ALDOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.66571148
2epoxygenase P450 pathway (GO:0019373)8.53358657
3L-phenylalanine catabolic process (GO:0006559)7.31422270
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.31422270
5L-phenylalanine metabolic process (GO:0006558)7.08927401
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08927401
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.06138960
8aromatic amino acid family catabolic process (GO:0009074)6.66291695
9fat-soluble vitamin biosynthetic process (GO:0042362)6.65029352
10glyoxylate metabolic process (GO:0046487)6.08322089
11tryptophan catabolic process (GO:0006569)6.05771077
12indole-containing compound catabolic process (GO:0042436)6.05771077
13indolalkylamine catabolic process (GO:0046218)6.05771077
14hormone catabolic process (GO:0042447)6.00393405
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86530648
16cysteine metabolic process (GO:0006534)5.85119256
17kynurenine metabolic process (GO:0070189)5.80228330
18tryptophan metabolic process (GO:0006568)5.71569279
19regulation of guanylate cyclase activity (GO:0031282)5.68431263
20intestinal absorption (GO:0050892)5.54498468
21lysine catabolic process (GO:0006554)5.51564361
22lysine metabolic process (GO:0006553)5.51564361
23bile acid biosynthetic process (GO:0006699)5.49290461
24urea cycle (GO:0000050)5.46486625
25urea metabolic process (GO:0019627)5.46486625
26lipoprotein transport (GO:0042953)5.43290098
27alpha-linolenic acid metabolic process (GO:0036109)5.30293518
28serine family amino acid catabolic process (GO:0009071)5.24234964
29sulfur amino acid catabolic process (GO:0000098)5.21485077
30very-low-density lipoprotein particle assembly (GO:0034379)5.19072960
31homocysteine metabolic process (GO:0050667)5.18266185
32omega-hydroxylase P450 pathway (GO:0097267)5.14773869
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.13387748
34nitrogen cycle metabolic process (GO:0071941)5.04958685
35alkaloid metabolic process (GO:0009820)4.99859983
36high-density lipoprotein particle remodeling (GO:0034375)4.99225569
37amino-acid betaine metabolic process (GO:0006577)4.88096292
38aromatic amino acid family metabolic process (GO:0009072)4.87252999
39drug catabolic process (GO:0042737)4.79225690
40negative regulation of fibrinolysis (GO:0051918)4.77461234
41bile acid metabolic process (GO:0008206)4.72910929
42drug transmembrane transport (GO:0006855)4.71879598
43urate metabolic process (GO:0046415)4.64643711
44alpha-amino acid catabolic process (GO:1901606)4.62965552
45cellular ketone body metabolic process (GO:0046950)4.62891350
46peptidyl-glutamic acid carboxylation (GO:0017187)4.62308870
47protein carboxylation (GO:0018214)4.62308870
48regulation of triglyceride catabolic process (GO:0010896)4.61367702
49regulation of cholesterol esterification (GO:0010872)4.55632015
50regulation of fibrinolysis (GO:0051917)4.53848102
51tyrosine metabolic process (GO:0006570)4.49844769
52negative regulation of sterol transport (GO:0032372)4.48150932
53negative regulation of cholesterol transport (GO:0032375)4.48150932
54diacylglycerol metabolic process (GO:0046339)4.45116025
55serine family amino acid metabolic process (GO:0009069)4.43231911
56regulation of protein activation cascade (GO:2000257)4.41931524
57reverse cholesterol transport (GO:0043691)4.41678405
58complement activation, alternative pathway (GO:0006957)4.41475705
59glutamate metabolic process (GO:0006536)4.40864311
60plasma lipoprotein particle remodeling (GO:0034369)4.36484042
61protein-lipid complex remodeling (GO:0034368)4.36484042
62macromolecular complex remodeling (GO:0034367)4.36484042
63cellular modified amino acid catabolic process (GO:0042219)4.33709147
64cellular amino acid catabolic process (GO:0009063)4.33294542
65cellular glucuronidation (GO:0052695)4.32710430
66acylglycerol homeostasis (GO:0055090)4.30031485
67triglyceride homeostasis (GO:0070328)4.30031485
68indolalkylamine metabolic process (GO:0006586)4.29661617
69phospholipid efflux (GO:0033700)4.29045389
70regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.25879058
71endocrine process (GO:0050886)4.25879058
72regulation of systemic arterial blood pressure by hormone (GO:0001990)4.25879058
73positive regulation of guanylate cyclase activity (GO:0031284)4.19819552
74glycine metabolic process (GO:0006544)4.18232503
75benzene-containing compound metabolic process (GO:0042537)4.16511333
76short-chain fatty acid metabolic process (GO:0046459)4.15851336
77serine family amino acid biosynthetic process (GO:0009070)4.14891739
78amine catabolic process (GO:0009310)4.13849016
79cellular biogenic amine catabolic process (GO:0042402)4.13849016
80regulation of complement activation (GO:0030449)4.10393806
81protein-lipid complex assembly (GO:0065005)4.09233255
82bile acid and bile salt transport (GO:0015721)4.08564732
83exogenous drug catabolic process (GO:0042738)4.06692725
84phenylpropanoid metabolic process (GO:0009698)4.03460022
