ALDH5A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.74839253
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.74839253
3L-phenylalanine metabolic process (GO:0006558)4.48164371
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.48164371
5ethanol oxidation (GO:0006069)4.06513563
6aromatic amino acid family catabolic process (GO:0009074)3.98596964
7epoxygenase P450 pathway (GO:0019373)3.91824407
8gamma-aminobutyric acid transport (GO:0015812)3.85651195
9creatine metabolic process (GO:0006600)3.84237569
10alpha-linolenic acid metabolic process (GO:0036109)3.82130246
11positive regulation of synapse maturation (GO:0090129)3.78036119
12dicarboxylic acid biosynthetic process (GO:0043650)3.77949251
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77397048
14synaptic vesicle maturation (GO:0016188)3.70134183
15* glutamate metabolic process (GO:0006536)3.69620458
16cellular ketone body metabolic process (GO:0046950)3.68466379
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68058773
18bile acid biosynthetic process (GO:0006699)3.66263368
19potassium ion import (GO:0010107)3.61066293
20locomotory exploration behavior (GO:0035641)3.60625719
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52390345
22neuronal action potential propagation (GO:0019227)3.52043194
23kynurenine metabolic process (GO:0070189)3.52027618
24glyoxylate metabolic process (GO:0046487)3.49237107
25lysine metabolic process (GO:0006553)3.44399596
26lysine catabolic process (GO:0006554)3.44399596
27dicarboxylic acid catabolic process (GO:0043649)3.42456609
28omega-hydroxylase P450 pathway (GO:0097267)3.41077019
29glutamate secretion (GO:0014047)3.36784804
30cysteine metabolic process (GO:0006534)3.36533998
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36245931
32postsynaptic membrane organization (GO:0001941)3.33050650
33indole-containing compound catabolic process (GO:0042436)3.32696750
34indolalkylamine catabolic process (GO:0046218)3.32696750
35tryptophan catabolic process (GO:0006569)3.32696750
36vocalization behavior (GO:0071625)3.31642392
37cerebellar granule cell differentiation (GO:0021707)3.23070833
38high-density lipoprotein particle remodeling (GO:0034375)3.22941569
39* neurotransmitter secretion (GO:0007269)3.21334487
40urea metabolic process (GO:0019627)3.21125564
41urea cycle (GO:0000050)3.21125564
42aspartate family amino acid catabolic process (GO:0009068)3.20964988
43L-amino acid import (GO:0043092)3.19912459
44sulfur amino acid catabolic process (GO:0000098)3.19148491
45synaptic vesicle exocytosis (GO:0016079)3.17981037
46ketone body metabolic process (GO:1902224)3.17358448
47blood coagulation, intrinsic pathway (GO:0007597)3.15771744
48C4-dicarboxylate transport (GO:0015740)3.15227411
49bile acid metabolic process (GO:0008206)3.12989537
50neurotransmitter uptake (GO:0001504)3.11950979
51cellular sodium ion homeostasis (GO:0006883)3.10660113
52regulation of synapse maturation (GO:0090128)3.10241405
53tryptophan metabolic process (GO:0006568)3.09398459
54alpha-amino acid catabolic process (GO:1901606)3.08593729
55ethanol metabolic process (GO:0006067)3.08239600
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07787962
57neurotransmitter-gated ion channel clustering (GO:0072578)3.07164627
58cellular modified amino acid catabolic process (GO:0042219)3.04411979
59potassium ion homeostasis (GO:0055075)2.97674261
60drug catabolic process (GO:0042737)2.97226238
61sarcoplasmic reticulum calcium ion transport (GO:0070296)2.96269599
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95764704
63nitrogen cycle metabolic process (GO:0071941)2.94734025
64* cellular amino acid catabolic process (GO:0009063)2.94154378
65regulation of glutamate receptor signaling pathway (GO:1900449)2.93882316
66coenzyme catabolic process (GO:0009109)2.93816505
67NADH metabolic process (GO:0006734)2.93785363
68serine family amino acid catabolic process (GO:0009071)2.93039532
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92226268
70reverse cholesterol transport (GO:0043691)2.91068785
71cellular potassium ion homeostasis (GO:0030007)2.90540014
72negative regulation of fibrinolysis (GO:0051918)2.89906187
73oxaloacetate metabolic process (GO:0006107)2.88586127
74regulation of synaptic vesicle exocytosis (GO:2000300)2.87585710
75aromatic amino acid family metabolic process (GO:0009072)2.87549470
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86809177
77response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.86640926
78sodium ion export (GO:0071436)2.84918427
79oxidative demethylation (GO:0070989)2.83002708
80very-low-density lipoprotein particle assembly (GO:0034379)2.82101934
81tyrosine metabolic process (GO:0006570)2.82094295
