ALG1L15P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.91830343
2regulation of DNA methylation (GO:0044030)8.97449880
3regulation of acrosome reaction (GO:0060046)8.48231892
4piRNA metabolic process (GO:0034587)7.99840344
5multicellular organism reproduction (GO:0032504)7.34098355
6meiotic cell cycle (GO:0051321)7.28653519
7regulation of meiosis I (GO:0060631)7.04293004
8DNA methylation involved in gamete generation (GO:0043046)6.61109092
9positive regulation of histone H3-K4 methylation (GO:0051571)6.54215497
10oocyte development (GO:0048599)6.29490894
11retinal cone cell development (GO:0046549)5.98243819
12regulation of histone H3-K9 methylation (GO:0051570)5.89545923
13regulation of steroid hormone secretion (GO:2000831)5.82047682
14female gamete generation (GO:0007292)5.82020480
15negative regulation of reproductive process (GO:2000242)5.77937414
16glycine transport (GO:0015816)5.64389053
17protein kinase C signaling (GO:0070528)5.63808382
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.43122314
19positive regulation of mitotic sister chromatid separation (GO:1901970)5.43122314
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.43122314
21positive regulation of humoral immune response (GO:0002922)5.23241368
22gene silencing by RNA (GO:0031047)5.14291241
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.00252960
24reproduction (GO:0000003)4.95321034
25negative regulation of cAMP-mediated signaling (GO:0043951)4.87917632
26mitotic metaphase plate congression (GO:0007080)4.78675029
27regulation of cell maturation (GO:1903429)4.74033867
28synapsis (GO:0007129)4.73886061
29positive regulation of uterine smooth muscle contraction (GO:0070474)4.57150951
30protein localization to kinetochore (GO:0034501)4.54351810
31positive regulation of chromosome segregation (GO:0051984)4.43801666
32protein localization to chromosome, centromeric region (GO:0071459)4.41407734
33male meiosis (GO:0007140)4.30495783
34establishment of chromosome localization (GO:0051303)4.27820931
35centriole replication (GO:0007099)4.22539186
36positive regulation of gastrulation (GO:2000543)4.20943159
37binding of sperm to zona pellucida (GO:0007339)4.15977252
38CENP-A containing nucleosome assembly (GO:0034080)4.01668655
39metaphase plate congression (GO:0051310)4.01123117
40negative regulation of histone methylation (GO:0031061)3.93493247
41fertilization (GO:0009566)3.89935206
42protein localization to chromosome (GO:0034502)3.81361146
43single fertilization (GO:0007338)3.75333549
44attachment of spindle microtubules to kinetochore (GO:0008608)3.72759184
45DNA methylation (GO:0006306)3.71889695
46DNA alkylation (GO:0006305)3.71889695
47citrulline biosynthetic process (GO:0019240)3.64948309
48mitotic chromosome condensation (GO:0007076)3.62761138
49histone H2A acetylation (GO:0043968)3.62592988
50chromatin remodeling at centromere (GO:0031055)3.61592900
51sperm-egg recognition (GO:0035036)3.61574577
52regulation of histone H3-K4 methylation (GO:0051569)3.61307963
53male meiosis I (GO:0007141)3.60958415
54regulation of uterine smooth muscle contraction (GO:0070472)3.58581419
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.56773677
56regulation of meiosis (GO:0040020)3.53192077
57gene silencing (GO:0016458)3.48880713
58negative regulation of execution phase of apoptosis (GO:1900118)3.46216319
59positive regulation of reproductive process (GO:2000243)3.44969590
60chromosome organization involved in meiosis (GO:0070192)3.44422371
61positive regulation of histone methylation (GO:0031062)3.41615429
62gonadal mesoderm development (GO:0007506)3.41272398
63primitive streak formation (GO:0090009)3.40988545
64regulation of spindle organization (GO:0090224)3.39783333
65positive regulation of steroid hormone secretion (GO:2000833)3.39753791
66meiotic nuclear division (GO:0007126)3.36588640
67histone exchange (GO:0043486)3.30208996
68hyperosmotic salinity response (GO:0042538)3.29000161
69spermatid nucleus differentiation (GO:0007289)3.26337897
70relaxation of smooth muscle (GO:0044557)3.22714789
71regulation of reproductive process (GO:2000241)3.21677958
