ALDH6A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71347999
2L-phenylalanine catabolic process (GO:0006559)6.71347999
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.45592389
4L-phenylalanine metabolic process (GO:0006558)6.45592389
5aromatic amino acid family catabolic process (GO:0009074)5.98566161
6lysine metabolic process (GO:0006553)5.73496808
7lysine catabolic process (GO:0006554)5.73496808
8glyoxylate metabolic process (GO:0046487)5.62144331
9cysteine metabolic process (GO:0006534)5.49985801
10epoxygenase P450 pathway (GO:0019373)5.45202243
11alpha-linolenic acid metabolic process (GO:0036109)5.40258813
12tryptophan catabolic process (GO:0006569)5.35411742
13indole-containing compound catabolic process (GO:0042436)5.35411742
14indolalkylamine catabolic process (GO:0046218)5.35411742
15omega-hydroxylase P450 pathway (GO:0097267)5.26459418
16sulfur amino acid catabolic process (GO:0000098)5.24104360
17kynurenine metabolic process (GO:0070189)5.20148200
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12247111
19tryptophan metabolic process (GO:0006568)5.07082588
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.04781524
21bile acid biosynthetic process (GO:0006699)5.03693549
22homocysteine metabolic process (GO:0050667)4.85956713
23serine family amino acid catabolic process (GO:0009071)4.82647155
24amino-acid betaine metabolic process (GO:0006577)4.76147419
25urea cycle (GO:0000050)4.56712686
26urea metabolic process (GO:0019627)4.56712686
27short-chain fatty acid metabolic process (GO:0046459)4.55459470
28complement activation, alternative pathway (GO:0006957)4.50663214
29cellular ketone body metabolic process (GO:0046950)4.47833819
30fatty acid beta-oxidation (GO:0006635)4.45190925
31* alpha-amino acid catabolic process (GO:1901606)4.40139362
32acetyl-CoA metabolic process (GO:0006084)4.37902334
33oxidative demethylation (GO:0070989)4.34710659
342-oxoglutarate metabolic process (GO:0006103)4.34459261
35aromatic amino acid family metabolic process (GO:0009072)4.34287555
36aspartate family amino acid catabolic process (GO:0009068)4.30448701
37regulation of triglyceride catabolic process (GO:0010896)4.30425624
38drug transmembrane transport (GO:0006855)4.28984373
39fatty acid oxidation (GO:0019395)4.27948889
40bile acid metabolic process (GO:0008206)4.26708234
41* cellular amino acid catabolic process (GO:0009063)4.23571643
42nitrogen cycle metabolic process (GO:0071941)4.23410077
43lipid oxidation (GO:0034440)4.21285197
44cellular modified amino acid catabolic process (GO:0042219)4.21077066
45high-density lipoprotein particle remodeling (GO:0034375)4.17891532
46urate metabolic process (GO:0046415)4.16047435
47protein carboxylation (GO:0018214)4.14829446
48peptidyl-glutamic acid carboxylation (GO:0017187)4.14829446
49regulation of protein activation cascade (GO:2000257)4.13335903
50ethanol oxidation (GO:0006069)4.10674310
51fatty acid catabolic process (GO:0009062)4.09938433
52negative regulation of fibrinolysis (GO:0051918)4.09595250
53tyrosine metabolic process (GO:0006570)4.09055561
54glutamate metabolic process (GO:0006536)4.02394755
55serine family amino acid metabolic process (GO:0009069)3.99790885
56monocarboxylic acid catabolic process (GO:0072329)3.99189395
57drug catabolic process (GO:0042737)3.98654736
58triglyceride homeostasis (GO:0070328)3.98652740
59acylglycerol homeostasis (GO:0055090)3.98652740
60* organic acid catabolic process (GO:0016054)3.92833671
61* carboxylic acid catabolic process (GO:0046395)3.92833671
62* valine metabolic process (GO:0006573)3.91289899
63regulation of complement activation (GO:0030449)3.90579433
64carnitine metabolic process (GO:0009437)3.90386597
65regulation of fibrinolysis (GO:0051917)3.89382619
66* branched-chain amino acid catabolic process (GO:0009083)3.88666286
67biotin metabolic process (GO:0006768)3.87273205
68ketone body metabolic process (GO:1902224)3.86620171
69coenzyme catabolic process (GO:0009109)3.86555219
70* branched-chain amino acid metabolic process (GO:0009081)3.85696144
71reverse cholesterol transport (GO:0043691)3.82849737
72plasma lipoprotein particle clearance (GO:0034381)3.80980975
73cellular glucuronidation (GO:0052695)3.80683498
74indolalkylamine metabolic process (GO:0006586)3.78641905
75S-adenosylmethionine metabolic process (GO:0046500)3.74547398
76benzene-containing compound metabolic process (GO:0042537)3.73698985
77plasma lipoprotein particle remodeling (GO:0034369)3.72469179
78protein-lipid complex remodeling (GO:0034368)3.72469179
79macromolecular complex remodeling (GO:0034367)3.72469179
80positive regulation of fatty acid beta-oxidation (GO:0032000)3.72347758
81dicarboxylic acid biosynthetic process (GO:0043650)3.72155431
82serine family amino acid biosynthetic process (GO:0009070)3.66129125
83glycine metabolic process (GO:0006544)3.65788072
84regulation of cholesterol esterification (GO:0010872)3.63149444
85cellular biogenic amine catabolic process (GO:0042402)3.62669409
86amine catabolic process (GO:0009310)3.62669409
87negative regulation of sterol transport (GO:0032372)3.61110372
88negative regulation of cholesterol transport (GO:0032375)3.61110372
89fatty acid transmembrane transport (GO:1902001)3.60701898
90ethanol metabolic process (GO:0006067)3.57952519
91exogenous drug catabolic process (GO:0042738)3.57201684
92tricarboxylic acid metabolic process (GO:0072350)3.56254308
93drug transport (GO:0015893)3.53155720
