ALG10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.54225058
2nuclear pore complex assembly (GO:0051292)6.43360178
3replication fork processing (GO:0031297)4.87684943
4pore complex assembly (GO:0046931)4.77447755
5DNA double-strand break processing (GO:0000729)4.74713900
6protein localization to kinetochore (GO:0034501)4.68083107
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.67625613
8sister chromatid segregation (GO:0000819)4.62486182
9telomere maintenance via semi-conservative replication (GO:0032201)4.52995761
10mitotic sister chromatid cohesion (GO:0007064)4.51418592
11CENP-A containing nucleosome assembly (GO:0034080)4.51416576
12mitotic recombination (GO:0006312)4.46845758
13chromatin remodeling at centromere (GO:0031055)4.37865920
14DNA strand elongation involved in DNA replication (GO:0006271)4.34951071
15negative regulation of DNA-dependent DNA replication (GO:2000104)4.33955421
16regulation of DNA endoreduplication (GO:0032875)4.33223442
17meiotic chromosome segregation (GO:0045132)4.32273257
18mitotic sister chromatid segregation (GO:0000070)4.26812376
19telomere maintenance via recombination (GO:0000722)4.24145342
20protein localization to chromosome, centromeric region (GO:0071459)4.21939352
21negative regulation of cell cycle G2/M phase transition (GO:1902750)4.21367112
22DNA strand elongation (GO:0022616)4.20381126
23microtubule depolymerization (GO:0007019)4.16726876
24protein K11-linked deubiquitination (GO:0035871)4.15530584
25spindle checkpoint (GO:0031577)4.14109778
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.13722347
27mitotic metaphase plate congression (GO:0007080)4.13682996
28regulation of centriole replication (GO:0046599)4.12679919
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.07262182
30mitotic nuclear envelope disassembly (GO:0007077)4.05207372
31nucleotide-excision repair, DNA gap filling (GO:0006297)4.03503983
32DNA unwinding involved in DNA replication (GO:0006268)3.97446235
33sphingosine metabolic process (GO:0006670)3.89610409
34mitotic chromosome condensation (GO:0007076)3.83531103
35mitotic spindle checkpoint (GO:0071174)3.82999567
36non-recombinational repair (GO:0000726)3.82615530
37double-strand break repair via nonhomologous end joining (GO:0006303)3.82615530
38kinetochore organization (GO:0051383)3.82128742
39regulation of centrosome cycle (GO:0046605)3.77951738
40histone exchange (GO:0043486)3.76841662
41metaphase plate congression (GO:0051310)3.71908543
42nuclear envelope disassembly (GO:0051081)3.70412655
43membrane disassembly (GO:0030397)3.70412655
44regulation of centrosome duplication (GO:0010824)3.69608130
45resolution of meiotic recombination intermediates (GO:0000712)3.67724789
46spindle assembly involved in mitosis (GO:0090307)3.62805073
47centriole replication (GO:0007099)3.62730080
48DNA replication initiation (GO:0006270)3.59304014
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.58975665
50negative regulation of chromosome segregation (GO:0051985)3.57621821
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55929805
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55929805
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55929805
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.55929805
55negative regulation of sister chromatid segregation (GO:0033046)3.55929805
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.54466537
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.54466537
58diol metabolic process (GO:0034311)3.53720380
59mitotic spindle assembly checkpoint (GO:0007094)3.51875710
60spindle assembly checkpoint (GO:0071173)3.48754645
61purine nucleobase biosynthetic process (GO:0009113)3.47716913
62regulation of chromosome segregation (GO:0051983)3.42562920
63DNA replication-independent nucleosome assembly (GO:0006336)3.42454093
64DNA replication-independent nucleosome organization (GO:0034724)3.42454093
65DNA replication checkpoint (GO:0000076)3.42386567
66regulation of mitotic sister chromatid separation (GO:0010965)3.41398441
67regulation of mitotic sister chromatid segregation (GO:0033047)3.41398441
68regulation of sister chromatid segregation (GO:0033045)3.41398441
