HP:0005268)2.45525999
62Acanthocytosis (HP:0001927)2.45070612
63Bifid scrotum (HP:0000048)2.43259077
64Mitral stenosis (HP:0001718)2.42854809
65Hypochromic microcytic anemia (HP:0004840)2.41687432
66Abnormal gallbladder morphology (HP:0012437)2.40938276
67Generalized aminoaciduria (HP:0002909)2.40138300
68Irritability (HP:0000737)2.37854616
69Esophageal varix (HP:0002040)2.34343626
70Hyperaldosteronism (HP:0000859)2.33361622
71Glomerulonephritis (HP:0000099)2.30980127
72Late onset (HP:0003584)2.30782061
73Cholelithiasis (HP:0001081)2.30227191
74Abnormal sex determination (HP:0012244)2.28801853
75Sex reversal (HP:0012245)2.28801853
76Sensorimotor neuropathy (HP:0007141)2.27863240
77Osteomalacia (HP:0002749)2.27394272
78Cholecystitis (HP:0001082)2.27387559
79Abnormal gallbladder physiology (HP:0012438)2.27387559
80Abnormality of carpal bone ossification (HP:0006257)2.25860490
81Pancreatitis (HP:0001733)2.20306633
82Hyperinsulinemic hypoglycemia (HP:0000825)2.19347178
83Abnormality of proline metabolism (HP:0010907)2.17948931
84Hydroxyprolinuria (HP:0003080)2.17948931
85Neonatal onset (HP:0003623)2.16370285
86Enlarged kidneys (HP:0000105)2.15048703
87Alkalosis (HP:0001948)2.14722656
88Amyloidosis (HP:0011034)2.14505059
89Cerebral edema (HP:0002181)2.12708736
90Brushfield spots (HP:0001088)2.12567811
91Abnormal tarsal ossification (HP:0008369)2.12268148
92Neurofibrillary tangles (HP:0002185)2.10868641
93Rickets (HP:0002748)2.10026565
94Vomiting (HP:0002013)2.09442292
95Back pain (HP:0003418)2.08360150
96Menorrhagia (HP:0000132)2.06590883
97Proximal tubulopathy (HP:0000114)2.03638446
98Recurrent gram-negative bacterial infections (HP:0005420)2.03605417
99Renal cortical cysts (HP:0000803)2.02071653
100Hemorrhage of the eye (HP:0011885)1.99911879
101Opisthotonus (HP:0002179)1.99731509
102Abnormality of the gallbladder (HP:0005264)1.98239403
103Abnormality of urine glucose concentration (HP:0011016)1.97532055
104Glycosuria (HP:0003076)1.97532055
105Gingival bleeding (HP:0000225)1.97314683
106Increased purine levels (HP:0004368)1.97220353
107Hyperuricemia (HP:0002149)1.97220353
108Hyperactive renin-angiotensin system (HP:0000841)1.96614644
109Abnormality of the Achilles tendon (HP:0005109)1.94178371
110Abnormal enzyme/coenzyme activity (HP:0012379)1.93012954
111Abnormality of the gastric mucosa (HP:0004295)1.91136941
112Short nail (HP:0001799)1.91112358
113Abnormal cartilage morphology (HP:0002763)1.91070601
114Abnormality of vitamin metabolism (HP:0100508)1.90078170
115Neonatal death (HP:0003811)1.88933817
116Symptomatic seizures (HP:0011145)1.87339907
117Abnormality of glycolysis (HP:0004366)1.86001728
118Advanced eruption of teeth (HP:0006288)1.85217221
119Hyperglycemia (HP:0003074)1.84625762
120Increased serum pyruvate (HP:0003542)1.84329914
121Abnormality of transition element cation homeostasis (HP:0011030)1.83177579
122Thrombophlebitis (HP:0004418)1.82292575
123Hypophosphatemic rickets (HP:0004912)1.80644519
124Cerebral inclusion bodies (HP:0100314)1.79879531
125Palmoplantar hyperkeratosis (HP:0000972)1.79386192
126Abnormality of secondary sexual hair (HP:0009888)1.78526947
127Abnormality of the axillary hair (HP:0100134)1.78526947
128Acanthosis nigricans (HP:0000956)1.77399583
129Atrioventricular block (HP:0001678)1.75917205
130Aplasia involving bones of the extremities (HP:0009825)1.74026502
131Aplasia involving bones of the upper limbs (HP:0009823)1.74026502
132Aplasia of the phalanges of the hand (HP:0009802)1.74026502
133Palmar hyperkeratosis (HP:0010765)1.71309813
134Tetraparesis (HP:0002273)1.69768810
135Exercise-induced myalgia (HP:0003738)1.66631948
136Abnormal ossification of hand bones (HP:0005921)1.65947110
137Absent eyelashes (HP:0000561)1.65843457
138Bronchomalacia (HP:0002780)1.64979413
139Abnormal hand bone ossification (HP:0010660)1.61874621
140Elevated alkaline phosphatase (HP:0003155)1.61168736
141Plantar hyperkeratosis (HP:0007556)1.60934153
142Vertebral arch anomaly (HP:0008438)1.59288631
143Pterygium (HP:0001059)1.57660623
144Abnormality of the dental root (HP:0006486)1.56415588
145Taurodontia (HP:0000679)1.56415588
146Abnormality of permanent molar morphology (HP:0011071)1.56415588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.21777324
2SIK14.29099389
3ERN14.12631176
4FGFR43.86276632
5EPHA23.48947303
6TAOK32.99992072
7INSRR2.97325184
8LATS22.52489774
9PKN22.22267407
10MST1R2.11862613
11ERBB42.09791717
12LMTK22.08946740
13PBK2.07333229
14FRK2.06610771
15EEF2K2.06559100
16TRIB32.03418809
17MAP2K41.93303469
18PTK61.84718314
19PIK3CG1.74737553
20LATS11.70175731
21NEK11.66704760
22FLT31.60570391
23FGFR21.59933842
24EPHB11.58758741
25TYK21.49153194
26DAPK21.44270018
27SCYL21.44231371
28PAK41.31603577
29MAPK111.28732656
30MAP3K121.25153811
31TESK11.24299811
32MAP3K91.23455574
33PRPF4B1.21530579
34MET1.21505244
35NEK91.15959808
36JAK21.15891462
37MAP3K71.12514302
38JAK11.12193578
39DDR21.10995844
40EPHB21.09481341
41MAPK151.08307342
42ABL21.06732295
43RIPK11.05524579
44MAP2K31.05419143
45PRKD31.04041862
46PRKAA21.03610788
47WNK41.01491801
48MAP3K30.99860021
49TBK10.99598302
50MAP3K100.99352362
51TTK0.98052815
52ERBB30.97896644
53MAPKAPK30.95831713
54MAP3K20.95229592
55BCR0.94268806
56KDR0.93919428
57PTK20.93334617
58FGFR10.93095601
59MAP3K60.91662539
60MAP3K140.89756821
61CAMK1D0.86765616
62GRK60.84171588
63CSK0.83363196
64OBSCN0.83344245
65GSK3A0.83061393
66TGFBR20.81781228
67SGK30.80472852
68OXSR10.79356912
69EPHA30.79145753
70SMG10.79076970
71STK240.78443673
72PRKCZ0.78356111
73BRSK20.77776817
74STK380.77257273
75TIE10.76277883
76CDK120.75983916
77AKT20.75959127
78ERBB20.74575749
79IRAK30.74428095
80ARAF0.73132091
81STK38L0.72541760
82NTRK10.72533260
83PINK10.70402750
84STK390.70325018
85PDPK10.69762121
86CDK60.69525839
87MAPK40.68725453
88RET0.67683502
89TTN0.67386311
90DYRK1B0.66268662
91PRKACG0.66081888
92MST40.65842841
93FER0.64823419
94SGK2230.64713526
95SGK4940.64713526
96CAMK2G0.61414147
97PIK3CA0.60435296
98PRKAA10.60365555
99LIMK10.60337027
100YES10.59598799
101MAP2K10.58396167
102FGFR30.58245509
103EIF2AK10.58076209
104PAK30.57934874
105PRKCQ0.55216774
106EIF2AK30.55035295
107CDK90.54934552
108DMPK0.54882105
109SGK20.54271000
110MAP2K60.54262705
111MAP2K20.54117702
112CAMK1G0.53397175
113MAPK120.53231665
114PDGFRA0.53186420
115CSNK1G10.51333547
116AKT30.51278409
117MELK0.51038311
118MAP3K10.50396610
119PDK30.48481979
120PDK40.48481979
121EPHA40.47560568
122PHKG10.47394778
123PHKG20.47394778
124PIM20.46702691
125TAOK20.46676805
126CSF1R0.45570143
127KSR20.45471112
128MAP3K110.45092092
129PDK10.44545136
130IGF1R0.43302431
131NLK0.42314678
132LRRK20.41476891
133NEK60.41160579
134MAPK100.40858541
135CDK70.40669738
136ITK0.39554159
137PDGFRB0.39349246
138CSNK1G20.38890982
139IKBKE0.38591653
140MAPK70.38122220
141ACVR1B0.38034739
142STK30.37848143
143ICK0.37780642
144BMX0.37164556
145EGFR0.35469384
146MAP3K130.34382275
147CSNK1A1L0.34260557
148MTOR0.33941000
149PRKCH0.32206977
150GRK10.32098272
151MYLK0.31646952
152PDK20.30879307
153CSNK1G30.30340241

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24998470
2Nitrogen metabolism_Homo sapiens_hsa009103.49317915
3* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28681210
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17189238
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.99960125
6Arginine biosynthesis_Homo sapiens_hsa002202.87012472
7* Tryptophan metabolism_Homo sapiens_hsa003802.62634618
8* Fatty acid degradation_Homo sapiens_hsa000712.59223986
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56207741
10Complement and coagulation cascades_Homo sapiens_hsa046102.46554045
11* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46399340
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36879245
13Butanoate metabolism_Homo sapiens_hsa006502.33940552
14* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19842533
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17423443
16Peroxisome_Homo sapiens_hsa041462.15239169
17Propanoate metabolism_Homo sapiens_hsa006402.09243530
18Fatty acid metabolism_Homo sapiens_hsa012122.01394698
19PPAR signaling pathway_Homo sapiens_hsa033201.98501911
20Chemical carcinogenesis_Homo sapiens_hsa052041.93117588
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92466303
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.84010865
23* Histidine metabolism_Homo sapiens_hsa003401.78189436
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75935494
25Caffeine metabolism_Homo sapiens_hsa002321.72444957
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.65644677
27Retinol metabolism_Homo sapiens_hsa008301.65305723
28* beta-Alanine metabolism_Homo sapiens_hsa004101.64111267
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63378039
30Sulfur metabolism_Homo sapiens_hsa009201.61801569
31Staphylococcus aureus infection_Homo sapiens_hsa051501.60616739
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60264730
33Bile secretion_Homo sapiens_hsa049761.57962270
34Fatty acid elongation_Homo sapiens_hsa000621.49541925
35Phenylalanine metabolism_Homo sapiens_hsa003601.49131957
