ALG1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)7.90975305
2female mating behavior (GO:0060180)6.83628967
3relaxation of smooth muscle (GO:0044557)5.80629203
4meiotic chromosome segregation (GO:0045132)5.01466737
5behavioral response to nicotine (GO:0035095)4.45591441
6negative regulation of T cell receptor signaling pathway (GO:0050860)4.36321289
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.22912675
8indolalkylamine metabolic process (GO:0006586)4.10438760
9DNA double-strand break processing (GO:0000729)3.95518153
10protein-chromophore linkage (GO:0018298)3.84756442
11negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.75223887
12deoxyribonucleotide catabolic process (GO:0009264)3.74052026
13amino acid salvage (GO:0043102)3.70135669
14L-methionine salvage (GO:0071267)3.70135669
15L-methionine biosynthetic process (GO:0071265)3.70135669
16negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.66742927
17detection of light stimulus involved in visual perception (GO:0050908)3.63084368
18detection of light stimulus involved in sensory perception (GO:0050962)3.63084368
19multicellular organism reproduction (GO:0032504)3.62194385
20indole-containing compound catabolic process (GO:0042436)3.51091673
21indolalkylamine catabolic process (GO:0046218)3.51091673
22tryptophan catabolic process (GO:0006569)3.51091673
23coenzyme catabolic process (GO:0009109)3.50523333
24high-density lipoprotein particle remodeling (GO:0034375)3.43268201
25behavioral response to ethanol (GO:0048149)3.40961382
26methionine biosynthetic process (GO:0009086)3.39090336
27protein localization to cilium (GO:0061512)3.38912698
28deoxyribose phosphate catabolic process (GO:0046386)3.37711652
29neural tube formation (GO:0001841)3.34039866
30response to pheromone (GO:0019236)3.33246849
31tryptophan metabolic process (GO:0006568)3.33007704
32sperm motility (GO:0030317)3.32979282
33otic vesicle formation (GO:0030916)3.32442100
34cilium or flagellum-dependent cell motility (GO:0001539)3.32393872
35dopamine transport (GO:0015872)3.32365709
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31465931
37tachykinin receptor signaling pathway (GO:0007217)3.30367353
38transmission of nerve impulse (GO:0019226)3.24761473
39methionine metabolic process (GO:0006555)3.22400903
40pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.20140534
41UMP metabolic process (GO:0046049)3.20140534
42pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.20140534
43UMP biosynthetic process (GO:0006222)3.20140534
44reverse cholesterol transport (GO:0043691)3.19259483
45multicellular organismal reproductive behavior (GO:0033057)3.16660933
46long term synaptic depression (GO:0060292)3.11425723
47cardiolipin metabolic process (GO:0032048)3.08300320
48regulation of hippo signaling (GO:0035330)3.03986412
49xenobiotic catabolic process (GO:0042178)3.03767053
50adenosine metabolic process (GO:0046085)2.98123285
51purine deoxyribonucleotide catabolic process (GO:0009155)2.96862042
52negative regulation of lipase activity (GO:0060192)2.95034444
53somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94773180
54somatic hypermutation of immunoglobulin genes (GO:0016446)2.94773180
55ectoderm development (GO:0007398)2.94305666
56amine catabolic process (GO:0009310)2.90497821
57cellular biogenic amine catabolic process (GO:0042402)2.90497821
58pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.89429875
59somite rostral/caudal axis specification (GO:0032525)2.88042021
60mast cell activation involved in immune response (GO:0002279)2.85366096
61mast cell degranulation (GO:0043303)2.85366096
62sulfation (GO:0051923)2.81991540
63photoreceptor cell maintenance (GO:0045494)2.80118321
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.76914893
65auditory receptor cell stereocilium organization (GO:0060088)2.74847195
66regulation of T cell receptor signaling pathway (GO:0050856)2.74527377
67regulation of Golgi to plasma membrane protein transport (GO:0042996)2.73653106
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72478310
69S-adenosylmethionine metabolic process (GO:0046500)2.72297368
70pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72267465
71negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.71543163
72limb bud formation (GO:0060174)2.71106789
73relaxation of muscle (GO:0090075)2.65620837
74male meiosis (GO:0007140)2.65455659
75nitric oxide mediated signal transduction (GO:0007263)2.64955006
76neuronal action potential (GO:0019228)2.63006890
77misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.62970817
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61586986
79detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.61107121
80axoneme assembly (GO:0035082)2.60125134
81regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.59325122
82fusion of sperm to egg plasma membrane (GO:0007342)2.58180179
83regulation of DNA-templated transcription, initiation (GO:2000142)2.57705449
84indole-containing compound metabolic process (GO:0042430)2.57142273
85aspartate family amino acid catabolic process (GO:0009068)2.56922902
86regulation of megakaryocyte differentiation (GO:0045652)2.56681591
87cilium morphogenesis (GO:0060271)2.54994777
88histone H3-K9 methylation (GO:0051567)2.53405742
89positive regulation of male gonad development (GO:2000020)2.52695037
90amine biosynthetic process (GO:0009309)2.52389297
91base-excision repair, AP site formation (GO:0006285)2.51825149
92left/right axis specification (GO:0070986)2.51292212
93double-strand break repair via homologous recombination (GO:0000724)2.50132068
94rhodopsin mediated signaling pathway (GO:0016056)2.49423885
95intraciliary transport (GO:0042073)2.49283630
96piRNA metabolic process (GO:0034587)2.48379960
97kynurenine metabolic process (GO:0070189)2.48204486
98regulation of female gonad development (GO:2000194)2.47918607
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.47724768
100recombinational repair (GO:0000725)2.46499898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.03410347
2GBX2_23144817_ChIP-Seq_PC3_Human3.47201883
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22108725
4VDR_22108803_ChIP-Seq_LS180_Human2.55628611
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54825457
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43448704
7ZNF274_21170338_ChIP-Seq_K562_Hela2.39673866
8EZH2_22144423_ChIP-Seq_EOC_Human2.37461002
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32414587
10FUS_26573619_Chip-Seq_HEK293_Human2.21061628
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17490460
12* P300_19829295_ChIP-Seq_ESCs_Human2.16528803
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13034247
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12359073
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07411462
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05012174
17ER_23166858_ChIP-Seq_MCF-7_Human1.99669103
18EWS_26573619_Chip-Seq_HEK293_Human1.99642150
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97293312
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96272892
21IRF1_19129219_ChIP-ChIP_H3396_Human1.94011494
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90475550
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88770924
24* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.86757952
25SMAD4_21799915_ChIP-Seq_A2780_Human1.83052619
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79404932
27CBP_20019798_ChIP-Seq_JUKART_Human1.79404932
28STAT3_23295773_ChIP-Seq_U87_Human1.78587920
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77443286
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76856237
31TCF4_23295773_ChIP-Seq_U87_Human1.69011098
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67917974
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.64159451
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62051584
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59060703
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59060703
37TAF15_26573619_Chip-Seq_HEK293_Human1.58918568
38NANOG_19829295_ChIP-Seq_ESCs_Human1.55592641
39SOX2_19829295_ChIP-Seq_ESCs_Human1.55592641
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.55382346
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47556250
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46390345
43AR_25329375_ChIP-Seq_VCAP_Human1.46129353
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.46022149
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43257957
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42543489
47BCAT_22108803_ChIP-Seq_LS180_Human1.42362412
48TCF4_22108803_ChIP-Seq_LS180_Human1.33956032
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31424238
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31047692
51* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30901827
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.30857829
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.29437260
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28291735
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28256243
56TP53_22573176_ChIP-Seq_HFKS_Human1.28088456
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.27192154
58AR_21572438_ChIP-Seq_LNCaP_Human1.26551079
59* PRDM14_20953172_ChIP-Seq_ESCs_Human1.26313114
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.24638704
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.24013349
62RUNX2_22187159_ChIP-Seq_PCA_Human1.23433665
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20462203
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19880611
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.19880611
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19212152
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18100978
68MYC_18940864_ChIP-ChIP_HL60_Human1.17328566
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.16508578
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.15958933
71CDX2_22108803_ChIP-Seq_LS180_Human1.15438087
72HTT_18923047_ChIP-ChIP_STHdh_Human1.14919232
73HOXB7_26014856_ChIP-Seq_BT474_Human1.14449694
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13974135
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12054698
76GATA3_26560356_Chip-Seq_TH2_Human1.11388783
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09293437
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09048014
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08783816
80AR_20517297_ChIP-Seq_VCAP_Human1.08260797
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.07950399
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06164167
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.03719820
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.03107335
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02112872
86SCL_19346495_ChIP-Seq_HPC-7_Human1.01379933
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.01344994
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00926348
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00844747
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.98803322
91TP53_18474530_ChIP-ChIP_U2OS_Human0.97130649
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95859921
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.95082883
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94020793
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.93972908
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92811451
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92002812
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92002812
99KDM2B_26808549_Chip-Seq_REH_Human0.91862559
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.90978477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.15379546
2MP0009780_abnormal_chondrocyte_physiolo4.43460969
3MP0009697_abnormal_copulation4.24239669
4MP0002132_abnormal_respiratory_system3.53246733
5MP0000372_irregular_coat_pigmentation3.15841868
6MP0006072_abnormal_retinal_apoptosis2.74878572
7MP0008004_abnormal_stomach_pH2.72292767
8MP0005551_abnormal_eye_electrophysiolog2.69270753
9MP0006276_abnormal_autonomic_nervous2.67937428
10MP0004043_abnormal_pH_regulation2.58085739
11MP0003879_abnormal_hair_cell2.49231122
12MP0005410_abnormal_fertilization2.38341273
13MP0002102_abnormal_ear_morphology2.36991933
14MP0002163_abnormal_gland_morphology2.36887389
15MP0008057_abnormal_DNA_replication2.29604444
16MP0006054_spinal_hemorrhage2.15139742
17MP0005646_abnormal_pituitary_gland2.15074939
18MP0001984_abnormal_olfaction2.13676140
19MP0008877_abnormal_DNA_methylation2.11156974
20MP0002090_abnormal_vision2.00950959
21MP0005464_abnormal_platelet_physiology1.92376955
22MP0005253_abnormal_eye_physiology1.86361684
23MP0001986_abnormal_taste_sensitivity1.83761459
24MP0005187_abnormal_penis_morphology1.78697896
25MP0004381_abnormal_hair_follicle1.70456587
26MP0001485_abnormal_pinna_reflex1.61800745
27MP0005360_urolithiasis1.56947323
28MP0005075_abnormal_melanosome_morpholog1.46931030
29MP0002736_abnormal_nociception_after1.46188067
30MP0005171_absent_coat_pigmentation1.45690503
31MP0000383_abnormal_hair_follicle1.44512980
32MP0001968_abnormal_touch/_nociception1.39533112
33MP0008775_abnormal_heart_ventricle1.39424908
34MP0003123_paternal_imprinting1.37335987
35MP0009046_muscle_twitch1.33843526
36MP0004885_abnormal_endolymph1.32102593
37MP0001501_abnormal_sleep_pattern1.30418533
38MP0008872_abnormal_physiological_respon1.22457187
39MP0005379_endocrine/exocrine_gland_phen1.21279935
40MP0000230_abnormal_systemic_arterial1.20768543
41MP0003878_abnormal_ear_physiology1.18574375
42MP0005377_hearing/vestibular/ear_phenot1.18574375
43MP0002653_abnormal_ependyma_morphology1.15439834
44MP0010329_abnormal_lipoprotein_level1.13989032
45MP0008875_abnormal_xenobiotic_pharmacok1.12825969
46MP0006035_abnormal_mitochondrial_morpho1.09407802
47MP0004085_abnormal_heartbeat1.08555238
48MP0002876_abnormal_thyroid_physiology1.07675558
49MP0006292_abnormal_olfactory_placode1.05581741
50MP0003698_abnormal_male_reproductive1.05321956
51MP0002160_abnormal_reproductive_system1.01814679
52MP0000631_abnormal_neuroendocrine_gland1.01013243
53MP0000647_abnormal_sebaceous_gland1.00935751
54MP0003121_genomic_imprinting0.99514047
55MP0005167_abnormal_blood-brain_barrier0.98454370
56MP0001963_abnormal_hearing_physiology0.96467398
57MP0003787_abnormal_imprinting0.94176131
58MP0003718_maternal_effect0.93030401
59MP0004147_increased_porphyrin_level0.91936349
60MP0001756_abnormal_urination0.91707845
61MP0002938_white_spotting0.89615912
62MP0001486_abnormal_startle_reflex0.87318998
63MP0000465_gastrointestinal_hemorrhage0.84602322
64MP0000538_abnormal_urinary_bladder0.84044826
65MP0003195_calcinosis0.81089052
66MP0001293_anophthalmia0.80814747
67MP0002272_abnormal_nervous_system0.80437380
68MP0010030_abnormal_orbit_morphology0.80268249
69MP0005391_vision/eye_phenotype0.80095783
70MP0009745_abnormal_behavioral_response0.79343750
71MP0003638_abnormal_response/metabolism_0.76943438
72MP0010386_abnormal_urinary_bladder0.76551121
73MP0003119_abnormal_digestive_system0.74553845
74MP0005174_abnormal_tail_pigmentation0.73023853
75MP0001929_abnormal_gametogenesis0.72217957
76MP0002210_abnormal_sex_determination0.71479091
77MP0003890_abnormal_embryonic-extraembry0.70127153
78MP0002735_abnormal_chemical_nociception0.69134835
79MP0001324_abnormal_eye_pigmentation0.69093580
80MP0000427_abnormal_hair_cycle0.67564024
81MP0003880_abnormal_central_pattern0.67288836
82MP0002572_abnormal_emotion/affect_behav0.66310316
83MP0004133_heterotaxia0.66217463
84MP0000653_abnormal_sex_gland0.66036049
85MP0005195_abnormal_posterior_eye0.65372372
86MP0004084_abnormal_cardiac_muscle0.65364136
87MP0002638_abnormal_pupillary_reflex0.65107235
88MP0003045_fibrosis0.64619789
89MP0004264_abnormal_extraembryonic_tissu0.64085148
90MP0002233_abnormal_nose_morphology0.64001062
91MP0001529_abnormal_vocalization0.60944646
92MP0005395_other_phenotype0.60527036
93MP0003950_abnormal_plasma_membrane0.59524344
94MP0003938_abnormal_ear_development0.59433071
95MP0004215_abnormal_myocardial_fiber0.58808615
96MP0002752_abnormal_somatic_nervous0.58123008
97MP0003137_abnormal_impulse_conducting0.57537230
98MP0003122_maternal_imprinting0.57516967
99MP0005394_taste/olfaction_phenotype0.57320161
100MP0005499_abnormal_olfactory_system0.57320161

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.86580427
2True hermaphroditism (HP:0010459)4.57321435
3Pancreatic cysts (HP:0001737)4.08382999
4Pancreatic fibrosis (HP:0100732)4.00258714
5Abnormal rod and cone electroretinograms (HP:0008323)3.71567365
6Short chin (HP:0000331)3.70051781
7Abnormality of midbrain morphology (HP:0002418)3.43973242
8Molar tooth sign on MRI (HP:0002419)3.43973242
9Nephronophthisis (HP:0000090)3.40781029
10Concave nail (HP:0001598)3.33168905
11Attenuation of retinal blood vessels (HP:0007843)3.27425663
12Severe visual impairment (HP:0001141)3.18790276
13Cystic liver disease (HP:0006706)3.13642169
14Abolished electroretinogram (ERG) (HP:0000550)3.05290897
15Abnormal biliary tract physiology (HP:0012439)3.02981473
16Bile duct proliferation (HP:0001408)3.02981473
17Aplasia/Hypoplasia of the fovea (HP:0008060)2.97283780
18Hypoplasia of the fovea (HP:0007750)2.97283780
19Progressive inability to walk (HP:0002505)2.91846820
20Abnormality of the renal medulla (HP:0100957)2.90302735
21Hypothermia (HP:0002045)2.89459853
22Conical tooth (HP:0000698)2.84933537
23Thyroiditis (HP:0100646)2.73583846
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.68500865
25Male pseudohermaphroditism (HP:0000037)2.66793080
26Bony spicule pigmentary retinopathy (HP:0007737)2.66322779
27Chronic hepatic failure (HP:0100626)2.55497253
28Gaze-evoked nystagmus (HP:0000640)2.52737432
29Postaxial foot polydactyly (HP:0001830)2.52078526
30Anencephaly (HP:0002323)2.51690753
31Abnormality of the fovea (HP:0000493)2.51545535
32Abnormality of the renal cortex (HP:0011035)2.46787183
33Menorrhagia (HP:0000132)2.43972280
34Medial flaring of the eyebrow (HP:0010747)2.42396460
35Severe combined immunodeficiency (HP:0004430)2.39051926
36Cerebellar dysplasia (HP:0007033)2.34573718
37Inability to walk (HP:0002540)2.28088403
38Facial diplegia (HP:0001349)2.28014677
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.27346103
40Congenital primary aphakia (HP:0007707)2.24851742
41Abnormality of macular pigmentation (HP:0008002)2.24505701
42Abnormality of eosinophils (HP:0001879)2.23899161
43Rimmed vacuoles (HP:0003805)2.23678612
44Sclerocornea (HP:0000647)2.21356529
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.20659021
46Hypoproteinemia (HP:0003075)2.15252634
47Renal cortical cysts (HP:0000803)2.14833402
48Abnormality of B cell number (HP:0010975)2.14297782
49Prominent supraorbital ridges (HP:0000336)2.13785200
50Brittle hair (HP:0002299)2.13719074
51Spinal muscular atrophy (HP:0007269)2.09963952
52Anhidrosis (HP:0000970)2.09540142
53Gait imbalance (HP:0002141)2.09205580
54Decreased central vision (HP:0007663)2.06896361
55Clumsiness (HP:0002312)2.03374475
56Pigmentary retinal degeneration (HP:0001146)2.02693994
57Absent eyebrow (HP:0002223)2.02091024
58Abnormality of the parathyroid morphology (HP:0011766)2.00347172
59Hemiparesis (HP:0001269)1.99712647
60Abnormality of alanine metabolism (HP:0010916)1.99668395
61Hyperalaninemia (HP:0003348)1.99668395
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99668395
63Thyroid-stimulating hormone excess (HP:0002925)1.95972173
64Prolonged bleeding time (HP:0003010)1.95944667
65Intestinal atresia (HP:0011100)1.95079223
66Broad-based gait (HP:0002136)1.92772569
67Hypomagnesemia (HP:0002917)1.92409630
68Abnormal drinking behavior (HP:0030082)1.91714406
69Polydipsia (HP:0001959)1.91714406
70Type II lissencephaly (HP:0007260)1.91462691
71Rhinitis (HP:0012384)1.91309978
72Disproportionate short-trunk short stature (HP:0003521)1.88874391
73Congenital hepatic fibrosis (HP:0002612)1.87730369
74Spontaneous abortion (HP:0005268)1.87586721
75B lymphocytopenia (HP:0010976)1.87549855
76Chronic bronchitis (HP:0004469)1.86965408
77Abnormality of the ileum (HP:0001549)1.85506598
78Gonadotropin excess (HP:0000837)1.85104195
79Astigmatism (HP:0000483)1.84947119
80Central scotoma (HP:0000603)1.84784754
81Bilateral sensorineural hearing impairment (HP:0008619)1.84250468
82Petechiae (HP:0000967)1.83262353
83Pancreatic islet-cell hyperplasia (HP:0004510)1.83044211
84Nephrogenic diabetes insipidus (HP:0009806)1.82578877
85Absent speech (HP:0001344)1.82347462
86Eosinophilia (HP:0001880)1.82241704
87Hypoplastic iliac wings (HP:0002866)1.82091073
88Meckel diverticulum (HP:0002245)1.81168672
89Premature skin wrinkling (HP:0100678)1.80451889
90Epistaxis (HP:0000421)1.77453915
91Abnormal respiratory motile cilium physiology (HP:0012261)1.75770391
92Enlarged kidneys (HP:0000105)1.75691684
93Sloping forehead (HP:0000340)1.75395619
94Abnormal ciliary motility (HP:0012262)1.75155220
95Tubular atrophy (HP:0000092)1.75041500
96Mesangial abnormality (HP:0001966)1.74074412
97Gonadal dysgenesis (HP:0000133)1.73908663
98Dandy-Walker malformation (HP:0001305)1.73767440
99Clubbing of toes (HP:0100760)1.73720364
100Occipital encephalocele (HP:0002085)1.72512752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.27122763
2FRK5.22913165
3NUAK13.82117109
4MST43.02331438
5ACVR1B2.77262601
6PINK12.28561542
7MUSK2.27507776
8BMPR1B2.23008094
9TXK2.22916351
10IRAK12.17146998
11ZAK2.15910877
12ADRBK22.15195172
13TLK12.07671097
14GRK11.98473690
15IRAK21.93408487
16TRIM281.87184363
17KIT1.81823064
18MAP2K71.76603542
19CDC71.67419853
20MYLK1.64706466
21PIK3CG1.49032506
22BCKDK1.45658458
23PDK21.40494661
24VRK11.35747631
25STK391.35221513
26PLK21.34711192
27TAOK31.34164333
28NLK1.25422200
29TEC1.25040254
30PLK41.19870894
31STK31.19119175
32AKT31.17326218
33ERBB41.15602843
34MAP4K21.15300444
35CSNK1G31.09899944
36TNK21.05945248
37CSNK1G11.05750757
38WNK41.04987963
39WNK31.03354351
40CSNK1A1L1.01135089
41OXSR10.96087693
42INSRR0.92912365
43BCR0.88883140
44CDK80.87214161
45GRK60.86264593
46CSNK1G20.86097258
47BTK0.84518893
48EPHA30.82451449
49CDK120.82014836
50OBSCN0.81966115
51ERBB30.81913864
52MARK30.78433973
53PTK2B0.74593920
54CASK0.72438101
55PAK30.72118738
56TGFBR10.61760008
57DAPK20.60372764
58BRSK20.59976954
59ADRBK10.57923097
60MKNK20.56886138
61FER0.54583474
62TNIK0.51508364
63PIK3CA0.49309290
64MAP3K40.49270287
65PRKCE0.49066835
66MAPK150.46313478
67FLT30.45341555
68SYK0.44541660
69JAK10.44009456
70MAPK130.42955431
71STK38L0.42944759
72PBK0.42928188
73CSNK1A10.42131669
74RPS6KA50.41828848
75EGFR0.41716483
76STK380.40839049
77MKNK10.39360205
78ITK0.39339500
79MINK10.38860749
80CSNK1D0.37787066
81RPS6KA40.37637044
82PRKCQ0.36631236
83NEK20.35791645
84MELK0.35351098
85STK160.32861097
86CDK30.32193792
87PRKAA10.31492408
88ROCK10.31330520
89KDR0.30732878
90CAMK2A0.29984956
91ERBB20.29916546
92PRKCG0.28001418
93DAPK10.27420846
94PRKAA20.24907504
95CHUK0.24485801
96SIK30.24327738
97IKBKB0.24125131
98WEE10.23343502
99ABL10.23171795
100ATM0.22638201

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003802.65401100
2Phototransduction_Homo sapiens_hsa047442.61637638
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53271207
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50875934
5Caffeine metabolism_Homo sapiens_hsa002322.30451105
6Chemical carcinogenesis_Homo sapiens_hsa052042.26984315
7Olfactory transduction_Homo sapiens_hsa047402.21845335
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17683941
9Butanoate metabolism_Homo sapiens_hsa006502.08633966
10Fanconi anemia pathway_Homo sapiens_hsa034602.07201534
11Basal transcription factors_Homo sapiens_hsa030222.04331957
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.01371385
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00406457
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98400992
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91468404
16Linoleic acid metabolism_Homo sapiens_hsa005911.88214635
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.84109740
18Fatty acid elongation_Homo sapiens_hsa000621.81180719
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79211473
20Nitrogen metabolism_Homo sapiens_hsa009101.76801632
21Propanoate metabolism_Homo sapiens_hsa006401.72760819
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71303239
23Nicotine addiction_Homo sapiens_hsa050331.69931982
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63209382
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60249850
26Salivary secretion_Homo sapiens_hsa049701.48861962
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45300538
28Non-homologous end-joining_Homo sapiens_hsa034501.43987174
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43266913
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39894631
31ABC transporters_Homo sapiens_hsa020101.39070797
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34877067
33Base excision repair_Homo sapiens_hsa034101.32743404
34Calcium signaling pathway_Homo sapiens_hsa040201.29052182
35Homologous recombination_Homo sapiens_hsa034401.26519973
36Arachidonic acid metabolism_Homo sapiens_hsa005901.26508848
37Peroxisome_Homo sapiens_hsa041461.26010268
38Platelet activation_Homo sapiens_hsa046111.25293657
39Steroid biosynthesis_Homo sapiens_hsa001001.21211944
40Retinol metabolism_Homo sapiens_hsa008301.17429659
41Circadian rhythm_Homo sapiens_hsa047101.17000115
42Taste transduction_Homo sapiens_hsa047421.16876590
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.16767976
44Lysine degradation_Homo sapiens_hsa003101.16250583
45Mismatch repair_Homo sapiens_hsa034301.15463765
46Circadian entrainment_Homo sapiens_hsa047131.14711724
47Ether lipid metabolism_Homo sapiens_hsa005651.11928413
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03026401
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97643895
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.94162503
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94147236
52beta-Alanine metabolism_Homo sapiens_hsa004100.93768562
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92235978
54One carbon pool by folate_Homo sapiens_hsa006700.89104852
55Regulation of autophagy_Homo sapiens_hsa041400.87147356
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.86747123
57Fatty acid degradation_Homo sapiens_hsa000710.84765840
58Ovarian steroidogenesis_Homo sapiens_hsa049130.84379476
59Purine metabolism_Homo sapiens_hsa002300.83231618
60Renin secretion_Homo sapiens_hsa049240.81595186
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.80765273
62Serotonergic synapse_Homo sapiens_hsa047260.76823111
63Glycerolipid metabolism_Homo sapiens_hsa005610.74897803
64Primary immunodeficiency_Homo sapiens_hsa053400.74872096
65Arginine and proline metabolism_Homo sapiens_hsa003300.74122238
66DNA replication_Homo sapiens_hsa030300.72903541
67Alcoholism_Homo sapiens_hsa050340.72404191
68Nucleotide excision repair_Homo sapiens_hsa034200.72330309
69RNA degradation_Homo sapiens_hsa030180.70369076
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70019164
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69591627
72Pyrimidine metabolism_Homo sapiens_hsa002400.68563373
73Fatty acid metabolism_Homo sapiens_hsa012120.67523531
74Fat digestion and absorption_Homo sapiens_hsa049750.65494233
75Long-term depression_Homo sapiens_hsa047300.64615813
76Glutathione metabolism_Homo sapiens_hsa004800.62450990
77Morphine addiction_Homo sapiens_hsa050320.61937270
78Systemic lupus erythematosus_Homo sapiens_hsa053220.61640816
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61541488
80Metabolic pathways_Homo sapiens_hsa011000.60449812
81Selenocompound metabolism_Homo sapiens_hsa004500.59202962
82GABAergic synapse_Homo sapiens_hsa047270.58875231
83Oocyte meiosis_Homo sapiens_hsa041140.57867815
84Mineral absorption_Homo sapiens_hsa049780.55934326
85Glutamatergic synapse_Homo sapiens_hsa047240.54122513
86Oxytocin signaling pathway_Homo sapiens_hsa049210.53256191
87PPAR signaling pathway_Homo sapiens_hsa033200.51771060
88Tyrosine metabolism_Homo sapiens_hsa003500.51602363
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50598450
90Vitamin digestion and absorption_Homo sapiens_hsa049770.47560019
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.47541802
92Insulin secretion_Homo sapiens_hsa049110.45971043
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40196083
94cAMP signaling pathway_Homo sapiens_hsa040240.36739700
95Dopaminergic synapse_Homo sapiens_hsa047280.35703673
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33112998
97Gap junction_Homo sapiens_hsa045400.32629111
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31776094
99ECM-receptor interaction_Homo sapiens_hsa045120.31656838
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.30651798

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