ALDOC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)8.34660810
2cerebellar Purkinje cell layer development (GO:0021680)6.59374141
3cellular potassium ion homeostasis (GO:0030007)5.61486796
4L-amino acid import (GO:0043092)5.57500009
5locomotory exploration behavior (GO:0035641)5.56878439
6C4-dicarboxylate transport (GO:0015740)5.26639934
7sodium ion export (GO:0071436)5.22229891
8metanephric nephron tubule development (GO:0072234)5.10801631
9metanephric tubule development (GO:0072170)5.10801631
10amino acid import (GO:0043090)5.02434555
11synaptic vesicle maturation (GO:0016188)4.90806951
12neurotransmitter-gated ion channel clustering (GO:0072578)4.89515771
13positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.79470775
14negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.76458039
15gamma-aminobutyric acid transport (GO:0015812)4.68828066
16metanephric nephron epithelium development (GO:0072243)4.67163001
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61743697
18cell communication by electrical coupling (GO:0010644)4.58641769
19collecting duct development (GO:0072044)4.58615528
20neurofilament cytoskeleton organization (GO:0060052)4.55906772
21positive regulation of cardiac muscle hypertrophy (GO:0010613)4.44077967
22positive regulation of muscle hypertrophy (GO:0014742)4.44077967
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39287967
24synaptic vesicle exocytosis (GO:0016079)4.34198124
25positive regulation of dendritic spine morphogenesis (GO:0061003)4.31505093
26glutamate secretion (GO:0014047)4.31035173
27neuronal action potential propagation (GO:0019227)4.29253471
28metanephric epithelium development (GO:0072207)4.28264098
29response to auditory stimulus (GO:0010996)4.26541520
30multicellular organismal movement (GO:0050879)4.24655137
31musculoskeletal movement (GO:0050881)4.24655137
32alanine transport (GO:0032328)4.22974242
33regulation of beta-amyloid formation (GO:1902003)4.22093277
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.19276664
35inositol phosphate-mediated signaling (GO:0048016)4.18072428
36vocalization behavior (GO:0071625)4.13842356
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10382630
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08861990
39ionotropic glutamate receptor signaling pathway (GO:0035235)4.07377927
40relaxation of smooth muscle (GO:0044557)4.05992919
41potassium ion import (GO:0010107)4.03313207
42neurotransmitter secretion (GO:0007269)4.01370816
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01217076
44cerebellar granule cell differentiation (GO:0021707)4.00355367
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00063197
46negative regulation of astrocyte differentiation (GO:0048712)3.97593569
47auditory behavior (GO:0031223)3.96535461
48regulation of synaptic vesicle exocytosis (GO:2000300)3.96394111
49chemosensory behavior (GO:0007635)3.95555421
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.91104387
51glutamate receptor signaling pathway (GO:0007215)3.90650468
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.86962752
53layer formation in cerebral cortex (GO:0021819)3.86328773
54positive regulation of cellular amide metabolic process (GO:0034250)3.83160539
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.83095479
56retina layer formation (GO:0010842)3.78497943
57cellular sodium ion homeostasis (GO:0006883)3.77853233
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73088667
59synaptic transmission, glutamatergic (GO:0035249)3.72366787
60neurotransmitter uptake (GO:0001504)3.71656914
61acidic amino acid transport (GO:0015800)3.69438823
62exploration behavior (GO:0035640)3.68638420
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.67481807
64potassium ion homeostasis (GO:0055075)3.66161232
65transmission of nerve impulse (GO:0019226)3.64608828
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.64004226
67long-term memory (GO:0007616)3.63476318
68regulation of glutamate receptor signaling pathway (GO:1900449)3.62581805
69negative regulation of heart rate (GO:0010459)3.61889043
70regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.61523487
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.59808099
72relaxation of cardiac muscle (GO:0055119)3.58802948
73regulation of synaptic vesicle transport (GO:1902803)3.57813793
74regulation of amyloid precursor protein catabolic process (GO:1902991)3.54960858
75innervation (GO:0060384)3.54489890
76neuron cell-cell adhesion (GO:0007158)3.53389475
77proline transport (GO:0015824)3.50919171
78regulation of postsynaptic membrane potential (GO:0060078)3.50826271
79regulation of neuronal synaptic plasticity (GO:0048168)3.47360474
80regulation of potassium ion transmembrane transporter activity (GO:1901016)3.47169528
81membrane depolarization during action potential (GO:0086010)3.45921257
