ALG10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.74522790
2nuclear pore complex assembly (GO:0051292)4.48558416
3mitotic sister chromatid cohesion (GO:0007064)4.31348259
4prenylation (GO:0097354)4.29023070
5protein prenylation (GO:0018342)4.29023070
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.24604940
7neural tube formation (GO:0001841)4.21398615
8DNA unwinding involved in DNA replication (GO:0006268)4.10191771
9nuclear pore organization (GO:0006999)4.08575869
10hippo signaling (GO:0035329)3.96209898
11replication fork processing (GO:0031297)3.89027331
12regulation of DNA endoreduplication (GO:0032875)3.79651617
13regulation of RNA export from nucleus (GO:0046831)3.70865567
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.66802470
15glucocorticoid receptor signaling pathway (GO:0042921)3.66370760
16mitotic chromosome condensation (GO:0007076)3.65863529
17meiotic chromosome segregation (GO:0045132)3.63854169
18pre-miRNA processing (GO:0031054)3.62556883
19recombinational repair (GO:0000725)3.61772212
20double-strand break repair via homologous recombination (GO:0000724)3.60472504
21protein localization to kinetochore (GO:0034501)3.60385864
22centriole replication (GO:0007099)3.59885327
23protein K11-linked deubiquitination (GO:0035871)3.58587173
24cytoplasmic mRNA processing body assembly (GO:0033962)3.56223111
25regulation of centriole replication (GO:0046599)3.51867841
26Golgi transport vesicle coating (GO:0048200)3.49251894
27COPI coating of Golgi vesicle (GO:0048205)3.49251894
28reciprocal DNA recombination (GO:0035825)3.45786378
29reciprocal meiotic recombination (GO:0007131)3.45786378
30peptidyl-lysine dimethylation (GO:0018027)3.45284240
31regulation of sister chromatid cohesion (GO:0007063)3.44228387
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44087962
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.44087962
34regulation of translation, ncRNA-mediated (GO:0045974)3.44087962
35regulation of translational fidelity (GO:0006450)3.43694609
36NLS-bearing protein import into nucleus (GO:0006607)3.41554059
37regulation of centrosome duplication (GO:0010824)3.30031918
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.28217517
39heterochromatin organization (GO:0070828)3.26696611
40response to pheromone (GO:0019236)3.21338719
41dosage compensation (GO:0007549)3.16974364
42signal peptide processing (GO:0006465)3.16165809
43microtubule anchoring (GO:0034453)3.15358267
44sister chromatid segregation (GO:0000819)3.15257802
45synapsis (GO:0007129)3.14029148
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13896600
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10906740
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10401007
49corticosteroid receptor signaling pathway (GO:0031958)3.10318197
50regulation of mitotic spindle checkpoint (GO:1903504)3.10228416
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10228416
52histone H2A monoubiquitination (GO:0035518)3.08603899
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07642980
54chromatin remodeling at centromere (GO:0031055)3.07097219
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.06944805
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06944805
57mitotic nuclear envelope disassembly (GO:0007077)3.06882338
58non-recombinational repair (GO:0000726)3.06248295
59double-strand break repair via nonhomologous end joining (GO:0006303)3.06248295
60embryonic foregut morphogenesis (GO:0048617)3.06035956
61cell adhesion mediated by integrin (GO:0033627)3.02570535
62nuclear envelope disassembly (GO:0051081)3.01870952
63membrane disassembly (GO:0030397)3.01870952
64regulation of centrosome cycle (GO:0046605)3.01026043
65pore complex assembly (GO:0046931)2.99104500
66postreplication repair (GO:0006301)2.97933317
67gastrulation with mouth forming second (GO:0001702)2.97645238
68negative regulation of fatty acid transport (GO:2000192)2.97377822
69regulation of nucleobase-containing compound transport (GO:0032239)2.97321212
70folic acid-containing compound biosynthetic process (GO:0009396)2.97268623
71kinetochore organization (GO:0051383)2.97186539
72negative regulation of DNA recombination (GO:0045910)2.96339544
73positive regulation of developmental pigmentation (GO:0048087)2.95177425
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94617188
75regulation of fatty acid beta-oxidation (GO:0031998)2.94319666
76sister chromatid cohesion (GO:0007062)2.93842180
77epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92505923
78CENP-A containing nucleosome assembly (GO:0034080)2.91328659
79paraxial mesoderm development (GO:0048339)2.88518046
80regulation of mitotic spindle organization (GO:0060236)2.85427420
81indolalkylamine metabolic process (GO:0006586)2.85322609
82intra-S DNA damage checkpoint (GO:0031573)2.83968125
83indole-containing compound catabolic process (GO:0042436)2.82062298
84indolalkylamine catabolic process (GO:0046218)2.82062298
85tryptophan catabolic process (GO:0006569)2.82062298
86RNA stabilization (GO:0043489)2.79667658
87mRNA stabilization (GO:0048255)2.79667658
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.79575941
89axon extension involved in axon guidance (GO:0048846)2.79575941
90histone exchange (GO:0043486)2.78985539
91attachment of spindle microtubules to kinetochore (GO:0008608)2.78705369
92regulation of spindle organization (GO:0090224)2.78495608
93DNA replication-dependent nucleosome assembly (GO:0006335)2.78189371
94DNA replication-dependent nucleosome organization (GO:0034723)2.78189371
95DNA duplex unwinding (GO:0032508)2.78096076
96midgut development (GO:0007494)2.77954589
97photoreceptor cell maintenance (GO:0045494)2.77713458
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.77391844
99monoubiquitinated protein deubiquitination (GO:0035520)2.76917401
100DNA geometric change (GO:0032392)2.76753255
101negative regulation of histone methylation (GO:0031061)2.76444893
102cornea development in camera-type eye (GO:0061303)2.76368535
103double-strand break repair (GO:0006302)2.74658763
104cilium or flagellum-dependent cell motility (GO:0001539)2.74392783
105protein localization to chromosome, centromeric region (GO:0071459)2.73301469
106resolution of meiotic recombination intermediates (GO:0000712)2.71842533
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71205509
108chromatin assembly (GO:0031497)2.71018248
109microtubule organizing center organization (GO:0031023)2.67352862
110regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67242461
111negative regulation of neurotransmitter transport (GO:0051589)2.66608909
112mitotic sister chromatid segregation (GO:0000070)2.66434801
113regulation of hexokinase activity (GO:1903299)2.65802489
114regulation of glucokinase activity (GO:0033131)2.65802489
115gene silencing by RNA (GO:0031047)2.65573029
116centrosome organization (GO:0051297)2.64217464
117tryptophan metabolic process (GO:0006568)2.62927647
118germ cell migration (GO:0008354)2.62897126
119negative regulation of cell size (GO:0045792)2.62359746
120histone H2A acetylation (GO:0043968)2.62306772
121regulation of NFAT protein import into nucleus (GO:0051532)2.62256076
122spindle checkpoint (GO:0031577)2.62217361
123response to X-ray (GO:0010165)2.61254663
124cilium morphogenesis (GO:0060271)2.60089474
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.59768482
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.59589049
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.59026378
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59026378
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59026378
130nuclear envelope organization (GO:0006998)2.58113520
131kynurenine metabolic process (GO:0070189)2.56912616
132regulation of hippo signaling (GO:0035330)2.55770917
133regulation of helicase activity (GO:0051095)2.53280341
134regulation of mitotic sister chromatid separation (GO:0010965)2.52803025
135regulation of mitotic sister chromatid segregation (GO:0033047)2.52803025
136regulation of sister chromatid segregation (GO:0033045)2.52803025
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.52726972
138adherens junction assembly (GO:0034333)2.52669378
139negative regulation of neurotransmitter secretion (GO:0046929)2.52626557
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52053579
141mitotic spindle checkpoint (GO:0071174)2.51397608
142negative regulation of DNA repair (GO:0045738)2.50945837
143translesion synthesis (GO:0019985)2.50246951
144hindbrain development (GO:0030902)2.49886416
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49496390
146rRNA catabolic process (GO:0016075)2.47793171
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47703480
148cilium organization (GO:0044782)2.47379600
149kinetochore assembly (GO:0051382)2.47251094
150cilium assembly (GO:0042384)2.46838082
151mitotic cytokinesis (GO:0000281)2.46814199
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.46752352
153regulation of meiosis I (GO:0060631)2.46468889
154retinal cone cell development (GO:0046549)2.46022000
155positive regulation of histone H3-K4 methylation (GO:0051571)2.45992670
156establishment of nucleus localization (GO:0040023)2.45910032
157positive regulation of nuclease activity (GO:0032075)2.45888342
158glial cell proliferation (GO:0014009)2.45313451
159dorsal/ventral axis specification (GO:0009950)2.44711424
160DNA recombination (GO:0006310)2.44545468
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.44283626
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.44283626
163histone mRNA catabolic process (GO:0071044)2.44130269
164DNA-dependent DNA replication (GO:0006261)2.43043401
165regulation of pigment cell differentiation (GO:0050932)2.42752628
166protein K6-linked ubiquitination (GO:0085020)2.42031095
167regulation of SMAD protein import into nucleus (GO:0060390)2.41756372
168regulation of translational termination (GO:0006449)2.41693049
169regulation of nuclear cell cycle DNA replication (GO:0033262)2.41513616
170positive regulation of histone deacetylation (GO:0031065)2.40101625
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37313116
172positive regulation of glycogen biosynthetic process (GO:0045725)2.36364137
173positive regulation of chromosome segregation (GO:0051984)2.34614972
174protein export from nucleus (GO:0006611)2.33349571
175chromosome condensation (GO:0030261)2.32503189
176cell migration involved in sprouting angiogenesis (GO:0002042)2.32187559
177cellular response to epidermal growth factor stimulus (GO:0071364)2.31795955
178response to epidermal growth factor (GO:0070849)2.31758075
179protein localization to chromosome (GO:0034502)2.31699587
180chondrocyte proliferation (GO:0035988)2.30283982
181negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.29049723
182response to UV-C (GO:0010225)2.28767730
183positive regulation of epithelial to mesenchymal transition (GO:0010718)2.28734951
184gene silencing (GO:0016458)2.28591634
185DNA topological change (GO:0006265)2.28213329
186spindle assembly involved in mitosis (GO:0090307)2.27924538
187cytoskeleton-dependent cytokinesis (GO:0061640)2.27757027
188regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.27305871
189protein localization to endosome (GO:0036010)2.26487462
190nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.25301435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83117536
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.62514324
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.58590186
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.30117860
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.11518053
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.10295964
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87708088
8MYC_22102868_ChIP-Seq_BL_Human2.80713436
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78559678
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.78459931
11FUS_26573619_Chip-Seq_HEK293_Human2.78398594
12CLOCK_20551151_ChIP-Seq_293T_Human2.78297423
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75099227
14* EWS_26573619_Chip-Seq_HEK293_Human2.71632939
15GBX2_23144817_ChIP-Seq_PC3_Human2.71464808
16AR_21909140_ChIP-Seq_LNCAP_Human2.67027178
17VDR_22108803_ChIP-Seq_LS180_Human2.56452241
18TAF15_26573619_Chip-Seq_HEK293_Human2.55992327
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54892892
20ZNF274_21170338_ChIP-Seq_K562_Hela2.53125195
21* IGF1R_20145208_ChIP-Seq_DFB_Human2.52084254
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46362723
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35804707
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22943693
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22612016
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.21351735
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11233076
28P300_19829295_ChIP-Seq_ESCs_Human2.10768339
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05698860
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05654646
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01862164
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01159984
