Rank | Gene Set | Z-score |
---|---|---|
1 | cytidine catabolic process (GO:0006216) | 9.48957638 |
2 | cytidine deamination (GO:0009972) | 9.48957638 |
3 | cytidine metabolic process (GO:0046087) | 9.48957638 |
4 | DNA deamination (GO:0045006) | 8.94082308 |
5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 8.23827516 |
6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.60621272 |
7 | negative regulation by host of viral transcription (GO:0043922) | 4.93580801 |
8 | eosinophil chemotaxis (GO:0048245) | 4.45695730 |
9 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.09978252 |
10 | response to gravity (GO:0009629) | 4.06935879 |
11 | cullin deneddylation (GO:0010388) | 4.06321414 |
12 | eosinophil migration (GO:0072677) | 4.00779087 |
13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.98695740 |
14 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.92219513 |
15 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.91601168 |
16 | protein deneddylation (GO:0000338) | 3.89937251 |
17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.88889149 |
18 | cellular response to interleukin-15 (GO:0071350) | 3.81894733 |
19 | proteasome assembly (GO:0043248) | 3.78975249 |
20 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.77870930 |
21 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.77870930 |
22 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.76297984 |
23 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.74795828 |
24 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.74795828 |
25 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.74795828 |
26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.67652945 |
27 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.65540663 |
28 | platelet dense granule organization (GO:0060155) | 3.62645838 |
29 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.58120646 |
30 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.57480095 |
31 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.57480095 |
32 | protein neddylation (GO:0045116) | 3.56868748 |
33 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.56372831 |
34 | negative regulation of ligase activity (GO:0051352) | 3.56258153 |
35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.56258153 |
36 | regulation of chronic inflammatory response (GO:0002676) | 3.54133054 |
37 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.52250333 |
38 | negative regulation of T cell apoptotic process (GO:0070233) | 3.44736766 |
39 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.43814786 |
40 | protein complex biogenesis (GO:0070271) | 3.42928178 |
41 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.42319984 |
42 | respiratory electron transport chain (GO:0022904) | 3.41514815 |
43 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.38502944 |
44 | ATP synthesis coupled proton transport (GO:0015986) | 3.36644566 |
45 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.36644566 |
46 | electron transport chain (GO:0022900) | 3.36059086 |
47 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.33999455 |
48 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.33057995 |
49 | macrophage chemotaxis (GO:0048246) | 3.28278374 |
50 | DNA demethylation (GO:0080111) | 3.27465675 |
51 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 3.25333142 |
52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.24950545 |
53 | positive regulation of cell cycle arrest (GO:0071158) | 3.20744798 |
54 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.19678755 |
55 | positive regulation of ligase activity (GO:0051351) | 3.09830069 |
56 | regulation of activation of Janus kinase activity (GO:0010533) | 3.08708559 |
57 | actin nucleation (GO:0045010) | 3.02799132 |
58 | positive regulation of lymphocyte migration (GO:2000403) | 3.02766088 |
59 | negative regulation of viral transcription (GO:0032897) | 2.99381878 |
60 | negative regulation of viral genome replication (GO:0045071) | 2.99314987 |
61 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.98160128 |
62 | NADH dehydrogenase complex assembly (GO:0010257) | 2.98160128 |
63 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.98160128 |
64 | positive regulation of defense response to virus by host (GO:0002230) | 2.94329367 |
65 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.94106927 |
66 | regulation of cellular amine metabolic process (GO:0033238) | 2.91952093 |
67 | positive regulation of T cell chemotaxis (GO:0010820) | 2.90780501 |
68 | regulation of T cell chemotaxis (GO:0010819) | 2.90780501 |
69 | termination of RNA polymerase III transcription (GO:0006386) | 2.88601325 |
70 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.88601325 |
71 | sequestering of actin monomers (GO:0042989) | 2.86523700 |
72 | protein maturation by protein folding (GO:0022417) | 2.86057075 |