94positive regulation of lipid catabolic process (GO:0050996)3.52336792
95regulation of cholesterol homeostasis (GO:2000188)3.52100374
96phospholipid homeostasis (GO:0055091)3.51563611
97phenylpropanoid metabolic process (GO:0009698)3.46679086
98uronic acid metabolic process (GO:0006063)3.45400755
99glucuronate metabolic process (GO:0019585)3.45400755
100response to mercury ion (GO:0046689)3.41388951
101positive regulation of fatty acid oxidation (GO:0046321)3.40090175
102bile acid and bile salt transport (GO:0015721)3.39381728
103drug metabolic process (GO:0017144)3.38177718
104phospholipid efflux (GO:0033700)3.37435050
105C4-dicarboxylate transport (GO:0015740)3.33277739
106regulation of cholesterol metabolic process (GO:0090181)3.32295106
107* small molecule catabolic process (GO:0044282)3.31355382
108water-soluble vitamin biosynthetic process (GO:0042364)3.26404508
109negative regulation of lipase activity (GO:0060192)3.15064014
110gamma-aminobutyric acid transport (GO:0015812)3.11462770
111blood coagulation, intrinsic pathway (GO:0007597)3.09428417
112heme transport (GO:0015886)3.08704820
113amino acid salvage (GO:0043102)3.07933826
114L-methionine salvage (GO:0071267)3.07933826
115L-methionine biosynthetic process (GO:0071265)3.07933826
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04210719
117arginine metabolic process (GO:0006525)3.03271822
118alkaloid metabolic process (GO:0009820)2.99968635
119sodium-independent organic anion transport (GO:0043252)2.95340960
120aldehyde catabolic process (GO:0046185)2.94942218
121xenobiotic catabolic process (GO:0042178)2.92226788
122flavonoid metabolic process (GO:0009812)2.89514208
123cholesterol efflux (GO:0033344)2.74548829
124behavioral response to nicotine (GO:0035095)2.71346736
125axon ensheathment in central nervous system (GO:0032291)2.67568468
126central nervous system myelination (GO:0022010)2.67568468
127indole-containing compound metabolic process (GO:0042430)2.66802348
128arginine catabolic process (GO:0006527)2.61702079
129positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.60238482
130iron coordination entity transport (GO:1901678)2.56395329
131neurotransmitter catabolic process (GO:0042135)2.55874864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.36973837
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.88490333
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.30494505
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.83761395
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.32703168
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60850569
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.87082614
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72069389
9EZH2_22144423_ChIP-Seq_EOC_Human3.36144392
10GBX2_23144817_ChIP-Seq_PC3_Human3.15585349
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.13405807
12* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.91171832
13CLOCK_20551151_ChIP-Seq_293T_Human2.30678839
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27244003
15IGF1R_20145208_ChIP-Seq_DFB_Human2.22003145
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19524214
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13017574
18ZNF274_21170338_ChIP-Seq_K562_Hela2.09549920
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09009260
20VDR_22108803_ChIP-Seq_LS180_Human2.08588357
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08544904
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02151694
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1967356
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97301430
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86534801
26TAF15_26573619_Chip-Seq_HEK293_Human1.84967556
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84854469
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81418618
29P300_19829295_ChIP-Seq_ESCs_Human1.78292941
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74118606
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65784417
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64610943
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54456640
34SMAD4_21799915_ChIP-Seq_A2780_Human1.53445289
35REST_21632747_ChIP-Seq_MESCs_Mouse1.53262921
36ER_23166858_ChIP-Seq_MCF-7_Human1.51991221
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51643651
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47288813
39FUS_26573619_Chip-Seq_HEK293_Human1.45729766
40GATA1_22025678_ChIP-Seq_K562_Human1.44109682
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44077811
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.43790659
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41739289
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40469809
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.39738392
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39455790
47STAT3_23295773_ChIP-Seq_U87_Human1.38815314
48AR_25329375_ChIP-Seq_VCAP_Human1.35083938
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34690719
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34051551
51TCF4_23295773_ChIP-Seq_U87_Human1.33452346
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32465997
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31715018
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29726590
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27251013
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27208939
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26468066
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.25753355
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.23027933
60TCF4_22108803_ChIP-Seq_LS180_Human1.22874453
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20869015
62EWS_26573619_Chip-Seq_HEK293_Human1.20560702
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19402609
64SOX2_19829295_ChIP-Seq_ESCs_Human1.17119890
65NANOG_19829295_ChIP-Seq_ESCs_Human1.17119890
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16034439
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15525037
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14368574
69AR_21572438_ChIP-Seq_LNCaP_Human1.14191006
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13742332
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13692966
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13134958
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.11589777
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11468081
75CBP_20019798_ChIP-Seq_JUKART_Human1.11468081
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10829739
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.10595745
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10423182
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.10045321
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.09841548
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09633789
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.09459992
83DROSHA_22980978_ChIP-Seq_HELA_Human1.09451060
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.09300980
85HTT_18923047_ChIP-ChIP_STHdh_Human1.08702660
86RUNX2_22187159_ChIP-Seq_PCA_Human1.08225001
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.07948076
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07833618
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07308351
90* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07214032
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06839333
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.06827860
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.04974892
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04525365
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.04205599
96P53_22387025_ChIP-Seq_ESCs_Mouse1.03849004
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03812485
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02339867
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02339867
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01806134
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98949265
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98714757
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98255014
104IRF1_19129219_ChIP-ChIP_H3396_Human0.98017481
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97812705
106RNF2_27304074_Chip-Seq_NSC_Mouse0.97682453
107CRX_20693478_ChIP-Seq_RETINA_Mouse0.97627321
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97593830
109ZNF263_19887448_ChIP-Seq_K562_Human0.96915488
110EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96591517
111RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96591517
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96330931
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.96162858
114GATA4_25053715_ChIP-Seq_YYC3_Human0.95955243
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95228200
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91975101
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90241796
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90241796
119RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90192074
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.88418978
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88398828
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84830825
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83200771
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82032920
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81992322
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.81012428
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.81012428
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.78421140
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77567750
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76679378
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75909612
132IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74842079
133TRIM28_21343339_ChIP-Seq_HEK293_Human0.74194933
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72183362
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71994625
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71110359
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71012751
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.70112890
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70061139
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66887628
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65070969
142EGR1_19032775_ChIP-ChIP_M12_Human0.63813400
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.63703065
144LXR_22292898_ChIP-Seq_THP-1_Human0.63478855
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.61936271
146ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61665645
147CEBPB_22108803_ChIP-Seq_LS180_Human0.61456040
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.61343421
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.60993287
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60203850
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59797790
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59538095
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59483403
154BCAT_22108803_ChIP-Seq_LS180_Human0.58716747
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57298002
156* CBP_21632823_ChIP-Seq_H3396_Human0.56949452
157SOX2_20726797_ChIP-Seq_SW620_Human0.56653438
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55125785
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55099017
160SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.54648322
161GATA1_19941826_ChIP-Seq_K562_Human0.53840688
162AR_20517297_ChIP-Seq_VCAP_Human0.53634448
163GATA2_19941826_ChIP-Seq_K562_Human0.53619501
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53603346
165GATA3_24758297_ChIP-Seq_MCF-7_Human0.53396174
166MYC_19915707_ChIP-ChIP_AK7_Human0.50873942
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.50503254
168RARA_24833708_ChIP-Seq_LIVER_Mouse0.50150742
169CDX2_22108803_ChIP-Seq_LS180_Human0.49433268
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49015488
171STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48721265
172SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46698631
173GATA6_25053715_ChIP-Seq_YYC3_Human0.46562587
174KAP1_22055183_ChIP-Seq_ESCs_Mouse0.46145059
175RACK7_27058665_Chip-Seq_MCF-7_Human0.45567561
176RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.45567038
177TAF2_19829295_ChIP-Seq_ESCs_Human0.44785264
178GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.44149769
179STAT1_17558387_ChIP-Seq_HELA_Human0.44062123
180PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43726732
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.43525825
182ERG_20517297_ChIP-Seq_VCAP_Human0.43120853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.35758590
2MP0005360_urolithiasis7.30683436
3MP0005365_abnormal_bile_salt5.53683316
4MP0005085_abnormal_gallbladder_physiolo5.37848974
5MP0008875_abnormal_xenobiotic_pharmacok4.52745604
6MP0003806_abnormal_nucleotide_metabolis3.58015499
7MP0003252_abnormal_bile_duct3.41609185
8MP0010329_abnormal_lipoprotein_level3.38464727
9MP0005332_abnormal_amino_acid3.35244744
10MP0003195_calcinosis2.97129298
11MP0009840_abnormal_foam_cell2.55428300
12MP0004019_abnormal_vitamin_homeostasis2.53287241
13MP0005083_abnormal_biliary_tract2.48291024
14MP0001666_abnormal_nutrient_absorption2.41875269
15MP0003191_abnormal_cellular_cholesterol2.37030443
16MP0005670_abnormal_white_adipose2.35373412
17MP0003880_abnormal_central_pattern2.29355486
18MP0002118_abnormal_lipid_homeostasis2.22669195
19MP0000609_abnormal_liver_physiology1.98351707
20MP0002138_abnormal_hepatobiliary_system1.95130941
21MP0009643_abnormal_urine_homeostasis1.86874063
22MP0005319_abnormal_enzyme/_coenzyme1.84625412
23MP0004130_abnormal_muscle_cell1.83856121
24MP0009745_abnormal_behavioral_response1.82119324
25MP0001486_abnormal_startle_reflex1.81277755
26MP0002272_abnormal_nervous_system1.75523166
27MP0002064_seizures1.74743980
28MP0005584_abnormal_enzyme/coenzyme_acti1.73951731
29MP0005551_abnormal_eye_electrophysiolog1.67490899
30MP0004043_abnormal_pH_regulation1.65614748
31MP0002638_abnormal_pupillary_reflex1.63651834
32MP0004270_analgesia1.62303903
33MP0005666_abnormal_adipose_tissue1.60862561
34MP0001968_abnormal_touch/_nociception1.60811355
35MP0001764_abnormal_homeostasis1.59063495
36MP0002736_abnormal_nociception_after1.56708806
37MP0003186_abnormal_redox_activity1.55726390
38MP0009046_muscle_twitch1.52930617
39MP0005646_abnormal_pituitary_gland1.52095088
40MP0005423_abnormal_somatic_nervous1.50854798
41MP0002837_dystrophic_cardiac_calcinosis1.49468566
42MP0001984_abnormal_olfaction1.48216763
43MP0003136_yellow_coat_color1.46139970
44MP0004859_abnormal_synaptic_plasticity1.42322004
45MP0003635_abnormal_synaptic_transmissio1.40197302
46MP0001485_abnormal_pinna_reflex1.39260189
47MP0003868_abnormal_feces_composition1.37564735
48MP0002734_abnormal_mechanical_nocicepti1.31325930
49MP0002971_abnormal_brown_adipose1.28886877
50MP0002063_abnormal_learning/memory/cond1.28759085
51MP0003705_abnormal_hypodermis_morpholog1.28475537
52MP0005636_abnormal_mineral_homeostasis1.28034937
53MP0006036_abnormal_mitochondrial_physio1.27732928
54MP0004885_abnormal_endolymph1.27278099
55MP0001756_abnormal_urination1.26894470
56MP0002572_abnormal_emotion/affect_behav1.26707146
57MP0001501_abnormal_sleep_pattern1.25123922
58MP0005451_abnormal_body_composition1.24051459
59MP0004215_abnormal_myocardial_fiber1.22698140
60MP0003879_abnormal_hair_cell1.21280792
61MP0005535_abnormal_body_temperature1.19309687
62MP0006292_abnormal_olfactory_placode1.16192038
63MP0006276_abnormal_autonomic_nervous1.15951931
64MP0002876_abnormal_thyroid_physiology1.15116052
65MP0002735_abnormal_chemical_nociception1.14126775
66MP0004145_abnormal_muscle_electrophysio1.12662952
67MP0001661_extended_life_span1.10160251
68MP0002102_abnormal_ear_morphology1.09948662
69MP0004142_abnormal_muscle_tone1.08171191
70MP0001986_abnormal_taste_sensitivity1.08085057
71MP0002557_abnormal_social/conspecific_i1.07005682
72MP0005647_abnormal_sex_gland1.06467677
73MP0005386_behavior/neurological_phenoty1.03797432
74MP0004924_abnormal_behavior1.03797432
75MP0002254_reproductive_system_inflammat1.03583971
76MP0005187_abnormal_penis_morphology1.02714223
77MP0002078_abnormal_glucose_homeostasis1.02679258
78MP0005334_abnormal_fat_pad1.01828620
79MP0000566_synostosis1.01041466
80MP0000604_amyloidosis1.00797588
81MP0000598_abnormal_liver_morphology1.00283553
82MP0004185_abnormal_adipocyte_glucose0.97642386
83MP0010386_abnormal_urinary_bladder0.97298061
84MP0003633_abnormal_nervous_system0.97187238
85MP0005253_abnormal_eye_physiology0.97110153
86MP0002067_abnormal_sensory_capabilities0.96273575
87MP0002234_abnormal_pharynx_morphology0.96044300
88MP0003690_abnormal_glial_cell0.95592293
89MP0005375_adipose_tissue_phenotype0.93532732
90MP0002136_abnormal_kidney_physiology0.92730299
91MP0003137_abnormal_impulse_conducting0.92716144
92MP0003656_abnormal_erythrocyte_physiolo0.91141350
93MP0000778_abnormal_nervous_system0.90421051
94MP0009764_decreased_sensitivity_to0.90359511
95MP0001765_abnormal_ion_homeostasis0.89387984
96MP0003329_amyloid_beta_deposits0.88054903
97MP0003011_delayed_dark_adaptation0.86676849
98MP0003122_maternal_imprinting0.86613953
99MP0001970_abnormal_pain_threshold0.86573911
100MP0009642_abnormal_blood_homeostasis0.85643885
101MP0005167_abnormal_blood-brain_barrier0.85102288
102MP0001440_abnormal_grooming_behavior0.84591002
103MP0009697_abnormal_copulation0.83686264
104MP0005084_abnormal_gallbladder_morpholo0.82626960
105MP0002938_white_spotting0.80992267
106MP0003646_muscle_fatigue0.80850030
107MP0002733_abnormal_thermal_nociception0.80366111
108MP0003631_nervous_system_phenotype0.79434839
109MP0009763_increased_sensitivity_to0.79411988
110MP0000631_abnormal_neuroendocrine_gland0.77529350
111MP0001502_abnormal_circadian_rhythm0.77248717
112MP0003787_abnormal_imprinting0.77048803
113MP0001963_abnormal_hearing_physiology0.76500942
114MP0002090_abnormal_vision0.76428984
115MP0002229_neurodegeneration0.75880719
116MP0005377_hearing/vestibular/ear_phenot0.75765602
117MP0003878_abnormal_ear_physiology0.75765602
118MP0009115_abnormal_fat_cell0.75338538
119MP0000230_abnormal_systemic_arterial0.74469370
120MP0005376_homeostasis/metabolism_phenot0.74354755
121MP0001905_abnormal_dopamine_level0.74076441
122MP0005058_abnormal_lysosome_morphology0.73552567
123MP0003632_abnormal_nervous_system0.72838096
124MP0005448_abnormal_energy_balance0.72577342
125MP0004133_heterotaxia0.72439273
126MP0000026_abnormal_inner_ear0.71919757
127MP0004742_abnormal_vestibular_system0.71583419
128MP0002909_abnormal_adrenal_gland0.71311896
129MP0005220_abnormal_exocrine_pancreas0.69713033
130MP0008469_abnormal_protein_level0.69168885
131MP0006035_abnormal_mitochondrial_morpho0.65652838
132MP0005266_abnormal_metabolism0.64785008
133MP0010368_abnormal_lymphatic_system0.62759286
134MP0002168_other_aberrant_phenotype0.61066975
135MP0003953_abnormal_hormone_level0.60379120
136MP0005330_cardiomyopathy0.59718815
137MP0003959_abnormal_lean_body0.59662625
138MP0008961_abnormal_basal_metabolism0.58846294
139MP0009765_abnormal_xenobiotic_induced0.57781499
140MP0005408_hypopigmentation0.57088224
141MP0002970_abnormal_white_adipose0.57006309
142MP0009780_abnormal_chondrocyte_physiolo0.52154317
143MP0003638_abnormal_response/metabolism_0.49330932
144MP0002796_impaired_skin_barrier0.48895121
145MP0002269_muscular_atrophy0.47535879
146MP0009384_cardiac_valve_regurgitation0.44994680
147MP0005395_other_phenotype0.44387797
148MP0000538_abnormal_urinary_bladder0.43943349
149MP0003075_altered_response_to0.43151407
150MP0002928_abnormal_bile_duct0.41440236
151MP0006138_congestive_heart_failure0.40699692
152MP0005452_abnormal_adipose_tissue0.40478715
153MP0004147_increased_porphyrin_level0.40079461
154MP0000639_abnormal_adrenal_gland0.39119238
155MP0000003_abnormal_adipose_tissue0.38910090
156MP0000013_abnormal_adipose_tissue0.38695040
157MP0008874_decreased_physiological_sensi0.38482754
158MP0002332_abnormal_exercise_endurance0.38171135
159MP0008438_abnormal_cutaneous_collagen0.38020767
160MP0002135_abnormal_kidney_morphology0.36940506
161MP0009672_abnormal_birth_weight0.36933831
162MP0003724_increased_susceptibility_to0.36261565
163MP0005620_abnormal_muscle_contractility0.35882516
164MP0008872_abnormal_physiological_respon0.35376820
165MP0004782_abnormal_surfactant_physiolog0.35213111

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.93350287
2Intrahepatic cholestasis (HP:0001406)5.66395778
3Hyperglycinuria (HP:0003108)5.53750928
4Deep venous thrombosis (HP:0002625)5.45362954
5Xanthomatosis (HP:0000991)5.38526027
6Abnormality of glycine metabolism (HP:0010895)5.11583175
7Abnormality of serine family amino acid metabolism (HP:0010894)5.11583175
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.94671786
9Ketosis (HP:0001946)4.91771119
10Hyperglycinemia (HP:0002154)4.81135460
11Hyperammonemia (HP:0001987)4.79866046
12Hyperlipoproteinemia (HP:0010980)4.56457578
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56229310
14Prolonged partial thromboplastin time (HP:0003645)4.48320114
15Hypobetalipoproteinemia (HP:0003563)4.40487249
16Complement deficiency (HP:0004431)4.38616220
17Ketoacidosis (HP:0001993)4.27908901
18Abnormality of fatty-acid metabolism (HP:0004359)4.26635904
19Hypoglycemic coma (HP:0001325)4.22538995
20Gout (HP:0001997)3.98799998
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88787779
22Epidermoid cyst (HP:0200040)3.83043777
23Hypolipoproteinemia (HP:0010981)3.79391035
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.77493586
25Hypoalphalipoproteinemia (HP:0003233)3.75187917
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57808286
27Hypomagnesemia (HP:0002917)3.56980810
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51446481
29Abnormality of purine metabolism (HP:0004352)3.50770112
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.37316156
31Dicarboxylic aciduria (HP:0003215)3.37316156
32Joint hemorrhage (HP:0005261)3.33187800
33Fat malabsorption (HP:0002630)3.28631836
34Abnormality of the common coagulation pathway (HP:0010990)3.26464921
35Generalized aminoaciduria (HP:0002909)3.25752300
36Delayed CNS myelination (HP:0002188)3.25584001
37Abnormality of methionine metabolism (HP:0010901)3.22093583
38Abnormality of serum amino acid levels (HP:0003112)3.20102111
39Abnormality of nucleobase metabolism (HP:0010932)3.20028012
40Proximal tubulopathy (HP:0000114)3.13697369
41Focal motor seizures (HP:0011153)3.11984717
42Metabolic acidosis (HP:0001942)3.08911661
43Abnormality of complement system (HP:0005339)3.02873559
44Increased purine levels (HP:0004368)3.00422472
45Hyperuricemia (HP:0002149)3.00422472
46Hypercholesterolemia (HP:0003124)2.94018154
47Lethargy (HP:0001254)2.91609134
48Abnormality of the intrinsic pathway (HP:0010989)2.88608381
49Polyuria (HP:0000103)2.88530765
50Abnormality of magnesium homeostasis (HP:0004921)2.79482847
51Hydroxyprolinuria (HP:0003080)2.79016710
52Abnormality of proline metabolism (HP:0010907)2.79016710
53Polydipsia (HP:0001959)2.75383516
54Abnormal drinking behavior (HP:0030082)2.75383516
55Hyperventilation (HP:0002883)2.73638186
56Conjugated hyperbilirubinemia (HP:0002908)2.72703896
57Hyperbilirubinemia (HP:0002904)2.71070598
58Hyperalaninemia (HP:0003348)2.66459920
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66459920
60Abnormality of alanine metabolism (HP:0010916)2.66459920
61Alkalosis (HP:0001948)2.59267603
62Hyperaldosteronism (HP:0000859)2.58711041
63Abnormality of pyrimidine metabolism (HP:0004353)2.58543811
64Cerebral edema (HP:0002181)2.57767073
65Vascular calcification (HP:0004934)2.57127666
66Vomiting (HP:0002013)2.55027733
67Skin nodule (HP:0200036)2.53929240
68Myocardial infarction (HP:0001658)2.51174571
69Steatorrhea (HP:0002570)2.49884073
70Hepatocellular carcinoma (HP:0001402)2.48302622
71Myokymia (HP:0002411)2.47089127
72Myoglobinuria (HP:0002913)2.45797364
73Abnormality of renin-angiotensin system (HP:0000847)2.42908548
74Hypoglycemic seizures (HP:0002173)2.42258933
75Hypothermia (HP:0002045)2.39654409
76Abnormality of renal excretion (HP:0011036)2.38825250
77Pancreatic cysts (HP:0001737)2.38544779
78Pancreatitis (HP:0001733)2.35980388
79Focal seizures (HP:0007359)2.34837990
80Abnormality of urine glucose concentration (HP:0011016)2.33603297
81Glycosuria (HP:0003076)2.33603297
82Renal salt wasting (HP:0000127)2.31272405
83Cardiovascular calcification (HP:0011915)2.31024400
84Sensorimotor neuropathy (HP:0007141)2.29725230
85Irritability (HP:0000737)2.29345103
86Hypokalemia (HP:0002900)2.28130358
87Neonatal onset (HP:0003623)2.26468488
88Enlarged kidneys (HP:0000105)2.25510154
89Malnutrition (HP:0004395)2.22354951
90Hypokalemic alkalosis (HP:0001949)2.20909926
91Late onset (HP:0003584)2.20175492
92Spastic diplegia (HP:0001264)2.19554310
93Hyperphosphaturia (HP:0003109)2.17135119
94Abnormality of the renal cortex (HP:0011035)2.12908607
95Nausea (HP:0002018)2.11982940
96Hemiparesis (HP:0001269)2.11775789
97Systemic lupus erythematosus (HP:0002725)2.11681782
98Febrile seizures (HP:0002373)2.06731623
99Increased circulating renin level (HP:0000848)2.05719789
100Hypertriglyceridemia (HP:0002155)2.05180177
101Abnormal biliary tract physiology (HP:0012439)2.03690589
102Bile duct proliferation (HP:0001408)2.03690589
103Abnormality of chloride homeostasis (HP:0011422)2.03004043
104Abnormal gallbladder morphology (HP:0012437)2.02821380
105Cholelithiasis (HP:0001081)2.01549650
106Fair hair (HP:0002286)2.00637160
107Renal cortical cysts (HP:0000803)2.00115222
108Abnormal cartilage morphology (HP:0002763)1.99843167
109Hyperinsulinemic hypoglycemia (HP:0000825)1.99164334
110Rickets (HP:0002748)1.98621598
111Methylmalonic acidemia (HP:0002912)1.96026829
112Brushfield spots (HP:0001088)1.95136790
113Acute encephalopathy (HP:0006846)1.94975521
114Tubular atrophy (HP:0000092)1.94611786
115Spontaneous abortion (HP:0005268)1.93512005
116Methylmalonic aciduria (HP:0012120)1.92166017
117Hyperactive renin-angiotensin system (HP:0000841)1.90119892
118True hermaphroditism (HP:0010459)1.89375056
119Medial flaring of the eyebrow (HP:0010747)1.86590405
120Chronic hepatic failure (HP:0100626)1.86195099
121Potter facies (HP:0002009)1.85897996
122Facial shape deformation (HP:0011334)1.85897996
123Generalized tonic-clonic seizures (HP:0002069)1.85415675
124Abnormal enzyme/coenzyme activity (HP:0012379)1.85011517
125Esophageal varix (HP:0002040)1.84876419
126Pancreatic fibrosis (HP:0100732)1.84342903
127Metabolic alkalosis (HP:0200114)1.82710725
128Status epilepticus (HP:0002133)1.82666434
129Hyperglycemia (HP:0003074)1.82314893
130Nephrolithiasis (HP:0000787)1.82290284
131Large for gestational age (HP:0001520)1.81929351
132Mitral stenosis (HP:0001718)1.81467926
133Progressive cerebellar ataxia (HP:0002073)1.81200035
134Congenital stationary night blindness (HP:0007642)1.80706836
135Epileptic encephalopathy (HP:0200134)1.80634867
136Increased serum pyruvate (HP:0003542)1.80116711
137Abnormality of potassium homeostasis (HP:0011042)1.79795860
138Abnormal urine output (HP:0012590)1.79347577
139Rhabdomyolysis (HP:0003201)1.79007669
140Hemorrhage of the eye (HP:0011885)1.78838558
141Gait imbalance (HP:0002141)1.78313580
142Nephrogenic diabetes insipidus (HP:0009806)1.78285197
143Dialeptic seizures (HP:0011146)1.77244438
144Decreased central vision (HP:0007663)1.76294487
145Abnormality of vitamin metabolism (HP:0100508)1.73808189
146Opisthotonus (HP:0002179)1.73198538
147Glomerulonephritis (HP:0000099)1.72676449
148Amyloidosis (HP:0011034)1.72418706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.93867239
2SIK13.81498975
3ERN13.11122107
4WNK43.09305239
5CASK2.92389442
6TRIB32.88709220
7FGFR42.84829381
8PDK32.61096985
9PDK42.61096985
10INSRR2.56583388
11WNK32.45572912
12OXSR12.41402045
13NTRK32.25795826
14BMPR1B2.14170398
15MARK12.09843475
16PKN22.03955378
17CAMK1D1.84660081
18ACVR1B1.83351337
19MST1R1.82965610
20GRK11.74889704
21PINK11.74370457
22PDK21.73452176
23STK391.73369501
24MAP4K21.71568541
25MAPK131.70075411
26TNIK1.65902510
27LMTK21.55722644
28NTRK21.55188056
29MAP2K41.53478007
30STK38L1.48459521
31ERBB41.47785955
32LATS11.41600225
33ADRBK21.40584026
34FRK1.40414064
35PNCK1.39258326
36PRKAA21.33918964
37PRKCG1.33442544
38NUAK11.30062308
39FLT31.29628793
40FGFR21.28020231
41MAPK111.27406137
42MAP3K41.26539945
43TAOK31.26100830
44PAK61.25412406
45PIK3CG1.23661375
46CAMK1G1.22504691
47MAP3K71.21906681
48PLK21.19506379
49TIE11.15215265
50PHKG21.13687393
51PHKG11.13687393
52SGK2231.11670987
53SGK4941.11670987
54AKT31.09657567
55MKNK21.07243673
56NEK91.04504836
57PTK61.04403913
58SGK31.02662183
59ZAK0.99058807
60RIPK10.97393796
61PRKAA10.97160023
62CSNK1G20.96276295
63PRKCE0.90244901
64CSNK1G10.89693211
65DAPK20.88097947
66MAP2K30.87916739
67SGK20.87877732
68JAK20.87676524
69EPHB10.87448011
70MET0.86266169
71TRIM280.85477254
72NEK10.84373264
73CAMK10.84263378
74MINK10.84088530
75CAMK2A0.84074985
76PKN10.82454049
77MUSK0.80815818
78MAPK120.80804306
79ABL20.79921992
80OBSCN0.79387675
81PDPK10.78820924
82WEE10.78319307
83PIK3CA0.76065931
84MYLK0.75184436
85TTN0.74585006
86TGFBR20.73806169
87UHMK10.73538973
88CAMK2B0.72863015
89CAMK2D0.72078495
90MAP3K30.72067885
91CAMKK20.71907485
92GSK3A0.71306195
93DYRK20.71149774
94CSNK1G30.70035308
95JAK10.69065312
96PRKACG0.68099043
97TLK10.67198837
98CSNK1A1L0.66617489
99STK380.65883450
100PRKACA0.64417961
101PRKCZ0.63911131
102GRK50.63781670
103FGFR30.62932398
104TNK20.62849458
105TYK20.62635053
106MAPKAPK50.62399015
107MAPKAPK30.61495377
108NLK0.59450336
109DYRK1A0.58111697
110CSNK1A10.57714269
111PDK10.56880957
112PRKG10.56577042
113CDK50.54710854
114IRAK20.54083219
115MAP2K10.53531833
116PDGFRA0.53471487
117PLK30.52279339
118BRSK20.50454213
119RET0.49575740
120CAMK2G0.49025658
121PAK30.48328866
122CSNK1D0.47685527
123MAP2K70.47303330
124KDR0.47140093
125CAMKK10.46782880
126STK110.46699236
127FER0.46483530
128PRKCA0.45627340
129MAPK40.44642649
130ADRBK10.43288068
131RPS6KA30.43054506
132ERBB20.42825435
133PRKACB0.42527816
134ERBB30.42032614
135ROCK10.41834832
136WNK10.41673715
137PRKCH0.41128931
138MAP2K60.41022936
139PRKD30.40757442
140CDK60.40254958
141MAPK150.39512725
142EPHA40.39484010
143PTK20.39230072
144PBK0.39225024
145IGF1R0.35936740
146PRKD10.35017942
147IRAK10.34666312
148MAPK70.32821274
149IRAK30.32652324
150MTOR0.32285434
151DYRK1B0.31834148
152MAP3K60.30932013
153EPHA30.30267956
154MAP3K20.27945250
155GRK60.27934542
156FGFR10.26196946
157LRRK20.26052442
158PRKCQ0.25117246
159CAMK40.24126658
160TAOK20.23474318
161SGK10.23208503

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58994933
2Nitrogen metabolism_Homo sapiens_hsa009103.39330023
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05687552
4* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.98920700
5Fatty acid degradation_Homo sapiens_hsa000712.96891364
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91550319
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.88296244
8* Propanoate metabolism_Homo sapiens_hsa006402.78825257
9Arginine biosynthesis_Homo sapiens_hsa002202.61176017
10Tryptophan metabolism_Homo sapiens_hsa003802.57443923
11Butanoate metabolism_Homo sapiens_hsa006502.56111097
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55169459
13Fatty acid metabolism_Homo sapiens_hsa012122.36509095
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33499457
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28546864
16Peroxisome_Homo sapiens_hsa041462.21397854
17PPAR signaling pathway_Homo sapiens_hsa033202.19671372
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19298302
19Complement and coagulation cascades_Homo sapiens_hsa046102.00432263
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97604586
21Pyruvate metabolism_Homo sapiens_hsa006201.83957460
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82828741
23* beta-Alanine metabolism_Homo sapiens_hsa004101.77317008
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71156671
25Chemical carcinogenesis_Homo sapiens_hsa052041.58512818
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58144189
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57069904
28Histidine metabolism_Homo sapiens_hsa003401.55998564
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54262539
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.51484573
31Sulfur metabolism_Homo sapiens_hsa009201.51113688
32* Carbon metabolism_Homo sapiens_hsa012001.48523758
33Fatty acid elongation_Homo sapiens_hsa000621.46215325
34Phenylalanine metabolism_Homo sapiens_hsa003601.44796288
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44440622
36Bile secretion_Homo sapiens_hsa049761.43638969
37Caffeine metabolism_Homo sapiens_hsa002321.40200252
38Starch and sucrose metabolism_Homo sapiens_hsa005001.35113709
39Retinol metabolism_Homo sapiens_hsa008301.34406072
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.32632447
41Selenocompound metabolism_Homo sapiens_hsa004501.26761071
42Biosynthesis of amino acids_Homo sapiens_hsa012301.24367824
43Tyrosine metabolism_Homo sapiens_hsa003501.23916894
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23458657
45Staphylococcus aureus infection_Homo sapiens_hsa051501.17655371
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.16504281
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14469721
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.12418104
49Fat digestion and absorption_Homo sapiens_hsa049751.09242982
50Fatty acid biosynthesis_Homo sapiens_hsa000611.08876034
51Glycerolipid metabolism_Homo sapiens_hsa005611.05595780
52Nicotine addiction_Homo sapiens_hsa050331.04039203
53ABC transporters_Homo sapiens_hsa020101.03328544
54Arginine and proline metabolism_Homo sapiens_hsa003301.00904700
55Folate biosynthesis_Homo sapiens_hsa007900.95698013
56Vitamin digestion and absorption_Homo sapiens_hsa049770.95634471
57Lysine degradation_Homo sapiens_hsa003100.93131466
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89396033
59Steroid biosynthesis_Homo sapiens_hsa001000.82611403
60Vitamin B6 metabolism_Homo sapiens_hsa007500.80301992
61Sulfur relay system_Homo sapiens_hsa041220.76386611
62Glutathione metabolism_Homo sapiens_hsa004800.74104694
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.71836624
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69875100
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69091996
66Insulin secretion_Homo sapiens_hsa049110.68520927
67Phototransduction_Homo sapiens_hsa047440.65054366
68GABAergic synapse_Homo sapiens_hsa047270.64434448
69Pentose phosphate pathway_Homo sapiens_hsa000300.60830250
70Circadian entrainment_Homo sapiens_hsa047130.52626871
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.50519477
72Cardiac muscle contraction_Homo sapiens_hsa042600.49920197
73Glutamatergic synapse_Homo sapiens_hsa047240.49013200
74* Metabolic pathways_Homo sapiens_hsa011000.48197394
75Amphetamine addiction_Homo sapiens_hsa050310.48071474
76Serotonergic synapse_Homo sapiens_hsa047260.47725827
77Ether lipid metabolism_Homo sapiens_hsa005650.45640035
78Insulin resistance_Homo sapiens_hsa049310.43394207
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42920359
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42395573
81Fructose and mannose metabolism_Homo sapiens_hsa000510.42085203
82Morphine addiction_Homo sapiens_hsa050320.41686543
83Protein export_Homo sapiens_hsa030600.38118674
84Cocaine addiction_Homo sapiens_hsa050300.37002750
85Gastric acid secretion_Homo sapiens_hsa049710.36988570
86Parkinsons disease_Homo sapiens_hsa050120.36063387
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33136674
88Taste transduction_Homo sapiens_hsa047420.32666590
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31540078
90AMPK signaling pathway_Homo sapiens_hsa041520.30077864
91Salivary secretion_Homo sapiens_hsa049700.29303112
92Glucagon signaling pathway_Homo sapiens_hsa049220.28078197
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27585322
94Galactose metabolism_Homo sapiens_hsa000520.27383522
95Dopaminergic synapse_Homo sapiens_hsa047280.27069102
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27061865
97One carbon pool by folate_Homo sapiens_hsa006700.25100195
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23636428
99Calcium signaling pathway_Homo sapiens_hsa040200.22817789
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.21215144
101Synaptic vesicle cycle_Homo sapiens_hsa047210.21024439
102Olfactory transduction_Homo sapiens_hsa047400.19800743
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15024764
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14967606
105Prion diseases_Homo sapiens_hsa050200.14720027
106Protein digestion and absorption_Homo sapiens_hsa049740.13172545
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11635626
108Linoleic acid metabolism_Homo sapiens_hsa005910.10503191
109Insulin signaling pathway_Homo sapiens_hsa049100.09967155
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06493496
111Renin-angiotensin system_Homo sapiens_hsa046140.00508691
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1624139
113Circadian rhythm_Homo sapiens_hsa04710-0.1445754
114Other glycan degradation_Homo sapiens_hsa00511-0.1221919
115Regulation of autophagy_Homo sapiens_hsa04140-0.1172579
116Oxidative phosphorylation_Homo sapiens_hsa00190-0.1147785
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0975183
118Lysosome_Homo sapiens_hsa04142-0.0876929
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0801348
120Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0760870
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0660168
122Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0631537
123Mineral absorption_Homo sapiens_hsa04978-0.0588916
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0525222
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0523436
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0362401
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0114151

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