ALDOAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.92971254
2proteasome assembly (GO:0043248)5.11064048
3rRNA modification (GO:0000154)4.75218242
4response to pheromone (GO:0019236)4.71850804
5rRNA methylation (GO:0031167)4.41870694
6regulation of cellular amino acid metabolic process (GO:0006521)4.38163353
7DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.24850459
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.24352609
9protein complex biogenesis (GO:0070271)4.22776254
10regulation of cytokine production involved in inflammatory response (GO:1900015)4.14336760
11respiratory chain complex IV assembly (GO:0008535)4.12466348
12signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.12043312
13signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.12043312
14signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.12043312
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.11003685
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.11003685
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.10761278
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.06700580
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.06700580
20protein neddylation (GO:0045116)4.01986847
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.00030837
22signal transduction involved in DNA damage checkpoint (GO:0072422)3.94696337
23signal transduction involved in DNA integrity checkpoint (GO:0072401)3.94696337
24mitochondrial respiratory chain complex assembly (GO:0033108)3.93342351
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92611398
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90468035
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.90468035
28NADH dehydrogenase complex assembly (GO:0010257)3.90468035
29peptidyl-histidine modification (GO:0018202)3.89518236
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.87868717
31maturation of 5.8S rRNA (GO:0000460)3.87116343
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85751824
33negative regulation of ligase activity (GO:0051352)3.85751824
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.81914255
35cullin deneddylation (GO:0010388)3.80148323
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77967545
37cytochrome complex assembly (GO:0017004)3.74133745
38mannosylation (GO:0097502)3.71329752
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71168401
40ATP synthesis coupled proton transport (GO:0015986)3.63315907
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63315907
42signal peptide processing (GO:0006465)3.59833393
43chaperone-mediated protein transport (GO:0072321)3.58342721
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57707317
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56847119
46protein deneddylation (GO:0000338)3.51852327
47ketone body metabolic process (GO:1902224)3.46661380
48pseudouridine synthesis (GO:0001522)3.43903707
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43656525
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42557019
51branched-chain amino acid catabolic process (GO:0009083)3.41139871
52water-soluble vitamin biosynthetic process (GO:0042364)3.39238385
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38264017
54positive regulation of ligase activity (GO:0051351)3.28591144
55protein targeting to mitochondrion (GO:0006626)3.27797015
56termination of RNA polymerase III transcription (GO:0006386)3.27255816
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.27255816
58protein maturation by protein folding (GO:0022417)3.27184794
59cellular ketone body metabolic process (GO:0046950)3.26570823
60cytidine deamination (GO:0009972)3.26162983
61cytidine metabolic process (GO:0046087)3.26162983
62cytidine catabolic process (GO:0006216)3.26162983
63respiratory electron transport chain (GO:0022904)3.25204192
64DNA double-strand break processing (GO:0000729)3.25196952
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22922972
66DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.22918180
67L-methionine biosynthetic process (GO:0071265)3.22308466
68amino acid salvage (GO:0043102)3.22308466
69L-methionine salvage (GO:0071267)3.22308466
70electron transport chain (GO:0022900)3.18660413
71regulation of translational termination (GO:0006449)3.18609723
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13471247
73sperm motility (GO:0030317)3.13018304
74regulation of cellular amine metabolic process (GO:0033238)3.08467844
75positive regulation of cell cycle arrest (GO:0071158)3.08027472
76DNA catabolic process, exonucleolytic (GO:0000738)3.07750328
77establishment of protein localization to mitochondrion (GO:0072655)3.00067516
78protein localization to mitochondrion (GO:0070585)2.97058657
79response to gravity (GO:0009629)2.95477290
80platelet dense granule organization (GO:0060155)2.95473852
81protein refolding (GO:0042026)2.94792706
82antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.89328665
83regulation of ubiquitin-protein transferase activity (GO:0051438)2.88318357
84protein polyglutamylation (GO:0018095)2.87644004
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85656098
86negative regulation of thymocyte apoptotic process (GO:0070244)2.84223087
87preassembly of GPI anchor in ER membrane (GO:0016254)2.80466354
88tRNA processing (GO:0008033)2.79882568
89regulation of ligase activity (GO:0051340)2.78975354
90regulation of immunoglobulin secretion (GO:0051023)2.73485431
91branched-chain amino acid metabolic process (GO:0009081)2.71361657
92establishment of viral latency (GO:0019043)2.69998492
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69963529
94isotype switching (GO:0045190)2.69963529
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69963529
96protein-cofactor linkage (GO:0018065)2.69794233
97regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.69138073
98fusion of sperm to egg plasma membrane (GO:0007342)2.68634278
99signal transduction in response to DNA damage (GO:0042770)2.65826981
100negative regulation of protein ubiquitination (GO:0031397)2.65339770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.21206989
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.74501009
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.91779575
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.89593396
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.81031851
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77310003
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52775784
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.15575024
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99506115
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91606981
11VDR_23849224_ChIP-Seq_CD4+_Human2.83922943
12VDR_22108803_ChIP-Seq_LS180_Human2.65185860
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.58906110
14ZNF274_21170338_ChIP-Seq_K562_Hela2.50619265
15FOXP3_21729870_ChIP-Seq_TREG_Human2.45257380
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40159094
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38796021
18ELK1_19687146_ChIP-ChIP_HELA_Human2.27530235
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20316253
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.17336856
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.01220372
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94767927
23GABP_19822575_ChIP-Seq_HepG2_Human1.89781199
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88151163
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74794539
26MYC_18940864_ChIP-ChIP_HL60_Human1.74263178
27DCP1A_22483619_ChIP-Seq_HELA_Human1.71650711
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70660697
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68830503
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68225292
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67406096
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64168794
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63506353
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60945233
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.60481726
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58438349
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56262174
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53639771
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.51679882
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51104803
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49857395
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42804189
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42359943
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41858500
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39331432
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37732843
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.35815232
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.35095307
49TTF2_22483619_ChIP-Seq_HELA_Human1.28065806
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24613455
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21880971
52TP53_22573176_ChIP-Seq_HFKS_Human1.20870847
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18958241
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18682408
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17941361
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17916522
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.17107694
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15811345
59KDM5A_27292631_Chip-Seq_BREAST_Human1.15481885
60FUS_26573619_Chip-Seq_HEK293_Human1.13797038
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12523757
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12502288
63AR_20517297_ChIP-Seq_VCAP_Human1.09817112
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08809622
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08016266
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05615608
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.03700543
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03700543
69GATA3_26560356_Chip-Seq_TH2_Human1.02914532
70NANOG_20526341_ChIP-Seq_ESCs_Human1.01369680
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01267498
72MYC_19829295_ChIP-Seq_ESCs_Human0.99357968
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99065977
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97067980
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96890003
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96286013
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96266848
78STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95079825
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94886271
80SOX2_19829295_ChIP-Seq_ESCs_Human0.93761933
81NANOG_19829295_ChIP-Seq_ESCs_Human0.93761933
82ERG_20517297_ChIP-Seq_VCAP_Human0.92836328
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91767875
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.91671648
85EWS_26573619_Chip-Seq_HEK293_Human0.91596294
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91265441
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.90925177
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90515525
89NCOR_22424771_ChIP-Seq_293T_Human0.89845451
90HTT_18923047_ChIP-ChIP_STHdh_Human0.89407802
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89102095
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88844694
93XRN2_22483619_ChIP-Seq_HELA_Human0.88067047
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87952957
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87462295
96TAF2_19829295_ChIP-Seq_ESCs_Human0.87248747
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86328176
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85725879
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84859604
100HOXB7_26014856_ChIP-Seq_BT474_Human0.84506987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.65477012
2MP0003806_abnormal_nucleotide_metabolis3.34080764
3MP0008875_abnormal_xenobiotic_pharmacok2.92572139
4MP0005410_abnormal_fertilization2.81523355
5MP0006036_abnormal_mitochondrial_physio2.68470111
6MP0008058_abnormal_DNA_repair2.54301561
7MP0003646_muscle_fatigue2.32936103
8MP0005671_abnormal_response_to2.30130875
9MP0001835_abnormal_antigen_presentation2.29938295
10MP0006035_abnormal_mitochondrial_morpho2.29370728
11MP0005075_abnormal_melanosome_morpholog2.28218499
12MP0001873_stomach_inflammation2.24309085
13MP0003718_maternal_effect2.23160887
14MP0000569_abnormal_digit_pigmentation2.21225321
15MP0000015_abnormal_ear_pigmentation2.12745150
16MP0009785_altered_susceptibility_to2.02518038
17MP0003786_premature_aging2.00455357
18MP0003186_abnormal_redox_activity1.97292692
19MP0002095_abnormal_skin_pigmentation1.96430393
20MP0005387_immune_system_phenotype1.95637245
21MP0001790_abnormal_immune_system1.95637245
22MP0002102_abnormal_ear_morphology1.88935568
23MP0008872_abnormal_physiological_respon1.88785967
24MP0008877_abnormal_DNA_methylation1.84385970
25MP0000749_muscle_degeneration1.82752587
26MP0005084_abnormal_gallbladder_morpholo1.69861612
27MP0003950_abnormal_plasma_membrane1.66815595
28MP0003195_calcinosis1.66752574
29MP0001661_extended_life_span1.65492915
30MP0005408_hypopigmentation1.63261353
31MP0005551_abnormal_eye_electrophysiolog1.62080465
32MP0002148_abnormal_hypersensitivity_rea1.60404428
33MP0002837_dystrophic_cardiac_calcinosis1.54872196
34MP0001905_abnormal_dopamine_level1.48783017
35MP0008775_abnormal_heart_ventricle1.44966498
36MP0004145_abnormal_muscle_electrophysio1.41403007
37MP0001764_abnormal_homeostasis1.38578814
38MP0002277_abnormal_respiratory_mucosa1.36267829
39MP0001529_abnormal_vocalization1.36183353
40MP0005253_abnormal_eye_physiology1.33791659
41MP0005083_abnormal_biliary_tract1.32711038
42MP0010094_abnormal_chromosome_stability1.31979510
43MP0003878_abnormal_ear_physiology1.31793132
44MP0005377_hearing/vestibular/ear_phenot1.31793132
45MP0002166_altered_tumor_susceptibility1.28047508
46MP0009333_abnormal_splenocyte_physiolog1.27870208
47MP0002006_tumorigenesis1.26381589
48MP0002876_abnormal_thyroid_physiology1.24399254
49MP0001800_abnormal_humoral_immune1.24071676
50MP0000685_abnormal_immune_system1.19903545
51MP0001929_abnormal_gametogenesis1.19105771
52MP0006054_spinal_hemorrhage1.17980376
53MP0005165_increased_susceptibility_to1.17642249
54MP0003693_abnormal_embryo_hatching1.16981120
55MP0002933_joint_inflammation1.11116734
56MP0006072_abnormal_retinal_apoptosis1.10582791
57MP0009046_muscle_twitch1.10232708
58MP0003436_decreased_susceptibility_to1.09267741
59MP0004147_increased_porphyrin_level1.08548192
60MP0002138_abnormal_hepatobiliary_system1.05569714
61MP0005000_abnormal_immune_tolerance1.02839558
62MP0000358_abnormal_cell_content/1.01135051
63MP0003698_abnormal_male_reproductive0.99823780
64MP0004142_abnormal_muscle_tone0.99452218
65MP0004957_abnormal_blastocyst_morpholog0.98535245
66MP0002723_abnormal_immune_serum0.97957147
67MP0005174_abnormal_tail_pigmentation0.95307535
68MP0001968_abnormal_touch/_nociception0.93633611
69MP0005636_abnormal_mineral_homeostasis0.92406872
70MP0005310_abnormal_salivary_gland0.91479821
71MP0003866_abnormal_defecation0.89965918
72MP0002282_abnormal_trachea_morphology0.87346672
73MP0010155_abnormal_intestine_physiology0.85988961
74MP0005171_absent_coat_pigmentation0.81412262
75MP0001853_heart_inflammation0.81370561
76MP0002452_abnormal_antigen_presenting0.80773397
77MP0005584_abnormal_enzyme/coenzyme_acti0.78677701
78MP0002736_abnormal_nociception_after0.78072553
79MP0009745_abnormal_behavioral_response0.78065996
80MP0002090_abnormal_vision0.77726663
81MP0002210_abnormal_sex_determination0.76944542
82MP0001501_abnormal_sleep_pattern0.76837652
83MP0002822_catalepsy0.76376295
84MP0003880_abnormal_central_pattern0.76290337
85MP0002272_abnormal_nervous_system0.76112116
86MP0005332_abnormal_amino_acid0.76031903
87MP0009697_abnormal_copulation0.75810101
88MP0008007_abnormal_cellular_replicative0.75453802
89MP0002693_abnormal_pancreas_physiology0.75448197
90MP0000371_diluted_coat_color0.75250476
91MP0000653_abnormal_sex_gland0.72870688
92MP0008469_abnormal_protein_level0.72831629
93MP0003011_delayed_dark_adaptation0.72728104
94MP0002420_abnormal_adaptive_immunity0.72201150
95MP0001819_abnormal_immune_cell0.72109635
96MP0000647_abnormal_sebaceous_gland0.71757970
97MP0005319_abnormal_enzyme/_coenzyme0.70837335
98MP0001324_abnormal_eye_pigmentation0.70799036
99MP0004484_altered_response_of0.70240654
100MP0008873_increased_physiological_sensi0.69910368

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.84229644
2Increased CSF lactate (HP:0002490)4.76862742
3Hepatocellular necrosis (HP:0001404)4.70429044
4Acute necrotizing encephalopathy (HP:0006965)4.69109952
5Renal Fanconi syndrome (HP:0001994)4.63336791
6Increased hepatocellular lipid droplets (HP:0006565)4.56984454
7Hepatic necrosis (HP:0002605)4.35704752
8Abnormal mitochondria in muscle tissue (HP:0008316)4.16231983
93-Methylglutaconic aciduria (HP:0003535)4.15178161
10Lipid accumulation in hepatocytes (HP:0006561)4.11532283
11Acute encephalopathy (HP:0006846)4.07594435
12Progressive macrocephaly (HP:0004481)3.99770371
13Increased serum lactate (HP:0002151)3.53639690
14Increased intramyocellular lipid droplets (HP:0012240)3.37898587
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35320024
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33398546
17Large for gestational age (HP:0001520)3.19509992
18Cerebral edema (HP:0002181)3.18290836
19Congenital stationary night blindness (HP:0007642)3.14904388
20Lactic acidosis (HP:0003128)3.14066497
21Exertional dyspnea (HP:0002875)3.11993733
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04758645
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04758645
24Increased serum pyruvate (HP:0003542)2.87055651
25Abnormality of glycolysis (HP:0004366)2.85732725
26Cerebral hypomyelination (HP:0006808)2.83064317
27Stomatitis (HP:0010280)2.72805959
28Respiratory difficulties (HP:0002880)2.71054513
29Increased muscle lipid content (HP:0009058)2.70696114
30Respiratory failure (HP:0002878)2.65452360
31Adrenal hypoplasia (HP:0000835)2.65369732
32Optic disc pallor (HP:0000543)2.63536302
33IgG deficiency (HP:0004315)2.63268483
34Exercise intolerance (HP:0003546)2.61724365
35Abnormality of renal resorption (HP:0011038)2.59778650
36Generalized aminoaciduria (HP:0002909)2.57418262
37Type I transferrin isoform profile (HP:0003642)2.57403475
38Methylmalonic aciduria (HP:0012120)2.51370574
39Lethargy (HP:0001254)2.50094623
40Abnormality of urine glucose concentration (HP:0011016)2.46452952
41Glycosuria (HP:0003076)2.46452952
42CNS demyelination (HP:0007305)2.43780835
43Congenital, generalized hypertrichosis (HP:0004540)2.33692328
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30587092
45Abnormal protein N-linked glycosylation (HP:0012347)2.30587092
46Abnormal protein glycosylation (HP:0012346)2.30587092
47Abnormal glycosylation (HP:0012345)2.30587092
48Cholecystitis (HP:0001082)2.30173438
49Abnormal gallbladder physiology (HP:0012438)2.30173438
50Emotional lability (HP:0000712)2.28500384
51Pancreatic cysts (HP:0001737)2.25367889
52Hypothermia (HP:0002045)2.25005343
53Nephronophthisis (HP:0000090)2.24680025
54Abnormality of midbrain morphology (HP:0002418)2.24558635
55Molar tooth sign on MRI (HP:0002419)2.24558635
56Elevated erythrocyte sedimentation rate (HP:0003565)2.24552387
57Pancreatic islet-cell hyperplasia (HP:0004510)2.22857935
58Progressive inability to walk (HP:0002505)2.19825212
59Hypoplasia of the fovea (HP:0007750)2.13250234
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.13250234
61Abnormality of the renal cortex (HP:0011035)2.10642356
62Leukodystrophy (HP:0002415)2.10288661
63Abnormal spermatogenesis (HP:0008669)2.09867278
64Abnormality of alanine metabolism (HP:0010916)2.09190104
65Hyperalaninemia (HP:0003348)2.09190104
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09190104
67Aplastic anemia (HP:0001915)2.08854187
68Methylmalonic acidemia (HP:0002912)2.07786737
69Insulin-resistant diabetes mellitus (HP:0000831)2.06488724
70CNS hypomyelination (HP:0003429)2.05932425
71Reduced subcutaneous adipose tissue (HP:0003758)2.04138428
72Abnormality of the renal medulla (HP:0100957)2.01794299
73Aplasia/hypoplasia of the uterus (HP:0008684)2.01607706
74Inability to walk (HP:0002540)1.98828248
75Type 2 muscle fiber atrophy (HP:0003554)1.97681537
76Abnormality of macular pigmentation (HP:0008002)1.95739346
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93042476
78Oral leukoplakia (HP:0002745)1.93014672
79Renal cortical cysts (HP:0000803)1.90734576
80Severe visual impairment (HP:0001141)1.90637562
81Abnormality of T cell physiology (HP:0011840)1.89492972
82IgA deficiency (HP:0002720)1.87783341
83Attenuation of retinal blood vessels (HP:0007843)1.87375097
84Progressive microcephaly (HP:0000253)1.85994487
85Abnormality of the pons (HP:0007361)1.83998928
86Blindness (HP:0000618)1.80038203
87Abnormality of the fovea (HP:0000493)1.76023048
88Muscle fiber atrophy (HP:0100295)1.75333358
89Polydipsia (HP:0001959)1.73871980
90Abnormal drinking behavior (HP:0030082)1.73871980
91Hyperphosphaturia (HP:0003109)1.73393605
92Polyuria (HP:0000103)1.72093439
93Median cleft lip (HP:0000161)1.72072624
94X-linked dominant inheritance (HP:0001423)1.70883718
95Opisthotonus (HP:0002179)1.70861197
96Hypoplasia of the uterus (HP:0000013)1.70631545
97Abnormality of methionine metabolism (HP:0010901)1.70520214
98Pancytopenia (HP:0001876)1.69353127
99Sparse eyelashes (HP:0000653)1.68354313
100Amniotic constriction ring (HP:0009775)1.67944545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.81346117
2BCKDK3.18984866
3TXK2.99490569
4EIF2AK12.95886115
5TSSK62.66827671
6MST42.54785562
7NEK12.45242671
8EIF2AK32.38763495
9NUAK12.29196414
10MAP3K122.25148030
11VRK12.15668228
12PHKG22.14626128
13PHKG12.14626128
14TLK12.10492660
15PDK22.05741957
16TESK11.99833755
17WNK41.97775762
18MAP4K21.91823514
19BUB11.88412762
20ZAK1.77152786
21NME21.71640178
22MAPKAPK51.61648407
23LIMK11.61354791
24PLK31.60738725
25FRK1.60317712
26TAOK31.54237745
27DAPK11.50643146
28STK161.50175863
29SRPK11.49048370
30TRIM281.45424033
31PLK21.27520711
32CSNK1G31.25227254
33MAPKAPK31.22118998
34STK391.21371192
35GRK51.19551582
36ADRBK21.18663530
37ARAF1.16611320
38INSRR1.16048347
39PINK11.15795370
40MAP2K61.14621703
41CCNB11.14456820
42STK38L1.10972629
43OXSR11.06326763
44CSNK1G21.06080358
45GRK11.03591766
46CSNK1G11.01427238
47CSNK1A1L1.01217464
48EIF2AK20.96081707
49MYLK0.95461227
50TIE10.92906155
51BMPR1B0.88023589
52TAF10.87441326
53PTK2B0.83404724
54PLK40.82810662
55IKBKB0.81590141
56TESK20.75872392
57PBK0.75643057
58ACVR1B0.71485604
59NME10.71298508
60OBSCN0.65177935
61PIM20.62934703
62WNK30.61673381
63CAMKK20.56646933
64KDR0.51797884
65ILK0.48266940
66WEE10.45409718
67ATR0.45013774
68DAPK20.43548218
69PRKD30.42971170
70DAPK30.42716453
71RPS6KA50.42601149
72ABL20.42528385
73TEC0.42456600
74LMTK20.40609852
75PRKG20.40478111
76ADRBK10.40029265
77PLK10.38588794
78CSF1R0.37618810
79MAP2K70.36504013
80ERBB30.36406871
81PAK40.34111394
82TTK0.33784124
83CSNK2A10.33328546
84JAK30.33036371
85PRKCQ0.31011846
86MAP3K130.30914321
87ITK0.30416048
88PIK3CG0.29574727
89PRKCE0.29562886
90PRKCG0.28314259
91CSNK2A20.28059318
92MAPK130.27881894
93PRKCI0.26915720
94CDK70.26166882
95SYK0.24830996
96ERBB40.24766621
97FLT30.23960226
98STK380.23867068
99MOS0.22689152
100PRKG10.22655255

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.60974415
2Oxidative phosphorylation_Homo sapiens_hsa001903.36307482
3Parkinsons disease_Homo sapiens_hsa050122.85323892
4Protein export_Homo sapiens_hsa030602.81563571
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57141012
6RNA polymerase_Homo sapiens_hsa030202.33189045
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31789120
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08646987
9Homologous recombination_Homo sapiens_hsa034402.00221486
10Caffeine metabolism_Homo sapiens_hsa002321.97849263
11Huntingtons disease_Homo sapiens_hsa050161.93721539
12Alzheimers disease_Homo sapiens_hsa050101.87206470
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79223631
14Propanoate metabolism_Homo sapiens_hsa006401.77908249
15Allograft rejection_Homo sapiens_hsa053301.75750320
16Autoimmune thyroid disease_Homo sapiens_hsa053201.75083841
17One carbon pool by folate_Homo sapiens_hsa006701.56196287
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55172538
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51040944
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50910403
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49511961
22Fatty acid elongation_Homo sapiens_hsa000621.49246458
23Ribosome_Homo sapiens_hsa030101.42757958
24Basal transcription factors_Homo sapiens_hsa030221.42667367
25Non-homologous end-joining_Homo sapiens_hsa034501.40111353
26Mismatch repair_Homo sapiens_hsa034301.39926667
27Asthma_Homo sapiens_hsa053101.37709222
28RNA degradation_Homo sapiens_hsa030181.33839236
29Primary immunodeficiency_Homo sapiens_hsa053401.31801244
30Nucleotide excision repair_Homo sapiens_hsa034201.30898623
31Pyrimidine metabolism_Homo sapiens_hsa002401.30075043
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.27110134
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25630130
34DNA replication_Homo sapiens_hsa030301.25379117
35Spliceosome_Homo sapiens_hsa030401.23987069
36Fanconi anemia pathway_Homo sapiens_hsa034601.21683397
37Folate biosynthesis_Homo sapiens_hsa007901.18510444
38Antigen processing and presentation_Homo sapiens_hsa046121.18194122
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17580133
40RNA transport_Homo sapiens_hsa030131.12944532
41Type I diabetes mellitus_Homo sapiens_hsa049401.10783711
42Base excision repair_Homo sapiens_hsa034101.08758526
43Purine metabolism_Homo sapiens_hsa002301.08344271
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06242082
45Butanoate metabolism_Homo sapiens_hsa006501.05937023
46Phototransduction_Homo sapiens_hsa047441.03245895
47Regulation of autophagy_Homo sapiens_hsa041401.02367822
48Pyruvate metabolism_Homo sapiens_hsa006201.00375696
49Linoleic acid metabolism_Homo sapiens_hsa005910.99773579
50Glutathione metabolism_Homo sapiens_hsa004800.98775045
51Rheumatoid arthritis_Homo sapiens_hsa053230.95431820
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94729750
53Cardiac muscle contraction_Homo sapiens_hsa042600.94626332
54Carbon metabolism_Homo sapiens_hsa012000.92868971
55Graft-versus-host disease_Homo sapiens_hsa053320.92774483
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.90734518
57Peroxisome_Homo sapiens_hsa041460.89378907
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.87520559
59Nitrogen metabolism_Homo sapiens_hsa009100.84254259
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83362013
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82866908
62Pentose phosphate pathway_Homo sapiens_hsa000300.82277019
63Metabolic pathways_Homo sapiens_hsa011000.81611724
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80884319
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78620531
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75970698
67Collecting duct acid secretion_Homo sapiens_hsa049660.75337243
68Sulfur relay system_Homo sapiens_hsa041220.74640387
69Biosynthesis of amino acids_Homo sapiens_hsa012300.74171486
70Steroid biosynthesis_Homo sapiens_hsa001000.67036227
71Arachidonic acid metabolism_Homo sapiens_hsa005900.66632172
72Ether lipid metabolism_Homo sapiens_hsa005650.64298869
73N-Glycan biosynthesis_Homo sapiens_hsa005100.62836843
74Tryptophan metabolism_Homo sapiens_hsa003800.62387125
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61688771
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58605442
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.57089076
78Chemical carcinogenesis_Homo sapiens_hsa052040.56879827
79Sulfur metabolism_Homo sapiens_hsa009200.54363334
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.51177917
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48687278
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48013960
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47772339
84Epstein-Barr virus infection_Homo sapiens_hsa051690.47226129
85Salivary secretion_Homo sapiens_hsa049700.42100569
86Fatty acid metabolism_Homo sapiens_hsa012120.38696171
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37811806
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37420893
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36824763
90Fat digestion and absorption_Homo sapiens_hsa049750.36335662
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34846246
92Measles_Homo sapiens_hsa051620.34840230
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34567081
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34143322
95Legionellosis_Homo sapiens_hsa051340.34025517
96Fructose and mannose metabolism_Homo sapiens_hsa000510.33234248
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26843266
98Vitamin B6 metabolism_Homo sapiens_hsa007500.26654902
99Arginine and proline metabolism_Homo sapiens_hsa003300.26502890
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.26481771

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