73 | regulation of regulatory T cell differentiation (GO:0045589) | 2.83093694 |
74 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.82424530 |
75 | regulation of interleukin-8 secretion (GO:2000482) | 2.81830921 |
76 | modulation by host of symbiont transcription (GO:0052472) | 2.78724421 |
77 | modulation by host of viral transcription (GO:0043921) | 2.78724421 |
78 | DNA dealkylation (GO:0035510) | 2.78372191 |
79 | regulation of calcium-mediated signaling (GO:0050848) | 2.74681574 |
80 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.74191075 |
81 | response to interleukin-15 (GO:0070672) | 2.72103217 |
82 | regulation of skeletal muscle contraction (GO:0014819) | 2.71567680 |
83 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 2.69969187 |
84 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.69639171 |
85 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.69592509 |
86 | T cell receptor signaling pathway (GO:0050852) | 2.67576892 |
87 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.66348301 |
88 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.65466362 |
89 | response to interferon-beta (GO:0035456) | 2.65048772 |
90 | monocyte chemotaxis (GO:0002548) | 2.64997198 |
91 | regulation of cell cycle arrest (GO:0071156) | 2.64458077 |
92 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.63669476 |
93 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.63365369 |
94 | lymphocyte costimulation (GO:0031294) | 2.62971289 |
95 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.62660675 |
96 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 2.62442367 |
97 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.62418641 |
98 | muscle filament sliding (GO:0030049) | 2.61950779 |
99 | actin-myosin filament sliding (GO:0033275) | 2.61950779 |
100 | pyrimidine-containing compound catabolic process (GO:0072529) | 2.61701403 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 8.57985825 |
2 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.89763062 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.11788843 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.93939677 |
5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.61508371 |
6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.17124286 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.13692024 |
8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.97413327 |
9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.96665344 |
10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.90388216 |
11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.67925345 |
12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59793952 |
13 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.56787144 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.51375855 |
15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.38008469 |
16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.26708988 |
17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.15799304 |
18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.15606857 |
19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.05775595 |
20 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.04354662 |
21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.02307107 |
22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.98996333 |
23 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.82264052 |
24 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.76603271 |
25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.73223726 |
26 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.72833253 |
27 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.71729163 |
28 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.68484553 |
29 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.68480551 |
30 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.66379156 |
31 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.60192538 |
32 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.53993266 |
33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.50683729 |
34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.48442913 |
35 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46366015 |
36 | MYB_26560356_Chip-Seq_TH2_Human | 1.44293345 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.43465950 |
38 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.37473308 |
39 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.36425115 |
40 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.33957361 |
41 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.33640581 |
42 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.33216773 |
43 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.29647743 |
44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.29332741 |