82plasma lipoprotein particle remodeling (GO:0034369)2.81841568
83protein-lipid complex remodeling (GO:0034368)2.81841568
84macromolecular complex remodeling (GO:0034367)2.81841568
85regulation of fibrinolysis (GO:0051917)2.79900032
86layer formation in cerebral cortex (GO:0021819)2.77396290
87homocysteine metabolic process (GO:0050667)2.77360228
88amino-acid betaine metabolic process (GO:0006577)2.75593314
89central nervous system myelination (GO:0022010)2.75518689
90axon ensheathment in central nervous system (GO:0032291)2.75518689
91protein localization to synapse (GO:0035418)2.75201637
92peptidyl-glutamic acid carboxylation (GO:0017187)2.74748859
93protein carboxylation (GO:0018214)2.74748859
94regulation of cholesterol esterification (GO:0010872)2.74719013
95regulation of protein activation cascade (GO:2000257)2.74099201
96complement activation, alternative pathway (GO:0006957)2.73867095
97membrane depolarization during action potential (GO:0086010)2.72958076
98synaptic vesicle docking involved in exocytosis (GO:0016081)2.71989437
99amino acid import (GO:0043090)2.71515035
100regulation of triglyceride catabolic process (GO:0010896)2.71457276
101regulation of neuronal synaptic plasticity (GO:0048168)2.71219684
102exogenous drug catabolic process (GO:0042738)2.70873318
103drug metabolic process (GO:0017144)2.70831030
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70555597
105response to mercury ion (GO:0046689)2.69757077
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.69748915
1072-oxoglutarate metabolic process (GO:0006103)2.69267164
108regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68657829
109cell communication by electrical coupling (GO:0010644)2.68635442
110regulation of synapse structural plasticity (GO:0051823)2.68095553
111triglyceride homeostasis (GO:0070328)2.67444726
112acylglycerol homeostasis (GO:0055090)2.67444726
113acetyl-CoA metabolic process (GO:0006084)2.67207337
114synaptic transmission, glutamatergic (GO:0035249)2.67170144
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66343947
116detection of calcium ion (GO:0005513)2.65849157
117* short-chain fatty acid metabolic process (GO:0046459)2.65426083
118glycine metabolic process (GO:0006544)2.63868628
119exploration behavior (GO:0035640)2.63831676
120glutamine family amino acid catabolic process (GO:0009065)2.62902713
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.62768565
122pyrimidine nucleobase catabolic process (GO:0006208)2.62526934
123cellular glucuronidation (GO:0052695)2.62264394
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61837928
125negative regulation of cholesterol transport (GO:0032375)2.61343507
126negative regulation of sterol transport (GO:0032372)2.61343507
127regulation of synaptic vesicle transport (GO:1902803)2.61017927
128presynaptic membrane assembly (GO:0097105)2.60827270
129fructose metabolic process (GO:0006000)2.60764151
130skeletal muscle contraction (GO:0003009)2.60567043
131* neurotransmitter transport (GO:0006836)2.60439188
132negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59878730
133neuromuscular process controlling posture (GO:0050884)2.58710488
134* regulation of neurotransmitter levels (GO:0001505)2.57946110
135activation of protein kinase A activity (GO:0034199)2.57263895
136alanine transport (GO:0032328)2.57180785
137regulation of bile acid biosynthetic process (GO:0070857)2.56202493
138proline transport (GO:0015824)2.53945802
139regulation of complement activation (GO:0030449)2.52934480
140neuron cell-cell adhesion (GO:0007158)2.52605419
141regulation of cholesterol homeostasis (GO:2000188)2.51842340
142* organic acid catabolic process (GO:0016054)2.49967770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.78123834
2EZH2_22144423_ChIP-Seq_EOC_Human3.91263972
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.37236721
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.79110710
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69411834
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59689976
7GBX2_23144817_ChIP-Seq_PC3_Human2.53668981
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41482602
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40259699
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30059982
11IGF1R_20145208_ChIP-Seq_DFB_Human2.21439059
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19676090
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18375253
14DROSHA_22980978_ChIP-Seq_HELA_Human2.09915379
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09157013
16REST_21632747_ChIP-Seq_MESCs_Mouse2.08059847
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05168519
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04130398
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04130398
