ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	6.37389203
2	platelet dense granule organization (GO:0060155)	6.31145809
3	neuron remodeling (GO:0016322)	5.41937684
4	regulation of pigment cell differentiation (GO:0050932)	5.29715437
5	response to nitrosative stress (GO:0051409)	5.28698444
6	formation of translation preinitiation complex (GO:0001731)	5.20006483
7	forebrain morphogenesis (GO:0048853)	5.18737472
8	purine nucleobase biosynthetic process (GO:0009113)	5.05527651
9	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.71734979
10	neural tube formation (GO:0001841)	4.42539731
11	IMP biosynthetic process (GO:0006188)	4.33843895
12	cobalamin metabolic process (GO:0009235)	4.31798533
13	negative regulation of neurotransmitter secretion (GO:0046929)	4.16547878
14	homocysteine metabolic process (GO:0050667)	4.05246392
15	negative regulation of neurotransmitter transport (GO:0051589)	4.00192657
16	double-strand break repair via nonhomologous end joining (GO:0006303)	3.99943582
17	non-recombinational repair (GO:0000726)	3.99943582
18	purine nucleotide salvage (GO:0032261)	3.98227325
19	striatum development (GO:0021756)	3.98035245
20	presynaptic membrane assembly (GO:0097105)	3.95867386
21	nonmotile primary cilium assembly (GO:0035058)	3.93807602
22	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.82165449
23	parental behavior (GO:0060746)	3.75497330
24	auditory receptor cell differentiation (GO:0042491)	3.66591139
25	nucleobase biosynthetic process (GO:0046112)	3.61229352
26	maternal behavior (GO:0042711)	3.54985290
27	photoreceptor cell maintenance (GO:0045494)	3.53953828
28	forebrain neuron development (GO:0021884)	3.51331825
29	IMP metabolic process (GO:0046040)	3.41958209
30	telomere maintenance via recombination (GO:0000722)	3.41750313
31	translesion synthesis (GO:0019985)	3.35841885
32	stress granule assembly (GO:0034063)	3.28122101
33	regulation of RNA export from nucleus (GO:0046831)	3.25426479
34	resolution of meiotic recombination intermediates (GO:0000712)	3.24822426
35	negative regulation of translational initiation (GO:0045947)	3.24426099
36	presynaptic membrane organization (GO:0097090)	3.20801435
37	ribosomal small subunit assembly (GO:0000028)	3.20569410
38	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.20333406
39	regulation of meiosis I (GO:0060631)	3.18631017
40	negative regulation of epidermal cell differentiation (GO:0045605)	3.16613674
41	positive regulation of T cell differentiation in thymus (GO:0033089)	3.15958394
42	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.15593114
43	CTP metabolic process (GO:0046036)	3.14173721
44	CTP biosynthetic process (GO:0006241)	3.14173721
45	postsynaptic membrane organization (GO:0001941)	3.13923006
46	folic acid metabolic process (GO:0046655)	3.10754174
47	central nervous system neuron development (GO:0021954)	3.08306038
48	retinal cone cell development (GO:0046549)	3.01915715
49	ubiquinone metabolic process (GO:0006743)	3.01371474
50	cholesterol biosynthetic process (GO:0006695)	2.97761960
51	folic acid transport (GO:0015884)	2.95381731
52	lateral ventricle development (GO:0021670)	2.92575384
53	transcription-coupled nucleotide-excision repair (GO:0006283)	2.89557053
54	respiratory chain complex IV assembly (GO:0008535)	2.87002569
55	negative regulation of granulocyte differentiation (GO:0030853)	2.84646847
56	tRNA aminoacylation (GO:0043039)	2.80800776
57	amino acid activation (GO:0043038)	2.80800776
58	GMP metabolic process (GO:0046037)	2.79441385
59	regulation of action potential (GO:0098900)	2.78909061
60	tRNA aminoacylation for protein translation (GO:0006418)	2.78887373
61	glycerol ether metabolic process (GO:0006662)	2.76457917
62	otic vesicle formation (GO:0030916)	2.75406475
63	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.74468939
64	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.74468939
65	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.74468939
66	positive regulation of muscle cell apoptotic process (GO:0010661)	2.72894162
67	mitotic recombination (GO:0006312)	2.72143338
68	regulation of sister chromatid cohesion (GO:0007063)	2.71250698
69	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.69855026
70	transcription from mitochondrial promoter (GO:0006390)	2.69601538
71	protein complex biogenesis (GO:0070271)	2.69043515
72	anterograde synaptic vesicle transport (GO:0048490)	2.67426724
73	peptidyl-arginine N-methylation (GO:0035246)	2.64787471
74	peptidyl-arginine methylation (GO:0018216)	2.64787471
75	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.64168425
76	ubiquinone biosynthetic process (GO:0006744)	2.62715297
77	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.62036657
78	ether metabolic process (GO:0018904)	2.61655685
79	regulation of penile erection (GO:0060405)	2.60069633
80	negative regulation of circadian rhythm (GO:0042754)	2.58386593
81	response to xenobiotic stimulus (GO:0009410)	2.57182406
82	amino acid salvage (GO:0043102)	2.56608603
83	L-methionine salvage (GO:0071267)	2.56608603
84	L-methionine biosynthetic process (GO:0071265)	2.56608603
85	cytochrome complex assembly (GO:0017004)	2.55979822
86	glutamine metabolic process (GO:0006541)	2.54331280
87	telomere maintenance via semi-conservative replication (GO:0032201)	2.54214845
88	N-terminal protein amino acid acetylation (GO:0006474)	2.53412195
89	sterol biosynthetic process (GO:0016126)	2.50860103
90	positive regulation of neurotransmitter secretion (GO:0001956)	2.50840499
91	localization within membrane (GO:0051668)	2.50728837
92	sequestering of actin monomers (GO:0042989)	2.50652292
93	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.47859763
94	cerebral cortex neuron differentiation (GO:0021895)	2.46633863
95	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	2.44741610
96	seminiferous tubule development (GO:0072520)	2.44174101
97	fucose metabolic process (GO:0006004)	2.41713538
98	ribosomal large subunit biogenesis (GO:0042273)	2.41574193
99	cellular ketone body metabolic process (GO:0046950)	11.9640087
100	ketone body metabolic process (GO:1902224)	10.6156696

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.34167981
2	VDR_22108803_ChIP-Seq_LS180_Human	3.62551549
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.50013082
4	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.58826931
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.55849943
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46007611
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45009477
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40091494
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27394928
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25868934
11	FUS_26573619_Chip-Seq_HEK293_Human	2.24884574
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18824843
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15901737
14	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10594955
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.06696283
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00581648
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.96380190
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95491764
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.88773241
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.88227340
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81669455
22	EWS_26573619_Chip-Seq_HEK293_Human	1.79068534
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.73254888
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72700038
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70936778
26	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.70709263
27	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66247324
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.64755127
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.64281310
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.62488227
31	HTT_18923047_ChIP-ChIP_STHdh_Human	1.62139302
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.58870298
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.58678199
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56133048
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56061592
36	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.55902262
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54622072
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.53577614
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53476471
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52577202
41	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.51761832
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49675105
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48456687
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46464285
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40868493
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40141500
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38137406
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37831190
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37648756
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37177521
51	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.37113960
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.36846013
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.34435189
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32979972
55	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31541203
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27322366
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26566090
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.26033680
59	P300_19829295_ChIP-Seq_ESCs_Human	1.25549931
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.24066835
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23352122
62	GABP_19822575_ChIP-Seq_HepG2_Human	1.23032097
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22565106
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22339224
65	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22165196
66	NCOR_22424771_ChIP-Seq_293T_Human	1.21878047
67	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.21648037
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20573804
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19652057
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17595140
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17595140
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.16904416
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15792627
74	AR_20517297_ChIP-Seq_VCAP_Human	1.15077768
75	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.13681905
76	XRN2_22483619_ChIP-Seq_HELA_Human	1.13071645
77	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.12896921
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10935968
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10685830
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09410799
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08386881
82	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06802768
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06542658
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05044269
85	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04431673
86	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.03450975
87	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02033831
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01573704
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00665341
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00583183
91	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00286292
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99773690
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97087587
94	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97004042
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96285729
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96055400
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96033027
98	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95300584
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95227011
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95227011

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	9.17712031
2	MP0001188_hyperpigmentation	4.44359613
3	MP0005409_darkened_coat_color	3.43411817
4	MP0001529_abnormal_vocalization	3.07367193
5	MP0001984_abnormal_olfaction	3.02586379
6	MP0005174_abnormal_tail_pigmentation	2.97271717
7	MP0001764_abnormal_homeostasis	2.63178290
8	MP0003136_yellow_coat_color	2.57605331
9	MP0006276_abnormal_autonomic_nervous	2.55176209
10	MP0003880_abnormal_central_pattern	2.46731114
11	MP0006072_abnormal_retinal_apoptosis	2.45546644
12	MP0004043_abnormal_pH_regulation	2.33879536
13	MP0002837_dystrophic_cardiac_calcinosis	2.22155745
14	MP0010386_abnormal_urinary_bladder	2.13686338
15	MP0008058_abnormal_DNA_repair	1.94458814
16	MP0004484_altered_response_of	1.85213149
17	MP0005075_abnormal_melanosome_morpholog	1.78833015
18	MP0002009_preneoplasia	1.78427277
19	MP0003567_abnormal_fetal_cardiomyocyte	1.75281120
20	MP0004885_abnormal_endolymph	1.75166083
21	MP0008789_abnormal_olfactory_epithelium	1.65309924
22	MP0005253_abnormal_eye_physiology	1.65205810
23	MP0000015_abnormal_ear_pigmentation	1.55745026
24	MP0005551_abnormal_eye_electrophysiolog	1.49239539
25	MP0002736_abnormal_nociception_after	1.49064756
26	MP0001968_abnormal_touch/_nociception	1.47507929
27	MP0005394_taste/olfaction_phenotype	1.47068208
28	MP0005499_abnormal_olfactory_system	1.47068208
29	MP0005423_abnormal_somatic_nervous	1.45713446
30	MP0004215_abnormal_myocardial_fiber	1.44867211
31	MP0000372_irregular_coat_pigmentation	1.42695173
32	MP0002638_abnormal_pupillary_reflex	1.39635111
33	MP0002234_abnormal_pharynx_morphology	1.37994504
34	MP0000383_abnormal_hair_follicle	1.34979483
35	MP0002127_abnormal_cardiovascular_syste	1.33638204
36	MP0002095_abnormal_skin_pigmentation	1.31425186
37	MP0009697_abnormal_copulation	1.26495734
38	MP0001324_abnormal_eye_pigmentation	1.16649586
39	MP0005171_absent_coat_pigmentation	1.14051661
40	MP0003221_abnormal_cardiomyocyte_apopto	1.11774477
41	MP0003724_increased_susceptibility_to	1.11177726
42	MP0004782_abnormal_surfactant_physiolog	1.10921668
43	MP0002734_abnormal_mechanical_nocicepti	1.09631214
44	MP0002184_abnormal_innervation	1.05947875
45	MP0003119_abnormal_digestive_system	1.05258055
46	MP0002272_abnormal_nervous_system	1.04074328
47	MP0001177_atelectasis	1.02907456
48	MP0001905_abnormal_dopamine_level	1.01716676
49	MP0004084_abnormal_cardiac_muscle	0.99568216
50	MP0003183_abnormal_peptide_metabolism	0.98613688
51	MP0000778_abnormal_nervous_system	0.98120968
52	MP0002102_abnormal_ear_morphology	0.96027652
53	MP0010094_abnormal_chromosome_stability	0.95437924
54	MP0005195_abnormal_posterior_eye	0.93434739
55	MP0004147_increased_porphyrin_level	0.93219268
56	MP0000538_abnormal_urinary_bladder	0.91212239
57	MP0000049_abnormal_middle_ear	0.89913132
58	MP0001664_abnormal_digestion	0.87499563
59	MP0002233_abnormal_nose_morphology	0.86620817
60	MP0010368_abnormal_lymphatic_system	0.85829745
61	MP0005085_abnormal_gallbladder_physiolo	0.84686437
62	MP0003252_abnormal_bile_duct	0.84248662
63	MP0010678_abnormal_skin_adnexa	0.83156989
64	MP0002938_white_spotting	0.82737629
65	MP0009745_abnormal_behavioral_response	0.82580863
66	MP0005645_abnormal_hypothalamus_physiol	0.81740327
67	MP0005620_abnormal_muscle_contractility	0.81192857
68	MP0002295_abnormal_pulmonary_circulatio	0.79626565
69	MP0009384_cardiac_valve_regurgitation	0.79089486
70	MP0003635_abnormal_synaptic_transmissio	0.77780812
71	MP0006292_abnormal_olfactory_placode	0.77035954
72	MP0004270_analgesia	0.76188811
73	MP0005501_abnormal_skin_physiology	0.75804420
74	MP0003646_muscle_fatigue	0.75751643
75	MP0005367_renal/urinary_system_phenotyp	0.74733229
76	MP0000516_abnormal_urinary_system	0.74733229
77	MP0006036_abnormal_mitochondrial_physio	0.74283759
78	MP0004742_abnormal_vestibular_system	0.73892677
79	MP0002752_abnormal_somatic_nervous	0.73417134
80	MP0001293_anophthalmia	0.71133149
81	MP0001501_abnormal_sleep_pattern	0.67937587
82	MP0003137_abnormal_impulse_conducting	0.67895511
83	MP0002557_abnormal_social/conspecific_i	0.67689955
84	MP0005377_hearing/vestibular/ear_phenot	0.66440390
85	MP0003878_abnormal_ear_physiology	0.66440390
86	MP0000026_abnormal_inner_ear	0.66149620
87	MP0004859_abnormal_synaptic_plasticity	0.64873821
88	MP0002067_abnormal_sensory_capabilities	0.64852700
89	MP0008875_abnormal_xenobiotic_pharmacok	0.64471929
90	MP0002210_abnormal_sex_determination	0.61825757
91	MP0005595_abnormal_vascular_smooth	0.60452994
92	MP0002177_abnormal_outer_ear	0.59011153
93	MP0001486_abnormal_startle_reflex	0.57884422
94	MP0005385_cardiovascular_system_phenoty	0.57677952
95	MP0001544_abnormal_cardiovascular_syste	0.57677952
96	MP0003942_abnormal_urinary_system	0.56901782
97	MP0001963_abnormal_hearing_physiology	0.56818161
98	MP0000358_abnormal_cell_content/	0.56318828
99	MP0004142_abnormal_muscle_tone	0.55997357
100	MP0003186_abnormal_redox_activity	0.55915684

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	6.68575387
2	Abnormality of DNA repair (HP:0003254)	4.68015753
3	Methylmalonic acidemia (HP:0002912)	4.45727929
4	Ketoacidosis (HP:0001993)	4.41889105
5	Facial hemangioma (HP:0000329)	4.05593479
6	Decreased central vision (HP:0007663)	3.96408069
7	Metaphyseal dysplasia (HP:0100255)	3.94463419
8	Colon cancer (HP:0003003)	3.89476512
9	Methylmalonic aciduria (HP:0012120)	3.82153882
10	Tachypnea (HP:0002789)	3.82034481
11	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.62672795
12	Abnormality of vitamin B metabolism (HP:0004340)	3.59264887
13	Congenital primary aphakia (HP:0007707)	3.52185683
14	Postnatal microcephaly (HP:0005484)	3.49356419
15	Megaloblastic anemia (HP:0001889)	3.49084201
16	Gait imbalance (HP:0002141)	3.45708410
17	Nephrogenic diabetes insipidus (HP:0009806)	3.40992448
18	Medial flaring of the eyebrow (HP:0010747)	3.36489126
19	Abnormal glycosylation (HP:0012345)	3.35997586
20	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.35997586
21	Abnormal protein N-linked glycosylation (HP:0012347)	3.35997586
22	Abnormal protein glycosylation (HP:0012346)	3.35997586
23	Abnormality of serine family amino acid metabolism (HP:0010894)	3.32626443
24	Abnormality of glycine metabolism (HP:0010895)	3.32626443
25	Tubulointerstitial nephritis (HP:0001970)	3.12348658
26	Hypoplastic pelvis (HP:0008839)	3.07870778
27	Ketosis (HP:0001946)	3.03121776
28	Buphthalmos (HP:0000557)	3.02036928
29	Skin nodule (HP:0200036)	3.01646967
30	Reticulocytopenia (HP:0001896)	2.97993990
31	Increased hepatocellular lipid droplets (HP:0006565)	2.95513868
32	Abnormality of serum amino acid levels (HP:0003112)	2.90175794
33	Dry hair (HP:0011359)	2.87998296
34	Testicular atrophy (HP:0000029)	2.71295007
35	Lipid accumulation in hepatocytes (HP:0006561)	2.69290998
36	Mesangial abnormality (HP:0001966)	2.64223034
37	Heterochromia iridis (HP:0001100)	2.63350859
38	Choroideremia (HP:0001139)	2.62559076
39	Nuclear cataract (HP:0100018)	2.61435078
40	Abnormality of vitamin metabolism (HP:0100508)	2.57443237
41	Abnormal number of erythroid precursors (HP:0012131)	2.52952003
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.44823524
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.44823524
44	Macrocytic anemia (HP:0001972)	2.44005448
45	Exercise-induced muscle cramps (HP:0003710)	2.43665342
46	Delayed CNS myelination (HP:0002188)	2.42630481
47	Dicarboxylic aciduria (HP:0003215)	2.39063820
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.39063820
49	Chorioretinal atrophy (HP:0000533)	2.37065089
50	Abnormality of the metopic suture (HP:0005556)	2.36622159
51	Poor coordination (HP:0002370)	2.36324068
52	Conjunctival telangiectasia (HP:0000524)	2.33839372
53	Prominent metopic ridge (HP:0005487)	2.33711586
54	Genital tract atresia (HP:0001827)	2.32002999
55	CNS hypomyelination (HP:0003429)	2.30141708
56	Pendular nystagmus (HP:0012043)	2.29534269
57	Vaginal atresia (HP:0000148)	2.27993321
58	Gout (HP:0001997)	2.27882527
59	Renal dysplasia (HP:0000110)	2.23646673
60	Renal Fanconi syndrome (HP:0001994)	2.20365844
61	Abnormal auditory evoked potentials (HP:0006958)	2.18383846
62	Lower limb asymmetry (HP:0100559)	2.18013903
63	Abnormality of glycolysis (HP:0004366)	2.15122594
64	Decreased testicular size (HP:0008734)	2.12821698
65	Abnormality of cells of the erythroid lineage (HP:0012130)	2.12489416
66	Retinal dysplasia (HP:0007973)	2.11586103
67	Type I transferrin isoform profile (HP:0003642)	2.07475863
68	Abnormality of the anterior horn cell (HP:0006802)	2.05032688
69	Degeneration of anterior horn cells (HP:0002398)	2.05032688
70	Increased CSF lactate (HP:0002490)	2.02626190
71	Adactyly (HP:0009776)	1.97527851
72	Delayed myelination (HP:0012448)	1.97305501
73	Abnormality of methionine metabolism (HP:0010901)	1.97292750
74	Short tibia (HP:0005736)	1.96152799
75	Dyskinesia (HP:0100660)	1.93574213
76	Increased serum pyruvate (HP:0003542)	1.93572335
77	Poor head control (HP:0002421)	1.92464063
78	Reduced antithrombin III activity (HP:0001976)	1.92227786
79	Hemiparesis (HP:0001269)	1.92168517
80	Specific learning disability (HP:0001328)	1.91230784
81	Irregular epiphyses (HP:0010582)	1.91120880
82	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.89039285
83	Hypsarrhythmia (HP:0002521)	1.87761121
84	Abnormality of the labia minora (HP:0012880)	1.87504494
85	Mitochondrial inheritance (HP:0001427)	1.87061427
86	Aplasia/Hypoplasia of the lens (HP:0008063)	1.85758873
87	Broad foot (HP:0001769)	1.83872843
88	Hyperglycinuria (HP:0003108)	1.82259767
89	Abolished electroretinogram (ERG) (HP:0000550)	1.82163498
90	Abnormality of the renal collecting system (HP:0004742)	1.81866304
91	Neuroendocrine neoplasm (HP:0100634)	1.80535098
92	EEG with generalized epileptiform discharges (HP:0011198)	1.80131993
93	IgM deficiency (HP:0002850)	1.79469169
94	Left ventricular hypertrophy (HP:0001712)	1.78805036
95	Abnormality of macular pigmentation (HP:0008002)	1.74366139
96	Generalized aminoaciduria (HP:0002909)	1.73768047
97	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72011160
98	Bony spicule pigmentary retinopathy (HP:0007737)	1.71856647
99	Epileptiform EEG discharges (HP:0011182)	1.69680687
100	Abnormality of homocysteine metabolism (HP:0010919)	1.68469948

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.83224921
2	CASK	3.21486162
3	EPHB2	3.06463746
4	TAF1	2.77388110
5	WNK3	2.66625959
6	MAP3K6	2.60374160
7	CDK19	2.36977545
8	MAP2K7	2.33189743
9	STK24	2.28095088
10	MAP3K4	2.25421858
11	TAOK3	2.19257624
12	MAPKAPK5	1.97369009
13	DYRK2	1.97338416
14	ZAK	1.90231034
15	ADRBK2	1.86346385
16	AKT3	1.84690077
17	MAP2K4	1.82329518
18	EPHA3	1.78384795
19	PAK3	1.53810666
20	MAP3K12	1.53278931
21	ACVR1B	1.49185686
22	FRK	1.48801693
23	CDK9	1.48039825
24	VRK1	1.43175623
25	FLT3	1.40614263
26	CSNK1G2	1.39163858
27	MAP4K2	1.36185587
28	GRK1	1.35697529
29	ERBB3	1.34079929
30	EPHA4	1.31506005
31	BCKDK	1.30545859
32	CSNK1G3	1.26815207
33	CDK8	1.24301063
34	TGFBR1	1.23555412
35	CSNK1A1L	1.19106641
36	STK3	1.18529448
37	BMPR2	1.18419726
38	FER	1.17973703
39	SCYL2	1.09572175
40	TRIM28	1.09097488
41	STK4	1.07922875
42	CSNK1G1	1.05564534
43	TSSK6	1.04771925
44	OBSCN	1.03330866
45	MARK1	1.02615043
46	STK38L	1.01690786
47	PASK	1.00139628
48	MET	0.99777272
49	MST4	0.97732851
50	MAP3K11	0.92582043
51	BMPR1B	0.88272575
52	NEK1	0.87589315
53	MAPK13	0.86279791
54	PLK2	0.85572088
55	PLK3	0.82061588
56	MKNK1	0.79372003
57	PBK	0.77743315
58	RPS6KB2	0.73112624
59	FES	0.70016804
60	NTRK3	0.65376285
61	AURKA	0.63312018
62	SRPK1	0.63134393
63	PRKD3	0.62630640
64	MINK1	0.60552584
65	PINK1	0.57963172
66	CAMK2A	0.57888829
67	BCR	0.57229006
68	PHKG1	0.56673129
69	PHKG2	0.56673129
70	ATR	0.55075745
71	INSRR	0.54781876
72	GRK5	0.54433288
73	TRPM7	0.53378014
74	PRKCE	0.53333320
75	ADRBK1	0.52498434
76	CAMK1	0.50273036
77	CSNK1E	0.50252929
78	MAP2K6	0.49850647
79	MAPKAPK3	0.48690602
80	MYLK	0.48689111
81	PLK4	0.46035941
82	ALK	0.45907183
83	CAMK2D	0.45662717
84	PAK6	0.44805872
85	PRKACG	0.41018122
86	CSNK1A1	0.38525895
87	MAP3K5	0.38387178
88	CSNK2A2	0.37403225
89	PRKACA	0.37376921
90	PRKACB	0.35186590
91	TIE1	0.34234335
92	DYRK1A	0.33611024
93	ROCK2	0.33158294
94	EPHB1	0.32181438
95	ATM	0.31303608
96	NTRK1	0.30466915
97	MAPK15	0.27144970
98	LIMK1	0.26853871
99	GRK6	0.26684261
100	FGFR2	0.26299756

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	9.45886643
2	Butanoate metabolism_Homo sapiens_hsa00650	3.57752072
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.84919841
4	Nucleotide excision repair_Homo sapiens_hsa03420	2.48626305
5	Mismatch repair_Homo sapiens_hsa03430	2.44939234
6	Propanoate metabolism_Homo sapiens_hsa00640	2.24110049
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16730772
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.15023994
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.09315455
10	Protein export_Homo sapiens_hsa03060	1.96042195
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78089527
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69309527
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.68821831
14	DNA replication_Homo sapiens_hsa03030	1.63697740
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.63688885
16	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.59124217
17	Ribosome_Homo sapiens_hsa03010	1.57044741
18	Proteasome_Homo sapiens_hsa03050	1.46556902
19	Huntingtons disease_Homo sapiens_hsa05016	1.31217478
20	Parkinsons disease_Homo sapiens_hsa05012	1.31079180
21	RNA transport_Homo sapiens_hsa03013	1.15275831
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.10945176
23	RNA polymerase_Homo sapiens_hsa03020	1.07950908
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.06482014
25	One carbon pool by folate_Homo sapiens_hsa00670	1.05346852
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04850784
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.04674813
28	Pentose phosphate pathway_Homo sapiens_hsa00030	1.03079029
29	Long-term depression_Homo sapiens_hsa04730	1.01484743
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00349735
31	Alzheimers disease_Homo sapiens_hsa05010	0.97711915
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.96150530
33	Glutathione metabolism_Homo sapiens_hsa00480	0.93533004
34	Taste transduction_Homo sapiens_hsa04742	0.88499120
35	Carbon metabolism_Homo sapiens_hsa01200	0.86990501
36	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84688833
37	Fatty acid metabolism_Homo sapiens_hsa01212	0.80604268
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80568219
39	RNA degradation_Homo sapiens_hsa03018	0.79826347
40	Homologous recombination_Homo sapiens_hsa03440	0.79443603
41	Nicotine addiction_Homo sapiens_hsa05033	0.79285404
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.77684319
43	Purine metabolism_Homo sapiens_hsa00230	0.76217228
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73385819
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70140907
46	Phototransduction_Homo sapiens_hsa04744	0.68508310
47	Metabolic pathways_Homo sapiens_hsa01100	0.66441102
48	Folate biosynthesis_Homo sapiens_hsa00790	0.65429176
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65285542
50	Pancreatic secretion_Homo sapiens_hsa04972	0.64935477
51	Fatty acid elongation_Homo sapiens_hsa00062	0.63264263
52	Spliceosome_Homo sapiens_hsa03040	0.62679102
53	Regulation of autophagy_Homo sapiens_hsa04140	0.62035911
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61774211
55	Peroxisome_Homo sapiens_hsa04146	0.59701893
56	Salivary secretion_Homo sapiens_hsa04970	0.59533009
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58870831
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.58514529
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.58339030
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55086452
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54804272
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53635094
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52796250
64	Circadian entrainment_Homo sapiens_hsa04713	0.52543535
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51617677
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51583290
67	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.49830926
68	Basal transcription factors_Homo sapiens_hsa03022	0.48272230
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.46493760
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44724285
71	Galactose metabolism_Homo sapiens_hsa00052	0.44423177
72	Caffeine metabolism_Homo sapiens_hsa00232	0.44321204
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.43963409
74	Serotonergic synapse_Homo sapiens_hsa04726	0.43651034
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42936702
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42583146
77	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.42247980
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42042859
79	Insulin secretion_Homo sapiens_hsa04911	0.41509599
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41354952
81	Cholinergic synapse_Homo sapiens_hsa04725	0.41159036
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41155516
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41118781
84	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39222087
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39047524
86	Gastric acid secretion_Homo sapiens_hsa04971	0.38800622
87	Long-term potentiation_Homo sapiens_hsa04720	0.37168816
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36671682
89	Fatty acid degradation_Homo sapiens_hsa00071	0.35175902
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33693832
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.33120210
92	Base excision repair_Homo sapiens_hsa03410	0.32173611
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31525625
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30345120
95	African trypanosomiasis_Homo sapiens_hsa05143	0.29320931
96	p53 signaling pathway_Homo sapiens_hsa04115	0.28597974
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28444395
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26354752
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.26111865
100	Retinol metabolism_Homo sapiens_hsa00830	0.25552937

ALG1L12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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