ALDOAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)9.48957638
2cytidine deamination (GO:0009972)9.48957638
3cytidine metabolic process (GO:0046087)9.48957638
4DNA deamination (GO:0045006)8.94082308
5pyrimidine ribonucleoside catabolic process (GO:0046133)8.23827516
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.60621272
7negative regulation by host of viral transcription (GO:0043922)4.93580801
8eosinophil chemotaxis (GO:0048245)4.45695730
9regulation of cellular amino acid metabolic process (GO:0006521)4.09978252
10response to gravity (GO:0009629)4.06935879
11cullin deneddylation (GO:0010388)4.06321414
12eosinophil migration (GO:0072677)4.00779087
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98695740
14pyrimidine nucleoside catabolic process (GO:0046135)3.92219513
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.91601168
16protein deneddylation (GO:0000338)3.89937251
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88889149
18cellular response to interleukin-15 (GO:0071350)3.81894733
19proteasome assembly (GO:0043248)3.78975249
20signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.77870930
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.77870930
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76297984
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.74795828
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.74795828
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.74795828
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67652945
27regulation of lymphocyte chemotaxis (GO:1901623)3.65540663
28platelet dense granule organization (GO:0060155)3.62645838
29positive regulation of calcium-mediated signaling (GO:0050850)3.58120646
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.57480095
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57480095
32protein neddylation (GO:0045116)3.56868748
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56372831
34negative regulation of ligase activity (GO:0051352)3.56258153
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56258153
36regulation of chronic inflammatory response (GO:0002676)3.54133054
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.52250333
38negative regulation of T cell apoptotic process (GO:0070233)3.44736766
39positive regulation of interleukin-8 secretion (GO:2000484)3.43814786
40protein complex biogenesis (GO:0070271)3.42928178
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42319984
42respiratory electron transport chain (GO:0022904)3.41514815
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38502944
44ATP synthesis coupled proton transport (GO:0015986)3.36644566
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36644566
46electron transport chain (GO:0022900)3.36059086
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.33999455
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33057995
49macrophage chemotaxis (GO:0048246)3.28278374
50DNA demethylation (GO:0080111)3.27465675
51pyrimidine ribonucleoside metabolic process (GO:0046131)3.25333142
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24950545
53positive regulation of cell cycle arrest (GO:0071158)3.20744798
54mitochondrial respiratory chain complex assembly (GO:0033108)3.19678755
55positive regulation of ligase activity (GO:0051351)3.09830069
56regulation of activation of Janus kinase activity (GO:0010533)3.08708559
57actin nucleation (GO:0045010)3.02799132
58positive regulation of lymphocyte migration (GO:2000403)3.02766088
59negative regulation of viral transcription (GO:0032897)2.99381878
60negative regulation of viral genome replication (GO:0045071)2.99314987
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.98160128
62NADH dehydrogenase complex assembly (GO:0010257)2.98160128
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98160128
64positive regulation of defense response to virus by host (GO:0002230)2.94329367
65DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94106927
66regulation of cellular amine metabolic process (GO:0033238)2.91952093
67positive regulation of T cell chemotaxis (GO:0010820)2.90780501
68regulation of T cell chemotaxis (GO:0010819)2.90780501
