ALDOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.55402011
2COPI coating of Golgi vesicle (GO:0048205)6.55402011
3glucose 6-phosphate metabolic process (GO:0051156)5.46057902
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.43232667
5tricarboxylic acid cycle (GO:0006099)5.34163129
6NADH metabolic process (GO:0006734)5.22109141
7proline biosynthetic process (GO:0006561)5.10101529
8protein maturation by protein folding (GO:0022417)4.91939286
9muscle filament sliding (GO:0030049)4.88809839
10actin-myosin filament sliding (GO:0033275)4.88809839
11synaptic vesicle exocytosis (GO:0016079)4.69042807
12pentose-phosphate shunt (GO:0006098)4.48641591
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42156881
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.38199458
15regulation of translational fidelity (GO:0006450)4.32176886
16glutamate secretion (GO:0014047)4.30761289
17regulation of coenzyme metabolic process (GO:0051196)4.27102498
18regulation of cofactor metabolic process (GO:0051193)4.27102498
194-hydroxyproline metabolic process (GO:0019471)4.27061117
20* glycolytic process (GO:0006096)4.23155965
21NADPH regeneration (GO:0006740)4.22479027
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20294940
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14975907
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11559973
25ATP hydrolysis coupled proton transport (GO:0015991)4.11205478
26energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.11205478
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.10416684
28sarcomere organization (GO:0045214)4.08639796
29regulation of acyl-CoA biosynthetic process (GO:0050812)4.08251791
30oxaloacetate metabolic process (GO:0006107)4.05488521
31synaptic vesicle maturation (GO:0016188)4.01869851
32peptidyl-proline hydroxylation (GO:0019511)3.99042792
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.96771897
34cardiac muscle contraction (GO:0060048)3.96710717
35protein retention in ER lumen (GO:0006621)3.94962205
36cardiac myofibril assembly (GO:0055003)3.94738994
37glucose catabolic process (GO:0006007)3.86102659
38regulation of synaptic vesicle exocytosis (GO:2000300)3.85879517
39actin-mediated cell contraction (GO:0070252)3.84375195
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.79674614
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.75411568
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70180243
43* gluconeogenesis (GO:0006094)3.67895573
44nucleobase-containing small molecule interconversion (GO:0015949)3.66681344
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.63932791
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.62961931
47cell communication by electrical coupling (GO:0010644)3.56443873
48protein hydroxylation (GO:0018126)3.56303988
49neuronal action potential propagation (GO:0019227)3.55424602
50transferrin transport (GO:0033572)3.55187835
51myofibril assembly (GO:0030239)3.54376944
52formation of translation preinitiation complex (GO:0001731)3.54043444
53vocalization behavior (GO:0071625)3.48777719
54oxidative phosphorylation (GO:0006119)3.47925035
55regulation of synaptic vesicle transport (GO:1902803)3.45762970
56plasma membrane repair (GO:0001778)3.44470706
57* striated muscle contraction (GO:0006941)3.43857801
58regulation of mitotic spindle organization (GO:0060236)3.43284738
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43064892
60regulation of early endosome to late endosome transport (GO:2000641)3.42537962
61DNA unwinding involved in DNA replication (GO:0006268)3.42423415
62regulation of glutamate receptor signaling pathway (GO:1900449)3.40180369
63regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.39173901
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38146861
65tricarboxylic acid metabolic process (GO:0072350)3.35516353
66regulation of skeletal muscle contraction (GO:0014819)3.35358526
67neurotransmitter secretion (GO:0007269)3.34872946
68regulation of cell communication by electrical coupling (GO:0010649)3.32610054
69* hexose biosynthetic process (GO:0019319)3.32347962
70creatine metabolic process (GO:0006600)3.32021521
71positive regulation of synapse maturation (GO:0090129)3.32006735
72regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31034726
73peptidyl-arginine omega-N-methylation (GO:0035247)3.31034131
74sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30224153
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28689679
76proline metabolic process (GO:0006560)3.28538340
77ferric iron transport (GO:0015682)3.26897638
78trivalent inorganic cation transport (GO:0072512)3.26897638
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25788580
80mitotic chromosome condensation (GO:0007076)3.25644915
81negative regulation of potassium ion transmembrane transport (GO:1901380)3.22216560
82mitotic nuclear envelope reassembly (GO:0007084)3.21532300
83nuclear envelope reassembly (GO:0031468)3.21532300
84tRNA aminoacylation for protein translation (GO:0006418)3.20188935
85activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.19791843
86activation of protein kinase A activity (GO:0034199)3.19268135
87sodium ion export (GO:0071436)3.17779964
88positive regulation of nuclease activity (GO:0032075)3.15623905
89vesicle coating (GO:0006901)3.13015257
90succinate metabolic process (GO:0006105)3.12934576
91protein localization to synapse (GO:0035418)3.11590164
92locomotory exploration behavior (GO:0035641)3.09563427
93regulation of membrane repolarization (GO:0060306)3.08956165
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07896081
95regulation of synapse structural plasticity (GO:0051823)3.07874788
96* pyruvate metabolic process (GO:0006090)3.06941551
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06844934
98regulation of sodium ion transmembrane transporter activity (GO:2000649)3.04467520
99IMP biosynthetic process (GO:0006188)3.01654883
100* monosaccharide biosynthetic process (GO:0046364)3.01610555
101tRNA aminoacylation (GO:0043039)3.00453418
102amino acid activation (GO:0043038)3.00453418
103GDP-mannose metabolic process (GO:0019673)3.00343763
104regulation of calcium ion transmembrane transport (GO:1903169)2.97719628
105regulation of calcium ion transmembrane transporter activity (GO:1901019)2.97719628
106cell communication involved in cardiac conduction (GO:0086065)2.97606363
107mitotic sister chromatid segregation (GO:0000070)2.97536954
108ATP synthesis coupled proton transport (GO:0015986)2.96650058
109energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96650058
110IMP metabolic process (GO:0046040)2.96573179
111cellular potassium ion homeostasis (GO:0030007)2.95347149
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95208862
113establishment of integrated proviral latency (GO:0075713)2.91642616
114neurotransmitter-gated ion channel clustering (GO:0072578)2.91214022
115nucleoside diphosphate biosynthetic process (GO:0009133)2.90621363
116regulation of relaxation of muscle (GO:1901077)2.89975660
117* glucose metabolic process (GO:0006006)2.89293038
118cardiac conduction (GO:0061337)2.88675218
119DNA strand elongation involved in DNA replication (GO:0006271)2.88057370
120regulation of translational termination (GO:0006449)2.87913384
121actomyosin structure organization (GO:0031032)2.85856012
122membrane depolarization during action potential (GO:0086010)2.85166833
123regulation of voltage-gated calcium channel activity (GO:1901385)2.85114912
124negative regulation of potassium ion transport (GO:0043267)2.84522542
125regulation of heart rate by cardiac conduction (GO:0086091)2.84365980
126negative regulation of dendrite morphogenesis (GO:0050774)2.84278874
127cardiac muscle cell action potential involved in contraction (GO:0086002)2.82821118
128cardiac muscle hypertrophy (GO:0003300)2.81145194
129neuron-neuron synaptic transmission (GO:0007270)2.80864560
130regulation of nuclease activity (GO:0032069)2.80835551
131cardiac muscle cell action potential (GO:0086001)2.80588539
132negative regulation of cation channel activity (GO:2001258)2.80214402
133DNA strand elongation (GO:0022616)2.79730864
134actin filament-based movement (GO:0030048)2.79546378
135negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78915856
136endoplasmic reticulum unfolded protein response (GO:0030968)2.78837686
137regulation of sodium ion transmembrane transport (GO:1902305)2.77784965
138regulation of potassium ion transmembrane transporter activity (GO:1901016)2.75966924
139* single-organism carbohydrate catabolic process (GO:0044724)2.75735601
140regulation of protein kinase A signaling (GO:0010738)2.75679863
141melanin biosynthetic process (GO:0042438)2.74222023
142ribosome assembly (GO:0042255)2.72141791
143regulation of ion transmembrane transporter activity (GO:0032412)2.72045025
144mitochondrial genome maintenance (GO:0000002)2.71972017
145positive regulation of sodium ion transport (GO:0010765)2.71924414
146establishment of viral latency (GO:0019043)2.71281000
147pinocytosis (GO:0006907)2.71187669
148striated muscle hypertrophy (GO:0014897)2.70976851
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70451387
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70260175
151long-term synaptic potentiation (GO:0060291)2.69465458
152ER-nucleus signaling pathway (GO:0006984)2.67519053
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66263668
154spliceosomal tri-snRNP complex assembly (GO:0000244)2.65195949
155negative regulation of ligase activity (GO:0051352)2.63282489
156negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63282489
157regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61329252
158regulation of spindle organization (GO:0090224)2.60996458
159negative regulation of cell size (GO:0045792)2.59427964
160regulation of translational elongation (GO:0006448)2.59363066
161cellular response to unfolded protein (GO:0034620)2.58782818
162barbed-end actin filament capping (GO:0051016)2.58568760
163regulation of cellular amino acid metabolic process (GO:0006521)2.57887110
164galactose catabolic process (GO:0019388)2.57391972
165telomere maintenance via semi-conservative replication (GO:0032201)2.56892404
166peptidyl-arginine methylation (GO:0018216)2.56449699
167peptidyl-arginine N-methylation (GO:0035246)2.56449699
168protein complex localization (GO:0031503)2.56213655
169positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56110045
170endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.55127814
171glutamine family amino acid biosynthetic process (GO:0009084)2.53909281
172COPII vesicle coating (GO:0048208)2.53908865
173L-serine metabolic process (GO:0006563)2.52885372
174histone arginine methylation (GO:0034969)2.52175669
175mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.51977610
176mitotic nuclear envelope disassembly (GO:0007077)2.51174398
177* carbohydrate catabolic process (GO:0016052)2.50879559
178proteasome assembly (GO:0043248)2.50528610
179* hexose metabolic process (GO:0019318)2.49847287
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.49202296
181regulation of cholesterol biosynthetic process (GO:0045540)2.48916428
182protein export from nucleus (GO:0006611)2.48689200
183* carbohydrate biosynthetic process (GO:0016051)2.48291855
184deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47390279
185mitochondrial fusion (GO:0008053)2.47028443
186sister chromatid segregation (GO:0000819)2.45474242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.85477069
2EZH2_22144423_ChIP-Seq_EOC_Human4.10562999
3E2F7_22180533_ChIP-Seq_HELA_Human3.99937352
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.56955495
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78046820
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.70141770
7GBX2_23144817_ChIP-Seq_PC3_Human2.63338549
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55698201
9* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52944271
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.48523335
11REST_21632747_ChIP-Seq_MESCs_Mouse2.39401666
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32412525
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31529513
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28679415
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.26421877
