ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of dendrite morphogenesis (GO:0050774)	7.61851812
2	response to pheromone (GO:0019236)	7.11476338
3	positive regulation of growth hormone secretion (GO:0060124)	7.04185653
4	sperm motility (GO:0030317)	6.82013522
5	acrosome reaction (GO:0007340)	6.76087964
6	growth hormone secretion (GO:0030252)	6.37061003
7	single strand break repair (GO:0000012)	6.00372067
8	fusion of sperm to egg plasma membrane (GO:0007342)	5.98049597
9	adult feeding behavior (GO:0008343)	5.83900735
10	regulation of growth hormone secretion (GO:0060123)	5.32785732
11	endocrine hormone secretion (GO:0060986)	5.27930307
12	positive regulation of steroid hormone secretion (GO:2000833)	5.25832103
13	positive regulation of protein autophosphorylation (GO:0031954)	5.17775047
14	regulation of glucocorticoid secretion (GO:2000849)	5.11580792
15	protein K11-linked deubiquitination (GO:0035871)	4.92990406
16	Rap protein signal transduction (GO:0032486)	4.89116590
17	negative regulation of interleukin-1 beta production (GO:0032691)	4.81860670
18	regulation of acrosome reaction (GO:0060046)	4.81317228
19	spermatid development (GO:0007286)	4.60605981
20	protein targeting to Golgi (GO:0000042)	4.57361329
21	establishment of protein localization to Golgi (GO:0072600)	4.56539615
22	multicellular organism reproduction (GO:0032504)	4.52884438
23	rRNA methylation (GO:0031167)	4.45041691
24	plasma membrane fusion (GO:0045026)	4.41149529
25	protein polyglutamylation (GO:0018095)	4.40951854
26	nephron tubule formation (GO:0072079)	4.35130483
27	DNA packaging (GO:0006323)	4.25412593
28	negative regulation of dendrite development (GO:2000171)	4.24889298
29	sperm capacitation (GO:0048240)	4.17366638
30	sperm-egg recognition (GO:0035036)	4.15422563
31	negative regulation of neurological system process (GO:0031645)	4.13825259
32	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.11633347
33	chromosome condensation (GO:0030261)	4.10022939
34	calcium ion-dependent exocytosis (GO:0017156)	4.06217795
35	regulation of cilium movement (GO:0003352)	4.04809295
36	regulation of corticosteroid hormone secretion (GO:2000846)	4.03296168
37	negative regulation of interleukin-1 production (GO:0032692)	3.98675190
38	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.95066773
39	cell wall macromolecule catabolic process (GO:0016998)	3.91025395
40	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.89153651
41	regulation of response to food (GO:0032095)	3.87438587
42	regulation of hexokinase activity (GO:1903299)	3.86454371
43	regulation of glucokinase activity (GO:0033131)	3.86454371
44	negative regulation of epithelial to mesenchymal transition (GO:0010719)	3.81419031
45	spermatid nucleus differentiation (GO:0007289)	3.81304281
46	lactate metabolic process (GO:0006089)	3.77579214
47	centriole replication (GO:0007099)	3.74621703
48	binding of sperm to zona pellucida (GO:0007339)	3.74549415
49	reproduction (GO:0000003)	3.71521096
50	cellular ketone body metabolic process (GO:0046950)	3.67044071
51	positive regulation of circadian rhythm (GO:0042753)	3.66067936
52	phosphatidylethanolamine metabolic process (GO:0046337)	3.66011400
53	rRNA modification (GO:0000154)	3.64440763
54	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.59956813
55	negative regulation of circadian rhythm (GO:0042754)	3.57474601
56	spermatogenesis (GO:0007283)	3.51665389
57	male gamete generation (GO:0048232)	3.50618721
58	negative regulation of hormone biosynthetic process (GO:0032353)	3.49033598
59	cell wall macromolecule metabolic process (GO:0044036)	3.47939415
60	regulation of centriole replication (GO:0046599)	3.47745198
61	positive regulation of response to extracellular stimulus (GO:0032106)	3.47020094
62	positive regulation of response to nutrient levels (GO:0032109)	3.47020094
63	coenzyme catabolic process (GO:0009109)	3.45912934
64	cell-cell recognition (GO:0009988)	3.35864853
65	protein localization to Golgi apparatus (GO:0034067)	3.35491086
66	polyamine biosynthetic process (GO:0006596)	3.26482800
67	regulation of appetite (GO:0032098)	3.25382295
68	negative regulation of stem cell differentiation (GO:2000737)	3.20871606
69	regulation of steroid hormone secretion (GO:2000831)	3.20447328
70	axonemal dynein complex assembly (GO:0070286)	3.19660839
