ALG13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.39659123
2synaptonemal complex assembly (GO:0007130)9.30596835
3male meiosis (GO:0007140)9.30366154
4meiosis I (GO:0007127)8.72481411
5synaptonemal complex organization (GO:0070193)8.45825617
6histone H3-K36 demethylation (GO:0070544)8.40601065
7meiotic nuclear division (GO:0007126)8.33854288
8DNA synthesis involved in DNA repair (GO:0000731)8.30842992
9histone H3-K9 demethylation (GO:0033169)7.63391553
10sister chromatid cohesion (GO:0007062)7.43332810
11regulation of meiosis I (GO:0060631)6.91188981
12meiotic cell cycle process (GO:1903046)6.13141063
13positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.95985723
14regulation of transcription from RNA polymerase I promoter (GO:0006356)5.78344187
15reciprocal meiotic recombination (GO:0007131)5.76001924
16reciprocal DNA recombination (GO:0035825)5.76001924
17negative regulation of gene silencing (GO:0060969)5.66822195
18regulation of DNA endoreduplication (GO:0032875)5.51524392
19growth hormone receptor signaling pathway (GO:0060396)5.36162983
20mitotic sister chromatid cohesion (GO:0007064)5.10587073
21positive regulation of response to oxidative stress (GO:1902884)5.06790237
22positive regulation of cellular response to oxidative stress (GO:1900409)5.06790237
23gene silencing by RNA (GO:0031047)4.85058832
24signal complex assembly (GO:0007172)4.83348942
25DNA replication initiation (GO:0006270)4.73641094
26cellular response to growth hormone stimulus (GO:0071378)4.71317948
27regulation of chromatin silencing (GO:0031935)4.69053903
28telomere maintenance via semi-conservative replication (GO:0032201)4.37045355
29DNA strand elongation involved in DNA replication (GO:0006271)4.36144775
30regulation of gene silencing by RNA (GO:0060966)4.34718195
31regulation of posttranscriptional gene silencing (GO:0060147)4.34718195
32regulation of gene silencing by miRNA (GO:0060964)4.34718195
33nuclear pore organization (GO:0006999)4.30856716
34regulation of helicase activity (GO:0051095)4.28615591
35DNA strand elongation (GO:0022616)4.18294830
36genitalia morphogenesis (GO:0035112)4.17848911
37embryonic body morphogenesis (GO:0010172)4.16884625
38histone H2A acetylation (GO:0043968)4.15187223
39DNA replication checkpoint (GO:0000076)4.12348429
40DNA methylation (GO:0006306)4.12082824
41DNA alkylation (GO:0006305)4.12082824
42mitotic metaphase plate congression (GO:0007080)4.11189458
43resolution of meiotic recombination intermediates (GO:0000712)4.10584572
44somatic hypermutation of immunoglobulin genes (GO:0016446)4.08742941
45somatic diversification of immune receptors via somatic mutation (GO:0002566)4.08742941
46nuclear pore complex assembly (GO:0051292)4.08604796
47histone H4-K16 acetylation (GO:0043984)4.05167314
48ribosome assembly (GO:0042255)4.03929253
49protein localization to kinetochore (GO:0034501)4.02632313
50regulation of nuclear cell cycle DNA replication (GO:0033262)4.01977262
51DNA replication-dependent nucleosome assembly (GO:0006335)4.00778574
52DNA replication-dependent nucleosome organization (GO:0034723)4.00778574
53protein K6-linked ubiquitination (GO:0085020)3.93015762
54telomere maintenance via recombination (GO:0000722)3.92066217
55establishment of nucleus localization (GO:0040023)3.91129676
56histone lysine demethylation (GO:0070076)3.85711269
57female gamete generation (GO:0007292)3.83699643
58interkinetic nuclear migration (GO:0022027)3.80581600
59kinetochore organization (GO:0051383)3.78287612
60nucleobase biosynthetic process (GO:0046112)3.77212408
61formation of translation preinitiation complex (GO:0001731)3.76919967
62kinetochore assembly (GO:0051382)3.76879475
63histone demethylation (GO:0016577)3.76783117
64histone H4-K8 acetylation (GO:0043982)3.75814521
65histone H4-K5 acetylation (GO:0043981)3.75814521
66DNA deamination (GO:0045006)3.74089148
67mitotic recombination (GO:0006312)3.72409234
68sex differentiation (GO:0007548)3.71182981
69telomere maintenance via telomere lengthening (GO:0010833)3.69920518
70metaphase plate congression (GO:0051310)3.68714967
71ribosome biogenesis (GO:0042254)3.67400333
72nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.66343690
73mitotic nuclear envelope disassembly (GO:0007077)3.66169606
74chromatin remodeling at centromere (GO:0031055)3.65773940
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.63730279
76maturation of SSU-rRNA (GO:0030490)3.63479148
77regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.58746582
78DNA unwinding involved in DNA replication (GO:0006268)3.57369969
79purine nucleobase biosynthetic process (GO:0009113)3.55612658
80protein localization to chromosome, centromeric region (GO:0071459)3.55301920
81positive regulation of meiosis (GO:0045836)3.53196555
82nucleus localization (GO:0051647)3.50762769
83CENP-A containing nucleosome assembly (GO:0034080)3.49841661
84mitotic sister chromatid segregation (GO:0000070)3.46606084
85replication fork processing (GO:0031297)3.40688808
86protein dealkylation (GO:0008214)3.38860404
87protein demethylation (GO:0006482)3.38860404
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.36622130
89membrane disassembly (GO:0030397)3.36130612
90nuclear envelope disassembly (GO:0051081)3.36130612
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.35025246
92ribonucleoprotein complex biogenesis (GO:0022613)3.33383713
93DNA replication-independent nucleosome organization (GO:0034724)3.32462052
94DNA replication-independent nucleosome assembly (GO:0006336)3.32462052
95IMP biosynthetic process (GO:0006188)3.30429346
96histone H4-K12 acetylation (GO:0043983)3.30257179
97folic acid-containing compound biosynthetic process (GO:0009396)3.30200977
98intra-S DNA damage checkpoint (GO:0031573)3.29832599
99positive regulation of meiotic cell cycle (GO:0051446)3.28484798
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28480860
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27720205
102monoubiquitinated protein deubiquitination (GO:0035520)3.26792946
103meiotic cell cycle (GO:0051321)3.26524608
104regulation of telomere maintenance via telomerase (GO:0032210)3.26216930
105meiotic chromosome segregation (GO:0045132)3.23329534
106body morphogenesis (GO:0010171)3.22174171
107regulation of histone H3-K9 methylation (GO:0051570)3.20966574
108DNA geometric change (GO:0032392)3.20399928
109regulation of mitotic sister chromatid separation (GO:0010965)3.20395062
110regulation of mitotic sister chromatid segregation (GO:0033047)3.20395062
111regulation of sister chromatid segregation (GO:0033045)3.20395062
112DNA duplex unwinding (GO:0032508)3.19419401
113ribosomal small subunit assembly (GO:0000028)3.19325107
114pore complex assembly (GO:0046931)3.18624501
115positive regulation of gene expression, epigenetic (GO:0045815)3.17718513
116establishment of chromosome localization (GO:0051303)3.17405395
117attachment of spindle microtubules to kinetochore (GO:0008608)3.16698724
118DNA methylation or demethylation (GO:0044728)3.13837531
119negative regulation of chromosome segregation (GO:0051985)3.13818761
120regulation of spindle organization (GO:0090224)3.13252033
121mismatch repair (GO:0006298)3.13163265
122chromosome organization (GO:0051276)3.10910771
123ribosomal large subunit biogenesis (GO:0042273)3.10586608
124histone exchange (GO:0043486)3.09873613
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09210007
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09210007
127positive regulation of mitotic sister chromatid separation (GO:1901970)3.09210007
128positive regulation of histone methylation (GO:0031062)3.05865847
129maturation of 5.8S rRNA (GO:0000460)3.04969924
130rRNA processing (GO:0006364)3.04746190
131telomere maintenance (GO:0000723)3.03422869
132heterochromatin organization (GO:0070828)3.02218088
133telomere organization (GO:0032200)3.01900581
134regulation of mitotic spindle organization (GO:0060236)3.01159366
135DNA biosynthetic process (GO:0071897)3.00985511
136negative regulation of mitotic sister chromatid separation (GO:2000816)3.00934754
137negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00934754
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00934754
139negative regulation of sister chromatid segregation (GO:0033046)3.00934754
140negative regulation of histone methylation (GO:0031061)3.00243379
141spindle checkpoint (GO:0031577)2.99544251
142sister chromatid segregation (GO:0000819)2.99022682
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98304999
144regulation of gene silencing (GO:0060968)2.97891395
145negative regulation of inclusion body assembly (GO:0090084)2.97403640
146spindle assembly checkpoint (GO:0071173)2.97189444
147regulation of RNA export from nucleus (GO:0046831)2.96907136
148rRNA metabolic process (GO:0016072)2.95298809
149transcription-coupled nucleotide-excision repair (GO:0006283)2.95031266
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94790718
151mitotic chromosome condensation (GO:0007076)2.93728428
152IMP metabolic process (GO:0046040)2.93715529
153determination of adult lifespan (GO:0008340)2.92982693
154positive regulation of chromosome segregation (GO:0051984)2.92921298
155mitotic spindle assembly checkpoint (GO:0007094)2.91897552
156mitotic spindle checkpoint (GO:0071174)2.91679045
157regulation of chromosome segregation (GO:0051983)2.90571520
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.90313968
159regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89191701
160gene silencing (GO:0016458)2.88999783
161pseudouridine synthesis (GO:0001522)2.88774474
162protein K11-linked deubiquitination (GO:0035871)2.88143590
163ribosomal small subunit biogenesis (GO:0042274)2.87434243
164regulation of centrosome cycle (GO:0046605)2.87067097
165protein localization to chromosome (GO:0034502)2.86098464
166regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84710924
167regulation of double-strand break repair (GO:2000779)2.84263787
168histone H4 acetylation (GO:0043967)2.83545425
169regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.78088502
170nuclear division (GO:0000280)2.77895644
171reproductive system development (GO:0061458)2.76542899
172synapsis (GO:0007129)12.0290934
173male meiosis I (GO:0007141)10.8526232
174chromosome organization involved in meiosis (GO:0070192)10.6157827
175piRNA metabolic process (GO:0034587)10.5313222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89388681
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13958286
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.88857916
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58743268
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11947662
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04332276
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93318514
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93318514
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93318514
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82637502
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80268873
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73588639
13FUS_26573619_Chip-Seq_HEK293_Human2.73002116
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64457279
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59397726
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58619339
17NANOG_18555785_ChIP-Seq_MESCs_Mouse2.42052364
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40959657
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39185106
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.36734880