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25533626
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19910958
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14117715
19* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12925867
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08489330
21* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.05892256
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03469483
23* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03238719
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01769891
25* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01490766
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00402369
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96219935
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93370356
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93359915
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90662176
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89108399
32XRN2_22483619_ChIP-Seq_HELA_Human1.87747681
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.86276556
34CLOCK_20551151_ChIP-Seq_293T_Human1.85848508
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82960030
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81555722
37* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80209489
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79096557
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.79089945
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78158929
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77407333
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76531900
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73228732
44RACK7_27058665_Chip-Seq_MCF-7_Human1.73074312
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70416393
46* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.68396378
47DCP1A_22483619_ChIP-Seq_HELA_Human1.65979577
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65257965
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65257965
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64707099
51MYC_22102868_ChIP-Seq_BL_Human1.63847462
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63756214
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63557518
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63448679
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62947987
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61885600
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61514598
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.61189775
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.59049593
60DROSHA_22980978_ChIP-Seq_HELA_Human1.58340406
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57274920
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56778136
63* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56351622
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56148654
65* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55031086
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54491248
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53039229
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50986938
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50163245
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46162608
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45491395
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45236385
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.44522571
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43927575
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42887963
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42837447
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42236332
78ZNF263_19887448_ChIP-Seq_K562_Human1.41477113
79* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40841311
80* GABP_19822575_ChIP-Seq_HepG2_Human1.40048179
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37610392
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35878934
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35775653
84* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34439350
85AR_21909140_ChIP-Seq_LNCAP_Human1.34140731
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32556220
87ZNF274_21170338_ChIP-Seq_K562_Hela1.31899413
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31766681
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.30583257
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30372168
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29791036
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28372797
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.27283153
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.25638144
95* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25304607
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.25052896
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23413028
98* VDR_21846776_ChIP-Seq_THP-1_Human1.23372708
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21883623
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21524090
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19186933
102* NCOR1_26117541_ChIP-Seq_K562_Human1.18583547
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16754671
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16403821
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16094112
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14816375
107* ATF3_27146783_Chip-Seq_COLON_Human1.14476316
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.14385302
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14154513
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14052680
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13433380
112* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12602161
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11715669
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.11658848
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.11541505
116P68_20966046_ChIP-Seq_HELA_Human1.11266064
117TFEB_21752829_ChIP-Seq_HELA_Human1.11171197