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03537599
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02895250
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.01409287
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99684001
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91724163
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87963760
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87330682
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85876166
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85069831
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82943215
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.78772055
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75363346
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.72997776
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72411810
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69165637
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.68929571
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66401854
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.65535293
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.64454208
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50916452
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49211723
41AR_21572438_ChIP-Seq_LNCaP_Human1.47922863
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.47142984
43TAF15_26573619_Chip-Seq_HEK293_Human1.42900226
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40449937
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39335079
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30962580
47SMAD4_21799915_ChIP-Seq_A2780_Human1.29119080
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28828974
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27498045
50* FOXA2_19822575_ChIP-Seq_HepG2_Human1.24530389
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24433041
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22872067
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22867767
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.20166596
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.17720580
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16712313
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.16233030
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15250587
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14029718
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12038370
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11962365
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10584161
63ER_23166858_ChIP-Seq_MCF-7_Human1.10221282
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09747256
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09512970
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08129470
67* AR_19668381_ChIP-Seq_PC3_Human1.07934854
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07118010
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05861414
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05781358
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05538979
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04854827
73STAT3_23295773_ChIP-Seq_U87_Human1.01556423
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.01346300
75ZNF274_21170338_ChIP-Seq_K562_Hela1.01324503
76HTT_18923047_ChIP-ChIP_STHdh_Human0.99920230
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99754446
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98925262
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.98008666
80SMAD4_21741376_ChIP-Seq_HESCs_Human0.97543170
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97391579
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97075439
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97058097
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97025683
85BCAT_22108803_ChIP-Seq_LS180_Human0.95170778
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94557739
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94308225
88* AR_25329375_ChIP-Seq_VCAP_Human0.93370616
89* P300_19829295_ChIP-Seq_ESCs_Human0.93210796
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92744410
91RNF2_27304074_Chip-Seq_NSC_Mouse0.91943004
92ESR1_20079471_ChIP-ChIP_T-47D_Human0.91465419
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91145613
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89213571
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86787911
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.86754766
97RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86384131
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85802149
99KDM2B_26808549_Chip-Seq_K562_Human0.84441054