71	ketone body metabolic process (GO:1902224)	3.19552706
72	gamete generation (GO:0007276)	3.17351757
73	genitalia morphogenesis (GO:0035112)	3.15592752
74	microtubule depolymerization (GO:0007019)	3.08867811
75	regulation of circadian sleep/wake cycle (GO:0042749)	3.08525714
76	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	3.08525714
77	regulation of centrosome duplication (GO:0010824)	3.08394200
78	otic vesicle formation (GO:0030916)	3.06635900
79	amine catabolic process (GO:0009310)	3.06563180
80	cellular biogenic amine catabolic process (GO:0042402)	3.06563180
81	cellular biogenic amine biosynthetic process (GO:0042401)	3.05715126
82	male sex determination (GO:0030238)	3.05031229
83	keratinocyte development (GO:0003334)	3.03909234
84	regulation of dendritic spine morphogenesis (GO:0061001)	3.02618301
85	microtubule severing (GO:0051013)	3.02308749
86	eye photoreceptor cell differentiation (GO:0001754)	3.02180011
87	photoreceptor cell differentiation (GO:0046530)	3.02180011
88	single fertilization (GO:0007338)	2.94066393
89	notochord development (GO:0030903)	2.89962998
90	negative regulation of hormone metabolic process (GO:0032351)	2.88926571
91	microtubule polymerization or depolymerization (GO:0031109)	2.87580827
92	amine biosynthetic process (GO:0009309)	2.82280518
93	epithelial cilium movement (GO:0003351)	2.82023438
94	centriole assembly (GO:0098534)	2.80375649
95	regulation of protein autophosphorylation (GO:0031952)	2.79652806
96	artery smooth muscle contraction (GO:0014824)	2.79145860
97	cAMP catabolic process (GO:0006198)	2.73376596
98	peptide secretion (GO:0002790)	2.73193539
99	regulation of cardioblast differentiation (GO:0051890)	2.73115430
100	protein K48-linked deubiquitination (GO:0071108)	2.73075504

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.83550711
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74456086
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62670686
4	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.60016001
5	FUS_26573619_Chip-Seq_HEK293_Human	2.58734930
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40084813
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30328890
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29107327
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.29107327
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.20043592
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.15737977
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.10690787
13	P300_19829295_ChIP-Seq_ESCs_Human	2.10208505
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03961013
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98546622
16	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.96995414
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.95017000
18	VDR_22108803_ChIP-Seq_LS180_Human	1.92010731
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90222596
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.89806311
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83418017
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.81977769
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.81977769
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.79642538
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.77198096
26	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.71679931
27	CJUN_26792858_Chip-Seq_BT549_Human	1.71265059
28	AR_25329375_ChIP-Seq_VCAP_Human	1.63708847
29	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.62655687
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62441678
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61043287
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.60505600
33	TP53_18474530_ChIP-ChIP_U2OS_Human	1.60416624
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55760243
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55731609
36	STAT3_23295773_ChIP-Seq_U87_Human	1.52345140
37	NFYB_21822215_ChIP-Seq_K562_Human	1.50987330
38	TBL1_22424771_ChIP-Seq_293T_Human	1.50498706
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.49130466
40	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.48602297
41	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.47757925
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.47457628
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.47279944