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.96044156
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.93737079
35* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85602286
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85471197
37ELK1_19687146_ChIP-ChIP_HELA_Human1.83143052
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79993233
39* ER_23166858_ChIP-Seq_MCF-7_Human1.79317421
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75783439
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75603338
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74125169
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73522700
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73486972
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.73172429
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73100397
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71552042
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69969822
49* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65719064
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65009821
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63742140
52STAT3_23295773_ChIP-Seq_U87_Human1.62525724
53SMAD4_21799915_ChIP-Seq_A2780_Human1.60934548
54TCF7_22412390_ChIP-Seq_EML_Mouse1.60787477
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.59161713
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58204412
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56341598
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55578836
59FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54876225
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.54037425
61KDM2B_26808549_Chip-Seq_DND41_Human1.52198879
62BRD4_25478319_ChIP-Seq_HGPS_Human1.50460950
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47871312
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47773234
65CHD1_26751641_Chip-Seq_LNCaP_Human1.47244447
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47215369
67CBP_20019798_ChIP-Seq_JUKART_Human1.47215369
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46905112
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46565177
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46376108
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45690592
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45543226
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45321318
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42946433
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42251932
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41393202
77TCF4_23295773_ChIP-Seq_U87_Human1.40890993
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.40094829
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39210575
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39083760
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.39010666
82* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38153969
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37072853
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36988647
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.36049772
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35701704
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35609643
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34951439
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.34690883
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34547120
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34519322
92BCAT_22108803_ChIP-Seq_LS180_Human1.34472828
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32626858
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32303344
95ATF3_27146783_Chip-Seq_COLON_Human1.31631787
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29975164
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29430931
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.28800059
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.28547068
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.27654187
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27545233
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27217838
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27183806
104IRF1_19129219_ChIP-ChIP_H3396_Human1.27063807
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.26991331
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26786859
107MYC_18940864_ChIP-ChIP_HL60_Human1.26732978
108* AR_25329375_ChIP-Seq_VCAP_Human1.26308176
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25993715
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25682071
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.25268479
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24610729
113ZNF263_19887448_ChIP-Seq_K562_Human1.23473525
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23081961
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23081961
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22986650
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22661446
118TCF4_22108803_ChIP-Seq_LS180_Human1.22328919
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22064005
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.21701599
121* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20166352
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.20093437
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19994103
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.18247760
125RXR_22158963_ChIP-Seq_LIVER_Mouse1.18053568
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17886888
127AR_21572438_ChIP-Seq_LNCaP_Human1.17736630
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17368909
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17355784
130FOXO3_23340844_ChIP-Seq_DLD1_Human1.16597624
131P53_22387025_ChIP-Seq_ESCs_Mouse1.15682928
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15454835
133ELK3_25401928_ChIP-Seq_HUVEC_Human1.15208936
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14279568
135NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14245090
136TRIM28_21343339_ChIP-Seq_HEK293_Human1.13020592
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12959354
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12803944
139* RUNX2_22187159_ChIP-Seq_PCA_Human1.12758061
140* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12731028
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12179396
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11870715
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10427588
144UBF1/2_26484160_Chip-Seq_HMECs_Human1.09804757
145GATA1_22025678_ChIP-Seq_K562_Human1.09639705
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09324870
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09151504
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09151504
149* SOX2_19829295_ChIP-Seq_ESCs_Human1.08621124
150* NANOG_19829295_ChIP-Seq_ESCs_Human1.08621124
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08567718
152KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07985038
153CMYC_18555785_Chip-Seq_ESCs_Mouse1.07307252
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07270039
155P300_18555785_Chip-Seq_ESCs_Mouse1.07219276
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06786827
157* VDR_23849224_ChIP-Seq_CD4+_Human1.06641441
158CDX2_22108803_ChIP-Seq_LS180_Human1.06384459
159RNF2_27304074_Chip-Seq_NSC_Mouse1.06018540
160NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05841403
161GATA6_25053715_ChIP-Seq_YYC3_Human1.05378831
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05355338
163LXR_22158963_ChIP-Seq_LIVER_Mouse1.05344107
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05287971
165MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05031609
166NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04526114
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03125879
168NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02707723
169STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02505674
170TP53_22573176_ChIP-Seq_HFKS_Human1.02141464
171CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01617729
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00736865
173TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00390129
174* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00179645
175EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00024525
176ISL1_27105846_Chip-Seq_CPCs_Mouse0.99630712
177SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98490139
178TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97108521
179NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96596603
180PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96513120
181FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95443484
182CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94969322
183KDM2B_26808549_Chip-Seq_K562_Human0.94226994
184VDR_21846776_ChIP-Seq_THP-1_Human0.94218443
185FOXA2_19822575_ChIP-Seq_HepG2_Human0.93248348
186SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90380208
187NCOR1_26117541_ChIP-Seq_K562_Human0.90136774
188ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89269031
189TP53_22127205_ChIP-Seq_IMR90_Human0.88509495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.51408909
2MP0003705_abnormal_hypodermis_morpholog4.73601994
3MP0008877_abnormal_DNA_methylation3.26673712
4MP0010352_gastrointestinal_tract_polyps3.16894449
5MP0005076_abnormal_cell_differentiation2.98368058
6MP0008438_abnormal_cutaneous_collagen2.84870382
7MP0000537_abnormal_urethra_morphology2.64133367
8MP0008058_abnormal_DNA_repair2.64000923
9MP0002102_abnormal_ear_morphology2.61995463
10MP0000569_abnormal_digit_pigmentation2.61373760
11MP0009053_abnormal_anal_canal2.54830459
12MP0002009_preneoplasia2.54404671
13MP0002938_white_spotting2.40129478
14MP0010234_abnormal_vibrissa_follicle2.38472737
15MP0003136_yellow_coat_color2.24859982
16MP0006292_abnormal_olfactory_placode2.20786174
17MP0003787_abnormal_imprinting2.19021596
18MP0010030_abnormal_orbit_morphology2.15721593
19MP0009697_abnormal_copulation2.08919214
20MP0010307_abnormal_tumor_latency2.08108328
21MP0003300_gastrointestinal_ulcer2.04342109
22MP0002638_abnormal_pupillary_reflex1.94529660
23MP0000733_abnormal_muscle_development1.90309273
24MP0005187_abnormal_penis_morphology1.86042828
25MP0004197_abnormal_fetal_growth/weight/1.84637730
26MP0002877_abnormal_melanocyte_morpholog1.82198771
27MP0005253_abnormal_eye_physiology1.81321744
28MP0003123_paternal_imprinting1.78389316
29MP0005551_abnormal_eye_electrophysiolog1.71911080
30MP0006054_spinal_hemorrhage1.71219442
31MP0006072_abnormal_retinal_apoptosis1.70560180
32MP0003283_abnormal_digestive_organ1.70055617
33MP0000383_abnormal_hair_follicle1.66887468
34MP0000427_abnormal_hair_cycle1.62074813
35MP0003115_abnormal_respiratory_system1.61569689
36MP0003252_abnormal_bile_duct1.60612229
37MP0001730_embryonic_growth_arrest1.59994882
38MP0002837_dystrophic_cardiac_calcinosis1.56470481
39MP0003566_abnormal_cell_adhesion1.55668729
40MP0000428_abnormal_craniofacial_morphol1.54748143
41MP0003890_abnormal_embryonic-extraembry1.54566450
42MP0004233_abnormal_muscle_weight1.54507220
43MP0001915_intracranial_hemorrhage1.51981256
44MP0002084_abnormal_developmental_patter1.50989601
45MP0009384_cardiac_valve_regurgitation1.49989451
46MP0000372_irregular_coat_pigmentation1.48469531
47MP0005623_abnormal_meninges_morphology1.47443323
48MP0005248_abnormal_Harderian_gland1.46772541
49MP0003121_genomic_imprinting1.45244394
50MP0010094_abnormal_chromosome_stability1.45211499
51MP0005503_abnormal_tendon_morphology1.44833444
52MP0001299_abnormal_eye_distance/1.44298281
53MP0000350_abnormal_cell_proliferation1.43014557
54MP0003195_calcinosis1.40644553
55MP0002088_abnormal_embryonic_growth/wei1.40493192
56MP0002160_abnormal_reproductive_system1.40242106
57MP0005380_embryogenesis_phenotype1.39544023
58MP0001672_abnormal_embryogenesis/_devel1.39544023
59MP0003984_embryonic_growth_retardation1.39327606
60MP0003077_abnormal_cell_cycle1.39316832
61MP0003091_abnormal_cell_migration1.38893497
62MP0003111_abnormal_nucleus_morphology1.38879545
63MP0001849_ear_inflammation1.38280739
64MP0002085_abnormal_embryonic_tissue1.36997087
65MP0002086_abnormal_extraembryonic_tissu1.35873660
66MP0005275_abnormal_skin_tensile1.34472541
67MP0002092_abnormal_eye_morphology1.34420572
68MP0001697_abnormal_embryo_size1.32336873
69MP0003718_maternal_effect1.30495715
70MP0005171_absent_coat_pigmentation1.29646469
71MP0003942_abnormal_urinary_system1.29421590
72MP0005075_abnormal_melanosome_morpholog1.27686801
73MP0000631_abnormal_neuroendocrine_gland1.27403008
74MP0009672_abnormal_birth_weight1.26087336
75MP0002697_abnormal_eye_size1.25309958
76MP0002139_abnormal_hepatobiliary_system1.24966706
77MP0003937_abnormal_limbs/digits/tail_de1.24902363
78MP0003935_abnormal_craniofacial_develop1.24677420
79MP0005023_abnormal_wound_healing1.23515997
80MP0003943_abnormal_hepatobiliary_system1.22230966
81MP0003119_abnormal_digestive_system1.22225814
82MP0005220_abnormal_exocrine_pancreas1.21844278
83MP0005174_abnormal_tail_pigmentation1.21657989
84MP0009703_decreased_birth_body1.21298590
85MP0008961_abnormal_basal_metabolism1.20271995
86MP0003385_abnormal_body_wall1.20068070
87MP0004215_abnormal_myocardial_fiber1.16471766
88MP0002896_abnormal_bone_mineralization1.15946453
89MP0004957_abnormal_blastocyst_morpholog1.15283821
90MP0005389_reproductive_system_phenotype1.15244559
91MP0004147_increased_porphyrin_level1.14499425
92MP0000534_abnormal_ureter_morphology1.14337786
93MP0001929_abnormal_gametogenesis1.14126455
94MP0005367_renal/urinary_system_phenotyp1.13676263
95MP0000516_abnormal_urinary_system1.13676263
96MP0003786_premature_aging1.11897532
97MP0001293_anophthalmia1.10966586
98MP0004272_abnormal_basement_membrane1.09847395
99MP0009046_muscle_twitch1.09271903
100MP0001984_abnormal_olfaction1.08633925
101MP0000778_abnormal_nervous_system1.08477680
102MP0004808_abnormal_hematopoietic_stem1.08085155
103MP0001919_abnormal_reproductive_system1.07978469
104MP0002089_abnormal_postnatal_growth/wei1.07823845
105MP0005646_abnormal_pituitary_gland1.07551562
106MP0002080_prenatal_lethality1.06907647
107MP0002282_abnormal_trachea_morphology1.05999376
108MP0002234_abnormal_pharynx_morphology1.05936610
109MP0005391_vision/eye_phenotype1.04718619
110MP0005645_abnormal_hypothalamus_physiol1.03960844
111MP0002090_abnormal_vision1.03795352
112MP0006276_abnormal_autonomic_nervous1.03719685
113MP0010368_abnormal_lymphatic_system1.03577818
114MP0010678_abnormal_skin_adnexa1.03429665
115MP0002932_abnormal_joint_morphology1.03266317
116MP0008007_abnormal_cellular_replicative1.03121051
117MP0008995_early_reproductive_senescence1.03100614
118MP0000003_abnormal_adipose_tissue1.03086293
119MP0003279_aneurysm1.02894399
120MP0002925_abnormal_cardiovascular_devel1.02517802
121MP0003567_abnormal_fetal_cardiomyocyte1.02138671
122MP0001324_abnormal_eye_pigmentation1.01929758
123MP0003698_abnormal_male_reproductive1.01841109
124MP0008789_abnormal_olfactory_epithelium0.99220111
125MP0002751_abnormal_autonomic_nervous0.98167486
126MP0001485_abnormal_pinna_reflex0.97918529
127MP0002210_abnormal_sex_determination0.97763677
128MP0000653_abnormal_sex_gland0.96953961
129MP0004142_abnormal_muscle_tone0.95527192
130MP0005257_abnormal_intraocular_pressure0.94541186
131MP0004185_abnormal_adipocyte_glucose0.94293806
132MP0001145_abnormal_male_reproductive0.93747425
133MP0002095_abnormal_skin_pigmentation0.93732974
134MP0000432_abnormal_head_morphology0.93297549
135MP0005360_urolithiasis0.93255917
136MP0002396_abnormal_hematopoietic_system0.92736232
137MP0002111_abnormal_tail_morphology0.92340973
138MP0002928_abnormal_bile_duct0.90654072
139MP0003755_abnormal_palate_morphology0.90538655
140MP0004043_abnormal_pH_regulation0.90291789
141MP0003880_abnormal_central_pattern0.89991025
142MP0000647_abnormal_sebaceous_gland0.89066959
143MP0001486_abnormal_startle_reflex0.88412924
144MP0000767_abnormal_smooth_muscle0.88116073
145MP0002736_abnormal_nociception_after0.85541328
146MP0009780_abnormal_chondrocyte_physiolo0.85458271
147MP0008932_abnormal_embryonic_tissue0.85138762
148MP0005195_abnormal_posterior_eye0.85048847
149MP0005365_abnormal_bile_salt0.83384725
150MP0002233_abnormal_nose_morphology0.83062570
151MP0004133_heterotaxia0.82944928
152MP0010630_abnormal_cardiac_muscle0.82237884
153MP0003122_maternal_imprinting0.82138610
154MP0008872_abnormal_physiological_respon0.80739247
155MP0001119_abnormal_female_reproductive0.80352263
156MP0001529_abnormal_vocalization0.79540024
157MP0000266_abnormal_heart_morphology0.78744400
158MP0003861_abnormal_nervous_system0.78594350
159MP0001286_abnormal_eye_development0.78230652
160MP0003693_abnormal_embryo_hatching0.77686954
161MP0002116_abnormal_craniofacial_bone0.77051073
162MP0001968_abnormal_touch/_nociception0.76854826
163MP0005508_abnormal_skeleton_morphology0.75577650
164MP0006035_abnormal_mitochondrial_morpho0.75451825
165MP0001188_hyperpigmentation0.75364838
166MP0004264_abnormal_extraembryonic_tissu0.75207515
167MP0004134_abnormal_chest_morphology0.74546831
168MP0002735_abnormal_chemical_nociception0.73553488
169MP0002128_abnormal_blood_circulation0.72064880
170MP0005499_abnormal_olfactory_system0.71475995
171MP0005394_taste/olfaction_phenotype0.71475995
172MP0005386_behavior/neurological_phenoty0.71371508
173MP0004924_abnormal_behavior0.71371508
174MP0002109_abnormal_limb_morphology0.70858480

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.92326248
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.92326248
3Pancreatic cysts (HP:0001737)3.77673031
4Chromsome breakage (HP:0040012)3.57492946
5Protrusio acetabuli (HP:0003179)3.49546538
6Shallow orbits (HP:0000586)3.45768408
7True hermaphroditism (HP:0010459)3.40800352
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40614801
9Abnormality of chromosome stability (HP:0003220)3.34179756
10Pancreatic fibrosis (HP:0100732)3.31361091
11Abnormality of the 4th metacarpal (HP:0010012)3.29567146
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.13357376
13Abnormality of the renal cortex (HP:0011035)3.02139133
14Subacute progressive viral hepatitis (HP:0006572)3.00860086
15Hyperventilation (HP:0002883)2.88627728
16Cerebral aneurysm (HP:0004944)2.86113530
17Cortical dysplasia (HP:0002539)2.85344393
18Abnormality of midbrain morphology (HP:0002418)2.84670638
19Molar tooth sign on MRI (HP:0002419)2.84670638
20Chronic hepatic failure (HP:0100626)2.78991124
21Nephronophthisis (HP:0000090)2.78846527
22Renal cortical cysts (HP:0000803)2.77033658
23Meckel diverticulum (HP:0002245)2.67635533
24Abnormality of the renal medulla (HP:0100957)2.64538559
25Abnormality of the ileum (HP:0001549)2.64077043
26Hyperacusis (HP:0010780)2.58303439
27Intestinal atresia (HP:0011100)2.57669036
28Macroorchidism (HP:0000053)2.55756372
29Ankle contracture (HP:0006466)2.54553739
30Premature rupture of membranes (HP:0001788)2.54311868
31Volvulus (HP:0002580)2.49916007
32Mitral valve prolapse (HP:0001634)2.49759663
33Gaze-evoked nystagmus (HP:0000640)2.49024614
34Bowel diverticulosis (HP:0005222)2.47090718
35Abnormality of the labia minora (HP:0012880)2.46990943
36Sloping forehead (HP:0000340)2.44382867
37Lymphangioma (HP:0100764)2.42835234
38Increased density of long bones (HP:0006392)2.42271205
39Deviation of the thumb (HP:0009603)2.41776919
40Renal duplication (HP:0000075)2.39262172
41Ankyloglossia (HP:0010296)2.38556731
42Increased nuchal translucency (HP:0010880)2.37772391
43Fair hair (HP:0002286)2.35246300
44Dilatation of the ascending aorta (HP:0005111)2.34072981
45Clubbing of toes (HP:0100760)2.32812192
46Renovascular hypertension (HP:0100817)2.32780590
47Congenital stationary night blindness (HP:0007642)2.32502709
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.32388465
49Hypoplasia of the fovea (HP:0007750)2.32388465
50Medial flaring of the eyebrow (HP:0010747)2.31414880
51Aortic aneurysm (HP:0004942)2.30649703
52Enlarged penis (HP:0000040)2.28595714
53Abnormality of the preputium (HP:0100587)2.28135502
54Deviation of the hallux (HP:0010051)2.28029529
55Heterotopia (HP:0002282)2.27400961
56Astrocytoma (HP:0009592)2.27149448
57Abnormality of the astrocytes (HP:0100707)2.27149448
58Hallux valgus (HP:0001822)2.27058183
59Abnormality of oral frenula (HP:0000190)2.26139340
60Central scotoma (HP:0000603)2.24346238
61Cystic liver disease (HP:0006706)2.24055809
62Tubulointerstitial nephritis (HP:0001970)2.23859695
63Proximal placement of thumb (HP:0009623)2.20003953
64Bladder diverticulum (HP:0000015)2.19791724
65Wrist flexion contracture (HP:0001239)2.15513359
66Genu recurvatum (HP:0002816)2.14077068
67Elfin facies (HP:0004428)2.13975809
68Ectopic kidney (HP:0000086)2.13628604
69Bile duct proliferation (HP:0001408)2.12034025
70Abnormal biliary tract physiology (HP:0012439)2.12034025
71Rectal prolapse (HP:0002035)2.06319018
72Pseudobulbar signs (HP:0002200)2.05825385
73Duodenal stenosis (HP:0100867)2.05041866
74Small intestinal stenosis (HP:0012848)2.05041866
75Rhabdomyosarcoma (HP:0002859)2.04812888
76Aqueductal stenosis (HP:0002410)2.04437283
77Abnormality of the fovea (HP:0000493)2.04149989
78Abnormality of the duodenum (HP:0002246)2.04005301
79Long toe (HP:0010511)2.03957487
80Attenuation of retinal blood vessels (HP:0007843)2.03761475
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.03168916
82Cutaneous melanoma (HP:0012056)1.99501458
83Cervical subluxation (HP:0003308)1.99493546
84Aneurysm (HP:0002617)1.99482047
85Abnormality of macular pigmentation (HP:0008002)1.99463038
86Supernumerary spleens (HP:0009799)1.97858039
87Exostoses (HP:0100777)1.96905014
88Hepatoblastoma (HP:0002884)1.96001540
89Back pain (HP:0003418)1.95748490
90Oligodactyly (hands) (HP:0001180)1.93364079
91Pancreatic islet-cell hyperplasia (HP:0004510)1.93146914
92Aortic dissection (HP:0002647)1.92759663
93Malignant gastrointestinal tract tumors (HP:0006749)1.91485001
94Gastrointestinal carcinoma (HP:0002672)1.91485001
95Mesomelia (HP:0003027)1.91322894
96Birth length less than 3rd percentile (HP:0003561)1.91045436
97Thyroiditis (HP:0100646)1.90645316
98Neoplasm of the adrenal cortex (HP:0100641)1.90343708
99Spastic diplegia (HP:0001264)1.90175270
100Congenital primary aphakia (HP:0007707)1.89674339
101Genital tract atresia (HP:0001827)1.88767870
102Deep venous thrombosis (HP:0002625)1.88539495
103Protruding tongue (HP:0010808)1.88142576
104Postaxial foot polydactyly (HP:0001830)1.87687793
105Progressive inability to walk (HP:0002505)1.87366506
106Trigonocephaly (HP:0000243)1.87271501
107Narrow palate (HP:0000189)1.84630720
108Ependymoma (HP:0002888)1.84325975
109Medulloblastoma (HP:0002885)1.83814378
110Astigmatism (HP:0000483)1.83237125
111Tubular atrophy (HP:0000092)1.83200533
112Fibrous tissue neoplasm (HP:0012316)1.82293984
113Nephroblastoma (Wilms tumor) (HP:0002667)1.81378404
114Gait imbalance (HP:0002141)1.81187278
115Male pseudohermaphroditism (HP:0000037)1.81128569
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.80965863
117Myelodysplasia (HP:0002863)1.80759636
118Radial bowing (HP:0002986)1.80738248
119Broad thumb (HP:0011304)1.80647116
120Fibroma (HP:0010614)1.80478997
121Vaginal atresia (HP:0000148)1.80418831
122Broad-based gait (HP:0002136)1.78468830
123Glioma (HP:0009733)1.78106503
124Colon cancer (HP:0003003)1.77775607
125Nephrogenic diabetes insipidus (HP:0009806)1.77307362
126Febrile seizures (HP:0002373)1.77304032
127Ulnar bowing (HP:0003031)1.76772923
128Overriding aorta (HP:0002623)1.76746972
129Abnormality of the calcaneus (HP:0008364)1.76045217
130Syringomyelia (HP:0003396)1.75768650
131Spinal cord lesions (HP:0100561)1.75768650
132Abnormal lung lobation (HP:0002101)1.74702023
133Broad metatarsal (HP:0001783)1.74667418
134Widely spaced teeth (HP:0000687)1.74419517
135Optic nerve hypoplasia (HP:0000609)1.74202015
136Transitional cell carcinoma of the bladder (HP:0006740)1.73804865
137Acute myeloid leukemia (HP:0004808)1.73049571
138Anencephaly (HP:0002323)1.72901029
139Generalized hypopigmentation of hair (HP:0011358)1.72336872
140Obsessive-compulsive behavior (HP:0000722)1.72246457
141Thin bony cortex (HP:0002753)1.71754408
142Embryonal renal neoplasm (HP:0011794)1.71184503
143Absent speech (HP:0001344)1.70712141
144Duplicated collecting system (HP:0000081)1.70568783
145Triphalangeal thumb (HP:0001199)1.70056918
146Dandy-Walker malformation (HP:0001305)1.69310018
147Drooling (HP:0002307)1.69019482
148Congenital hepatic fibrosis (HP:0002612)1.68449787
149Hand muscle atrophy (HP:0009130)1.68434370
150Skull defect (HP:0001362)1.68330841
151Leiomyosarcoma (HP:0100243)1.68027444
152Uterine leiomyosarcoma (HP:0002891)1.68027444
153Deep philtrum (HP:0002002)1.67984823
154Abnormality of the carotid arteries (HP:0005344)1.67906991
155Cupped ear (HP:0000378)1.67733699
156Pelvic girdle muscle weakness (HP:0003749)1.67681803
157Sclerocornea (HP:0000647)1.67613283
158Chorioretinal atrophy (HP:0000533)1.67443722
159Long eyelashes (HP:0000527)1.65308421
160Hypoplastic iliac wings (HP:0002866)1.65263118
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65252076
162Absent radius (HP:0003974)1.65087551
163Biliary tract neoplasm (HP:0100574)1.64667521
164Papillary thyroid carcinoma (HP:0002895)1.64595579
165Pointed chin (HP:0000307)1.64561657
166Selective tooth agenesis (HP:0001592)1.64345883
167Buphthalmos (HP:0000557)1.63659282
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63420993
169Absent frontal sinuses (HP:0002688)1.63273680
170Termporal pattern (HP:0011008)1.63154409
171Insidious onset (HP:0003587)1.63154409
172Broad palm (HP:0001169)1.63028420
173Highly arched eyebrow (HP:0002553)1.62999168
174Peritonitis (HP:0002586)1.62879116
175Oligohydramnios (HP:0001562)1.62801146
176Striae distensae (HP:0001065)1.62713927
177Vertebral arch anomaly (HP:0008438)1.62609130
178Scotoma (HP:0000575)1.62450216
179Distal upper limb amyotrophy (HP:0007149)1.62252705
180Upper limb amyotrophy (HP:0009129)1.62252705
181Preaxial hand polydactyly (HP:0001177)1.62163669
182Abnormal biliary tract morphology (HP:0012440)1.62141380
183Small hand (HP:0200055)1.62132942
184Camptodactyly of toe (HP:0001836)1.61866121
185Abnormality of the renal collecting system (HP:0004742)1.61431882
186Abnormality of the distal phalanx of the thumb (HP:0009617)1.61131076
187Hip dysplasia (HP:0001385)1.61000432
188Abnormality of the pons (HP:0007361)1.60456167
189Disproportionate tall stature (HP:0001519)1.59713063
190Bladder neoplasm (HP:0009725)1.59671329
191Bladder carcinoma (HP:0002862)1.59671329
192Osteolytic defects of the hand bones (HP:0009699)1.59576514
193Osteolytic defects of the phalanges of the hand (HP:0009771)1.59576514
194Cutis marmorata (HP:0000965)1.59057714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.83172363
2TRIB33.77659517
3LATS13.43971163
4PASK2.98376931
5MAP3K102.81358802
6NUAK12.76966513
7EEF2K2.73340602
8CDK122.50919285
9CDC72.48279803
10ACVR1B2.47557675
11MKNK22.46241768
12SCYL22.36643658
13TTN2.34722648
14EIF2AK32.34565910
15WEE12.28443070
16ZAK2.25953845
17BMPR1B2.25627859
18WNK32.12523852
19SIK12.10442584
20PDGFRA2.10031262
21TRIM282.02900665
22MAP3K42.02055588
23MKNK12.00276413
24PTK61.92978927
25PNCK1.78357801
26CASK1.72708967
27PLK41.67631128
28RIPK11.67501535
29MAP4K21.67378924
30LATS21.65905276
31STK31.63758147
32NEK11.62519325
33STK38L1.61123160
34NEK21.54916872
35DDR21.50146316
36KSR11.47763907
37TNIK1.47489621
38CDK61.46778544
39AKT31.46106190
40VRK11.45477602
41MTOR1.44347185
42CAMK1D1.43581025
43MAPK131.42213945
44SRPK11.39465902
45INSRR1.31763540
46PAK41.30720188
47PLK21.30616041
48MST41.30346580
49STK391.29745429
50CAMKK11.28615790
51TAF11.28569151
52FGFR11.27470691
53FGFR21.26490741
54EIF2AK11.23709692
55FRK1.23480738
56ERBB31.21770946
57PAK21.20496464
58BCR1.14082170
59STK101.10560140
60LRRK21.06454295
61PINK11.03917486
62CAMK1G1.03232857
63ALK1.02803720
64OXSR11.02489406
65NLK1.02103549
66BUB11.00723060
67RET1.00174672
68FGFR31.00125044
69CDK40.99379721
70TSSK60.97117654
71PDGFRB0.96757508
72MAP3K80.95159246
73TGFBR10.94425964
74GRK10.93694239
75TTK0.92949079
76RPS6KA40.92592924
77ICK0.92388395
78ERN10.92240075
79MAP2K70.90209882
80BMX0.89750236
81PTK20.89560456
82FLT30.89032337
83EPHB20.87198265
84CCNB10.86851896
85ERBB20.84863662
86NEK90.83853114
87MARK10.82911674
88CSNK1G10.80870006
89ADRBK20.80334941
90ATR0.78716113
91TEC0.78509946
92KSR20.77971190
93BRD40.77646560
94CDK30.77570683
95MELK0.77137163
96PLK30.77075970
97PIK3CG0.75627552
98CHEK10.75367550
99ERBB40.74741051
100FGFR40.73772529
101RPS6KB20.73210446
102DYRK1B0.73143285
103SGK20.73084941
104EIF2AK20.69789191
105PAK30.69044528
106CAMKK20.68061196
107TLK10.67583668
108DMPK0.66927190
109CHEK20.66209682
110BRSK20.66163522
111PTK2B0.65107088
112PBK0.64527800
113AURKB0.61941335
114PRKCE0.59753598
115PAK60.58806940
116PLK10.57769050
117YES10.56861900
118CDK20.56432911
119ATM0.56363441
120CSNK1D0.55584688
121MAP3K20.53128681
122TYRO30.52654275
123CSNK1G30.48962142
124MUSK0.48959649
125PRKD30.48527460
126EPHA30.48284668
127CDK90.48047790
128CDK10.48039854
129FER0.47777570
130DYRK30.47529723
131MARK30.46081542
132OBSCN0.44827691
133CSNK1A1L0.43298139
134MET0.42951104
135DYRK1A0.42888617
136PRKCG0.40390382
137BRSK10.40233796
138TAOK30.40204707
139CHUK0.39739983
140TAOK10.39687280
141PRKDC0.39497491
142WNK40.39284533
143TNK20.38935057
144MAP3K70.38565469
145SIK20.38030250
146TESK20.37142962
147STK40.36922574
148CDK70.35343757
149EPHA40.35021672
150MAPK140.34973976
151ILK0.34878368
152CSNK1E0.33310247
153PRKAA10.32500121
154MAPK90.32327352
155RPS6KA20.32316625
156TESK10.31939484
157AKT20.31708989
158PDK20.31199023
159RPS6KB10.30884285
160BMPR20.30527045
161CSNK1G20.30294482
162VRK20.30050199
163PRKAA20.29909198

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.09633495
2Homologous recombination_Homo sapiens_hsa034403.66562640
3Fanconi anemia pathway_Homo sapiens_hsa034603.57909831
4Mismatch repair_Homo sapiens_hsa034302.84393095
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33122467
6Propanoate metabolism_Homo sapiens_hsa006402.32929116
7Protein export_Homo sapiens_hsa030602.16516785
8Nucleotide excision repair_Homo sapiens_hsa034202.10186229
9Nitrogen metabolism_Homo sapiens_hsa009102.08801492
10Butanoate metabolism_Homo sapiens_hsa006502.03857620
11Chronic myeloid leukemia_Homo sapiens_hsa052202.02539134
12Basal transcription factors_Homo sapiens_hsa030222.02238646
13RNA degradation_Homo sapiens_hsa030181.94279146
14Lysine degradation_Homo sapiens_hsa003101.93200577
15MicroRNAs in cancer_Homo sapiens_hsa052061.91925602
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79638957
17mTOR signaling pathway_Homo sapiens_hsa041501.77703117
18Cell cycle_Homo sapiens_hsa041101.75097258
19Phototransduction_Homo sapiens_hsa047441.73884508
20Adherens junction_Homo sapiens_hsa045201.72477702
21One carbon pool by folate_Homo sapiens_hsa006701.68445403
22Small cell lung cancer_Homo sapiens_hsa052221.66206773
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66105859
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65716164
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65281044
26Endometrial cancer_Homo sapiens_hsa052131.63415744
27Colorectal cancer_Homo sapiens_hsa052101.59317405
28Hippo signaling pathway_Homo sapiens_hsa043901.59045068
29Proteoglycans in cancer_Homo sapiens_hsa052051.58316975
30RNA polymerase_Homo sapiens_hsa030201.57496877
31Pancreatic cancer_Homo sapiens_hsa052121.55836433
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.52886430
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49682498
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48728314
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45632358
36Basal cell carcinoma_Homo sapiens_hsa052171.45389466
37Bladder cancer_Homo sapiens_hsa052191.41487531
38Focal adhesion_Homo sapiens_hsa045101.40434681
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.37622673
40Non-small cell lung cancer_Homo sapiens_hsa052231.36277153
41Taste transduction_Homo sapiens_hsa047421.35729278
42Viral myocarditis_Homo sapiens_hsa054161.34055406
43Selenocompound metabolism_Homo sapiens_hsa004501.32485535
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31585378
45Glioma_Homo sapiens_hsa052141.30940494
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30121509
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26026811
48Circadian rhythm_Homo sapiens_hsa047101.23927753
49Viral carcinogenesis_Homo sapiens_hsa052031.22299466
50p53 signaling pathway_Homo sapiens_hsa041151.21917499
51mRNA surveillance pathway_Homo sapiens_hsa030151.21464437
52Nicotine addiction_Homo sapiens_hsa050331.19993244
53Caffeine metabolism_Homo sapiens_hsa002321.19155628
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17027795
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.16783247
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16669135
57RNA transport_Homo sapiens_hsa030131.14337503
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14073118
59TGF-beta signaling pathway_Homo sapiens_hsa043501.14025950
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13852782
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13505836
62ABC transporters_Homo sapiens_hsa020101.13279614
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10301768
64Renal cell carcinoma_Homo sapiens_hsa052111.09697690
65HTLV-I infection_Homo sapiens_hsa051661.07372463
66Linoleic acid metabolism_Homo sapiens_hsa005911.07171858
67Prostate cancer_Homo sapiens_hsa052151.06406953
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04578617
69Olfactory transduction_Homo sapiens_hsa047401.03922538
70Purine metabolism_Homo sapiens_hsa002301.03642558
71ECM-receptor interaction_Homo sapiens_hsa045121.03330101
72Steroid biosynthesis_Homo sapiens_hsa001001.02612775
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01238636
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.99282004
75Insulin resistance_Homo sapiens_hsa049310.97569718
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96985442
77Systemic lupus erythematosus_Homo sapiens_hsa053220.96352223
78Ether lipid metabolism_Homo sapiens_hsa005650.95241169
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.94709993
80Arginine biosynthesis_Homo sapiens_hsa002200.94629582
81Notch signaling pathway_Homo sapiens_hsa043300.94601588
82AMPK signaling pathway_Homo sapiens_hsa041520.94565309
83Dorso-ventral axis formation_Homo sapiens_hsa043200.92244337
84Base excision repair_Homo sapiens_hsa034100.91325883
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89497391
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89171999
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.88424220
88Thyroid cancer_Homo sapiens_hsa052160.86955896
89Biosynthesis of amino acids_Homo sapiens_hsa012300.86404113
90Hedgehog signaling pathway_Homo sapiens_hsa043400.85583394
91Insulin signaling pathway_Homo sapiens_hsa049100.85447984
92Hepatitis B_Homo sapiens_hsa051610.84888460
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83980181
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83027012
95Spliceosome_Homo sapiens_hsa030400.81774673
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80768638
97FoxO signaling pathway_Homo sapiens_hsa040680.79344516
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78218786
99Oocyte meiosis_Homo sapiens_hsa041140.76074885
100Alcoholism_Homo sapiens_hsa050340.75931125
101Melanoma_Homo sapiens_hsa052180.75656295
102Type II diabetes mellitus_Homo sapiens_hsa049300.73982100
103Amoebiasis_Homo sapiens_hsa051460.73858865
104Estrogen signaling pathway_Homo sapiens_hsa049150.72596309
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72530690
106Pathways in cancer_Homo sapiens_hsa052000.72330515
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71297366
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69198224
109Prolactin signaling pathway_Homo sapiens_hsa049170.68934969
110DNA replication_Homo sapiens_hsa030300.68376079
111Pyrimidine metabolism_Homo sapiens_hsa002400.68042658
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67843769
113Wnt signaling pathway_Homo sapiens_hsa043100.67076614
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66763833
115Glucagon signaling pathway_Homo sapiens_hsa049220.66372124
116Axon guidance_Homo sapiens_hsa043600.65373766
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64691512
118Peroxisome_Homo sapiens_hsa041460.64385558
119Morphine addiction_Homo sapiens_hsa050320.63093793
120Serotonergic synapse_Homo sapiens_hsa047260.62959015
121beta-Alanine metabolism_Homo sapiens_hsa004100.62154372
122ErbB signaling pathway_Homo sapiens_hsa040120.62031482
123VEGF signaling pathway_Homo sapiens_hsa043700.61917907
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61759218
125Toxoplasmosis_Homo sapiens_hsa051450.59757805
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59394405
127Tight junction_Homo sapiens_hsa045300.58874656
128Fatty acid degradation_Homo sapiens_hsa000710.57236277
129Bile secretion_Homo sapiens_hsa049760.57104657
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.57093650
131Apoptosis_Homo sapiens_hsa042100.57086931
132HIF-1 signaling pathway_Homo sapiens_hsa040660.56747866
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56330712
134Circadian entrainment_Homo sapiens_hsa047130.55457927
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54846479
136Retinol metabolism_Homo sapiens_hsa008300.54631885
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54018452
138Acute myeloid leukemia_Homo sapiens_hsa052210.53612572
139Complement and coagulation cascades_Homo sapiens_hsa046100.51811775
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51602726
141Chemical carcinogenesis_Homo sapiens_hsa052040.51435737
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50454102
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49993063
144Fatty acid metabolism_Homo sapiens_hsa012120.49504659
145Platelet activation_Homo sapiens_hsa046110.49095742
146Glutamatergic synapse_Homo sapiens_hsa047240.48511859
147Tryptophan metabolism_Homo sapiens_hsa003800.48246809
148Regulation of autophagy_Homo sapiens_hsa041400.48042681
149Gap junction_Homo sapiens_hsa045400.47706582
150GABAergic synapse_Homo sapiens_hsa047270.47412807
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47141956
152Protein digestion and absorption_Homo sapiens_hsa049740.46413704
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46407286
154TNF signaling pathway_Homo sapiens_hsa046680.45941198
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45671288
156Melanogenesis_Homo sapiens_hsa049160.45051574
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40879888
158Glycerolipid metabolism_Homo sapiens_hsa005610.39125697
159Inositol phosphate metabolism_Homo sapiens_hsa005620.35905583
160* Metabolic pathways_Homo sapiens_hsa011000.34341428
161Long-term depression_Homo sapiens_hsa047300.34335994
162Salivary secretion_Homo sapiens_hsa049700.34108099
163Insulin secretion_Homo sapiens_hsa049110.33693655
164Calcium signaling pathway_Homo sapiens_hsa040200.33565957
165Dopaminergic synapse_Homo sapiens_hsa047280.33543521
166Fatty acid elongation_Homo sapiens_hsa000620.33373815
167Ovarian steroidogenesis_Homo sapiens_hsa049130.33054264
168Sphingolipid metabolism_Homo sapiens_hsa006000.32322305
169Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27594573

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