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.84241423
101* GATA1_19941827_ChIP-Seq_MEL_Mouse0.84088131
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83906133
103TCF4_23295773_ChIP-Seq_U87_Human0.83845309
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83811104
105AHR_22903824_ChIP-Seq_MCF-7_Human0.82964698
106CTCF_27219007_Chip-Seq_Bcells_Human0.82336240
107MYC_22102868_ChIP-Seq_BL_Human0.82025545
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.80833152
109NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80544188
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80510313
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.80500750
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80467791
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80009834
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79578238
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78665278
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78403870
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77909739
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77909739
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77788374
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.77733652
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77490904
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.77020530
123RXR_22108803_ChIP-Seq_LS180_Human0.76841056
124SMC4_20622854_ChIP-Seq_HELA_Human0.75709820
125OCT4_18555785_Chip-Seq_ESCs_Mouse0.75235213
126E2F1_17053090_ChIP-ChIP_MCF-7_Human0.73501877
127OCT4_19829295_ChIP-Seq_ESCs_Human0.73335731
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73079085
129* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72993578
130CTCF_18555785_Chip-Seq_ESCs_Mouse0.72968284
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.72081671
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71572900
133P53_22387025_ChIP-Seq_ESCs_Mouse0.71549415
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69664343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.99409960
2MP0005360_urolithiasis4.43695958
3MP0004859_abnormal_synaptic_plasticity4.15861576
4MP0005085_abnormal_gallbladder_physiolo3.92154123
5MP0005365_abnormal_bile_salt3.65218355
6MP0008875_abnormal_xenobiotic_pharmacok3.13991079
7MP0002822_catalepsy2.92118710
8MP0003635_abnormal_synaptic_transmissio2.76386301
9MP0003880_abnormal_central_pattern2.70979231
10MP0004270_analgesia2.45951682
11MP0009745_abnormal_behavioral_response2.35389785
12MP0003252_abnormal_bile_duct2.28706331
13MP0010329_abnormal_lipoprotein_level2.28171189
14MP0004145_abnormal_muscle_electrophysio2.25251423
15MP0002063_abnormal_learning/memory/cond2.19257146
16* MP0002064_seizures2.18298813
17* MP0009046_muscle_twitch1.93263146
18MP0003329_amyloid_beta_deposits1.93231669
19MP0003195_calcinosis1.90941174
20* MP0005332_abnormal_amino_acid1.89514180
21MP0001486_abnormal_startle_reflex1.85651235
22MP0009780_abnormal_chondrocyte_physiolo1.84845170
23MP0002572_abnormal_emotion/affect_behav1.83991851
24MP0005423_abnormal_somatic_nervous1.80325145
25MP0003806_abnormal_nucleotide_metabolis1.76508136
26MP0003787_abnormal_imprinting1.74750674
27MP0005083_abnormal_biliary_tract1.73488874
28MP0001986_abnormal_taste_sensitivity1.72805739
29MP0002837_dystrophic_cardiac_calcinosis1.72451860
30* MP0002272_abnormal_nervous_system1.71558719
31MP0002909_abnormal_adrenal_gland1.66165044
32MP0001968_abnormal_touch/_nociception1.58967520
33MP0001501_abnormal_sleep_pattern1.56178952
34MP0002734_abnormal_mechanical_nocicepti1.55104545
35MP0003690_abnormal_glial_cell1.54397162
36MP0005646_abnormal_pituitary_gland1.52788061
37MP0004885_abnormal_endolymph1.52470095
38MP0004147_increased_porphyrin_level1.51926035
39MP0001666_abnormal_nutrient_absorption1.50933801
40MP0002118_abnormal_lipid_homeostasis1.50554257
41MP0004043_abnormal_pH_regulation1.41486649
42MP0001440_abnormal_grooming_behavior1.40631916
43MP0009840_abnormal_foam_cell1.35087689
44MP0004924_abnormal_behavior1.32933022
45MP0005386_behavior/neurological_phenoty1.32933022
46MP0002638_abnormal_pupillary_reflex1.32039018
47MP0000747_muscle_weakness1.31898655
48MP0005535_abnormal_body_temperature1.30638061
49MP0004130_abnormal_muscle_cell1.28693129
50MP0005584_abnormal_enzyme/coenzyme_acti1.25170291
51MP0002067_abnormal_sensory_capabilities1.24931202
52MP0003868_abnormal_feces_composition1.23555130
53MP0002733_abnormal_thermal_nociception1.22192005
54MP0000604_amyloidosis1.21554283
55MP0003633_abnormal_nervous_system1.18687001
56MP0001984_abnormal_olfaction1.15194889
57MP0000749_muscle_degeneration1.14493502
58MP0008569_lethality_at_weaning1.13434303
59MP0002557_abnormal_social/conspecific_i1.13076066
60MP0002332_abnormal_exercise_endurance1.12816305
61MP0004019_abnormal_vitamin_homeostasis1.12125806
62MP0004036_abnormal_muscle_relaxation1.11979719
63MP0004858_abnormal_nervous_system1.10150300
64MP0004142_abnormal_muscle_tone1.09361184
65MP0002269_muscular_atrophy1.09193747
66MP0003656_abnormal_erythrocyte_physiolo1.07686558
67MP0002736_abnormal_nociception_after1.06043832
68MP0002106_abnormal_muscle_physiology1.04846492
69MP0003123_paternal_imprinting1.04321206
70MP0002009_preneoplasia1.03890428
71MP0008872_abnormal_physiological_respon1.02779813
72MP0001970_abnormal_pain_threshold1.02150517
73MP0006276_abnormal_autonomic_nervous1.02104915
74MP0000955_abnormal_spinal_cord1.01131045
75* MP0002066_abnormal_motor_capabilities/c0.99894510
76MP0008874_decreased_physiological_sensi0.98430209
77MP0004811_abnormal_neuron_physiology0.97435914
78MP0003631_nervous_system_phenotype0.96802482
79MP0005670_abnormal_white_adipose0.96795913
80MP0001661_extended_life_span0.96319353
81MP0003121_genomic_imprinting0.95887692
82MP0003879_abnormal_hair_cell0.93471391
83MP0000609_abnormal_liver_physiology0.93253390
84MP0000778_abnormal_nervous_system0.92996812
85MP0002735_abnormal_chemical_nociception0.92677362
86MP0002078_abnormal_glucose_homeostasis0.92439513
87MP0004215_abnormal_myocardial_fiber0.92071673
88MP0000566_synostosis0.91345149
89MP0001502_abnormal_circadian_rhythm0.90955252
90MP0004087_abnormal_muscle_fiber0.89314532
91MP0002090_abnormal_vision0.87586494
92MP0002184_abnormal_innervation0.87502077
93MP0000569_abnormal_digit_pigmentation0.87021217
94MP0005319_abnormal_enzyme/_coenzyme0.86734644
95MP0002069_abnormal_eating/drinking_beha0.86370712
96MP0002229_neurodegeneration0.86158570
97MP0008961_abnormal_basal_metabolism0.86006262
98MP0000751_myopathy0.85918126
99MP0003075_altered_response_to0.84607124
100MP0003137_abnormal_impulse_conducting0.83832909
101MP0004085_abnormal_heartbeat0.83457924
102MP0002876_abnormal_thyroid_physiology0.82893547
103MP0002882_abnormal_neuron_morphology0.82843714
104MP0005451_abnormal_body_composition0.82347708
105MP0008877_abnormal_DNA_methylation0.81779640
106MP0001529_abnormal_vocalization0.81411670
107MP0005551_abnormal_eye_electrophysiolog0.80676496
108MP0002138_abnormal_hepatobiliary_system0.80405355
109MP0000013_abnormal_adipose_tissue0.79631544
110MP0000920_abnormal_myelination0.79411799
111MP0005369_muscle_phenotype0.78583472
112MP0003632_abnormal_nervous_system0.78513158
113MP0001177_atelectasis0.75772616
114MP0004742_abnormal_vestibular_system0.75275233
115MP0003191_abnormal_cellular_cholesterol0.73964429
116MP0005187_abnormal_penis_morphology0.73665238
117MP0003646_muscle_fatigue0.71096087
118MP0005167_abnormal_blood-brain_barrier0.70978004
119MP0005645_abnormal_hypothalamus_physiol0.69651676
120MP0006036_abnormal_mitochondrial_physio0.68768416
121MP0003122_maternal_imprinting0.68726508
122MP0005448_abnormal_energy_balance0.68373883
123MP0006035_abnormal_mitochondrial_morpho0.65466710
124MP0003953_abnormal_hormone_level0.65264299
125MP0002971_abnormal_brown_adipose0.64990818

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72030497
2Deep venous thrombosis (HP:0002625)4.63384870
3Intrahepatic cholestasis (HP:0001406)4.40008902
4Myokymia (HP:0002411)4.28458076
5Focal motor seizures (HP:0011153)4.22588668
6Exercise-induced myalgia (HP:0003738)4.16602925
7Muscle fiber inclusion bodies (HP:0100299)3.92618588
8Xanthomatosis (HP:0000991)3.84246837
9Hyperlipoproteinemia (HP:0010980)3.68034037
10Nemaline bodies (HP:0003798)3.64704925
11Ketosis (HP:0001946)3.61737712
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.58036787
13Exercise-induced muscle cramps (HP:0003710)3.58024903
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57937528
15Hypobetalipoproteinemia (HP:0003563)3.53674649
16Prolonged partial thromboplastin time (HP:0003645)3.42385654
17Hyperglycinemia (HP:0002154)3.32857323
18Ketoacidosis (HP:0001993)3.31090065
19Hyperammonemia (HP:0001987)3.30702985
20Focal seizures (HP:0007359)3.22389279
21Visual hallucinations (HP:0002367)3.17637470
22Hyperventilation (HP:0002883)3.10651257
23Abnormality of serine family amino acid metabolism (HP:0010894)3.07381878
24Abnormality of glycine metabolism (HP:0010895)3.07381878
25Hyperglycinuria (HP:0003108)3.02488576
26Complement deficiency (HP:0004431)2.93899242
27Hypoglycemic coma (HP:0001325)2.88472202
28Epidermoid cyst (HP:0200040)2.88379805
29Muscle hypertrophy of the lower extremities (HP:0008968)2.81800428
30Hypolipoproteinemia (HP:0010981)2.77263055
31Myoglobinuria (HP:0002913)2.74985375
32Action tremor (HP:0002345)2.74935637
33Subaortic stenosis (HP:0001682)2.73254002
34Abnormality of the left ventricular outflow tract (HP:0011103)2.73254002
35Delayed CNS myelination (HP:0002188)2.68125586