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34064029
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31106138
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30296830
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.29191155
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27687538
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25178077
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24007476
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.21968376
29TAF15_26573619_Chip-Seq_HEK293_Human2.18390782
30EWS_26573619_Chip-Seq_HEK293_Human2.18212750
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16342590
32IGF1R_20145208_ChIP-Seq_DFB_Human2.15819902
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.14316015
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.14102740
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.11713008
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09340626
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09177890
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07767172
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.99730708
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98444026
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98048232
42ZNF274_21170338_ChIP-Seq_K562_Hela1.95179038
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95090544
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93734611
45XRN2_22483619_ChIP-Seq_HELA_Human1.93408073
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88312054
47RNF2_27304074_Chip-Seq_NSC_Mouse1.87220957
48* VDR_23849224_ChIP-Seq_CD4+_Human1.86987269
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86948371
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.86115596
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.81710951
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81025652
53VDR_22108803_ChIP-Seq_LS180_Human1.78478510
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77338866
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76759355
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.74180213
57ER_23166858_ChIP-Seq_MCF-7_Human1.74154725
58BCAT_22108803_ChIP-Seq_LS180_Human1.72954443
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.70622237
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68776683
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67062855
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.67020554
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64342952
64FOXP3_21729870_ChIP-Seq_TREG_Human1.62450917
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.61941033
66AR_21909140_ChIP-Seq_LNCAP_Human1.61797719
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60912154
68NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60388079
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60199129
70TTF2_22483619_ChIP-Seq_HELA_Human1.58497030
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58280822
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57962414
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.55512317
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53829949
75DCP1A_22483619_ChIP-Seq_HELA_Human1.50410127
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47231842
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46227682
78GABP_19822575_ChIP-Seq_HepG2_Human1.45253110
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.45223253
80STAT3_23295773_ChIP-Seq_U87_Human1.42729337
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41253730
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41158791
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38776534
84TP53_22573176_ChIP-Seq_HFKS_Human1.36353368
85ELK1_19687146_ChIP-ChIP_HELA_Human1.33126318
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32819357
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32510661
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31762759
89TCF4_23295773_ChIP-Seq_U87_Human1.31582265
90P300_19829295_ChIP-Seq_ESCs_Human1.31535844
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31095016
92MYC_18940864_ChIP-ChIP_HL60_Human1.30484880
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29915300
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29861575
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29687049
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29115139
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26247289
98GATA3_26560356_Chip-Seq_TH1_Human1.26140216
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23664684
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23367747
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23284758
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22950171
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22907893
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22154602
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21060333
106KDM5A_27292631_Chip-Seq_BREAST_Human1.19807376
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19332388
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18640729
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17576493
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.17556021
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17361261
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17326672
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17259507
114MYC_22102868_ChIP-Seq_BL_Human1.16761518
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16472508
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15193996
117SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14877962
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13118097
119CIITA_25753668_ChIP-Seq_RAJI_Human1.12680620
120* RUNX2_22187159_ChIP-Seq_PCA_Human1.12663730