85coenzyme catabolic process (GO:0009109)4.00553183
86aspartate family amino acid catabolic process (GO:0009068)4.00268437
87ketone body metabolic process (GO:1902224)4.00247841
88drug transport (GO:0015893)3.99359531
89plasma lipoprotein particle clearance (GO:0034381)3.96708727
90renal system process involved in regulation of blood volume (GO:0001977)3.96513254
91ethanol oxidation (GO:0006069)3.96111850
92dicarboxylic acid biosynthetic process (GO:0043650)3.95638674
93glucuronate metabolic process (GO:0019585)3.95004066
94uronic acid metabolic process (GO:0006063)3.95004066
95aldehyde catabolic process (GO:0046185)3.94586944
96flavonoid metabolic process (GO:0009812)3.90807178
97acetyl-CoA metabolic process (GO:0006084)3.90490182
98arginine metabolic process (GO:0006525)3.88194584
99cholesterol efflux (GO:0033344)3.87530942
100lipoprotein metabolic process (GO:0042157)3.84909040
101organic acid catabolic process (GO:0016054)3.84641588
102carboxylic acid catabolic process (GO:0046395)3.84641588
103regulation of systemic arterial blood pressure (GO:0003073)3.81410438
104plasma lipoprotein particle assembly (GO:0034377)3.79588115
105regulation of cholesterol homeostasis (GO:2000188)3.78932350
106positive regulation of lipid catabolic process (GO:0050996)3.77957593
1072-oxoglutarate metabolic process (GO:0006103)3.76725039
108regulation of bile acid biosynthetic process (GO:0070857)3.73476758
109imidazole-containing compound metabolic process (GO:0052803)3.73159123
110oxidative demethylation (GO:0070989)3.72672619
111fatty acid beta-oxidation (GO:0006635)3.70280818
112adhesion of symbiont to host cell (GO:0044650)3.69833840
113virion attachment to host cell (GO:0019062)3.69833840
114drug metabolic process (GO:0017144)3.69731516
115positive regulation of triglyceride lipase activity (GO:0061365)3.69452424
116positive regulation of lipoprotein lipase activity (GO:0051006)3.69452424
117carnitine metabolic process (GO:0009437)3.69422483
118ethanol metabolic process (GO:0006067)3.68874736
119glutamine family amino acid biosynthetic process (GO:0009084)3.68641823
120cholesterol homeostasis (GO:0042632)3.67270938
121fatty acid oxidation (GO:0019395)3.66907433
122phospholipid homeostasis (GO:0055091)3.65486343
123sterol homeostasis (GO:0055092)3.64587515
124vitamin biosynthetic process (GO:0009110)3.63987100
125monocarboxylic acid catabolic process (GO:0072329)3.61170651
126response to nitrosative stress (GO:0051409)3.60609471
127lipid oxidation (GO:0034440)3.59749544
128low-density lipoprotein particle remodeling (GO:0034374)3.58653319
129* fructose metabolic process (GO:0006000)3.55774953
130regulation of cellular extravasation (GO:0002691)3.55143739
131peptide catabolic process (GO:0043171)3.54617982
132plasma lipoprotein particle organization (GO:0071827)3.52913313
133vitamin transport (GO:0051180)3.52712344
134peptide hormone processing (GO:0016486)3.51484218
135* NADH metabolic process (GO:0006734)3.50562935
136complement activation, classical pathway (GO:0006958)3.48391684
137regulation of cGMP biosynthetic process (GO:0030826)3.48293383
138proline metabolic process (GO:0006560)3.43794481
139receptor guanylyl cyclase signaling pathway (GO:0007168)3.43750397
140midgut development (GO:0007494)3.43129872
141fat-soluble vitamin metabolic process (GO:0006775)3.39377576
142heme transport (GO:0015886)3.36512063
143protein-lipid complex subunit organization (GO:0071825)3.35357620
144maintenance of gastrointestinal epithelium (GO:0030277)3.34392801
145L-ascorbic acid metabolic process (GO:0019852)3.31209826
146renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.30817551
147positive regulation of fatty acid biosynthetic process (GO:0045723)3.30638945
148adhesion of symbiont to host (GO:0044406)3.29944534
149glycolipid catabolic process (GO:0019377)3.21383294
150digestion (GO:0007586)3.21127387
151vitamin transmembrane transport (GO:0035461)3.20852324
152oxaloacetate metabolic process (GO:0006107)3.20479981
153glycosphingolipid catabolic process (GO:0046479)3.20081771
154complement activation (GO:0006956)3.18526967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.20135278
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09598547
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47726950
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.35025975
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.03244416
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93905315
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.68982355
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.88016598
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.75750816
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.79824360
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.39615447
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16815960
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11484763
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.02160747
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00070869
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5242657
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86213208
18CLOCK_20551151_ChIP-Seq_293T_Human1.72887484
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.65827808
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54962184
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.54135821
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36315395
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34606386
24GATA1_22025678_ChIP-Seq_K562_Human1.30466158
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29211457
26HTT_18923047_ChIP-ChIP_STHdh_Human1.21864174
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.18712626
28SA1_27219007_Chip-Seq_Bcells_Human1.17460042
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16260338
30GATA4_25053715_ChIP-Seq_YYC3_Human1.15536053
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13002832
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12565966
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11979494
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.11019353
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09578134
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08446069
37BCOR_27268052_Chip-Seq_Bcells_Human1.08359681
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.07086933
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05615252
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05595201
41BCL6_27268052_Chip-Seq_Bcells_Human1.05539192
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04902557
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.04764293
44CTCF_27219007_Chip-Seq_Bcells_Human1.04266622
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01969260
46JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01286210
47IRF8_21731497_ChIP-ChIP_J774_Mouse0.97694716
48DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93602210
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92453845
50ESR2_21235772_ChIP-Seq_MCF-7_Human0.92357312
51ESR1_21235772_ChIP-Seq_MCF-7_Human0.87433600
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86775219
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86724005
54NANOG_20526341_ChIP-Seq_ESCs_Human0.83726984
55ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83182044
56P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82103659
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81605665
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80963020
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79719345
60IRF8_22096565_ChIP-ChIP_GC-B_Human0.79440956
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79192211
62KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77644911
63SOX2_21211035_ChIP-Seq_LN229_Human0.76800287
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76560966
65GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76063173
66* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75926801
67KLF5_25053715_ChIP-Seq_YYC3_Human0.75571248
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75199966
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75176019
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74572616
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74230364
72ZNF263_19887448_ChIP-Seq_K562_Human0.74050767
73HNFA_21074721_ChIP-Seq_CACO-2_Human0.73230837
74* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72695672
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71992116
76GATA6_25053715_ChIP-Seq_YYC3_Human0.71710622
77OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71677996
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71198106
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70562713
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70219118
81SOX2_22085726_ChIP-Seq_NPCs_Mouse0.69967337
82RXR_22108803_ChIP-Seq_LS180_Human0.69655723
83CTCF_20526341_ChIP-Seq_ESCs_Human0.69441732
84TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69303717
85LXR_22292898_ChIP-Seq_THP-1_Human0.69074118
86P300_27268052_Chip-Seq_Bcells_Human0.68887510
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68750829
88* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68442029
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68317870
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68059412
91* RARA_24833708_ChIP-Seq_LIVER_Mouse0.67446972
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67054781
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66857823
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66278741
95EGR1_19032775_ChIP-ChIP_M12_Human0.66210902
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63002567
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63002567
98CEBPB_22108803_ChIP-Seq_LS180_Human0.62648474
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62235717
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.61482149
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58724235