69sphingoid metabolic process (GO:0046519)3.37465489
70spindle assembly (GO:0051225)3.33617394
71nucleobase biosynthetic process (GO:0046112)3.32916625
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.28701899
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28701899
74IMP biosynthetic process (GO:0006188)3.26348623
75telomere maintenance (GO:0000723)3.25296486
76DNA-dependent DNA replication (GO:0006261)3.21403389
77DNA topological change (GO:0006265)3.21032557
78double-strand break repair via homologous recombination (GO:0000724)3.20085913
79recombinational repair (GO:0000725)3.19985838
80telomere organization (GO:0032200)3.19482586
81telomere maintenance via telomere lengthening (GO:0010833)3.18001570
82DNA replication-dependent nucleosome organization (GO:0034723)3.15447519
83DNA replication-dependent nucleosome assembly (GO:0006335)3.15447519
84positive regulation of chromosome segregation (GO:0051984)3.15170799
85monoubiquitinated protein deubiquitination (GO:0035520)3.15005046
86IMP metabolic process (GO:0046040)3.14126855
87regulation of meiosis I (GO:0060631)3.13881287
88kinetochore assembly (GO:0051382)3.13679463
89DNA catabolic process, exonucleolytic (GO:0000738)3.13257180
90DNA strand renaturation (GO:0000733)3.12593019
91negative regulation of DNA recombination (GO:0045910)3.12386538
92microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.11866123
93establishment of chromosome localization (GO:0051303)3.11609141
94DNA synthesis involved in DNA repair (GO:0000731)3.10809513
95paraxial mesoderm development (GO:0048339)3.10556741
96regulation of helicase activity (GO:0051095)3.10416359
97ribosome assembly (GO:0042255)3.10307844
98regulation of DNA-dependent DNA replication (GO:0090329)3.10272596
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10054749
100chromosome segregation (GO:0007059)3.09820795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.12157503
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63488844
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.52251563
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.43076799
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14572498
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08420369
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74931464
8* IGF1R_20145208_ChIP-Seq_DFB_Human2.69776628
9AR_21909140_ChIP-Seq_LNCAP_Human2.69757329
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.66557745
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56258552
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27832289
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.26811754
14ELK1_19687146_ChIP-ChIP_HELA_Human2.20283176
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07784923
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99969187
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.97987432
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96034071
19PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96011189
20FUS_26573619_Chip-Seq_HEK293_Human1.92962032
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.92192479
22EWS_26573619_Chip-Seq_HEK293_Human1.86211802
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86022852
24GBX2_23144817_ChIP-Seq_PC3_Human1.85368938
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.81443268
26* AR_21572438_ChIP-Seq_LNCaP_Human1.79697332
27TAF15_26573619_Chip-Seq_HEK293_Human1.69299363
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68875246
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68860029
30DCP1A_22483619_ChIP-Seq_HELA_Human1.67311263
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63572300
32* VDR_23849224_ChIP-Seq_CD4+_Human1.57531243
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56654400
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55800735
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.53785676
36* ER_23166858_ChIP-Seq_MCF-7_Human1.50083670
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48479002
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45615920
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.41330417
