Rank | Gene Set | Z-score |
---|---|---|
1 | regulation of female gonad development (GO:2000194) | 9.91830343 |
2 | regulation of DNA methylation (GO:0044030) | 8.97449880 |
3 | regulation of acrosome reaction (GO:0060046) | 8.48231892 |
4 | piRNA metabolic process (GO:0034587) | 7.99840344 |
5 | multicellular organism reproduction (GO:0032504) | 7.34098355 |
6 | meiotic cell cycle (GO:0051321) | 7.28653519 |
7 | regulation of meiosis I (GO:0060631) | 7.04293004 |
8 | DNA methylation involved in gamete generation (GO:0043046) | 6.61109092 |
9 | positive regulation of histone H3-K4 methylation (GO:0051571) | 6.54215497 |
10 | oocyte development (GO:0048599) | 6.29490894 |
11 | retinal cone cell development (GO:0046549) | 5.98243819 |
12 | regulation of histone H3-K9 methylation (GO:0051570) | 5.89545923 |
13 | regulation of steroid hormone secretion (GO:2000831) | 5.82047682 |
14 | female gamete generation (GO:0007292) | 5.82020480 |
15 | negative regulation of reproductive process (GO:2000242) | 5.77937414 |
16 | glycine transport (GO:0015816) | 5.64389053 |
17 | protein kinase C signaling (GO:0070528) | 5.63808382 |
18 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 5.43122314 |
19 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 5.43122314 |
20 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 5.43122314 |
21 | positive regulation of humoral immune response (GO:0002922) | 5.23241368 |
22 | gene silencing by RNA (GO:0031047) | 5.14291241 |
23 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.00252960 |
24 | reproduction (GO:0000003) | 4.95321034 |
25 | negative regulation of cAMP-mediated signaling (GO:0043951) | 4.87917632 |
26 | mitotic metaphase plate congression (GO:0007080) | 4.78675029 |
27 | regulation of cell maturation (GO:1903429) | 4.74033867 |
28 | synapsis (GO:0007129) | 4.73886061 |
29 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 4.57150951 |
30 | protein localization to kinetochore (GO:0034501) | 4.54351810 |
31 | positive regulation of chromosome segregation (GO:0051984) | 4.43801666 |
32 | protein localization to chromosome, centromeric region (GO:0071459) | 4.41407734 |
33 | male meiosis (GO:0007140) | 4.30495783 |
34 | establishment of chromosome localization (GO:0051303) | 4.27820931 |
35 | centriole replication (GO:0007099) | 4.22539186 |
36 | positive regulation of gastrulation (GO:2000543) | 4.20943159 |
37 | binding of sperm to zona pellucida (GO:0007339) | 4.15977252 |
38 | CENP-A containing nucleosome assembly (GO:0034080) | 4.01668655 |
39 | metaphase plate congression (GO:0051310) | 4.01123117 |
40 | negative regulation of histone methylation (GO:0031061) | 3.93493247 |
41 | fertilization (GO:0009566) | 3.89935206 |
42 | protein localization to chromosome (GO:0034502) | 3.81361146 |
43 | single fertilization (GO:0007338) | 3.75333549 |
44 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.72759184 |
45 | DNA methylation (GO:0006306) | 3.71889695 |
46 | DNA alkylation (GO:0006305) | 3.71889695 |
47 | citrulline biosynthetic process (GO:0019240) | 3.64948309 |
48 | mitotic chromosome condensation (GO:0007076) | 3.62761138 |
49 | histone H2A acetylation (GO:0043968) | 3.62592988 |
50 | chromatin remodeling at centromere (GO:0031055) | 3.61592900 |
51 | sperm-egg recognition (GO:0035036) | 3.61574577 |
52 | regulation of histone H3-K4 methylation (GO:0051569) | 3.61307963 |
53 | male meiosis I (GO:0007141) | 3.60958415 |
54 | regulation of uterine smooth muscle contraction (GO:0070472) | 3.58581419 |
55 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.56773677 |
56 | regulation of meiosis (GO:0040020) | 3.53192077 |
57 | gene silencing (GO:0016458) | 3.48880713 |
58 | negative regulation of execution phase of apoptosis (GO:1900118) | 3.46216319 |
59 | positive regulation of reproductive process (GO:2000243) | 3.44969590 |
60 | chromosome organization involved in meiosis (GO:0070192) | 3.44422371 |
61 | positive regulation of histone methylation (GO:0031062) | 3.41615429 |
62 | gonadal mesoderm development (GO:0007506) | 3.41272398 |
63 | primitive streak formation (GO:0090009) | 3.40988545 |
64 | regulation of spindle organization (GO:0090224) | 3.39783333 |
65 | positive regulation of steroid hormone secretion (GO:2000833) | 3.39753791 |
66 | meiotic nuclear division (GO:0007126) | 3.36588640 |
67 | histone exchange (GO:0043486) | 3.30208996 |
68 | hyperosmotic salinity response (GO:0042538) | 3.29000161 |
69 | spermatid nucleus differentiation (GO:0007289) | 3.26337897 |
70 | relaxation of smooth muscle (GO:0044557) | 3.22714789 |
71 | regulation of reproductive process (GO:2000241) | 3.21677958 |
72 | synaptonemal complex assembly (GO:0007130) | 3.20802884 |
73 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.20772162 |
74 | regulation of hypersensitivity (GO:0002883) | 3.18613033 |
75 | regulation of corticosteroid hormone secretion (GO:2000846) | 3.18499578 |
76 | meiotic cell cycle process (GO:1903046) | 3.12633195 |
77 | regulation of spindle checkpoint (GO:0090231) | 3.11996749 |
78 | meiosis I (GO:0007127) | 3.06810744 |
79 | neuron fate determination (GO:0048664) | 3.04794668 |
80 | oogenesis (GO:0048477) | 3.01648678 |
81 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.01182207 |
82 | synaptonemal complex organization (GO:0070193) | 2.99242099 |
83 | DNA methylation or demethylation (GO:0044728) | 2.96572616 |
84 | regulation of meiotic cell cycle (GO:0051445) | 2.95749279 |
85 | cell-cell recognition (GO:0009988) | 2.92496507 |
86 | urate metabolic process (GO:0046415) | 2.90711604 |
87 | mismatch repair (GO:0006298) | 2.88950962 |
88 | DNA modification (GO:0006304) | 2.87596510 |
89 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.84130262 |
90 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.84130262 |
91 | DNA replication checkpoint (GO:0000076) | 2.80927840 |
92 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.79559759 |
93 | negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736) | 2.79218055 |
94 | base-excision repair, AP site formation (GO:0006285) | 2.78597629 |
95 | L-amino acid import (GO:0043092) | 2.78010623 |
96 | centriole assembly (GO:0098534) | 2.77763779 |
97 | DNA replication-independent nucleosome organization (GO:0034724) | 2.77749096 |
98 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.77749096 |
99 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.77378667 |
100 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.77204765 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.88088115 |
2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.18448790 |
3 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.24003302 |
4 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.54383538 |
5 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.43779834 |
6 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.33249214 |
7 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.31419239 |
8 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.21784566 |
9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.21072802 |
10 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.05395446 |
11 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.02899742 |
12 | EZH2_22144423_ChIP-Seq_EOC_Human | 13.8647916 |
13 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.92240650 |
14 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.87994415 |
15 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.85083878 |
16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.84260301 |
17 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.73358345 |
18 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.69846119 |
19 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.69846119 |
20 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.69846119 |
21 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.59856286 |
22 | VDR_22108803_ChIP-Seq_LS180_Human | 1.58464072 |
23 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.55478106 |
24 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.51843273 |
25 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.49208280 |
26 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.46850956 |
27 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.43768720 |
28 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.42649012 |
29 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.41414261 |
30 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.38423366 |
31 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.36216566 |
32 | GATA1_22025678_ChIP-Seq_K562_Human | 1.35125723 |
33 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.30263484 |
34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.30056132 |
35 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.27649580 |
36 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.26485401 |
37 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.26485401 |
38 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.25122053 |
39 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.23870360 |
40 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.23673244 |
41 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.22593709 |
42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.21735871 |
43 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.18960922 |
44 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.17520721 |
45 | EWS_26573619_Chip-Seq_HEK293_Human | 1.15482527 |
46 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.14206079 |
47 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.13543010 |
48 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.12669671 |
49 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.11373053 |
50 | FUS_26573619_Chip-Seq_HEK293_Human | 1.10797167 |
51 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08376136 |
52 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.08376136 |
53 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.08102092 |
54 | AR_25329375_ChIP-Seq_VCAP_Human | 1.07932398 |
55 | TCF4_23295773_ChIP-Seq_U87_Human | 1.03059165 |
56 | NCOR_22424771_ChIP-Seq_293T_Human | 1.02998235 |
57 | AR_20517297_ChIP-Seq_VCAP_Human | 1.00010705 |
58 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.99211035 |
59 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.99057439 |
60 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97814393 |
61 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97814393 |
62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.97715741 |
63 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.94597152 |
64 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.94170913 |
65 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.93967650 |
66 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.93785136 |
67 | P300_19829295_ChIP-Seq_ESCs_Human | 0.93395791 |
68 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.92729172 |
69 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.91239920 |
70 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90011027 |
71 | CBP_21632823_ChIP-Seq_H3396_Human | 0.89732497 |
72 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.89414662 |
73 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.87838111 |
74 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.87820614 |
75 | STAT3_23295773_ChIP-Seq_U87_Human | 0.87513512 |
76 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.86798341 |
77 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.86043984 |
78 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.85948818 |
79 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.85773803 |
80 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.84564692 |
81 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.84452558 |
82 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.83858641 |
83 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.83180451 |
84 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.82983940 |
85 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.82756874 |
86 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82530767 |
87 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.82004551 |
88 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.79165570 |
89 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.79132439 |
90 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.78339350 |
91 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.77592917 |
92 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.77409029 |
93 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.76742941 |
94 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.76532493 |
95 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.76121431 |
96 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.76021380 |
97 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.75387244 |
98 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.74892669 |
99 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.74892669 |
100 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.74670902 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003718_maternal_effect | 7.42315957 |
2 | MP0008877_abnormal_DNA_methylation | 5.27464510 |
3 | MP0006292_abnormal_olfactory_placode | 4.22907360 |
4 | MP0008789_abnormal_olfactory_epithelium | 3.54937508 |
5 | MP0002138_abnormal_hepatobiliary_system | 3.21076277 |
6 | MP0005377_hearing/vestibular/ear_phenot | 3.02255054 |
7 | MP0003878_abnormal_ear_physiology | 3.02255054 |
8 | MP0005395_other_phenotype | 3.00393957 |
9 | MP0005499_abnormal_olfactory_system | 2.98868130 |
10 | MP0005394_taste/olfaction_phenotype | 2.98868130 |
11 | MP0003890_abnormal_embryonic-extraembry | 2.80527345 |
12 | MP0002139_abnormal_hepatobiliary_system | 2.76464277 |
13 | MP0002234_abnormal_pharynx_morphology | 2.60413798 |
14 | MP0005360_urolithiasis | 2.56532814 |
15 | MP0003693_abnormal_embryo_hatching | 2.47274360 |
16 | MP0001929_abnormal_gametogenesis | 2.26955793 |
17 | MP0003699_abnormal_female_reproductive | 2.25671285 |
18 | MP0005410_abnormal_fertilization | 2.24667060 |
19 | MP0003879_abnormal_hair_cell | 2.14444498 |
20 | MP0002210_abnormal_sex_determination | 1.98523091 |
21 | MP0002160_abnormal_reproductive_system | 1.90125417 |
22 | MP0010094_abnormal_chromosome_stability | 1.90039828 |
23 | MP0003077_abnormal_cell_cycle | 1.82239922 |
24 | MP0008057_abnormal_DNA_replication | 1.72815745 |
25 | MP0003183_abnormal_peptide_metabolism | 1.72364325 |
26 | MP0010030_abnormal_orbit_morphology | 1.70273804 |
27 | MP0000653_abnormal_sex_gland | 1.67197807 |
28 | MP0001293_anophthalmia | 1.64719533 |
29 | MP0003111_abnormal_nucleus_morphology | 1.61363430 |
30 | MP0005389_reproductive_system_phenotype | 1.55173347 |
31 | MP0002161_abnormal_fertility/fecundity | 1.54929321 |
32 | MP0008058_abnormal_DNA_repair | 1.52371688 |
33 | MP0001119_abnormal_female_reproductive | 1.50328725 |
34 | MP0003252_abnormal_bile_duct | 1.42828842 |
35 | MP0005551_abnormal_eye_electrophysiolog | 1.37925980 |
36 | MP0010307_abnormal_tumor_latency | 1.36050698 |
37 | MP0003136_yellow_coat_color | 1.32936269 |
38 | MP0000631_abnormal_neuroendocrine_gland | 1.30714278 |
39 | MP0001145_abnormal_male_reproductive | 1.28328598 |
40 | MP0009379_abnormal_foot_pigmentation | 1.28259019 |
41 | MP0003698_abnormal_male_reproductive | 1.23085424 |
42 | MP0008932_abnormal_embryonic_tissue | 1.22334863 |
43 | MP0005075_abnormal_melanosome_morpholog | 1.20745412 |
44 | MP0000427_abnormal_hair_cycle | 1.12965817 |
45 | MP0002272_abnormal_nervous_system | 1.12560112 |
46 | MP0005646_abnormal_pituitary_gland | 1.09696184 |
47 | MP0003195_calcinosis | 1.06321805 |
48 | MP0000566_synostosis | 1.04795244 |
49 | MP0006276_abnormal_autonomic_nervous | 1.01788290 |
50 | MP0001730_embryonic_growth_arrest | 1.01753226 |
51 | MP0004142_abnormal_muscle_tone | 0.99948123 |
52 | MP0003786_premature_aging | 0.99552571 |
53 | MP0006072_abnormal_retinal_apoptosis | 0.98524882 |
54 | MP0005647_abnormal_sex_gland | 0.94477981 |
55 | MP0001919_abnormal_reproductive_system | 0.94319584 |
56 | MP0001986_abnormal_taste_sensitivity | 0.94118746 |
57 | MP0003119_abnormal_digestive_system | 0.93865429 |
58 | MP0001984_abnormal_olfaction | 0.89740549 |
59 | MP0001963_abnormal_hearing_physiology | 0.87994158 |
60 | MP0000678_abnormal_parathyroid_gland | 0.87287199 |
61 | MP0010234_abnormal_vibrissa_follicle | 0.86950935 |
62 | MP0004957_abnormal_blastocyst_morpholog | 0.85912042 |
63 | MP0000569_abnormal_digit_pigmentation | 0.85291225 |
64 | MP0002928_abnormal_bile_duct | 0.84092747 |
65 | MP0000762_abnormal_tongue_morphology | 0.82423570 |
66 | MP0001486_abnormal_startle_reflex | 0.78919547 |
67 | MP0008995_early_reproductive_senescence | 0.78076665 |
68 | MP0005319_abnormal_enzyme/_coenzyme | 0.76231778 |
69 | MP0001324_abnormal_eye_pigmentation | 0.75708990 |
70 | MP0001664_abnormal_digestion | 0.75185889 |
71 | MP0002735_abnormal_chemical_nociception | 0.74160114 |
72 | MP0000015_abnormal_ear_pigmentation | 0.73654097 |
73 | MP0003950_abnormal_plasma_membrane | 0.73353274 |
74 | MP0001485_abnormal_pinna_reflex | 0.71774192 |
75 | MP0003121_genomic_imprinting | 0.71117924 |
76 | MP0004215_abnormal_myocardial_fiber | 0.70902791 |
77 | MP0005380_embryogenesis_phenotype | 0.69797959 |
78 | MP0001672_abnormal_embryogenesis/_devel | 0.69797959 |
79 | MP0005085_abnormal_gallbladder_physiolo | 0.68446289 |
80 | MP0005174_abnormal_tail_pigmentation | 0.65255897 |
81 | MP0004145_abnormal_muscle_electrophysio | 0.65132472 |
82 | MP0005671_abnormal_response_to | 0.62347984 |
83 | MP0002233_abnormal_nose_morphology | 0.61379938 |
84 | MP0002090_abnormal_vision | 0.61076154 |
85 | MP0002638_abnormal_pupillary_reflex | 0.60616966 |
86 | MP0002102_abnormal_ear_morphology | 0.60326657 |
87 | MP0009333_abnormal_splenocyte_physiolog | 0.59824855 |
88 | MP0010368_abnormal_lymphatic_system | 0.59724748 |
89 | MP0009840_abnormal_foam_cell | 0.59305774 |
90 | MP0000026_abnormal_inner_ear | 0.59047257 |
91 | MP0003567_abnormal_fetal_cardiomyocyte | 0.56496970 |
92 | MP0000049_abnormal_middle_ear | 0.55834124 |
93 | MP0004019_abnormal_vitamin_homeostasis | 0.54101153 |
94 | MP0003959_abnormal_lean_body | 0.53774729 |
95 | MP0010678_abnormal_skin_adnexa | 0.53550111 |
96 | MP0001765_abnormal_ion_homeostasis | 0.49376425 |
97 | MP0001666_abnormal_nutrient_absorption | 0.48836177 |
98 | MP0005503_abnormal_tendon_morphology | 0.48466471 |
99 | MP0002751_abnormal_autonomic_nervous | 0.47981457 |
100 | MP0002229_neurodegeneration | 0.47857878 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Supernumerary spleens (HP:0009799) | 6.02906620 |
2 | Generalized aminoaciduria (HP:0002909) | 5.05117629 |
3 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 4.23066494 |
4 | Abnormality of abdominal situs (HP:0011620) | 4.06744140 |
5 | Abdominal situs inversus (HP:0003363) | 4.06744140 |
6 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 4.01155546 |
7 | Hypoplasia of the fovea (HP:0007750) | 4.01155546 |
8 | Absent septum pellucidum (HP:0001331) | 3.85643837 |
9 | Septo-optic dysplasia (HP:0100842) | 3.82175255 |
10 | Impulsivity (HP:0100710) | 3.75150393 |
11 | Hypophosphatemic rickets (HP:0004912) | 3.72388117 |
12 | Male infertility (HP:0003251) | 3.63141511 |
13 | Lip pit (HP:0100267) | 3.44153092 |
14 | Abnormality of the fovea (HP:0000493) | 3.42811408 |
15 | Gonadotropin excess (HP:0000837) | 3.41854455 |
16 | Infertility (HP:0000789) | 3.33831837 |
17 | Median cleft lip (HP:0000161) | 3.31681128 |
18 | Anterior segment dysgenesis (HP:0007700) | 3.27240487 |
19 | Premature ovarian failure (HP:0008209) | 3.26178665 |
20 | Oligodactyly (hands) (HP:0001180) | 3.23732497 |
21 | Abnormal gallbladder physiology (HP:0012438) | 3.19484889 |
22 | Cholecystitis (HP:0001082) | 3.19484889 |
23 | Short tibia (HP:0005736) | 3.17136463 |
24 | Azoospermia (HP:0000027) | 3.15681922 |
25 | Facial hemangioma (HP:0000329) | 3.13758691 |
26 | Abnormality of the septum pellucidum (HP:0007375) | 3.11273935 |
27 | Proximal tubulopathy (HP:0000114) | 3.08129069 |
28 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.07003144 |
29 | Osteomalacia (HP:0002749) | 3.02292071 |
30 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.97952507 |
31 | Abnormality of the labia minora (HP:0012880) | 2.95100114 |
32 | Abnormal ciliary motility (HP:0012262) | 2.93414445 |
33 | Chromsome breakage (HP:0040012) | 2.93034665 |
34 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.86800055 |
35 | Pancreatic cysts (HP:0001737) | 2.80389522 |
36 | Myokymia (HP:0002411) | 2.74690710 |
37 | Bile duct proliferation (HP:0001408) | 2.73001364 |
38 | Abnormal biliary tract physiology (HP:0012439) | 2.73001364 |
39 | Aplastic anemia (HP:0001915) | 2.72901799 |
40 | Fair hair (HP:0002286) | 2.69101570 |
41 | Severe visual impairment (HP:0001141) | 2.68378591 |
42 | Pancreatic fibrosis (HP:0100732) | 2.64760873 |
43 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.60749108 |
44 | Abnormal spermatogenesis (HP:0008669) | 2.59520279 |
45 | Hypokinesia (HP:0002375) | 2.59441900 |
46 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.58654385 |
47 | Absent/shortened dynein arms (HP:0200106) | 2.58654385 |
48 | Pendular nystagmus (HP:0012043) | 2.54540724 |
49 | Molar tooth sign on MRI (HP:0002419) | 2.46041459 |
50 | Abnormality of midbrain morphology (HP:0002418) | 2.46041459 |
51 | Decreased central vision (HP:0007663) | 2.41935912 |
52 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.39471573 |
53 | Attenuation of retinal blood vessels (HP:0007843) | 2.36622940 |
54 | Papillary thyroid carcinoma (HP:0002895) | 2.32121914 |
55 | True hermaphroditism (HP:0010459) | 2.28694167 |
56 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.24972451 |
57 | Oligodactyly (HP:0012165) | 2.23315275 |
58 | Cone-rod dystrophy (HP:0000548) | 2.22461261 |
59 | Aplasia of the musculature (HP:0100854) | 2.21031936 |
60 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 2.19424161 |
61 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 2.18782977 |
62 | Optic nerve hypoplasia (HP:0000609) | 2.17442634 |
63 | Rhinitis (HP:0012384) | 2.17142923 |
64 | Urethral obstruction (HP:0000796) | 2.13518368 |
65 | Dysdiadochokinesis (HP:0002075) | 2.12126167 |
66 | Renal cortical cysts (HP:0000803) | 2.11406846 |
67 | Stillbirth (HP:0003826) | 2.10674741 |
68 | Capillary hemangiomas (HP:0005306) | 2.04553065 |
69 | Pulmonary fibrosis (HP:0002206) | 2.03414036 |
70 | Cystic liver disease (HP:0006706) | 2.02809504 |
71 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.01666114 |
72 | Abnormality of the anterior horn cell (HP:0006802) | 2.01664230 |
73 | Degeneration of anterior horn cells (HP:0002398) | 2.01664230 |
74 | Secondary amenorrhea (HP:0000869) | 2.00082349 |
75 | Anencephaly (HP:0002323) | 1.99661809 |
76 | Enlarged penis (HP:0000040) | 1.99509222 |
77 | Posterior subcapsular cataract (HP:0007787) | 1.99099459 |
78 | Wrist flexion contracture (HP:0001239) | 1.99028959 |
79 | Abnormal lung lobation (HP:0002101) | 1.98351444 |
80 | Malnutrition (HP:0004395) | 1.97450778 |
81 | Metaphyseal irregularity (HP:0003025) | 1.97251073 |
82 | Congenital sensorineural hearing impairment (HP:0008527) | 1.95627250 |
83 | Rickets (HP:0002748) | 1.94357675 |
84 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.93084889 |
85 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.92102774 |
86 | Generalized hypopigmentation of hair (HP:0011358) | 1.90876161 |
87 | Decreased circulating renin level (HP:0003351) | 1.90644598 |
88 | Abnormality of urine glucose concentration (HP:0011016) | 1.89949640 |
89 | Glycosuria (HP:0003076) | 1.89949640 |
90 | Spinal muscular atrophy (HP:0007269) | 1.89628026 |
91 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.88300879 |
92 | Skin pits (HP:0100276) | 1.85202056 |
93 | Maternal diabetes (HP:0009800) | 1.85040992 |
94 | Birth length less than 3rd percentile (HP:0003561) | 1.83760888 |
95 | Small intestinal stenosis (HP:0012848) | 1.82407258 |
96 | Duodenal stenosis (HP:0100867) | 1.82407258 |
97 | Meckel diverticulum (HP:0002245) | 1.81068960 |
98 | Preaxial hand polydactyly (HP:0001177) | 1.77786112 |
99 | Colon cancer (HP:0003003) | 1.74340849 |
100 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.72447192 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP3K9 | 4.19904749 |
2 | TAOK3 | 4.03346293 |
3 | MAP3K13 | 3.86417892 |
4 | ARAF | 3.73820986 |
5 | BUB1 | 3.34554528 |
6 | TXK | 3.19137072 |
7 | TTK | 3.02164074 |
8 | AURKA | 2.63431563 |
9 | NEK6 | 2.61677449 |
10 | CDK19 | 2.54008342 |
11 | ZAK | 2.40051428 |
12 | STK24 | 2.20747563 |
13 | NTRK2 | 2.08001804 |
14 | CDK9 | 2.00018838 |
15 | MOS | 1.93290415 |
16 | KDR | 1.85001315 |
17 | TLK1 | 1.80510727 |
18 | MET | 1.77461519 |
19 | MUSK | 1.74410626 |
20 | BRAF | 1.68686050 |
21 | VRK1 | 1.66563795 |
22 | TESK2 | 1.64467516 |
23 | CDC7 | 1.62169960 |
24 | TRIM28 | 1.49714432 |
25 | PLK1 | 1.43383511 |
26 | TYRO3 | 1.34856220 |
27 | MST4 | 1.34698825 |
28 | TNK2 | 1.31325180 |
29 | PRKCI | 1.29887632 |
30 | NEK9 | 1.24493797 |
31 | KSR2 | 1.20494526 |
32 | CDK12 | 1.18158647 |
33 | MAPKAPK3 | 1.14199856 |
34 | TGFBR1 | 1.09662706 |
35 | PIM1 | 1.08252212 |
36 | TNIK | 1.07426570 |
37 | CDK7 | 1.04842410 |
38 | MELK | 1.04267895 |
39 | BCKDK | 1.02637757 |
40 | PLK3 | 1.01537479 |
41 | PIK3CG | 0.99609818 |
42 | RAF1 | 0.99475339 |
43 | TIE1 | 0.86596209 |
44 | NEK2 | 0.85567028 |
45 | BRSK2 | 0.85386802 |
46 | BMPR1B | 0.84375384 |
47 | NUAK1 | 0.79956805 |
48 | STK3 | 0.79500756 |
49 | EIF2AK3 | 0.79268499 |
50 | CHEK1 | 0.76966546 |
51 | AURKB | 0.75705508 |
52 | MAP3K8 | 0.75548592 |
53 | KSR1 | 0.73715460 |
54 | BRSK1 | 0.72944398 |
55 | MAP3K5 | 0.71794028 |
56 | ADRBK2 | 0.71149557 |
57 | RPS6KA4 | 0.70483033 |
58 | PAK1 | 0.67796131 |
59 | NME1 | 0.64653624 |
60 | ATR | 0.63921659 |
61 | WNK3 | 0.60902861 |
62 | CAMK1D | 0.58751739 |
63 | MAP3K4 | 0.58617910 |
64 | CSNK1G1 | 0.55690721 |
65 | PLK4 | 0.54344594 |
66 | NTRK3 | 0.53877942 |
67 | CDK2 | 0.53119092 |
68 | CSNK1G3 | 0.52979015 |
69 | CHEK2 | 0.51429513 |
70 | MARK3 | 0.50705235 |
71 | WNK1 | 0.50256391 |
72 | PKN1 | 0.50028744 |
73 | VRK2 | 0.47486158 |
74 | GRK1 | 0.44784723 |
75 | CAMK2A | 0.43686947 |
76 | ITK | 0.43652998 |
77 | ATM | 0.42906645 |
78 | CDK1 | 0.40549905 |
79 | PRKACA | 0.39873703 |
80 | STK39 | 0.39169746 |
81 | CSNK1D | 0.38793043 |
82 | PRKG1 | 0.36391978 |
83 | TESK1 | 0.33034257 |
84 | OXSR1 | 0.32509886 |
85 | CDK8 | 0.32225607 |
86 | TRPM7 | 0.31443514 |
87 | CSNK1E | 0.30953596 |
88 | MAP3K12 | 0.30470784 |
89 | MAPK13 | 0.29416797 |
90 | WEE1 | 0.28605725 |
91 | LCK | 0.27152902 |
92 | PRKCZ | 0.27042244 |
93 | ACVR1B | 0.26892902 |
94 | NEK1 | 0.26793055 |
95 | TGFBR2 | 0.26576083 |
96 | GRK6 | 0.26303546 |
97 | PRKACB | 0.25132142 |
98 | STK10 | 0.24801124 |
99 | CSNK1A1L | 0.24020777 |
100 | JAK3 | 0.23129309 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Basal transcription factors_Homo sapiens_hsa03022 | 4.24548861 |
2 | Cell cycle_Homo sapiens_hsa04110 | 3.71448305 |
3 | Mismatch repair_Homo sapiens_hsa03430 | 3.17783560 |
4 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 3.16917155 |
5 | Homologous recombination_Homo sapiens_hsa03440 | 3.00776760 |
6 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.00339482 |
7 | Oocyte meiosis_Homo sapiens_hsa04114 | 2.85723594 |
8 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 2.82450706 |
9 | Phototransduction_Homo sapiens_hsa04744 | 2.70571114 |
10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.64117008 |
11 | RNA degradation_Homo sapiens_hsa03018 | 2.49728457 |
12 | Base excision repair_Homo sapiens_hsa03410 | 2.46610661 |
13 | DNA replication_Homo sapiens_hsa03030 | 2.29631093 |
14 | RNA polymerase_Homo sapiens_hsa03020 | 2.16876050 |
15 | RNA transport_Homo sapiens_hsa03013 | 2.10536676 |
16 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.08495684 |
17 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 2.03123282 |
18 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.92272899 |
19 | Olfactory transduction_Homo sapiens_hsa04740 | 1.91565924 |
20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.91522157 |
21 | Proteasome_Homo sapiens_hsa03050 | 1.90365518 |
22 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.86445162 |
23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.52822672 |
24 | Circadian rhythm_Homo sapiens_hsa04710 | 1.47779323 |
25 | Nicotine addiction_Homo sapiens_hsa05033 | 1.43757910 |
26 | Taste transduction_Homo sapiens_hsa04742 | 1.35699681 |
27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.31369060 |
28 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.25745027 |
29 | ABC transporters_Homo sapiens_hsa02010 | 1.19977778 |
30 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.19856753 |
31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.19291928 |
32 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.10495039 |
33 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.08942052 |
34 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.08777611 |
35 | Ribosome_Homo sapiens_hsa03010 | 1.04976446 |
36 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.04394841 |
37 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.03268450 |
38 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.97477614 |
39 | Huntingtons disease_Homo sapiens_hsa05016 | 0.97175361 |
40 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.96084147 |
41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.94774428 |
42 | Purine metabolism_Homo sapiens_hsa00230 | 0.92942956 |
43 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.92666034 |
44 | Parkinsons disease_Homo sapiens_hsa05012 | 0.86544529 |
45 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.86378381 |
46 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.83529973 |
47 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.83074128 |
48 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82804368 |
49 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.79898770 |
50 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.79284091 |
51 | Morphine addiction_Homo sapiens_hsa05032 | 0.78482437 |
52 | Protein export_Homo sapiens_hsa03060 | 0.75849566 |
53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.75592634 |
54 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.74666857 |
55 | Allograft rejection_Homo sapiens_hsa05330 | 0.71461022 |
56 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.69287475 |
57 | Gap junction_Homo sapiens_hsa04540 | 0.67410498 |
58 | Spliceosome_Homo sapiens_hsa03040 | 0.63082264 |
59 | GABAergic synapse_Homo sapiens_hsa04727 | 0.62793737 |
60 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.58025518 |
61 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.57796859 |
62 | Retinol metabolism_Homo sapiens_hsa00830 | 0.56146838 |
63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.55371684 |
64 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.55354965 |
65 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.54285225 |
66 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.53236545 |
67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.50715241 |
68 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.46815356 |
69 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.45279013 |
70 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.43974661 |
71 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.40980361 |
72 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39215845 |
73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.38990740 |
74 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.36268946 |
75 | HTLV-I infection_Homo sapiens_hsa05166 | 0.35626611 |
76 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.34393237 |
77 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34387577 |
78 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31742656 |
79 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.31216356 |
80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30357559 |
81 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.30165505 |
82 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.29732400 |
83 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.29723117 |
84 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.28785680 |
85 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.27643720 |
86 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.27586683 |
87 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.26686017 |
88 | Alzheimers disease_Homo sapiens_hsa05010 | 0.24014553 |
89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.23552877 |
90 | Bile secretion_Homo sapiens_hsa04976 | 0.21273062 |
91 | Metabolic pathways_Homo sapiens_hsa01100 | 0.21142909 |
92 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.20474153 |
93 | Sulfur relay system_Homo sapiens_hsa04122 | 0.19970747 |
94 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.19723082 |
95 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.16801962 |
96 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.16135224 |
97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.13854625 |
98 | Thyroid cancer_Homo sapiens_hsa05216 | 0.13632511 |
99 | Peroxisome_Homo sapiens_hsa04146 | 0.12598424 |
100 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.12143171 |