45 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.29173285 |
46 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28566014 |
47 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.25919752 |
48 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.17247775 |
49 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.15462436 |
50 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.14319702 |
51 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.13638357 |
52 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.12914627 |
53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.12049624 |
54 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10230423 |
55 | AR_20517297_ChIP-Seq_VCAP_Human | 1.09694294 |
56 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.08710183 |
57 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.08137682 |
58 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.07596711 |
59 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.06434330 |
60 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.05459455 |
61 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.03861243 |
62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.03663972 |
63 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.03098203 |
64 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02965043 |
65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02356365 |
66 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.01731191 |
67 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01648767 |
68 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.01579511 |
69 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.00617857 |
70 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.99397537 |
71 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.98801086 |
72 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.98664225 |
73 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.97174289 |
74 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.97045138 |
75 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96565036 |
76 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.94785418 |
77 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.94656093 |
78 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.94656093 |
79 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.94648957 |
80 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90368949 |
81 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.89033514 |
82 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.88733984 |
83 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.88408761 |
84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87929110 |
85 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.87558603 |
86 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.87558603 |
87 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.87378401 |
88 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85702556 |
89 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85439119 |
90 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.85419153 |
91 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.85408097 |
92 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.83641075 |
93 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.83491232 |
94 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.82153391 |
95 | MYB_26560356_Chip-Seq_TH1_Human | 0.81716561 |
96 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.81133633 |
97 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.80735185 |
98 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.79602211 |
99 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.79200783 |
100 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.78795956 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005671_abnormal_response_to | 4.73105873 |
2 | MP0000372_irregular_coat_pigmentation | 3.62183452 |
3 | MP0000569_abnormal_digit_pigmentation | 3.03642851 |
4 | MP0001835_abnormal_antigen_presentation | 2.77279809 |
5 | MP0004145_abnormal_muscle_electrophysio | 2.77204516 |
6 | MP0009333_abnormal_splenocyte_physiolog | 2.67174712 |
7 | MP0003786_premature_aging | 2.46859076 |
8 | MP0009785_altered_susceptibility_to | 2.41759199 |
9 | MP0003011_delayed_dark_adaptation | 2.21080936 |
10 | MP0003763_abnormal_thymus_physiology | 2.16518351 |
11 | MP0003806_abnormal_nucleotide_metabolis | 2.11535672 |
12 | MP0002166_altered_tumor_susceptibility | 2.06578821 |
13 | MP0004147_increased_porphyrin_level | 2.03940380 |
14 | MP0006082_CNS_inflammation | 1.99080941 |
15 | MP0002277_abnormal_respiratory_mucosa | 1.97789603 |
16 | MP0002148_abnormal_hypersensitivity_rea | 1.97087769 |
17 | MP0005000_abnormal_immune_tolerance | 1.93938481 |
18 | MP0001800_abnormal_humoral_immune | 1.85978005 |
19 | MP0001529_abnormal_vocalization | 1.81704388 |
20 | MP0002006_tumorigenesis | 1.81613350 |
21 | MP0002638_abnormal_pupillary_reflex | 1.75584887 |
22 | MP0006036_abnormal_mitochondrial_physio | 1.74891979 |
23 | MP0002723_abnormal_immune_serum | 1.72295184 |
24 | MP0001984_abnormal_olfaction | 1.71497864 |
25 | MP0001790_abnormal_immune_system | 1.66103808 |
26 | MP0005387_immune_system_phenotype | 1.66103808 |
27 | MP0006072_abnormal_retinal_apoptosis | 1.63129129 |
28 | MP0000749_muscle_degeneration | 1.61791810 |
29 | MP0002420_abnormal_adaptive_immunity | 1.61192782 |
30 | MP0001873_stomach_inflammation | 1.59605011 |
31 | MP0006054_spinal_hemorrhage | 1.57112644 |
32 | MP0003866_abnormal_defecation | 1.55246890 |
33 | MP0001661_extended_life_span | 1.55077345 |
34 | MP0001819_abnormal_immune_cell | 1.54931088 |
35 | MP0004036_abnormal_muscle_relaxation | 1.54507250 |
36 | MP0002102_abnormal_ear_morphology | 1.48981041 |
37 | MP0003646_muscle_fatigue | 1.47403440 |
38 | MP0006035_abnormal_mitochondrial_morpho | 1.45932211 |
39 | MP0003195_calcinosis | 1.44440435 |
40 | MP0005253_abnormal_eye_physiology | 1.41637719 |
41 | MP0002163_abnormal_gland_morphology | 1.41146721 |
42 | MP0001905_abnormal_dopamine_level | 1.35338097 |
43 | MP0000747_muscle_weakness | 1.34055857 |
44 | MP0005551_abnormal_eye_electrophysiolog | 1.32565458 |
45 | MP0003878_abnormal_ear_physiology | 1.31776869 |
46 | MP0005377_hearing/vestibular/ear_phenot | 1.31776869 |
47 | MP0002095_abnormal_skin_pigmentation | 1.29204438 |
48 | MP0005084_abnormal_gallbladder_morpholo | 1.29080030 |
49 | MP0008872_abnormal_physiological_respon | 1.28919763 |
50 | MP0002736_abnormal_nociception_after | 1.28702930 |
51 | MP0002398_abnormal_bone_marrow | 1.27614338 |
52 | MP0000716_abnormal_immune_system | 1.26382077 |
53 | MP0006276_abnormal_autonomic_nervous | 1.23273970 |
54 | MP0000685_abnormal_immune_system | 1.22951762 |
55 | MP0002452_abnormal_antigen_presenting | 1.19681077 |
56 | MP0005645_abnormal_hypothalamus_physiol | 1.18052270 |
57 | MP0005025_abnormal_response_to | 1.17933225 |
58 | MP0001968_abnormal_touch/_nociception | 1.17842938 |
59 | MP0002269_muscular_atrophy | 1.14212867 |
60 | MP0002876_abnormal_thyroid_physiology | 1.13724332 |
61 | MP0002106_abnormal_muscle_physiology | 1.09211702 |
62 | MP0005620_abnormal_muscle_contractility | 1.09009801 |
63 | MP0002138_abnormal_hepatobiliary_system | 1.08194075 |
64 | MP0008058_abnormal_DNA_repair | 1.05631503 |
65 | MP0001188_hyperpigmentation | 1.05331659 |
66 | MP0000703_abnormal_thymus_morphology | 1.03800326 |
67 | MP0008789_abnormal_olfactory_epithelium | 1.01972687 |
68 | MP0002429_abnormal_blood_cell | 1.01716329 |
69 | MP0000689_abnormal_spleen_morphology | 1.01397323 |
70 | MP0002877_abnormal_melanocyte_morpholog | 1.00653888 |
71 | MP0002722_abnormal_immune_system | 0.98970237 |
72 | MP0010155_abnormal_intestine_physiology | 0.98189627 |
73 | MP0009765_abnormal_xenobiotic_induced | 0.91865912 |
74 | MP0002837_dystrophic_cardiac_calcinosis | 0.91086609 |
75 | MP0003880_abnormal_central_pattern | 0.90982630 |
76 | MP0005410_abnormal_fertilization | 0.90269809 |
77 | MP0008875_abnormal_xenobiotic_pharmacok | 0.88465228 |
78 | MP0003448_altered_tumor_morphology | 0.86808086 |
79 | MP0002405_respiratory_system_inflammati | 0.84980088 |
80 | MP0005310_abnormal_salivary_gland | 0.82796368 |
81 | MP0009745_abnormal_behavioral_response | 0.82016240 |
82 | MP0001845_abnormal_inflammatory_respons | 0.81513359 |
83 | MP0003567_abnormal_fetal_cardiomyocyte | 0.81429474 |
84 | MP0005167_abnormal_blood-brain_barrier | 0.81202538 |
85 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.79441329 |
86 | MP0003436_decreased_susceptibility_to | 0.78802982 |
87 | MP0001764_abnormal_homeostasis | 0.77866517 |
88 | MP0004043_abnormal_pH_regulation | 0.77548621 |
89 | MP0005636_abnormal_mineral_homeostasis | 0.76816994 |
90 | MP0003136_yellow_coat_color | 0.76650954 |
91 | MP0009763_increased_sensitivity_to | 0.76460440 |
92 | MP0000759_abnormal_skeletal_muscle | 0.76366057 |
93 | MP0008469_abnormal_protein_level | 0.75758236 |
94 | MP0000358_abnormal_cell_content/ | 0.75238623 |
95 | MP0008995_early_reproductive_senescence | 0.74387946 |
96 | MP0001542_abnormal_bone_strength | 0.74131824 |
97 | MP0005369_muscle_phenotype | 0.73607439 |
98 | MP0003137_abnormal_impulse_conducting | 0.73056189 |
99 | MP0004084_abnormal_cardiac_muscle | 0.72151050 |
100 | MP0002933_joint_inflammation | 0.71305739 |
Rank | Gene Set | Z-score |
---|---|---|
1 | T lymphocytopenia (HP:0005403) | 4.68650589 |
2 | Aplastic anemia (HP:0001915) | 4.62488064 |
3 | Hepatocellular necrosis (HP:0001404) | 4.46685823 |
4 | Acute necrotizing encephalopathy (HP:0006965) | 4.45674502 |
5 | Abnormality of T cell number (HP:0011839) | 4.45620756 |
6 | Mitochondrial inheritance (HP:0001427) | 4.42779055 |