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.38588737
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26488613
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24768373
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24494804
44P300_19829295_ChIP-Seq_ESCs_Human1.23953530
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22456867
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19405965
47* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19350065
48VDR_22108803_ChIP-Seq_LS180_Human1.17276639
49IRF1_19129219_ChIP-ChIP_H3396_Human1.17137009
50MYC_18940864_ChIP-ChIP_HL60_Human1.17082575
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16013183
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15293283
53* ETS1_20019798_ChIP-Seq_JURKAT_Human1.13848813
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13263259
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13175038
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10791511
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.09815373
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09491419
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07652810
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07033428
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02981467
62* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02772330
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01364412
64* ZNF274_21170338_ChIP-Seq_K562_Hela1.00173077
65FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98255695
66KDM5A_27292631_Chip-Seq_BREAST_Human0.97202040
67MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96098433
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95444780
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95090744
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94913598
71POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94725871
72SOX2_16153702_ChIP-ChIP_HESCs_Human0.92324737
73SALL4_22934838_ChIP-ChIP_CD34+_Human0.91814276
74MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91586026
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91538648
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91299401
77SRF_21415370_ChIP-Seq_HL-1_Mouse0.90863594
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.90518579
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89457425
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88889660
81* STAT3_23295773_ChIP-Seq_U87_Human0.88503638
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87789877
83SMAD4_21799915_ChIP-Seq_A2780_Human0.87492777
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87408134
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87068129
86* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86147349
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84386140
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.83727453
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82840261
90TTF2_22483619_ChIP-Seq_HELA_Human0.82373443
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82310629
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82134423
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81351570
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.81039542
95SOX9_26525672_Chip-Seq_HEART_Mouse0.79652817
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.79425528
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78474979
98GABP_19822575_ChIP-Seq_HepG2_Human0.78432390
99TCF4_23295773_ChIP-Seq_U87_Human0.78127992
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.74375263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.75393041
2MP0008057_abnormal_DNA_replication4.65600494
3MP0008058_abnormal_DNA_repair3.72581104
4MP0003111_abnormal_nucleus_morphology3.38651088
5MP0003890_abnormal_embryonic-extraembry3.35811268
6MP0003077_abnormal_cell_cycle3.28928598
7MP0004957_abnormal_blastocyst_morpholog3.28063150
8MP0009697_abnormal_copulation3.27191486
9MP0003693_abnormal_embryo_hatching3.13775882
10MP0002009_preneoplasia3.12467657
11MP0010352_gastrointestinal_tract_polyps2.85954934
12MP0000569_abnormal_digit_pigmentation2.84640942
13MP0003136_yellow_coat_color2.84231285
14MP0002837_dystrophic_cardiac_calcinosis2.64380300
15MP0005171_absent_coat_pigmentation2.45657503
16MP0008932_abnormal_embryonic_tissue2.25077997
17MP0008007_abnormal_cellular_replicative2.08732985
18MP0003718_maternal_effect1.93565202
19MP0003806_abnormal_nucleotide_metabolis1.78312005
20MP0010307_abnormal_tumor_latency1.77382335
21MP0003315_abnormal_perineum_morphology1.71719174
22MP0002396_abnormal_hematopoietic_system1.71019756
23MP0002102_abnormal_ear_morphology1.64985879
24MP0002938_white_spotting1.55717773
25MP0004147_increased_porphyrin_level1.49064926
26MP0001697_abnormal_embryo_size1.47367940
27MP0000383_abnormal_hair_follicle1.47040541
28MP0001672_abnormal_embryogenesis/_devel1.44658230
29MP0005380_embryogenesis_phenotype1.44658230
30MP0005187_abnormal_penis_morphology1.35902982
31MP0000350_abnormal_cell_proliferation1.35279066
32MP0001730_embryonic_growth_arrest1.32454439
33MP0003045_fibrosis1.31973868
34MP0006035_abnormal_mitochondrial_morpho1.30517932
35MP0003937_abnormal_limbs/digits/tail_de1.27331195
36MP0005395_other_phenotype1.25073419
37MP0003984_embryonic_growth_retardation1.24486103
38MP0002084_abnormal_developmental_patter1.20658004
39MP0002088_abnormal_embryonic_growth/wei1.19207005
40MP0010678_abnormal_skin_adnexa1.18322037
41MP0003941_abnormal_skin_development1.17544275
42MP0002210_abnormal_sex_determination1.15467986
43MP0002160_abnormal_reproductive_system1.13798950
44MP0005647_abnormal_sex_gland1.12798706
45MP0004233_abnormal_muscle_weight1.11724347
46MP0003656_abnormal_erythrocyte_physiolo1.11564483
47MP0002085_abnormal_embryonic_tissue1.10417726
48MP0002086_abnormal_extraembryonic_tissu1.09182070
49MP0005075_abnormal_melanosome_morpholog1.07605310
50MP0003221_abnormal_cardiomyocyte_apopto1.06995344
51MP0002080_prenatal_lethality1.06533224
52MP0004808_abnormal_hematopoietic_stem1.05932242
53MP0001929_abnormal_gametogenesis1.05873414
54MP0000015_abnormal_ear_pigmentation1.04980563
55MP0001286_abnormal_eye_development1.01378498
56MP0003786_premature_aging0.98542489
57MP0001145_abnormal_male_reproductive0.96677773
58MP0004197_abnormal_fetal_growth/weight/0.96238961
59MP0000358_abnormal_cell_content/0.94166679
60MP0001293_anophthalmia0.92220806
61MP0006072_abnormal_retinal_apoptosis0.90906487
62MP0000653_abnormal_sex_gland0.90713316
63MP0000313_abnormal_cell_death0.90626546
64MP0001529_abnormal_vocalization0.88490018
65MP0002006_tumorigenesis0.87625657
66MP0002095_abnormal_skin_pigmentation0.86073246
67MP0005310_abnormal_salivary_gland0.85939869
68MP0000490_abnormal_crypts_of0.85775310
69MP0002138_abnormal_hepatobiliary_system0.84240223
70MP0003698_abnormal_male_reproductive0.82028778
71MP0002019_abnormal_tumor_incidence0.81378765
72MP0006054_spinal_hemorrhage0.80943942
73MP0001764_abnormal_homeostasis0.80405942
74MP0001119_abnormal_female_reproductive0.80292540
75MP0005253_abnormal_eye_physiology0.80194384
76MP0002168_other_aberrant_phenotype0.80126771
77MP0002269_muscular_atrophy0.79862325
78MP0002075_abnormal_coat/hair_pigmentati0.79152398
79MP0002090_abnormal_vision0.78790404
80MP0003567_abnormal_fetal_cardiomyocyte0.77395382
81MP0002653_abnormal_ependyma_morphology0.76576608
82MP0002697_abnormal_eye_size0.76260921
83MP0009703_decreased_birth_body0.75137870
84MP0001324_abnormal_eye_pigmentation0.73654107
85MP0003763_abnormal_thymus_physiology0.72965448
86MP0005389_reproductive_system_phenotype0.72175403
87MP0000427_abnormal_hair_cycle0.71862149
88MP0003943_abnormal_hepatobiliary_system0.71611846
89MP0004381_abnormal_hair_follicle0.71047394
90MP0001661_extended_life_span0.69472678
91MP0000537_abnormal_urethra_morphology0.68384316
92MP0005391_vision/eye_phenotype0.68161468
93MP0002233_abnormal_nose_morphology0.67918088
94MP0005367_renal/urinary_system_phenotyp0.67846436
95MP0000516_abnormal_urinary_system0.67846436
96MP0002877_abnormal_melanocyte_morpholog0.67544717
97MP0005410_abnormal_fertilization0.66352531
98MP0006036_abnormal_mitochondrial_physio0.65685741
99MP0003935_abnormal_craniofacial_develop0.63510429
100MP0002092_abnormal_eye_morphology0.61340586

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.26160640
2Chromsome breakage (HP:0040012)5.78499297
3Aplasia/Hypoplasia of the uvula (HP:0010293)4.94188955
4Abnormality of chromosome stability (HP:0003220)4.33318511
5Neoplasm of the adrenal cortex (HP:0100641)4.20474168
6Colon cancer (HP:0003003)3.95114263
7Abnormality of the preputium (HP:0100587)3.81229828
8Meckel diverticulum (HP:0002245)3.74532753
9Abnormality of the ileum (HP:0001549)3.68725938
10Glioma (HP:0009733)3.40453207
11Volvulus (HP:0002580)3.35816250
12IgM deficiency (HP:0002850)3.32341793
13Small intestinal stenosis (HP:0012848)3.17466555
14Duodenal stenosis (HP:0100867)3.17466555
15Acanthocytosis (HP:0001927)3.17352626
16Nephroblastoma (Wilms tumor) (HP:0002667)3.15514359
17Medulloblastoma (HP:0002885)3.13692754
18Embryonal renal neoplasm (HP:0011794)3.06406895
19Neoplasm of the colon (HP:0100273)3.03190032
20Clubbing of toes (HP:0100760)3.01321738
21Birth length less than 3rd percentile (HP:0003561)2.99901882
22Myelodysplasia (HP:0002863)2.89813952
23Neoplasm of the small intestine (HP:0100833)2.77980342
24Sloping forehead (HP:0000340)2.73049446
25Abnormal lung lobation (HP:0002101)2.66865884
26Abnormality of the duodenum (HP:0002246)2.62542240
27Astrocytoma (HP:0009592)2.60895794
28Abnormality of the astrocytes (HP:0100707)2.60895794
29Ependymoma (HP:0002888)2.57440354
30Aplastic anemia (HP:0001915)2.51548628
31Abnormality of the carotid arteries (HP:0005344)2.49487106
32Absent radius (HP:0003974)2.48692093
33Neoplasm of the adrenal gland (HP:0100631)2.43985667
34Biliary tract neoplasm (HP:0100574)2.42072078
35Cortical dysplasia (HP:0002539)2.41101327
36Ectopic kidney (HP:0000086)2.38881581
37Dyschromatopsia (HP:0007641)2.37686356
38Absent forearm bone (HP:0003953)2.35716812
39Aplasia involving forearm bones (HP:0009822)2.35716812
40Rhabdomyosarcoma (HP:0002859)2.35427706
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.35133588
42Absent/shortened dynein arms (HP:0200106)2.35133588
43Poor head control (HP:0002421)2.33920337
44Cafe-au-lait spot (HP:0000957)2.24106421
45Gonadotropin excess (HP:0000837)2.18564481
46Tubulointerstitial nephritis (HP:0001970)2.13925989
47Bone marrow hypocellularity (HP:0005528)2.10645455
48Neoplasm of the pancreas (HP:0002894)2.09581069
49Abnormality of lateral ventricle (HP:0030047)2.09419701
50Pancreatic islet-cell hyperplasia (HP:0004510)2.07622295
51Amelogenesis imperfecta (HP:0000705)2.06816481
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.06290033
53Arteriovenous malformation (HP:0100026)2.06162421
54Embryonal neoplasm (HP:0002898)2.05751435
55Poikilocytosis (HP:0004447)2.05182593
56Duplicated collecting system (HP:0000081)2.04924038
57Lower limb hyperreflexia (HP:0002395)2.03683726
58Triphalangeal thumb (HP:0001199)2.00555476
59Abnormal hair whorl (HP:0010721)1.99191267
60Pancreatic cysts (HP:0001737)1.96140392
61Malignant gastrointestinal tract tumors (HP:0006749)1.94425442
62Gastrointestinal carcinoma (HP:0002672)1.94425442
63Capillary hemangiomas (HP:0005306)1.92357947
64Breast carcinoma (HP:0003002)1.92232735
65Papillary thyroid carcinoma (HP:0002895)1.90887942
66IgA deficiency (HP:0002720)1.90806824
67Ovarian neoplasm (HP:0100615)1.86859894
68Poikiloderma (HP:0001029)1.86262472
69Cerebellar dysplasia (HP:0007033)1.85065402
70Choanal atresia (HP:0000453)1.84980052
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84284316
72Abnormal biliary tract morphology (HP:0012440)1.82787571
73Prominent nose (HP:0000448)1.81496063
74Selective tooth agenesis (HP:0001592)1.81080211
75Abnormal ciliary motility (HP:0012262)1.77754756
76Abnormality of methionine metabolism (HP:0010901)1.74461796
77Abnormality of the renal collecting system (HP:0004742)1.73596917
78Gonadal dysgenesis (HP:0000133)1.72104698
79Hematochezia (HP:0002573)1.72041436
80Tinnitus (HP:0000360)1.71618153
81Overlapping toe (HP:0001845)1.70438395
82Increased nuchal translucency (HP:0010880)1.69779605
83Abnormality of chromosome segregation (HP:0002916)1.69458663
84Horizontal nystagmus (HP:0000666)1.69204483
85Acute myeloid leukemia (HP:0004808)1.68905475
86Pancytopenia (HP:0001876)1.68738736