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.44691900
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.43888879
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43595785
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43595785
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42794725
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39916928
50	PHF8_20622853_ChIP-Seq_HELA_Human	1.37600746
51	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36832121
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35341794
53	ETV1_20927104_ChIP-Seq_GIST48_Human	1.32985879
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.32024018
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31928884
56	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.30394610
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.28689603
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.28689183
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27871097
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27445685
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26126668
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24805975
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.24281049
64	NFYA_21822215_ChIP-Seq_K562_Human	1.22438939
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21643298
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21604634
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21561327
68	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.20896986
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20677516
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.18354030
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18108738
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17810038
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16626906
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16008879
75	EWS_26573619_Chip-Seq_HEK293_Human	1.15486891
76	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.14453464
77	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.13832286
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13738790
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12706900
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12602480
81	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.12452352
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.12216820
83	TCF4_23295773_ChIP-Seq_U87_Human	1.11990486
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11753168
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10455434
86	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10036855
87	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.09506854
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08116453
89	BCAT_22108803_ChIP-Seq_LS180_Human	1.07605134
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06341688
91	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06263159
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06247541
93	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.05418566
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05346961
95	RXR_22108803_ChIP-Seq_LS180_Human	1.05016390
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04930148
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04560907
98	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04349245
99	ERA_21632823_ChIP-Seq_H3396_Human	1.04005386
100	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.02944350

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	6.90292887
2	MP0005410_abnormal_fertilization	6.86076618
3	MP0002138_abnormal_hepatobiliary_system	2.92242803
4	MP0008057_abnormal_DNA_replication	2.77301651
5	MP0003698_abnormal_male_reproductive	2.54876625
6	MP0003878_abnormal_ear_physiology	2.51953904
7	MP0005377_hearing/vestibular/ear_phenot	2.51953904
8	MP0002735_abnormal_chemical_nociception	2.46877418
9	MP0002282_abnormal_trachea_morphology	2.37815268
10	MP0003718_maternal_effect	2.33844278
11	MP0010352_gastrointestinal_tract_polyps	2.31883182
12	MP0001929_abnormal_gametogenesis	2.30360297
13	MP0003880_abnormal_central_pattern	2.17962445
14	MP0001984_abnormal_olfaction	2.17764661
15	MP0002102_abnormal_ear_morphology	2.11990606
16	MP0006276_abnormal_autonomic_nervous	2.09187127
17	MP0002234_abnormal_pharynx_morphology	2.00557642
18	MP0000537_abnormal_urethra_morphology	1.91206092
19	MP0001485_abnormal_pinna_reflex	1.82768549
20	MP0003787_abnormal_imprinting	1.82638502
21	MP0002693_abnormal_pancreas_physiology	1.80862154
22	MP0003122_maternal_imprinting	1.77559427
23	MP0010386_abnormal_urinary_bladder	1.75172740
24	MP0003123_paternal_imprinting	1.71573427
25	MP0005395_other_phenotype	1.59572611
26	MP0000538_abnormal_urinary_bladder	1.59013764
27	MP0008877_abnormal_DNA_methylation	1.57503081
28	MP0003011_delayed_dark_adaptation	1.52854269
29	MP0003121_genomic_imprinting	1.48282992
30	MP0000534_abnormal_ureter_morphology	1.47765361
31	MP0002249_abnormal_larynx_morphology	1.45630310
32	MP0005310_abnormal_salivary_gland	1.42497896
33	MP0000516_abnormal_urinary_system	1.42414468
34	MP0005367_renal/urinary_system_phenotyp	1.42414468
35	MP0002928_abnormal_bile_duct	1.40261062
36	MP0005266_abnormal_metabolism	1.37552999
37	MP0005645_abnormal_hypothalamus_physiol	1.36814625
38	MP0005551_abnormal_eye_electrophysiolog	1.36325586
39	MP0002161_abnormal_fertility/fecundity	1.36015407
40	MP0008058_abnormal_DNA_repair	1.32918620
41	MP0002132_abnormal_respiratory_system	1.26159225
42	MP0002168_other_aberrant_phenotype	1.22893541
43	MP0005220_abnormal_exocrine_pancreas	1.21298162
44	MP0005167_abnormal_blood-brain_barrier	1.20456642
45	MP0001765_abnormal_ion_homeostasis	1.19510802
46	MP0002909_abnormal_adrenal_gland	1.18655841
47	MP0001944_abnormal_pancreas_morphology	1.16622683
48	MP0001145_abnormal_male_reproductive	1.16618990
49	MP0010234_abnormal_vibrissa_follicle	1.14061392
50	MP0002210_abnormal_sex_determination	1.12421941
51	MP0003937_abnormal_limbs/digits/tail_de	1.09090826
52	MP0003045_fibrosis	1.08342567
53	MP0004742_abnormal_vestibular_system	1.07721063
54	MP0001501_abnormal_sleep_pattern	1.07470678
55	MP0002938_white_spotting	1.06788445
56	MP0001348_abnormal_lacrimal_gland	1.06621255
57	MP0000653_abnormal_sex_gland	1.06438592
58	MP0001879_abnormal_lymphatic_vessel	1.04173016
59	MP0004085_abnormal_heartbeat	1.03982203
60	MP0001486_abnormal_startle_reflex	1.03637391
61	MP0005379_endocrine/exocrine_gland_phen	1.02543233
62	MP0005636_abnormal_mineral_homeostasis	0.99942393
63	MP0003936_abnormal_reproductive_system	0.99135357
64	MP0008872_abnormal_physiological_respon	0.97217793
65	MP0002876_abnormal_thyroid_physiology	0.96899947
66	MP0000569_abnormal_digit_pigmentation	0.96819027
67	MP0009046_muscle_twitch	0.96437029
68	MP0002233_abnormal_nose_morphology	0.93438319
69	MP0000613_abnormal_salivary_gland	0.89900945
70	MP0005253_abnormal_eye_physiology	0.87237785
71	MP0002295_abnormal_pulmonary_circulatio	0.86031480
72	MP0001529_abnormal_vocalization	0.85214820
73	MP0009745_abnormal_behavioral_response	0.84978256
74	MP0003119_abnormal_digestive_system	0.82822225
75	MP0001963_abnormal_hearing_physiology	0.79136280
76	MP0004510_myositis	0.78450640
77	MP0010368_abnormal_lymphatic_system	0.78417644
78	MP0005248_abnormal_Harderian_gland	0.77363127
79	MP0003195_calcinosis	0.73849099
80	MP0002557_abnormal_social/conspecific_i	0.73451052
81	MP0002638_abnormal_pupillary_reflex	0.72224188
82	MP0000049_abnormal_middle_ear	0.72155647
83	MP0005332_abnormal_amino_acid	0.70367960
84	MP0000427_abnormal_hair_cycle	0.69300056
85	MP0003283_abnormal_digestive_organ	0.67567959
86	MP0000026_abnormal_inner_ear	0.66789899
87	MP0000678_abnormal_parathyroid_gland	0.66661131
88	MP0005376_homeostasis/metabolism_phenot	0.62470291
89	MP0003943_abnormal_hepatobiliary_system	0.62201345
90	MP0005647_abnormal_sex_gland	0.61712251
91	MP0001764_abnormal_homeostasis	0.59743159
92	MP0000631_abnormal_neuroendocrine_gland	0.57336493
93	MP0006036_abnormal_mitochondrial_physio	0.57332684
94	MP0003077_abnormal_cell_cycle	0.56621677
95	MP0001905_abnormal_dopamine_level	0.55065077
96	MP0001873_stomach_inflammation	0.54955194
97	MP0000230_abnormal_systemic_arterial	0.54609176
98	MP0005084_abnormal_gallbladder_morpholo	0.53730977
99	MP0004264_abnormal_extraembryonic_tissu	0.52625287
100	MP0003755_abnormal_palate_morphology	0.52209264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.56355213
2	Sensory axonal neuropathy (HP:0003390)	4.10640433
3	Abnormal sex determination (HP:0012244)	4.03019078
4	Sex reversal (HP:0012245)	4.03019078
5	Hypoglycemic seizures (HP:0002173)	4.01795441
6	Follicular hyperkeratosis (HP:0007502)	3.89582961
7	Atonic seizures (HP:0010819)	3.88974892
8	Tubulointerstitial nephritis (HP:0001970)	3.82018555
9	11 pairs of ribs (HP:0000878)	3.80581212
10	True hermaphroditism (HP:0010459)	3.67049757
11	Attenuation of retinal blood vessels (HP:0007843)	3.49525095
12	Chronic hepatic failure (HP:0100626)	3.42478385
13	Abnormality of dental color (HP:0011073)	3.35126769
14	Hyperinsulinemic hypoglycemia (HP:0000825)	3.27515146
15	Alopecia of scalp (HP:0002293)	3.25206234
16	Pancreatic islet-cell hyperplasia (HP:0004510)	3.21496151
17	Large for gestational age (HP:0001520)	3.21286752
18	Insulin-resistant diabetes mellitus (HP:0000831)	3.10681084
19	Hypoglycemic coma (HP:0001325)	2.97230543
20	Medial flaring of the eyebrow (HP:0010747)	2.82532136
21	Facial shape deformation (HP:0011334)	2.78809126
22	Potter facies (HP:0002009)	2.78809126
23	Abnormality of the renal medulla (HP:0100957)	2.78410523
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.75874546
25	Absent/shortened dynein arms (HP:0200106)	2.72876205
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72876205
27	Nephronophthisis (HP:0000090)	2.72709069
28	Hypoalphalipoproteinemia (HP:0003233)	2.71298197
29	Steatorrhea (HP:0002570)	2.69956227
30	Abnormality of the pancreatic islet cells (HP:0006476)	2.69836061
31	Abnormality of endocrine pancreas physiology (HP:0012093)	2.69836061
32	Vascular calcification (HP:0004934)	2.68449363
33	Abnormality of macular pigmentation (HP:0008002)	2.67637374
34	Bony spicule pigmentary retinopathy (HP:0007737)	2.59385839
35	Prominent metopic ridge (HP:0005487)	2.50763813
36	Progressive cerebellar ataxia (HP:0002073)	2.44563286
37	Pancreatic cysts (HP:0001737)	2.42883617
38	Febrile seizures (HP:0002373)	2.39054908
39	Congenital primary aphakia (HP:0007707)	2.37318278
40	Pancreatic fibrosis (HP:0100732)	2.36374052
41	Hypokinesia (HP:0002375)	2.35819145
42	Tubulointerstitial abnormality (HP:0001969)	2.34258320
43	Gait imbalance (HP:0002141)	2.31937373
44	Abnormality of the metopic suture (HP:0005556)	2.31715679
45	Cardiovascular calcification (HP:0011915)	2.27585788
46	Breast carcinoma (HP:0003002)	2.25045439
47	Congenital, generalized hypertrichosis (HP:0004540)	2.23899069
48	Hemiparesis (HP:0001269)	2.22915133
49	Abnormal ciliary motility (HP:0012262)	2.12120344
50	Exocrine pancreatic insufficiency (HP:0001738)	2.11041012
51	Hyperglycemia (HP:0003074)	2.10374832
52	Asymmetric septal hypertrophy (HP:0001670)	2.09336275
53	Missing ribs (HP:0000921)	2.08542374
54	Glioma (HP:0009733)	2.08421422
55	Colon cancer (HP:0003003)	2.07186581
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07114767
57	Abnormality of renal excretion (HP:0011036)	2.06402485
58	Poor speech (HP:0002465)	2.05477243
59	Fibular hypoplasia (HP:0003038)	2.04209420
60	Genetic anticipation (HP:0003743)	2.03222414
61	Neonatal short-limb short stature (HP:0008921)	2.02331159
62	Bradycardia (HP:0001662)	2.01938429
63	Abnormality of midbrain morphology (HP:0002418)	2.01826914
64	Molar tooth sign on MRI (HP:0002419)	2.01826914
65	Intrahepatic cholestasis (HP:0001406)	2.00311240
66	Tubular atrophy (HP:0000092)	1.98067616
67	Optic nerve hypoplasia (HP:0000609)	1.97705872
68	Ketoacidosis (HP:0001993)	1.97286485
69	Abnormality of the renal cortex (HP:0011035)	1.96138116
70	Genital tract atresia (HP:0001827)	1.94650157
71	Hypoplastic iliac wings (HP:0002866)	1.94151119
72	Astrocytoma (HP:0009592)	1.93300546
73	Abnormality of the astrocytes (HP:0100707)	1.93300546
74	Nephrogenic diabetes insipidus (HP:0009806)	1.93016526
75	Respiratory distress (HP:0002098)	1.92864228
76	Fat malabsorption (HP:0002630)	1.92582443
77	Menstrual irregularities (HP:0000858)	1.92433873
78	Hypophosphatemic rickets (HP:0004912)	1.92244681
79	Stage 5 chronic kidney disease (HP:0003774)	1.90331722
80	Sparse eyelashes (HP:0000653)	1.90213413
81	Patent foramen ovale (HP:0001655)	1.90159687
82	Generalized myoclonic seizures (HP:0002123)	1.88915981
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88605035
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.88605035
85	Symptomatic seizures (HP:0011145)	1.88056077
86	Increased corneal curvature (HP:0100692)	1.87536791
87	Keratoconus (HP:0000563)	1.87536791
88	Vaginal atresia (HP:0000148)	1.86419550
89	Late onset (HP:0003584)	1.85516947
90	Male pseudohermaphroditism (HP:0000037)	1.85191718
91	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.84697891
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.84118113
93	Hypochromic microcytic anemia (HP:0004840)	1.84080746
94	Stomatitis (HP:0010280)	1.83328742
95	Bronchomalacia (HP:0002780)	1.83283477
96	Pigmentary retinal degeneration (HP:0001146)	1.79553902
97	Abnormal urine output (HP:0012590)	1.79370218
98	Cerebellar dysplasia (HP:0007033)	1.76999981
99	Stomach cancer (HP:0012126)	1.75985855
100	Rhabdomyosarcoma (HP:0002859)	1.75778920

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.97504485
2	FRK	4.84354127
3	TNIK	3.64540724
4	PLK4	3.54671547
5	TRIM28	3.05732017
6	BMPR1B	2.99531714
7	GRK1	2.29374090
8	STK38L	2.18224826
9	INSRR	2.11683164
10	EPHA2	2.10237039
11	MAP3K4	2.08273222
12	BRD4	2.02252136
13	PLK2	1.84327671
14	CASK	1.82642456
15	MAP4K2	1.79830503
16	STK24	1.78413654
17	NLK	1.78103402
18	MAP2K7	1.71346269
19	STK38	1.69191204
20	BRSK2	1.64124683
21	MKNK2	1.57406076
22	FGFR2	1.44120345
23	DDR2	1.41500433
24	NTRK3	1.39100465
25	BMPR2	1.37366002
26	PNCK	1.35171236
27	PASK	1.34766268
28	DYRK3	1.23073334
29	AKT3	1.21955786
30	STK3	1.21086413
31	TESK1	1.17068734
32	PTK2B	1.12830117
33	OXSR1	1.12798841
34	CSNK1G1	1.02273835
35	ZAK	1.01390957
36	STK39	0.99355145
37	PIK3CG	0.97172523
38	MST1R	0.95587413
39	ADRBK2	0.94777373
40	PRKAA2	0.92547231
41	WEE1	0.91265703
42	FER	0.88002619
43	ROCK1	0.87684290
44	CSNK1A1L	0.86915939
45	STK10	0.83441512
46	PAK3	0.80614105
47	CSNK1G3	0.80504456
48	MAP3K9	0.79479737
49	CAMK1G	0.79443153
50	WNK4	0.76869254
51	EIF2AK3	0.74750368
52	NUAK1	0.73690755
53	DYRK1A	0.73022996
54	BCR	0.71738128
55	TEC	0.71475435
56	PRKCG	0.71376665
57	IKBKB	0.68979283
58	WNK3	0.67768765
59	CSNK1G2	0.67143919
60	CDK3	0.66475381
61	PRKCI	0.65203777
62	EIF2AK1	0.64504862
63	TLK1	0.61409550
64	PRKAA1	0.57876539
65	MAPK15	0.57684853
66	SIK3	0.56140354
67	MINK1	0.55933535
68	NEK6	0.53273046
69	MKNK1	0.52960025
70	VRK1	0.50631597
71	WNK1	0.50066491
72	PRKCE	0.49939481
73	ACVR1B	0.46808656
74	ERBB3	0.46763177
75	YES1	0.42697856
76	DYRK1B	0.40253124
77	BRSK1	0.40108688
78	MAP2K1	0.39975090
79	CSNK1A1	0.38846879
80	TIE1	0.37814538
81	IRAK1	0.37643553
82	ADRBK1	0.36140598
83	MAP2K2	0.36119852
84	DYRK2	0.34703866
85	PLK3	0.34476291
86	PLK1	0.33371626
87	DAPK2	0.33301537
88	FGFR1	0.31760840
89	PRKCB	0.30609307
90	PIK3CA	0.29554667
91	CDC7	0.29111714
92	PRKACA	0.25690426
93	MAP3K2	0.25482893
94	MAPK1	0.24628010
95	AKT1	0.23419103
96	PRKCQ	0.23314765
97	CAMK2A	0.22572023
98	EPHB2	0.21644807
99	MAPK13	0.20820377
100	GSK3B	0.20626636

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.35936531
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.16179128
3	Butanoate metabolism_Homo sapiens_hsa00650	3.63165479
4	Olfactory transduction_Homo sapiens_hsa04740	2.72934912
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38461222
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.28248284
7	Type II diabetes mellitus_Homo sapiens_hsa04930	2.25968216
8	Phototransduction_Homo sapiens_hsa04744	2.18389664
9	Arginine and proline metabolism_Homo sapiens_hsa00330	2.07540982
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.01980480
11	Taste transduction_Homo sapiens_hsa04742	1.98186968
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.83829677
13	Circadian rhythm_Homo sapiens_hsa04710	1.73190262
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72405512
15	Homologous recombination_Homo sapiens_hsa03440	1.70155359
16	Protein export_Homo sapiens_hsa03060	1.70063607
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.66447849
18	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.63874219
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.59420703
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57348736
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51687777
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.47527714
23	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.47209128
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40433751
25	Mismatch repair_Homo sapiens_hsa03430	1.38285808
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32131685
27	Basal transcription factors_Homo sapiens_hsa03022	1.29718925
28	Propanoate metabolism_Homo sapiens_hsa00640	1.29427049
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.26587022
30	Regulation of autophagy_Homo sapiens_hsa04140	1.23693674
31	Fatty acid degradation_Homo sapiens_hsa00071	1.22647029
32	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.16506052
33	ABC transporters_Homo sapiens_hsa02010	1.15958504
34	Purine metabolism_Homo sapiens_hsa00230	1.15011634
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13392255
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11002370
37	Insulin secretion_Homo sapiens_hsa04911	1.10250453
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.08255110
39	Tight junction_Homo sapiens_hsa04530	0.98009578
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97721271
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95104474
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.93733846
43	One carbon pool by folate_Homo sapiens_hsa00670	0.90360934
44	Basal cell carcinoma_Homo sapiens_hsa05217	0.90220842
45	RNA transport_Homo sapiens_hsa03013	0.89207047
46	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.88324797
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.85578938
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85063693
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84990952
50	Retinol metabolism_Homo sapiens_hsa00830	0.84969679
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.82769501
52	Serotonergic synapse_Homo sapiens_hsa04726	0.79773132
53	Morphine addiction_Homo sapiens_hsa05032	0.79336330
54	Fatty acid elongation_Homo sapiens_hsa00062	0.77820581
55	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74895634
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.73995178
57	Phenylalanine metabolism_Homo sapiens_hsa00360	0.71943813
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.71121896
59	Histidine metabolism_Homo sapiens_hsa00340	0.70325513
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65739240
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60209248
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.59319162
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.58977133
64	RNA polymerase_Homo sapiens_hsa03020	0.58484934
65	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58155090
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.56535769
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55145436
68	Metabolic pathways_Homo sapiens_hsa01100	0.54951642
69	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.54895995
70	Circadian entrainment_Homo sapiens_hsa04713	0.54525992
71	Salivary secretion_Homo sapiens_hsa04970	0.54031533
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.53664016
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.53149961
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52218084
75	Oocyte meiosis_Homo sapiens_hsa04114	0.49607978
76	Complement and coagulation cascades_Homo sapiens_hsa04610	0.49324394
77	Alcoholism_Homo sapiens_hsa05034	0.46440067
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45433849
79	Lysine degradation_Homo sapiens_hsa00310	0.44691420
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43846230
81	Peroxisome_Homo sapiens_hsa04146	0.42133372
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.41961492
83	Insulin resistance_Homo sapiens_hsa04931	0.40704021
84	Amphetamine addiction_Homo sapiens_hsa05031	0.38759798
85	Renin secretion_Homo sapiens_hsa04924	0.37882015
86	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36595244
87	Folate biosynthesis_Homo sapiens_hsa00790	0.34648552
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34269095
89	Caffeine metabolism_Homo sapiens_hsa00232	0.32672365
90	DNA replication_Homo sapiens_hsa03030	0.32023080
91	Axon guidance_Homo sapiens_hsa04360	0.31847087
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31209824
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.30947409
94	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.30334374
95	Proteasome_Homo sapiens_hsa03050	0.29221568
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.28836981
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.27113214
98	Adherens junction_Homo sapiens_hsa04520	0.25870385
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25460095
100	Thyroid cancer_Homo sapiens_hsa05216	0.25000036

ALDH7A1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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