102MYC_19915707_ChIP-ChIP_AK7_Human0.57888777
103AR_20517297_ChIP-Seq_VCAP_Human0.57365386
104SOX2_20726797_ChIP-Seq_SW620_Human0.57132598
105FOXA1_25552417_ChIP-Seq_VCAP_Human0.55024858
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53896111
107STAT1_17558387_ChIP-Seq_HELA_Human0.53464978
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53435888
109* RARB_24833708_ChIP-Seq_LIVER_Mouse0.52687328
110GATA2_19941826_ChIP-Seq_K562_Human0.51270694
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.51100240
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51075856
113CBP_21632823_ChIP-Seq_H3396_Human0.50717235
114TAF2_19829295_ChIP-Seq_ESCs_Human0.48750810
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47716702
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47621440
117RACK7_27058665_Chip-Seq_MCF-7_Human0.46575786
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.46487359
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.46020783
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.45795940
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45268373
122GATA1_19941826_ChIP-Seq_K562_Human0.44809523
123CDX2_22108803_ChIP-Seq_LS180_Human0.44493178
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.44429349
125P53_21459846_ChIP-Seq_SAOS-2_Human0.44308985
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43945074
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42263175
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41849021
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.40421058
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.40326064
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.40230980
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40149031
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.39466057
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39357026
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.39066766
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.39056739
137BCAT_22108803_ChIP-Seq_LS180_Human0.39055342
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.38805062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.33499260
2MP0002139_abnormal_hepatobiliary_system8.09327140
3MP0005085_abnormal_gallbladder_physiolo5.95509589
4MP0005365_abnormal_bile_salt5.72643655
5MP0008875_abnormal_xenobiotic_pharmacok5.00378692
6MP0003252_abnormal_bile_duct3.90990799
7MP0003806_abnormal_nucleotide_metabolis3.87221480
8MP0010329_abnormal_lipoprotein_level3.33007752
9MP0005332_abnormal_amino_acid3.29032351
10MP0003183_abnormal_peptide_metabolism3.15733224
11MP0009840_abnormal_foam_cell3.05349562
12MP0003195_calcinosis3.03008977
13MP0004019_abnormal_vitamin_homeostasis2.86684284
14MP0001666_abnormal_nutrient_absorption2.77743054
15MP0009379_abnormal_foot_pigmentation2.68736293
16MP0005083_abnormal_biliary_tract2.59295497
17MP0002138_abnormal_hepatobiliary_system2.35958727
18MP0003191_abnormal_cellular_cholesterol2.18004631
19MP0010155_abnormal_intestine_physiology2.05799402
20MP0000609_abnormal_liver_physiology1.99995676
21MP0002118_abnormal_lipid_homeostasis1.99126105
22MP0009643_abnormal_urine_homeostasis1.82210031
23MP0005319_abnormal_enzyme/_coenzyme1.80409641
24MP0001764_abnormal_homeostasis1.64450117
25MP0005584_abnormal_enzyme/coenzyme_acti1.64148083
26MP0005409_darkened_coat_color1.63503638
27MP0003868_abnormal_feces_composition1.61261745
28MP0005451_abnormal_body_composition1.60470372
29MP0005636_abnormal_mineral_homeostasis1.39837487
30MP0004043_abnormal_pH_regulation1.39017671
31MP0003186_abnormal_redox_activity1.37665091
32MP0001664_abnormal_digestion1.33431175
33MP0003866_abnormal_defecation1.32676998
34MP0009697_abnormal_copulation1.26727152
35MP0003879_abnormal_hair_cell1.21074363
36MP0003011_delayed_dark_adaptation1.17147609
37MP0000490_abnormal_crypts_of1.14018053
38MP0001756_abnormal_urination1.10438530
39MP0000598_abnormal_liver_morphology1.10001263
40MP0000678_abnormal_parathyroid_gland1.08821944
41MP0003705_abnormal_hypodermis_morpholog1.02257944
42MP0005084_abnormal_gallbladder_morpholo1.01323560
43MP0003656_abnormal_erythrocyte_physiolo1.01245194
44MP0009764_decreased_sensitivity_to0.99992812
45MP0010352_gastrointestinal_tract_polyps0.99130835
46MP0000477_abnormal_intestine_morphology0.97825828
47MP0002136_abnormal_kidney_physiology0.95650553
48MP0000604_amyloidosis0.95037853
49MP0006036_abnormal_mitochondrial_physio0.93862506
50MP0009642_abnormal_blood_homeostasis0.89769372
51MP0002876_abnormal_thyroid_physiology0.89448494
52MP0005647_abnormal_sex_gland0.86956373
53MP0001765_abnormal_ion_homeostasis0.86033857
54MP0009763_increased_sensitivity_to0.85358258
55MP0008469_abnormal_protein_level0.84097880
56MP0002254_reproductive_system_inflammat0.83787809
57MP0000462_abnormal_digestive_system0.82751936
58MP0001188_hyperpigmentation0.82683833
59MP0005670_abnormal_white_adipose0.81979725
60MP0001663_abnormal_digestive_system0.81037823
61MP0004858_abnormal_nervous_system0.80456049