87Agnosia (HP:0010524)1.66172757
88Neoplasm of the rectum (HP:0100743)1.65235047
89Increased mean platelet volume (HP:0011877)1.65087057
90Recurrent sinusitis (HP:0011108)1.64619132
91Neoplasm of the oral cavity (HP:0100649)1.63106225
92Abnormal spermatogenesis (HP:0008669)1.62594207
93Type I transferrin isoform profile (HP:0003642)1.59531111
94Enlarged kidneys (HP:0000105)1.59050375
95Chronic hepatic failure (HP:0100626)1.59012217
96Meningioma (HP:0002858)1.58501208
97Bony spicule pigmentary retinopathy (HP:0007737)1.58073245
98Oligohydramnios (HP:0001562)1.56770142
99Proximal amyotrophy (HP:0007126)1.56443204
100Abnormal glycosylation (HP:0012345)1.56140553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.02386724
2ZAK5.80766543
3STK38L3.31178098
4TTK2.96671527
5EIF2AK32.85062491
6WEE12.66075982
7CDC72.65757384
8FRK2.63950148
9BUB12.31027221
10NEK12.10192090
11SRPK12.08707832
12EIF2AK12.08618066
13NUAK12.07024959
14MKNK22.02904155
15STK31.92410246
16LATS21.90213343
17BRSK21.88298996
18MKNK11.88286741
19PLK41.86523136
20BMPR1B1.84519795
21PLK31.79789487
22WNK31.77583922
23ACVR1B1.71157206
24NEK21.60735561
25PBK1.57726178
26PLK11.54296929
27VRK11.53651594
28CHEK21.46625750
29TRIM281.44378739
30MELK1.43903981
31TAF11.34984957
32TSSK61.32880587
33ATR1.30620528
34MAP3K101.30265917
35TNIK1.22871545
36EIF2AK21.18415117
37NLK1.16082738
38MST41.14190058
39CSNK1A1L1.11322637
40TLK11.09696279
41ATM0.93094233
42AURKB0.89276064
43STK160.88175386
44YES10.87975494
45ERBB30.84763447
46CDK120.82987420
47BRD40.79351719
48PLK20.72696207
49CDK70.71849473
50TGFBR10.71283309
51STK40.71185245
52CDK30.69515763
53CSNK1G10.69478714
54STK380.68963912
55CSNK1G30.68671925
56CHEK10.68099390
57MARK30.64145836
58CSNK1G20.63456618
59CDK60.53785283
60RPS6KB20.53761334
61CCNB10.52675993
62STK390.52528838
63PIM10.52332094
64BRSK10.51416218
65PINK10.50224552
66SCYL20.49526344
67STK100.46987116
68RPS6KA40.46087448
69MAP2K70.44962538
70MAP3K40.43914815
71MST1R0.43282497
72CDK10.41985881
73DYRK30.41961835
74CDK40.39354743
75BCR0.38714480
76MAP3K80.38296768
77NEK60.37743455
78CSNK1D0.35140161
79AURKA0.33830714
80RPS6KA50.33789591
81CDK20.32660516
82RPS6KB10.31412843
83AKT20.30846895
84EEF2K0.30544663
85CSNK2A10.28480424
86CLK10.27537152
87PRKDC0.26273239
88PRKAA20.25243467
89MAP3K20.24674166
90NEK90.22744649
91TEC0.22525916
92CASK0.22085638
93MAP4K20.21019878
94MAPK130.20055176
95CDK80.19530725
96OXSR10.17985125
97CSNK2A20.17815823
98CSNK1E0.17752607
99CAMKK20.16502227
100PNCK0.16022386

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.58646592
2DNA replication_Homo sapiens_hsa030304.36744227
3Homologous recombination_Homo sapiens_hsa034403.82907189
4Non-homologous end-joining_Homo sapiens_hsa034503.67664608
5Fanconi anemia pathway_Homo sapiens_hsa034603.67250179
6Cell cycle_Homo sapiens_hsa041103.34743328
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16503751
8Nucleotide excision repair_Homo sapiens_hsa034202.60616643
9Base excision repair_Homo sapiens_hsa034102.57932228
10RNA transport_Homo sapiens_hsa030132.57885198
11One carbon pool by folate_Homo sapiens_hsa006702.56146986
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33344789
13Basal transcription factors_Homo sapiens_hsa030222.30951149
14Systemic lupus erythematosus_Homo sapiens_hsa053222.25002311
15Spliceosome_Homo sapiens_hsa030402.06750914
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80726291
17Proteasome_Homo sapiens_hsa030501.73129942
18p53 signaling pathway_Homo sapiens_hsa041151.71670435
19RNA degradation_Homo sapiens_hsa030181.66171887
20Alcoholism_Homo sapiens_hsa050341.56702561
21Pyrimidine metabolism_Homo sapiens_hsa002401.52719359
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47681490
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.46627629
24Phototransduction_Homo sapiens_hsa047441.42125177
25Oocyte meiosis_Homo sapiens_hsa041141.32288490
26Selenocompound metabolism_Homo sapiens_hsa004501.30757207
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24188399
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17771558
29Viral carcinogenesis_Homo sapiens_hsa052031.12250105
