ALG14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleotide transmembrane transport (GO:1901679)5.90749930
2behavioral response to nicotine (GO:0035095)5.42610966
3protein neddylation (GO:0045116)5.31972369
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94310211
5signal peptide processing (GO:0006465)4.87790110
6proteasome assembly (GO:0043248)4.71589646
7cullin deneddylation (GO:0010388)4.48001432
8sulfation (GO:0051923)4.45402455
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42710034
10ATP synthesis coupled proton transport (GO:0015986)4.42710034
11peptidyl-histidine modification (GO:0018202)4.38788764
12tryptophan catabolic process (GO:0006569)4.32251864
13indole-containing compound catabolic process (GO:0042436)4.32251864
14indolalkylamine catabolic process (GO:0046218)4.32251864
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31358042
16indolalkylamine metabolic process (GO:0006586)4.22508242
17water-soluble vitamin biosynthetic process (GO:0042364)4.20428342
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14080512
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.14080512
20NADH dehydrogenase complex assembly (GO:0010257)4.14080512
21respiratory chain complex IV assembly (GO:0008535)4.11258601
22protein complex biogenesis (GO:0070271)4.09608997
23regulation of metalloenzyme activity (GO:0048552)4.07272785
24protein deneddylation (GO:0000338)4.04148241
25tryptophan metabolic process (GO:0006568)4.03889294
26kynurenine metabolic process (GO:0070189)3.93600542
27respiratory electron transport chain (GO:0022904)3.88137280
28fucose catabolic process (GO:0019317)3.84745546
29L-fucose metabolic process (GO:0042354)3.84745546
30L-fucose catabolic process (GO:0042355)3.84745546
31electron transport chain (GO:0022900)3.77653651
32cytochrome complex assembly (GO:0017004)3.74407874
33aldehyde catabolic process (GO:0046185)3.73378176
34purine ribonucleotide transport (GO:0015868)3.70360028
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.68773783
36termination of RNA polymerase III transcription (GO:0006386)3.68773783
37nucleotide transport (GO:0006862)3.58841906
38chaperone-mediated protein transport (GO:0072321)3.52627209
39mitochondrial respiratory chain complex assembly (GO:0033108)3.52013663
40uronic acid metabolic process (GO:0006063)3.49175264
41glucuronate metabolic process (GO:0019585)3.49175264
42cell proliferation in forebrain (GO:0021846)3.48837746
43extracellular fibril organization (GO:0043206)3.46318651
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46285241
45indole-containing compound metabolic process (GO:0042430)3.41328701
46regulation of cellular amino acid metabolic process (GO:0006521)3.40871662
477-methylguanosine RNA capping (GO:0009452)3.35790584
48RNA capping (GO:0036260)3.35790584
497-methylguanosine mRNA capping (GO:0006370)3.33363563
50negative regulation of systemic arterial blood pressure (GO:0003085)3.29772242
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28795117
52GTP biosynthetic process (GO:0006183)3.27651296
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25014303
54serotonin metabolic process (GO:0042428)3.21927940
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21793210
562-deoxyribonucleotide biosynthetic process (GO:0009265)3.21519237
57deoxyribose phosphate biosynthetic process (GO:0046385)3.21519237
58guanosine-containing compound biosynthetic process (GO:1901070)3.20953502
59nucleotide-sugar biosynthetic process (GO:0009226)3.20244711
60purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.18592082
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.18592082
62ribosomal small subunit assembly (GO:0000028)3.15933490
63cellular glucuronidation (GO:0052695)3.15655250
64cellular response to ATP (GO:0071318)3.14034060
65gamma-aminobutyric acid transport (GO:0015812)3.14014656
66response to pheromone (GO:0019236)3.12787485
67primary amino compound metabolic process (GO:1901160)3.12166182
68mannosylation (GO:0097502)3.07231193
69negative regulation of ligase activity (GO:0051352)3.07076787
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07076787
71preassembly of GPI anchor in ER membrane (GO:0016254)3.05127693
72DNA deamination (GO:0045006)3.04480042
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99003834
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98443273
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98142840
76response to redox state (GO:0051775)2.97749940
77negative regulation of transcription regulatory region DNA binding (GO:2000678)2.94854531
78negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.94798866
79negative regulation of mast cell activation (GO:0033004)2.94409015
80prenylation (GO:0097354)2.93185598
81protein prenylation (GO:0018342)2.93185598
82regulation of neurotransmitter uptake (GO:0051580)2.92895840
83platelet dense granule organization (GO:0060155)2.90706575
84cholesterol biosynthetic process (GO:0006695)2.89579724
85cell differentiation involved in metanephros development (GO:0072202)2.89577963
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89573942
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89573942
88amine catabolic process (GO:0009310)2.89170126
89cellular biogenic amine catabolic process (GO:0042402)2.89170126
90regulation of hippo signaling (GO:0035330)2.88723078
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88573552
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88573552
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88573552
94dopamine transport (GO:0015872)2.88299181
95detection of light stimulus involved in visual perception (GO:0050908)2.87788286
96detection of light stimulus involved in sensory perception (GO:0050962)2.87788286
97cellular ketone body metabolic process (GO:0046950)2.87023322
98L-methionine salvage (GO:0071267)2.86852615
99L-methionine biosynthetic process (GO:0071265)2.86852615
100amino acid salvage (GO:0043102)2.86852615
101GDP-mannose metabolic process (GO:0019673)2.86135255
102ER overload response (GO:0006983)2.83893428
103regulation of action potential (GO:0098900)2.83520412
104pyrimidine-containing compound transmembrane transport (GO:0072531)2.83174657