62MP0005408_hypopigmentation0.80321933
63MP0002078_abnormal_glucose_homeostasis0.76544451
64MP0005376_homeostasis/metabolism_phenot0.74312845
65MP0009785_altered_susceptibility_to0.74144822
66MP0009765_abnormal_xenobiotic_induced0.72985712
67MP0001873_stomach_inflammation0.71976761
68MP0005535_abnormal_body_temperature0.71562848
69MP0005220_abnormal_exocrine_pancreas0.69932731
70MP0002971_abnormal_brown_adipose0.66956134
71MP0005381_digestive/alimentary_phenotyp0.66120396
72MP0001501_abnormal_sleep_pattern0.65468208
73MP0001661_extended_life_span0.64306122
74MP0004270_analgesia0.63215201
75MP0000249_abnormal_blood_vessel0.61881488
76MP0005266_abnormal_metabolism0.61377222
77MP0009053_abnormal_anal_canal0.61207123
78MP0010368_abnormal_lymphatic_system0.60562001
79MP0005334_abnormal_fat_pad0.60386224
80MP0003329_amyloid_beta_deposits0.59058525
81MP0006035_abnormal_mitochondrial_morpho0.57710686
82MP0002928_abnormal_bile_duct0.57455911
83MP0004264_abnormal_extraembryonic_tissu0.55753955
84MP0003638_abnormal_response/metabolism_0.54716453
85MP0005058_abnormal_lysosome_morphology0.53689204
86MP0005395_other_phenotype0.52975023
87MP0000538_abnormal_urinary_bladder0.52573929
88MP0010234_abnormal_vibrissa_follicle0.52462640
89MP0005448_abnormal_energy_balance0.51869848
90MP0004130_abnormal_muscle_cell0.51563012
91MP0003690_abnormal_glial_cell0.51333319
92MP0005666_abnormal_adipose_tissue0.50919467
93MP0003300_gastrointestinal_ulcer0.50662136
94MP0005025_abnormal_response_to0.50590201
95MP0000230_abnormal_systemic_arterial0.50392896
96MP0002098_abnormal_vibrissa_morphology0.49456695
97MP0002822_catalepsy0.48990405
98MP0002796_impaired_skin_barrier0.46646546
99MP0003953_abnormal_hormone_level0.44238514
100MP0003718_maternal_effect0.44132657
101MP0002168_other_aberrant_phenotype0.42839790
102MP0008873_increased_physiological_sensi0.41294995
103MP0001835_abnormal_antigen_presentation0.40545689
104MP0008872_abnormal_physiological_respon0.40419424
105MP0001881_abnormal_mammary_gland0.39294137
106MP0000639_abnormal_adrenal_gland0.38709655
107MP0003303_peritoneal_inflammation0.38573104
108MP0002166_altered_tumor_susceptibility0.38397280
109MP0005464_abnormal_platelet_physiology0.37717013
110MP0004147_increased_porphyrin_level0.37509758
111MP0002135_abnormal_kidney_morphology0.37208041
112MP0008874_decreased_physiological_sensi0.36961725
113MP0005166_decreased_susceptibility_to0.36903632
114MP0003724_increased_susceptibility_to0.36365598
115MP0009333_abnormal_splenocyte_physiolog0.36128897
116MP0000537_abnormal_urethra_morphology0.35687279
117MP0001485_abnormal_pinna_reflex0.35614046
118MP0003075_altered_response_to0.35095115
119MP0009115_abnormal_fat_cell0.32721860
120MP0008961_abnormal_basal_metabolism0.32278763
121MP0009672_abnormal_birth_weight0.32261104
122MP0000566_synostosis0.31943529
123MP0002896_abnormal_bone_mineralization0.31930966
124MP0004782_abnormal_surfactant_physiolog0.31306398
125MP0001845_abnormal_inflammatory_respons0.29392886
126MP0009384_cardiac_valve_regurgitation0.28682410
127MP0005167_abnormal_blood-brain_barrier0.27519917
128MP0005248_abnormal_Harderian_gland0.26204594
129MP0002837_dystrophic_cardiac_calcinosis0.25111888
130MP0003959_abnormal_lean_body0.24372837
131MP0003436_decreased_susceptibility_to0.24367973
132MP0006082_CNS_inflammation0.23853788

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83314578
2Intrahepatic cholestasis (HP:0001406)6.47524148
3Deep venous thrombosis (HP:0002625)6.18671710
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.15048659
5Hypobetalipoproteinemia (HP:0003563)5.93593593
6Xanthomatosis (HP:0000991)5.89186315
7Prolonged partial thromboplastin time (HP:0003645)5.28499601
8Abnormality of glutamine family amino acid metabolism (HP:0010902)5.24737876
9Hyperglycinuria (HP:0003108)4.79478254
10Hyperammonemia (HP:0001987)4.72188152
11Hyperlipoproteinemia (HP:0010980)4.65843776
12Ketosis (HP:0001946)4.51565242
13Abnormality of glycine metabolism (HP:0010895)4.48631945
14Abnormality of serine family amino acid metabolism (HP:0010894)4.48631945
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.47265996
16Hyperglycinemia (HP:0002154)4.46196512
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.32776607
18Hypolipoproteinemia (HP:0010981)4.30760488
19Abnormality of the vitamin B12 metabolism (HP:0004341)4.26589553
20Complement deficiency (HP:0004431)4.16553693
21Widely patent fontanelles and sutures (HP:0004492)4.14620565
22Chronic diarrhea (HP:0002028)4.05249941
23Joint hemorrhage (HP:0005261)4.04436017
24Abnormality of vitamin B metabolism (HP:0004340)4.00088896
25Epidermoid cyst (HP:0200040)3.99905724
26Gout (HP:0001997)3.99488211
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89362107
28Fat malabsorption (HP:0002630)3.88286374
29Abnormality of methionine metabolism (HP:0010901)3.82552584
30Hypoglycemic coma (HP:0001325)3.77103977
31Ileus (HP:0002595)3.73216451
32Abnormality of the common coagulation pathway (HP:0010990)3.71733191
33Abnormality of fatty-acid metabolism (HP:0004359)3.71203111
34Ketoacidosis (HP:0001993)3.63411189
35Abnormality of pyrimidine metabolism (HP:0004353)3.62240308
36Hypoalphalipoproteinemia (HP:0003233)3.56804104
37Conjugated hyperbilirubinemia (HP:0002908)3.52072306
38* Abnormality of nucleobase metabolism (HP:0010932)3.36770256
39Delayed CNS myelination (HP:0002188)3.28607933
40Hypercholesterolemia (HP:0003124)3.26027516
41Facial shape deformation (HP:0011334)3.23788757
42Potter facies (HP:0002009)3.23788757
43* Abnormality of purine metabolism (HP:0004352)3.23428800
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21191917
45Abnormality of the intrinsic pathway (HP:0010989)3.09841707
46Abnormality of serum amino acid levels (HP:0003112)3.08502153
47Pigmentary retinal degeneration (HP:0001146)3.02113161
48Alkalosis (HP:0001948)3.00807447
49Wide cranial sutures (HP:0010537)2.99685168
50Abnormality of complement system (HP:0005339)2.99332435
51Hemorrhage of the eye (HP:0011885)2.98567827
52* Metabolic acidosis (HP:0001942)2.96310839
53Nephritis (HP:0000123)2.93555625
54Metabolic alkalosis (HP:0200114)2.93175729
55Hepatocellular carcinoma (HP:0001402)2.92353956
56* Malnutrition (HP:0004395)2.91328359
57* Hyperbilirubinemia (HP:0002904)2.90617331
58Vascular calcification (HP:0004934)2.90499151
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90407886
60Dicarboxylic aciduria (HP:0003215)2.90407886
61Generalized aminoaciduria (HP:0002909)2.89061959
62Thin bony cortex (HP:0002753)2.77589771
63Megaloblastic anemia (HP:0001889)2.76777031
64* Lethargy (HP:0001254)2.72962991
65Abdominal distention (HP:0003270)2.71316266
66Steatorrhea (HP:0002570)2.70259899
67Hydroxyprolinuria (HP:0003080)2.66614554
68Abnormality of proline metabolism (HP:0010907)2.66614554
69Acanthocytosis (HP:0001927)2.59505145
70Cardiovascular calcification (HP:0011915)2.57060834
71Irritability (HP:0000737)2.54508888
72Spastic diplegia (HP:0001264)2.48089905
73Cerebral edema (HP:0002181)2.45685708
74Skin nodule (HP:0200036)2.41834062
75Congenital sensorineural hearing impairment (HP:0008527)2.41465471
76Hypotension (HP:0002615)2.41039307
77Cholecystitis (HP:0001082)2.40345782
78Abnormal gallbladder physiology (HP:0012438)2.40345782
79Spontaneous abortion (HP:0005268)2.40326295
80Focal segmental glomerulosclerosis (HP:0000097)2.40025333
81Neonatal onset (HP:0003623)2.39542905
82Enlarged kidneys (HP:0000105)2.39278842
83Myocardial infarction (HP:0001658)2.38776054
84Rickets (HP:0002748)2.38110117
85Late onset (HP:0003584)2.37497968
86* Vomiting (HP:0002013)2.35696925
87Hypoglycemic seizures (HP:0002173)2.30182023
88Sensorimotor neuropathy (HP:0007141)2.29480302
89Systemic lupus erythematosus (HP:0002725)2.27927013
90Hypochromic microcytic anemia (HP:0004840)2.24813881
91* Abnormality of urine glucose concentration (HP:0011016)2.22623475
92* Glycosuria (HP:0003076)2.22623475
93* Hyperuricemia (HP:0002149)2.22359229
94* Increased purine levels (HP:0004368)2.22359229
95Pancreatitis (HP:0001733)2.22000906
96Decreased circulating renin level (HP:0003351)2.20624852
97Cerebral palsy (HP:0100021)2.19999725
98Abnormal gallbladder morphology (HP:0012437)2.19260755
99Cholelithiasis (HP:0001081)2.16726462
100* Proximal tubulopathy (HP:0000114)2.16339733
101* Hypophosphatemia (HP:0002148)2.13664552
102Hypokalemic alkalosis (HP:0001949)2.13621872
103Abnormal enzyme/coenzyme activity (HP:0012379)2.12743153
104Nephrolithiasis (HP:0000787)2.11498922
105Protuberant abdomen (HP:0001538)2.09018358
106Esophageal varix (HP:0002040)2.08057118
107Abnormality of renin-angiotensin system (HP:0000847)2.06628344
108Abnormality of magnesium homeostasis (HP:0004921)2.05791116
109Mitral stenosis (HP:0001718)2.04846882
110Glomerulonephritis (HP:0000099)2.03326581
111Posterior subcapsular cataract (HP:0007787)2.02809797
112Confusion (HP:0001289)2.01130188
113Hyperactive renin-angiotensin system (HP:0000841)1.99846182
114Hyperparathyroidism (HP:0000843)1.98729910
115Delayed epiphyseal ossification (HP:0002663)1.96518538
116Abnormal cartilage morphology (HP:0002763)1.94588058
117Osteomalacia (HP:0002749)1.94446042
118Hypophosphatemic rickets (HP:0004912)1.94206907
119Enlarged epiphyses (HP:0010580)1.93963960
120Recurrent gram-negative bacterial infections (HP:0005420)1.93942897
121Brushfield spots (HP:0001088)1.93326578
122Opisthotonus (HP:0002179)1.93133557
123Eczematoid dermatitis (HP:0000976)1.92059442
124Abnormality of vitamin metabolism (HP:0100508)1.90966474
125Amyloidosis (HP:0011034)1.90264706
126Abnormality of alkaline phosphatase activity (HP:0004379)1.89898478
127Increased circulating renin level (HP:0000848)1.89179216
128Poikilocytosis (HP:0004447)1.87347051
129Glomerulosclerosis (HP:0000096)1.87010796
130Hyperinsulinemic hypoglycemia (HP:0000825)1.85795888
131Abnormality of the gallbladder (HP:0005264)1.84863494
132Menorrhagia (HP:0000132)1.83181580
133Villous atrophy (HP:0011473)1.83181019
134Abnormality of small intestinal villus morphology (HP:0011472)1.83181019
135Elevated alkaline phosphatase (HP:0003155)1.82973490
136Gingivitis (HP:0000230)1.77142597
137Abnormal glucose tolerance (HP:0001952)1.74914222
138* Abnormal urine phosphate concentration (HP:0012599)1.69748393
139Hypokalemia (HP:0002900)1.64776555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.40387767
2BCKDK6.79811427
3FGFR43.84187290
4ERN13.71360961
5SIK13.49613152
6WNK43.36340728
7WNK33.13205365
8MST1R2.79743417
9OXSR12.77183624
10INSRR2.50335754
11EPHA22.42634450
12TAOK32.37357715
13ERBB42.33709159
14FRK2.14740108
15TESK21.94336717
16PKN21.94288036
17STK38L1.80292969
18MAP2K41.78240554
19MAPK111.77175752
20LATS11.62169936
21PTK61.55701105
22PRPF4B1.53953909
23GRK61.52457375
24MAP4K11.48317030
25MAP3K121.47514866
26TRIB31.46204145
27FLT31.44800973
28ABL21.37600975
29PIK3CG1.37046017
30STK391.28942325
31TYK21.25798649
32MAP3K71.25255382
33DDR21.25080740
34PRKAA21.18928154
35MYLK1.18455048
36NEK91.13958076
37MAP3K31.13559273
38PINK11.12714852
39DAPK21.10302384
40KDR1.10221248
41MATK1.09323314
42RIPK41.09224713
43PIK3CA1.06950874
44PDK31.05999544
45PDK41.05999544
46AKT31.03035987
47MET1.01933001
48TNIK0.99849483
49MAP3K100.99307217
50JAK20.98008558
51EPHB10.96358911
52TESK10.95180881
53SGK4940.94385078
54SGK2230.94385078
55RIPK10.90443439
56GSK3A0.88687162
57MAP2K30.87957682
58MAP3K110.87615261
59FGFR20.86732817
60SGK30.86344338
61ERBB20.85747175
62NLK0.85606496
63CDC42BPA0.84626144
64NEK10.84254951
65PRKCZ0.83742801
66TBK10.82449412
67DYRK1B0.81991710
68MAP3K140.81147391
69STK240.81058754
70PRKAA10.80421414
71PTK20.79125754
72TIE10.77895621
73MAPK40.77866576
74MAP2K60.74210177
75MST40.71797588
76PRKACG0.71745660
77JAK10.67657100
78IRAK30.67328109
79TAOK10.67299267
80SGK20.67044453
81PDPK10.62139115
82FER0.62076821
83CDK60.61975481
84PDK20.61600660
85MAPK150.61343657
86KSR20.60090271
87CSK0.59879237
88TGFBR20.58767726
89CAMK2G0.54363835
90MAP2K20.54059820
91MAPK120.53735268
92SRC0.51340525
93ZAP700.50241316
94PIM10.48076913
95STK380.47941589
96PBK0.47440591
97MAP3K20.47301709
98PRKG20.47279409
99LMTK20.47016507
100PDGFRA0.46418387
101IRAK10.45470154
102CAMK1D0.43974146
103PRKCQ0.42888253
104MAP2K10.41710558
105FYN0.40321413
106PDK10.39375810
107GRK10.38405074
108PRKCD0.38049109
109CAMK2D0.36893908
110YES10.33570828
111IGF1R0.32905513
112MAP3K50.32404921
113PAK40.32071369
114PRKACA0.31939204
115BMX0.31848809
116EPHA30.31454619
117CSNK1G10.30748229
118PAK30.30686360
119EPHB20.30563040
120BMPR20.30495472
121FGFR30.29620740
122IKBKE0.29347834
123CAMK2B0.29256775
124CASK0.28803069
125PRKCA0.28207201
126ITK0.26761143
127CDK40.26202440
128JAK30.25527162
129MAPK70.25403699
130SMG10.25319044
131SYK0.25302434
132MTOR0.25280420
133MAP3K10.24543159
134MAP3K60.24250017
135ICK0.23712198
136RET0.23648192
137EPHA40.23635516
138CAMK40.23624452
139CSF1R0.23423805
140KIT0.22026697
141BTK0.21843989
142LCK0.21710955
143PRKG10.21478712

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.91411679
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55987173
3Nitrogen metabolism_Homo sapiens_hsa009103.41040298
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15081380
5Arginine biosynthesis_Homo sapiens_hsa002202.91871387
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76101916
7Tryptophan metabolism_Homo sapiens_hsa003802.69050352
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59064776
9Fatty acid degradation_Homo sapiens_hsa000712.56756386
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54996688
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49213449
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46783032
13Butanoate metabolism_Homo sapiens_hsa006502.41618129
14Complement and coagulation cascades_Homo sapiens_hsa046102.19882034
15Peroxisome_Homo sapiens_hsa041462.16669886
16Propanoate metabolism_Homo sapiens_hsa006402.14557928
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08710659
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95317940
19Histidine metabolism_Homo sapiens_hsa003401.88103016
20PPAR signaling pathway_Homo sapiens_hsa033201.85350354
21Fatty acid metabolism_Homo sapiens_hsa012121.85168715
22Chemical carcinogenesis_Homo sapiens_hsa052041.83800936
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83243645
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81538127
25beta-Alanine metabolism_Homo sapiens_hsa004101.79884683
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.71918765
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.64584381
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63531715
29Bile secretion_Homo sapiens_hsa049761.62823211
30Pyruvate metabolism_Homo sapiens_hsa006201.62409377
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62097162
32Retinol metabolism_Homo sapiens_hsa008301.56703803
33Selenocompound metabolism_Homo sapiens_hsa004501.54617662
34Sulfur metabolism_Homo sapiens_hsa009201.53227710
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.51321693
36Caffeine metabolism_Homo sapiens_hsa002321.47440965
37Phenylalanine metabolism_Homo sapiens_hsa003601.46387455
38Starch and sucrose metabolism_Homo sapiens_hsa005001.44450434
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36888691
40Folate biosynthesis_Homo sapiens_hsa007901.34427636
41Fat digestion and absorption_Homo sapiens_hsa049751.32442430
42Staphylococcus aureus infection_Homo sapiens_hsa051501.32005703
43Vitamin digestion and absorption_Homo sapiens_hsa049771.28478211
44Fatty acid elongation_Homo sapiens_hsa000621.26967780
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.26566854
46* Carbon metabolism_Homo sapiens_hsa012001.25570013
47Tyrosine metabolism_Homo sapiens_hsa003501.24118825
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20887420
49* Biosynthesis of amino acids_Homo sapiens_hsa012301.17667748
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16728197
51Arginine and proline metabolism_Homo sapiens_hsa003301.12209960
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.10767567
53ABC transporters_Homo sapiens_hsa020101.08572461
54Steroid biosynthesis_Homo sapiens_hsa001001.07165730
55Glutathione metabolism_Homo sapiens_hsa004800.96153761
56Lysine degradation_Homo sapiens_hsa003100.92432491
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90524724
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89800920
59Sulfur relay system_Homo sapiens_hsa041220.82637946
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82609986
61Glycerolipid metabolism_Homo sapiens_hsa005610.80854575
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80560670
63* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77814380
64Vitamin B6 metabolism_Homo sapiens_hsa007500.68178226
65Asthma_Homo sapiens_hsa053100.62409736
66One carbon pool by folate_Homo sapiens_hsa006700.60241031
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53314187
68Ether lipid metabolism_Homo sapiens_hsa005650.51555055
69* Metabolic pathways_Homo sapiens_hsa011000.49503326
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.47825188
71* Pentose phosphate pathway_Homo sapiens_hsa000300.44493339
72Galactose metabolism_Homo sapiens_hsa000520.42257805
73Fatty acid biosynthesis_Homo sapiens_hsa000610.41023669
74Allograft rejection_Homo sapiens_hsa053300.39432022
75Sphingolipid metabolism_Homo sapiens_hsa006000.37385345
76Autoimmune thyroid disease_Homo sapiens_hsa053200.35346341
77Graft-versus-host disease_Homo sapiens_hsa053320.31813267
78Pancreatic secretion_Homo sapiens_hsa049720.30663062
79* Fructose and mannose metabolism_Homo sapiens_hsa000510.27862613
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25556256
81Pertussis_Homo sapiens_hsa051330.25308983
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21541447
83Insulin resistance_Homo sapiens_hsa049310.19848593
84Type I diabetes mellitus_Homo sapiens_hsa049400.18510180
85Renin-angiotensin system_Homo sapiens_hsa046140.18493701
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.17961358
87Mineral absorption_Homo sapiens_hsa049780.17443050
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14021305
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.12719086
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12249186
91Linoleic acid metabolism_Homo sapiens_hsa005910.11404900
92Prion diseases_Homo sapiens_hsa050200.10312737
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08638933
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08539798
95Renin secretion_Homo sapiens_hsa049240.07123012
96Antigen processing and presentation_Homo sapiens_hsa046120.05233710
97Glucagon signaling pathway_Homo sapiens_hsa049220.05101046
98Cocaine addiction_Homo sapiens_hsa050300.04608934
99Protein digestion and absorption_Homo sapiens_hsa049740.04602758
100Serotonergic synapse_Homo sapiens_hsa047260.03289590
101AMPK signaling pathway_Homo sapiens_hsa041520.01448921
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00598987
103Leishmaniasis_Homo sapiens_hsa051400.00042168
104African trypanosomiasis_Homo sapiens_hsa05143-0.2254260
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2217129
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2139342
107Bladder cancer_Homo sapiens_hsa05219-0.2040250
108Lysosome_Homo sapiens_hsa04142-0.2002732
109Regulation of autophagy_Homo sapiens_hsa04140-0.1920978
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1827200
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1780198
112Other glycan degradation_Homo sapiens_hsa00511-0.1464358
113Hepatitis C_Homo sapiens_hsa05160-0.1459700
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1449189
115Insulin signaling pathway_Homo sapiens_hsa04910-0.1370335
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0991085
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0556206
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0555003
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0257908
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0054253

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