82retinal cone cell development (GO:0046549)3.45062873
83serotonin metabolic process (GO:0042428)3.44148301
84detection of calcium ion (GO:0005513)3.43720010
85aggressive behavior (GO:0002118)3.43369499
86neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.41139937
87neurotransmitter transport (GO:0006836)3.40020438
88L-glutamate transport (GO:0015813)3.39567984
89long term synaptic depression (GO:0060292)3.39414921
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.36894865
91negative regulation of dendrite morphogenesis (GO:0050774)3.35990386
92relaxation of muscle (GO:0090075)3.34865486
93positive regulation of potassium ion transmembrane transport (GO:1901381)3.34647323
94regulation of synapse structural plasticity (GO:0051823)3.34117111
95sodium ion homeostasis (GO:0055078)3.32803439
96neuron-neuron synaptic transmission (GO:0007270)3.31932284
97protein localization to synapse (GO:0035418)3.31633493
98regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30868438
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30687179
100membrane depolarization (GO:0051899)3.30535483
101regulation of potassium ion transmembrane transport (GO:1901379)3.28518391
102behavioral response to nicotine (GO:0035095)3.26914362
103neuromuscular process controlling posture (GO:0050884)3.25851927
104regulation of neurotransmitter levels (GO:0001505)3.25797708
105synaptic vesicle endocytosis (GO:0048488)3.25634814
106long-term synaptic potentiation (GO:0060291)3.24597857
107regulation of dendritic spine morphogenesis (GO:0061001)3.23799671
108neuromuscular process controlling balance (GO:0050885)3.21559695
109adult walking behavior (GO:0007628)3.20707326
110glycine transport (GO:0015816)3.19205162
111positive regulation of amino acid transport (GO:0051957)3.19205035
112glial cell proliferation (GO:0014009)3.18744314
113auditory receptor cell stereocilium organization (GO:0060088)3.16427049
114cerebellar Purkinje cell differentiation (GO:0021702)3.15460249
115mechanosensory behavior (GO:0007638)3.10628609
116postsynaptic membrane organization (GO:0001941)3.10609004
117regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07348693
118positive regulation of dendritic spine development (GO:0060999)3.07228027
119membrane repolarization (GO:0086009)3.06329678
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05020451
121negative regulation of norepinephrine secretion (GO:0010700)3.04662281
122response to histamine (GO:0034776)3.03509026
123endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.03462473
124regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00560633
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.99921611
126primary amino compound metabolic process (GO:1901160)2.99543892
127presynaptic membrane organization (GO:0097090)2.99531826
128regulation of neurotransmitter transport (GO:0051588)2.99229618
129regulation of synaptic plasticity (GO:0048167)2.95531153
130central nervous system myelination (GO:0022010)2.92422418
131axon ensheathment in central nervous system (GO:0032291)2.92422418
132dendrite morphogenesis (GO:0048813)2.92041941
133negative regulation of sodium ion transport (GO:0010766)2.90092920
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88143912
135regulation of cellular amide metabolic process (GO:0034248)2.86948808
136chondroitin sulfate catabolic process (GO:0030207)2.86116407
137low-density lipoprotein particle remodeling (GO:0034374)2.84226844
138regulation of respiratory system process (GO:0044065)2.82602352
139regulation of neurotransmitter secretion (GO:0046928)2.82510829
140ovulation cycle (GO:0042698)2.80739211
141atrial cardiac muscle cell action potential (GO:0086014)2.80127438
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80089550
143regulation of voltage-gated calcium channel activity (GO:1901385)2.79732124
144dendritic spine morphogenesis (GO:0060997)2.79637128
145cell differentiation in hindbrain (GO:0021533)2.79253002
146regulation of membrane repolarization (GO:0060306)2.78133836
147regulation of vesicle fusion (GO:0031338)2.78094304
148positive regulation of membrane potential (GO:0045838)2.75278432
149positive regulation of potassium ion transport (GO:0043268)2.75099231
150prepulse inhibition (GO:0060134)2.74836109
151positive regulation of synaptic transmission (GO:0050806)2.73494439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07501960
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30812772
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.27485458
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12557230
5TAF15_26573619_Chip-Seq_HEK293_Human3.05444771
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92224408
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.79923307
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78243300
