ALDH3B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.78087713
2regulation of water loss via skin (GO:0033561)9.08172614
3hemidesmosome assembly (GO:0031581)7.43751805
4keratinocyte differentiation (GO:0030216)7.40622840
5sphingoid metabolic process (GO:0046519)6.86598829
6fatty acid elongation (GO:0030497)6.57400239
7keratinocyte proliferation (GO:0043616)6.49186814
8intermediate filament organization (GO:0045109)6.44722459
9peptide cross-linking (GO:0018149)6.44307268
10sphingosine metabolic process (GO:0006670)6.25696139
11multicellular organismal water homeostasis (GO:0050891)6.15897320
12intestinal epithelial cell development (GO:0060576)6.09758013
13positive regulation of keratinocyte differentiation (GO:0045618)6.09526142
14epidermal cell differentiation (GO:0009913)5.72286841
15diol metabolic process (GO:0034311)5.70922141
16long-chain fatty acid biosynthetic process (GO:0042759)5.62472794
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.60833339
18epidermis development (GO:0008544)5.54440057
19keratinocyte development (GO:0003334)5.52678528
20interferon-gamma secretion (GO:0072643)5.42983272
21long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.14433863
22water homeostasis (GO:0030104)5.11485739
23ear development (GO:0043583)5.08804176
24regulation of phospholipase A2 activity (GO:0032429)4.95940044
25regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.71333764
26regulation of ruffle assembly (GO:1900027)4.53887104
27fatty-acyl-CoA metabolic process (GO:0035337)4.51091806
28epithelial cell differentiation involved in prostate gland development (GO:0060742)4.41608809
29mammary gland epithelial cell differentiation (GO:0060644)4.38182835
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.36975410
31COPI coating of Golgi vesicle (GO:0048205)4.35850933
32Golgi transport vesicle coating (GO:0048200)4.35850933
33epithelial cell maturation (GO:0002070)4.31105999
34regulation of keratinocyte differentiation (GO:0045616)4.28068717
35glucosamine-containing compound catabolic process (GO:1901072)4.17535064
36viral transcription (GO:0019083)4.17070479
37detection of bacterium (GO:0016045)4.16780801
38ectoderm development (GO:0007398)4.15487739
39fatty-acyl-CoA biosynthetic process (GO:0046949)4.06312148
40phosphatidylinositol acyl-chain remodeling (GO:0036149)4.03160976
41intermediate filament cytoskeleton organization (GO:0045104)4.01208235
42skin morphogenesis (GO:0043589)3.96992028
43uterus development (GO:0060065)3.93210146
44intermediate filament-based process (GO:0045103)3.90255603
45translational termination (GO:0006415)3.89914591
46maternal placenta development (GO:0001893)3.89505704
47regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.77029206
48endothelial cell chemotaxis (GO:0035767)3.69612475
49negative regulation of cell size (GO:0045792)3.67204216
50gap junction assembly (GO:0016264)3.58303991
51phosphatidylserine acyl-chain remodeling (GO:0036150)3.56242142
52epithelial cell-cell adhesion (GO:0090136)3.52905776
53prostanoid biosynthetic process (GO:0046457)3.52686587
54prostaglandin biosynthetic process (GO:0001516)3.52686587
55ribosomal small subunit biogenesis (GO:0042274)3.52422008
56proline biosynthetic process (GO:0006561)3.51520653
57detection of other organism (GO:0098543)3.50013931
58cell wall macromolecule metabolic process (GO:0044036)3.44515597
59cell wall macromolecule catabolic process (GO:0016998)3.44515597
60virion attachment to host cell (GO:0019062)3.43856736
61adhesion of symbiont to host cell (GO:0044650)3.43856736
62polarized epithelial cell differentiation (GO:0030859)3.40593270
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.37853732
64planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37797900
65branching involved in mammary gland duct morphogenesis (GO:0060444)3.34304266
66negative regulation of cell fate commitment (GO:0010454)3.32181764
67negative regulation of kidney development (GO:0090185)3.32068974
68negative regulation of acute inflammatory response (GO:0002674)3.31697294
69amyloid precursor protein catabolic process (GO:0042987)3.26178943
70acyl-CoA biosynthetic process (GO:0071616)3.25115732
71thioester biosynthetic process (GO:0035384)3.25115732
72positive regulation of interleukin-8 secretion (GO:2000484)3.22231173
73negative regulation of keratinocyte proliferation (GO:0010839)3.22206786
74cyclooxygenase pathway (GO:0019371)3.20799309
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.18702845
76cellular response to antibiotic (GO:0071236)3.15084978
77regulation of establishment or maintenance of cell polarity (GO:0032878)3.14985198
78vagina development (GO:0060068)3.12515035
79regulation of cell proliferation involved in kidney development (GO:1901722)3.11493908
80regulation of sequestering of triglyceride (GO:0010889)3.11403026
81semaphorin-plexin signaling pathway (GO:0071526)3.10068744
82response to food (GO:0032094)3.10057842
83establishment of planar polarity (GO:0001736)3.09632637
84establishment of tissue polarity (GO:0007164)3.09632637
85viral life cycle (GO:0019058)3.07933459
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.06929465
87positive regulation of Cdc42 GTPase activity (GO:0043089)3.06606480
88phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.05792734
89surfactant homeostasis (GO:0043129)3.02505379
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02489758
91regulation of histone H3-K27 methylation (GO:0061085)3.01775311
92linoleic acid metabolic process (GO:0043651)3.00917924
93protein targeting to ER (GO:0045047)3.00887930
94negative regulation of axon extension involved in axon guidance (GO:0048843)3.00121988
95translational elongation (GO:0006414)2.98940585
96cotranslational protein targeting to membrane (GO:0006613)2.98526687
97cellular protein complex disassembly (GO:0043624)2.96863600
98regulation of fatty acid beta-oxidation (GO:0031998)2.96739911
99prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.96105356
100response to phenylpropanoid (GO:0080184)2.95748353
101regulation of interleukin-13 production (GO:0032656)2.95013082
102purine nucleotide transport (GO:0015865)2.94966863
103regulation of chemokine secretion (GO:0090196)2.94916377
104regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.93597161
105norepinephrine metabolic process (GO:0042415)2.93308346
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93267238
107retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92877788
108regulation of epidermal cell differentiation (GO:0045604)2.92691234
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.92455210
110face development (GO:0060324)2.91824046
111positive regulation of vesicle fusion (GO:0031340)2.91458684
112proline metabolic process (GO:0006560)2.90437062
113hair follicle morphogenesis (GO:0031069)2.89761718
114phosphatidylcholine acyl-chain remodeling (GO:0036151)2.88950557
115regulation of clathrin-mediated endocytosis (GO:2000369)2.88549022
116regulation of autophagic vacuole assembly (GO:2000785)2.87934570
117skin development (GO:0043588)2.87845515
118prostaglandin metabolic process (GO:0006693)2.87150730
119prostanoid metabolic process (GO:0006692)2.87150730
120columnar/cuboidal epithelial cell development (GO:0002066)2.85948242
121negative regulation of stress fiber assembly (GO:0051497)2.84166926
122negative regulation of interferon-gamma production (GO:0032689)2.83377295
123eyelid development in camera-type eye (GO:0061029)2.81708142
124protein localization to endoplasmic reticulum (GO:0070972)2.81402675
125gland morphogenesis (GO:0022612)2.80887528
126triglyceride biosynthetic process (GO:0019432)2.80679122
127cardiac right ventricle morphogenesis (GO:0003215)2.80645169
128white fat cell differentiation (GO:0050872)2.80034512
129regulation of hypersensitivity (GO:0002883)2.79107458
130biotin metabolic process (GO:0006768)2.78497648
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78091325
132prostate gland epithelium morphogenesis (GO:0060740)2.77751647
133cardiolipin metabolic process (GO:0032048)2.77704485
134cell differentiation involved in embryonic placenta development (GO:0060706)2.77483185
135peptidyl-tyrosine autophosphorylation (GO:0038083)2.77012817
136neutral lipid biosynthetic process (GO:0046460)2.76663487
137acylglycerol biosynthetic process (GO:0046463)2.76663487
138amyloid precursor protein metabolic process (GO:0042982)2.75846977
139response to water (GO:0009415)2.74416972
140adhesion of symbiont to host (GO:0044406)2.73886751
141brown fat cell differentiation (GO:0050873)2.73117422
142positive regulation of epidermis development (GO:0045684)2.71986257
143ceramide biosynthetic process (GO:0046513)2.71319637
144negative regulation of fatty acid transport (GO:2000192)2.70441806
145very long-chain fatty acid metabolic process (GO:0000038)2.69923448
146regulation of Cdc42 GTPase activity (GO:0043088)2.69471743
147positive regulation of epidermal cell differentiation (GO:0045606)2.69428664
148atrioventricular valve morphogenesis (GO:0003181)2.68635634
149regulation of interleukin-8 secretion (GO:2000482)2.68329068
150regulation of epidermis development (GO:0045682)2.67781298
151negative regulation of cell fate specification (GO:0009996)2.67780696
152low-density lipoprotein particle clearance (GO:0034383)2.67471949
153glandular epithelial cell differentiation (GO:0002067)2.67392083
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67245749
155epithelium development (GO:0060429)2.67142559
156negative regulation of lipase activity (GO:0060192)2.65927755
157lipoxygenase pathway (GO:0019372)2.62932755
158desmosome organization (GO:0002934)14.2336010
159molting cycle (GO:0042303)11.0718502
160hair cycle (GO:0042633)11.0718502
161keratinization (GO:0031424)10.8123670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.27000199
2* ESR1_20079471_ChIP-ChIP_T-47D_Human5.09563238
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.28438252
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13525215
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.97775255
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91932943
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55176445
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.41608991
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25221372
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14144982
11ZNF263_19887448_ChIP-Seq_K562_Human2.13526134
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02421436
13TP63_17297297_ChIP-ChIP_HaCaT_Human15.1873098
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.77939370
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.75607489
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.71977184
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70214017
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70214017
19ELF5_23300383_ChIP-Seq_T47D_Human1.64030491
20CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.61583340
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.57021356
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.56335817
23SMC4_20622854_ChIP-Seq_HELA_Human1.53723749
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52904222
25CREB1_26743006_Chip-Seq_LNCaP_Human1.50434572
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48718155
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47620513
28P68_20966046_ChIP-Seq_HELA_Human1.37549613
29TP63_22573176_ChIP-Seq_HFKS_Human1.37416782
30BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36682412
31TCF7_22412390_ChIP-Seq_EML_Mouse1.36572975
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.36560861
33SOX2_20726797_ChIP-Seq_SW620_Human1.34553854
34CHD1_26751641_Chip-Seq_LNCaP_Human1.32562019
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31407882
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27649500
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26941388
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26920341
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26016456
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25939340
41KDM2B_26808549_Chip-Seq_DND41_Human1.25703100
42TP63_23658742_ChIP-Seq_EP156T_Human1.24385731
43KLF5_25053715_ChIP-Seq_YYC3_Human1.23062716
44KDM2B_26808549_Chip-Seq_K562_Human1.22966192
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22757638
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21911267
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21618667
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20871167
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20445553
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19120983
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19021951
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13655042
53* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13307398
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12900945
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12619196
56CJUN_26792858_Chip-Seq_BT549_Human1.11411712
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11308344
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11178129
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10204731
60TP53_18474530_ChIP-ChIP_U2OS_Human1.08747853
61* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08645245
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.06038604
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05691489
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05381479
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.05061619
66VDR_22108803_ChIP-Seq_LS180_Human1.03508196
67BCAT_22108803_ChIP-Seq_LS180_Human1.02928543
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.02832629
69VDR_21846776_ChIP-Seq_THP-1_Human1.02202672
70* AHR_22903824_ChIP-Seq_MCF-7_Human1.00678397
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.00195515
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00181913
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99047523
74GATA4_25053715_ChIP-Seq_YYC3_Human0.98990891
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98813906
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98432433
77KDM5A_27292631_Chip-Seq_BREAST_Human0.98377834
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98341548
79PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98323880
80EED_16625203_ChIP-ChIP_MESCs_Mouse0.97134796
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.96981882
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96497304
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96247174
84CEBPB_22108803_ChIP-Seq_LS180_Human0.95739660
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95364324
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94929437
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94011804
88CTCF_27219007_Chip-Seq_Bcells_Human0.93794617
89ATF3_27146783_Chip-Seq_COLON_Human0.93332098
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93238278
91GATA3_24758297_ChIP-Seq_MCF-7_Human0.93091249
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93016546
93CTCF_20526341_ChIP-Seq_ESCs_Human0.92005535
94* RACK7_27058665_Chip-Seq_MCF-7_Human0.91578130
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90559781
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89626886
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89128794
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88991514
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.88796009
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88663150
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88368797
102RARB_24833708_ChIP-Seq_LIVER_Mouse0.88277541
103* RXR_22108803_ChIP-Seq_LS180_Human0.88257147
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.87740887
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87424993
106* MYC_22102868_ChIP-Seq_BL_Human0.86747489
107E2F1_20622854_ChIP-Seq_HELA_Human0.85572574
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85338381
109AR_21572438_ChIP-Seq_LNCaP_Human0.85310674
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.84986834
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84426990
112AR_21909140_ChIP-Seq_LNCAP_Human0.84031829
113* ARNT_22903824_ChIP-Seq_MCF-7_Human0.83533187
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83297848
115EZH2_27294783_Chip-Seq_ESCs_Mouse0.82958687
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82457083
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.82385526
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80941360
119CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78677539
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77632337
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76866284
122* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75349200
123* TCF4_22108803_ChIP-Seq_LS180_Human0.74825005
124CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74680361
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74267480
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74162052
127BCOR_27268052_Chip-Seq_Bcells_Human0.73778243
128CLOCK_20551151_ChIP-Seq_293T_Human0.73501289
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73404914
130RNF2_27304074_Chip-Seq_ESCs_Mouse0.72975582
131* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72764939
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.72485804
133* GATA3_21867929_ChIP-Seq_TH1_Mouse0.71181982
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.71139273
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.70369447
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.70087854
137LXR_22292898_ChIP-Seq_THP-1_Human0.69714849
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69280619
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68776178
140EGR1_19032775_ChIP-ChIP_M12_Human0.68671237
141GATA6_25053715_ChIP-Seq_YYC3_Human0.68086159
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67775908
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67775908
144* NANOG_20526341_ChIP-Seq_ESCs_Human0.66959135
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.66025302
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66025302
147P53_21459846_ChIP-Seq_SAOS-2_Human0.65639599
148RBPJ_21746931_ChIP-Seq_IB4_Human0.65299662
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64774255
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64352915
151FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.64160980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.54638452
2MP0005275_abnormal_skin_tensile5.19647243
3MP0010234_abnormal_vibrissa_follicle4.81699988
4MP0005501_abnormal_skin_physiology4.60501240
5MP0004381_abnormal_hair_follicle4.58896079
6MP0000579_abnormal_nail_morphology4.11877133
7MP0000383_abnormal_hair_follicle3.92400290
8MP0003941_abnormal_skin_development3.78430681
9MP0002254_reproductive_system_inflammat3.68965173
10MP0001216_abnormal_epidermal_layer3.43868599
11MP0010678_abnormal_skin_adnexa3.43203258
12MP0002060_abnormal_skin_morphology3.42725029
13MP0002098_abnormal_vibrissa_morphology3.28996163
14MP0000647_abnormal_sebaceous_gland3.25308383
15MP0010771_integument_phenotype3.10034962
16MP0003453_abnormal_keratinocyte_physiol3.06224248
17MP0004185_abnormal_adipocyte_glucose2.62477192
18MP0000427_abnormal_hair_cycle2.49058032
19MP0000467_abnormal_esophagus_morphology2.49032052
20MP0000377_abnormal_hair_follicle2.45265822
21MP0009780_abnormal_chondrocyte_physiolo2.30982404
22MP0004947_skin_inflammation2.15995660
23MP0003705_abnormal_hypodermis_morpholog2.07211645
24MP0000566_synostosis1.93326121
25MP0003011_delayed_dark_adaptation1.88205467
26MP0009379_abnormal_foot_pigmentation1.84912682
27MP0003566_abnormal_cell_adhesion1.68736458
28MP0000762_abnormal_tongue_morphology1.68062499
29MP0005377_hearing/vestibular/ear_phenot1.67650303
30MP0003878_abnormal_ear_physiology1.67650303
31MP0005451_abnormal_body_composition1.66414298
32MP0009931_abnormal_skin_appearance1.59466079
33MP0001243_abnormal_dermal_layer1.59175659
34MP0001346_abnormal_lacrimal_gland1.56830832
35MP0002009_preneoplasia1.55188008
36MP0001191_abnormal_skin_condition1.49581368
37MP0005666_abnormal_adipose_tissue1.47299703
38MP0000367_abnormal_coat/_hair1.41222783
39MP0005083_abnormal_biliary_tract1.38768880
40MP0002234_abnormal_pharynx_morphology1.38557853
41MP0005670_abnormal_white_adipose1.35414041
42MP0001188_hyperpigmentation1.34903937
43MP0001851_eye_inflammation1.18819393
44MP0001873_stomach_inflammation1.16430448
45MP0005375_adipose_tissue_phenotype1.06472502
46MP0005409_darkened_coat_color1.04846495
47MP0005367_renal/urinary_system_phenotyp1.00779645
48MP0000516_abnormal_urinary_system1.00779645
49MP0003136_yellow_coat_color0.97795826
50MP0004885_abnormal_endolymph0.95823549
51MP0001340_abnormal_eyelid_morphology0.93141606
52MP0010386_abnormal_urinary_bladder0.93027257
53MP0009053_abnormal_anal_canal0.91659304
54MP0005248_abnormal_Harderian_gland0.88817937
55MP0004272_abnormal_basement_membrane0.87579992
56MP0003183_abnormal_peptide_metabolism0.86587318
57MP0008004_abnormal_stomach_pH0.86143455
58MP0005023_abnormal_wound_healing0.85742382
59MP0003191_abnormal_cellular_cholesterol0.81207777
60MP0001727_abnormal_embryo_implantation0.79518630
61MP0004858_abnormal_nervous_system0.79278774
62MP0009672_abnormal_birth_weight0.78672033
63MP0005410_abnormal_fertilization0.78155650
64MP0003315_abnormal_perineum_morphology0.77613856
65MP0004264_abnormal_extraembryonic_tissu0.75965065
66MP0000537_abnormal_urethra_morphology0.75852375
67MP0008438_abnormal_cutaneous_collagen0.75262244
68MP0000678_abnormal_parathyroid_gland0.73577795
69MP0010352_gastrointestinal_tract_polyps0.73055753
70MP0003936_abnormal_reproductive_system0.72579613
71MP0004019_abnormal_vitamin_homeostasis0.72010126
72MP0000627_abnormal_mammary_gland0.70453473
73MP0000013_abnormal_adipose_tissue0.68495559
74MP0005408_hypopigmentation0.66938912
75MP0002971_abnormal_brown_adipose0.66707729
76MP0005058_abnormal_lysosome_morphology0.66576058
77MP0004233_abnormal_muscle_weight0.65560711
78MP0001984_abnormal_olfaction0.62458405
79MP0000003_abnormal_adipose_tissue0.58212008
80MP0001919_abnormal_reproductive_system0.57992889
81MP0004130_abnormal_muscle_cell0.57371195
82MP0003950_abnormal_plasma_membrane0.56911147
83MP0001765_abnormal_ion_homeostasis0.56599186
84MP0002277_abnormal_respiratory_mucosa0.55159604
85MP0002282_abnormal_trachea_morphology0.53623381
86MP0005646_abnormal_pituitary_gland0.52494709
87MP0003123_paternal_imprinting0.52234374
88MP0000462_abnormal_digestive_system0.50599349
89MP0001666_abnormal_nutrient_absorption0.49455613
90MP0005076_abnormal_cell_differentiation0.49299360
91MP0005647_abnormal_sex_gland0.48151061
92MP0002006_tumorigenesis0.47535617
93MP0006054_spinal_hemorrhage0.45636548
94MP0002837_dystrophic_cardiac_calcinosis0.45499821
95MP0002177_abnormal_outer_ear0.45487201
96MP0001784_abnormal_fluid_regulation0.44869489
97MP0002896_abnormal_bone_mineralization0.44386383
98MP0002166_altered_tumor_susceptibility0.44139689
99MP0002111_abnormal_tail_morphology0.42972937
100MP0000858_altered_metastatic_potential0.42963917
101MP0002909_abnormal_adrenal_gland0.42870947
102MP0005310_abnormal_salivary_gland0.42453109
103MP0003045_fibrosis0.41739043
104MP0001186_pigmentation_phenotype0.39652663
105MP0000465_gastrointestinal_hemorrhage0.39135972
106MP0000538_abnormal_urinary_bladder0.38962955
107MP0009384_cardiac_valve_regurgitation0.38904635
108MP0005075_abnormal_melanosome_morpholog0.38396869
109MP0004782_abnormal_surfactant_physiolog0.38350676
110MP0003763_abnormal_thymus_physiology0.36865959
111MP0003755_abnormal_palate_morphology0.36542592
112MP0002095_abnormal_skin_pigmentation0.36502264
113MP0002736_abnormal_nociception_after0.36156083
114MP0000015_abnormal_ear_pigmentation0.36136803
115MP0003938_abnormal_ear_development0.35877073
116MP0002168_other_aberrant_phenotype0.35025202
117MP0000613_abnormal_salivary_gland0.34223888
118MP0008260_abnormal_autophagy0.34169488
119MP0003436_decreased_susceptibility_to0.34165685
120MP0005503_abnormal_tendon_morphology0.33527097
121MP0000750_abnormal_muscle_regeneration0.33505131
122MP0005508_abnormal_skeleton_morphology0.33351910
123MP0001664_abnormal_digestion0.33081875
124MP0002970_abnormal_white_adipose0.31532808
125MP0001881_abnormal_mammary_gland0.30407833
126MP0010030_abnormal_orbit_morphology0.29954049
127MP0003638_abnormal_response/metabolism_0.29657580
128MP0001849_ear_inflammation0.27847249
129MP0002249_abnormal_larynx_morphology0.27369095
130MP0005334_abnormal_fat_pad0.23209304
131MP0002118_abnormal_lipid_homeostasis0.22801174
132MP0001661_extended_life_span0.22570118
133MP0000470_abnormal_stomach_morphology0.21674059
134MP0002163_abnormal_gland_morphology0.21045411
135MP0002877_abnormal_melanocyte_morpholog0.20434200
136MP0002108_abnormal_muscle_morphology0.19408958

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.40028043
2Woolly hair (HP:0002224)7.28255549
3Plantar hyperkeratosis (HP:0007556)6.13434992
4Parakeratosis (HP:0001036)5.99726566
5Fragile nails (HP:0001808)5.91601317
6Right ventricular cardiomyopathy (HP:0011663)5.91382696
7Palmoplantar hyperkeratosis (HP:0000972)5.82031561
8Abnormality of nail color (HP:0100643)5.68605941
9Palmar hyperkeratosis (HP:0010765)5.47998880
10Congenital ichthyosiform erythroderma (HP:0007431)5.47465448
11Onycholysis (HP:0001806)5.37234692
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.24987608
13Erythema (HP:0010783)5.19266288
14Milia (HP:0001056)5.07992650
15Lip pit (HP:0100267)4.94886321
16Increased IgE level (HP:0003212)4.86979654
17Pili torti (HP:0003777)4.45920781
18Erythroderma (HP:0001019)4.38799627
19Thick nail (HP:0001805)4.37323527
20Conjunctival hamartoma (HP:0100780)4.13667484
21Abnormality of secondary sexual hair (HP:0009888)4.08104989
22Abnormality of the axillary hair (HP:0100134)4.08104989
23Nail dystrophy (HP:0008404)4.06304690
24Acanthosis nigricans (HP:0000956)4.02480803
25Abnormal blistering of the skin (HP:0008066)3.93224224
26Alopecia of scalp (HP:0002293)3.72529655
27Sparse eyelashes (HP:0000653)3.41524770
28Absent eyelashes (HP:0000561)3.29426061
29Hypohidrosis (HP:0000966)3.28848364
30Brittle hair (HP:0002299)3.22122770
31Concave nail (HP:0001598)3.17394183
32Popliteal pterygium (HP:0009756)3.11360192
33Sparse lateral eyebrow (HP:0005338)3.11201149
34Abnormal hair laboratory examination (HP:0003328)3.10876027
35Hyporeflexia of lower limbs (HP:0002600)3.09872562
36Asymmetry of the thorax (HP:0001555)3.08264213
37Corneal erosion (HP:0200020)3.01765662
38Ridged nail (HP:0001807)2.99305524
39Ectropion (HP:0000656)2.96998509
40Congenital, generalized hypertrichosis (HP:0004540)2.91142982
41Natal tooth (HP:0000695)2.90509651
42Palmoplantar keratoderma (HP:0000982)2.88439027
43Curly hair (HP:0002212)2.87962495
44Distal lower limb muscle weakness (HP:0009053)2.84528672
45Thin bony cortex (HP:0002753)2.83986568
46Germ cell neoplasia (HP:0100728)2.76020123
47Ventricular tachycardia (HP:0004756)2.73698799
48Atrophic scars (HP:0001075)2.70832967
49Pruritus (HP:0000989)2.60998387
50Advanced eruption of teeth (HP:0006288)2.58941351
51Abnormality of the salivary glands (HP:0010286)2.55801033
52Follicular hyperkeratosis (HP:0007502)2.55534174
53Gangrene (HP:0100758)2.41812771
54Abnormal hemoglobin (HP:0011902)2.40226074
55Hypoplastic labia majora (HP:0000059)2.35306634
56J-shaped sella turcica (HP:0002680)2.33606494
57Sparse scalp hair (HP:0002209)2.30137170
58Abnormality of cells of the erythroid lineage (HP:0012130)2.29772248
59Aplasia cutis congenita (HP:0001057)2.24762096
60Hamartoma of the eye (HP:0010568)2.23768647
61Fragile skin (HP:0001030)2.21655336
62Taurodontia (HP:0000679)2.19960592
63Abnormality of permanent molar morphology (HP:0011071)2.19960592
64Abnormality of the dental root (HP:0006486)2.19960592
65Down-sloping shoulders (HP:0200021)2.19821190
66Pterygium (HP:0001059)2.17199375
67Flat acetabular roof (HP:0003180)2.14878781
68Oligodontia (HP:0000677)2.14577169
69Abnormality of the labia majora (HP:0012881)2.11516318
70Aplasia of the phalanges of the hand (HP:0009802)2.11283267
71Aplasia involving bones of the extremities (HP:0009825)2.11283267
72Aplasia involving bones of the upper limbs (HP:0009823)2.11283267
73Breast carcinoma (HP:0003002)2.06168716
74Hamartoma (HP:0010566)2.05917610
75Abnormality of molar morphology (HP:0011070)2.02577411
76Abnormality of molar (HP:0011077)2.02577411
77Increased connective tissue (HP:0009025)2.02283439
78Testicular neoplasm (HP:0010788)2.00904444
79Lymphangioma (HP:0100764)1.96853790
80Reticulocytopenia (HP:0001896)1.89900757
81Fatigable weakness (HP:0003473)1.89492470
82Abnormality of the neuromuscular junction (HP:0003398)1.89492470
83Hypoplasia of dental enamel (HP:0006297)1.89203646
84Selective tooth agenesis (HP:0001592)1.87665678
85Absent eyebrow (HP:0002223)1.86375950
86Type 1 muscle fiber predominance (HP:0003803)1.86069213
87Abnormality of hair growth rate (HP:0011363)1.84705757
88Slow-growing hair (HP:0002217)1.84705757
89Dry skin (HP:0000958)1.82551873
90Spinal cord compression (HP:0002176)1.81696891
91Enlarged penis (HP:0000040)1.80912139
92Macroorchidism (HP:0000053)1.79176302
93Abnormal number of erythroid precursors (HP:0012131)1.78708396
94Absent hair (HP:0002298)1.77941125
95Hyperparathyroidism (HP:0000843)1.77664154
96Melanocytic nevus (HP:0000995)1.77012444
97Areflexia of lower limbs (HP:0002522)1.76111313
98Myopathic facies (HP:0002058)1.75872569
99Hypodontia (HP:0000668)1.75813846
100Septate vagina (HP:0001153)1.74850733
101Furrowed tongue (HP:0000221)1.71931446
102Amelogenesis imperfecta (HP:0000705)1.71896579
103Achilles tendon contracture (HP:0001771)1.71614465
104Severe Myopia (HP:0011003)1.71589091
105Neck muscle weakness (HP:0000467)1.70795853
106Testicular atrophy (HP:0000029)1.70357846
107Corneal dystrophy (HP:0001131)1.69938088
108Skin pits (HP:0100276)1.69623691
109Difficulty running (HP:0009046)1.66294130
110Abnormality of the gastric mucosa (HP:0004295)1.65056943
111Congenital glaucoma (HP:0001087)1.64649185
112Exostoses (HP:0100777)1.64489708
113Abnormality of the frontal sinuses (HP:0002687)1.64253999
114Trismus (HP:0000211)1.63302208
115Blepharitis (HP:0000498)1.62185974
116Microglossia (HP:0000171)1.60553875
117Upper limb muscle weakness (HP:0003484)1.60497764
118Ulnar claw (HP:0001178)1.60496475
119Hypoparathyroidism (HP:0000829)1.60469876
120Abnormality of the distal phalanges of the toes (HP:0010182)1.59952333
121Nasolacrimal duct obstruction (HP:0000579)1.59919452
122Abnormal umbilical cord blood vessels (HP:0011403)1.59865258
123Single umbilical artery (HP:0001195)1.59865258
124Abnormality of the fetal cardiovascular system (HP:0010948)1.59865258
125Labial hypoplasia (HP:0000066)1.59618828
126Dehydration (HP:0001944)1.59029475
127Abnormality of the dental pulp (HP:0006479)1.57570535
128Anhidrosis (HP:0000970)1.56560040
129Oral leukoplakia (HP:0002745)1.55567804
130Seborrheic dermatitis (HP:0001051)1.55301008
131Fine hair (HP:0002213)1.54799908
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.53014319
133Broad face (HP:0000283)1.52043780
134Autoamputation (HP:0001218)1.51789319
135Hyperacusis (HP:0010780)1.51264452
136Depressed nasal tip (HP:0000437)1.49709809
137Renal dysplasia (HP:0000110)1.47621095
138Generalized hyperpigmentation (HP:0007440)1.47324905
139Preauricular skin tag (HP:0000384)1.47284337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.89730002
2MST1R4.54262002
3MAP3K34.03141649
4MST44.02895826
5FER3.88989662
6MAPKAPK33.46062765
7MAP3K23.25918253
8EPHA22.47310983
9PIK3CG2.38498780
10TESK12.24577068
11ERN12.23860691
12SMG12.18085469
13EPHB22.08481323
14RPS6KB22.05445222
15BCR2.02790935
16PDK42.00793564
17PDK32.00793564
18TTN1.89543546
19TRPM71.83491190
20TNK21.71761602
21MAPKAPK51.63214597
22BLK1.61512860
23STK241.58713668
24ICK1.55891486
25MET1.48662223
26PIM21.46820217
27MAP3K121.45624175
28TESK21.45389375
29NEK61.38839074
30MAP3K91.37433395
31PDK21.36077802
32EPHA31.34782439
33GRK61.34670528
34FGFR21.33898288
35LRRK21.33029131
36SCYL21.30060010
37BCKDK1.24198157
38LATS11.21291332
39CDK71.18230768
40GRK11.17379244
41RPS6KA21.14720707
42CDK121.12230139
43ERBB31.11015264
44MUSK1.10142312
45PAK41.09699423
46MAP3K11.08488731
47RIPK41.08415672
48TRIB31.04965930
49VRK21.04803417
50PBK1.04131605
51FGFR41.00424026
52MAP2K61.00199657
53RET0.99943081
54TAOK10.97850827
55EPHB10.95812568
56MAPKAPK20.92849369
57EIF2AK10.92543884
58EEF2K0.92510196
59IRAK30.92427032
60SIK30.91259005
61ILK0.90565092
62NME10.90146576
63MAP3K110.89771475
64MYLK0.89547182
65MTOR0.89385681
66CHUK0.87322793
67MAP2K10.74580494
68PRKCI0.74220234
69MAPK150.73558121
70DYRK1B0.71441813
71STK100.69899727
72PRKD20.69241381
73MATK0.67345167
74NTRK20.66759628
75LATS20.64926546
76CAMK1D0.64689435
77PTK60.64523830
78RPS6KB10.64399989
79RIPK10.63999534
80GRK70.63864443
81BMPR1B0.63712189
82PKN10.63321151
83DDR20.60910872
84MAP3K70.57503327
85CAMKK10.55169293
86RPS6KL10.55110026
87RPS6KC10.55110026
88STK110.54678803
89TBK10.54574009
90CDK60.54475418
91LMTK20.54072588
92STK390.54000023
93FGFR10.53074692
94FGFR30.53055477
95PRKD30.52592499
96IKBKE0.52131874
97OBSCN0.50766607
98LIMK10.49853560
99PDPK10.49525161
100TGFBR10.47733731
101MAPK120.44751227
102MARK20.43168508
103PTK20.43143478
104SIK10.42423819
105PIK3CA0.42315659
106PDGFRA0.41921305
107ERBB40.41862622
108GRK50.41837772
109ADRBK10.41817307
110HIPK20.41747473
111RPS6KA60.41665305
112CDK30.41326207
113KSR20.39299951
114TGFBR20.38908380
115EIF2AK20.37925905
116MAP2K40.37861435
117TTK0.37861125
118DMPK0.36932066
119TAF10.34588634
120ROCK20.34231882
121NME20.33208277
122RPS6KA10.32837665
123AKT20.32704014
124ERBB20.32638540
125PRKCE0.31239189
126MAPK40.29212751
127SRC0.27472709
128IRAK20.27068283
129PRKD10.26515903
130MAP3K60.26508569
131PDGFRB0.26135616
132MAP2K20.26080864
133FGR0.25986096
134WNK40.25853249
135GSK3A0.25707485
136CASK0.25562080
137MAPK80.25214000
138PRKCA0.24709281
139CAMK2G0.24587233
140PDK10.24134740
141CDC42BPA0.23902533
142TYRO30.18989814
143IKBKB0.18805429
144MAPK90.17887958
145PRPF4B0.17771936
146STK380.13320325

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.97864411
2Sphingolipid metabolism_Homo sapiens_hsa006003.51928822
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.49261015
4Linoleic acid metabolism_Homo sapiens_hsa005913.38923931
5Ribosome_Homo sapiens_hsa030103.27503646
6Arachidonic acid metabolism_Homo sapiens_hsa005902.87155750
7Fatty acid biosynthesis_Homo sapiens_hsa000612.85610750
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.69349891
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27739234
10Caffeine metabolism_Homo sapiens_hsa002322.14941248
11Endometrial cancer_Homo sapiens_hsa052132.10929587
12PPAR signaling pathway_Homo sapiens_hsa033202.07768919
13Acute myeloid leukemia_Homo sapiens_hsa052212.01602247
14Ether lipid metabolism_Homo sapiens_hsa005651.97808136
15Fatty acid metabolism_Homo sapiens_hsa012121.89944264
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84401826
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.83214345
18Retinol metabolism_Homo sapiens_hsa008301.73226365
19Fat digestion and absorption_Homo sapiens_hsa049751.70969996
20Basal cell carcinoma_Homo sapiens_hsa052171.70106627
21Notch signaling pathway_Homo sapiens_hsa043301.67425446
22Fructose and mannose metabolism_Homo sapiens_hsa000511.62283134
23Choline metabolism in cancer_Homo sapiens_hsa052311.58972030
24Prolactin signaling pathway_Homo sapiens_hsa049171.55203803
25Steroid biosynthesis_Homo sapiens_hsa001001.52860115
26Propanoate metabolism_Homo sapiens_hsa006401.52377653
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52246191
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51957259
29Hedgehog signaling pathway_Homo sapiens_hsa043401.48110943
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.46775058
31Insulin signaling pathway_Homo sapiens_hsa049101.45670941
32Other glycan degradation_Homo sapiens_hsa005111.43774079
33Non-small cell lung cancer_Homo sapiens_hsa052231.43749916
34Prostate cancer_Homo sapiens_hsa052151.40128317
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38789613
36Oxidative phosphorylation_Homo sapiens_hsa001901.37402619
37mTOR signaling pathway_Homo sapiens_hsa041501.37032606
38Fatty acid degradation_Homo sapiens_hsa000711.32430264
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31040479
40Bladder cancer_Homo sapiens_hsa052191.30917442
41Glioma_Homo sapiens_hsa052141.30714158
42Renin secretion_Homo sapiens_hsa049241.29049064
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26690285
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17844959
45Lysosome_Homo sapiens_hsa041421.16454245
46ECM-receptor interaction_Homo sapiens_hsa045121.15605980
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.14861151
48* Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14083961
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10964398
50Renal cell carcinoma_Homo sapiens_hsa052111.10744227
51Collecting duct acid secretion_Homo sapiens_hsa049661.10382180
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10114005
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.09416047
54Glycerolipid metabolism_Homo sapiens_hsa005611.08868534
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08499286
56Sulfur metabolism_Homo sapiens_hsa009201.07575935
57Chronic myeloid leukemia_Homo sapiens_hsa052201.07406475
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06123643
59Pancreatic cancer_Homo sapiens_hsa052121.05114997
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04126312
61Tight junction_Homo sapiens_hsa045301.04014707
62* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01614828
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.99451374
64Staphylococcus aureus infection_Homo sapiens_hsa051500.98847617
65VEGF signaling pathway_Homo sapiens_hsa043700.95210117
66Pentose phosphate pathway_Homo sapiens_hsa000300.94259222
67Alzheimers disease_Homo sapiens_hsa050100.94216663
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.93242307
69Glutathione metabolism_Homo sapiens_hsa004800.91735871
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89267692
71Adherens junction_Homo sapiens_hsa045200.85704964
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84952323
73* Chemical carcinogenesis_Homo sapiens_hsa052040.83968852
74Axon guidance_Homo sapiens_hsa043600.82395419
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82268172
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81251586
77GnRH signaling pathway_Homo sapiens_hsa049120.79674195
78Melanogenesis_Homo sapiens_hsa049160.79642302
79Arginine and proline metabolism_Homo sapiens_hsa003300.79062794
80Pancreatic secretion_Homo sapiens_hsa049720.77294113
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.75411521
82Salivary secretion_Homo sapiens_hsa049700.73062420
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.73025353
84Vitamin digestion and absorption_Homo sapiens_hsa049770.70424612
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70147460
86Inositol phosphate metabolism_Homo sapiens_hsa005620.70041745
87Proteoglycans in cancer_Homo sapiens_hsa052050.68882237
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.66041275
89Hippo signaling pathway_Homo sapiens_hsa043900.66027526
90* Histidine metabolism_Homo sapiens_hsa003400.65499608
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64797165
92Dorso-ventral axis formation_Homo sapiens_hsa043200.63766764
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.62946599
94Serotonergic synapse_Homo sapiens_hsa047260.62725804
95MicroRNAs in cancer_Homo sapiens_hsa052060.62048465
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59783508
97Pyruvate metabolism_Homo sapiens_hsa006200.59219744
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58914909
99Mineral absorption_Homo sapiens_hsa049780.57780631
100Melanoma_Homo sapiens_hsa052180.57706606
101Ovarian steroidogenesis_Homo sapiens_hsa049130.56799217
102Gastric acid secretion_Homo sapiens_hsa049710.56784240
103Amoebiasis_Homo sapiens_hsa051460.56503793
104p53 signaling pathway_Homo sapiens_hsa041150.55628793
105N-Glycan biosynthesis_Homo sapiens_hsa005100.54308039
106Protein digestion and absorption_Homo sapiens_hsa049740.53562326
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52632281
108Parkinsons disease_Homo sapiens_hsa050120.50892454
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50440446
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50291911
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49246201
112HIF-1 signaling pathway_Homo sapiens_hsa040660.48363543
113Phototransduction_Homo sapiens_hsa047440.47802461
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47220192
115Small cell lung cancer_Homo sapiens_hsa052220.46137028
116Long-term depression_Homo sapiens_hsa047300.44366408
117Sulfur relay system_Homo sapiens_hsa041220.43800717
118Calcium signaling pathway_Homo sapiens_hsa040200.43696634
119ABC transporters_Homo sapiens_hsa020100.43672018
120Ras signaling pathway_Homo sapiens_hsa040140.42744874
121Vibrio cholerae infection_Homo sapiens_hsa051100.42011846
122* Phenylalanine metabolism_Homo sapiens_hsa003600.41176733
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.41063359
124* beta-Alanine metabolism_Homo sapiens_hsa004100.40205727
125Cardiac muscle contraction_Homo sapiens_hsa042600.40204858
126Thyroid cancer_Homo sapiens_hsa052160.39503317
127Peroxisome_Homo sapiens_hsa041460.37206942
128Estrogen signaling pathway_Homo sapiens_hsa049150.36102779
129Lysine degradation_Homo sapiens_hsa003100.34578325
130Galactose metabolism_Homo sapiens_hsa000520.33302821
131AMPK signaling pathway_Homo sapiens_hsa041520.32762474
132Hepatitis B_Homo sapiens_hsa051610.32655474
133Platelet activation_Homo sapiens_hsa046110.32626223
134Glucagon signaling pathway_Homo sapiens_hsa049220.31707596
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31521225
136Endocytosis_Homo sapiens_hsa041440.31190056
137Oxytocin signaling pathway_Homo sapiens_hsa049210.28916894
138* Tyrosine metabolism_Homo sapiens_hsa003500.28553593
139Amphetamine addiction_Homo sapiens_hsa050310.28356284
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28292713
141Insulin resistance_Homo sapiens_hsa049310.27587736
142Hepatitis C_Homo sapiens_hsa051600.26412835
143ErbB signaling pathway_Homo sapiens_hsa040120.21652636
144Butanoate metabolism_Homo sapiens_hsa006500.20468678
145Toxoplasmosis_Homo sapiens_hsa051450.19629929
146Huntingtons disease_Homo sapiens_hsa050160.18789658
147Wnt signaling pathway_Homo sapiens_hsa043100.18545863
148Pathways in cancer_Homo sapiens_hsa052000.17538107

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