105protein polyglutamylation (GO:0018095)2.82148522
106reflex (GO:0060004)2.81682044
107cotranslational protein targeting to membrane (GO:0006613)2.81499717
108deoxyribonucleotide biosynthetic process (GO:0009263)2.79265960
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79008953
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78908671
111neuronal action potential (GO:0019228)2.78097381
112adaptation of signaling pathway (GO:0023058)2.77990018
113fatty acid elongation (GO:0030497)2.77964762
114heart process (GO:0003015)2.77803948
115heart contraction (GO:0060047)2.77803948
116protein targeting to mitochondrion (GO:0006626)2.77469653
117fibril organization (GO:0097435)2.77191471
118multicellular organism reproduction (GO:0032504)2.76027702
119protein maturation by protein folding (GO:0022417)2.75794046
120purine nucleotide transport (GO:0015865)2.74700623
121oxidative phosphorylation (GO:0006119)2.74600244
122behavioral response to ethanol (GO:0048149)2.74307742
123ketone body metabolic process (GO:1902224)2.74300615
124protein targeting to ER (GO:0045047)2.73216928
125protein localization to endoplasmic reticulum (GO:0070972)2.71656599
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.70240690
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70240690
128signal transduction involved in cell cycle checkpoint (GO:0072395)2.68449230
129antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68267073
130sterol biosynthetic process (GO:0016126)2.68160266
131kidney morphogenesis (GO:0060993)2.65849218
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65309323
133regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.65010789
134regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.65010789
135piRNA metabolic process (GO:0034587)2.63556075
136negative regulation of appetite (GO:0032099)2.63146500
137negative regulation of response to food (GO:0032096)2.63146500
138positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.63045609
139regulation of mitochondrial translation (GO:0070129)2.63030129
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62634187
141UTP biosynthetic process (GO:0006228)2.62606819
142regulation of cellular amine metabolic process (GO:0033238)2.62508135
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61731305
144flavonoid metabolic process (GO:0009812)2.61489479
145regulation of glomerulus development (GO:0090192)2.61414475
146GPI anchor metabolic process (GO:0006505)2.61356180
147establishment of protein localization to mitochondrion (GO:0072655)2.60956155
148translation (GO:0006412)2.60422357
149deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60122675
150aromatic amino acid family catabolic process (GO:0009074)2.59871904
151axon ensheathment in central nervous system (GO:0032291)2.59538326
152central nervous system myelination (GO:0022010)2.59538326
153cyclooxygenase pathway (GO:0019371)2.59349464
154deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.59331649
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59266933
156negative regulation of telomere maintenance (GO:0032205)2.59061200
157regulation of cell proliferation involved in kidney development (GO:1901722)2.58964896
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.58814637
159photoreceptor cell development (GO:0042461)2.57529840
160axoneme assembly (GO:0035082)2.56991084
161positive regulation of mitochondrial fission (GO:0090141)2.54947330
162adenine nucleotide transport (GO:0051503)2.54573922
163transmission of nerve impulse (GO:0019226)2.54551658
164somite development (GO:0061053)2.54172553
165spinal cord motor neuron differentiation (GO:0021522)2.53895441
166positive regulation of fatty acid oxidation (GO:0046321)2.52591741
167establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52095853
168regulation of hexokinase activity (GO:1903299)2.51205772
169regulation of glucokinase activity (GO:0033131)2.51205772
170cornea development in camera-type eye (GO:0061303)2.50516281
171positive regulation of fatty acid transport (GO:2000193)2.50485422
172replication fork processing (GO:0031297)2.49375244
173membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48959411
174peristalsis (GO:0030432)2.48085461
175hindbrain development (GO:0030902)2.47331304
176oxidative demethylation (GO:0070989)2.46517265
177otic vesicle formation (GO:0030916)2.45461626
178positive regulation of cAMP-mediated signaling (GO:0043950)2.45048585
179aromatic amino acid family metabolic process (GO:0009072)2.41830112
180mitochondrion morphogenesis (GO:0070584)2.40834631
181male meiosis I (GO:0007141)2.39797946
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.39748118
183synapsis (GO:0007129)2.39079737
184rhodopsin mediated signaling pathway (GO:0016056)2.36070960
185replicative senescence (GO:0090399)2.34679223
186regulation of mesoderm development (GO:2000380)2.34678159
187ubiquinone biosynthetic process (GO:0006744)2.33909757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05678381
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.74626705
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.57782283
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.91366787
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.85546409
6ZNF274_21170338_ChIP-Seq_K562_Hela3.47438262
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.39679242
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28052737
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.18214147
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10716165
11VDR_22108803_ChIP-Seq_LS180_Human2.99149348
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74865935
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70842088
14EZH2_22144423_ChIP-Seq_EOC_Human2.70359077
15* SRF_21415370_ChIP-Seq_HL-1_Mouse2.63909344
16* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58826101
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55999734
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.47612444
19* ELK1_19687146_ChIP-ChIP_HELA_Human2.44435128
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.42497896
21IGF1R_20145208_ChIP-Seq_DFB_Human2.35518248
22GATA1_22025678_ChIP-Seq_K562_Human2.34196010
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33402766
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22989753
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18122647
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05714962
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99333913
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99226957
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99021339
30DCP1A_22483619_ChIP-Seq_HELA_Human1.90294683
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86197672
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85888216
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81959140
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80837510
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.80649165
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79797274
37VDR_23849224_ChIP-Seq_CD4+_Human1.78248092
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77483060
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76097992
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.75490576
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72455624
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69852597
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65244429
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64479496
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63972447
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59585298
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59124024
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58521073
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58521073
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57587243
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.56980172
52* BCAT_22108803_ChIP-Seq_LS180_Human1.56835718
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55517985
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.53700079
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51240289
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50168171
57SMAD4_21799915_ChIP-Seq_A2780_Human1.46022372
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.45466251
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43013641
60AR_25329375_ChIP-Seq_VCAP_Human1.42543227
61* STAT3_23295773_ChIP-Seq_U87_Human1.41558813
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40526655
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39622745
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38483182
65TP53_22573176_ChIP-Seq_HFKS_Human1.37678524
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37169914
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36781641
68CBP_20019798_ChIP-Seq_JUKART_Human1.35219599
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35219599
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33968467
71* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32686539
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.30561877
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30561877
74TCF4_23295773_ChIP-Seq_U87_Human1.30196477
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29227330
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27955197
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.27779803
78TTF2_22483619_ChIP-Seq_HELA_Human1.26720850
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25671990
80SOX2_19829295_ChIP-Seq_ESCs_Human1.25411076
81NANOG_19829295_ChIP-Seq_ESCs_Human1.25411076
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.25062132
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24476616
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24459878
85EWS_26573619_Chip-Seq_HEK293_Human1.24383658
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24061030
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23624518
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23111219
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22429373
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22295152
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.21785533
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.21534067
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21395067
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20714421
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.20469829
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.19813413
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.19061463
98SOX2_20726797_ChIP-Seq_SW620_Human1.18486529
99RNF2_27304074_Chip-Seq_NSC_Mouse1.17714584
100* TCF4_22108803_ChIP-Seq_LS180_Human1.17658328
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.16756323
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16517392
103GABP_19822575_ChIP-Seq_HepG2_Human1.16353583
104* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16201514
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16118156
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15990367
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15833332
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.15285171
109NCOR_22424771_ChIP-Seq_293T_Human1.15022270
110FUS_26573619_Chip-Seq_HEK293_Human1.14028651
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13907827
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13243324
113RUNX2_22187159_ChIP-Seq_PCA_Human1.11900445
114* REST_21632747_ChIP-Seq_MESCs_Mouse1.11283327
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.11040160
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10918661
117AR_20517297_ChIP-Seq_VCAP_Human1.10495497
118* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09229302
119SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07843209
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07424807
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07411669
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.06831057
123XRN2_22483619_ChIP-Seq_HELA_Human1.06736903
124TAF15_26573619_Chip-Seq_HEK293_Human1.06521626
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06489337
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06085608
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06085608
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.05965361
129TP53_16413492_ChIP-PET_HCT116_Human1.05953287
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05012436
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04403390
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.03779314
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03253200
134EZH2_27304074_Chip-Seq_ESCs_Mouse1.02922402
135* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02159715
136P53_22387025_ChIP-Seq_ESCs_Mouse1.01460380
137* FOXP3_21729870_ChIP-Seq_TREG_Human1.00991108
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00279093
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00097759
140JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99487855
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99406856
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98922122
143* STAT3_18555785_Chip-Seq_ESCs_Mouse0.97793737
144ER_23166858_ChIP-Seq_MCF-7_Human0.97604227
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.97355757
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97212290
147JUN_21703547_ChIP-Seq_K562_Human0.96038609
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95432917
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95093372
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94417201
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94037928
152IRF1_19129219_ChIP-ChIP_H3396_Human0.93269716
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91631292
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89718590
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89516027
156EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88952750
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88760109
158* CJUN_26792858_Chip-Seq_BT549_Human0.88392991
159MYC_18940864_ChIP-ChIP_HL60_Human0.87030600
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85970846
161P300_19829295_ChIP-Seq_ESCs_Human0.85555756
162KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85226755
163AR_21909140_ChIP-Seq_LNCAP_Human0.83828643
164GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83025720
165TP53_18474530_ChIP-ChIP_U2OS_Human0.82869082
166MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82742073
167* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80613077
168MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80505262
169GBX2_23144817_ChIP-Seq_PC3_Human0.79864941
170GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79388366
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.78625927
172NANOG_16153702_ChIP-ChIP_HESCs_Human0.77193277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.98353031
2MP0005503_abnormal_tendon_morphology3.60530001
3MP0003186_abnormal_redox_activity3.30726072
4MP0000372_irregular_coat_pigmentation3.25377239
5MP0009697_abnormal_copulation3.13283914
6MP0001542_abnormal_bone_strength3.04848481
7MP0002102_abnormal_ear_morphology2.79288120
8MP0009379_abnormal_foot_pigmentation2.71207804
9MP0003950_abnormal_plasma_membrane2.61634926
10MP0005171_absent_coat_pigmentation2.53775412
11MP0000566_synostosis2.44786463
12MP0006292_abnormal_olfactory_placode2.43758716
13MP0003806_abnormal_nucleotide_metabolis2.37852649
14MP0002837_dystrophic_cardiac_calcinosis2.37557479
15MP0009250_abnormal_appendicular_skeleto2.34731600
16MP0005551_abnormal_eye_electrophysiolog2.31480889
17MP0002282_abnormal_trachea_morphology2.29870702
18MP0005646_abnormal_pituitary_gland2.29161073
19MP0008872_abnormal_physiological_respon2.29070104
20MP0002938_white_spotting2.28468284
21MP0004134_abnormal_chest_morphology2.23258746
22MP0000569_abnormal_digit_pigmentation2.20377336
23MP0001968_abnormal_touch/_nociception2.17771492
24MP0003646_muscle_fatigue2.07349095
25MP0001485_abnormal_pinna_reflex2.05351429
26MP0000762_abnormal_tongue_morphology2.04638091
27MP0008877_abnormal_DNA_methylation2.03021707
28MP0003136_yellow_coat_color1.94799707
29MP0002295_abnormal_pulmonary_circulatio1.94487135
30MP0000749_muscle_degeneration1.92417066
31MP0004147_increased_porphyrin_level1.90007733
32MP0009046_muscle_twitch1.89256491
33MP0003279_aneurysm1.87102518
34MP0001879_abnormal_lymphatic_vessel1.86032521
35MP0008789_abnormal_olfactory_epithelium1.84594415
36MP0004272_abnormal_basement_membrane1.82153430
37MP0005408_hypopigmentation1.81936045
38MP0001905_abnormal_dopamine_level1.81143876
39MP0004885_abnormal_endolymph1.80855364
40MP0002132_abnormal_respiratory_system1.78675798
41MP0006072_abnormal_retinal_apoptosis1.77732780
42MP0004142_abnormal_muscle_tone1.77561115
43MP0004145_abnormal_muscle_electrophysio1.76428639
44MP0009745_abnormal_behavioral_response1.71518731
45MP0002638_abnormal_pupillary_reflex1.70811060
46MP0005174_abnormal_tail_pigmentation1.67514297
47MP0000049_abnormal_middle_ear1.66679928
48MP0005508_abnormal_skeleton_morphology1.66652335
49MP0002272_abnormal_nervous_system1.65213984
50MP0005084_abnormal_gallbladder_morpholo1.63359269
51MP0005275_abnormal_skin_tensile1.63260431
52MP0002138_abnormal_hepatobiliary_system1.62042737
53MP0005253_abnormal_eye_physiology1.62035167
54MP0002736_abnormal_nociception_after1.61311986
55MP0005389_reproductive_system_phenotype1.60692090
56MP0002876_abnormal_thyroid_physiology1.59816621
57MP0000631_abnormal_neuroendocrine_gland1.59301377
58MP0004133_heterotaxia1.54541384
59MP0002933_joint_inflammation1.53472413
60MP0000163_abnormal_cartilage_morphology1.53028366
61MP0009384_cardiac_valve_regurgitation1.49106720
62MP0005360_urolithiasis1.48970195
63MP0003011_delayed_dark_adaptation1.46550101
64MP0005379_endocrine/exocrine_gland_phen1.46439836
65MP0001529_abnormal_vocalization1.45849986
66MP0010030_abnormal_orbit_morphology1.44527649
67MP0003880_abnormal_central_pattern1.43414206
68MP0003718_maternal_effect1.40900598
69MP0006054_spinal_hemorrhage1.39014488
70MP0004782_abnormal_surfactant_physiolog1.35208016
71MP0002928_abnormal_bile_duct1.33074663
72MP0001299_abnormal_eye_distance/1.32568907
73MP0005645_abnormal_hypothalamus_physiol1.32203620
74MP0008932_abnormal_embryonic_tissue1.31893666
75MP0005595_abnormal_vascular_smooth1.28709430
76MP0000427_abnormal_hair_cycle1.28631775
77MP0003724_increased_susceptibility_to1.24837281
78MP0003787_abnormal_imprinting1.23805159
79MP0004043_abnormal_pH_regulation1.23732260
80MP0001177_atelectasis1.22872333
81MP0001984_abnormal_olfaction1.21725084
82MP0002653_abnormal_ependyma_morphology1.20982672
83MP0003656_abnormal_erythrocyte_physiolo1.20019854
84MP0005164_abnormal_response_to1.17489417
85MP0002160_abnormal_reproductive_system1.15830201
86MP0002735_abnormal_chemical_nociception1.12633242
87MP0004883_abnormal_blood_vessel1.12239145
88MP0001243_abnormal_dermal_layer1.12179810
89MP0002095_abnormal_skin_pigmentation1.12097598
90MP0001764_abnormal_homeostasis1.11937362
91MP0002064_seizures1.11887364
92MP0002877_abnormal_melanocyte_morpholog1.11364361
93MP0005409_darkened_coat_color1.11318311
94MP0005410_abnormal_fertilization1.10093130
95MP0002572_abnormal_emotion/affect_behav1.08772948
96MP0005195_abnormal_posterior_eye1.07234822
97MP0003195_calcinosis1.07221830
98MP0003252_abnormal_bile_duct1.06924634
99MP0001970_abnormal_pain_threshold1.06759658
100MP0003755_abnormal_palate_morphology1.05507003
101MP0001486_abnormal_startle_reflex1.04665105
102MP0010368_abnormal_lymphatic_system1.04329684
103MP0005390_skeleton_phenotype1.02696947
104MP0001346_abnormal_lacrimal_gland1.02124821
105MP0002009_preneoplasia1.01836125
106MP0002557_abnormal_social/conspecific_i1.01155275
107MP0000681_abnormal_thyroid_gland1.01131565
108MP0002733_abnormal_thermal_nociception1.01086667
109MP0001501_abnormal_sleep_pattern1.00966708
110MP0005499_abnormal_olfactory_system0.99773537
111MP0005394_taste/olfaction_phenotype0.99773537
112MP0005388_respiratory_system_phenotype0.99216080
113MP0002133_abnormal_respiratory_system0.99216080
114MP0005075_abnormal_melanosome_morpholog0.98588430
115MP0002115_abnormal_skeleton_extremities0.97607096
116MP0008260_abnormal_autophagy0.96849840
117MP0002108_abnormal_muscle_morphology0.95694284
118MP0003942_abnormal_urinary_system0.95580444
119MP0004215_abnormal_myocardial_fiber0.94870679
120MP0002734_abnormal_mechanical_nocicepti0.94597304
121MP0003283_abnormal_digestive_organ0.94164413
122MP0004742_abnormal_vestibular_system0.91729100
123MP0001324_abnormal_eye_pigmentation0.89736087
124MP0001963_abnormal_hearing_physiology0.89446741
125MP0000383_abnormal_hair_follicle0.89384612
126MP0002067_abnormal_sensory_capabilities0.89288409
127MP0000538_abnormal_urinary_bladder0.89145969
128MP0008875_abnormal_xenobiotic_pharmacok0.89123085
129MP0003937_abnormal_limbs/digits/tail_de0.89052573
130MP0001188_hyperpigmentation0.87821827
131MP0004924_abnormal_behavior0.87051973
132MP0005386_behavior/neurological_phenoty0.87051973
133MP0000920_abnormal_myelination0.86826361
134MP0001919_abnormal_reproductive_system0.86429253
135MP0001440_abnormal_grooming_behavior0.86148673
136MP0002752_abnormal_somatic_nervous0.85328271
137MP0001958_emphysema0.84728144
138MP0002233_abnormal_nose_morphology0.83770771
139MP0000015_abnormal_ear_pigmentation0.83099255
140MP0006276_abnormal_autonomic_nervous0.81789953
141MP0003122_maternal_imprinting0.80904470
142MP0004130_abnormal_muscle_cell0.80228183
143MP0008775_abnormal_heart_ventricle0.80216343
144MP0001986_abnormal_taste_sensitivity0.79632972
145MP0003119_abnormal_digestive_system0.79606042
146MP0002163_abnormal_gland_morphology0.79306611
147MP0006036_abnormal_mitochondrial_physio0.79228270
148MP0000516_abnormal_urinary_system0.78589015
149MP0005367_renal/urinary_system_phenotyp0.78589015
150MP0002113_abnormal_skeleton_development0.78243326
151MP0003786_premature_aging0.75975744
152MP0000343_altered_response_to0.74837854
153MP0002249_abnormal_larynx_morphology0.73615023
154MP0005085_abnormal_gallbladder_physiolo0.72691875
155MP0002751_abnormal_autonomic_nervous0.72189345
156MP0010386_abnormal_urinary_bladder0.70904262
157MP0004484_altered_response_of0.70519003
158MP0002109_abnormal_limb_morphology0.70499414
159MP0005332_abnormal_amino_acid0.68955354
160MP0000230_abnormal_systemic_arterial0.68137587
161MP0002177_abnormal_outer_ear0.67307591
162MP0005257_abnormal_intraocular_pressure0.66652763
163MP0000026_abnormal_inner_ear0.66298627
164MP0002127_abnormal_cardiovascular_syste0.66091574
165MP0003385_abnormal_body_wall0.65843761
166MP0002972_abnormal_cardiac_muscle0.65440546
167MP0002896_abnormal_bone_mineralization0.64759334
168MP0002277_abnormal_respiratory_mucosa0.63629784

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.41792494
2Acute necrotizing encephalopathy (HP:0006965)4.26132012
3True hermaphroditism (HP:0010459)3.94521152
4Irregular epiphyses (HP:0010582)3.92702248
5Mitochondrial inheritance (HP:0001427)3.86873674
6Congenital stationary night blindness (HP:0007642)3.76246857
7Abnormal mitochondria in muscle tissue (HP:0008316)3.68943516
8Increased serum pyruvate (HP:0003542)3.67099179
9Abnormality of glycolysis (HP:0004366)3.67099179
10Hepatocellular necrosis (HP:0001404)3.66875597
11Metaphyseal dysplasia (HP:0100255)3.65004839
12Abnormality of midbrain morphology (HP:0002418)3.62842697
13Molar tooth sign on MRI (HP:0002419)3.62842697
14Hepatic necrosis (HP:0002605)3.52446331
15Acute encephalopathy (HP:0006846)3.47868240
16Progressive macrocephaly (HP:0004481)3.42883086
17Increased CSF lactate (HP:0002490)3.35170220
18Abnormal tarsal ossification (HP:0008369)3.31586878
19Hypothermia (HP:0002045)3.29900887
20Nephronophthisis (HP:0000090)3.26359206
21Pendular nystagmus (HP:0012043)3.23814785
22Flat capital femoral epiphysis (HP:0003370)3.23456600
23Abnormality of the phalanges of the 2nd finger (HP:0009541)3.09802067
24Abnormality of the renal cortex (HP:0011035)3.06763792
25Abolished electroretinogram (ERG) (HP:0000550)2.88142863
26Renal Fanconi syndrome (HP:0001994)2.83241154
27Genetic anticipation (HP:0003743)2.79748904
28Abnormality of the renal medulla (HP:0100957)2.79421511
29Epiphyseal dysplasia (HP:0002656)2.75744935
30Submucous cleft hard palate (HP:0000176)2.75637297
31Cystic liver disease (HP:0006706)2.70198921
32Type II lissencephaly (HP:0007260)2.67910438
33Abnormality of alanine metabolism (HP:0010916)2.67653136
34Hyperalaninemia (HP:0003348)2.67653136
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67653136
36Cupped ribs (HP:0000887)2.65728500
37Patent foramen ovale (HP:0001655)2.65324409
38Abnormal rod and cone electroretinograms (HP:0008323)2.64729970
39Adrenal hypoplasia (HP:0000835)2.63680309
40Increased hepatocellular lipid droplets (HP:0006565)2.63607699
41Methylmalonic acidemia (HP:0002912)2.63028125
42Progressive cerebellar ataxia (HP:0002073)2.62357486
43Respiratory failure (HP:0002878)2.61673906
44Keratoconus (HP:0000563)2.57838935
45Increased corneal curvature (HP:0100692)2.57838935
46Attenuation of retinal blood vessels (HP:0007843)2.55274125
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54626163
48Autoamputation (HP:0001218)2.54003667
49Furrowed tongue (HP:0000221)2.53441853
50Premature rupture of membranes (HP:0001788)2.52867658
51Vertebral compression fractures (HP:0002953)2.52252237
52Abnormality of incisor morphology (HP:0011063)2.51658700
53Gaze-evoked nystagmus (HP:0000640)2.51044361
54Renal cortical cysts (HP:0000803)2.49379524
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47791420
56Lipid accumulation in hepatocytes (HP:0006561)2.45893152
57Congenital sensorineural hearing impairment (HP:0008527)2.44548247
58Vitreoretinal degeneration (HP:0000655)2.41160137
59Hyperventilation (HP:0002883)2.39037637
60Respiratory distress (HP:0002098)2.38339011
61Chronic hepatic failure (HP:0100626)2.38115989
62Medial flaring of the eyebrow (HP:0010747)2.37833169
63Chorioretinal atrophy (HP:0000533)2.37491220
64Sclerocornea (HP:0000647)2.36677651
65Exercise intolerance (HP:0003546)2.35830660
66Cerebral hypomyelination (HP:0006808)2.34772891
67Abnormal foot bone ossification (HP:0010675)2.33150897
68Type I transferrin isoform profile (HP:0003642)2.32450347
69Severe muscular hypotonia (HP:0006829)2.30867217
70Congenital primary aphakia (HP:0007707)2.30758224
71Irregular vertebral endplates (HP:0003301)2.30492036
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29804605
73Nephrogenic diabetes insipidus (HP:0009806)2.29663615
74Methylmalonic aciduria (HP:0012120)2.29279178
75Parakeratosis (HP:0001036)2.26633240
76Tubular atrophy (HP:0000092)2.26375178
77Increased serum lactate (HP:0002151)2.23486818
78Gait imbalance (HP:0002141)2.23144887
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20125707
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17830526
81Abnormality of the vertebral endplates (HP:0005106)2.17710813
82Cerebral edema (HP:0002181)2.17584836
83Inability to walk (HP:0002540)2.17436768
84Abnormality of the femoral head (HP:0003368)2.16946672
85Anencephaly (HP:0002323)2.15971408
86Large for gestational age (HP:0001520)2.15784174
87Decreased central vision (HP:0007663)2.15525073
883-Methylglutaconic aciduria (HP:0003535)2.14746317
89Male pseudohermaphroditism (HP:0000037)2.14291395
90Abnormality of renal resorption (HP:0011038)2.13907171
91Leukodystrophy (HP:0002415)2.13423407
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.12280738
93Small epiphyses (HP:0010585)2.11843191
94Absent thumb (HP:0009777)2.11424095
95Short femoral neck (HP:0100864)2.11388221
96Stillbirth (HP:0003826)2.10716846
97Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.09152897
98Abnormality of femoral epiphyses (HP:0006499)2.09152897
99Hypoplasia of the fovea (HP:0007750)2.08995308
100Aplasia/Hypoplasia of the fovea (HP:0008060)2.08995308
101Disproportionate short-trunk short stature (HP:0003521)2.08095553
102Optic disc pallor (HP:0000543)2.07480408
103Aplasia/Hypoplasia of the spleen (HP:0010451)2.06744894
104Genital tract atresia (HP:0001827)2.06336725
105Delayed epiphyseal ossification (HP:0002663)2.06310576
106Aplasia of the musculature (HP:0100854)2.04955387
107Abnormality of the renal collecting system (HP:0004742)2.04907365
108Birth length less than 3rd percentile (HP:0003561)2.03925038
109Polydipsia (HP:0001959)2.03310905
110Abnormal drinking behavior (HP:0030082)2.03310905
111Asplenia (HP:0001746)2.01484558
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01442746
113Absent epiphyses (HP:0010577)2.01442746
114Aplasia/Hypoplasia of the tibia (HP:0005772)2.01098378
115Concave nail (HP:0001598)2.00076571
116Small hand (HP:0200055)1.99863828
117Abnormality of the epiphysis of the femoral head (HP:0010574)1.99834734
118Congenital hepatic fibrosis (HP:0002612)1.99686398
119Reduced antithrombin III activity (HP:0001976)1.99569899
120Split foot (HP:0001839)1.99544998
121Aplasia/hypoplasia of the uterus (HP:0008684)1.98693137
122Abnormality of urine glucose concentration (HP:0011016)1.98292390
123Glycosuria (HP:0003076)1.98292390
124Congenital, generalized hypertrichosis (HP:0004540)1.98098196
125Neuroendocrine neoplasm (HP:0100634)1.97949382
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97070906
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.96386656
128Absent/shortened dynein arms (HP:0200106)1.96386656
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93719967
130Short 1st metacarpal (HP:0010034)1.93719967
131Vaginal atresia (HP:0000148)1.93448566
132Nonimmune hydrops fetalis (HP:0001790)1.92982304
133Lactic acidosis (HP:0003128)1.92659414
134Pheochromocytoma (HP:0002666)1.91934287
135Short hallux (HP:0010109)1.91896000
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.90558344
137Abnormality of the pons (HP:0007361)1.89851716
138Hypoplastic left heart (HP:0004383)1.89461405
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89225382
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89225382
141Patchy hypopigmentation of hair (HP:0011365)1.88373517
142Opisthotonus (HP:0002179)1.87913105
143Hemiparesis (HP:0001269)1.87564620
144Respiratory difficulties (HP:0002880)1.87070215
145Decreased circulating renin level (HP:0003351)1.86560770
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.84979059
147Bony spicule pigmentary retinopathy (HP:0007737)1.84610890
148Abnormality of the umbilical cord (HP:0010881)1.83625891
149Xerostomia (HP:0000217)1.82377659
150Short tibia (HP:0005736)1.81975001
151Prolonged neonatal jaundice (HP:0006579)1.81585134
152Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81077643
153Abnormality of dentin (HP:0010299)1.79931529
154Pulmonary artery stenosis (HP:0004415)1.79869945
155Cerebellar dysplasia (HP:0007033)1.79675918
156Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.78517387
157Bifid uvula (HP:0000193)1.77874567
158Congenital ichthyosiform erythroderma (HP:0007431)1.77605690
159Stenosis of the external auditory canal (HP:0000402)1.77429755
160Constricted visual fields (HP:0001133)1.77328633
161Hypoplasia of the uterus (HP:0000013)1.77229807
162Pancreatic fibrosis (HP:0100732)1.76812447
163Postaxial foot polydactyly (HP:0001830)1.75529395
164Hypoplasia of the pons (HP:0012110)1.75191365
165Progressive inability to walk (HP:0002505)1.75107714
166Abnormality of the intrinsic pathway (HP:0010989)1.74443476
167Abnormality of the phalanges of the 5th finger (HP:0004213)1.74234174
168Ectopic kidney (HP:0000086)1.74147455
169Abnormality of carpal bone ossification (HP:0006257)1.74088719
170Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74041591
171Beaking of vertebral bodies (HP:0004568)1.73539331
172Abnormality of the 2nd finger (HP:0004100)1.72523069
173Bell-shaped thorax (HP:0001591)1.71689717
174Broad-based gait (HP:0002136)1.71637243
175Exertional dyspnea (HP:0002875)1.71073061
176Agitation (HP:0000713)1.69120930
177Abnormality of DNA repair (HP:0003254)1.68244181
178Polyuria (HP:0000103)1.68057507
179Tachypnea (HP:0002789)1.67921757
180Optic nerve hypoplasia (HP:0000609)1.67852008
181Abnormality of the 1st metacarpal (HP:0010009)1.67089881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.45829785
2PBK2.79063405
3EIF2AK12.74672537
4BUB12.73044992
5AKT32.71273602
6LIMK12.63244438
7PIM22.35769365
8EIF2AK32.33456853
9MAP4K22.29916016
10ZAK2.26390926
11WNK32.22960206
12CASK2.07345886
13BMPR1B2.05888852
14TAOK31.96738307
15MYLK1.88083789
16MST41.85922508
17STK161.81475998
18NUAK11.79395407
19BCR1.77446775
20NME11.75168715
21WNK41.73000941
22MAPK131.72669097
23INSRR1.71727315
24PLK21.68815189
25MKNK11.58991795
26BMPR21.57635715
27STK38L1.57435397
28VRK11.56701644
29STK391.54815621
30ERBB31.48471775
31BRSK21.48202345
32PLK41.47874101
33PRPF4B1.45836067
34KDR1.40476614
35CDK81.39381324
36ARAF1.39369021
37SIK31.37398469
38OBSCN1.33438043
39LATS21.26158110
40MAPKAPK51.26034627
41TESK11.26003182
42TIE11.23574689
43DAPK21.20194752
44MAP3K41.19913107
45MKNK21.19273244
46DYRK21.18925371
47TXK1.18858138
48PAK31.18104055
49TNIK1.14425040
50MET1.13122439
51BRAF1.12664582
52STK241.10187203
53TESK21.09513602
54NEK91.06016191
55PRKCG1.05335913
56CSNK1G31.04391544
57PLK31.03740162
58MOS1.03213945
59TRPM71.02131382
60TSSK60.98168099
61PRKCE0.93890493
62EIF2AK20.91820611
63OXSR10.89885917
64NEK60.88835233
65NTRK30.86994508
66WEE10.85710028
67RPS6KA50.84296187
68ABL20.84234715
69SRPK10.83380683
70ILK0.83294114
71PIK3CA0.82668032
72MAPKAPK30.81226358
73PHKG10.81130332
74PHKG20.81130332
75MUSK0.79054002
76CSNK1A1L0.77813154
77TRIM280.75776701
78PRKCI0.72897873
79CSNK1G10.71481799
80PNCK0.70991967
81MARK10.70978298
82BCKDK0.70624805
83VRK20.69955750
84TAF10.68259295
85ADRBK20.67892846
86IRAK30.67330306
87CAMK2D0.66935124
88ROCK20.66602920
89EPHB20.66399100
90ADRBK10.65886027
91GRK50.65875985
92GRK70.64456931
93FLT30.62992373
94FRK0.62976102
95TLK10.62030696
96MAP2K60.61959894
97ACVR1B0.60467257
98IKBKB0.60257584
99PRKD20.59015845
100PAK20.58127828
101BRSK10.57943726
102ROCK10.56668415
103CAMK2B0.56663330
104KIT0.55593043
105PDK20.54256221
106MAPK150.53912071
107PTK2B0.53464808
108MAP3K30.53362612
109CSNK2A10.52718978
110CSNK1A10.52345052
111PAK10.52137868
112CAMK2G0.52080439
113FGFR20.50377254
114EPHA30.48814685
115PRKCQ0.48197864
116TEC0.44750364
117YES10.44261944
118PRKACA0.44200113
119CAMKK20.43397574
120IRAK10.43037407
121PKN10.42909892
122CLK10.42667046
123IRAK40.42030515
124DDR20.41814632
125AURKA0.41511208
126STK110.41471987
127GRK10.41414942
128FER0.39842435
129PRKG10.39661106
130MAP2K10.37905435
131PINK10.37877463
132ERBB20.37370403
133PRKG20.37316123
134CDK140.37135425
135CDK190.37107466
136CSNK1G20.37105071
137BLK0.36732118
138PRKAA10.35922057
139MAPKAPK20.35638995
140PRKCA0.35507727
141CDC70.34986078
142MAP2K70.34613809
143PLK10.34005987
144PRKAA20.33872381
145SCYL20.32628503
146TGFBR10.32227598
147STK30.32180060
148CHEK20.32024877
149MAPK40.31742973
150CAMK2A0.31735186
151MAP3K120.31059715

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.59627690
2Proteasome_Homo sapiens_hsa030504.12646514
3Oxidative phosphorylation_Homo sapiens_hsa001903.93913697
4Parkinsons disease_Homo sapiens_hsa050123.20416557
5RNA polymerase_Homo sapiens_hsa030203.04861980
6Ribosome_Homo sapiens_hsa030102.92681158
7Sulfur metabolism_Homo sapiens_hsa009202.40162208
8Phototransduction_Homo sapiens_hsa047442.38761864
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.36779846
10Huntingtons disease_Homo sapiens_hsa050162.36237542
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.34777392
12Nitrogen metabolism_Homo sapiens_hsa009102.32792062
13Alzheimers disease_Homo sapiens_hsa050102.24933786
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13579330
15Steroid biosynthesis_Homo sapiens_hsa001002.09327441
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08540261
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07843756
18Tryptophan metabolism_Homo sapiens_hsa003802.03626710
19Fatty acid elongation_Homo sapiens_hsa000622.00277724
20Caffeine metabolism_Homo sapiens_hsa002321.98544973
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89400597
22Nicotine addiction_Homo sapiens_hsa050331.68714394
23Pyrimidine metabolism_Homo sapiens_hsa002401.66708256
24Glutathione metabolism_Homo sapiens_hsa004801.62542227
25Arachidonic acid metabolism_Homo sapiens_hsa005901.53277917
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52336443
27Folate biosynthesis_Homo sapiens_hsa007901.44043222
28Fanconi anemia pathway_Homo sapiens_hsa034601.41659193
29Basal transcription factors_Homo sapiens_hsa030221.41463398
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40367584
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39967080
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39531209
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36817418
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36383174
35Nucleotide excision repair_Homo sapiens_hsa034201.33859215
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29559823
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29060107
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28342978
39Vibrio cholerae infection_Homo sapiens_hsa051101.27584550
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26341907
41Morphine addiction_Homo sapiens_hsa050321.24456458
42DNA replication_Homo sapiens_hsa030301.23371604
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21150279
44Taste transduction_Homo sapiens_hsa047421.21126480
45Purine metabolism_Homo sapiens_hsa002301.16865315
46Non-homologous end-joining_Homo sapiens_hsa034501.15657731
47Chemical carcinogenesis_Homo sapiens_hsa052041.15193623
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15166825
49Pyruvate metabolism_Homo sapiens_hsa006201.12066861
50Homologous recombination_Homo sapiens_hsa034401.10778682
51Olfactory transduction_Homo sapiens_hsa047401.09142007
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03677493
53Base excision repair_Homo sapiens_hsa034101.01381489
54Mismatch repair_Homo sapiens_hsa034301.00459933
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00268938
56Peroxisome_Homo sapiens_hsa041461.00217203
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.96771218
58Insulin secretion_Homo sapiens_hsa049110.95705852
59Sphingolipid metabolism_Homo sapiens_hsa006000.95682886
60ABC transporters_Homo sapiens_hsa020100.95017766
61* Metabolic pathways_Homo sapiens_hsa011000.94056489
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93011125
63Glycerolipid metabolism_Homo sapiens_hsa005610.90831076
64Arginine and proline metabolism_Homo sapiens_hsa003300.89877933
65Rheumatoid arthritis_Homo sapiens_hsa053230.87364229
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.86901660
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86471359
68Phagosome_Homo sapiens_hsa041450.86416834
69Ether lipid metabolism_Homo sapiens_hsa005650.86046934
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84572636
71Fat digestion and absorption_Homo sapiens_hsa049750.84260540
72Collecting duct acid secretion_Homo sapiens_hsa049660.84179723
73Cardiac muscle contraction_Homo sapiens_hsa042600.81251801
74Sulfur relay system_Homo sapiens_hsa041220.80595120
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.80487718
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.80434366
77Circadian entrainment_Homo sapiens_hsa047130.80409873
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78670032
79GABAergic synapse_Homo sapiens_hsa047270.78443797
80Serotonergic synapse_Homo sapiens_hsa047260.77653853
81RNA degradation_Homo sapiens_hsa030180.75763329
82Tyrosine metabolism_Homo sapiens_hsa003500.75349162
83Glutamatergic synapse_Homo sapiens_hsa047240.75346704
84Retinol metabolism_Homo sapiens_hsa008300.74369370
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73532542
86Mineral absorption_Homo sapiens_hsa049780.72714152
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71954733
88RNA transport_Homo sapiens_hsa030130.68365814
89ECM-receptor interaction_Homo sapiens_hsa045120.68037338
90Histidine metabolism_Homo sapiens_hsa003400.67770447
91Malaria_Homo sapiens_hsa051440.66726387
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64955197
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64581945
94Salivary secretion_Homo sapiens_hsa049700.62420430
95Ovarian steroidogenesis_Homo sapiens_hsa049130.61626095
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60380213
97* N-Glycan biosynthesis_Homo sapiens_hsa005100.60178425
98Calcium signaling pathway_Homo sapiens_hsa040200.59716431
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.59706013
100Systemic lupus erythematosus_Homo sapiens_hsa053220.59678162
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59643260
102Selenocompound metabolism_Homo sapiens_hsa004500.58834795
103Linoleic acid metabolism_Homo sapiens_hsa005910.58467871
104Starch and sucrose metabolism_Homo sapiens_hsa005000.58074332
105Galactose metabolism_Homo sapiens_hsa000520.57395144
106Vitamin digestion and absorption_Homo sapiens_hsa049770.56976236
107Dorso-ventral axis formation_Homo sapiens_hsa043200.55652866
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51817401
109Propanoate metabolism_Homo sapiens_hsa006400.50751947
110Spliceosome_Homo sapiens_hsa030400.49453935
111TGF-beta signaling pathway_Homo sapiens_hsa043500.48887959
112Carbon metabolism_Homo sapiens_hsa012000.47700267
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43107077
114Dopaminergic synapse_Homo sapiens_hsa047280.42600415
115Cell cycle_Homo sapiens_hsa041100.42516651
116Hedgehog signaling pathway_Homo sapiens_hsa043400.41012122
117Regulation of autophagy_Homo sapiens_hsa041400.40134294
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39479299
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38386650
120Butanoate metabolism_Homo sapiens_hsa006500.38254287
121Asthma_Homo sapiens_hsa053100.37466064
122Circadian rhythm_Homo sapiens_hsa047100.37262468
123Fatty acid degradation_Homo sapiens_hsa000710.36516369
124Melanoma_Homo sapiens_hsa052180.36401350
125Primary immunodeficiency_Homo sapiens_hsa053400.32833800
126Protein digestion and absorption_Homo sapiens_hsa049740.32799601
127One carbon pool by folate_Homo sapiens_hsa006700.31098883
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.30390011
129Phenylalanine metabolism_Homo sapiens_hsa003600.30244654
130Vitamin B6 metabolism_Homo sapiens_hsa007500.28250028
131beta-Alanine metabolism_Homo sapiens_hsa004100.27950159
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26785920
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25923133
134Biosynthesis of amino acids_Homo sapiens_hsa012300.25910789
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24065036
136Fatty acid metabolism_Homo sapiens_hsa012120.23760635
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22854592

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