ALG1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)4.54141683
2cullin deneddylation (GO:0010388)4.13682361
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07494814
4epithelial cilium movement (GO:0003351)4.06423304
5proteasome assembly (GO:0043248)4.03710671
6base-excision repair, AP site formation (GO:0006285)3.98661358
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.96470316
8cilium movement (GO:0003341)3.84074207
9glyoxylate metabolic process (GO:0046487)3.83171419
10ATP synthesis coupled proton transport (GO:0015986)3.81013380
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81013380
12protein deneddylation (GO:0000338)3.80189672
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73318395
14aldehyde catabolic process (GO:0046185)3.66775554
15protein complex biogenesis (GO:0070271)3.63020112
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.57745308
17NADH dehydrogenase complex assembly (GO:0010257)3.57745308
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57745308
19positive regulation of mitochondrial fission (GO:0090141)3.54372248
20GTP biosynthetic process (GO:0006183)3.48268015
21chaperone-mediated protein transport (GO:0072321)3.48059361
22motile cilium assembly (GO:0044458)3.47251686
23mitochondrial respiratory chain complex assembly (GO:0033108)3.43156565
24protein-cofactor linkage (GO:0018065)3.38720718
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37898501
26electron transport chain (GO:0022900)3.37777111
27respiratory electron transport chain (GO:0022904)3.34654789
28respiratory chain complex IV assembly (GO:0008535)3.30772129
29cilium or flagellum-dependent cell motility (GO:0001539)3.30477793
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22406189
31regulation of cellular amino acid metabolic process (GO:0006521)3.17620827
32DNA double-strand break processing (GO:0000729)3.12717767
33peptidyl-histidine modification (GO:0018202)3.11984708
34ubiquinone biosynthetic process (GO:0006744)3.11285479
35intraciliary transport (GO:0042073)3.11074372
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11014447
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11014447
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10778688
39regulation of mitochondrial translation (GO:0070129)3.10643393
40axoneme assembly (GO:0035082)3.07956076
41phenylpropanoid metabolic process (GO:0009698)3.05277683
42UTP biosynthetic process (GO:0006228)3.02735786
43pseudouridine synthesis (GO:0001522)3.02524727
44L-methionine salvage (GO:0071267)3.01861155
45L-methionine biosynthetic process (GO:0071265)3.01861155
46amino acid salvage (GO:0043102)3.01861155
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01649276
48cytochrome complex assembly (GO:0017004)2.97401878
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93983162
50mannosylation (GO:0097502)2.93460821
51ubiquinone metabolic process (GO:0006743)2.93049153
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92529047
53protein neddylation (GO:0045116)2.92495394
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90326408
55negative regulation of ligase activity (GO:0051352)2.89000087
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89000087
57histone H2A acetylation (GO:0043968)2.88309463
58oxidative phosphorylation (GO:0006119)2.86994005
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83922205
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83922205
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83922205
62nucleoside diphosphate phosphorylation (GO:0006165)2.82744868
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.82680650
64termination of RNA polymerase III transcription (GO:0006386)2.82680650
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80119413
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80119413
67UTP metabolic process (GO:0046051)2.78580670
68sequestering of actin monomers (GO:0042989)2.78193526
69protein targeting to mitochondrion (GO:0006626)2.78036812
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78015028
71peptidyl-arginine N-methylation (GO:0035246)2.77636695
72peptidyl-arginine methylation (GO:0018216)2.77636695
73CTP biosynthetic process (GO:0006241)2.77623310
74CTP metabolic process (GO:0046036)2.77623310
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77259197
76C-terminal protein lipidation (GO:0006501)2.77087205
77branched-chain amino acid catabolic process (GO:0009083)2.77069228
78metallo-sulfur cluster assembly (GO:0031163)2.76542471
79iron-sulfur cluster assembly (GO:0016226)2.76542471
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.75864538
81C-terminal protein amino acid modification (GO:0018410)2.74700087
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74090578
83protein localization to mitochondrion (GO:0070585)2.73603278
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.73029606
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73029606
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67089872
87water-soluble vitamin biosynthetic process (GO:0042364)2.66752480
88guanosine-containing compound biosynthetic process (GO:1901070)2.66726524
89pyrimidine nucleotide catabolic process (GO:0006244)2.66033775
90serine family amino acid catabolic process (GO:0009071)2.64132924
91establishment of protein localization to mitochondrion (GO:0072655)2.63573413
92DNA damage response, detection of DNA damage (GO:0042769)2.63456608
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.60897894
94intracellular protein transmembrane import (GO:0044743)2.60896890
95rRNA modification (GO:0000154)2.60485044
96preassembly of GPI anchor in ER membrane (GO:0016254)2.60257806
97left/right pattern formation (GO:0060972)2.59818954
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59648553
99quinone biosynthetic process (GO:1901663)2.55893928
100ATP biosynthetic process (GO:0006754)2.55829874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57076584
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46388910
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.22267839
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.89629939
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.60480493
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56308385
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17620962
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.92919438
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71287146
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58569264
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34161459
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32258970
13VDR_23849224_ChIP-Seq_CD4+_Human2.26688439
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21405060
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.19540076
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.18953452
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17615339
18IGF1R_20145208_ChIP-Seq_DFB_Human2.17417363
19ZNF274_21170338_ChIP-Seq_K562_Hela2.16550412
20GABP_19822575_ChIP-Seq_HepG2_Human2.01648693
21VDR_22108803_ChIP-Seq_LS180_Human1.99360264
22ELK1_19687146_ChIP-ChIP_HELA_Human1.97996183
23DCP1A_22483619_ChIP-Seq_HELA_Human1.96237089
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96064636
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94738280
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93915386
27FOXP3_21729870_ChIP-Seq_TREG_Human1.89226620
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84454434
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83706474
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75786354
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73157013
32IRF1_19129219_ChIP-ChIP_H3396_Human1.70661191
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70006250
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69479419
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67894360
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63027674
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61771686
38MYC_18940864_ChIP-ChIP_HL60_Human1.59680463
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56484090
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49301560
41XRN2_22483619_ChIP-Seq_HELA_Human1.48757903
42HTT_18923047_ChIP-ChIP_STHdh_Human1.48473168
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45186849
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44944110
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43773748
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43368121
47TTF2_22483619_ChIP-Seq_HELA_Human1.42492600
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.41832424
49EWS_26573619_Chip-Seq_HEK293_Human1.39005064
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37486252
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34219618
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32166462
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31345632
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27801546
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22527518
56ER_23166858_ChIP-Seq_MCF-7_Human1.21830775
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21497916
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21216635
59AR_20517297_ChIP-Seq_VCAP_Human1.15988560
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14641108
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13396200
62FUS_26573619_Chip-Seq_HEK293_Human1.12149169
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11325677
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09559921
65GBX2_23144817_ChIP-Seq_PC3_Human1.08927214
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08674032
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06735900
68TP53_22573176_ChIP-Seq_HFKS_Human1.05620839
69KDM5A_27292631_Chip-Seq_BREAST_Human1.04662446
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03565250
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03528407
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02276949
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.02056131
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01987162
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01057745
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.00635858
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98996170
78NCOR_22424771_ChIP-Seq_293T_Human0.98570758
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.98099246
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98099246
81MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97153653
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91492984
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91309580
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89448678
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89337695
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.88200905
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.87994368
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.87452650
89HOXB7_26014856_ChIP-Seq_BT474_Human0.86974096
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85472421
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84743186
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83662301
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82839498
94* ERA_21632823_ChIP-Seq_H3396_Human0.82170073
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.81252125
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81194694
97TAF15_26573619_Chip-Seq_HEK293_Human0.80849853
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80553921
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80361824
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80131411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.10686291
2MP0008875_abnormal_xenobiotic_pharmacok2.83774574
3MP0008058_abnormal_DNA_repair2.77642672
4MP0003806_abnormal_nucleotide_metabolis2.71665341
5MP0009697_abnormal_copulation2.66199262
6MP0005085_abnormal_gallbladder_physiolo2.39303935
7MP0003195_calcinosis2.26038958
8MP0008789_abnormal_olfactory_epithelium2.12641847
9MP0000372_irregular_coat_pigmentation2.09027969
10MP0006072_abnormal_retinal_apoptosis1.97430604
11MP0002653_abnormal_ependyma_morphology1.97151045
12MP0005365_abnormal_bile_salt1.93085063
13MP0004133_heterotaxia1.92518637
14MP0001529_abnormal_vocalization1.88445142
15MP0001764_abnormal_homeostasis1.87328663
16MP0006036_abnormal_mitochondrial_physio1.85880387
17MP0008995_early_reproductive_senescence1.75499383
18MP0006035_abnormal_mitochondrial_morpho1.71804659
19MP0005394_taste/olfaction_phenotype1.69375448
20MP0005499_abnormal_olfactory_system1.69375448
21MP0003693_abnormal_embryo_hatching1.68568990
22MP0008877_abnormal_DNA_methylation1.65830934
23MP0002837_dystrophic_cardiac_calcinosis1.60872179
24MP0003186_abnormal_redox_activity1.59728520
25MP0005360_urolithiasis1.56365373
26MP0002876_abnormal_thyroid_physiology1.54039350
27MP0005253_abnormal_eye_physiology1.53332036
28MP0010030_abnormal_orbit_morphology1.52228441
29MP0000566_synostosis1.50902935
30MP0002234_abnormal_pharynx_morphology1.49981081
31MP0000049_abnormal_middle_ear1.49567996
32MP0002139_abnormal_hepatobiliary_system1.48778214
33MP0003718_maternal_effect1.44823290
34MP0003786_premature_aging1.44165737
35MP0010094_abnormal_chromosome_stability1.44119366
36MP0005083_abnormal_biliary_tract1.42663236
37MP0008932_abnormal_embryonic_tissue1.36507155
38MP0005551_abnormal_eye_electrophysiolog1.36016579
39MP0004147_increased_porphyrin_level1.35857928
40MP0003011_delayed_dark_adaptation1.34480432
41MP0001984_abnormal_olfaction1.33474791
42MP0002736_abnormal_nociception_after1.33323365
43MP0009046_muscle_twitch1.33322334
44MP0005187_abnormal_penis_morphology1.31753271
45MP0000383_abnormal_hair_follicle1.31287853
46MP0005646_abnormal_pituitary_gland1.28837220
47MP0008872_abnormal_physiological_respon1.27488028
48MP0002160_abnormal_reproductive_system1.23047789
49MP0002751_abnormal_autonomic_nervous1.21128491
50MP0004957_abnormal_blastocyst_morpholog1.20503723
51MP0010386_abnormal_urinary_bladder1.20085680
52MP0004270_analgesia1.15000855
53MP0002249_abnormal_larynx_morphology1.14693427
54MP0002822_catalepsy1.13645413
55MP0002282_abnormal_trachea_morphology1.12761953
56MP0003880_abnormal_central_pattern1.12517957
57MP0001346_abnormal_lacrimal_gland1.10225940
58MP0002090_abnormal_vision1.10218867
59MP0005332_abnormal_amino_acid1.08935807
60MP0000631_abnormal_neuroendocrine_gland1.08890243
61MP0006292_abnormal_olfactory_placode1.04763154
62MP0003937_abnormal_limbs/digits/tail_de1.03288200
63MP0003136_yellow_coat_color1.02363729
64MP0002132_abnormal_respiratory_system1.01641884
65MP0004019_abnormal_vitamin_homeostasis1.01298089
66MP0006276_abnormal_autonomic_nervous1.00544911
67MP0003938_abnormal_ear_development1.00455566
68MP0003137_abnormal_impulse_conducting0.99621386
69MP0000647_abnormal_sebaceous_gland0.99293780
70MP0003121_genomic_imprinting0.97723979
71MP0002233_abnormal_nose_morphology0.97033367
72MP0001293_anophthalmia0.96478853
73MP0001929_abnormal_gametogenesis0.96103403
74MP0003221_abnormal_cardiomyocyte_apopto0.91388744
75MP0003122_maternal_imprinting0.90856863
76MP0002254_reproductive_system_inflammat0.90577228
77MP0003315_abnormal_perineum_morphology0.90268586
78MP0002138_abnormal_hepatobiliary_system0.90196119
79MP0001485_abnormal_pinna_reflex0.88772228
80MP0004043_abnormal_pH_regulation0.87469961
81MP0001968_abnormal_touch/_nociception0.86976573
82MP0003698_abnormal_male_reproductive0.86852325
83MP0002098_abnormal_vibrissa_morphology0.85961240
84MP0003077_abnormal_cell_cycle0.85626944
85MP0002210_abnormal_sex_determination0.85271651
86MP0005645_abnormal_hypothalamus_physiol0.85268121
87MP0003787_abnormal_imprinting0.84898370
88MP0005636_abnormal_mineral_homeostasis0.84032504
89MP0003111_abnormal_nucleus_morphology0.82712700
90MP0009745_abnormal_behavioral_response0.81903687
91MP0000653_abnormal_sex_gland0.81841292
92MP0005391_vision/eye_phenotype0.81189301
93MP0001905_abnormal_dopamine_level0.81181609
94MP0005379_endocrine/exocrine_gland_phen0.79374661
95MP0004215_abnormal_myocardial_fiber0.74146925
96MP0001145_abnormal_male_reproductive0.74132288
97MP0002909_abnormal_adrenal_gland0.70267955
98MP0003252_abnormal_bile_duct0.69873914
99MP0002277_abnormal_respiratory_mucosa0.69080370
100MP0005395_other_phenotype0.68943528

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.33429117
2Abnormal respiratory epithelium morphology (HP:0012253)4.18040904
3Abnormal respiratory motile cilium morphology (HP:0005938)4.18040904
4Abnormal respiratory motile cilium physiology (HP:0012261)4.10541682
5Abnormal ciliary motility (HP:0012262)3.89992173
6Acute necrotizing encephalopathy (HP:0006965)3.85608664
7Rhinitis (HP:0012384)3.83653570
8Acute encephalopathy (HP:0006846)3.62008776
9Abnormal mitochondria in muscle tissue (HP:0008316)3.55563865
10Pancreatic cysts (HP:0001737)3.51505729
11Mitochondrial inheritance (HP:0001427)3.42604101
12Pancreatic fibrosis (HP:0100732)3.41828767
13True hermaphroditism (HP:0010459)3.35696493
14Increased CSF lactate (HP:0002490)3.33136347
15Absent/shortened dynein arms (HP:0200106)3.29402770
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.29402770
17Chronic bronchitis (HP:0004469)3.17154722
18Hepatocellular necrosis (HP:0001404)3.16498575
19Progressive macrocephaly (HP:0004481)3.00991301
20Hepatic necrosis (HP:0002605)2.97994320
21Cerebral edema (HP:0002181)2.95277009
22Molar tooth sign on MRI (HP:0002419)2.93830571
23Abnormality of midbrain morphology (HP:0002418)2.93830571
243-Methylglutaconic aciduria (HP:0003535)2.84976627
25Medial flaring of the eyebrow (HP:0010747)2.78855828
26Delayed CNS myelination (HP:0002188)2.76771688
27Nephrogenic diabetes insipidus (HP:0009806)2.72520744
28Congenital primary aphakia (HP:0007707)2.71078457
29Nephronophthisis (HP:0000090)2.65984611
30Gait imbalance (HP:0002141)2.65949772
31Occipital encephalocele (HP:0002085)2.54219803
32Lactic acidosis (HP:0003128)2.54033230
33Type I transferrin isoform profile (HP:0003642)2.50382791
34Increased serum lactate (HP:0002151)2.46532582
35Bile duct proliferation (HP:0001408)2.45010615
36Abnormal biliary tract physiology (HP:0012439)2.45010615
37Cystic liver disease (HP:0006706)2.44634488
38Renal Fanconi syndrome (HP:0001994)2.38970461
39Sclerocornea (HP:0000647)2.34708517
40Lipid accumulation in hepatocytes (HP:0006561)2.34422865
41Methylmalonic aciduria (HP:0012120)2.34312943
42Lethargy (HP:0001254)2.30598027
43Anencephaly (HP:0002323)2.28205646
44Respiratory failure (HP:0002878)2.27613698
45Bronchiectasis (HP:0002110)2.26139319
46Abnormal protein glycosylation (HP:0012346)2.24283707
47Abnormal glycosylation (HP:0012345)2.24283707
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24283707
49Abnormal protein N-linked glycosylation (HP:0012347)2.24283707
50Increased hepatocellular lipid droplets (HP:0006565)2.22364105
51Generalized aminoaciduria (HP:0002909)2.20253158
52Postaxial foot polydactyly (HP:0001830)2.19321692
53Vaginal atresia (HP:0000148)2.18019894
54Reduced antithrombin III activity (HP:0001976)2.16264781
55Concave nail (HP:0001598)2.13876813
56Genital tract atresia (HP:0001827)2.13733890
57Abnormality of glycine metabolism (HP:0010895)2.13623149
58Abnormality of serine family amino acid metabolism (HP:0010894)2.13623149
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.12246483
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11921265
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11921265
62Hyperglycinemia (HP:0002154)2.08986190
63Prolonged partial thromboplastin time (HP:0003645)2.07027903
64Abnormality of the renal medulla (HP:0100957)2.06460820
65Limb dystonia (HP:0002451)2.06371963
66Optic disc pallor (HP:0000543)2.04509591
67Hyperglycinuria (HP:0003108)2.02732434
68Abnormality of the labia minora (HP:0012880)1.99168442
69Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93962204
70Intestinal atresia (HP:0011100)1.93482663
71Preaxial hand polydactyly (HP:0001177)1.93084050
72Exercise intolerance (HP:0003546)1.89160938
73Methylmalonic acidemia (HP:0002912)1.84915533
74Glycosuria (HP:0003076)1.83963218
75Abnormality of urine glucose concentration (HP:0011016)1.83963218
76Male pseudohermaphroditism (HP:0000037)1.81844327
77Abnormality of serum amino acid levels (HP:0003112)1.81401521
78Chronic hepatic failure (HP:0100626)1.81373959
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.80167385
80Colon cancer (HP:0003003)1.79889713
81X-linked dominant inheritance (HP:0001423)1.78386104
82Asplenia (HP:0001746)1.77801717
83Abnormality of pyrimidine metabolism (HP:0004353)1.76902827
84Leukodystrophy (HP:0002415)1.76678791
85Congenital hepatic fibrosis (HP:0002612)1.76110743
86Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75296885
87Hyperphosphaturia (HP:0003109)1.72728371
88Postaxial hand polydactyly (HP:0001162)1.71494871
89Dicarboxylic aciduria (HP:0003215)1.71165171
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71165171
91Thyroid-stimulating hormone excess (HP:0002925)1.69609719
92Hyperammonemia (HP:0001987)1.69451088
93Increased intramyocellular lipid droplets (HP:0012240)1.68085261
94Tubulointerstitial nephritis (HP:0001970)1.67984133
95Intrahepatic cholestasis (HP:0001406)1.66781779
96Poor coordination (HP:0002370)1.66266787
97Renal cortical cysts (HP:0000803)1.65713428
98Abnormality of the renal cortex (HP:0011035)1.65290825
99Ketosis (HP:0001946)1.64987438
100Decreased testicular size (HP:0008734)1.64522472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.59015434
2MAP4K23.14551934
3SRPK13.08572213
4NME12.82402833
5PBK2.81158156
6TRIM282.64479053
7BCKDK2.62136490
8STK162.55189322
9BUB12.47616889
10ZAK2.43788348
11MAP3K42.22673707
12CSNK1G32.09418381
13BCR1.99291281
14NUAK11.97346495
15ERBB31.96186335
16MUSK1.92919961
17CSNK1G11.87166526
18CSNK1G21.85561194
19WNK31.83548514
20CSNK1A1L1.80469851
21VRK11.74032277
22MAP2K71.67063480
23GRK11.51768257
24MST41.46411598
25TSSK61.42219423
26EPHA21.38244047
27TESK21.36637847
28EPHA41.33889998
29MST1R1.32606857
30PINK11.32236944
31MAP3K121.27198593
32TTK1.26390761
33DYRK21.24821378
34MAPK151.19641033
35PLK31.16171321
36LIMK11.15910571
37PLK41.12105412
38BRSK11.10993188
39ADRBK21.08930353
40MAPKAPK31.02924713
41DYRK31.02780527
42DAPK11.02395905
43NME21.01689064
44CASK1.00984620
45STK38L0.98328453
46PLK10.97477146
47MAPK130.96705573
48KDR0.94264867
49CDK80.92717916
50INSRR0.92002406
51BRSK20.91650102
52NEK10.90840744
53OXSR10.87237216
54PRKCI0.86825316
55TESK10.83298248
56PDK20.82387359
57CDK190.81941839
58AURKA0.81159993
59RPS6KA40.80017574
60EIF2AK30.77294933
61ATR0.75727139
62TAF10.66685794
63AURKB0.63563915
64MINK10.60911064
65EIF2AK10.60796039
66GRK50.60665510
67CHEK20.60155045
68CSNK2A10.59362541
69TLK10.58928616
70FRK0.58577215
71CSNK1A10.56791047
72STK390.56750440
73MAP3K50.56679076
74PRKCE0.55039417
75PHKG10.54366662
76PHKG20.54366662
77EIF2AK20.52086980
78MAP2K40.51725820
79UHMK10.50688568
80CAMK2A0.48784238
81PRKCG0.48402550
82CAMK2B0.47819051
83RPS6KA50.47036371
84CSNK2A20.46649152
85CDC70.46312701
86OBSCN0.44943871
87PASK0.44566471
88CCNB10.44514449
89CAMK2G0.44174915
90MARK10.40045807
91CDK90.39868515
92CDK70.39423899
93WEE10.37710728
94DYRK1A0.37420896
95PRKACB0.35963637
96PRKACA0.35757620
97CSNK1E0.34598783
98ATM0.34517910
99PIM20.33912961
100PAK30.33172650

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.35662490
2Oxidative phosphorylation_Homo sapiens_hsa001902.82390246
3Parkinsons disease_Homo sapiens_hsa050122.43251599
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.16277305
5RNA polymerase_Homo sapiens_hsa030202.12783354
6Huntingtons disease_Homo sapiens_hsa050162.11939089
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10676630
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99590716
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99079659
10Base excision repair_Homo sapiens_hsa034101.90747467
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83889374
12Mismatch repair_Homo sapiens_hsa034301.82725942
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80889009
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77326566
15Fatty acid elongation_Homo sapiens_hsa000621.72778434
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67237126
17Chemical carcinogenesis_Homo sapiens_hsa052041.66976223
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61429641
19Propanoate metabolism_Homo sapiens_hsa006401.59871505
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59438540
21Phenylalanine metabolism_Homo sapiens_hsa003601.59260011
22DNA replication_Homo sapiens_hsa030301.56641465
23Alzheimers disease_Homo sapiens_hsa050101.56336871
24Peroxisome_Homo sapiens_hsa041461.52052104
25Sulfur relay system_Homo sapiens_hsa041221.52020302
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.51048874
27Homologous recombination_Homo sapiens_hsa034401.44248727
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.42358067
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42182426
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41445497
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41214462
32Retinol metabolism_Homo sapiens_hsa008301.40886924
33Pyrimidine metabolism_Homo sapiens_hsa002401.39631351
34beta-Alanine metabolism_Homo sapiens_hsa004101.39236162
35Butanoate metabolism_Homo sapiens_hsa006501.38493702
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36569841
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36552906
38Protein export_Homo sapiens_hsa030601.35484049
39Ribosome_Homo sapiens_hsa030101.34341555
40Non-homologous end-joining_Homo sapiens_hsa034501.25858219
41Steroid biosynthesis_Homo sapiens_hsa001001.21923966
42Biosynthesis of amino acids_Homo sapiens_hsa012301.21879432
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.21316603
44Spliceosome_Homo sapiens_hsa030401.19520540
45Fanconi anemia pathway_Homo sapiens_hsa034601.19282334
46Glutathione metabolism_Homo sapiens_hsa004801.19100109
47Arginine biosynthesis_Homo sapiens_hsa002201.18012520
48Arginine and proline metabolism_Homo sapiens_hsa003301.16122789
49Tyrosine metabolism_Homo sapiens_hsa003501.15961911
50Pyruvate metabolism_Homo sapiens_hsa006201.15692653
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15378348
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14704541
53Linoleic acid metabolism_Homo sapiens_hsa005911.14405957
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14309528
55Basal transcription factors_Homo sapiens_hsa030221.14133458
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14113364
57Carbon metabolism_Homo sapiens_hsa012001.11968143
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10701316
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08491613
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04640759
61RNA transport_Homo sapiens_hsa030131.04547500
62Sulfur metabolism_Homo sapiens_hsa009201.03695915
63Fatty acid degradation_Homo sapiens_hsa000711.02912739
64Caffeine metabolism_Homo sapiens_hsa002321.01709297
65Tryptophan metabolism_Homo sapiens_hsa003800.99839449
66Metabolic pathways_Homo sapiens_hsa011000.99251366
67Phototransduction_Homo sapiens_hsa047440.98697226
68Histidine metabolism_Homo sapiens_hsa003400.98548032
69Cardiac muscle contraction_Homo sapiens_hsa042600.96615659
70One carbon pool by folate_Homo sapiens_hsa006700.94952866
71RNA degradation_Homo sapiens_hsa030180.94345993
72Folate biosynthesis_Homo sapiens_hsa007900.93495840
73Nucleotide excision repair_Homo sapiens_hsa034200.93127722
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92743266
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90116095
76Purine metabolism_Homo sapiens_hsa002300.88081923
77Vitamin B6 metabolism_Homo sapiens_hsa007500.85693231
78Fatty acid metabolism_Homo sapiens_hsa012120.77833146
79Collecting duct acid secretion_Homo sapiens_hsa049660.76464219
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.76129070
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66619914
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.58427961
83Pentose phosphate pathway_Homo sapiens_hsa000300.55239746
84Nitrogen metabolism_Homo sapiens_hsa009100.55157164
85N-Glycan biosynthesis_Homo sapiens_hsa005100.54810917
86Arachidonic acid metabolism_Homo sapiens_hsa005900.51132473
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50193608
88Nicotine addiction_Homo sapiens_hsa050330.49758411
89Fructose and mannose metabolism_Homo sapiens_hsa000510.47926625
90Starch and sucrose metabolism_Homo sapiens_hsa005000.47037986
91Cell cycle_Homo sapiens_hsa041100.44989341
92Selenocompound metabolism_Homo sapiens_hsa004500.43784360
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43261259
94Regulation of autophagy_Homo sapiens_hsa041400.41105385
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40339731
96Complement and coagulation cascades_Homo sapiens_hsa046100.37095711
97Fat digestion and absorption_Homo sapiens_hsa049750.36914032
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36199001
99Galactose metabolism_Homo sapiens_hsa000520.35367673
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34746608

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