118SMAD4_21799915_ChIP-Seq_A2780_Human1.10406135
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10313022
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09426366
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07516034
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07449487
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07160689
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06977498
125* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05551846
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05512685
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05022559
128KDM5A_27292631_Chip-Seq_BREAST_Human1.04937827
129CTCF_27219007_Chip-Seq_Bcells_Human1.03615211
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02894278
131CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02754469
132AR_19668381_ChIP-Seq_PC3_Human1.01362832
133SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01336333
134* TTF2_22483619_ChIP-Seq_HELA_Human1.01192665
135GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00511102
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.00079937
137* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99450626
138OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98636953
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98397089
140* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98287723
141* E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98181219
142SMAD4_21741376_ChIP-Seq_ESCs_Human0.98064406
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96781552
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95102395
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94782820
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94673598
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94527860
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.94437032
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.94437032
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92721001
151MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92439963
152KDM2B_26808549_Chip-Seq_K562_Human0.91695831
153* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91637780
154FOXH1_21741376_ChIP-Seq_ESCs_Human0.91039038
155* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90657957
156ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89968155
157ETS1_20019798_ChIP-Seq_JURKAT_Human0.85522512
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85196402
159YY1_21170310_ChIP-Seq_MESCs_Mouse0.84994447
160* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84615390
161EOMES_21245162_ChIP-Seq_HESCs_Human0.84559554
162ELF1_20517297_ChIP-Seq_JURKAT_Human0.84348375
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83511048
164SMC4_20622854_ChIP-Seq_HELA_Human0.82937366
165* LXR_22292898_ChIP-Seq_THP-1_Human0.81875375
166AR_25329375_ChIP-Seq_VCAP_Human0.81746597
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81570830
168BCL6_27268052_Chip-Seq_Bcells_Human0.81464175
169OCT4_19829295_ChIP-Seq_ESCs_Human0.81267630
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81112222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.10388984
2MP0005451_abnormal_body_composition3.81049394
3MP0002837_dystrophic_cardiac_calcinosis3.79595571
4MP0000751_myopathy3.64397923
5MP0003646_muscle_fatigue3.53060752
6MP0004084_abnormal_cardiac_muscle3.50388127
7MP0002877_abnormal_melanocyte_morpholog3.43647956
8MP0000749_muscle_degeneration3.26672949
9MP0004036_abnormal_muscle_relaxation3.02122727
10MP0008260_abnormal_autophagy2.84379252
11MP0010234_abnormal_vibrissa_follicle2.83468509
12MP0003880_abnormal_central_pattern2.82421999
13MP0008438_abnormal_cutaneous_collagen2.67505707
14MP0003635_abnormal_synaptic_transmissio2.66400584
15MP0000372_irregular_coat_pigmentation2.61910300
16MP0003705_abnormal_hypodermis_morpholog2.55411013
17MP0004145_abnormal_muscle_electrophysio2.50632070
18MP0005058_abnormal_lysosome_morphology2.45289778
19MP0004215_abnormal_myocardial_fiber2.43590497
20MP0003806_abnormal_nucleotide_metabolis2.42429785
21MP0004270_analgesia2.42187895
22MP0009046_muscle_twitch2.40891210
23MP0003111_abnormal_nucleus_morphology2.33110487
24MP0005171_absent_coat_pigmentation2.32071520
25MP0004233_abnormal_muscle_weight2.30304311
26MP0002064_seizures2.26807499
27MP0009745_abnormal_behavioral_response2.24589434
28MP0001968_abnormal_touch/_nociception2.21197089
29MP0002736_abnormal_nociception_after2.14893314
30MP0002822_catalepsy2.12753906
31MP0002063_abnormal_learning/memory/cond2.08394049
32MP0000747_muscle_weakness2.06674665
33MP0004957_abnormal_blastocyst_morpholog2.02467403
34MP0005620_abnormal_muscle_contractility2.01768113
35MP0004087_abnormal_muscle_fiber1.98730428
36MP0009780_abnormal_chondrocyte_physiolo1.97467617
37MP0002269_muscular_atrophy1.95055554
38MP0002972_abnormal_cardiac_muscle1.93773997
39MP0003122_maternal_imprinting1.92256431
40MP0004484_altered_response_of1.91165438
41MP0002106_abnormal_muscle_physiology1.89456160
42MP0004272_abnormal_basement_membrane1.80860338
43MP0002909_abnormal_adrenal_gland1.77429570
44MP0008932_abnormal_embryonic_tissue1.77119758
45MP0005330_cardiomyopathy1.76761853
46MP0005408_hypopigmentation1.76406416
47MP0002734_abnormal_mechanical_nocicepti1.75406641
48MP0004858_abnormal_nervous_system1.72307513
49MP0010094_abnormal_chromosome_stability1.69401671
50MP0003693_abnormal_embryo_hatching1.67230695
51MP0002735_abnormal_chemical_nociception1.66803728
52MP0002572_abnormal_emotion/affect_behav1.66096249
53MP0003123_paternal_imprinting1.65635331
54MP0002272_abnormal_nervous_system1.64767652
55MP0000759_abnormal_skeletal_muscle1.64436427
56MP0008775_abnormal_heart_ventricle1.64421165
57MP0004130_abnormal_muscle_cell1.63997016
58MP0003077_abnormal_cell_cycle1.57886629
59MP0000678_abnormal_parathyroid_gland1.55323724
60MP0005369_muscle_phenotype1.53504916
61MP0008007_abnormal_cellular_replicative1.52354943
62MP0000750_abnormal_muscle_regeneration1.51346119
63MP0001440_abnormal_grooming_behavior1.49367248
64MP0002332_abnormal_exercise_endurance1.46809271
65MP0001730_embryonic_growth_arrest1.46558285