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.64885611
37Limb dystonia (HP:0002451)2.61037610
38Gout (HP:0001997)2.60429616
39Neurofibrillary tangles (HP:0002185)2.60255123
40Hypoalphalipoproteinemia (HP:0003233)2.60066978
41Dysdiadochokinesis (HP:0002075)2.59756299
42Pheochromocytoma (HP:0002666)2.56086713
43Calf muscle hypertrophy (HP:0008981)2.55475399
44Abnormal social behavior (HP:0012433)2.54068756
45Impaired social interactions (HP:0000735)2.54068756
46* Status epilepticus (HP:0002133)2.53557110
47Epileptic encephalopathy (HP:0200134)2.52930574
48Rhabdomyolysis (HP:0003201)2.52085438
49EMG: myopathic abnormalities (HP:0003458)2.50429695
50Hyporeflexia of lower limbs (HP:0002600)2.48697199
51Progressive cerebellar ataxia (HP:0002073)2.48518488
52Torticollis (HP:0000473)2.48085179
53Intention tremor (HP:0002080)2.47749242
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46241788
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45885062
56Postural instability (HP:0002172)2.45613311
57Cerebral inclusion bodies (HP:0100314)2.43678625
58Bundle branch block (HP:0011710)2.42213367
59* Generalized tonic-clonic seizures (HP:0002069)2.42150710
60Rimmed vacuoles (HP:0003805)2.39549790
61Impaired vibration sensation in the lower limbs (HP:0002166)2.38640376
62Poor eye contact (HP:0000817)2.37746683
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.37645852
64Abnormality of the common coagulation pathway (HP:0010990)2.37634093
65Abnormality of the lower motor neuron (HP:0002366)2.36675861
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.34977091
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34977091
68Focal dystonia (HP:0004373)2.34825210
69Atonic seizures (HP:0010819)2.32745750
70Supranuclear gaze palsy (HP:0000605)2.31874856
71Urinary urgency (HP:0000012)2.31331757
72Depression (HP:0000716)2.28083832
73Craniofacial dystonia (HP:0012179)2.27986127
74Abnormality of glycolysis (HP:0004366)2.27265936
75Dysmetria (HP:0001310)2.25396300
76Fetal akinesia sequence (HP:0001989)2.25196849
77EMG: neuropathic changes (HP:0003445)2.24678109
78Fat malabsorption (HP:0002630)2.24058690
79Conjugated hyperbilirubinemia (HP:0002908)2.21693837
80Abnormality of methionine metabolism (HP:0010901)2.21186022
81Sensorimotor neuropathy (HP:0007141)2.20217355
82Skin nodule (HP:0200036)2.19673523
83* Anxiety (HP:0000739)2.19223151
84Tetraplegia (HP:0002445)2.18457214
85Hyperinsulinemic hypoglycemia (HP:0000825)2.16910139
86Hypoglycemic seizures (HP:0002173)2.16473938
87Sudden death (HP:0001699)2.14357859
88Abnormality of binocular vision (HP:0011514)2.13535356
89Diplopia (HP:0000651)2.13535356
90Neonatal onset (HP:0003623)2.13064185
91Neuroendocrine neoplasm (HP:0100634)2.11593926
92Increased serum pyruvate (HP:0003542)2.11180099
93Abnormal eating behavior (HP:0100738)2.11089606
94Scanning speech (HP:0002168)2.08695013
95Cholecystitis (HP:0001082)2.08070399
96Abnormal gallbladder physiology (HP:0012438)2.08070399
97Abnormality of fatty-acid metabolism (HP:0004359)2.07043222
98Hemiplegia (HP:0002301)2.04950333
99Hypercholesterolemia (HP:0003124)2.04370879
100EEG with generalized epileptiform discharges (HP:0011198)2.04149535
101Hypsarrhythmia (HP:0002521)2.04115742
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03963164
103Hemiparesis (HP:0001269)2.03654777
104Spontaneous abortion (HP:0005268)2.02887699
105Joint hemorrhage (HP:0005261)2.02524702
106Metabolic acidosis (HP:0001942)2.02420839
107Myopathic facies (HP:0002058)2.01806093
108Epileptiform EEG discharges (HP:0011182)2.01719122
109* Absence seizures (HP:0002121)2.00647035
110Ankle clonus (HP:0011448)2.00389796
111* Dialeptic seizures (HP:0011146)1.99341083
112Febrile seizures (HP:0002373)1.98996727
113Hyperbilirubinemia (HP:0002904)1.98807341
114Spastic gait (HP:0002064)1.98501646
115Heart block (HP:0012722)1.98215158
116Urinary bladder sphincter dysfunction (HP:0002839)1.97678888
117Abnormality of serum amino acid levels (HP:0003112)1.96888311
118Abnormality of complement system (HP:0005339)1.95226653
119Ventricular fibrillation (HP:0001663)1.95171780
120Dysmetric saccades (HP:0000641)1.91869762
121Abnormality of the intrinsic pathway (HP:0010989)1.91571691
122Confusion (HP:0001289)1.90982745
123Abnormal gallbladder morphology (HP:0012437)1.89570297
124Fair hair (HP:0002286)1.86882178
125Cholelithiasis (HP:0001081)1.86426152
126Turricephaly (HP:0000262)1.85075264
127Increased circulating renin level (HP:0000848)1.83912243
128Impaired vibratory sensation (HP:0002495)1.83612051
129Glomerulonephritis (HP:0000099)1.83120255
130Abnormality of the corticospinal tract (HP:0002492)1.82858754
131Irritability (HP:0000737)1.82692331
132Lethargy (HP:0001254)1.82454880
133Atrioventricular block (HP:0001678)1.81708724