7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.15896603 |
8 | Palpebral edema (HP:0100540) | 4.04214785 |
9 | Hepatic necrosis (HP:0002605) | 3.98344887 |
10 | Increased CSF lactate (HP:0002490) | 3.90580264 |
11 | 3-Methylglutaconic aciduria (HP:0003535) | 3.88483008 |
12 | Acute encephalopathy (HP:0006846) | 3.66116769 |
13 | Progressive macrocephaly (HP:0004481) | 3.63749599 |
14 | Hypoproteinemia (HP:0003075) | 3.63104123 |
15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60482098 |
16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60482098 |
17 | Type I transferrin isoform profile (HP:0003642) | 3.25246760 |
18 | IgG deficiency (HP:0004315) | 3.23480964 |
19 | Abnormality of T cells (HP:0002843) | 3.18656045 |
20 | Myoglobinuria (HP:0002913) | 3.07642015 |
21 | Chronic diarrhea (HP:0002028) | 3.00465515 |
22 | Cerebral edema (HP:0002181) | 2.97268143 |
23 | Increased intramyocellular lipid droplets (HP:0012240) | 2.94823052 |
24 | Severe combined immunodeficiency (HP:0004430) | 2.91970842 |
25 | Increased serum lactate (HP:0002151) | 2.86016978 |
26 | Hypothermia (HP:0002045) | 2.75512189 |
27 | Increased hepatocellular lipid droplets (HP:0006565) | 2.73658172 |
28 | Optic disc pallor (HP:0000543) | 2.65137317 |
29 | Lipid accumulation in hepatocytes (HP:0006561) | 2.63717233 |
30 | Periorbital edema (HP:0100539) | 2.62822138 |
31 | Lactic acidosis (HP:0003128) | 2.60814967 |
32 | Exercise intolerance (HP:0003546) | 2.60781027 |
33 | Rhabdomyolysis (HP:0003201) | 2.60395571 |
34 | Oral leukoplakia (HP:0002745) | 2.59584772 |
35 | Facial edema (HP:0000282) | 2.59250765 |
36 | Palpitations (HP:0001962) | 2.55638692 |
37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.51272384 |
38 | Autoimmune hemolytic anemia (HP:0001890) | 2.47864706 |
39 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.46445153 |
40 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.46445153 |
41 | Abnormal protein glycosylation (HP:0012346) | 2.46445153 |
42 | Abnormal glycosylation (HP:0012345) | 2.46445153 |
43 | Increased muscle lipid content (HP:0009058) | 2.44711569 |
44 | Respiratory failure (HP:0002878) | 2.40184450 |
45 | Nemaline bodies (HP:0003798) | 2.38223487 |
46 | Hypoalbuminemia (HP:0003073) | 2.38081475 |
47 | Abnormal albumin level (HP:0012116) | 2.38081475 |
48 | Abnormality of eosinophils (HP:0001879) | 2.36639716 |
49 | Renal Fanconi syndrome (HP:0001994) | 2.36455401 |
50 | Thyroiditis (HP:0100646) | 2.35909999 |
51 | Increased IgM level (HP:0003496) | 2.33505749 |
52 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.32636000 |
53 | Reduced antithrombin III activity (HP:0001976) | 2.30377309 |
54 | Renal cortical cysts (HP:0000803) | 2.27472125 |
55 | Pancreatic cysts (HP:0001737) | 2.26952582 |
56 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.26353137 |
57 | Joint swelling (HP:0001386) | 2.24281324 |
58 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.22600459 |
59 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.18755039 |
60 | Short tibia (HP:0005736) | 2.16309980 |
61 | Increased serum pyruvate (HP:0003542) | 2.15838365 |
62 | Molar tooth sign on MRI (HP:0002419) | 2.14831572 |
63 | Abnormality of midbrain morphology (HP:0002418) | 2.14831572 |
64 | Abnormality of the prostate (HP:0008775) | 2.13391961 |
65 | Combined immunodeficiency (HP:0005387) | 2.11643454 |
66 | Distal arthrogryposis (HP:0005684) | 2.10980479 |
67 | Eosinophilia (HP:0001880) | 2.07387646 |
68 | Cerebral palsy (HP:0100021) | 2.06633039 |
69 | Muscle fiber inclusion bodies (HP:0100299) | 2.05397399 |
70 | Exercise-induced muscle cramps (HP:0003710) | 2.04923281 |
71 | Congenital stationary night blindness (HP:0007642) | 2.04635751 |
72 | Exertional dyspnea (HP:0002875) | 1.99044270 |
73 | Absent phalangeal crease (HP:0006109) | 1.98562387 |
74 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.98555017 |
75 | Abnormality of glycolysis (HP:0004366) | 1.96330069 |
76 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.94618057 |
77 | Emotional lability (HP:0000712) | 1.94357836 |
78 | Generalized aminoaciduria (HP:0002909) | 1.93841078 |
79 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93007261 |
80 | Stomatitis (HP:0010280) | 1.91843227 |
81 | Abnormality of T cell physiology (HP:0011840) | 1.89390175 |
82 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.88602857 |
83 | Dicarboxylic aciduria (HP:0003215) | 1.88397162 |
84 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.88397162 |
85 | CNS demyelination (HP:0007305) | 1.86306962 |
86 | Leukodystrophy (HP:0002415) | 1.85721664 |
87 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.85649574 |
88 | Hypoplasia of the thymus (HP:0000778) | 1.84593389 |
89 | Pancytopenia (HP:0001876) | 1.83928197 |
90 | True hermaphroditism (HP:0010459) | 1.80900908 |
91 | Recurrent cutaneous fungal infections (HP:0011370) | 1.79571321 |