36Selenocompound metabolism_Homo sapiens_hsa004501.48687848
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47879031
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36569119
39* Pyruvate metabolism_Homo sapiens_hsa006201.35344305
40Tyrosine metabolism_Homo sapiens_hsa003501.32898366
41Fat digestion and absorption_Homo sapiens_hsa049751.30325435
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27565711
43ABC transporters_Homo sapiens_hsa020101.25398485
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.21680915
45Steroid biosynthesis_Homo sapiens_hsa001001.19218444
46Folate biosynthesis_Homo sapiens_hsa007901.17430002
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.15270291
48Carbon metabolism_Homo sapiens_hsa012001.12263523
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05898202
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02857980
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.02517681
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01080597
53Vitamin digestion and absorption_Homo sapiens_hsa049770.97807472
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87345303
55* Arginine and proline metabolism_Homo sapiens_hsa003300.86712326
56Sulfur relay system_Homo sapiens_hsa041220.85822916
57* Lysine degradation_Homo sapiens_hsa003100.77100119
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73642282
59Glutathione metabolism_Homo sapiens_hsa004800.72020288
60* Glycerolipid metabolism_Homo sapiens_hsa005610.69249101
61Vitamin B6 metabolism_Homo sapiens_hsa007500.66331237
62* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64219264
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61803243
64Fatty acid biosynthesis_Homo sapiens_hsa000610.60212348
65Sphingolipid metabolism_Homo sapiens_hsa006000.56364966
66Pentose phosphate pathway_Homo sapiens_hsa000300.50993105
67Other glycan degradation_Homo sapiens_hsa005110.48296447
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45249822
69One carbon pool by folate_Homo sapiens_hsa006700.44063480
70* Metabolic pathways_Homo sapiens_hsa011000.42931336
71Adherens junction_Homo sapiens_hsa045200.42732787
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36945339
73Insulin resistance_Homo sapiens_hsa049310.33059482
74Tight junction_Homo sapiens_hsa045300.30806202
75Galactose metabolism_Homo sapiens_hsa000520.30253046
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.29277606
77Fructose and mannose metabolism_Homo sapiens_hsa000510.26895645
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24627720
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24353098
80Linoleic acid metabolism_Homo sapiens_hsa005910.22923028
81Prion diseases_Homo sapiens_hsa050200.22764553
82Circadian rhythm_Homo sapiens_hsa047100.20004259
83ECM-receptor interaction_Homo sapiens_hsa045120.19465282
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.18330569
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17790667
86Thyroid cancer_Homo sapiens_hsa052160.17233257
87Glucagon signaling pathway_Homo sapiens_hsa049220.11378427
88N-Glycan biosynthesis_Homo sapiens_hsa005100.10975977
89Ether lipid metabolism_Homo sapiens_hsa005650.08839587
90Pertussis_Homo sapiens_hsa051330.06247662
91AMPK signaling pathway_Homo sapiens_hsa041520.05680144
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.00830170
93Amoebiasis_Homo sapiens_hsa05146-0.1827052
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1753160
95African trypanosomiasis_Homo sapiens_hsa05143-0.1593541
96Type II diabetes mellitus_Homo sapiens_hsa04930-0.1568116
97Protein digestion and absorption_Homo sapiens_hsa04974-0.1547348
98Regulation of autophagy_Homo sapiens_hsa04140-0.1527887
99Hepatitis C_Homo sapiens_hsa05160-0.1194995
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1084793
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1042666
102Mineral absorption_Homo sapiens_hsa04978-0.1008038
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0830789
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0797574
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0787760
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0772215
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0705821
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0681442
109Lysosome_Homo sapiens_hsa04142-0.0677899
110Insulin signaling pathway_Homo sapiens_hsa04910-0.0639457
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0359886
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0072134

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