69termination of RNA polymerase III transcription (GO:0006386)2.88601325
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.88601325
71sequestering of actin monomers (GO:0042989)2.86523700
72protein maturation by protein folding (GO:0022417)2.86057075
73regulation of regulatory T cell differentiation (GO:0045589)2.83093694
74antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.82424530
75regulation of interleukin-8 secretion (GO:2000482)2.81830921
76modulation by host of symbiont transcription (GO:0052472)2.78724421
77modulation by host of viral transcription (GO:0043921)2.78724421
78DNA dealkylation (GO:0035510)2.78372191
79regulation of calcium-mediated signaling (GO:0050848)2.74681574
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.74191075
81response to interleukin-15 (GO:0070672)2.72103217
82regulation of skeletal muscle contraction (GO:0014819)2.71567680
83positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.69969187
84regulation of ubiquitin-protein transferase activity (GO:0051438)2.69639171
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69592509
86T cell receptor signaling pathway (GO:0050852)2.67576892
87regulation of alpha-beta T cell proliferation (GO:0046640)2.66348301
88positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65466362
89response to interferon-beta (GO:0035456)2.65048772
90monocyte chemotaxis (GO:0002548)2.64997198
91regulation of cell cycle arrest (GO:0071156)2.64458077
92regulation of isotype switching to IgG isotypes (GO:0048302)2.63669476
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.63365369
94lymphocyte costimulation (GO:0031294)2.62971289
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62660675
96modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.62442367
97negative regulation of lymphocyte apoptotic process (GO:0070229)2.62418641
98muscle filament sliding (GO:0030049)2.61950779
99actin-myosin filament sliding (GO:0033275)2.61950779
100pyrimidine-containing compound catabolic process (GO:0072529)2.61701403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.57985825
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.89763062
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11788843
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.93939677
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.61508371
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17124286
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.13692024
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97413327
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96665344
10VDR_22108803_ChIP-Seq_LS180_Human2.90388216
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67925345
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59793952
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56787144
14VDR_23849224_ChIP-Seq_CD4+_Human2.51375855
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38008469
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.26708988
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15799304
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.15606857
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05775595
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04354662
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.02307107
22FOXP3_21729870_ChIP-Seq_TREG_Human1.98996333
23HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82264052
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76603271
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73223726
26ELK1_19687146_ChIP-ChIP_HELA_Human1.72833253
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71729163
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.68484553
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68480551
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66379156
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60192538
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53993266
33ZNF274_21170338_ChIP-Seq_K562_Hela1.50683729
34DCP1A_22483619_ChIP-Seq_HELA_Human1.48442913
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46366015
36MYB_26560356_Chip-Seq_TH2_Human1.44293345
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43465950
