ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	4.54141683
2	cullin deneddylation (GO:0010388)	4.13682361
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.07494814
4	epithelial cilium movement (GO:0003351)	4.06423304
5	proteasome assembly (GO:0043248)	4.03710671
6	base-excision repair, AP site formation (GO:0006285)	3.98661358
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.96470316
8	cilium movement (GO:0003341)	3.84074207
9	glyoxylate metabolic process (GO:0046487)	3.83171419
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.81013380
11	ATP synthesis coupled proton transport (GO:0015986)	3.81013380
12	protein deneddylation (GO:0000338)	3.80189672
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.73318395
14	aldehyde catabolic process (GO:0046185)	3.66775554
15	protein complex biogenesis (GO:0070271)	3.63020112
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57745308
17	NADH dehydrogenase complex assembly (GO:0010257)	3.57745308
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57745308
19	positive regulation of mitochondrial fission (GO:0090141)	3.54372248
20	GTP biosynthetic process (GO:0006183)	3.48268015
21	chaperone-mediated protein transport (GO:0072321)	3.48059361
22	motile cilium assembly (GO:0044458)	3.47251686
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.43156565
24	protein-cofactor linkage (GO:0018065)	3.38720718
25	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.37898501
26	electron transport chain (GO:0022900)	3.37777111
27	respiratory electron transport chain (GO:0022904)	3.34654789
28	respiratory chain complex IV assembly (GO:0008535)	3.30772129
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.30477793
30	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.22406189
31	regulation of cellular amino acid metabolic process (GO:0006521)	3.17620827
32	DNA double-strand break processing (GO:0000729)	3.12717767
33	peptidyl-histidine modification (GO:0018202)	3.11984708
34	ubiquinone biosynthetic process (GO:0006744)	3.11285479
35	intraciliary transport (GO:0042073)	3.11074372
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11014447
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11014447
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.10778688
39	regulation of mitochondrial translation (GO:0070129)	3.10643393
40	axoneme assembly (GO:0035082)	3.07956076
41	phenylpropanoid metabolic process (GO:0009698)	3.05277683
42	UTP biosynthetic process (GO:0006228)	3.02735786
43	pseudouridine synthesis (GO:0001522)	3.02524727
44	L-methionine salvage (GO:0071267)	3.01861155
45	L-methionine biosynthetic process (GO:0071265)	3.01861155
46	amino acid salvage (GO:0043102)	3.01861155
47	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.01649276
48	cytochrome complex assembly (GO:0017004)	2.97401878
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.93983162
50	mannosylation (GO:0097502)	2.93460821
51	ubiquinone metabolic process (GO:0006743)	2.93049153
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92529047
53	protein neddylation (GO:0045116)	2.92495394
54	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90326408
55	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.89000087
56	negative regulation of ligase activity (GO:0051352)	2.89000087
57	histone H2A acetylation (GO:0043968)	2.88309463
58	oxidative phosphorylation (GO:0006119)	2.86994005
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.83922205
60	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.83922205
61	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.83922205
62	nucleoside diphosphate phosphorylation (GO:0006165)	2.82744868
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82680650
64	termination of RNA polymerase III transcription (GO:0006386)	2.82680650
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.80119413
66	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.80119413
67	UTP metabolic process (GO:0046051)	2.78580670
68	sequestering of actin monomers (GO:0042989)	2.78193526
69	protein targeting to mitochondrion (GO:0006626)	2.78036812
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.78015028
71	peptidyl-arginine methylation (GO:0018216)	2.77636695
72	peptidyl-arginine N-methylation (GO:0035246)	2.77636695
73	CTP metabolic process (GO:0046036)	2.77623310
74	CTP biosynthetic process (GO:0006241)	2.77623310