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11676233
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11358561
123AR_25329375_ChIP-Seq_VCAP_Human1.11278738
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11246251
125CDX2_22108803_ChIP-Seq_LS180_Human1.07016792
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06740705
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05899642
128TP53_16413492_ChIP-PET_HCT116_Human1.05779011
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05175634
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05146572
131CBP_20019798_ChIP-Seq_JUKART_Human1.05146572
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05041001
133ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04631812
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.04367470
135TFEB_21752829_ChIP-Seq_HELA_Human1.03213132
136OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02829705
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.02795239
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02042195
139NOTCH1_21737748_ChIP-Seq_TLL_Human1.01998004
140NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01697563
141CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01195234
142NFE2_27457419_Chip-Seq_LIVER_Mouse1.00638614
143SMAD4_21799915_ChIP-Seq_A2780_Human0.99488111
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98325142
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97504378
146* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97227040
147* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97212650
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96363404
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.96363404
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.94840539
151ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94162770
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.93522436
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93126260
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.93047082
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92716832
156TCF4_22108803_ChIP-Seq_LS180_Human0.92170917
157RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91874808
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91537768
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.91461279
160ETV1_20927104_ChIP-Seq_GIST48_Human0.91003636
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90825656
162HTT_18923047_ChIP-ChIP_STHdh_Human0.90608063
163E2F1_18555785_Chip-Seq_ESCs_Mouse0.90434646
164IRF1_19129219_ChIP-ChIP_H3396_Human0.90202005
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89961734
166POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89279093
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.89231360
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88863607
169SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88081943
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87255753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74219077
2MP0010094_abnormal_chromosome_stability4.54364100
3MP0008057_abnormal_DNA_replication4.47063820
4MP0003111_abnormal_nucleus_morphology4.24171827
5MP0004957_abnormal_blastocyst_morpholog4.11867014
6MP0003077_abnormal_cell_cycle3.69157574
7MP0008058_abnormal_DNA_repair3.59265360
8MP0000383_abnormal_hair_follicle3.11265448
9MP0000569_abnormal_digit_pigmentation2.81725074
10MP0006292_abnormal_olfactory_placode2.77754645
11MP0003136_yellow_coat_color2.68892717
12MP0008007_abnormal_cellular_replicative2.50351818
13MP0010678_abnormal_skin_adnexa2.41617191
14MP0003646_muscle_fatigue2.37653631
15MP0000427_abnormal_hair_cycle2.35197102
16MP0008932_abnormal_embryonic_tissue2.34555473
17MP0003786_premature_aging2.31408566
18MP0003718_maternal_effect2.23505037
19MP0000350_abnormal_cell_proliferation2.16769556
20MP0008877_abnormal_DNA_methylation2.10993471
21MP0005409_darkened_coat_color2.09137601
22MP0003806_abnormal_nucleotide_metabolis2.04450924
23MP0004133_heterotaxia2.03787390
24MP0010352_gastrointestinal_tract_polyps2.02205295
25MP0002653_abnormal_ependyma_morphology1.98448272
26MP0001730_embryonic_growth_arrest1.92257260
27MP0003123_paternal_imprinting1.84771557
28MP0010307_abnormal_tumor_latency1.82466669
29MP0002009_preneoplasia1.76789595
30MP0000490_abnormal_crypts_of1.74243327
31MP0001672_abnormal_embryogenesis/_devel1.72423983
32MP0005380_embryogenesis_phenotype1.72423983
33MP0003943_abnormal_hepatobiliary_system1.72011627
34MP0002085_abnormal_embryonic_tissue1.71949153
35MP0002396_abnormal_hematopoietic_system1.71914845
36MP0000678_abnormal_parathyroid_gland1.70894645
37* MP0002084_abnormal_developmental_patter1.62193598
38MP0003890_abnormal_embryonic-extraembry1.61969407
39MP0001697_abnormal_embryo_size1.61348989
40MP0002210_abnormal_sex_determination1.59461073
41MP0003941_abnormal_skin_development1.58593442
42MP0001293_anophthalmia1.56148894
43MP0008004_abnormal_stomach_pH1.54279182
44MP0001661_extended_life_span1.46495461
45MP0002086_abnormal_extraembryonic_tissu1.44060487
46MP0004197_abnormal_fetal_growth/weight/1.42784010
47MP0003984_embryonic_growth_retardation1.41479214
48MP0001145_abnormal_male_reproductive1.39864363
49* MP0002080_prenatal_lethality1.38570607
50MP0002088_abnormal_embryonic_growth/wei1.38302757
51MP0006035_abnormal_mitochondrial_morpho1.36001235
52MP0000313_abnormal_cell_death1.33272955
53MP0003119_abnormal_digestive_system1.32478052
54MP0003567_abnormal_fetal_cardiomyocyte1.32337163
55MP0005075_abnormal_melanosome_morpholog1.30214565
56MP0003315_abnormal_perineum_morphology1.29996770
57MP0002019_abnormal_tumor_incidence1.28634183
58MP0001929_abnormal_gametogenesis1.26591765
59MP0010030_abnormal_orbit_morphology1.25045705
60MP0003121_genomic_imprinting1.23033242
61MP0005310_abnormal_salivary_gland1.19530896
62MP0000653_abnormal_sex_gland1.19503985
63MP0003283_abnormal_digestive_organ1.07737320
64MP0005174_abnormal_tail_pigmentation1.04442906
65MP0004264_abnormal_extraembryonic_tissu1.04403013
66MP0001119_abnormal_female_reproductive1.03841951
67MP0003937_abnormal_limbs/digits/tail_de1.03685868
68MP0005076_abnormal_cell_differentiation0.99561138
69MP0002249_abnormal_larynx_morphology0.99509936
70MP0000371_diluted_coat_color0.98001881
71MP0000013_abnormal_adipose_tissue0.97992214
72MP0002160_abnormal_reproductive_system0.97314905
73MP0001188_hyperpigmentation0.97298228
74MP0002075_abnormal_coat/hair_pigmentati0.95274588
75MP0005389_reproductive_system_phenotype0.95206783
76MP0005397_hematopoietic_system_phenotyp0.94393940
77MP0001545_abnormal_hematopoietic_system0.94393940
78MP0003453_abnormal_keratinocyte_physiol0.90841350
79MP0000647_abnormal_sebaceous_gland0.90583561
80MP0009697_abnormal_copulation0.90005061
81MP0002111_abnormal_tail_morphology0.89431939
82MP0001243_abnormal_dermal_layer0.87633867
83MP0001286_abnormal_eye_development0.86260330
84MP0001919_abnormal_reproductive_system0.85913277
85MP0009333_abnormal_splenocyte_physiolog0.84431065
86MP0002277_abnormal_respiratory_mucosa0.84080576
87MP0009053_abnormal_anal_canal0.82936023
88MP0000049_abnormal_middle_ear0.82720204
89MP0001915_intracranial_hemorrhage0.81591789
90MP0001764_abnormal_homeostasis0.81399761
91MP0002166_altered_tumor_susceptibility0.81003253
92MP0008995_early_reproductive_senescence0.78361932
93MP0000537_abnormal_urethra_morphology0.78264120
94MP0000015_abnormal_ear_pigmentation0.78247944
95MP0001186_pigmentation_phenotype0.77608498
96MP0003936_abnormal_reproductive_system0.76701214
97MP0000432_abnormal_head_morphology0.74861889
98MP0003698_abnormal_male_reproductive0.74845699
99MP0001984_abnormal_olfaction0.74232673
100MP0003763_abnormal_thymus_physiology0.73642906
101MP0003938_abnormal_ear_development0.73383195
102MP0005266_abnormal_metabolism0.72233971
103MP0003699_abnormal_female_reproductive0.70554759
104MP0008260_abnormal_autophagy0.70363631
105MP0002092_abnormal_eye_morphology0.68909854
106MP0003186_abnormal_redox_activity0.68133886
107MP0004808_abnormal_hematopoietic_stem0.68028945
108MP0000358_abnormal_cell_content/0.67779675
109MP0005395_other_phenotype0.67704305
110MP0009379_abnormal_foot_pigmentation0.66326330
111MP0000703_abnormal_thymus_morphology0.65735754
112MP0002751_abnormal_autonomic_nervous0.65422853
113MP0003115_abnormal_respiratory_system0.65120006
114MP0009703_decreased_birth_body0.64590343
115MP0005384_cellular_phenotype0.64488288
116MP0002006_tumorigenesis0.64315408
117MP0000477_abnormal_intestine_morphology0.64296530
118MP0002095_abnormal_skin_pigmentation0.63733136
119MP0002938_white_spotting0.63370608
120MP0000858_altered_metastatic_potential0.63098770
121MP0000689_abnormal_spleen_morphology0.63051330
122MP0002722_abnormal_immune_system0.61457403
123MP0002161_abnormal_fertility/fecundity0.61275937
124MP0002928_abnormal_bile_duct0.60089448
125MP0009278_abnormal_bone_marrow0.60087955
126MP0005410_abnormal_fertilization0.55785943
127MP0001191_abnormal_skin_condition0.55411930
128MP0001542_abnormal_bone_strength0.54631984
129MP0005645_abnormal_hypothalamus_physiol0.54115231
130MP0001800_abnormal_humoral_immune0.52981851
131MP0002398_abnormal_bone_marrow0.52415561
132MP0001835_abnormal_antigen_presentation0.49011870
133MP0005647_abnormal_sex_gland0.48544811
134MP0004036_abnormal_muscle_relaxation0.47475442
135MP0001216_abnormal_epidermal_layer0.45832578
136MP0003172_abnormal_lysosome_physiology0.44108292
137MP0000372_irregular_coat_pigmentation0.42671401
138MP0002971_abnormal_brown_adipose0.40612526

Predicted human phenotypes

RankGene SetZ-score
1Amyotrophic lateral sclerosis (HP:0007354)5.04535645
2Gonadotropin excess (HP:0000837)5.04381904
3Chromsome breakage (HP:0040012)4.93973093
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.93459823
5Shoulder girdle muscle weakness (HP:0003547)4.54268001
6Ependymoma (HP:0002888)4.36266079
7Abnormality of the lower motor neuron (HP:0002366)4.32720011
8Oligodactyly (hands) (HP:0001180)4.26656999
9Rimmed vacuoles (HP:0003805)4.23216808
10Birth length less than 3rd percentile (HP:0003561)4.07240454
11Tubulointerstitial nephritis (HP:0001970)3.87370565
12Medulloblastoma (HP:0002885)3.82088816
13Supernumerary spleens (HP:0009799)3.81031473
14Breast hypoplasia (HP:0003187)3.73242701
15Abnormality of chromosome stability (HP:0003220)3.59808493
16Meckel diverticulum (HP:0002245)3.54093693
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.49815841
18Abnormality of the ileum (HP:0001549)3.46972802
19Atrophy/Degeneration involving motor neurons (HP:0007373)3.46161981
20Agnosia (HP:0010524)3.45853091
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.43754026
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.43754026
23Upper motor neuron abnormality (HP:0002127)3.43380279
24Absent radius (HP:0003974)3.39265967
25Abnormality of the preputium (HP:0100587)3.35041975
26Large hands (HP:0001176)3.34056877
27Impulsivity (HP:0100710)3.31154927
28Reticulocytopenia (HP:0001896)3.27666590
29Abnormality of the labia minora (HP:0012880)3.26734986
30Lip pit (HP:0100267)3.22879273
31Selective tooth agenesis (HP:0001592)3.21285855
32Aplasia involving forearm bones (HP:0009822)3.17269863
33Absent forearm bone (HP:0003953)3.17269863
34Rhabdomyosarcoma (HP:0002859)3.13786202
35Patellar aplasia (HP:0006443)3.11063885
36Azoospermia (HP:0000027)3.10744521
37Colon cancer (HP:0003003)3.08848893
38Neoplasm of the oral cavity (HP:0100649)3.06025321
39Aplasia/hypoplasia of the humerus (HP:0006507)3.03957197
40Hypoplastic iliac wings (HP:0002866)3.02382751
41Absent thumb (HP:0009777)3.02047482
42Abnormality of the astrocytes (HP:0100707)2.95379618
43Astrocytoma (HP:0009592)2.95379618
44Widely spaced teeth (HP:0000687)2.91513198
45Osteomalacia (HP:0002749)2.90201379
46Aplasia/Hypoplasia of the patella (HP:0006498)2.88934414
47Rib fusion (HP:0000902)2.84315688
48Duodenal stenosis (HP:0100867)2.77525615
49Small intestinal stenosis (HP:0012848)2.77525615
50Carpal bone hypoplasia (HP:0001498)2.76488200
51Short humerus (HP:0005792)2.75713345
52Oral leukoplakia (HP:0002745)2.74776643
53Glioma (HP:0009733)2.73391972
54Oligodactyly (HP:0012165)2.68761005
55Increased nuchal translucency (HP:0010880)2.66643332
56Myelodysplasia (HP:0002863)2.66116320
57Non-midline cleft lip (HP:0100335)2.64456976
58Abnormality of the renal medulla (HP:0100957)2.62550057
59Truncal obesity (HP:0001956)2.60807607
60Menstrual irregularities (HP:0000858)2.59393130
61Abnormality of cochlea (HP:0000375)2.57011170
62Spontaneous abortion (HP:0005268)2.56189701
63Abnormal spermatogenesis (HP:0008669)2.54159614
64Abnormality of chromosome segregation (HP:0002916)2.53969621
65Nephronophthisis (HP:0000090)2.50678379
66Metaphyseal cupping (HP:0003021)2.47382488
67Abnormality of the corticospinal tract (HP:0002492)2.44723609
68Rough bone trabeculation (HP:0100670)2.44518771
69Abnormality of cells of the erythroid lineage (HP:0012130)2.43872809
70Neoplasm of striated muscle (HP:0009728)2.43595941
71Hyperkalemia (HP:0002153)2.43041620
72Synophrys (HP:0000664)2.42156199
73Abnormality of the duodenum (HP:0002246)2.41822262
74Bone marrow hypocellularity (HP:0005528)2.41356344
75Abdominal situs inversus (HP:0003363)2.41132603
76Abnormality of abdominal situs (HP:0011620)2.41132603
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39843924
78Nephroblastoma (Wilms tumor) (HP:0002667)2.39674570
79Sloping forehead (HP:0000340)2.39454172
80Aplastic anemia (HP:0001915)2.39168052
81Broad distal phalanx of finger (HP:0009836)2.39088060
82Papillary thyroid carcinoma (HP:0002895)2.37603514
83Abnormality of the anterior horn cell (HP:0006802)2.37081231
84Degeneration of anterior horn cells (HP:0002398)2.37081231
85Short nail (HP:0001799)2.34441646
86Rectal fistula (HP:0100590)2.34110087
87Rectovaginal fistula (HP:0000143)2.34110087
88Duplicated collecting system (HP:0000081)2.33116059
89Tracheoesophageal fistula (HP:0002575)2.32878850
90Ectopic kidney (HP:0000086)2.30415524
91Bicuspid aortic valve (HP:0001647)2.30219000
92Triphalangeal thumb (HP:0001199)2.30020055
93Premature graying of hair (HP:0002216)2.29948016
94Shawl scrotum (HP:0000049)2.29554275
95Reduced antithrombin III activity (HP:0001976)2.27522083
96Short thumb (HP:0009778)2.25923781
97Abnormal number of incisors (HP:0011064)2.25560632
98Clubbing of toes (HP:0100760)2.23848848
99Amaurosis fugax (HP:0100576)2.22558750
100Abnormal number of erythroid precursors (HP:0012131)2.19899584
101Aplasia/Hypoplasia of the sternum (HP:0006714)2.18404531
102Embryonal renal neoplasm (HP:0011794)2.17789582
103Sex reversal (HP:0012245)2.15420010
104Abnormal sex determination (HP:0012244)2.15420010
105Missing ribs (HP:0000921)2.15350260
106Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15259491
107Medial flaring of the eyebrow (HP:0010747)2.12648418
108Poor coordination (HP:0002370)2.11799512
109Multicystic kidney dysplasia (HP:0000003)2.10628391
110Abnormal lung lobation (HP:0002101)2.10514318
111Intestinal fistula (HP:0100819)2.10311223
112Abnormality of the renal collecting system (HP:0004742)2.09973925
113* Type I transferrin isoform profile (HP:0003642)2.08885392
114Preaxial hand polydactyly (HP:0001177)2.07897371
115Neoplasm of the pancreas (HP:0002894)2.07305858
116Abnormality of chloride homeostasis (HP:0011422)2.07248256
117Congenital primary aphakia (HP:0007707)2.06979246
118Basal cell carcinoma (HP:0002671)2.05160751
119Premature ovarian failure (HP:0008209)2.05011725
120Abnormality of the carotid arteries (HP:0005344)2.04781700
121Facial hemangioma (HP:0000329)2.04588323
122Horseshoe kidney (HP:0000085)2.03831092
123Asplenia (HP:0001746)2.02613099
12411 pairs of ribs (HP:0000878)2.01638080
125Fair hair (HP:0002286)1.99084976
126Volvulus (HP:0002580)1.98960513
127Microvesicular hepatic steatosis (HP:0001414)1.98107876
128Low posterior hairline (HP:0002162)1.97752246
129Hypoplasia of the radius (HP:0002984)1.97577758
130Impaired vibration sensation in the lower limbs (HP:0002166)1.95918997
131Proximal placement of thumb (HP:0009623)1.93834590
132Abnormality of DNA repair (HP:0003254)1.93726169
133Intestinal atresia (HP:0011100)1.93554104
134Abnormality of the renal cortex (HP:0011035)1.92823670
135Gait imbalance (HP:0002141)1.90992452
136Cutaneous melanoma (HP:0012056)1.89139137
137Hypoplastic labia majora (HP:0000059)1.88818791
138Abnormality of the salivary glands (HP:0010286)1.88483867
139Esophageal atresia (HP:0002032)1.88399260
140Supernumerary bones of the axial skeleton (HP:0009144)1.88277937
141Abnormality of the vocal cords (HP:0008777)1.87535937
142Fused cervical vertebrae (HP:0002949)1.86655926
143Scotoma (HP:0000575)1.86054834
144High anterior hairline (HP:0009890)1.84567920
145Nephrogenic diabetes insipidus (HP:0009806)1.84554303
146Deep philtrum (HP:0002002)1.84240057
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.81239057
148Deviation of the thumb (HP:0009603)1.80762548
149Cleft eyelid (HP:0000625)1.80557919
150Vertebral arch anomaly (HP:0008438)1.80516577
151Vaginal fistula (HP:0004320)1.78663579
152Abnormality of pyrimidine metabolism (HP:0004353)1.78124540
153Septo-optic dysplasia (HP:0100842)1.77936297
154Astigmatism (HP:0000483)1.77697596
155Gastrointestinal atresia (HP:0002589)1.77692602
156Capillary hemangiomas (HP:0005306)1.76840283
157Chronic diarrhea (HP:0002028)1.76602346
158Wide intermamillary distance (HP:0006610)1.75219342
159Abnormality of the fingertips (HP:0001211)1.69795625