30Sphingolipid metabolism_Homo sapiens_hsa006001.08423159
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08090118
32Propanoate metabolism_Homo sapiens_hsa006401.07286651
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07114282
34TGF-beta signaling pathway_Homo sapiens_hsa043501.06861394
35Purine metabolism_Homo sapiens_hsa002301.06257243
36RNA polymerase_Homo sapiens_hsa030201.04851873
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03305520
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01563950
39Protein export_Homo sapiens_hsa030600.98487439
40Pyruvate metabolism_Homo sapiens_hsa006200.93191287
41mRNA surveillance pathway_Homo sapiens_hsa030150.93180167
42* N-Glycan biosynthesis_Homo sapiens_hsa005100.92181856
43Glutathione metabolism_Homo sapiens_hsa004800.88359668
44Steroid biosynthesis_Homo sapiens_hsa001000.83721750
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.75221927
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70506783
47Lysine degradation_Homo sapiens_hsa003100.68894008
48Thyroid cancer_Homo sapiens_hsa052160.67855622
49Colorectal cancer_Homo sapiens_hsa052100.67266633
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66778120
51Nitrogen metabolism_Homo sapiens_hsa009100.63805417
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.63344656
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62931087
54Adherens junction_Homo sapiens_hsa045200.61484349
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61400908
56MicroRNAs in cancer_Homo sapiens_hsa052060.58061088
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54035058
58Butanoate metabolism_Homo sapiens_hsa006500.53184951
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52947897
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50145072
61Fatty acid elongation_Homo sapiens_hsa000620.48261449
62Olfactory transduction_Homo sapiens_hsa047400.48179497
63Biosynthesis of amino acids_Homo sapiens_hsa012300.44508266
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42984336
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42868656
66Taste transduction_Homo sapiens_hsa047420.40864984
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39949047
68Epstein-Barr virus infection_Homo sapiens_hsa051690.39472030
69HTLV-I infection_Homo sapiens_hsa051660.39127731
70Herpes simplex infection_Homo sapiens_hsa051680.38466219
71Dorso-ventral axis formation_Homo sapiens_hsa043200.37561796
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.36804237
73Hippo signaling pathway_Homo sapiens_hsa043900.36428526
74Tryptophan metabolism_Homo sapiens_hsa003800.36120412
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35895801
76Hedgehog signaling pathway_Homo sapiens_hsa043400.35877485
77Wnt signaling pathway_Homo sapiens_hsa043100.34490813
78* Metabolic pathways_Homo sapiens_hsa011000.32865348
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32594202
80Basal cell carcinoma_Homo sapiens_hsa052170.32079209
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30538574
82Prostate cancer_Homo sapiens_hsa052150.30051993
83Melanoma_Homo sapiens_hsa052180.28726508
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26630464
85Small cell lung cancer_Homo sapiens_hsa052220.26575482
86Glycerolipid metabolism_Homo sapiens_hsa005610.26060722
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25864229
88Pancreatic cancer_Homo sapiens_hsa052120.23474950
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22262899
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22137282
91Chronic myeloid leukemia_Homo sapiens_hsa052200.22069447
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19486261
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18874873
94Nicotine addiction_Homo sapiens_hsa050330.18433260
95Peroxisome_Homo sapiens_hsa041460.17279523
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17186076
97Fatty acid degradation_Homo sapiens_hsa000710.16634497
98Circadian rhythm_Homo sapiens_hsa047100.13212174
99Fatty acid metabolism_Homo sapiens_hsa012120.11254249
100Regulation of autophagy_Homo sapiens_hsa041400.10563580

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