92 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.79571321 |
93 | Abnormal finger flexion creases (HP:0006143) | 1.78790306 |
94 | Entropion (HP:0000621) | 1.78550073 |
95 | Methylmalonic aciduria (HP:0012120) | 1.78211044 |
96 | Pancreatic fibrosis (HP:0100732) | 1.77418201 |
97 | Lethargy (HP:0001254) | 1.76774007 |
98 | Attenuation of retinal blood vessels (HP:0007843) | 1.76681757 |
99 | Delayed CNS myelination (HP:0002188) | 1.76086134 |
100 | Abnormal gallbladder physiology (HP:0012438) | 1.74878772 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TXK | 5.67457255 |
2 | KDR | 3.32991251 |
3 | TESK2 | 3.32609726 |
4 | BCKDK | 2.88578766 |
5 | VRK2 | 2.78365630 |
6 | MST4 | 2.24469918 |
7 | NUAK1 | 2.13314535 |
8 | TIE1 | 2.12637163 |
9 | MAP3K12 | 2.10053386 |
10 | MAP4K2 | 2.03909000 |
11 | PHKG1 | 1.98597724 |
12 | PHKG2 | 1.98597724 |
13 | EIF2AK3 | 1.97644348 |
14 | TESK1 | 1.94188433 |
15 | BUB1 | 1.92453796 |
16 | ADRBK2 | 1.90251838 |
17 | LIMK1 | 1.84835734 |
18 | MAP4K1 | 1.84656877 |
19 | TLK1 | 1.76689098 |
20 | OBSCN | 1.71048338 |
21 | ZAK | 1.53155835 |
22 | ITK | 1.52959509 |
23 | VRK1 | 1.50426419 |
24 | DAPK1 | 1.49768266 |
25 | CSNK1G3 | 1.44177356 |
26 | GRK1 | 1.40992043 |
27 | TAOK3 | 1.39390525 |
28 | DAPK2 | 1.38775508 |
29 | WNK4 | 1.38251587 |
30 | BMPR1B | 1.31067637 |
31 | BCR | 1.29798222 |
32 | CSNK1A1L | 1.28615539 |
33 | CSNK1G1 | 1.25889853 |
34 | CSNK1G2 | 1.25006300 |
35 | MAPKAPK3 | 1.16771414 |
36 | WNK3 | 1.13130594 |
37 | SCYL2 | 1.12912970 |
38 | PIK3CG | 1.12787498 |
39 | MYLK | 1.09460239 |
40 | FES | 1.07981665 |
41 | PIK3CA | 1.04466617 |
42 | SRPK1 | 1.04152556 |
43 | EIF2AK1 | 1.01190781 |
44 | PRKCQ | 0.98967899 |
45 | OXSR1 | 0.96127984 |
46 | NEK1 | 0.93997249 |
47 | MAPK13 | 0.91227379 |
48 | SYK | 0.87708486 |
49 | TSSK6 | 0.86770488 |
50 | TRIM28 | 0.86131183 |
51 | MAP2K7 | 0.81762002 |
52 | IKBKB | 0.80170447 |
53 | FRK | 0.79714467 |
54 | AURKA | 0.78932768 |
55 | CDK8 | 0.75471774 |
56 | GRK5 | 0.74346766 |
57 | LCK | 0.72558777 |
58 | DYRK2 | 0.71408713 |
59 | MATK | 0.70139095 |
60 | CAMKK2 | 0.69713584 |
61 | NME1 | 0.68956851 |
62 | INSRR | 0.68535954 |
63 | JAK3 | 0.66675064 |
64 | DAPK3 | 0.63483098 |
65 | PIM2 | 0.62633900 |
66 | PLK2 | 0.62396099 |
67 | PDK2 | 0.61863031 |
68 | NTRK1 | 0.59625205 |
69 | LMTK2 | 0.58259146 |
70 | ILK | 0.58013774 |
71 | STK16 | 0.57636485 |
72 | PINK1 | 0.56708045 |
73 | CCNB1 | 0.55193032 |
74 | MUSK | 0.54878864 |
75 | FGFR1 | 0.54877762 |
76 | IKBKE | 0.54827422 |
77 | PRKD3 | 0.52932208 |
78 | TEC | 0.52620061 |
79 | ARAF | 0.52056175 |
80 | LYN | 0.51736255 |
81 | CAMK2G | 0.45242665 |
82 | CSK | 0.43327686 |
83 | RPS6KA5 | 0.43229393 |
84 | MAP3K11 | 0.42274567 |
85 | BMPR2 | 0.42049245 |
86 | EIF2AK2 | 0.40053519 |
87 | ACVR1B | 0.39956956 |
88 | PLK3 | 0.39062415 |
89 | IGF1R | 0.38891417 |
90 | STK39 | 0.38046665 |
91 | BLK | 0.36235200 |
92 | GRK7 | 0.36038728 |
93 | ADRBK1 | 0.35466573 |
94 | ATR | 0.33225266 |
95 | GRK6 | 0.32324084 |
96 | PAK1 | 0.32195703 |
97 | CSF1R | 0.32128522 |
98 | KIT | 0.31477291 |
99 | MARK3 | 0.31424201 |
100 | CAMK2A | 0.31277736 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 5.54554090 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.51658631 |
3 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.10195006 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.05722966 |
5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.99198373 |
6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.96964677 |
7 | Allograft rejection_Homo sapiens_hsa05330 | 2.94464129 |
8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.67841541 |
9 | Protein export_Homo sapiens_hsa03060 | 2.66727646 |
10 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.28434929 |
11 | Asthma_Homo sapiens_hsa05310 | 2.17566728 |
12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.17198028 |
13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.12444367 |
14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.08902937 |
15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.06680858 |
16 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.98603016 |
17 | RNA polymerase_Homo sapiens_hsa03020 | 1.94835106 |
18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.82054615 |
19 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.78591550 |
20 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.66282530 |
21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.63816541 |
22 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.60929782 |
23 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.54982395 |
24 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.47821686 |
25 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.46599070 |
26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.32159695 |
27 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.28741944 |
28 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.19459544 |
29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.19292883 |
30 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.15807333 |
31 | Viral myocarditis_Homo sapiens_hsa05416 | 1.15517096 |
32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.12351955 |
33 | Ribosome_Homo sapiens_hsa03010 | 1.09481844 |
34 | Phototransduction_Homo sapiens_hsa04744 | 1.08600989 |
35 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.01378846 |
36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.00521700 |
37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.93427638 |
38 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.88958740 |
39 | RNA degradation_Homo sapiens_hsa03018 | 0.88511211 |
40 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.86489568 |
41 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84355883 |
42 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.81304763 |
43 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.80763130 |
44 | Purine metabolism_Homo sapiens_hsa00230 | 0.80025301 |
45 | Homologous recombination_Homo sapiens_hsa03440 | 0.79460052 |
46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.78191168 |
47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.77064957 |
48 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.75844192 |
49 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.75573017 |
50 | Spliceosome_Homo sapiens_hsa03040 | 0.74934630 |
51 | Salmonella infection_Homo sapiens_hsa05132 | 0.74796250 |
52 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.74495981 |
53 | Measles_Homo sapiens_hsa05162 | 0.72235628 |
54 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.70385547 |
55 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67358520 |
56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64127272 |
57 | Carbon metabolism_Homo sapiens_hsa01200 | 0.63803220 |
58 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.63698505 |
59 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.62841515 |
60 | Shigellosis_Homo sapiens_hsa05131 | 0.61289952 |
61 | Basal transcription factors_Homo sapiens_hsa03022 | 0.60216369 |
62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.59582765 |
63 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.58048402 |
64 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.57645172 |
65 | Mismatch repair_Homo sapiens_hsa03430 | 0.55795818 |
66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.55121380 |
67 | Peroxisome_Homo sapiens_hsa04146 | 0.53792674 |
68 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.51793149 |
69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.50149949 |
70 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.49968185 |
71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.48505093 |
72 | DNA replication_Homo sapiens_hsa03030 | 0.47394314 |
73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.45750305 |
74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45272503 |
75 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.44876032 |
76 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.42203880 |
77 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.40408346 |
78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.38822713 |
79 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35532799 |
80 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.34757944 |
81 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.34105703 |
82 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.33982576 |
83 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.31561252 |
84 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.30433530 |
85 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.30356948 |
86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.29462683 |
87 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.27813102 |
88 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.27194556 |
89 | Circadian rhythm_Homo sapiens_hsa04710 | 0.25972031 |
90 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.25253117 |
91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24737932 |
92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24355465 |
93 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.23898851 |
94 | Alcoholism_Homo sapiens_hsa05034 | 0.21686438 |
95 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.19951525 |
96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.18572368 |
97 | RNA transport_Homo sapiens_hsa03013 | 0.17678209 |
98 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.15714572 |
99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.15666911 |
100 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.14257233 |