160Resting tremor (HP:0002322)1.66475985
161Abnormality of the labia majora (HP:0012881)1.66384048
162Neoplasm of the colon (HP:0100273)1.66148342
163Abnormality of permanent molar morphology (HP:0011071)1.65495172
164Abnormality of the dental root (HP:0006486)1.65495172
165Taurodontia (HP:0000679)1.65495172
166Abnormality of the motor neurons (HP:0002450)1.64916417
167Abnormal neuron morphology (HP:0012757)1.64916417
168Absent speech (HP:0001344)1.64646422
169Intellectual disability, moderate (HP:0002342)1.64540580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.28646289
2WEE14.62734815
3CAMK1G3.88653244
4CDC73.76204502
5CDK193.74072632
6BUB13.63251304
7PTK2B3.42138289
8BMX3.37867271
9CDK123.35153349
10FGR3.28592199
11CSF1R3.03623497
12TTK2.99965041
13EIF2AK32.85525395
14SRPK12.71504690
15NEK22.59393532
16MKNK22.44585372
17EPHA22.38297507
18CDK72.22211595
19PLK12.21903084
20PLK42.18902304
21ACVR1B2.06122656
22MKNK12.05195794
23NME22.01118073
24CHEK21.96473085
25RPS6KB21.93666732
26NEK11.89675526
27OXSR11.88738333
28ATR1.76015416
29DYRK31.74224240
30PLK21.74171595
31EIF2AK11.73210772
32TSSK61.68051413
33BRSK21.67629494
34PDGFRB1.64761795
35AKT31.63619774
36TLK11.62902068
37AURKB1.54765534
38STK161.50930824
39PASK1.50300616
40RET1.46771503
41CASK1.46455580
42VRK11.45368417
43CDK41.40962878
44PLK31.34871035
45ZAK1.32857906
46MST41.31353721
47AURKA1.29080448
48CHEK11.27406439
49BRD41.26894659
50NUAK11.23341458
51FRK1.22156079
52MAP3K101.19904337
53FLT31.11360475
54PIM11.10983733
55NLK1.10549804
56ATM1.10236074
57STK38L1.07416681
58EIF2AK21.05159797
59MAP3K81.01960505
60CDK20.97069167
61TNIK0.95465855
62YES10.95096155
63EGFR0.92218656
64TAF10.85131442
65STK40.83637654
66BCKDK0.82040541
67RPS6KA40.81390937
68PRKCI0.80862600
69MAPKAPK30.78935611
70PNCK0.78723559
71NEK90.78136392
72MST1R0.77906661
73STK100.75631997
74BRAF0.74980055
75MUSK0.74211878
76CSNK2A20.73757838
77MAP3K40.72904873
78TESK20.71422480
79PTK20.71389187
80TGFBR10.70867681
81CSNK2A10.69686811
82MAP3K60.68915968
83CDK10.68833720
84TAOK20.68546985
85BRSK10.66282334
86LATS20.64888976
87DYRK20.64729702
88CDK60.63267956
89PAK40.62767402
90CDK80.60016720
91TXK0.57439404
92TEC0.57424119
93MATK0.56638231
94SCYL20.55747041
95RPS6KB10.55497280
96STK30.53292702
97MAP3K20.52970866
98PAK10.51287248
99MAPK130.50843818
100ALK0.50729041
101SGK10.50408417
102IRAK30.47691217
103EEF2K0.46648240
104PBK0.46405992
105IKBKB0.45839928
106NEK60.45796464
107MELK0.45753649
108CSNK1D0.44562133
109TAOK30.43948199
110MTOR0.43018337
111RPS6KA50.42502132
112LATS10.41788718
113STK110.41756811
114CAMK10.41113254
115ICK0.41109207
116PIM20.41022993
117WNK10.40078694
118MARK30.38730599
119CSNK1E0.38401269
120PRKDC0.37210236
121AKT20.36617594
122MAPK140.36353732
123CCNB10.36075727
124MAP4K20.34687422
125CDK30.33710129
126MAP3K90.33685920
127IRAK40.33523801
128CDK90.33193442
129STK380.33167509
130IGF1R0.32813012
131TRIM280.32600441
132MAP3K130.31609377
133PINK10.30804604
134MAP3K110.30711569
135ERBB40.30627004
136AKT10.30603219
137DYRK1A0.30078081
138CLK10.29892795
139MAPK70.29719692
140MAPK10.29508875
141GSK3B0.28651278
142PDK20.28452040
143ROCK10.28384304
144CSNK1G10.27119343
145BMPR1B0.26265461
146MAP2K20.25170213
147KSR10.23610489
148CHUK0.22454772
149ERBB30.21121763
150FGFR30.21069256
151ITK0.19306885
152SGK20.17346349
153RAF10.17172736
154STK240.16007493
155MAP3K50.15759834
156PRKCE0.14731429

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91952553
2Mismatch repair_Homo sapiens_hsa034304.60098527
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92705521
4Homologous recombination_Homo sapiens_hsa034403.42623909
5Base excision repair_Homo sapiens_hsa034103.21269219
6Spliceosome_Homo sapiens_hsa030403.14301342
7RNA transport_Homo sapiens_hsa030133.13429083
8RNA polymerase_Homo sapiens_hsa030203.10800638
9Ribosome_Homo sapiens_hsa030103.04221549
10Fanconi anemia pathway_Homo sapiens_hsa034602.99649449
11Nucleotide excision repair_Homo sapiens_hsa034202.95813840
12One carbon pool by folate_Homo sapiens_hsa006702.64855023
13Cell cycle_Homo sapiens_hsa041102.64445235
14Pyrimidine metabolism_Homo sapiens_hsa002402.29570745
15Basal transcription factors_Homo sapiens_hsa030222.29486469
16Proteasome_Homo sapiens_hsa030502.28772120
17Non-homologous end-joining_Homo sapiens_hsa034502.23374117
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20628614
19RNA degradation_Homo sapiens_hsa030182.06889458
20mRNA surveillance pathway_Homo sapiens_hsa030151.80938066
21p53 signaling pathway_Homo sapiens_hsa041151.78123774
22Lysine degradation_Homo sapiens_hsa003101.59487597
23Dorso-ventral axis formation_Homo sapiens_hsa043201.37865040
24ErbB signaling pathway_Homo sapiens_hsa040121.35805900
25Purine metabolism_Homo sapiens_hsa002301.27833996
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22521310
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21364192
28Folate biosynthesis_Homo sapiens_hsa007901.13181569
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07607661
30Propanoate metabolism_Homo sapiens_hsa006401.03425147
31Herpes simplex infection_Homo sapiens_hsa051681.03112971
32Epstein-Barr virus infection_Homo sapiens_hsa051691.01340775
33Vitamin B6 metabolism_Homo sapiens_hsa007500.97479882
34Systemic lupus erythematosus_Homo sapiens_hsa053220.97058893
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96321637
36Choline metabolism in cancer_Homo sapiens_hsa052310.95372305
37Thyroid cancer_Homo sapiens_hsa052160.91337938
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90602350
39T cell receptor signaling pathway_Homo sapiens_hsa046600.90588489
40Oocyte meiosis_Homo sapiens_hsa041140.80884320
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79613694
42Viral carcinogenesis_Homo sapiens_hsa052030.78671264