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37473308
39PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36425115
40MYC_18940864_ChIP-ChIP_HL60_Human1.33957361
41HTT_18923047_ChIP-ChIP_STHdh_Human1.33640581
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33216773
43TP53_22573176_ChIP-Seq_HFKS_Human1.29647743
44GATA3_26560356_Chip-Seq_TH2_Human1.29332741
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29173285
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28566014
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25919752
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17247775
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.15462436
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14319702
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13638357
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12914627
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12049624
54TAF15_26573619_Chip-Seq_HEK293_Human1.10230423
55AR_20517297_ChIP-Seq_VCAP_Human1.09694294
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08710183
57IRF1_19129219_ChIP-ChIP_H3396_Human1.08137682
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07596711
59GABP_19822575_ChIP-Seq_HepG2_Human1.06434330
60ERG_20517297_ChIP-Seq_VCAP_Human1.05459455
61GATA3_27048872_Chip-Seq_THYMUS_Human1.03861243
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03663972
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03098203
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02965043
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02356365
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01731191
67IGF1R_20145208_ChIP-Seq_DFB_Human1.01648767
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01579511
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00617857
70TAF2_19829295_ChIP-Seq_ESCs_Human0.99397537
71YY1_21170310_ChIP-Seq_MESCs_Mouse0.98801086
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98664225
73CIITA_25753668_ChIP-Seq_RAJI_Human0.97174289
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97045138
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.96565036
76THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94785418
77SOX2_19829295_ChIP-Seq_ESCs_Human0.94656093
78NANOG_19829295_ChIP-Seq_ESCs_Human0.94656093
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94648957
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90368949
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89033514
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88733984
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.88408761
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87929110
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87558603
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.87558603
87NANOG_20526341_ChIP-Seq_ESCs_Human0.87378401
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85702556
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85439119
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85419153
91MYC_19829295_ChIP-Seq_ESCs_Human0.85408097
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83641075
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83491232
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82153391
95MYB_26560356_Chip-Seq_TH1_Human0.81716561
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81133633
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80735185
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79602211
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79200783
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78795956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.73105873
2MP0000372_irregular_coat_pigmentation3.62183452
3MP0000569_abnormal_digit_pigmentation3.03642851
4MP0001835_abnormal_antigen_presentation2.77279809
5MP0004145_abnormal_muscle_electrophysio2.77204516
6MP0009333_abnormal_splenocyte_physiolog2.67174712
7MP0003786_premature_aging2.46859076
8MP0009785_altered_susceptibility_to2.41759199
9MP0003011_delayed_dark_adaptation2.21080936
10MP0003763_abnormal_thymus_physiology2.16518351
11MP0003806_abnormal_nucleotide_metabolis2.11535672
12MP0002166_altered_tumor_susceptibility2.06578821
13MP0004147_increased_porphyrin_level2.03940380
14MP0006082_CNS_inflammation1.99080941
15MP0002277_abnormal_respiratory_mucosa1.97789603
16MP0002148_abnormal_hypersensitivity_rea1.97087769
17MP0005000_abnormal_immune_tolerance1.93938481
18MP0001800_abnormal_humoral_immune1.85978005
19MP0001529_abnormal_vocalization1.81704388
20MP0002006_tumorigenesis1.81613350
21MP0002638_abnormal_pupillary_reflex1.75584887
22MP0006036_abnormal_mitochondrial_physio1.74891979
23MP0002723_abnormal_immune_serum1.72295184
24MP0001984_abnormal_olfaction1.71497864
25MP0001790_abnormal_immune_system1.66103808
26MP0005387_immune_system_phenotype1.66103808
27MP0006072_abnormal_retinal_apoptosis1.63129129
28MP0000749_muscle_degeneration1.61791810
29MP0002420_abnormal_adaptive_immunity1.61192782
30MP0001873_stomach_inflammation1.59605011
31MP0006054_spinal_hemorrhage1.57112644
32MP0003866_abnormal_defecation1.55246890
33MP0001661_extended_life_span1.55077345
34MP0001819_abnormal_immune_cell1.54931088
35MP0004036_abnormal_muscle_relaxation1.54507250
36MP0002102_abnormal_ear_morphology1.48981041
37MP0003646_muscle_fatigue1.47403440
38MP0006035_abnormal_mitochondrial_morpho1.45932211
39MP0003195_calcinosis1.44440435
40MP0005253_abnormal_eye_physiology1.41637719
41MP0002163_abnormal_gland_morphology1.41146721
42MP0001905_abnormal_dopamine_level1.35338097
43MP0000747_muscle_weakness1.34055857
44MP0005551_abnormal_eye_electrophysiolog1.32565458
45MP0003878_abnormal_ear_physiology1.31776869
46MP0005377_hearing/vestibular/ear_phenot1.31776869
47MP0002095_abnormal_skin_pigmentation1.29204438
48MP0005084_abnormal_gallbladder_morpholo1.29080030
49MP0008872_abnormal_physiological_respon1.28919763
50MP0002736_abnormal_nociception_after1.28702930
51MP0002398_abnormal_bone_marrow1.27614338
52MP0000716_abnormal_immune_system1.26382077
53MP0006276_abnormal_autonomic_nervous1.23273970
54MP0000685_abnormal_immune_system1.22951762
55MP0002452_abnormal_antigen_presenting1.19681077
56MP0005645_abnormal_hypothalamus_physiol1.18052270
57MP0005025_abnormal_response_to1.17933225
58MP0001968_abnormal_touch/_nociception1.17842938
59MP0002269_muscular_atrophy1.14212867
60MP0002876_abnormal_thyroid_physiology1.13724332
61MP0002106_abnormal_muscle_physiology1.09211702
62MP0005620_abnormal_muscle_contractility1.09009801
63MP0002138_abnormal_hepatobiliary_system1.08194075
64MP0008058_abnormal_DNA_repair1.05631503
65MP0001188_hyperpigmentation1.05331659
66MP0000703_abnormal_thymus_morphology1.03800326
67MP0008789_abnormal_olfactory_epithelium1.01972687
68MP0002429_abnormal_blood_cell1.01716329
69MP0000689_abnormal_spleen_morphology1.01397323
70MP0002877_abnormal_melanocyte_morpholog1.00653888
71MP0002722_abnormal_immune_system0.98970237
72MP0010155_abnormal_intestine_physiology0.98189627
73MP0009765_abnormal_xenobiotic_induced0.91865912
74MP0002837_dystrophic_cardiac_calcinosis0.91086609
75MP0003880_abnormal_central_pattern0.90982630
76MP0005410_abnormal_fertilization0.90269809
77MP0008875_abnormal_xenobiotic_pharmacok0.88465228
78MP0003448_altered_tumor_morphology0.86808086
79MP0002405_respiratory_system_inflammati0.84980088
80MP0005310_abnormal_salivary_gland0.82796368
81MP0009745_abnormal_behavioral_response0.82016240
82MP0001845_abnormal_inflammatory_respons0.81513359
83MP0003567_abnormal_fetal_cardiomyocyte0.81429474
84MP0005167_abnormal_blood-brain_barrier0.81202538
85MP0005584_abnormal_enzyme/coenzyme_acti0.79441329
86MP0003436_decreased_susceptibility_to0.78802982
87MP0001764_abnormal_homeostasis0.77866517
88MP0004043_abnormal_pH_regulation0.77548621
89MP0005636_abnormal_mineral_homeostasis0.76816994
90MP0003136_yellow_coat_color0.76650954
91MP0009763_increased_sensitivity_to0.76460440
92MP0000759_abnormal_skeletal_muscle0.76366057
93MP0008469_abnormal_protein_level0.75758236
94MP0000358_abnormal_cell_content/0.75238623
95MP0008995_early_reproductive_senescence0.74387946
96MP0001542_abnormal_bone_strength0.74131824
97MP0005369_muscle_phenotype0.73607439
98MP0003137_abnormal_impulse_conducting0.73056189
99MP0004084_abnormal_cardiac_muscle0.72151050
100MP0002933_joint_inflammation0.71305739

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.68650589
2Aplastic anemia (HP:0001915)4.62488064
3Hepatocellular necrosis (HP:0001404)4.46685823
4Acute necrotizing encephalopathy (HP:0006965)4.45674502
5Abnormality of T cell number (HP:0011839)4.45620756
6Mitochondrial inheritance (HP:0001427)4.42779055
7Abnormal mitochondria in muscle tissue (HP:0008316)4.15896603
8Palpebral edema (HP:0100540)4.04214785
9Hepatic necrosis (HP:0002605)3.98344887
10Increased CSF lactate (HP:0002490)3.90580264
113-Methylglutaconic aciduria (HP:0003535)3.88483008
12Acute encephalopathy (HP:0006846)3.66116769
13Progressive macrocephaly (HP:0004481)3.63749599
14Hypoproteinemia (HP:0003075)3.63104123
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60482098
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60482098
17Type I transferrin isoform profile (HP:0003642)3.25246760
18IgG deficiency (HP:0004315)3.23480964
19Abnormality of T cells (HP:0002843)3.18656045
20Myoglobinuria (HP:0002913)3.07642015
21Chronic diarrhea (HP:0002028)3.00465515
22Cerebral edema (HP:0002181)2.97268143
23Increased intramyocellular lipid droplets (HP:0012240)2.94823052
24Severe combined immunodeficiency (HP:0004430)2.91970842
25Increased serum lactate (HP:0002151)2.86016978
26Hypothermia (HP:0002045)2.75512189
27Increased hepatocellular lipid droplets (HP:0006565)2.73658172
28Optic disc pallor (HP:0000543)2.65137317
29Lipid accumulation in hepatocytes (HP:0006561)2.63717233
30Periorbital edema (HP:0100539)2.62822138
31Lactic acidosis (HP:0003128)2.60814967
32Exercise intolerance (HP:0003546)2.60781027
33Rhabdomyolysis (HP:0003201)2.60395571
34Oral leukoplakia (HP:0002745)2.59584772
35Facial edema (HP:0000282)2.59250765
36Palpitations (HP:0001962)2.55638692
37Congenital, generalized hypertrichosis (HP:0004540)2.51272384
38Autoimmune hemolytic anemia (HP:0001890)2.47864706
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46445153
40Abnormal protein N-linked glycosylation (HP:0012347)2.46445153
41Abnormal protein glycosylation (HP:0012346)2.46445153
42Abnormal glycosylation (HP:0012345)2.46445153
43Increased muscle lipid content (HP:0009058)2.44711569
44Respiratory failure (HP:0002878)2.40184450
45Nemaline bodies (HP:0003798)2.38223487
46Hypoalbuminemia (HP:0003073)2.38081475
47Abnormal albumin level (HP:0012116)2.38081475
48Abnormality of eosinophils (HP:0001879)2.36639716
49Renal Fanconi syndrome (HP:0001994)2.36455401
50Thyroiditis (HP:0100646)2.35909999
51Increased IgM level (HP:0003496)2.33505749
52Reduced subcutaneous adipose tissue (HP:0003758)2.32636000
53Reduced antithrombin III activity (HP:0001976)2.30377309
54Renal cortical cysts (HP:0000803)2.27472125
55Pancreatic cysts (HP:0001737)2.26952582
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26353137
57Joint swelling (HP:0001386)2.24281324
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22600459
59Elevated erythrocyte sedimentation rate (HP:0003565)2.18755039
60Short tibia (HP:0005736)2.16309980
61Increased serum pyruvate (HP:0003542)2.15838365
62Molar tooth sign on MRI (HP:0002419)2.14831572
63Abnormality of midbrain morphology (HP:0002418)2.14831572
64Abnormality of the prostate (HP:0008775)2.13391961
65Combined immunodeficiency (HP:0005387)2.11643454
66Distal arthrogryposis (HP:0005684)2.10980479
67Eosinophilia (HP:0001880)2.07387646
68Cerebral palsy (HP:0100021)2.06633039
69Muscle fiber inclusion bodies (HP:0100299)2.05397399
70Exercise-induced muscle cramps (HP:0003710)2.04923281
71Congenital stationary night blindness (HP:0007642)2.04635751
72Exertional dyspnea (HP:0002875)1.99044270
73Absent phalangeal crease (HP:0006109)1.98562387
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98555017
75Abnormality of glycolysis (HP:0004366)1.96330069
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94618057
77Emotional lability (HP:0000712)1.94357836
78Generalized aminoaciduria (HP:0002909)1.93841078
79Aplasia/hypoplasia of the uterus (HP:0008684)1.93007261
80Stomatitis (HP:0010280)1.91843227
81Abnormality of T cell physiology (HP:0011840)1.89390175
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.88602857
83Dicarboxylic aciduria (HP:0003215)1.88397162
84Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88397162
85CNS demyelination (HP:0007305)1.86306962
86Leukodystrophy (HP:0002415)1.85721664
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.85649574
88Hypoplasia of the thymus (HP:0000778)1.84593389
89Pancytopenia (HP:0001876)1.83928197
90True hermaphroditism (HP:0010459)1.80900908
91Recurrent cutaneous fungal infections (HP:0011370)1.79571321
92Chronic mucocutaneous candidiasis (HP:0002728)1.79571321
93Abnormal finger flexion creases (HP:0006143)1.78790306
94Entropion (HP:0000621)1.78550073
95Methylmalonic aciduria (HP:0012120)1.78211044
96Pancreatic fibrosis (HP:0100732)1.77418201
97Lethargy (HP:0001254)1.76774007
98Attenuation of retinal blood vessels (HP:0007843)1.76681757
99Delayed CNS myelination (HP:0002188)1.76086134
100Abnormal gallbladder physiology (HP:0012438)1.74878772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.67457255
2KDR3.32991251
3TESK23.32609726
4BCKDK2.88578766
5VRK22.78365630
6MST42.24469918
7NUAK12.13314535
8TIE12.12637163
9MAP3K122.10053386
10MAP4K22.03909000
11PHKG11.98597724
12PHKG21.98597724
13EIF2AK31.97644348
14TESK11.94188433
15BUB11.92453796
16ADRBK21.90251838
17LIMK11.84835734
18MAP4K11.84656877
19TLK11.76689098
20OBSCN1.71048338
21ZAK1.53155835
22ITK1.52959509
23VRK11.50426419
24DAPK11.49768266
25CSNK1G31.44177356
26GRK11.40992043
27TAOK31.39390525
28DAPK21.38775508
29WNK41.38251587
30BMPR1B1.31067637
31BCR1.29798222
32CSNK1A1L1.28615539
33CSNK1G11.25889853
34CSNK1G21.25006300
35MAPKAPK31.16771414
36WNK31.13130594
37SCYL21.12912970
38PIK3CG1.12787498
39MYLK1.09460239
40FES1.07981665
41PIK3CA1.04466617
42SRPK11.04152556
43EIF2AK11.01190781
44PRKCQ0.98967899
45OXSR10.96127984
46NEK10.93997249
47MAPK130.91227379
48SYK0.87708486
49TSSK60.86770488
50TRIM280.86131183
51MAP2K70.81762002
52IKBKB0.80170447
53FRK0.79714467
54AURKA0.78932768
55CDK80.75471774
56GRK50.74346766
57LCK0.72558777
58DYRK20.71408713
59MATK0.70139095
60CAMKK20.69713584
61NME10.68956851
62INSRR0.68535954
63JAK30.66675064
64DAPK30.63483098
65PIM20.62633900
66PLK20.62396099
67PDK20.61863031
68NTRK10.59625205
69LMTK20.58259146
70ILK0.58013774
71STK160.57636485
72PINK10.56708045
73CCNB10.55193032
74MUSK0.54878864
75FGFR10.54877762
76IKBKE0.54827422
77PRKD30.52932208
78TEC0.52620061
79ARAF0.52056175
80LYN0.51736255
81CAMK2G0.45242665
82CSK0.43327686
83RPS6KA50.43229393
84MAP3K110.42274567
85BMPR20.42049245
86EIF2AK20.40053519
87ACVR1B0.39956956
88PLK30.39062415
89IGF1R0.38891417
90STK390.38046665
91BLK0.36235200
92GRK70.36038728
93ADRBK10.35466573
94ATR0.33225266
95GRK60.32324084
96PAK10.32195703
97CSF1R0.32128522
98KIT0.31477291
99MARK30.31424201
100CAMK2A0.31277736

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.54554090
2Oxidative phosphorylation_Homo sapiens_hsa001903.51658631
3Primary immunodeficiency_Homo sapiens_hsa053403.10195006
4Parkinsons disease_Homo sapiens_hsa050123.05722966
5Autoimmune thyroid disease_Homo sapiens_hsa053202.99198373
6Graft-versus-host disease_Homo sapiens_hsa053322.96964677
7Allograft rejection_Homo sapiens_hsa053302.94464129
8Antigen processing and presentation_Homo sapiens_hsa046122.67841541
9Protein export_Homo sapiens_hsa030602.66727646
10Type I diabetes mellitus_Homo sapiens_hsa049402.28434929
11Asthma_Homo sapiens_hsa053102.17566728
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17198028
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12444367
14Alzheimers disease_Homo sapiens_hsa050102.08902937
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06680858
16Rheumatoid arthritis_Homo sapiens_hsa053231.98603016
17RNA polymerase_Homo sapiens_hsa030201.94835106
18Huntingtons disease_Homo sapiens_hsa050161.82054615
19Regulation of autophagy_Homo sapiens_hsa041401.78591550
20Cardiac muscle contraction_Homo sapiens_hsa042601.66282530
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63816541
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.60929782
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54982395
24Hematopoietic cell lineage_Homo sapiens_hsa046401.47821686
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46599070
26Propanoate metabolism_Homo sapiens_hsa006401.32159695
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28741944
28T cell receptor signaling pathway_Homo sapiens_hsa046601.19459544
29Nitrogen metabolism_Homo sapiens_hsa009101.19292883
30Systemic lupus erythematosus_Homo sapiens_hsa053221.15807333
31Viral myocarditis_Homo sapiens_hsa054161.15517096
32Fatty acid elongation_Homo sapiens_hsa000621.12351955
33Ribosome_Homo sapiens_hsa030101.09481844
34Phototransduction_Homo sapiens_hsa047441.08600989
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01378846
36Nucleotide excision repair_Homo sapiens_hsa034201.00521700
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93427638
38Collecting duct acid secretion_Homo sapiens_hsa049660.88958740
39RNA degradation_Homo sapiens_hsa030180.88511211
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86489568
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84355883
42Pyrimidine metabolism_Homo sapiens_hsa002400.81304763
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80763130
44Purine metabolism_Homo sapiens_hsa002300.80025301
45Homologous recombination_Homo sapiens_hsa034400.79460052
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78191168
47Steroid biosynthesis_Homo sapiens_hsa001000.77064957
48One carbon pool by folate_Homo sapiens_hsa006700.75844192
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75573017
50Spliceosome_Homo sapiens_hsa030400.74934630
51Salmonella infection_Homo sapiens_hsa051320.74796250
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.74495981
53Measles_Homo sapiens_hsa051620.72235628
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70385547
55Linoleic acid metabolism_Homo sapiens_hsa005910.67358520
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64127272
57Carbon metabolism_Homo sapiens_hsa012000.63803220
58Non-homologous end-joining_Homo sapiens_hsa034500.63698505
59Butanoate metabolism_Homo sapiens_hsa006500.62841515
60Shigellosis_Homo sapiens_hsa051310.61289952
61Basal transcription factors_Homo sapiens_hsa030220.60216369
62Tryptophan metabolism_Homo sapiens_hsa003800.59582765
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58048402
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57645172
65Mismatch repair_Homo sapiens_hsa034300.55795818
66Pyruvate metabolism_Homo sapiens_hsa006200.55121380
67Peroxisome_Homo sapiens_hsa041460.53792674
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51793149
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50149949
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49968185
71N-Glycan biosynthesis_Homo sapiens_hsa005100.48505093
72DNA replication_Homo sapiens_hsa030300.47394314
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45750305
74Metabolic pathways_Homo sapiens_hsa011000.45272503
75Epstein-Barr virus infection_Homo sapiens_hsa051690.44876032
76Biosynthesis of amino acids_Homo sapiens_hsa012300.42203880
77Sulfur metabolism_Homo sapiens_hsa009200.40408346
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38822713
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35532799
80Fanconi anemia pathway_Homo sapiens_hsa034600.34757944
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34105703
82Herpes simplex infection_Homo sapiens_hsa051680.33982576
83Vibrio cholerae infection_Homo sapiens_hsa051100.31561252
84Chemical carcinogenesis_Homo sapiens_hsa052040.30433530
85Folate biosynthesis_Homo sapiens_hsa007900.30356948
86Olfactory transduction_Homo sapiens_hsa047400.29462683
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.27813102
88Staphylococcus aureus infection_Homo sapiens_hsa051500.27194556
89Circadian rhythm_Homo sapiens_hsa047100.25972031
90Pentose phosphate pathway_Homo sapiens_hsa000300.25253117
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24737932
92Retinol metabolism_Homo sapiens_hsa008300.24355465
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.23898851
94Alcoholism_Homo sapiens_hsa050340.21686438
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19951525
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18572368
97RNA transport_Homo sapiens_hsa030130.17678209
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15714572
99Oocyte meiosis_Homo sapiens_hsa041140.15666911
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14257233

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