72synaptonemal complex assembly (GO:0007130)3.20802884
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.20772162
74regulation of hypersensitivity (GO:0002883)3.18613033
75regulation of corticosteroid hormone secretion (GO:2000846)3.18499578
76meiotic cell cycle process (GO:1903046)3.12633195
77regulation of spindle checkpoint (GO:0090231)3.11996749
78meiosis I (GO:0007127)3.06810744
79neuron fate determination (GO:0048664)3.04794668
80oogenesis (GO:0048477)3.01648678
81regulation of calcium ion-dependent exocytosis (GO:0017158)3.01182207
82synaptonemal complex organization (GO:0070193)2.99242099
83DNA methylation or demethylation (GO:0044728)2.96572616
84regulation of meiotic cell cycle (GO:0051445)2.95749279
85cell-cell recognition (GO:0009988)2.92496507
86urate metabolic process (GO:0046415)2.90711604
87mismatch repair (GO:0006298)2.88950962
88DNA modification (GO:0006304)2.87596510
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84130262
90regulation of mitotic spindle checkpoint (GO:1903504)2.84130262
91DNA replication checkpoint (GO:0000076)2.80927840
92pyrimidine-containing compound transmembrane transport (GO:0072531)2.79559759
93negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.79218055
94base-excision repair, AP site formation (GO:0006285)2.78597629
95L-amino acid import (GO:0043092)2.78010623
96centriole assembly (GO:0098534)2.77763779
97DNA replication-independent nucleosome organization (GO:0034724)2.77749096
98DNA replication-independent nucleosome assembly (GO:0006336)2.77749096
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77378667
100DNA replication-dependent nucleosome assembly (GO:0006335)2.77204765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.88088115
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18448790
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24003302
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54383538
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43779834
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.33249214
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31419239
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21784566
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21072802
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.05395446
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02899742
12EZH2_22144423_ChIP-Seq_EOC_Human13.8647916
13GBX2_23144817_ChIP-Seq_PC3_Human1.92240650
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87994415
15E2F7_22180533_ChIP-Seq_HELA_Human1.85083878
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84260301
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73358345
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69846119
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69846119
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69846119
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59856286
22VDR_22108803_ChIP-Seq_LS180_Human1.58464072
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55478106
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51843273
25HTT_18923047_ChIP-ChIP_STHdh_Human1.49208280
26IRF1_19129219_ChIP-ChIP_H3396_Human1.46850956
27ZNF274_21170338_ChIP-Seq_K562_Hela1.43768720
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42649012
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41414261
30PRDM14_20953172_ChIP-Seq_ESCs_Human1.38423366
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.36216566
32GATA1_22025678_ChIP-Seq_K562_Human1.35125723
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30263484
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.30056132
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27649580
36CBP_20019798_ChIP-Seq_JUKART_Human1.26485401
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26485401
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.25122053
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.23870360
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23673244
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22593709
42MYC_18940864_ChIP-ChIP_HL60_Human1.21735871
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18960922
44VDR_23849224_ChIP-Seq_CD4+_Human1.17520721
45EWS_26573619_Chip-Seq_HEK293_Human1.15482527
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.14206079
47NANOG_20526341_ChIP-Seq_ESCs_Human1.13543010
48FOXP3_21729870_ChIP-Seq_TREG_Human1.12669671
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11373053
50FUS_26573619_Chip-Seq_HEK293_Human1.10797167
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08376136
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08376136
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.08102092
54AR_25329375_ChIP-Seq_VCAP_Human1.07932398
55TCF4_23295773_ChIP-Seq_U87_Human1.03059165
56NCOR_22424771_ChIP-Seq_293T_Human1.02998235
57AR_20517297_ChIP-Seq_VCAP_Human1.00010705
58FOXH1_21741376_ChIP-Seq_EPCs_Human0.99211035
59ER_23166858_ChIP-Seq_MCF-7_Human0.99057439
60FOXA1_25329375_ChIP-Seq_VCAP_Human0.97814393
61FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97814393
62CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97715741
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94597152
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94170913
65RUNX2_22187159_ChIP-Seq_PCA_Human0.93967650
66YY1_21170310_ChIP-Seq_MESCs_Mouse0.93785136
67P300_19829295_ChIP-Seq_ESCs_Human0.93395791
68TP53_22573176_ChIP-Seq_HFKS_Human0.92729172
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91239920
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90011027
71CBP_21632823_ChIP-Seq_H3396_Human0.89732497
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89414662
73SMAD4_21799915_ChIP-Seq_A2780_Human0.87838111
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87820614
75STAT3_23295773_ChIP-Seq_U87_Human0.87513512
76CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86798341
77RUNX_20019798_ChIP-Seq_JUKART_Human0.86043984
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85948818
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.85773803
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.84564692
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84452558
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83858641
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83180451
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82983940
85SMRT_27268052_Chip-Seq_Bcells_Human0.82756874
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82530767
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82004551
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79165570
89TCF4_22108803_ChIP-Seq_LS180_Human0.79132439
90FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78339350
91TAF15_26573619_Chip-Seq_HEK293_Human0.77592917
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77409029
93MYC_19829295_ChIP-Seq_ESCs_Human0.76742941
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.76532493
95AR_21909140_ChIP-Seq_LNCAP_Human0.76121431
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76021380
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.75387244
98NANOG_19829295_ChIP-Seq_ESCs_Human0.74892669
99SOX2_19829295_ChIP-Seq_ESCs_Human0.74892669
100ERG_20517297_ChIP-Seq_VCAP_Human0.74670902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.42315957
2MP0008877_abnormal_DNA_methylation5.27464510
3MP0006292_abnormal_olfactory_placode4.22907360
4MP0008789_abnormal_olfactory_epithelium3.54937508
5MP0002138_abnormal_hepatobiliary_system3.21076277
6MP0005377_hearing/vestibular/ear_phenot3.02255054
7MP0003878_abnormal_ear_physiology3.02255054
8MP0005395_other_phenotype3.00393957
9MP0005499_abnormal_olfactory_system2.98868130
10MP0005394_taste/olfaction_phenotype2.98868130
11MP0003890_abnormal_embryonic-extraembry2.80527345
12MP0002139_abnormal_hepatobiliary_system2.76464277
13MP0002234_abnormal_pharynx_morphology2.60413798
14MP0005360_urolithiasis2.56532814
15MP0003693_abnormal_embryo_hatching2.47274360
16MP0001929_abnormal_gametogenesis2.26955793
17MP0003699_abnormal_female_reproductive2.25671285
18MP0005410_abnormal_fertilization2.24667060
19MP0003879_abnormal_hair_cell2.14444498
20MP0002210_abnormal_sex_determination1.98523091
21MP0002160_abnormal_reproductive_system1.90125417
22MP0010094_abnormal_chromosome_stability1.90039828
23MP0003077_abnormal_cell_cycle1.82239922
24MP0008057_abnormal_DNA_replication1.72815745
25MP0003183_abnormal_peptide_metabolism1.72364325
26MP0010030_abnormal_orbit_morphology1.70273804
27MP0000653_abnormal_sex_gland1.67197807
28MP0001293_anophthalmia1.64719533
29MP0003111_abnormal_nucleus_morphology1.61363430
30MP0005389_reproductive_system_phenotype1.55173347
31MP0002161_abnormal_fertility/fecundity1.54929321
32MP0008058_abnormal_DNA_repair1.52371688
33MP0001119_abnormal_female_reproductive1.50328725
34MP0003252_abnormal_bile_duct1.42828842
35MP0005551_abnormal_eye_electrophysiolog1.37925980
36MP0010307_abnormal_tumor_latency1.36050698
37MP0003136_yellow_coat_color1.32936269
38MP0000631_abnormal_neuroendocrine_gland1.30714278
39MP0001145_abnormal_male_reproductive1.28328598
40MP0009379_abnormal_foot_pigmentation1.28259019
41MP0003698_abnormal_male_reproductive1.23085424
42MP0008932_abnormal_embryonic_tissue1.22334863
43MP0005075_abnormal_melanosome_morpholog1.20745412
44MP0000427_abnormal_hair_cycle1.12965817
45MP0002272_abnormal_nervous_system1.12560112
46MP0005646_abnormal_pituitary_gland1.09696184
47MP0003195_calcinosis1.06321805
48MP0000566_synostosis1.04795244
49MP0006276_abnormal_autonomic_nervous1.01788290
50MP0001730_embryonic_growth_arrest1.01753226
51MP0004142_abnormal_muscle_tone0.99948123
52MP0003786_premature_aging0.99552571
53MP0006072_abnormal_retinal_apoptosis0.98524882
54MP0005647_abnormal_sex_gland0.94477981
55MP0001919_abnormal_reproductive_system0.94319584
56MP0001986_abnormal_taste_sensitivity0.94118746
57MP0003119_abnormal_digestive_system0.93865429
58MP0001984_abnormal_olfaction0.89740549
59MP0001963_abnormal_hearing_physiology0.87994158
60MP0000678_abnormal_parathyroid_gland0.87287199
61MP0010234_abnormal_vibrissa_follicle0.86950935
62MP0004957_abnormal_blastocyst_morpholog0.85912042
63MP0000569_abnormal_digit_pigmentation0.85291225
64MP0002928_abnormal_bile_duct0.84092747
65MP0000762_abnormal_tongue_morphology0.82423570
66MP0001486_abnormal_startle_reflex0.78919547
67MP0008995_early_reproductive_senescence0.78076665
68MP0005319_abnormal_enzyme/_coenzyme0.76231778
69MP0001324_abnormal_eye_pigmentation0.75708990
70MP0001664_abnormal_digestion0.75185889
71MP0002735_abnormal_chemical_nociception0.74160114
72MP0000015_abnormal_ear_pigmentation0.73654097
73MP0003950_abnormal_plasma_membrane0.73353274
74MP0001485_abnormal_pinna_reflex0.71774192
75MP0003121_genomic_imprinting0.71117924
76MP0004215_abnormal_myocardial_fiber0.70902791
77MP0005380_embryogenesis_phenotype0.69797959
78MP0001672_abnormal_embryogenesis/_devel0.69797959
79MP0005085_abnormal_gallbladder_physiolo0.68446289
80MP0005174_abnormal_tail_pigmentation0.65255897
81MP0004145_abnormal_muscle_electrophysio0.65132472
82MP0005671_abnormal_response_to0.62347984
83MP0002233_abnormal_nose_morphology0.61379938
84MP0002090_abnormal_vision0.61076154
85MP0002638_abnormal_pupillary_reflex0.60616966
86MP0002102_abnormal_ear_morphology0.60326657
87MP0009333_abnormal_splenocyte_physiolog0.59824855
88MP0010368_abnormal_lymphatic_system0.59724748
89MP0009840_abnormal_foam_cell0.59305774
90MP0000026_abnormal_inner_ear0.59047257
91MP0003567_abnormal_fetal_cardiomyocyte0.56496970
92MP0000049_abnormal_middle_ear0.55834124
93MP0004019_abnormal_vitamin_homeostasis0.54101153
94MP0003959_abnormal_lean_body0.53774729
95MP0010678_abnormal_skin_adnexa0.53550111
96MP0001765_abnormal_ion_homeostasis0.49376425
97MP0001666_abnormal_nutrient_absorption0.48836177
98MP0005503_abnormal_tendon_morphology0.48466471
99MP0002751_abnormal_autonomic_nervous0.47981457
100MP0002229_neurodegeneration0.47857878

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.02906620
2Generalized aminoaciduria (HP:0002909)5.05117629
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.23066494
4Abnormality of abdominal situs (HP:0011620)4.06744140
5Abdominal situs inversus (HP:0003363)4.06744140
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.01155546
7Hypoplasia of the fovea (HP:0007750)4.01155546
8Absent septum pellucidum (HP:0001331)3.85643837
9Septo-optic dysplasia (HP:0100842)3.82175255
10Impulsivity (HP:0100710)3.75150393
11Hypophosphatemic rickets (HP:0004912)3.72388117
12Male infertility (HP:0003251)3.63141511
13Lip pit (HP:0100267)3.44153092
14Abnormality of the fovea (HP:0000493)3.42811408
15Gonadotropin excess (HP:0000837)3.41854455
16Infertility (HP:0000789)3.33831837
17Median cleft lip (HP:0000161)3.31681128
18Anterior segment dysgenesis (HP:0007700)3.27240487
19Premature ovarian failure (HP:0008209)3.26178665
20Oligodactyly (hands) (HP:0001180)3.23732497
21Abnormal gallbladder physiology (HP:0012438)3.19484889
22Cholecystitis (HP:0001082)3.19484889
23Short tibia (HP:0005736)3.17136463
24Azoospermia (HP:0000027)3.15681922
25Facial hemangioma (HP:0000329)3.13758691
26Abnormality of the septum pellucidum (HP:0007375)3.11273935
27Proximal tubulopathy (HP:0000114)3.08129069
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07003144
29Osteomalacia (HP:0002749)3.02292071
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.97952507
31Abnormality of the labia minora (HP:0012880)2.95100114
32Abnormal ciliary motility (HP:0012262)2.93414445
33Chromsome breakage (HP:0040012)2.93034665
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.86800055
35Pancreatic cysts (HP:0001737)2.80389522
36Myokymia (HP:0002411)2.74690710
37Bile duct proliferation (HP:0001408)2.73001364
38Abnormal biliary tract physiology (HP:0012439)2.73001364
39Aplastic anemia (HP:0001915)2.72901799
40Fair hair (HP:0002286)2.69101570
41Severe visual impairment (HP:0001141)2.68378591
42Pancreatic fibrosis (HP:0100732)2.64760873
43Abnormal respiratory motile cilium physiology (HP:0012261)2.60749108
44Abnormal spermatogenesis (HP:0008669)2.59520279
45Hypokinesia (HP:0002375)2.59441900
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.58654385
47Absent/shortened dynein arms (HP:0200106)2.58654385
48Pendular nystagmus (HP:0012043)2.54540724
49Molar tooth sign on MRI (HP:0002419)2.46041459
50Abnormality of midbrain morphology (HP:0002418)2.46041459
51Decreased central vision (HP:0007663)2.41935912
52Aplasia/Hypoplasia of the macula (HP:0008059)2.39471573
53Attenuation of retinal blood vessels (HP:0007843)2.36622940
54Papillary thyroid carcinoma (HP:0002895)2.32121914
55True hermaphroditism (HP:0010459)2.28694167
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24972451
57Oligodactyly (HP:0012165)2.23315275
58Cone-rod dystrophy (HP:0000548)2.22461261
59Aplasia of the musculature (HP:0100854)2.21031936
60Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19424161
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.18782977
62Optic nerve hypoplasia (HP:0000609)2.17442634
63Rhinitis (HP:0012384)2.17142923
64Urethral obstruction (HP:0000796)2.13518368
65Dysdiadochokinesis (HP:0002075)2.12126167
66Renal cortical cysts (HP:0000803)2.11406846
67Stillbirth (HP:0003826)2.10674741
68Capillary hemangiomas (HP:0005306)2.04553065
69Pulmonary fibrosis (HP:0002206)2.03414036
70Cystic liver disease (HP:0006706)2.02809504
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01666114
72Abnormality of the anterior horn cell (HP:0006802)2.01664230
73Degeneration of anterior horn cells (HP:0002398)2.01664230
74Secondary amenorrhea (HP:0000869)2.00082349
75Anencephaly (HP:0002323)1.99661809
76Enlarged penis (HP:0000040)1.99509222
77Posterior subcapsular cataract (HP:0007787)1.99099459
78Wrist flexion contracture (HP:0001239)1.99028959
79Abnormal lung lobation (HP:0002101)1.98351444
80Malnutrition (HP:0004395)1.97450778
81Metaphyseal irregularity (HP:0003025)1.97251073
82Congenital sensorineural hearing impairment (HP:0008527)1.95627250
83Rickets (HP:0002748)1.94357675
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93084889
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92102774
86Generalized hypopigmentation of hair (HP:0011358)1.90876161
87Decreased circulating renin level (HP:0003351)1.90644598
88Abnormality of urine glucose concentration (HP:0011016)1.89949640
89Glycosuria (HP:0003076)1.89949640
90Spinal muscular atrophy (HP:0007269)1.89628026
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.88300879
92Skin pits (HP:0100276)1.85202056
93Maternal diabetes (HP:0009800)1.85040992
94Birth length less than 3rd percentile (HP:0003561)1.83760888
95Small intestinal stenosis (HP:0012848)1.82407258
96Duodenal stenosis (HP:0100867)1.82407258
97Meckel diverticulum (HP:0002245)1.81068960
98Preaxial hand polydactyly (HP:0001177)1.77786112
99Colon cancer (HP:0003003)1.74340849
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72447192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.19904749
2TAOK34.03346293
3MAP3K133.86417892
4ARAF3.73820986
5BUB13.34554528
6TXK3.19137072
7TTK3.02164074
8AURKA2.63431563
9NEK62.61677449
10CDK192.54008342
11ZAK2.40051428
12STK242.20747563
13NTRK22.08001804
14CDK92.00018838
15MOS1.93290415
16KDR1.85001315
17TLK11.80510727
18MET1.77461519
19MUSK1.74410626
20BRAF1.68686050
21VRK11.66563795
22TESK21.64467516
23CDC71.62169960
24TRIM281.49714432
25PLK11.43383511
26TYRO31.34856220
27MST41.34698825
28TNK21.31325180
29PRKCI1.29887632
30NEK91.24493797
31KSR21.20494526
32CDK121.18158647
33MAPKAPK31.14199856
34TGFBR11.09662706
35PIM11.08252212
36TNIK1.07426570
37CDK71.04842410
38MELK1.04267895
39BCKDK1.02637757
40PLK31.01537479
41PIK3CG0.99609818
42RAF10.99475339
43TIE10.86596209
44NEK20.85567028
45BRSK20.85386802
46BMPR1B0.84375384
47NUAK10.79956805
48STK30.79500756
49EIF2AK30.79268499
50CHEK10.76966546
51AURKB0.75705508
52MAP3K80.75548592
53KSR10.73715460
54BRSK10.72944398
55MAP3K50.71794028
56ADRBK20.71149557
57RPS6KA40.70483033
58PAK10.67796131
59NME10.64653624
60ATR0.63921659
61WNK30.60902861
62CAMK1D0.58751739
63MAP3K40.58617910
64CSNK1G10.55690721
65PLK40.54344594
66NTRK30.53877942
67CDK20.53119092
68CSNK1G30.52979015
69CHEK20.51429513
70MARK30.50705235
71WNK10.50256391
72PKN10.50028744
73VRK20.47486158
74GRK10.44784723
75CAMK2A0.43686947
76ITK0.43652998
77ATM0.42906645
78CDK10.40549905
79PRKACA0.39873703
80STK390.39169746
81CSNK1D0.38793043
82PRKG10.36391978
83TESK10.33034257
84OXSR10.32509886
85CDK80.32225607
86TRPM70.31443514
87CSNK1E0.30953596
88MAP3K120.30470784
89MAPK130.29416797
90WEE10.28605725
91LCK0.27152902
92PRKCZ0.27042244
93ACVR1B0.26892902
94NEK10.26793055
95TGFBR20.26576083
96GRK60.26303546
97PRKACB0.25132142
98STK100.24801124
99CSNK1A1L0.24020777
100JAK30.23129309

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.24548861
2Cell cycle_Homo sapiens_hsa041103.71448305
3Mismatch repair_Homo sapiens_hsa034303.17783560
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.16917155
5Homologous recombination_Homo sapiens_hsa034403.00776760
6Caffeine metabolism_Homo sapiens_hsa002323.00339482
7Oocyte meiosis_Homo sapiens_hsa041142.85723594
8Ovarian steroidogenesis_Homo sapiens_hsa049132.82450706
9Phototransduction_Homo sapiens_hsa047442.70571114
10Fanconi anemia pathway_Homo sapiens_hsa034602.64117008
11RNA degradation_Homo sapiens_hsa030182.49728457
12Base excision repair_Homo sapiens_hsa034102.46610661
13DNA replication_Homo sapiens_hsa030302.29631093
14RNA polymerase_Homo sapiens_hsa030202.16876050
15RNA transport_Homo sapiens_hsa030132.10536676
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08495684
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.03123282
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.92272899
19Olfactory transduction_Homo sapiens_hsa047401.91565924
20Nucleotide excision repair_Homo sapiens_hsa034201.91522157
21Proteasome_Homo sapiens_hsa030501.90365518
22Dorso-ventral axis formation_Homo sapiens_hsa043201.86445162
23p53 signaling pathway_Homo sapiens_hsa041151.52822672
24Circadian rhythm_Homo sapiens_hsa047101.47779323
25Nicotine addiction_Homo sapiens_hsa050331.43757910
26Taste transduction_Homo sapiens_hsa047421.35699681
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31369060
28Vitamin digestion and absorption_Homo sapiens_hsa049771.25745027
29ABC transporters_Homo sapiens_hsa020101.19977778
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19856753
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19291928
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10495039
33Autoimmune thyroid disease_Homo sapiens_hsa053201.08942052
34Renin-angiotensin system_Homo sapiens_hsa046141.08777611
35Ribosome_Homo sapiens_hsa030101.04976446
36Primary immunodeficiency_Homo sapiens_hsa053401.04394841
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03268450
38Fatty acid elongation_Homo sapiens_hsa000620.97477614
39Huntingtons disease_Homo sapiens_hsa050160.97175361
40One carbon pool by folate_Homo sapiens_hsa006700.96084147
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94774428
42Purine metabolism_Homo sapiens_hsa002300.92942956
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92666034
44Parkinsons disease_Homo sapiens_hsa050120.86544529
45Folate biosynthesis_Homo sapiens_hsa007900.86378381
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83529973
47Graft-versus-host disease_Homo sapiens_hsa053320.83074128
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82804368
49Oxidative phosphorylation_Homo sapiens_hsa001900.79898770
50Cardiac muscle contraction_Homo sapiens_hsa042600.79284091
51Morphine addiction_Homo sapiens_hsa050320.78482437
52Protein export_Homo sapiens_hsa030600.75849566
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75592634
54Linoleic acid metabolism_Homo sapiens_hsa005910.74666857
55Allograft rejection_Homo sapiens_hsa053300.71461022
56T cell receptor signaling pathway_Homo sapiens_hsa046600.69287475
57Gap junction_Homo sapiens_hsa045400.67410498
58Spliceosome_Homo sapiens_hsa030400.63082264
59GABAergic synapse_Homo sapiens_hsa047270.62793737
60Propanoate metabolism_Homo sapiens_hsa006400.58025518
61Butanoate metabolism_Homo sapiens_hsa006500.57796859
62Retinol metabolism_Homo sapiens_hsa008300.56146838
63mRNA surveillance pathway_Homo sapiens_hsa030150.55371684
64Pyrimidine metabolism_Homo sapiens_hsa002400.55354965
65Antigen processing and presentation_Homo sapiens_hsa046120.54285225
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53236545
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50715241
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46815356
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.45279013
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.43974661
71Inositol phosphate metabolism_Homo sapiens_hsa005620.40980361
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.39215845
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38990740
74Hematopoietic cell lineage_Homo sapiens_hsa046400.36268946
75HTLV-I infection_Homo sapiens_hsa051660.35626611
76Herpes simplex infection_Homo sapiens_hsa051680.34393237
77Chemical carcinogenesis_Homo sapiens_hsa052040.34387577
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31742656
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31216356
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30357559
81TGF-beta signaling pathway_Homo sapiens_hsa043500.30165505
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.29732400
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29723117
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.28785680
85Serotonergic synapse_Homo sapiens_hsa047260.27643720
86Rheumatoid arthritis_Homo sapiens_hsa053230.27586683
87Type I diabetes mellitus_Homo sapiens_hsa049400.26686017
88Alzheimers disease_Homo sapiens_hsa050100.24014553
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23552877
90Bile secretion_Homo sapiens_hsa049760.21273062
91Metabolic pathways_Homo sapiens_hsa011000.21142909
92Sulfur metabolism_Homo sapiens_hsa009200.20474153
93Sulfur relay system_Homo sapiens_hsa041220.19970747
94Selenocompound metabolism_Homo sapiens_hsa004500.19723082
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16801962
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16135224
97Arachidonic acid metabolism_Homo sapiens_hsa005900.13854625
98Thyroid cancer_Homo sapiens_hsa052160.13632511
99Peroxisome_Homo sapiens_hsa041460.12598424
100Nitrogen metabolism_Homo sapiens_hsa009100.12143171

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »