ALDH9A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.92152182
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.92152182
3L-phenylalanine metabolic process (GO:0006558)6.74056699
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74056699
5aromatic amino acid family catabolic process (GO:0009074)6.26665166
6tryptophan catabolic process (GO:0006569)5.64310015
7indole-containing compound catabolic process (GO:0042436)5.64310015
8indolalkylamine catabolic process (GO:0046218)5.64310015
9cysteine metabolic process (GO:0006534)5.63093499
10glyoxylate metabolic process (GO:0046487)5.61637486
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.47213084
12kynurenine metabolic process (GO:0070189)5.40181242
13tryptophan metabolic process (GO:0006568)5.33198969
14sulfur amino acid catabolic process (GO:0000098)5.14893706
15bile acid biosynthetic process (GO:0006699)5.12612663
16alpha-linolenic acid metabolic process (GO:0036109)5.11983435
17lysine metabolic process (GO:0006553)5.06329484
18lysine catabolic process (GO:0006554)5.06329484
19urea cycle (GO:0000050)5.02831450
20urea metabolic process (GO:0019627)5.02831450
21serine family amino acid catabolic process (GO:0009071)4.96796857
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90775571
23homocysteine metabolic process (GO:0050667)4.73572071
24high-density lipoprotein particle remodeling (GO:0034375)4.68836278
25nitrogen cycle metabolic process (GO:0071941)4.64952308
26NADH metabolic process (GO:0006734)4.62340492
27aromatic amino acid family metabolic process (GO:0009072)4.58966484
28* amino-acid betaine metabolic process (GO:0006577)4.58689810
29serine family amino acid biosynthetic process (GO:0009070)4.57088532
30glycine metabolic process (GO:0006544)4.57081883
31serine family amino acid metabolic process (GO:0009069)4.53464711
32bile acid metabolic process (GO:0008206)4.44161568
33protein carboxylation (GO:0018214)4.43596232
34peptidyl-glutamic acid carboxylation (GO:0017187)4.43596232
35tricarboxylic acid cycle (GO:0006099)4.40455110
36drug catabolic process (GO:0042737)4.39416017
37biotin metabolic process (GO:0006768)4.38964175
38urate metabolic process (GO:0046415)4.38428107
39alpha-amino acid catabolic process (GO:1901606)4.36610662
40negative regulation of fibrinolysis (GO:0051918)4.33156922
41regulation of triglyceride catabolic process (GO:0010896)4.30847466
42regulation of cholesterol esterification (GO:0010872)4.29067615
43complement activation, alternative pathway (GO:0006957)4.25614574
44drug transmembrane transport (GO:0006855)4.24179162
45regulation of protein activation cascade (GO:2000257)4.19533852
46tyrosine metabolic process (GO:0006570)4.17022268
47plasma lipoprotein particle remodeling (GO:0034369)4.15732396
48protein-lipid complex remodeling (GO:0034368)4.15732396
49macromolecular complex remodeling (GO:0034367)4.15732396
50reverse cholesterol transport (GO:0043691)4.10244886
51cellular amino acid catabolic process (GO:0009063)4.08495562
52branched-chain amino acid catabolic process (GO:0009083)4.08296838
53negative regulation of cholesterol transport (GO:0032375)4.06105116
54negative regulation of sterol transport (GO:0032372)4.06105116
55regulation of fibrinolysis (GO:0051917)4.06007169
56cellular ketone body metabolic process (GO:0046950)4.02575068
57acylglycerol homeostasis (GO:0055090)3.98837404
58triglyceride homeostasis (GO:0070328)3.98837404
59cellular modified amino acid catabolic process (GO:0042219)3.98578317
60indolalkylamine metabolic process (GO:0006586)3.97277614
61L-serine metabolic process (GO:0006563)3.96277007
62phospholipid efflux (GO:0033700)3.93736288
63aldehyde catabolic process (GO:0046185)3.93546985
64bile acid and bile salt transport (GO:0015721)3.92431421
65regulation of complement activation (GO:0030449)3.92338722
66cellular biogenic amine catabolic process (GO:0042402)3.92176140
67amine catabolic process (GO:0009310)3.92176140
68ethanol oxidation (GO:0006069)3.91235618
69glutamate metabolic process (GO:0006536)3.90341099
70coenzyme catabolic process (GO:0009109)3.84837330
71benzene-containing compound metabolic process (GO:0042537)3.80494888
72epoxygenase P450 pathway (GO:0019373)3.77969459
73imidazole-containing compound metabolic process (GO:0052803)3.77709740
74short-chain fatty acid metabolic process (GO:0046459)3.77066553
75plasma lipoprotein particle clearance (GO:0034381)3.75871214
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.70977885
77exogenous drug catabolic process (GO:0042738)3.70698261
78drug transport (GO:0015893)3.70230107
79response to nitrosative stress (GO:0051409)3.69644777
80carboxylic acid catabolic process (GO:0046395)3.66101499
81organic acid catabolic process (GO:0016054)3.66101499
82acetyl-CoA metabolic process (GO:0006084)3.64440499
83aspartate family amino acid catabolic process (GO:0009068)3.64254274
84glucuronate metabolic process (GO:0019585)3.62982128
85uronic acid metabolic process (GO:0006063)3.62982128
86plasma lipoprotein particle assembly (GO:0034377)3.62981433
87xenobiotic catabolic process (GO:0042178)3.62692795
88cholesterol efflux (GO:0033344)3.60208276
89cellular glucuronidation (GO:0052695)3.59790780
90valine metabolic process (GO:0006573)3.59537102
91fatty acid beta-oxidation (GO:0006635)3.59370947
92primary alcohol catabolic process (GO:0034310)3.58544826
93low-density lipoprotein particle remodeling (GO:0034374)3.55915498
94COPI coating of Golgi vesicle (GO:0048205)3.55287979
95Golgi transport vesicle coating (GO:0048200)3.55287979
96phenylpropanoid metabolic process (GO:0009698)3.55250680
97fatty acid oxidation (GO:0019395)3.53658638
98branched-chain amino acid metabolic process (GO:0009081)3.53452053
99cholesterol homeostasis (GO:0042632)3.49946133
100dicarboxylic acid biosynthetic process (GO:0043650)3.49727860
101intestinal cholesterol absorption (GO:0030299)3.49254673
102drug metabolic process (GO:0017144)3.48192879
103regulation of cholesterol homeostasis (GO:2000188)3.47246384
104ketone body metabolic process (GO:1902224)3.47195554
105lipid oxidation (GO:0034440)3.46889464
106sterol homeostasis (GO:0055092)3.46656292
107positive regulation of triglyceride lipase activity (GO:0061365)3.46642745
108positive regulation of lipoprotein lipase activity (GO:0051006)3.46642745
109arginine metabolic process (GO:0006525)3.46617858
110ethanol metabolic process (GO:0006067)3.45959252
111polyketide metabolic process (GO:0030638)3.45830566
112doxorubicin metabolic process (GO:0044598)3.45830566
113daunorubicin metabolic process (GO:0044597)3.45830566
1142-oxoglutarate metabolic process (GO:0006103)3.42738466
115monocarboxylic acid catabolic process (GO:0072329)3.42521477
116very-low-density lipoprotein particle assembly (GO:0034379)3.41641881
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.41625771
118cofactor catabolic process (GO:0051187)3.41505748
119omega-hydroxylase P450 pathway (GO:0097267)3.41461873
120fatty acid catabolic process (GO:0009062)3.40036632
121* carnitine metabolic process (GO:0009437)3.39278577
122heme transport (GO:0015886)3.39043624
123fat-soluble vitamin biosynthetic process (GO:0042362)3.35799849
124oxaloacetate metabolic process (GO:0006107)3.26905223
125primary alcohol metabolic process (GO:0034308)3.23121355
126triglyceride catabolic process (GO:0019433)3.20310835
127very long-chain fatty acid metabolic process (GO:0000038)3.18258117
128fatty acid elongation (GO:0030497)3.12486168
129aminoglycoside antibiotic metabolic process (GO:0030647)3.07718121
130acyl-CoA metabolic process (GO:0006637)3.01742983
131thioester metabolic process (GO:0035383)3.01742983
132vitamin biosynthetic process (GO:0009110)2.99299253
133peroxisome fission (GO:0016559)2.98687228
134lipid particle organization (GO:0034389)2.97033392
135COPII vesicle coating (GO:0048208)2.96704224
136* cellular aldehyde metabolic process (GO:0006081)2.90730503
137blood coagulation, intrinsic pathway (GO:0007597)2.89185423
138neutral lipid catabolic process (GO:0046461)2.86933987
139acylglycerol catabolic process (GO:0046464)2.86933987
140gluconeogenesis (GO:0006094)2.85653581
141regulation of sequestering of triglyceride (GO:0010889)2.78219319
142fatty acid homeostasis (GO:0055089)2.75969719
143response to phenylpropanoid (GO:0080184)2.74230656
144fibrinolysis (GO:0042730)2.72618153
145tricarboxylic acid metabolic process (GO:0072350)2.72497622
146quinone metabolic process (GO:1901661)2.70327086
147hexose biosynthetic process (GO:0019319)2.70223755
148glutamine family amino acid biosynthetic process (GO:0009084)2.67265066
149cullin deneddylation (GO:0010388)2.67241289
150succinate metabolic process (GO:0006105)2.65517294
151water-soluble vitamin biosynthetic process (GO:0042364)2.62798657
152fatty-acyl-CoA metabolic process (GO:0035337)2.58003434
153retinol metabolic process (GO:0042572)2.57784924
154monosaccharide biosynthetic process (GO:0046364)2.57265069
155ribosome assembly (GO:0042255)2.54919322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.81237448
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.94370949
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.14837134
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.69776683
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.23597935
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.55194071
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45885254
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.99004362
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80463239
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85474392
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.49158459
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25698746
13ELK1_19687146_ChIP-ChIP_HELA_Human2.09164849
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08937220
15* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07440507
16E2F7_22180533_ChIP-Seq_HELA_Human1.97625677
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92739843
18* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92324364
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83536214
20GATA1_22025678_ChIP-Seq_K562_Human1.80373938
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77104690
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.69109410
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67987939
24* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57724142
25* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52914212
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50735591
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46567953
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45003907
29TFEB_21752829_ChIP-Seq_HELA_Human1.44533241
30AR_21909140_ChIP-Seq_LNCAP_Human1.43937370
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43832244
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41140819
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39807216
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36257572
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32920515
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31583647
37CLOCK_20551151_ChIP-Seq_293T_Human1.29867947
38EOMES_21245162_ChIP-Seq_HESCs_Human1.29390225
39FUS_26573619_Chip-Seq_HEK293_Human1.27643697
40SOX17_20123909_ChIP-Seq_XEN_Mouse1.25752777
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.25568327
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.25561014
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25398084
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.23543812
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.23421109
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.23414364
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22815414
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21883508
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21862007
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21011100
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20155020
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.19016934
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16457028
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15020567
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13080468
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12082891
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.09723832
58RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08765501
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08392347
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.08139325
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07925975
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06953330
63CBP_21632823_ChIP-Seq_H3396_Human1.06940719
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05841821
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03662977
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01386404
67GATA4_25053715_ChIP-Seq_YYC3_Human1.00694839
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00296296
69* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99668159
70* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98901037
71HTT_18923047_ChIP-ChIP_STHdh_Human0.98831981
72* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98445734
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98430689
74GABP_19822575_ChIP-Seq_HepG2_Human0.97978909
75CDX2_22108803_ChIP-Seq_LS180_Human0.96912801
76SOX2_20726797_ChIP-Seq_SW620_Human0.96683613
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96489650
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95579765
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95579765
80* PHF8_20622853_ChIP-Seq_HELA_Human0.94081114
81MYC_18555785_ChIP-Seq_MESCs_Mouse0.92705709
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92502125
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92098313
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92044569
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.91804513
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90843986
87* HNFA_21074721_ChIP-Seq_CACO-2_Human0.90751960
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90293206
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90123686
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89677752
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.89663717
92VDR_23849224_ChIP-Seq_CD4+_Human0.89500457
93* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89039024
94* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88879523
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88576055
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88094847
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87515305
98* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87412270
99* SRF_21415370_ChIP-Seq_HL-1_Mouse0.87370281
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87323970
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87137390
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.87075808
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85417010
104GATA6_25053715_ChIP-Seq_YYC3_Human0.82566644
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82084590
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81909443
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81196467
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80113960
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80082576
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.79755026
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79068604
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.78619792
113IRF8_21731497_ChIP-ChIP_J774_Mouse0.77204663
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76825181
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76720433
116* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76519750
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75029188
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74773097
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.74276112
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74105897
121SCL_19346495_ChIP-Seq_HPC-7_Human0.72908507
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71627498
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.68551221
124* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67178566
125* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66994110
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66221411
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64970070
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64967625
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63801471
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.63163497
131IRF1_19129219_ChIP-ChIP_H3396_Human0.62568689
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62494286
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.62209199
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62053595
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62006824
136* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61911201
137* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60633513
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.60492896
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59149388
140CEBPB_22108803_ChIP-Seq_LS180_Human0.58570944
141AR_20517297_ChIP-Seq_VCAP_Human0.58515856
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58323328
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57505236
144* IRF8_27001747_Chip-Seq_BMDM_Mouse0.57443177
145* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57231089
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57132720
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56607299
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56413099
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.56093128
150MYC_19030024_ChIP-ChIP_MESCs_Mouse0.55731475
151DCP1A_22483619_ChIP-Seq_HELA_Human0.55728314
152FOXP3_21729870_ChIP-Seq_TREG_Human0.55596675
153NELFA_20434984_ChIP-Seq_ESCs_Mouse0.55221857
154* BCOR_27268052_Chip-Seq_Bcells_Human0.54880185
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54662637
156EST1_17652178_ChIP-ChIP_JURKAT_Human0.54618222
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.54521513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.54555701
2MP0002139_abnormal_hepatobiliary_system7.48694233
3MP0005085_abnormal_gallbladder_physiolo5.49939364
4MP0005365_abnormal_bile_salt5.42672294
5MP0008875_abnormal_xenobiotic_pharmacok4.53279545
6MP0003806_abnormal_nucleotide_metabolis4.34754267
7MP0010234_abnormal_vibrissa_follicle3.65397292
8MP0009840_abnormal_foam_cell3.54680721
9MP0003252_abnormal_bile_duct3.49157421
10MP0010329_abnormal_lipoprotein_level3.09733831
11MP0005332_abnormal_amino_acid2.96069233
12MP0003195_calcinosis2.69686242
13MP0001666_abnormal_nutrient_absorption2.61295591
14MP0005083_abnormal_biliary_tract2.52237541
15MP0004019_abnormal_vitamin_homeostasis2.40242025
16MP0002138_abnormal_hepatobiliary_system2.36098360
17MP0003941_abnormal_skin_development2.29215614
18MP0003191_abnormal_cellular_cholesterol2.21115921
19MP0000609_abnormal_liver_physiology2.05365682
20MP0004272_abnormal_basement_membrane1.98206365
21MP0003136_yellow_coat_color1.92613414
22MP0002118_abnormal_lipid_homeostasis1.92221370
23MP0002090_abnormal_vision1.87195585
24MP0003186_abnormal_redox_activity1.85192244
25MP0005319_abnormal_enzyme/_coenzyme1.84318060
26MP0009643_abnormal_urine_homeostasis1.77532586
27MP0000372_irregular_coat_pigmentation1.77437864
28MP0001764_abnormal_homeostasis1.73380426
29MP0005171_absent_coat_pigmentation1.65693421
30MP0005451_abnormal_body_composition1.63085784
31MP0005584_abnormal_enzyme/coenzyme_acti1.58307481
32MP0003868_abnormal_feces_composition1.54971984
33MP0006054_spinal_hemorrhage1.54301925
34MP0003656_abnormal_erythrocyte_physiolo1.52783929
35MP0010352_gastrointestinal_tract_polyps1.52067565
36MP0001881_abnormal_mammary_gland1.43952696
37MP0005636_abnormal_mineral_homeostasis1.27188431
38MP0000598_abnormal_liver_morphology1.26313768
39MP0009697_abnormal_copulation1.25180703
40MP0000749_muscle_degeneration1.25089625
41MP0008438_abnormal_cutaneous_collagen1.21842387
42MP0004215_abnormal_myocardial_fiber1.21405155
43MP0000751_myopathy1.20969578
44MP0006036_abnormal_mitochondrial_physio1.20943202
45MP0002909_abnormal_adrenal_gland1.17878942
46MP0002796_impaired_skin_barrier1.16461934
47MP0005670_abnormal_white_adipose1.15778562
48MP0003011_delayed_dark_adaptation1.14468190
49MP0005275_abnormal_skin_tensile1.12657031
50MP0009780_abnormal_chondrocyte_physiolo1.12171007
51MP0003566_abnormal_cell_adhesion1.11206446
52MP0002638_abnormal_pupillary_reflex1.07789686
53MP0004043_abnormal_pH_regulation1.07617912
54MP0002295_abnormal_pulmonary_circulatio1.05876814
55MP0002938_white_spotting1.05607673
56MP0005248_abnormal_Harderian_gland1.05275378
57MP0008469_abnormal_protein_level1.04835146
58MP0003718_maternal_effect1.03844923
59MP0009763_increased_sensitivity_to1.02179078
60MP0005058_abnormal_lysosome_morphology1.00068091
61MP0002877_abnormal_melanocyte_morpholog1.00006227
62MP0005408_hypopigmentation0.97349780
63MP0009764_decreased_sensitivity_to0.95874474
64MP0005375_adipose_tissue_phenotype0.95828758
65MP0001756_abnormal_urination0.93988795
66MP0000371_diluted_coat_color0.93918405
67MP0000013_abnormal_adipose_tissue0.91922133
68MP0005220_abnormal_exocrine_pancreas0.91472546
69MP0001324_abnormal_eye_pigmentation0.90767462
70MP0002060_abnormal_skin_morphology0.90178121
71MP0005187_abnormal_penis_morphology0.90088751
72MP0009642_abnormal_blood_homeostasis0.89571402
73MP0004233_abnormal_muscle_weight0.88984853
74MP0006138_congestive_heart_failure0.88577562
75MP0003959_abnormal_lean_body0.87483288
76MP0005330_cardiomyopathy0.87217149
77MP0005647_abnormal_sex_gland0.87011008
78MP0002136_abnormal_kidney_physiology0.87006948
79MP0008058_abnormal_DNA_repair0.86411004
80MP0000604_amyloidosis0.86224993
81MP0005084_abnormal_gallbladder_morpholo0.85791910
82MP0004957_abnormal_blastocyst_morpholog0.84761119
83MP0005174_abnormal_tail_pigmentation0.83854518
84MP0009703_decreased_birth_body0.83380040
85MP0009765_abnormal_xenobiotic_induced0.82530017
86MP0000015_abnormal_ear_pigmentation0.82213772
87MP0000003_abnormal_adipose_tissue0.81163943
88MP0003567_abnormal_fetal_cardiomyocyte0.80958831
89MP0004264_abnormal_extraembryonic_tissu0.80779405
90MP0005464_abnormal_platelet_physiology0.79449473
91MP0000647_abnormal_sebaceous_gland0.78341715
92MP0005376_homeostasis/metabolism_phenot0.77387726
93MP0002078_abnormal_glucose_homeostasis0.76897432
94MP0008007_abnormal_cellular_replicative0.76600223
95MP0002269_muscular_atrophy0.76162962
96MP0005253_abnormal_eye_physiology0.75707212
97MP0001984_abnormal_olfaction0.74646787
98MP0005367_renal/urinary_system_phenotyp0.74590221
99MP0000516_abnormal_urinary_system0.74590221
100MP0009384_cardiac_valve_regurgitation0.74292076
101MP0003436_decreased_susceptibility_to0.73995167
102MP0003705_abnormal_hypodermis_morpholog0.73932579
103MP0001186_pigmentation_phenotype0.72678234
104MP0008260_abnormal_autophagy0.72081174
105MP0000569_abnormal_digit_pigmentation0.70824439
106MP0003724_increased_susceptibility_to0.70123988
107MP0005266_abnormal_metabolism0.69233526
108MP0001661_extended_life_span0.69060456
109MP0005385_cardiovascular_system_phenoty0.68044620
110MP0001544_abnormal_cardiovascular_syste0.68044620
111MP0000747_muscle_weakness0.67474404
112MP0002971_abnormal_brown_adipose0.65340034
113MP0005395_other_phenotype0.63798394
114MP0006035_abnormal_mitochondrial_morpho0.62286913
115MP0002254_reproductive_system_inflammat0.61962676
116MP0004147_increased_porphyrin_level0.61802411
117MP0005334_abnormal_fat_pad0.61198706
118MP0002876_abnormal_thyroid_physiology0.61039856
119MP0001765_abnormal_ion_homeostasis0.59775860
120MP0005666_abnormal_adipose_tissue0.58776841
121MP0003300_gastrointestinal_ulcer0.58626993
122MP0001853_heart_inflammation0.58254431
123MP0008873_increased_physiological_sensi0.58116010
124MP0001845_abnormal_inflammatory_respons0.57458816
125MP0005535_abnormal_body_temperature0.52230770
126MP0003638_abnormal_response/metabolism_0.49823234
127MP0000639_abnormal_adrenal_gland0.48364567
128MP0004782_abnormal_surfactant_physiolog0.47953757
129MP0006082_CNS_inflammation0.47158997
130MP0010368_abnormal_lymphatic_system0.47008977
131MP0002970_abnormal_white_adipose0.46117749
132MP0009672_abnormal_birth_weight0.45654723
133MP0003690_abnormal_glial_cell0.43050909
134MP0005025_abnormal_response_to0.41995145
135MP0002928_abnormal_bile_duct0.41783723
136MP0002419_abnormal_innate_immunity0.41732876
137MP0005448_abnormal_energy_balance0.41000045
138MP0002135_abnormal_kidney_morphology0.40945616
139MP0001835_abnormal_antigen_presentation0.40269663
140MP0003953_abnormal_hormone_level0.39836052
141MP0004130_abnormal_muscle_cell0.38224849
142MP0009115_abnormal_fat_cell0.37389311
143MP0003329_amyloid_beta_deposits0.34467360
144MP0010155_abnormal_intestine_physiology0.33948756
145MP0009785_altered_susceptibility_to0.33062926
146MP0000230_abnormal_systemic_arterial0.32948631
147MP0009053_abnormal_anal_canal0.32724265
148MP0002132_abnormal_respiratory_system0.32519797
149MP0003699_abnormal_female_reproductive0.32479899
150MP0005075_abnormal_melanosome_morpholog0.32217778
151MP0000685_abnormal_immune_system0.31642751
152MP0008872_abnormal_physiological_respon0.31176822
153MP0000249_abnormal_blood_vessel0.31110140
154MP0000689_abnormal_spleen_morphology0.30945401
155MP0003172_abnormal_lysosome_physiology0.30181780

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.65918244
2Intrahepatic cholestasis (HP:0001406)6.39293611
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.97254686
4Deep venous thrombosis (HP:0002625)5.66592838
5Xanthomatosis (HP:0000991)5.44280496
6Hypobetalipoproteinemia (HP:0003563)5.42655035
7Prolonged partial thromboplastin time (HP:0003645)4.93681037
8Hyperammonemia (HP:0001987)4.56622926
9Hyperglycinuria (HP:0003108)4.52999880
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52944178
11Hyperlipoproteinemia (HP:0010980)4.35006335
12Ketosis (HP:0001946)4.27218233
13Abnormality of glycine metabolism (HP:0010895)4.25164198
14Abnormality of serine family amino acid metabolism (HP:0010894)4.25164198
15Increased serum pyruvate (HP:0003542)4.18801734
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18588276
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.17605330
18Hyperglycinemia (HP:0002154)4.14326386
19Hypoglycemic coma (HP:0001325)4.11176049
20Abnormality of pyrimidine metabolism (HP:0004353)4.08444019
21Abnormality of glycolysis (HP:0004366)3.99689178
22Complement deficiency (HP:0004431)3.98200970
23Hypolipoproteinemia (HP:0010981)3.96251447
24Joint hemorrhage (HP:0005261)3.96205806
25Abnormality of methionine metabolism (HP:0010901)3.77890635
26Fat malabsorption (HP:0002630)3.77438433
27Abnormality of fatty-acid metabolism (HP:0004359)3.69163039
28Epidermoid cyst (HP:0200040)3.68904622
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.62778673
30Abnormality of the common coagulation pathway (HP:0010990)3.61467552
31Abnormality of nucleobase metabolism (HP:0010932)3.55692430
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41132404
33Ketoacidosis (HP:0001993)3.40886732
34Abnormality of purine metabolism (HP:0004352)3.29316636
35Hypoalphalipoproteinemia (HP:0003233)3.28626601
36Gout (HP:0001997)3.24584296
37Abnormality of the intrinsic pathway (HP:0010989)3.23263502
38Hyperbilirubinemia (HP:0002904)3.19871632
39Conjugated hyperbilirubinemia (HP:0002908)3.13337340
40Generalized aminoaciduria (HP:0002909)3.10856779
41Delayed CNS myelination (HP:0002188)3.05950566
42Abnormality of serum amino acid levels (HP:0003112)3.04042440
43Hypercholesterolemia (HP:0003124)3.00982344
44Patchy hypopigmentation of hair (HP:0011365)2.96709037
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96338133
46Dicarboxylic aciduria (HP:0003215)2.96338133
47Abnormality of complement system (HP:0005339)2.95597724
48Metabolic acidosis (HP:0001942)2.90336097
49Symptomatic seizures (HP:0011145)2.87864099
50Steatorrhea (HP:0002570)2.84841754
51Abnormality of the anterior horn cell (HP:0006802)2.76480241
52Degeneration of anterior horn cells (HP:0002398)2.76480241
53Lethargy (HP:0001254)2.72882170
54Exercise-induced muscle cramps (HP:0003710)2.71992833
55Proximal tubulopathy (HP:0000114)2.71673988
56Hepatocellular carcinoma (HP:0001402)2.64776229
57Malnutrition (HP:0004395)2.62138259
58Rhabdomyolysis (HP:0003201)2.57342889
59Acute encephalopathy (HP:0006846)2.54757444
60Myoglobinuria (HP:0002913)2.46921419
61Acanthocytosis (HP:0001927)2.46706288
62Hypoglycemic seizures (HP:0002173)2.45284728
63Irritability (HP:0000737)2.44643249
64White forelock (HP:0002211)2.44245096
65Late onset (HP:0003584)2.44109217
66Spastic diplegia (HP:0001264)2.43932076
67Glycosuria (HP:0003076)2.43277675
68Abnormality of urine glucose concentration (HP:0011016)2.43277675
69Alkalosis (HP:0001948)2.43013565
70Vascular calcification (HP:0004934)2.42023734
71Myocardial infarction (HP:0001658)2.39975107
72Nausea (HP:0002018)2.39692642
73Systemic lupus erythematosus (HP:0002725)2.37794876
74Hyperuricemia (HP:0002149)2.35586970
75Increased purine levels (HP:0004368)2.35586970
76Recurrent gram-negative bacterial infections (HP:0005420)2.32207591
77Pancreatitis (HP:0001733)2.31608286
78Hypochromic microcytic anemia (HP:0004840)2.30436881
79Reduced antithrombin III activity (HP:0001976)2.30343289
80Hydroxyprolinuria (HP:0003080)2.24441204
81Abnormality of proline metabolism (HP:0010907)2.24441204
82Vomiting (HP:0002013)2.24234332
83Skin nodule (HP:0200036)2.23180195
84Metaphyseal dysplasia (HP:0100255)2.22097004
85Abnormality of vitamin metabolism (HP:0100508)2.21201909
86Microglossia (HP:0000171)2.18789962
87Cerebral edema (HP:0002181)2.18719902
88Abnormal enzyme/coenzyme activity (HP:0012379)2.17882471
89Papillary thyroid carcinoma (HP:0002895)2.15849265
90Vertebral compression fractures (HP:0002953)2.13872350
91Brushfield spots (HP:0001088)2.11623517
92Hepatic necrosis (HP:0002605)2.10802276
93Abnormality of transition element cation homeostasis (HP:0011030)2.09572323
94Sensorimotor neuropathy (HP:0007141)2.07918658
95Neonatal onset (HP:0003623)2.06071890
96Cardiovascular calcification (HP:0011915)2.04859543
97Abnormal gallbladder physiology (HP:0012438)2.04472384
98Cholecystitis (HP:0001082)2.04472384
99Abnormality of iron homeostasis (HP:0011031)2.04263842
100Abnormal gallbladder morphology (HP:0012437)2.03000359
101Hyperinsulinemic hypoglycemia (HP:0000825)2.02231376
102Opisthotonus (HP:0002179)2.01034391
103Glomerulonephritis (HP:0000099)2.01030797
104Rickets (HP:0002748)1.98994938
105Acute necrotizing encephalopathy (HP:0006965)1.98228315
106Neoplasm of the adrenal gland (HP:0100631)1.98015104
107Spontaneous abortion (HP:0005268)1.97822844
108Abnormality of alkaline phosphatase activity (HP:0004379)1.96591707
109Hypokinesia (HP:0002375)1.96496723
110Poikilocytosis (HP:0004447)1.96226915
111Spastic paraparesis (HP:0002313)1.94343307
112Type I transferrin isoform profile (HP:0003642)1.94284183
113Cholelithiasis (HP:0001081)1.94130709
114Gingival bleeding (HP:0000225)1.93921904
115Abnormal cartilage morphology (HP:0002763)1.93887682
116Renal cortical cysts (HP:0000803)1.93402079
117Methylmalonic acidemia (HP:0002912)1.92241443
118Elevated alkaline phosphatase (HP:0003155)1.91830299
119Oligomenorrhea (HP:0000876)1.91263564
120Nemaline bodies (HP:0003798)1.90211817
121Enlarged kidneys (HP:0000105)1.87509788
122Menorrhagia (HP:0000132)1.86584865
123Gonadotropin excess (HP:0000837)1.86542460
124Esophageal varix (HP:0002040)1.86174267
125Thrombophlebitis (HP:0004418)1.85073666
126Pancreatic islet-cell hyperplasia (HP:0004510)1.85034698
127Elevated hepatic transaminases (HP:0002910)1.84891508
128Progressive macrocephaly (HP:0004481)1.81604900
129Megaloblastic anemia (HP:0001889)1.81185897
130Multiple enchondromatosis (HP:0005701)1.80873794
131Mitral stenosis (HP:0001718)1.80867336
132Large for gestational age (HP:0001520)1.76825538
133Beaking of vertebral bodies (HP:0004568)1.75382204
134Abnormal mitochondria in muscle tissue (HP:0008316)1.73361194
135Thyroid carcinoma (HP:0002890)1.71407459
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70108314
137Abnormality of alanine metabolism (HP:0010916)1.70108314
138Hyperalaninemia (HP:0003348)1.70108314
139Paraparesis (HP:0002385)1.69958666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.31578668
2MST44.08131689
3TAF13.83164849
4ERN13.73070606
5TAOK33.21310627
6PDK23.01809637
7TSSK62.97584034
8FGFR42.79211025
9SIK12.56200267
10FLT32.56164149
11TESK12.37117570
12ERBB42.14190966
13EIF2AK12.10854568
14MAP4K22.08231938
15MAP3K121.98807838
16TRIM281.96684177
17WNK41.87891476
18PKN21.86944653
19TYK21.82757898
20MYLK1.79304415
21FER1.73438064
22PNCK1.72734436
23INSRR1.70553242
24ERBB31.70086425
25MAPK111.67771501
26LIMK11.65929418
27MST1R1.60440304
28GRK61.58131924
29MAP4K11.55237007
30STK161.55019155
31PLK31.51380281
32TRIB31.50199546
33ABL21.45396673
34VRK21.44467966
35NEK91.42241870
36SRPK11.39009468
37STK241.38291654
38PAK41.35863422
39ACVR1B1.35815712
40MKNK21.33598362
41PBK1.32356809
42MAP3K61.31576927
43NEK11.28717488
44WNK31.25865967
45IRAK31.25392656
46EPHA31.24515228
47TTK1.24477647
48KDR1.18347127
49STK101.16777205
50CSNK1G11.16344153
51NME21.15773388
52EEF2K1.14192912
53PTK61.10825124
54JAK21.10802243
55MAP3K101.10355416
56TBK11.10260545
57MAP2K31.07881105
58KIT1.05655885
59PIK3CG1.05080719
60STK38L1.03490384
61BMPR1B1.01103734
62AKT21.00497192
63MAP3K110.97437538
64MKNK10.97363847
65OBSCN0.95065896
66MAP3K20.94024802
67OXSR10.93888363
68CSNK1G30.93418065
69MAP3K140.93131054
70IRAK40.92524622
71CSNK1G20.91808390
72MAP3K80.91784509
73BTK0.91285385
74CCNB10.87964661
75CDK40.86942419
76MAPK150.86591942
77PRKD30.84074557
78NEK20.83219640
79BLK0.82748423
80CDK60.81916446
81NLK0.81380040
82EPHB10.80842983
83TEC0.80091286
84CSF1R0.79856362
85PLK10.78566594
86PRKAA20.78438830
87VRK10.77675072
88EIF2AK30.77450264
89TESK20.76531512
90PIM10.76102057
91MET0.75187244
92CSK0.74175329
93NTRK10.73861844
94ZAP700.73289554
95LRRK20.73138500
96WEE10.73059382
97STK390.73055856
98MAP2K20.72673483
99LATS10.72646537
100YES10.72340482
101SCYL20.69815222
102STK30.69546772
103PASK0.67602200
104JAK30.67443545
105STK40.65506539
106CASK0.63864584
107PLK20.63071649
108MAPK40.60906009
109PHKG20.60851086
110PHKG10.60851086
111CSNK1A1L0.59365969
112MAP3K30.58767578
113JAK10.56956899
114BCR0.56860626
115MAP2K40.56000074
116PRKCE0.54499977
117CDK70.54478906
118FGFR20.54321368
119PINK10.54024892
120RPS6KA40.53722572
121PIM20.53544528
122IKBKE0.51653213
123ITK0.50461004
124IGF1R0.50235368
125BUB10.49811281
126EIF2AK20.49477039
127LYN0.48021800
128CDC70.47228135
129MAPKAPK30.47175093
130CAMK2G0.46743461
131GSK3A0.46356203
132PRKAA10.46283412
133PDGFRA0.46154355
134DYRK1B0.46076861
135DAPK10.45373648
136STK380.45052076
137BRSK20.44060241
138IKBKB0.43693562
139CAMK1G0.43391091
140BRAF0.43356888
141MAP2K60.42905188
142PLK40.41809789
143ERBB20.40818918
144ILK0.38917389
145PRKACG0.38161487
146AURKB0.37995694
147ROCK20.37983448
148ALK0.37811410
149TIE10.37650183
150PDK30.36691461
151PDK40.36691461
152CAMK2D0.36351504
153MAP3K50.35695178
154FRK0.34714360
155PRKD10.34668207
156CHUK0.34272508
157FGFR10.31667700
158CSNK2A10.31529326
159ATM0.31515889
160PTK20.30313520
161EPHA20.29128081
162CDK30.28829983
163DDR20.28026074
164LMTK20.27317622

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78377601
2* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25247692
3Nitrogen metabolism_Homo sapiens_hsa009103.02078325
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77281163
5Arginine biosynthesis_Homo sapiens_hsa002202.69424953
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65354182
7* Tryptophan metabolism_Homo sapiens_hsa003802.59467231
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58843000
9* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52709664
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52298890
11* Fatty acid degradation_Homo sapiens_hsa000712.47774998
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40678962
13Peroxisome_Homo sapiens_hsa041462.19670996
14Butanoate metabolism_Homo sapiens_hsa006502.14912319
15Complement and coagulation cascades_Homo sapiens_hsa046102.13911370
16Propanoate metabolism_Homo sapiens_hsa006402.07146371
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92733697
18Fatty acid metabolism_Homo sapiens_hsa012121.84349146
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.81883905
20PPAR signaling pathway_Homo sapiens_hsa033201.79477438
21Selenocompound metabolism_Homo sapiens_hsa004501.78200756
22* Histidine metabolism_Homo sapiens_hsa003401.77883858
23Folate biosynthesis_Homo sapiens_hsa007901.76790118
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70246904
25Proteasome_Homo sapiens_hsa030501.69931271
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69899202
27* beta-Alanine metabolism_Homo sapiens_hsa004101.67566048
28Chemical carcinogenesis_Homo sapiens_hsa052041.67467978
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65340785
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.64739071
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64270931
32Caffeine metabolism_Homo sapiens_hsa002321.57961526
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55553554
34Retinol metabolism_Homo sapiens_hsa008301.51393452
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.50206884
36Sulfur metabolism_Homo sapiens_hsa009201.48681257
37* Pyruvate metabolism_Homo sapiens_hsa006201.45197685
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.44783306
39Biosynthesis of amino acids_Homo sapiens_hsa012301.39228800
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.37811199
41Staphylococcus aureus infection_Homo sapiens_hsa051501.37274141
42Phenylalanine metabolism_Homo sapiens_hsa003601.36228545
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35299032
44Fatty acid elongation_Homo sapiens_hsa000621.35140654
45Bile secretion_Homo sapiens_hsa049761.33605532
46Carbon metabolism_Homo sapiens_hsa012001.33480600
47Starch and sucrose metabolism_Homo sapiens_hsa005001.33205688
48One carbon pool by folate_Homo sapiens_hsa006701.32873341
49Fat digestion and absorption_Homo sapiens_hsa049751.30168653
50Steroid biosynthesis_Homo sapiens_hsa001001.24155257
51Vitamin digestion and absorption_Homo sapiens_hsa049771.21095822
52Tyrosine metabolism_Homo sapiens_hsa003501.19331779
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17543811
54* Arginine and proline metabolism_Homo sapiens_hsa003301.10122613
55ABC transporters_Homo sapiens_hsa020101.09310151
56Glutathione metabolism_Homo sapiens_hsa004801.02544461
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00568798
58Sulfur relay system_Homo sapiens_hsa041220.99106107
59Pentose phosphate pathway_Homo sapiens_hsa000300.98021375
60Vitamin B6 metabolism_Homo sapiens_hsa007500.94662668
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88551900
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84571558
63* Lysine degradation_Homo sapiens_hsa003100.83711935
64* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82457426
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79657767
66Oxidative phosphorylation_Homo sapiens_hsa001900.67232596
67* Glycerolipid metabolism_Homo sapiens_hsa005610.66349554
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64234777
69* Metabolic pathways_Homo sapiens_hsa011000.58899073
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57770494
71Galactose metabolism_Homo sapiens_hsa000520.55800822
72Parkinsons disease_Homo sapiens_hsa050120.52372677
73Fructose and mannose metabolism_Homo sapiens_hsa000510.49157182
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45895729
75Sphingolipid metabolism_Homo sapiens_hsa006000.44263568
76Fatty acid biosynthesis_Homo sapiens_hsa000610.42627857
77Non-homologous end-joining_Homo sapiens_hsa034500.42422589
78Vibrio cholerae infection_Homo sapiens_hsa051100.41963628
79Linoleic acid metabolism_Homo sapiens_hsa005910.37577598
80Other glycan degradation_Homo sapiens_hsa005110.32317937
81Huntingtons disease_Homo sapiens_hsa050160.29641851
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28488696
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26572446
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26403238
85Renin-angiotensin system_Homo sapiens_hsa046140.23881469
86Pyrimidine metabolism_Homo sapiens_hsa002400.23728683
87Circadian rhythm_Homo sapiens_hsa047100.23566831
88Purine metabolism_Homo sapiens_hsa002300.23488364
89Alzheimers disease_Homo sapiens_hsa050100.21322041
90DNA replication_Homo sapiens_hsa030300.20217141
91N-Glycan biosynthesis_Homo sapiens_hsa005100.19209157
92Protein export_Homo sapiens_hsa030600.18411855
93Nucleotide excision repair_Homo sapiens_hsa034200.18350034
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.17301894
95Collecting duct acid secretion_Homo sapiens_hsa049660.16636213
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.15287497
97Insulin resistance_Homo sapiens_hsa049310.14501070
98RNA degradation_Homo sapiens_hsa030180.14119504
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.12331925
100Arachidonic acid metabolism_Homo sapiens_hsa005900.07168053
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06563725
102Lysosome_Homo sapiens_hsa041420.04153779
103Prion diseases_Homo sapiens_hsa050200.02309457
104Mismatch repair_Homo sapiens_hsa034300.01128355
105Hepatitis C_Homo sapiens_hsa05160-0.1235389
106Legionellosis_Homo sapiens_hsa05134-0.1152329
107Protein digestion and absorption_Homo sapiens_hsa04974-0.1040275
108Glucagon signaling pathway_Homo sapiens_hsa04922-0.0905631
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0758113
110Homologous recombination_Homo sapiens_hsa03440-0.0618302
111Mineral absorption_Homo sapiens_hsa04978-0.0608764
112Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0583192
113Base excision repair_Homo sapiens_hsa03410-0.0373151
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0296816
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0262344
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0130552

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