75	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.77259197
76	C-terminal protein lipidation (GO:0006501)	2.77087205
77	branched-chain amino acid catabolic process (GO:0009083)	2.77069228
78	metallo-sulfur cluster assembly (GO:0031163)	2.76542471
79	iron-sulfur cluster assembly (GO:0016226)	2.76542471
80	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75864538
81	C-terminal protein amino acid modification (GO:0018410)	2.74700087
82	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.74090578
83	protein localization to mitochondrion (GO:0070585)	2.73603278
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73029606
85	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73029606
86	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67089872
87	water-soluble vitamin biosynthetic process (GO:0042364)	2.66752480
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.66726524
89	pyrimidine nucleotide catabolic process (GO:0006244)	2.66033775
90	serine family amino acid catabolic process (GO:0009071)	2.64132924
91	establishment of protein localization to mitochondrion (GO:0072655)	2.63573413
92	DNA damage response, detection of DNA damage (GO:0042769)	2.63456608
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.60897894
94	intracellular protein transmembrane import (GO:0044743)	2.60896890
95	rRNA modification (GO:0000154)	2.60485044
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60257806
97	left/right pattern formation (GO:0060972)	2.59818954
98	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.59648553
99	quinone biosynthetic process (GO:1901663)	2.55893928
100	ATP biosynthetic process (GO:0006754)	2.55829874

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.57076584
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.46388910
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.22267839
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.89629939
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.60480493
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.56308385
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17620962
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92919438
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.71287146
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.58569264
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.34161459
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32258970
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.26688439
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21405060
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.19540076
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.18953452
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.17615339
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17417363
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16550412
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.01648693
21	VDR_22108803_ChIP-Seq_LS180_Human	1.99360264
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97996183
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.96237089
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.96064636
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.94738280
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.93915386
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89226620
28	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.84454434
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83706474
30	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.75786354
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73157013
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70661191
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.70006250
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69479419
35	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.67894360
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.63027674
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.61771686
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.59680463
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.56484090
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.49301560
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.48757903
42	HTT_18923047_ChIP-ChIP_STHdh_Human	1.48473168
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.45186849
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44944110
45	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.43773748
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43368121
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.42492600
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41832424
49	EWS_26573619_Chip-Seq_HEK293_Human	1.39005064
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.37486252
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34219618
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.32166462
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.31345632
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27801546
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22527518
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.21830775
57	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.21497916
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21216635
59	AR_20517297_ChIP-Seq_VCAP_Human	1.15988560
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.14641108
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13396200
62	FUS_26573619_Chip-Seq_HEK293_Human	1.12149169
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.11325677
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09559921
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.08927214
66	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.08674032
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06735900
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.05620839
69	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04662446
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.03565250
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03528407
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.02276949
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02056131
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.01987162
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01057745
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00635858
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98996170
78	NCOR_22424771_ChIP-Seq_293T_Human	0.98570758
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98099246
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98099246
81	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.97153653
82	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.91492984
83	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.91309580
84	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.89448678
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89337695
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88200905
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87994368
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87452650
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86974096
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.85472421
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84743186
92	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.83662301
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.82839498
94	* ERA_21632823_ChIP-Seq_H3396_Human	0.82170073
95	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.81252125
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.81194694
97	TAF15_26573619_Chip-Seq_HEK293_Human	0.80849853
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.80553921
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.80361824
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80131411

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.10686291
2	MP0008875_abnormal_xenobiotic_pharmacok	2.83774574
3	MP0008058_abnormal_DNA_repair	2.77642672
4	MP0003806_abnormal_nucleotide_metabolis	2.71665341
5	MP0009697_abnormal_copulation	2.66199262
6	MP0005085_abnormal_gallbladder_physiolo	2.39303935
7	MP0003195_calcinosis	2.26038958
8	MP0008789_abnormal_olfactory_epithelium	2.12641847
9	MP0000372_irregular_coat_pigmentation	2.09027969
10	MP0006072_abnormal_retinal_apoptosis	1.97430604
11	MP0002653_abnormal_ependyma_morphology	1.97151045
12	MP0005365_abnormal_bile_salt	1.93085063
13	MP0004133_heterotaxia	1.92518637
14	MP0001529_abnormal_vocalization	1.88445142
15	MP0001764_abnormal_homeostasis	1.87328663
16	MP0006036_abnormal_mitochondrial_physio	1.85880387
17	MP0008995_early_reproductive_senescence	1.75499383
18	MP0006035_abnormal_mitochondrial_morpho	1.71804659
19	MP0005394_taste/olfaction_phenotype	1.69375448
20	MP0005499_abnormal_olfactory_system	1.69375448
21	MP0003693_abnormal_embryo_hatching	1.68568990
22	MP0008877_abnormal_DNA_methylation	1.65830934
23	MP0002837_dystrophic_cardiac_calcinosis	1.60872179
24	MP0003186_abnormal_redox_activity	1.59728520
25	MP0005360_urolithiasis	1.56365373
26	MP0002876_abnormal_thyroid_physiology	1.54039350
27	MP0005253_abnormal_eye_physiology	1.53332036
28	MP0010030_abnormal_orbit_morphology	1.52228441
29	MP0000566_synostosis	1.50902935
30	MP0002234_abnormal_pharynx_morphology	1.49981081
31	MP0000049_abnormal_middle_ear	1.49567996
32	MP0002139_abnormal_hepatobiliary_system	1.48778214
33	MP0003718_maternal_effect	1.44823290
34	MP0003786_premature_aging	1.44165737
35	MP0010094_abnormal_chromosome_stability	1.44119366
36	MP0005083_abnormal_biliary_tract	1.42663236
37	MP0008932_abnormal_embryonic_tissue	1.36507155
38	MP0005551_abnormal_eye_electrophysiolog	1.36016579
39	MP0004147_increased_porphyrin_level	1.35857928
40	MP0003011_delayed_dark_adaptation	1.34480432
41	MP0001984_abnormal_olfaction	1.33474791
42	MP0002736_abnormal_nociception_after	1.33323365
43	MP0009046_muscle_twitch	1.33322334
44	MP0005187_abnormal_penis_morphology	1.31753271
45	MP0000383_abnormal_hair_follicle	1.31287853
46	MP0005646_abnormal_pituitary_gland	1.28837220
47	MP0008872_abnormal_physiological_respon	1.27488028
48	MP0002160_abnormal_reproductive_system	1.23047789
49	MP0002751_abnormal_autonomic_nervous	1.21128491
50	MP0004957_abnormal_blastocyst_morpholog	1.20503723
51	MP0010386_abnormal_urinary_bladder	1.20085680
52	MP0004270_analgesia	1.15000855
53	MP0002249_abnormal_larynx_morphology	1.14693427
54	MP0002822_catalepsy	1.13645413
55	MP0002282_abnormal_trachea_morphology	1.12761953
56	MP0003880_abnormal_central_pattern	1.12517957
57	MP0001346_abnormal_lacrimal_gland	1.10225940
58	MP0002090_abnormal_vision	1.10218867
59	MP0005332_abnormal_amino_acid	1.08935807
60	MP0000631_abnormal_neuroendocrine_gland	1.08890243
61	MP0006292_abnormal_olfactory_placode	1.04763154
62	MP0003937_abnormal_limbs/digits/tail_de	1.03288200
63	MP0003136_yellow_coat_color	1.02363729
64	MP0002132_abnormal_respiratory_system	1.01641884
65	MP0004019_abnormal_vitamin_homeostasis	1.01298089
66	MP0006276_abnormal_autonomic_nervous	1.00544911
67	MP0003938_abnormal_ear_development	1.00455566
68	MP0003137_abnormal_impulse_conducting	0.99621386
69	MP0000647_abnormal_sebaceous_gland	0.99293780
70	MP0003121_genomic_imprinting	0.97723979
71	MP0002233_abnormal_nose_morphology	0.97033367
72	MP0001293_anophthalmia	0.96478853
73	MP0001929_abnormal_gametogenesis	0.96103403
74	MP0003221_abnormal_cardiomyocyte_apopto	0.91388744
75	MP0003122_maternal_imprinting	0.90856863
76	MP0002254_reproductive_system_inflammat	0.90577228
77	MP0003315_abnormal_perineum_morphology	0.90268586
78	MP0002138_abnormal_hepatobiliary_system	0.90196119
79	MP0001485_abnormal_pinna_reflex	0.88772228
80	MP0004043_abnormal_pH_regulation	0.87469961
81	MP0001968_abnormal_touch/_nociception	0.86976573
82	MP0003698_abnormal_male_reproductive	0.86852325
83	MP0002098_abnormal_vibrissa_morphology	0.85961240
84	MP0003077_abnormal_cell_cycle	0.85626944
85	MP0002210_abnormal_sex_determination	0.85271651
86	MP0005645_abnormal_hypothalamus_physiol	0.85268121
87	MP0003787_abnormal_imprinting	0.84898370
88	MP0005636_abnormal_mineral_homeostasis	0.84032504
89	MP0003111_abnormal_nucleus_morphology	0.82712700
90	MP0009745_abnormal_behavioral_response	0.81903687
91	MP0000653_abnormal_sex_gland	0.81841292
92	MP0005391_vision/eye_phenotype	0.81189301
93	MP0001905_abnormal_dopamine_level	0.81181609
94	MP0005379_endocrine/exocrine_gland_phen	0.79374661
95	MP0004215_abnormal_myocardial_fiber	0.74146925
96	MP0001145_abnormal_male_reproductive	0.74132288
97	MP0002909_abnormal_adrenal_gland	0.70267955
98	MP0003252_abnormal_bile_duct	0.69873914
99	MP0002277_abnormal_respiratory_mucosa	0.69080370
100	MP0005395_other_phenotype	0.68943528

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.33429117
2	Abnormal respiratory epithelium morphology (HP:0012253)	4.18040904
3	Abnormal respiratory motile cilium morphology (HP:0005938)	4.18040904
4	Abnormal respiratory motile cilium physiology (HP:0012261)	4.10541682
5	Abnormal ciliary motility (HP:0012262)	3.89992173
6	Acute necrotizing encephalopathy (HP:0006965)	3.85608664
7	Rhinitis (HP:0012384)	3.83653570
8	Acute encephalopathy (HP:0006846)	3.62008776
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.55563865
10	Pancreatic cysts (HP:0001737)	3.51505729
11	Mitochondrial inheritance (HP:0001427)	3.42604101
12	Pancreatic fibrosis (HP:0100732)	3.41828767
13	True hermaphroditism (HP:0010459)	3.35696493
14	Increased CSF lactate (HP:0002490)	3.33136347
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.29402770
16	Absent/shortened dynein arms (HP:0200106)	3.29402770
17	Chronic bronchitis (HP:0004469)	3.17154722
18	Hepatocellular necrosis (HP:0001404)	3.16498575
19	Progressive macrocephaly (HP:0004481)	3.00991301
20	Hepatic necrosis (HP:0002605)	2.97994320
21	Cerebral edema (HP:0002181)	2.95277009
22	Abnormality of midbrain morphology (HP:0002418)	2.93830571
23	Molar tooth sign on MRI (HP:0002419)	2.93830571
24	3-Methylglutaconic aciduria (HP:0003535)	2.84976627
25	Medial flaring of the eyebrow (HP:0010747)	2.78855828
26	Delayed CNS myelination (HP:0002188)	2.76771688
27	Nephrogenic diabetes insipidus (HP:0009806)	2.72520744
28	Congenital primary aphakia (HP:0007707)	2.71078457
29	Nephronophthisis (HP:0000090)	2.65984611
30	Gait imbalance (HP:0002141)	2.65949772
31	Occipital encephalocele (HP:0002085)	2.54219803
32	Lactic acidosis (HP:0003128)	2.54033230
33	Type I transferrin isoform profile (HP:0003642)	2.50382791
34	Increased serum lactate (HP:0002151)	2.46532582
35	Bile duct proliferation (HP:0001408)	2.45010615
36	Abnormal biliary tract physiology (HP:0012439)	2.45010615
37	Cystic liver disease (HP:0006706)	2.44634488
38	Renal Fanconi syndrome (HP:0001994)	2.38970461
39	Sclerocornea (HP:0000647)	2.34708517
40	Lipid accumulation in hepatocytes (HP:0006561)	2.34422865
41	Methylmalonic aciduria (HP:0012120)	2.34312943
42	Lethargy (HP:0001254)	2.30598027
43	Anencephaly (HP:0002323)	2.28205646
44	Respiratory failure (HP:0002878)	2.27613698
45	Bronchiectasis (HP:0002110)	2.26139319
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.24283707
47	Abnormal protein N-linked glycosylation (HP:0012347)	2.24283707
48	Abnormal protein glycosylation (HP:0012346)	2.24283707
49	Abnormal glycosylation (HP:0012345)	2.24283707
50	Increased hepatocellular lipid droplets (HP:0006565)	2.22364105
51	Generalized aminoaciduria (HP:0002909)	2.20253158
52	Postaxial foot polydactyly (HP:0001830)	2.19321692
53	Vaginal atresia (HP:0000148)	2.18019894
54	Reduced antithrombin III activity (HP:0001976)	2.16264781
55	Concave nail (HP:0001598)	2.13876813
56	Genital tract atresia (HP:0001827)	2.13733890
57	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13623149
58	Abnormality of glycine metabolism (HP:0010895)	2.13623149
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12246483
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11921265
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11921265
62	Hyperglycinemia (HP:0002154)	2.08986190
63	Prolonged partial thromboplastin time (HP:0003645)	2.07027903
64	Abnormality of the renal medulla (HP:0100957)	2.06460820
65	Limb dystonia (HP:0002451)	2.06371963
66	Optic disc pallor (HP:0000543)	2.04509591
67	Hyperglycinuria (HP:0003108)	2.02732434
68	Abnormality of the labia minora (HP:0012880)	1.99168442
69	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.93962204
70	Intestinal atresia (HP:0011100)	1.93482663
71	Preaxial hand polydactyly (HP:0001177)	1.93084050
72	Exercise intolerance (HP:0003546)	1.89160938
73	Methylmalonic acidemia (HP:0002912)	1.84915533
74	Abnormality of urine glucose concentration (HP:0011016)	1.83963218
75	Glycosuria (HP:0003076)	1.83963218
76	Male pseudohermaphroditism (HP:0000037)	1.81844327
77	Abnormality of serum amino acid levels (HP:0003112)	1.81401521
78	Chronic hepatic failure (HP:0100626)	1.81373959
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80167385
80	Colon cancer (HP:0003003)	1.79889713
81	X-linked dominant inheritance (HP:0001423)	1.78386104
82	Asplenia (HP:0001746)	1.77801717
83	Abnormality of pyrimidine metabolism (HP:0004353)	1.76902827
84	Leukodystrophy (HP:0002415)	1.76678791
85	Congenital hepatic fibrosis (HP:0002612)	1.76110743
86	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.75296885
87	Hyperphosphaturia (HP:0003109)	1.72728371
88	Postaxial hand polydactyly (HP:0001162)	1.71494871
89	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.71165171
90	Dicarboxylic aciduria (HP:0003215)	1.71165171
91	Thyroid-stimulating hormone excess (HP:0002925)	1.69609719
92	Hyperammonemia (HP:0001987)	1.69451088
93	Increased intramyocellular lipid droplets (HP:0012240)	1.68085261
94	Tubulointerstitial nephritis (HP:0001970)	1.67984133
95	Intrahepatic cholestasis (HP:0001406)	1.66781779
96	Poor coordination (HP:0002370)	1.66266787
97	Renal cortical cysts (HP:0000803)	1.65713428
98	Abnormality of the renal cortex (HP:0011035)	1.65290825
99	Ketosis (HP:0001946)	1.64987438
100	Decreased testicular size (HP:0008734)	1.64522472

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.59015434
2	MAP4K2	3.14551934
3	SRPK1	3.08572213
4	NME1	2.82402833
5	PBK	2.81158156
6	TRIM28	2.64479053
7	BCKDK	2.62136490
8	STK16	2.55189322
9	BUB1	2.47616889
10	ZAK	2.43788348
11	MAP3K4	2.22673707
12	CSNK1G3	2.09418381
13	BCR	1.99291281
14	NUAK1	1.97346495
15	ERBB3	1.96186335
16	MUSK	1.92919961
17	CSNK1G1	1.87166526
18	CSNK1G2	1.85561194
19	WNK3	1.83548514
20	CSNK1A1L	1.80469851
21	VRK1	1.74032277
22	MAP2K7	1.67063480
23	GRK1	1.51768257
24	MST4	1.46411598
25	TSSK6	1.42219423
26	EPHA2	1.38244047
27	TESK2	1.36637847
28	EPHA4	1.33889998
29	MST1R	1.32606857
30	PINK1	1.32236944
31	MAP3K12	1.27198593
32	TTK	1.26390761
33	DYRK2	1.24821378
34	MAPK15	1.19641033
35	PLK3	1.16171321
36	LIMK1	1.15910571
37	PLK4	1.12105412
38	BRSK1	1.10993188
39	ADRBK2	1.08930353
40	MAPKAPK3	1.02924713
41	DYRK3	1.02780527
42	DAPK1	1.02395905
43	NME2	1.01689064
44	CASK	1.00984620
45	STK38L	0.98328453
46	PLK1	0.97477146
47	MAPK13	0.96705573
48	KDR	0.94264867
49	CDK8	0.92717916
50	INSRR	0.92002406
51	BRSK2	0.91650102
52	NEK1	0.90840744
53	OXSR1	0.87237216
54	PRKCI	0.86825316
55	TESK1	0.83298248
56	PDK2	0.82387359
57	CDK19	0.81941839
58	AURKA	0.81159993
59	RPS6KA4	0.80017574
60	EIF2AK3	0.77294933
61	ATR	0.75727139
62	TAF1	0.66685794
63	AURKB	0.63563915
64	MINK1	0.60911064
65	EIF2AK1	0.60796039
66	GRK5	0.60665510
67	CHEK2	0.60155045
68	CSNK2A1	0.59362541
69	TLK1	0.58928616
70	FRK	0.58577215
71	CSNK1A1	0.56791047
72	STK39	0.56750440
73	MAP3K5	0.56679076
74	PRKCE	0.55039417
75	PHKG1	0.54366662
76	PHKG2	0.54366662
77	EIF2AK2	0.52086980
78	MAP2K4	0.51725820
79	UHMK1	0.50688568
80	CAMK2A	0.48784238
81	PRKCG	0.48402550
82	CAMK2B	0.47819051
83	RPS6KA5	0.47036371
84	CSNK2A2	0.46649152
85	CDC7	0.46312701
86	OBSCN	0.44943871
87	PASK	0.44566471
88	CCNB1	0.44514449
89	CAMK2G	0.44174915
90	MARK1	0.40045807
91	CDK9	0.39868515
92	CDK7	0.39423899
93	WEE1	0.37710728
94	DYRK1A	0.37420896
95	PRKACB	0.35963637
96	PRKACA	0.35757620
97	CSNK1E	0.34598783
98	ATM	0.34517910
99	PIM2	0.33912961
100	PAK3	0.33172650

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.35662490
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.82390246
3	Parkinsons disease_Homo sapiens_hsa05012	2.43251599
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.16277305
5	RNA polymerase_Homo sapiens_hsa03020	2.12783354
6	Huntingtons disease_Homo sapiens_hsa05016	2.11939089
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10676630
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99590716
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.99079659
10	Base excision repair_Homo sapiens_hsa03410	1.90747467
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.83889374
12	Mismatch repair_Homo sapiens_hsa03430	1.82725942
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.80889009
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.77326566
15	Fatty acid elongation_Homo sapiens_hsa00062	1.72778434
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67237126
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.66976223
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61429641
19	Propanoate metabolism_Homo sapiens_hsa00640	1.59871505
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59438540
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.59260011
22	DNA replication_Homo sapiens_hsa03030	1.56641465
23	Alzheimers disease_Homo sapiens_hsa05010	1.56336871
24	Peroxisome_Homo sapiens_hsa04146	1.52052104
25	Sulfur relay system_Homo sapiens_hsa04122	1.52020302
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.51048874
27	Homologous recombination_Homo sapiens_hsa03440	1.44248727
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.42358067
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42182426
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41445497
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.41214462
32	Retinol metabolism_Homo sapiens_hsa00830	1.40886924
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39631351
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39236162
35	Butanoate metabolism_Homo sapiens_hsa00650	1.38493702
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.36569841
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.36552906
38	Protein export_Homo sapiens_hsa03060	1.35484049
39	Ribosome_Homo sapiens_hsa03010	1.34341555
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.25858219
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.21923966
42	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21879432
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.21316603
44	Spliceosome_Homo sapiens_hsa03040	1.19520540
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19282334
46	Glutathione metabolism_Homo sapiens_hsa00480	1.19100109
47	Arginine biosynthesis_Homo sapiens_hsa00220	1.18012520
48	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16122789
49	Tyrosine metabolism_Homo sapiens_hsa00350	1.15961911
50	Pyruvate metabolism_Homo sapiens_hsa00620	1.15692653
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15378348
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.14704541
53	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14405957
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14309528
55	Basal transcription factors_Homo sapiens_hsa03022	1.14133458
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14113364
57	Carbon metabolism_Homo sapiens_hsa01200	1.11968143
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10701316
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08491613
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04640759
61	RNA transport_Homo sapiens_hsa03013	1.04547500
62	Sulfur metabolism_Homo sapiens_hsa00920	1.03695915
63	Fatty acid degradation_Homo sapiens_hsa00071	1.02912739
64	Caffeine metabolism_Homo sapiens_hsa00232	1.01709297
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.99839449
66	Metabolic pathways_Homo sapiens_hsa01100	0.99251366
67	Phototransduction_Homo sapiens_hsa04744	0.98697226
68	Histidine metabolism_Homo sapiens_hsa00340	0.98548032
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96615659
70	One carbon pool by folate_Homo sapiens_hsa00670	0.94952866
71	RNA degradation_Homo sapiens_hsa03018	0.94345993
72	Folate biosynthesis_Homo sapiens_hsa00790	0.93495840
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.93127722
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92743266
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.90116095
76	Purine metabolism_Homo sapiens_hsa00230	0.88081923
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.85693231
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.77833146
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76464219
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76129070
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66619914
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58427961
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55239746
84	Nitrogen metabolism_Homo sapiens_hsa00910	0.55157164
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54810917
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51132473
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50193608
88	Nicotine addiction_Homo sapiens_hsa05033	0.49758411
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.47926625
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47037986
91	Cell cycle_Homo sapiens_hsa04110	0.44989341
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.43784360
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43261259
94	Regulation of autophagy_Homo sapiens_hsa04140	0.41105385
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40339731
96	Complement and coagulation cascades_Homo sapiens_hsa04610	0.37095711
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.36914032
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36199001
99	Galactose metabolism_Homo sapiens_hsa00052	0.35367673
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34746608

ALG1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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