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78243300
10VDR_22108803_ChIP-Seq_LS180_Human2.73514012
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68936704
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68220392
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63770179
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59568860
15GBX2_23144817_ChIP-Seq_PC3_Human2.58880265
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58143981
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53215119
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.51542417
19REST_21632747_ChIP-Seq_MESCs_Mouse2.51067238
20DROSHA_22980978_ChIP-Seq_HELA_Human2.49146534
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.33956749
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.33089784
23AR_21572438_ChIP-Seq_LNCaP_Human2.31905196
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.25303554
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19483954
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.16053148
27SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03786479
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.00694687
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94454205
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90327367
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.79260809
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74912133
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71994921
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57951677
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.43390376
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.41898622
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41707354
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40729561
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40032304
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39994940
41SMAD4_21799915_ChIP-Seq_A2780_Human1.39309391
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37458699
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37424340
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35683148
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34972647
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33415066
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31418868
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31038504
49FUS_26573619_Chip-Seq_HEK293_Human1.29835767
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.27767436
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26649007
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24214399
53AR_19668381_ChIP-Seq_PC3_Human1.22447143
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22389510
55RXR_22108803_ChIP-Seq_LS180_Human1.22349598
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22307644
57AR_25329375_ChIP-Seq_VCAP_Human1.22089223
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21554489
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19451885
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18216309
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17117807
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16667861
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.16151752
64P300_19829295_ChIP-Seq_ESCs_Human1.15756781
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15752820
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15416812
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14165697
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.13843513
69HTT_18923047_ChIP-ChIP_STHdh_Human1.12758516
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12469124
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12273957
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11324700
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10190626
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06840100
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06731978
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.06211573
77STAT3_23295773_ChIP-Seq_U87_Human1.04944454
78BCAT_22108803_ChIP-Seq_LS180_Human1.04319481
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03550028
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03272824
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03068226
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.01286301
83KDM2B_26808549_Chip-Seq_K562_Human1.01225816
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00436150
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.00061612
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99696644
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98622059
88ZNF274_21170338_ChIP-Seq_K562_Hela0.97645381
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97116442
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96513774
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.96249290
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95198912
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94900294
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94193744
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94094324
96SOX9_26525672_Chip-Seq_HEART_Mouse0.93957646
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93268060
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93086360
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.92028706
100TP53_16413492_ChIP-PET_HCT116_Human0.91966080
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91545812
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.90696516
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89676793
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88796113
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.88509452
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88218107
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87920459
108JUN_21703547_ChIP-Seq_K562_Human0.87663440
109TCF4_23295773_ChIP-Seq_U87_Human0.87394379
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.86416432
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86003162
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85098631
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85063523
114RUNX2_22187159_ChIP-Seq_PCA_Human0.84927667
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84913126
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83500070
117TP53_18474530_ChIP-ChIP_U2OS_Human0.83169492
118RNF2_27304074_Chip-Seq_NSC_Mouse0.82406270
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82084323
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81633840
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81133397
122AHR_22903824_ChIP-Seq_MCF-7_Human0.80992252
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80902658
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79704535
125OCT1_27270436_Chip-Seq_PROSTATE_Human0.79407377
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78881718
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.77511908
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77028294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.31319584
2MP0003635_abnormal_synaptic_transmissio3.63203968
3MP0009046_muscle_twitch3.43982606
4MP0003880_abnormal_central_pattern3.25849463
5MP0010386_abnormal_urinary_bladder3.24297565
6MP0009745_abnormal_behavioral_response3.05843259
7MP0002064_seizures2.98784848
8MP0003329_amyloid_beta_deposits2.94300146
9MP0001486_abnormal_startle_reflex2.87718103
10MP0003690_abnormal_glial_cell2.82356850
11MP0004270_analgesia2.81372603
12MP0002063_abnormal_learning/memory/cond2.79045402
13MP0005423_abnormal_somatic_nervous2.78035007
14MP0004858_abnormal_nervous_system2.75873807
15MP0005646_abnormal_pituitary_gland2.71791264
16MP0004885_abnormal_endolymph2.60510923
17MP0006035_abnormal_mitochondrial_morpho2.59060969
18MP0002572_abnormal_emotion/affect_behav2.58028935
19MP0008569_lethality_at_weaning2.52747876
20MP0002272_abnormal_nervous_system2.43263443
21MP0001968_abnormal_touch/_nociception2.32042220
22MP0001440_abnormal_grooming_behavior2.26625171
23MP0002734_abnormal_mechanical_nocicepti2.26331988
24MP0001501_abnormal_sleep_pattern2.13856690
25MP0009780_abnormal_chondrocyte_physiolo2.06096238
26MP0001502_abnormal_circadian_rhythm2.02941431
27MP0002736_abnormal_nociception_after1.99192235
28MP0001984_abnormal_olfaction1.98893057
29MP0002067_abnormal_sensory_capabilities1.95699807
30MP0002733_abnormal_thermal_nociception1.92933932
31MP0002557_abnormal_social/conspecific_i1.82548318
32MP0002909_abnormal_adrenal_gland1.76653504
33MP0008875_abnormal_xenobiotic_pharmacok1.76438765
34MP0003633_abnormal_nervous_system1.71720544
35MP0001970_abnormal_pain_threshold1.71478308
36MP0002254_reproductive_system_inflammat1.61086289
37MP0005645_abnormal_hypothalamus_physiol1.59966513
38MP0002638_abnormal_pupillary_reflex1.56378809
39MP0003075_altered_response_to1.55764097
40MP0004924_abnormal_behavior1.54759414
41MP0005386_behavior/neurological_phenoty1.54759414
42MP0004142_abnormal_muscle_tone1.53341317
43MP0003631_nervous_system_phenotype1.52186555
44MP0000778_abnormal_nervous_system1.51381088
45MP0002822_catalepsy1.50759617
46MP0003634_abnormal_glial_cell1.50040078
47MP0000604_amyloidosis1.49730087
48MP0003787_abnormal_imprinting1.44412883
49MP0003632_abnormal_nervous_system1.44009042
50MP0005551_abnormal_eye_electrophysiolog1.38696075
51MP0002735_abnormal_chemical_nociception1.37787165
52MP0000955_abnormal_spinal_cord1.37480195
53MP0002882_abnormal_neuron_morphology1.37249655
54MP0001485_abnormal_pinna_reflex1.35446771
55MP0002184_abnormal_innervation1.34159909
56MP0002066_abnormal_motor_capabilities/c1.33252360
57MP0003122_maternal_imprinting1.19822986
58MP0004484_altered_response_of1.19620262
59MP0004811_abnormal_neuron_physiology1.16098308
60MP0004036_abnormal_muscle_relaxation1.13498361
61MP0005377_hearing/vestibular/ear_phenot1.10990069
62MP0003878_abnormal_ear_physiology1.10990069
63MP0002090_abnormal_vision1.09188409
64MP0002152_abnormal_brain_morphology1.08214559
65MP0002229_neurodegeneration1.07978977
66MP0000920_abnormal_myelination1.07486563
67MP0004215_abnormal_myocardial_fiber1.06390659
68MP0003183_abnormal_peptide_metabolism1.05591052
69MP0001905_abnormal_dopamine_level1.04911794
70MP0001963_abnormal_hearing_physiology1.02387925
71MP0003137_abnormal_impulse_conducting1.01257050
72MP0004742_abnormal_vestibular_system1.00856080
73MP0005167_abnormal_blood-brain_barrier1.00736744
74MP0008872_abnormal_physiological_respon0.98995790
75MP0009384_cardiac_valve_regurgitation0.98311272
76MP0005253_abnormal_eye_physiology0.97612128
77MP0003123_paternal_imprinting0.91344547
78MP0003011_delayed_dark_adaptation0.91120465
79MP0003136_yellow_coat_color0.90837803
80MP0006072_abnormal_retinal_apoptosis0.87917615
81MP0004084_abnormal_cardiac_muscle0.86768546
82MP0004147_increased_porphyrin_level0.86218605
83MP0004145_abnormal_muscle_electrophysio0.85821268
84MP0000566_synostosis0.84667427
85MP0006276_abnormal_autonomic_nervous0.84147089
86MP0003879_abnormal_hair_cell0.83713498
87MP0002089_abnormal_postnatal_growth/wei0.81286992
88MP0005499_abnormal_olfactory_system0.81091879
89MP0005394_taste/olfaction_phenotype0.81091879
90MP0005620_abnormal_muscle_contractility0.80560978
91MP0004043_abnormal_pH_regulation0.80191067
92MP0003172_abnormal_lysosome_physiology0.78593359
93MP0002069_abnormal_eating/drinking_beha0.78048172
94MP0001177_atelectasis0.76410117
95MP0002752_abnormal_somatic_nervous0.76209625
96MP0000751_myopathy0.75426413
97MP0005623_abnormal_meninges_morphology0.75172011
98MP0005410_abnormal_fertilization0.74935079
99MP0001986_abnormal_taste_sensitivity0.74513255
100MP0000003_abnormal_adipose_tissue0.74365769
101MP0003279_aneurysm0.74351999
102MP0000026_abnormal_inner_ear0.73496773
103MP0008877_abnormal_DNA_methylation0.72797591
104MP0001853_heart_inflammation0.71210339
105MP0000013_abnormal_adipose_tissue0.70765525
106MP0001299_abnormal_eye_distance/0.70569864
107MP0005535_abnormal_body_temperature0.70346716
108MP0001529_abnormal_vocalization0.69562284
109MP0008874_decreased_physiological_sensi0.68818946
110MP0001188_hyperpigmentation0.68403877
111MP0000358_abnormal_cell_content/0.67887761
112MP0000631_abnormal_neuroendocrine_gland0.64160984
113MP0005171_absent_coat_pigmentation0.63940056
114MP0004085_abnormal_heartbeat0.60285551
115MP0005595_abnormal_vascular_smooth0.59443976
116MP0005166_decreased_susceptibility_to0.58986221
117MP0002653_abnormal_ependyma_morphology0.58723325
118MP0009840_abnormal_foam_cell0.57100316
119MP0003956_abnormal_body_size0.52098791
120MP0001765_abnormal_ion_homeostasis0.49655991
121MP0002083_premature_death0.47173676
122MP0010769_abnormal_survival0.46552347
123MP0002082_postnatal_lethality0.45347245
124MP0010770_preweaning_lethality0.45347245
125MP0003868_abnormal_feces_composition0.44908538
126MP0009379_abnormal_foot_pigmentation0.44866657
127MP0010768_mortality/aging0.44796053

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)5.88823784
2Aplasia of the phalanges of the hand (HP:0009802)5.88823784
3Aplasia involving bones of the extremities (HP:0009825)5.88823784
4Focal motor seizures (HP:0011153)5.71426667
5Megalencephaly (HP:0001355)5.41824897
6Myokymia (HP:0002411)5.38914059
7Horizontal nystagmus (HP:0000666)5.27926001
8Progressive cerebellar ataxia (HP:0002073)4.62106025
9Action tremor (HP:0002345)4.53388949
10Hemiplegia (HP:0002301)4.43804348
11Hemiparesis (HP:0001269)4.37652616
12Abnormality of binocular vision (HP:0011514)4.36864580
13Diplopia (HP:0000651)4.36864580
14Neurofibrillary tangles (HP:0002185)4.33425659
15Epileptic encephalopathy (HP:0200134)4.28208188
16Focal seizures (HP:0007359)4.19946030
17Visual hallucinations (HP:0002367)4.08091563
18Supranuclear gaze palsy (HP:0000605)3.75894766
19Dysdiadochokinesis (HP:0002075)3.63864577
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.52787162
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.52787162
22Cerebral inclusion bodies (HP:0100314)3.30351925
23Febrile seizures (HP:0002373)3.29367404
24Atonic seizures (HP:0010819)3.25125711
25Generalized tonic-clonic seizures (HP:0002069)3.22037541
26Status epilepticus (HP:0002133)3.19591859
27Abnormality of the corticospinal tract (HP:0002492)3.15901828
28Truncal ataxia (HP:0002078)3.12859855
29Postural instability (HP:0002172)3.12017434
30Abnormal eating behavior (HP:0100738)2.98651912
31Absence seizures (HP:0002121)2.97571781
32Clumsiness (HP:0002312)2.97421161
33Dysmetria (HP:0001310)2.94944752
34Intention tremor (HP:0002080)2.90671255
35Gaze-evoked nystagmus (HP:0000640)2.89222538
36Depression (HP:0000716)2.85806222
37Scanning speech (HP:0002168)2.76991897
38Dialeptic seizures (HP:0011146)2.74706887
39Anxiety (HP:0000739)2.72831232
40Acute necrotizing encephalopathy (HP:0006965)2.66734300
41Impaired smooth pursuit (HP:0007772)2.48887158
42Ankle clonus (HP:0011448)2.48406197
43Progressive macrocephaly (HP:0004481)2.48188789
44Hypoplastic left heart (HP:0004383)2.47675421
45Abnormal mitochondria in muscle tissue (HP:0008316)2.47534645
46Abnormality of the axillary hair (HP:0100134)2.47325681
47Abnormality of secondary sexual hair (HP:0009888)2.47325681
48Hyperventilation (HP:0002883)2.45078676
49Split foot (HP:0001839)2.43997654
50Narrow nasal bridge (HP:0000446)2.42986637
51Broad-based gait (HP:0002136)2.42279111
52Mixed hearing impairment (HP:0000410)2.40772959
53Tetraplegia (HP:0002445)2.39463687
54Genetic anticipation (HP:0003743)2.39309930
55Abnormality of ocular smooth pursuit (HP:0000617)2.38752609
56Abnormality of glycolysis (HP:0004366)2.33960590
57Increased serum pyruvate (HP:0003542)2.29744373
58Limb ataxia (HP:0002070)2.26463876
59Amblyopia (HP:0000646)2.23223356
60Humeroradial synostosis (HP:0003041)2.20305433
61Synostosis involving the elbow (HP:0003938)2.20305433
62Slow progression (HP:0003677)2.19707377
63Bradykinesia (HP:0002067)2.19558964
64Impaired vibration sensation in the lower limbs (HP:0002166)2.17650937
65Poor eye contact (HP:0000817)2.17571651
66Rigidity (HP:0002063)2.15140354
67Autoamputation (HP:0001218)2.15092127
68Dysmetric saccades (HP:0000641)2.14002550
69Abnormality of saccadic eye movements (HP:0000570)2.12751021
70Abnormality of the middle phalanges of the toes (HP:0010183)2.12276150
71Cerebellar atrophy (HP:0001272)2.11705845
72Long nose (HP:0003189)2.11302805
73Acute encephalopathy (HP:0006846)2.09890338
74Impaired social interactions (HP:0000735)2.08649919
75Abnormal social behavior (HP:0012433)2.08649919
76Confusion (HP:0001289)2.05873700
77Pheochromocytoma (HP:0002666)2.04522523
78Insidious onset (HP:0003587)2.03575432
79Termporal pattern (HP:0011008)2.03575432
80Urinary urgency (HP:0000012)2.02441630
81Back pain (HP:0003418)2.01293402
82Polyphagia (HP:0002591)1.99787849
83Stereotypic behavior (HP:0000733)1.99655792
84Annular pancreas (HP:0001734)1.99318730
85Hyperlipoproteinemia (HP:0010980)1.97183287
86Dysarthria (HP:0001260)1.96808193
87Gait ataxia (HP:0002066)1.96607043
88Postural tremor (HP:0002174)1.94508223
89Short hallux (HP:0010109)1.93412179
90Bronchomalacia (HP:0002780)1.92433761
91Spastic gait (HP:0002064)1.91476117
92Abnormality of the dental pulp (HP:0006479)1.89280598
93Mitochondrial inheritance (HP:0001427)1.89269521
94Pseudobulbar signs (HP:0002200)1.89227758
95Urinary bladder sphincter dysfunction (HP:0002839)1.88744332
96Psychosis (HP:0000709)1.86298508
97EEG with generalized epileptiform discharges (HP:0011198)1.86234207
98Lower limb muscle weakness (HP:0007340)1.86041513
99Morphological abnormality of the pyramidal tract (HP:0002062)1.85669349
100Spinal canal stenosis (HP:0003416)1.84028898
101Epileptiform EEG discharges (HP:0011182)1.83741500
102Hypoplastic heart (HP:0001961)1.83583320
103Dementia (HP:0000726)1.82911596
104Hypsarrhythmia (HP:0002521)1.82013206
105Ventricular fibrillation (HP:0001663)1.81502276
106Severe global developmental delay (HP:0011344)1.81393224
107Aplasia/Hypoplasia of the hallux (HP:0008362)1.78415170
108Neuronal loss in central nervous system (HP:0002529)1.74815100
109Adactyly (HP:0009776)1.73740028
110Excessive salivation (HP:0003781)1.73337665
111Drooling (HP:0002307)1.73337665
112Torticollis (HP:0000473)1.73017663
113Impaired vibratory sensation (HP:0002495)1.72624280
114Incomplete penetrance (HP:0003829)1.71940644
115Athetosis (HP:0002305)1.71609209
116Heart block (HP:0012722)1.69817992
117Leukodystrophy (HP:0002415)1.68765336
118Limb dystonia (HP:0002451)1.67724943
119Neuroendocrine neoplasm (HP:0100634)1.66715739
120Generalized myoclonic seizures (HP:0002123)1.65383029
121Fibular aplasia (HP:0002990)1.63769121
122Focal dystonia (HP:0004373)1.63640459
123Mutism (HP:0002300)1.62954800
124Peripheral hypomyelination (HP:0007182)1.62651882
125Delusions (HP:0000746)1.62256114
126Cerebral hypomyelination (HP:0006808)1.61897929
127Heterochromia iridis (HP:0001100)1.60372546
128Sleep apnea (HP:0010535)1.55118918
129Esotropia (HP:0000565)1.52694816
130Cerebral edema (HP:0002181)1.52590953
131Abnormal gallbladder physiology (HP:0012438)1.50065459
132Cholecystitis (HP:0001082)1.50065459
133Syncope (HP:0001279)1.49108782
134Increased hepatocellular lipid droplets (HP:0006565)1.48681385
135Craniofacial dystonia (HP:0012179)1.46452797
136Degeneration of anterior horn cells (HP:0002398)1.46369228
137Abnormality of the anterior horn cell (HP:0006802)1.46369228
138Unsteady gait (HP:0002317)1.42378968
139Increased CSF lactate (HP:0002490)1.41420099
140Akinesia (HP:0002304)1.37520524
141Epidermoid cyst (HP:0200040)1.36029241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.34925377
2LMTK23.58978273
3NTRK33.53587231
4NTRK23.21302379
5PRKD32.94148071
6PHKG12.66842886
7PHKG22.66842886
8MAP3K92.58885550
9TNIK2.34213292
10MAP3K42.22796560
11MINK12.21362781
12MAP2K72.04094884
13CAMKK11.99244320
14MUSK1.99191763
15CASK1.97569655
16CSNK1G21.86372734
17TRIB31.82216095
18PAK61.77277282
19MARK11.77177410
20CSNK1G31.68066307
21CSNK1A1L1.67032809
22CAMKK21.66466724
23PINK11.64961611
24STK381.64883967
25SGK21.63212189
26SGK4941.59762287
27SGK2231.59762287
28MYLK1.58334249
29TTK1.57523537
30DAPK21.55099397
31PRPF4B1.49385123
32SGK31.41077062
33PRKCG1.39975617
34NTRK11.38226112
35PRKG21.37170534
36CDK51.36017174
37MAPK131.34354289
38KSR21.33130395
39MAP2K41.32619731
40RIPK11.25732852
41TYRO31.25337108
42TESK11.23700500
43CSNK1G11.23681165
44BRAF1.17323099
45MAP3K131.17009057
46CDK191.09846178
47RIPK41.06701639
48PTK61.02900978
49GRK51.00705398
50PRKCH1.00308566
51LATS20.99914753
52FES0.95814978
53LIMK10.93743561
54MAPK120.92377173
55WNK10.92123417
56DYRK1A0.91742685
57TNK20.89801132
58NEK60.89287566
59CAMK2A0.87812128
60SIK10.87676790
61CAMK10.86883669
62PLK20.86243320
63CDK150.83693741
64RAF10.82550668
65CDK180.81783735
66DAPK30.80589041
67UHMK10.76077222
68KSR10.75741517
69SGK10.73027977
70CAMK1G0.72487626
71SIK20.72227116
72CDC42BPA0.71886982
73CDK140.71373387
74CDK11A0.71153283
75PRKCE0.69982793
76OXSR10.69406891
77CAMK2G0.67592001
78MAP3K20.66978162
79RET0.66091592
80MAP3K120.65724598
81STK110.65494975
82PAK40.64723315
83MAPK70.63227909
84PAK30.62727049
85CSNK1A10.61392129
86PDPK10.61149213
87SCYL20.60525072
88PDK10.60194023
89ADRBK10.59574573
90BMX0.58889624
91CAMK2B0.57591140
92MAP3K110.56617446
93ROCK20.56431996
94PRKDC0.55724206
95RPS6KA30.55351023
96FGR0.52363530
97ALK0.50186897
98ARAF0.49976301
99MOS0.48836688
100CCNB10.47948702
101CAMK40.47104530
102TSSK60.46765276
103DAPK10.46256285
104MAPKAPK50.45877500
105PRKCA0.45693191
106CSNK1D0.45032167
107ROCK10.44824984
108CAMK2D0.44817600
109FGFR20.44323330
110PRKCB0.42230740
111MAP3K70.42182831
112DMPK0.41509996
113CSNK1E0.41010445
114PKN10.40842219
115MARK20.40493944
116PRKD20.40493696
117FYN0.40156661
118PRKACA0.40131778
119CDK30.38690843
120MAPK100.38150647
121PRKCZ0.37781915
122PNCK0.37234807
123PRKACG0.37176147
124MAP3K10.37088336
125PRKG10.36621391
126SRC0.35393190
127NEK10.35010084
128DDR20.34554426
129ILK0.31743221
130RPS6KB10.31573986

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.17213298
2Nicotine addiction_Homo sapiens_hsa050333.50870974
3Fatty acid biosynthesis_Homo sapiens_hsa000612.79799732
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.76675485
5Glutamatergic synapse_Homo sapiens_hsa047242.61468055
6GABAergic synapse_Homo sapiens_hsa047272.60646041
7Synaptic vesicle cycle_Homo sapiens_hsa047212.51064951
8Circadian entrainment_Homo sapiens_hsa047132.24642477
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24325116
10Morphine addiction_Homo sapiens_hsa050322.15082639
11Salivary secretion_Homo sapiens_hsa049702.12612156
12Long-term potentiation_Homo sapiens_hsa047202.04483724
13Olfactory transduction_Homo sapiens_hsa047402.04015545
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00653896
15Gastric acid secretion_Homo sapiens_hsa049711.92338566
16Insulin secretion_Homo sapiens_hsa049111.84401651
17Amphetamine addiction_Homo sapiens_hsa050311.72845931
18Alzheimers disease_Homo sapiens_hsa050101.60096392
19Oxidative phosphorylation_Homo sapiens_hsa001901.59707992
20Taste transduction_Homo sapiens_hsa047421.53660280
21Long-term depression_Homo sapiens_hsa047301.49828846
22Cocaine addiction_Homo sapiens_hsa050301.46426272
23Dopaminergic synapse_Homo sapiens_hsa047281.46014707
24Cholinergic synapse_Homo sapiens_hsa047251.41742959
25Parkinsons disease_Homo sapiens_hsa050121.37678737
26Calcium signaling pathway_Homo sapiens_hsa040201.37427761
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35945835
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33559141
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31750963
30Serotonergic synapse_Homo sapiens_hsa047261.19759127
31Renin secretion_Homo sapiens_hsa049241.19327336
32Circadian rhythm_Homo sapiens_hsa047101.18322770
33cAMP signaling pathway_Homo sapiens_hsa040241.14643802
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14514204
35Fatty acid metabolism_Homo sapiens_hsa012121.11300791
36Oxytocin signaling pathway_Homo sapiens_hsa049211.07210093
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03769965
38Gap junction_Homo sapiens_hsa045401.03645742
39Bile secretion_Homo sapiens_hsa049761.03597000
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02426258
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02187128
42Dorso-ventral axis formation_Homo sapiens_hsa043200.96511112
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96379257
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95279890
45Pancreatic secretion_Homo sapiens_hsa049720.95114098
46GnRH signaling pathway_Homo sapiens_hsa049120.94533082
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94004229
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92440477
49Huntingtons disease_Homo sapiens_hsa050160.92319738
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.91757172
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90982871
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89961529
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86786218
54Melanogenesis_Homo sapiens_hsa049160.81485783
55Thyroid hormone synthesis_Homo sapiens_hsa049180.78381814
56Cardiac muscle contraction_Homo sapiens_hsa042600.78012410
57Estrogen signaling pathway_Homo sapiens_hsa049150.77318731
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75805820
59Collecting duct acid secretion_Homo sapiens_hsa049660.74909098
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73861508
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73620118
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72698411
63Type II diabetes mellitus_Homo sapiens_hsa049300.68190303
64Mineral absorption_Homo sapiens_hsa049780.67781220
65Arginine biosynthesis_Homo sapiens_hsa002200.67673335
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65717002
67Butanoate metabolism_Homo sapiens_hsa006500.63720212
68Fatty acid degradation_Homo sapiens_hsa000710.63354986
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62367904
70Renin-angiotensin system_Homo sapiens_hsa046140.61754539
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61750319
72Glioma_Homo sapiens_hsa052140.60289250
73Pyruvate metabolism_Homo sapiens_hsa006200.58137800
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56708190
75Glucagon signaling pathway_Homo sapiens_hsa049220.56073754
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.55707111
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.54344251
78ErbB signaling pathway_Homo sapiens_hsa040120.54004760
79Choline metabolism in cancer_Homo sapiens_hsa052310.53543117
80Axon guidance_Homo sapiens_hsa043600.51374540
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.50669520
82African trypanosomiasis_Homo sapiens_hsa051430.50230371
83Dilated cardiomyopathy_Homo sapiens_hsa054140.48571884
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47812363
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46889489
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46622922
87PPAR signaling pathway_Homo sapiens_hsa033200.45425440
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.44038044
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43345081
90Glycerolipid metabolism_Homo sapiens_hsa005610.43036566
91MAPK signaling pathway_Homo sapiens_hsa040100.40543640
92Fatty acid elongation_Homo sapiens_hsa000620.40204148
93Vibrio cholerae infection_Homo sapiens_hsa051100.39493076
94Inositol phosphate metabolism_Homo sapiens_hsa005620.39235940
95Phototransduction_Homo sapiens_hsa047440.36920077
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36678705
97Rap1 signaling pathway_Homo sapiens_hsa040150.36367831
98Propanoate metabolism_Homo sapiens_hsa006400.36051049
99Type I diabetes mellitus_Homo sapiens_hsa049400.35797841
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35496072
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.33385200
102VEGF signaling pathway_Homo sapiens_hsa043700.32312822
103Sulfur metabolism_Homo sapiens_hsa009200.31626197
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31051290
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30768232
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29900572
107Alcoholism_Homo sapiens_hsa050340.29384734
108Ras signaling pathway_Homo sapiens_hsa040140.27160373
109Endocytosis_Homo sapiens_hsa041440.25619535
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25330223
111Steroid biosynthesis_Homo sapiens_hsa001000.24517132
112Oocyte meiosis_Homo sapiens_hsa041140.24198773
113mTOR signaling pathway_Homo sapiens_hsa041500.23316065
114Vitamin B6 metabolism_Homo sapiens_hsa007500.22061878
115Prion diseases_Homo sapiens_hsa050200.21951558
116* Carbon metabolism_Homo sapiens_hsa012000.17127782
117Arginine and proline metabolism_Homo sapiens_hsa003300.16244750
118Regulation of autophagy_Homo sapiens_hsa041400.14674387
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13976576
120Phenylalanine metabolism_Homo sapiens_hsa003600.12140180
121HIF-1 signaling pathway_Homo sapiens_hsa040660.07506420

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