43Ether lipid metabolism_Homo sapiens_hsa005650.76877174
44Retinol metabolism_Homo sapiens_hsa008300.75704636
45Basal cell carcinoma_Homo sapiens_hsa052170.71405038
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71056728
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70904691
48MicroRNAs in cancer_Homo sapiens_hsa052060.65405452
49Antigen processing and presentation_Homo sapiens_hsa046120.64797335
50TGF-beta signaling pathway_Homo sapiens_hsa043500.63066361
51VEGF signaling pathway_Homo sapiens_hsa043700.62802137
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.62771992
53Selenocompound metabolism_Homo sapiens_hsa004500.61466721
54HTLV-I infection_Homo sapiens_hsa051660.61226769
55Notch signaling pathway_Homo sapiens_hsa043300.60644107
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60455692
57Hippo signaling pathway_Homo sapiens_hsa043900.59520473
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58914051
59Pentose phosphate pathway_Homo sapiens_hsa000300.58879417
60Sulfur relay system_Homo sapiens_hsa041220.58849476
61Biosynthesis of amino acids_Homo sapiens_hsa012300.58643657
62ABC transporters_Homo sapiens_hsa020100.53650021
63Circadian rhythm_Homo sapiens_hsa047100.53398983
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.52397616
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.52094556
66Fructose and mannose metabolism_Homo sapiens_hsa000510.49830166
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49127501
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.48847671
69Glutathione metabolism_Homo sapiens_hsa004800.48378893
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.47676573
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46072520
72Chronic myeloid leukemia_Homo sapiens_hsa052200.45007407
73FoxO signaling pathway_Homo sapiens_hsa040680.44287165
74Arachidonic acid metabolism_Homo sapiens_hsa005900.43339950
75Regulation of autophagy_Homo sapiens_hsa041400.43167031
76Colorectal cancer_Homo sapiens_hsa052100.42666909
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42438375
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41802386
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40323176
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.40153982
81Type I diabetes mellitus_Homo sapiens_hsa049400.39862010
82B cell receptor signaling pathway_Homo sapiens_hsa046620.39705965
83Legionellosis_Homo sapiens_hsa051340.39477841
84Primary immunodeficiency_Homo sapiens_hsa053400.38111799
85MAPK signaling pathway_Homo sapiens_hsa040100.37808912
86Hedgehog signaling pathway_Homo sapiens_hsa043400.37293944
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37250282
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37171371
89Peroxisome_Homo sapiens_hsa041460.36035017
90Small cell lung cancer_Homo sapiens_hsa052220.34898154
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34652563
92Protein export_Homo sapiens_hsa030600.34496508
93Adherens junction_Homo sapiens_hsa045200.34132218
94Inositol phosphate metabolism_Homo sapiens_hsa005620.32830560
95Viral myocarditis_Homo sapiens_hsa054160.32768633
96Apoptosis_Homo sapiens_hsa042100.31895124
97Pathways in cancer_Homo sapiens_hsa052000.31633960
98Wnt signaling pathway_Homo sapiens_hsa043100.31296179
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30417043
100Linoleic acid metabolism_Homo sapiens_hsa005910.29813051
101Other glycan degradation_Homo sapiens_hsa005110.29665409
102Alcoholism_Homo sapiens_hsa050340.27801141
103Measles_Homo sapiens_hsa051620.27525377
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27046541
105Galactose metabolism_Homo sapiens_hsa000520.26886250
106Type II diabetes mellitus_Homo sapiens_hsa049300.26663339
107Non-small cell lung cancer_Homo sapiens_hsa052230.26134910
108Pancreatic cancer_Homo sapiens_hsa052120.26064526
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25872123
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25580647
111Acute myeloid leukemia_Homo sapiens_hsa052210.25568673
112Amoebiasis_Homo sapiens_hsa051460.25229245
113Graft-versus-host disease_Homo sapiens_hsa053320.25059772
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24758335
115Asthma_Homo sapiens_hsa053100.24705042
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24347823
117Prolactin signaling pathway_Homo sapiens_hsa049170.24067131
118Chemokine signaling pathway_Homo sapiens_hsa040620.23438437
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23422910
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23120298
121Autoimmune thyroid disease_Homo sapiens_hsa053200.22709221
122Allograft rejection_Homo sapiens_hsa053300.22631622
123Influenza A_Homo sapiens_hsa051640.22474630
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.21675983
125mTOR signaling pathway_Homo sapiens_hsa041500.21581220
126Prostate cancer_Homo sapiens_hsa052150.21174535
127Arginine and proline metabolism_Homo sapiens_hsa003300.19671749
128Hematopoietic cell lineage_Homo sapiens_hsa046400.19410531
129Bladder cancer_Homo sapiens_hsa052190.18755714
130Hepatitis B_Homo sapiens_hsa051610.18351786
131* Metabolic pathways_Homo sapiens_hsa011000.16393077
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15553327
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15273211
134Huntingtons disease_Homo sapiens_hsa050160.13688177
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13642372
136HIF-1 signaling pathway_Homo sapiens_hsa040660.12986452
137Shigellosis_Homo sapiens_hsa051310.12515998
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11572159
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11128591
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.10344263
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.10095202

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