134Cerebral edema (HP:0002181)1.81057671
135Agitation (HP:0000713)1.80936226
136Morphological abnormality of the pyramidal tract (HP:0002062)1.80818273
137Lower limb muscle weakness (HP:0007340)1.77755292
138Difficulty running (HP:0009046)1.77689520
139Hyperkalemia (HP:0002153)1.73402506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.99131968
2OBSCN3.97703526
3NTRK33.53209591
4MAP3K93.09261153
5MAP3K42.85306372
6MARK12.59511585
7MAP2K42.42450334
8DAPK22.22028502
9MINK12.15198839
10MAP3K102.12321060
11PAK62.04436110
12NTRK22.00408799
13MAP2K71.89717979
14KSR21.88474305
15EEF2K1.87365158
16BCKDK1.84463835
17PRKD31.83383112
18NTRK11.81022677
19CAMKK11.76551197
20LMTK21.55639319
21PHKG21.49185082
22PHKG11.49185082
23PINK11.48031497
24STK381.45035769
25CDK51.29946323
26SGK4941.29382263
27SGK2231.29382263
28MAPK111.26914191
29SIK11.25553263
30INSRR1.24032907
31KSR11.22836029
32RPS6KB11.22737626
33MAP3K21.22005076
34PAK31.21035606
35PRKCG1.18586445
36FGFR31.17647307
37OXSR11.16702954
38MAP2K61.15408301
39TRIB31.10697696
40SGK31.09162154
41TYRO31.08732966
42SGK21.07564873
43CAMK1G1.03238637
44RET1.02540843
45TNIK0.99548254
46PRKCH0.99335922
47WNK40.99176366
48LATS20.98351539
49DYRK1A0.97496043
50FGFR20.96679517
51NEK60.95698409
52CAMK2A0.95503787
53WNK30.95248281
54MAP3K130.93822989
55PIK3CA0.92483942
56UHMK10.92350142
57PDK40.92164045
58PDK30.92164045
59SCYL20.90132275
60GRK50.90074988
61STK110.89746111
62NEK10.89176874
63ERBB40.87133196
64MAP3K70.86575155
65PDPK10.86307628
66CAMKK20.81961387
67PRPF4B0.81061495
68CAMK2G0.80051673
69PNCK0.80050239
70STK390.79907107
71MAPK100.79436871
72CSNK1G20.79196069
73PKN10.78881125
74PKN20.78344099
75PRKCZ0.78299754
76RIPK10.77398516
77WNK10.77206708
78PDK10.76779000
79CAMK10.76334590
80TAOK10.76309273
81TNK20.75328599
82SIK20.75278488
83ARAF0.74778993
84DAPK10.74569046
85MAP3K120.74141900
86CAMK2B0.73383138
87ICK0.70703237
88CCNB10.70654256
89SGK10.66686480
90FES0.64530832
91CASK0.63702171
92CSNK1D0.63671177
93CAMK2D0.63465039
94MAP3K10.63201753
95MAPKAPK30.62456722
96CDK190.62341925
97CDK150.61501904
98CDC42BPA0.61443160
99RPS6KA30.61044137
100PLK20.60902888
101CDK140.59718835
102PRKAA20.59353781
103CDK180.59169038
104RAF10.58249129
105PRKAA10.57326467
106MAPK130.57005986
107CAMK40.56759883
108PRKACG0.55767105
109FGFR40.55205669
110CAMK1D0.51665636
111PIK3CG0.50387234
112ERN10.50026007
113PRKG10.49816521
114MAPK40.48786932
115CDK11A0.48097206
116MARK20.47704748
117FRK0.47111268
118EIF2AK10.46847140
119CDK40.46747983
120CSNK1E0.46218498
121FER0.45933058
122SYK0.45844572
123AKT20.45570518
124MAP2K10.45265877
125PRKCE0.45206811
126RIPK40.44531060
127ALK0.44327031
128MAPK120.44232270
129PRKACA0.43849462
130GSK3B0.42198436
131TTN0.40708948
132DYRK1B0.39534878

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.56860332
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01165661
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.00363258
4Arginine biosynthesis_Homo sapiens_hsa002202.63999306
5* Butanoate metabolism_Homo sapiens_hsa006502.21670289
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19781683
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09882379
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06423884
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94638313
10Fatty acid degradation_Homo sapiens_hsa000711.94281968
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93017166
12* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86308169
13Tryptophan metabolism_Homo sapiens_hsa003801.83469582
14Propanoate metabolism_Homo sapiens_hsa006401.77905252
15Bile secretion_Homo sapiens_hsa049761.69631650
16Nicotine addiction_Homo sapiens_hsa050331.68449796
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68144875
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68035421
19Fatty acid metabolism_Homo sapiens_hsa012121.62427492
20GABAergic synapse_Homo sapiens_hsa047271.61231072
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49643285
22Synaptic vesicle cycle_Homo sapiens_hsa047211.42412367
23PPAR signaling pathway_Homo sapiens_hsa033201.42261491
24Complement and coagulation cascades_Homo sapiens_hsa046101.32292182
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30610501
26Peroxisome_Homo sapiens_hsa041461.29701157
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27515346
28beta-Alanine metabolism_Homo sapiens_hsa004101.23677007
29Pyruvate metabolism_Homo sapiens_hsa006201.22633403
30Glutamatergic synapse_Homo sapiens_hsa047241.16199754
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15373995
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14620756
33Circadian entrainment_Homo sapiens_hsa047131.14262141
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09750410
35Morphine addiction_Homo sapiens_hsa050321.09285469
36Sulfur metabolism_Homo sapiens_hsa009201.08586360
37Olfactory transduction_Homo sapiens_hsa047401.08268949
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08213138
39Insulin secretion_Homo sapiens_hsa049111.07630303
40Amphetamine addiction_Homo sapiens_hsa050311.07470416
41Phenylalanine metabolism_Homo sapiens_hsa003601.02076982
42Long-term potentiation_Homo sapiens_hsa047200.99349934
43Histidine metabolism_Homo sapiens_hsa003400.98295585
44Linoleic acid metabolism_Homo sapiens_hsa005910.96245662
45Carbon metabolism_Homo sapiens_hsa012000.96102240
46Salivary secretion_Homo sapiens_hsa049700.95866047
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.93013612
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92986787
49Fatty acid elongation_Homo sapiens_hsa000620.92718901
50Chemical carcinogenesis_Homo sapiens_hsa052040.90864149
51Biosynthesis of amino acids_Homo sapiens_hsa012300.89811958
52Fatty acid biosynthesis_Homo sapiens_hsa000610.88086476
53Dopaminergic synapse_Homo sapiens_hsa047280.87693997
54Gastric acid secretion_Homo sapiens_hsa049710.84895956
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84491198
56Cocaine addiction_Homo sapiens_hsa050300.84027997
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83920493
58Tyrosine metabolism_Homo sapiens_hsa003500.83375541
59Starch and sucrose metabolism_Homo sapiens_hsa005000.82517610
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.78222135
61AMPK signaling pathway_Homo sapiens_hsa041520.75748506
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75287499
63Cholinergic synapse_Homo sapiens_hsa047250.71711818
64ABC transporters_Homo sapiens_hsa020100.70999975
65Renin secretion_Homo sapiens_hsa049240.70354345
66Retinol metabolism_Homo sapiens_hsa008300.69585700
67Glycerolipid metabolism_Homo sapiens_hsa005610.69500834
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69280069
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69189807
70Taste transduction_Homo sapiens_hsa047420.67847150
71Caffeine metabolism_Homo sapiens_hsa002320.67171771
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66448715
73Type II diabetes mellitus_Homo sapiens_hsa049300.66213760
74Fat digestion and absorption_Homo sapiens_hsa049750.65500369
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.62280323
76Insulin signaling pathway_Homo sapiens_hsa049100.61231984
77Circadian rhythm_Homo sapiens_hsa047100.61201904
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60476242
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59502706
80One carbon pool by folate_Homo sapiens_hsa006700.58740274
81Arginine and proline metabolism_Homo sapiens_hsa003300.58140451
82Glucagon signaling pathway_Homo sapiens_hsa049220.57610625
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53703968
84Calcium signaling pathway_Homo sapiens_hsa040200.53506375
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.52670983
86Cardiac muscle contraction_Homo sapiens_hsa042600.52322594
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51952275
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51543180
89Long-term depression_Homo sapiens_hsa047300.51418451
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.51156598
91cAMP signaling pathway_Homo sapiens_hsa040240.49771924
92Thyroid hormone synthesis_Homo sapiens_hsa049180.49522935
93Oxytocin signaling pathway_Homo sapiens_hsa049210.48558724
94Serotonergic synapse_Homo sapiens_hsa047260.48011149
95Vitamin B6 metabolism_Homo sapiens_hsa007500.47821799
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47361602
97Selenocompound metabolism_Homo sapiens_hsa004500.46777649
98Fructose and mannose metabolism_Homo sapiens_hsa000510.46769601
99Lysine degradation_Homo sapiens_hsa003100.46223091
100Steroid biosynthesis_Homo sapiens_hsa001000.45957725
101Prion diseases_Homo sapiens_hsa050200.45734635
102Glioma_Homo sapiens_hsa052140.45565275
103Pentose phosphate pathway_Homo sapiens_hsa000300.43528711
104GnRH signaling pathway_Homo sapiens_hsa049120.41759496
105Gap junction_Homo sapiens_hsa045400.41583621
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38632301
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37604412
108Staphylococcus aureus infection_Homo sapiens_hsa051500.37323709
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36830717
110Pancreatic secretion_Homo sapiens_hsa049720.34719897
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.34219654
112Collecting duct acid secretion_Homo sapiens_hsa049660.33384534
113Estrogen signaling pathway_Homo sapiens_hsa049150.33111497
114Insulin resistance_Homo sapiens_hsa049310.32189014

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