66MP0004085_abnormal_heartbeat1.45164777
67MP0001501_abnormal_sleep_pattern1.44449773
68MP0009840_abnormal_foam_cell1.44418785
69MP0000003_abnormal_adipose_tissue1.44405500
70MP0006138_congestive_heart_failure1.44319274
71MP0001849_ear_inflammation1.41081579
72MP0006036_abnormal_mitochondrial_physio1.37475165
73MP0004510_myositis1.35930720
74MP0003221_abnormal_cardiomyocyte_apopto1.35002860
75MP0005257_abnormal_intraocular_pressure1.34720331
76MP0005385_cardiovascular_system_phenoty1.34034561
77MP0001544_abnormal_cardiovascular_syste1.34034561
78MP0000358_abnormal_cell_content/1.33522686
79MP0000013_abnormal_adipose_tissue1.33045310
80MP0009672_abnormal_birth_weight1.31865963
81MP0003879_abnormal_hair_cell1.29974900
82MP0002067_abnormal_sensory_capabilities1.28247017
83MP0003191_abnormal_cellular_cholesterol1.26679649
84MP0008569_lethality_at_weaning1.26311461
85MP0003329_amyloid_beta_deposits1.23653680
86MP0003137_abnormal_impulse_conducting1.22974094
87MP0003950_abnormal_plasma_membrane1.22431246
88MP0001970_abnormal_pain_threshold1.21870287
89MP0001529_abnormal_vocalization1.20669275
90MP0005386_behavior/neurological_phenoty1.18708432
91MP0004924_abnormal_behavior1.18708432
92MP0002080_prenatal_lethality1.18218317
93MP0005165_increased_susceptibility_to1.16330392
94MP0002733_abnormal_thermal_nociception1.16212784
95MP0010030_abnormal_orbit_morphology1.15764918
96MP0001661_extended_life_span1.14913580
97MP0003186_abnormal_redox_activity1.14206942
98MP0000350_abnormal_cell_proliferation1.13323372
99MP0004811_abnormal_neuron_physiology1.12026880
100MP0010630_abnormal_cardiac_muscle1.09405218
101MP0003787_abnormal_imprinting1.08432285
102MP0005375_adipose_tissue_phenotype1.07517503
103MP0005083_abnormal_biliary_tract1.07348905
104MP0005501_abnormal_skin_physiology1.07122208
105MP0002796_impaired_skin_barrier1.05240128
106MP0004381_abnormal_hair_follicle1.04600694
107MP0003786_premature_aging1.03696806
108MP0002060_abnormal_skin_morphology1.02839039
109MP0005670_abnormal_white_adipose1.01915452
110MP0005666_abnormal_adipose_tissue1.00871711
111MP0006035_abnormal_mitochondrial_morpho0.99178807
112MP0001486_abnormal_startle_reflex0.98168359
113MP0002653_abnormal_ependyma_morphology0.97103205
114MP0005076_abnormal_cell_differentiation0.96691102
115MP0002184_abnormal_innervation0.94331647
116MP0004185_abnormal_adipocyte_glucose0.94323022
117MP0005384_cellular_phenotype0.92821691
118MP0003453_abnormal_keratinocyte_physiol0.92682315
119MP0002066_abnormal_motor_capabilities/c0.91717037
120MP0002127_abnormal_cardiovascular_syste0.90996046
121MP0005621_abnormal_cell_physiology0.90756765
122MP0001697_abnormal_embryo_size0.89211128
123MP0008872_abnormal_physiological_respon0.84539706
124MP0005380_embryogenesis_phenotype0.84402267
125MP0001672_abnormal_embryogenesis/_devel0.84402267
126MP0000733_abnormal_muscle_development0.83043508
127MP0005584_abnormal_enzyme/coenzyme_acti0.82215798
128MP0000015_abnormal_ear_pigmentation0.81520464
129MP0003011_delayed_dark_adaptation0.81353017
130MP0003121_genomic_imprinting0.79762333
131MP0004264_abnormal_extraembryonic_tissu0.78834950
132MP0000313_abnormal_cell_death0.77668085
133MP0004043_abnormal_pH_regulation0.77610071
134MP0005551_abnormal_eye_electrophysiolog0.76670006
135MP0003984_embryonic_growth_retardation0.76497215
136MP0002075_abnormal_coat/hair_pigmentati0.76187388
137MP0005623_abnormal_meninges_morphology0.76181801
138MP0005266_abnormal_metabolism0.75712109
139MP0000858_altered_metastatic_potential0.74221751
140MP0002089_abnormal_postnatal_growth/wei0.73967110
141MP0002882_abnormal_neuron_morphology0.73816698
142MP0000371_diluted_coat_color0.73525084
143MP0008877_abnormal_DNA_methylation0.72920761
144MP0003566_abnormal_cell_adhesion0.72710943
145MP0002090_abnormal_vision0.70279813
146MP0001905_abnormal_dopamine_level0.70234893
147MP0008058_abnormal_DNA_repair0.69899620
148MP0001348_abnormal_lacrimal_gland0.69663136
149MP0002088_abnormal_embryonic_growth/wei0.69514483
150MP0002970_abnormal_white_adipose0.69112942
151MP0003633_abnormal_nervous_system0.69037583
152MP0001186_pigmentation_phenotype0.68080591
153MP0002234_abnormal_pharynx_morphology0.67990029
154MP0002557_abnormal_social/conspecific_i0.67794846
155MP0006276_abnormal_autonomic_nervous0.66653628
156MP0005423_abnormal_somatic_nervous0.65799619
157MP0004142_abnormal_muscle_tone0.65325180
158MP0000955_abnormal_spinal_cord0.65181984
159MP0002638_abnormal_pupillary_reflex0.64560334
160MP0003631_nervous_system_phenotype0.63020664
161MP0002229_neurodegeneration0.62724030
162MP0003172_abnormal_lysosome_physiology0.61637620
163MP0008874_decreased_physiological_sensi0.59309903
164MP0005646_abnormal_pituitary_gland0.58804533
165MP0000343_altered_response_to0.56627652
166MP0005535_abnormal_body_temperature0.54868686

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.71752436
2* Abnormal gallbladder physiology (HP:0012438)6.01856046
3* Cholecystitis (HP:0001082)6.01856046
4Exercise-induced myalgia (HP:0003738)5.37610403
5Focal motor seizures (HP:0011153)4.75987953
6Myoglobinuria (HP:0002913)4.30295500
7Calf muscle hypertrophy (HP:0008981)4.14867012
8Sudden death (HP:0001699)4.14165615
9Muscle hypertrophy of the lower extremities (HP:0008968)4.07662921
10Myokymia (HP:0002411)3.69586358
11Pheochromocytoma (HP:0002666)3.65970996
12Abnormality of the calf musculature (HP:0001430)3.50116979
13Visual hallucinations (HP:0002367)3.46012037
14EMG: myopathic abnormalities (HP:0003458)3.43341914
15Atonic seizures (HP:0010819)3.38247884
16Neuroendocrine neoplasm (HP:0100634)3.36925938
17Muscle fiber inclusion bodies (HP:0100299)3.33334512
18Rhabdomyolysis (HP:0003201)3.32871453
19Epileptic encephalopathy (HP:0200134)3.29822907
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.28828906
21Increased serum pyruvate (HP:0003542)3.20967107
22Abnormality of glycolysis (HP:0004366)3.20967107
23Myotonia (HP:0002486)3.17796862
24Focal seizures (HP:0007359)3.13416912
25Hyporeflexia of lower limbs (HP:0002600)3.13341189
26Type 1 muscle fiber predominance (HP:0003803)3.08730929
27Dysmetric saccades (HP:0000641)3.03328755
28Nemaline bodies (HP:0003798)3.01749404
29Reticulocytosis (HP:0001923)2.95679986
30Resting tremor (HP:0002322)2.95395724
31Abnormal mitochondria in muscle tissue (HP:0008316)2.94111638
32* Cholelithiasis (HP:0001081)2.91972557
33Oligomenorrhea (HP:0000876)2.91356871
34Muscle stiffness (HP:0003552)2.89117879
35Distal upper limb amyotrophy (HP:0007149)2.87643679
36Upper limb amyotrophy (HP:0009129)2.87643679
37Palpitations (HP:0001962)2.87329362
38Absence seizures (HP:0002121)2.80009711
39Atrial fibrillation (HP:0005110)2.79452727
40Acute necrotizing encephalopathy (HP:0006965)2.75002246
41Distal arthrogryposis (HP:0005684)2.73080905
42Febrile seizures (HP:0002373)2.70419583
43Premature rupture of membranes (HP:0001788)2.70336537
44Subaortic stenosis (HP:0001682)2.70335643
45Abnormality of the left ventricular outflow tract (HP:0011103)2.70335643
46Generalized tonic-clonic seizures (HP:0002069)2.69552168
47Primary atrial arrhythmia (HP:0001692)2.69184955
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.68638661
49Muscle fiber splitting (HP:0003555)2.67370855
50Supraventricular tachycardia (HP:0004755)2.61956650
51Ventricular tachycardia (HP:0004756)2.59393932
52Progressive muscle weakness (HP:0003323)2.57519732
53Supraventricular arrhythmia (HP:0005115)2.55378088
54Difficulty running (HP:0009046)2.54079887
55Asymmetric septal hypertrophy (HP:0001670)2.54051771
56Bundle branch block (HP:0011710)2.54018175
57* Abnormal gallbladder morphology (HP:0012437)2.53233816
58Abnormality of the lower motor neuron (HP:0002366)2.51737717
59Dialeptic seizures (HP:0011146)2.51096806
60Neoplasm of the peripheral nervous system (HP:0100007)2.50641260
61Hand muscle atrophy (HP:0009130)2.49915090
62Lower limb amyotrophy (HP:0007210)2.46481646
63Increased connective tissue (HP:0009025)2.46049158
64Exercise intolerance (HP:0003546)2.41378149
65Syncope (HP:0001279)2.40257760
66Right ventricular cardiomyopathy (HP:0011663)2.38144308
67Ventricular fibrillation (HP:0001663)2.37591848
68Achilles tendon contracture (HP:0001771)2.37045663
69Hyperacusis (HP:0010780)2.36537078
70Neck muscle weakness (HP:0000467)2.35548481
71Mildly elevated creatine phosphokinase (HP:0008180)2.34109496
72Shoulder girdle muscle weakness (HP:0003547)2.32983087
73Vertebral compression fractures (HP:0002953)2.32727771
74Ventricular arrhythmia (HP:0004308)2.32480131
75Upper limb muscle weakness (HP:0003484)2.32392259
76Difficulty climbing stairs (HP:0003551)2.28568285
77Myopathic facies (HP:0002058)2.28359456
78Progressive macrocephaly (HP:0004481)2.27513308
79Insomnia (HP:0100785)2.27329658
80Ulnar deviation of the wrist (HP:0003049)2.27166152
81Increased CSF lactate (HP:0002490)2.26977120
82Mitochondrial inheritance (HP:0001427)2.26572210
83Impaired vibration sensation in the lower limbs (HP:0002166)2.26186703
84Failure to thrive in infancy (HP:0001531)2.25914156
85Left ventricular hypertrophy (HP:0001712)2.25749665
86Poor eye contact (HP:0000817)2.23647078
87Abnormality of skeletal muscle fiber size (HP:0012084)2.23169440
88Lipoatrophy (HP:0100578)2.22345018
89Hypokinesia (HP:0002375)2.21374472
90Conjunctival hamartoma (HP:0100780)2.19895407
91Hepatocellular necrosis (HP:0001404)2.18299217
92Increased variability in muscle fiber diameter (HP:0003557)2.18010055
93Trismus (HP:0000211)2.17285203
94Spinal rigidity (HP:0003306)2.15825991
95Central scotoma (HP:0000603)2.14370909
96Round ear (HP:0100830)2.13121200
97* Abnormality of the gallbladder (HP:0005264)2.12769440
98EMG: neuropathic changes (HP:0003445)2.11474005
99Abnormality of the Achilles tendon (HP:0005109)2.11267985
100Unsteady gait (HP:0002317)2.11193932
101Generalized amyotrophy (HP:0003700)2.10817271
102Prolonged QT interval (HP:0001657)2.10702999
103Distal lower limb muscle weakness (HP:0009053)2.10687692
104Ragged-red muscle fibers (HP:0003200)2.10403285
105Foot dorsiflexor weakness (HP:0009027)2.09046106
106Emotional lability (HP:0000712)2.06459663
107Depression (HP:0000716)2.05657887
108Abnormality of reticulocytes (HP:0004312)2.05600297
109Breech presentation (HP:0001623)2.04095297
110Stridor (HP:0010307)2.02751695
111Rimmed vacuoles (HP:0003805)2.01528970
112Abnormality of pain sensation (HP:0010832)1.99968804
113Impaired pain sensation (HP:0007328)1.99968804
114Cerebral hypomyelination (HP:0006808)1.99477671
115Abnormal social behavior (HP:0012433)1.99346403
116Impaired social interactions (HP:0000735)1.99346403
117Dysdiadochokinesis (HP:0002075)1.99195831
118Abnormal EKG (HP:0003115)1.97730859
119Progressive cerebellar ataxia (HP:0002073)1.96211260
120Frequent falls (HP:0002359)1.95371986
121Urinary urgency (HP:0000012)1.94457371
122Acute encephalopathy (HP:0006846)1.94348320
123Diaphragmatic weakness (HP:0009113)1.93114602
124Limb-girdle muscle atrophy (HP:0003797)1.92999042
125Distal lower limb amyotrophy (HP:0008944)1.91419390
126Abnormality of the vocal cords (HP:0008777)1.91395350
127Abnormality of the foot musculature (HP:0001436)1.90779949
128Areflexia of lower limbs (HP:0002522)1.89545201
129Hypercortisolism (HP:0001578)1.88795449
130Axonal loss (HP:0003447)1.87632853
131Fetal akinesia sequence (HP:0001989)1.86276585
132Microvesicular hepatic steatosis (HP:0001414)1.86028392
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85970542
134Progressive external ophthalmoplegia (HP:0000590)1.82169840
135Impaired proprioception (HP:0010831)1.79904440
136Microglossia (HP:0000171)1.77715978
137Long palpebral fissure (HP:0000637)1.75803317
138Truncus arteriosus (HP:0001660)1.74788835
139Easy fatigability (HP:0003388)1.71754795
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70362753
141Abnormality of the umbilical cord (HP:0010881)1.70053227
142Nuclear cataract (HP:0100018)1.69158517
143Reduced subcutaneous adipose tissue (HP:0003758)1.68709296
144Distal sensory impairment (HP:0002936)1.67801315
145Abnormality of the tricuspid valve (HP:0001702)1.66562653
146Gout (HP:0001997)1.65218087
147Orthostatic hypotension (HP:0001278)1.64851024
148Hyperthyroidism (HP:0000836)1.62979191
149J-shaped sella turcica (HP:0002680)1.62947938
150Fatigue (HP:0012378)1.61999917
151Calcaneovalgus deformity (HP:0001848)1.60327097
152Ankyloglossia (HP:0010296)1.59821437
153Abnormalities of placenta or umbilical cord (HP:0001194)1.58730915
154Cerebral aneurysm (HP:0004944)1.57371848
155Protrusio acetabuli (HP:0003179)1.56551935
156Bulbar palsy (HP:0001283)1.56334844
157Increased nuchal translucency (HP:0010880)1.56210858
158Rough bone trabeculation (HP:0100670)1.55326829
159Back pain (HP:0003418)1.55265925
160Slender build (HP:0001533)1.54980587
161Hammertoe (HP:0001765)1.54934661
162Testicular atrophy (HP:0000029)1.52066679
163Pterygium (HP:0001059)1.51817308
164Elbow flexion contracture (HP:0002987)1.51203919
165Fasciculations (HP:0002380)1.51137371
166Hypertensive crisis (HP:0100735)1.50406272
167Tetraplegia (HP:0002445)1.50098300
168Type I transferrin isoform profile (HP:0003642)1.50004024
169Postnatal microcephaly (HP:0005484)1.49653330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.72410603
2OBSCN3.45147157
3MAP3K123.34582469
4NME23.08888013
5MAP3K92.96328155
6EIF2AK12.85269751
7BUB12.75527572
8SMG12.74830691
9NTRK32.71058829
10PDK32.52526047
11PDK42.52526047
12MAP3K42.49183988
13EEF2K2.43136097
14CASK2.42094532
15IRAK32.35111835
16ARAF2.21250470
17VRK22.14491879
18MYLK2.14243304
19ICK2.09906329
20TSSK62.09660302
21EPHA42.05355082
22DAPK11.99157073
23TTN1.97533537
24KSR21.93372998
25DAPK21.92209225
26MAP2K41.89325999
27NME11.88917048
28MINK11.88778275
29PLK21.87655485
30PKN21.87620413
31PHKG21.73283496
32PHKG11.73283496
33PAK41.68366129
34BCKDK1.67455581
35MST1R1.66463834
36CDK191.65166359
37TESK21.62750672
38MAP2K71.62002626
39SIK11.55790670
40PDK21.55031918
41DAPK31.46379122
42PRKD31.42165706
43PBK1.40808278
44LMTK21.36754987
45CCNB11.33954389
46ERN11.32432826
47PRPF4B1.28760897
48TTK1.28375851
49WEE11.25432550
50KSR11.23132836
51AKT31.22801704
52PTK2B1.20968540
53FGFR41.20715024
54TAOK21.18980350
55TRIB31.18917588
56LIMK11.16063563
57PAK61.14831537
58PTK21.10934076
59MAP3K81.10691423
60GRK51.08920153
61LATS21.03188023
62TESK11.02454459
63CAMKK10.97817344
64RPS6KB20.95872601
65STK380.92999301
66AKT20.92670898
67MAP2K10.92137375
68STK240.88336180
69RIPK40.86763148
70MAP3K130.86312270
71BRAF0.86154592
72PAK10.83705140
73EPHA20.81117369
74PRKCG0.81002742
75NTRK10.80731130
76EPHB10.80039209
77CDK180.77329757
78CAMKK20.77008262
79CDK140.75560756
80CDK50.74924593
81RAF10.74858518
82SGK2230.74521346
83SGK4940.74521346
84CAMK2A0.72084218
85CAMK10.71121611
86CDK150.70758332
87CDK70.70686254
88ALK0.70590808
89FER0.70576541
90MOS0.70110922
91MAP3K50.68720319
92PRKCH0.68137339
93SIK30.67765144
94MET0.66295019
95SCYL20.65903083
96SGK30.65295419
97MAPK110.64799957
98FLT30.61708773
99CAMK2D0.61077060
100SRPK10.60893201
101SGK20.60716290
102STK38L0.60222868
103LRRK20.60167005
104ILK0.60045335
105MAP3K110.60043924
106AURKA0.57948932
107CDK11A0.57803803
108BRSK10.57581049
109FGFR10.56186759
110MAP3K10.54408608
111BMX0.54387456
112PINK10.54251405
113TAOK10.54195818
114DMPK0.53585988
115CLK10.53374106
116RIPK10.52934923
117MAP2K30.52392954
118PTK60.51553979
119PDK10.51003730
120CAMK2G0.50738330
121MAP3K70.50044752
122MAP3K20.49585931
123CAMK2B0.49109787
124RET0.48514325
125MTOR0.48314424
126MAPKAPK50.47899445
127STK100.45338127
128EIF2AK30.44935334
129CDC42BPA0.44573678
130CDK120.43604268
131PDPK10.43236909
132MAP3K30.42919701
133ROCK20.41521818
134MAPK120.41432841
135PDGFRA0.40712756
136PIM20.40672760
137ERBB40.40324388
138PLK30.39528057
139PRKG20.39310131
140PAK30.38589840
141PRKCI0.38482885
142ROCK10.38321395
143PIK3CA0.37341398
144MUSK0.36134448
145MAPKAPK30.35313402
146AURKB0.33983803

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.40260771
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61229628
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90692300
4Collecting duct acid secretion_Homo sapiens_hsa049662.68432339
5Cardiac muscle contraction_Homo sapiens_hsa042602.64156758
6Oxidative phosphorylation_Homo sapiens_hsa001902.33237164
7Nicotine addiction_Homo sapiens_hsa050332.23698104
8DNA replication_Homo sapiens_hsa030302.11184163
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10854706
10Parkinsons disease_Homo sapiens_hsa050122.08176212
11Olfactory transduction_Homo sapiens_hsa047402.05581983
12* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.87318838
13* Carbon metabolism_Homo sapiens_hsa012001.85923062
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85860126
15Vibrio cholerae infection_Homo sapiens_hsa051101.85579061
16Dilated cardiomyopathy_Homo sapiens_hsa054141.84337348
17Fatty acid elongation_Homo sapiens_hsa000621.83843714
18Long-term potentiation_Homo sapiens_hsa047201.83305582
19Vitamin B6 metabolism_Homo sapiens_hsa007501.81237947
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79956042
21Circadian entrainment_Homo sapiens_hsa047131.78406014
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72130681
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70783303
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65879655
25Alzheimers disease_Homo sapiens_hsa050101.59371429
26GABAergic synapse_Homo sapiens_hsa047271.59108132
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.56699546
28Amphetamine addiction_Homo sapiens_hsa050311.55708424
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50024376
30Morphine addiction_Homo sapiens_hsa050321.48996271
31* Biosynthesis of amino acids_Homo sapiens_hsa012301.48444859
32Dopaminergic synapse_Homo sapiens_hsa047281.47486177
33Oxytocin signaling pathway_Homo sapiens_hsa049211.42806207
34Mismatch repair_Homo sapiens_hsa034301.40957169
35Arginine and proline metabolism_Homo sapiens_hsa003301.40220417
36Base excision repair_Homo sapiens_hsa034101.35209815
37Pyruvate metabolism_Homo sapiens_hsa006201.35080862
38Insulin secretion_Homo sapiens_hsa049111.33755325
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33026315
40Huntingtons disease_Homo sapiens_hsa050161.32957436
41Salivary secretion_Homo sapiens_hsa049701.31787308
42Calcium signaling pathway_Homo sapiens_hsa040201.30954123
43Gastric acid secretion_Homo sapiens_hsa049711.30399186
44Other glycan degradation_Homo sapiens_hsa005111.30184206
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26442873
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.20383873
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15610329
48Glucagon signaling pathway_Homo sapiens_hsa049221.14975675
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14929830
50Renin secretion_Homo sapiens_hsa049241.14409629
51* Fructose and mannose metabolism_Homo sapiens_hsa000511.12814278
52N-Glycan biosynthesis_Homo sapiens_hsa005101.11770080
53Glutamatergic synapse_Homo sapiens_hsa047241.11740794
54* HIF-1 signaling pathway_Homo sapiens_hsa040661.10744114
55Phototransduction_Homo sapiens_hsa047441.09253245
56Arginine biosynthesis_Homo sapiens_hsa002201.07881961
57Long-term depression_Homo sapiens_hsa047301.06523932
58Cholinergic synapse_Homo sapiens_hsa047251.03783210
59One carbon pool by folate_Homo sapiens_hsa006701.03316047
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00721074
61Proteasome_Homo sapiens_hsa030500.98552109
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98392717
63Glutathione metabolism_Homo sapiens_hsa004800.96888572
64Sulfur relay system_Homo sapiens_hsa041220.96884785
65Steroid biosynthesis_Homo sapiens_hsa001000.95041362
66Galactose metabolism_Homo sapiens_hsa000520.93729379
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93704086
68Gap junction_Homo sapiens_hsa045400.93019621
69Thyroid cancer_Homo sapiens_hsa052160.91660832
70Fatty acid metabolism_Homo sapiens_hsa012120.89534438
71GnRH signaling pathway_Homo sapiens_hsa049120.89447595
72Taste transduction_Homo sapiens_hsa047420.89267336
73RNA transport_Homo sapiens_hsa030130.87700370
74Oocyte meiosis_Homo sapiens_hsa041140.87414587
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85763226
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82711708
77Insulin signaling pathway_Homo sapiens_hsa049100.81767031
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81237837
79Serotonergic synapse_Homo sapiens_hsa047260.79846754
80Pyrimidine metabolism_Homo sapiens_hsa002400.78918667
81Spliceosome_Homo sapiens_hsa030400.78824049
82Bladder cancer_Homo sapiens_hsa052190.77056546
83Cell cycle_Homo sapiens_hsa041100.74933575
84Nucleotide excision repair_Homo sapiens_hsa034200.74666639
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.73864795
86Glioma_Homo sapiens_hsa052140.71935183
87Type II diabetes mellitus_Homo sapiens_hsa049300.71553168
88cAMP signaling pathway_Homo sapiens_hsa040240.71168607
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69075432
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67905158
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66058068
92Cocaine addiction_Homo sapiens_hsa050300.65938025
93Phagosome_Homo sapiens_hsa041450.64559206
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63728650
95Tight junction_Homo sapiens_hsa045300.61490984
96Prion diseases_Homo sapiens_hsa050200.61043308
97Estrogen signaling pathway_Homo sapiens_hsa049150.60908590
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58570359
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58464111
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.58149796
101Rheumatoid arthritis_Homo sapiens_hsa053230.58084101
102Melanogenesis_Homo sapiens_hsa049160.57364180
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.56996288
104mTOR signaling pathway_Homo sapiens_hsa041500.56628443
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55839845
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52173083
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.49494448
108ErbB signaling pathway_Homo sapiens_hsa040120.49310779
109mRNA surveillance pathway_Homo sapiens_hsa030150.49121809
110Shigellosis_Homo sapiens_hsa051310.48352072
111Purine metabolism_Homo sapiens_hsa002300.47845168
112Chronic myeloid leukemia_Homo sapiens_hsa052200.47468917
113Folate biosynthesis_Homo sapiens_hsa007900.45117192
114Non-small cell lung cancer_Homo sapiens_hsa052230.44161813
115Tyrosine metabolism_Homo sapiens_hsa003500.43341104
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42340430
117MAPK signaling pathway_Homo sapiens_hsa040100.41795120
118Circadian rhythm_Homo sapiens_hsa047100.41721873
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41230659
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41027706
121Lysosome_Homo sapiens_hsa041420.38899234
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38009730
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37811932
124* Pentose phosphate pathway_Homo sapiens_hsa000300.36947934
125Type I diabetes mellitus_Homo sapiens_hsa049400.36198533
126Adherens junction_Homo sapiens_hsa045200.35935692
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34433414
128* Metabolic pathways_Homo sapiens_hsa011000.34310312
129Acute myeloid leukemia_Homo sapiens_hsa052210.32831989
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32516353
131AMPK signaling pathway_Homo sapiens_hsa041520.32165240
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.32066732
133Thyroid hormone synthesis_Homo sapiens_hsa049180.30788312
134VEGF signaling pathway_Homo sapiens_hsa043700.30645203
135Viral carcinogenesis_Homo sapiens_hsa052030.30588972
136Endocytosis_Homo sapiens_hsa041440.30300270
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29865592
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28545623
139Propanoate metabolism_Homo sapiens_hsa006400.28542998
140Starch and sucrose metabolism_Homo sapiens_hsa005000.28443267
141Inositol phosphate metabolism_Homo sapiens_hsa005620.27732029
142Endometrial cancer_Homo sapiens_hsa052130.27455766
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26567239
144Proteoglycans in cancer_Homo sapiens_hsa052050.26556554
145RNA polymerase_Homo sapiens_hsa030200.26470354
146Lysine degradation_Homo sapiens_hsa003100.26451400
147Pancreatic cancer_Homo sapiens_hsa052120.26167342
148Renal cell carcinoma_Homo sapiens_hsa052110.26106177
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25082088
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24958857
151Phenylalanine metabolism_Homo sapiens_hsa003600.24411055
152Epstein-Barr virus infection_Homo sapiens_hsa051690.24393709

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »