ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-serine transport (GO:0015825)	4.90648507
2	Golgi transport vesicle coating (GO:0048200)	4.57382721
3	COPI coating of Golgi vesicle (GO:0048205)	4.57382721
4	serine transport (GO:0032329)	4.09138630
5	mitochondrial calcium ion transport (GO:0006851)	3.95009708
6	rRNA methylation (GO:0031167)	3.68132114
7	protein maturation by protein folding (GO:0022417)	3.64631411
8	protein neddylation (GO:0045116)	3.58931658
9	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.55564936
10	rRNA modification (GO:0000154)	3.42934617
11	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.42486217
12	UMP metabolic process (GO:0046049)	3.42486217
13	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.42486217
14	UMP biosynthetic process (GO:0006222)	3.42486217
15	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.39292315
16	nucleobase biosynthetic process (GO:0046112)	3.37372772
17	proline biosynthetic process (GO:0006561)	3.36779628
18	tRNA aminoacylation for protein translation (GO:0006418)	3.33031863
19	lipopolysaccharide biosynthetic process (GO:0009103)	3.26013142
20	amino acid activation (GO:0043038)	3.23105777
21	tRNA aminoacylation (GO:0043039)	3.23105777
22	NADPH regeneration (GO:0006740)	3.21392013
23	leukotriene biosynthetic process (GO:0019370)	3.20350443
24	adenine nucleotide transport (GO:0051503)	3.15080674
25	stress fiber assembly (GO:0043149)	3.11327136
26	cysteine metabolic process (GO:0006534)	3.10656527
27	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.10231623
28	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.08150641
29	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.07378832
30	proteasome assembly (GO:0043248)	3.06319873
31	pentose-phosphate shunt (GO:0006098)	3.04878463
32	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.00416239
33	purine ribonucleotide transport (GO:0015868)	2.99053305
34	platelet aggregation (GO:0070527)	2.98081770
35	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.96745481
36	glutathione metabolic process (GO:0006749)	2.96206667
37	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.91372352
38	regulation of penile erection (GO:0060405)	2.91349203
39	mitotic cytokinesis (GO:0000281)	2.86881139
40	negative regulation by host of viral transcription (GO:0043922)	2.86667026
41	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.85288291
42	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.83678832
43	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.81103263
44	DNA unwinding involved in DNA replication (GO:0006268)	2.79430781
45	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.77118496
46	mitochondrial DNA metabolic process (GO:0032042)	2.77020448
47	UV protection (GO:0009650)	2.76691132
48	purine nucleobase biosynthetic process (GO:0009113)	2.76520923
49	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.75854565
50	formation of translation preinitiation complex (GO:0001731)	2.73691848
51	actin nucleation (GO:0045010)	2.71771073
52	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.71294043
53	regulation of integrin-mediated signaling pathway (GO:2001044)	2.71278404
54	cell wall macromolecule catabolic process (GO:0016998)	2.71023355
55	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.70847624
56	DNA damage response, detection of DNA damage (GO:0042769)	2.70383745
57	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.66891743
58	short-term memory (GO:0007614)	2.65963235
59	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.65339188
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65232420
61	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.62535240
62	sulfur amino acid biosynthetic process (GO:0000097)	2.62409657
63	DNA strand elongation (GO:0022616)	2.61501037
64	lipopolysaccharide metabolic process (GO:0008653)	2.61190650
65	DNA strand elongation involved in DNA replication (GO:0006271)	2.59749031
66	muscle cell migration (GO:0014812)	2.58301909
67	cullin deneddylation (GO:0010388)	2.56353834
68	CTP metabolic process (GO:0046036)	2.54995702
69	CTP biosynthetic process (GO:0006241)	2.54995702
70	regulation of mitochondrial translation (GO:0070129)	2.54481941
71	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52379583
72	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.52348283
73	DNA excision (GO:0044349)	2.52348283
74	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.52245619
75	cytoskeleton-dependent cytokinesis (GO:0061640)	2.51135854
76	actin filament depolymerization (GO:0030042)	2.50561884
77	transcription from mitochondrial promoter (GO:0006390)	2.49759410
78	outer ear morphogenesis (GO:0042473)	2.49368002
79	cellular response to vitamin D (GO:0071305)	2.48746327
80	UTP biosynthetic process (GO:0006228)	2.48596515
81	alanine transport (GO:0032328)	2.48457632
82	glucose catabolic process (GO:0006007)	2.48143477
83	regulation of immune response to tumor cell (GO:0002837)	2.48064822
84	regulation of response to tumor cell (GO:0002834)	2.48064822
85	positive regulation of response to tumor cell (GO:0002836)	2.48064822
86	positive regulation of immune response to tumor cell (GO:0002839)	2.48064822
87	UTP metabolic process (GO:0046051)	2.47606981
88	adenosine receptor signaling pathway (GO:0001973)	2.46012769
89	icosanoid biosynthetic process (GO:0046456)	2.44341612
90	fatty acid derivative biosynthetic process (GO:1901570)	2.44341612
91	regulation of translational termination (GO:0006449)	2.42759482
92	cellular response to vitamin (GO:0071295)	2.42602363
93	telomere maintenance via semi-conservative replication (GO:0032201)	2.42388856
94	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.42236245
95	peptidyl-arginine omega-N-methylation (GO:0035247)	2.39653679
96	protein hydroxylation (GO:0018126)	2.38896768
97	negative regulation of JAK-STAT cascade (GO:0046426)	2.38594501
98	nucleobase-containing small molecule interconversion (GO:0015949)	2.38116088
99	bone trabecula formation (GO:0060346)	2.38030538
100	negative regulation of ligase activity (GO:0051352)	2.37158367

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.37361468
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.90539936
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.17357788
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.16340355
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12277112
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.60322641
7	XRN2_22483619_ChIP-Seq_HELA_Human	2.58907516
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.57522739
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.54186727
10	DCP1A_22483619_ChIP-Seq_HELA_Human	2.53947917
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.38533046
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.30370911
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.22873025
14	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.18454827
15	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.17981762
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.15948418
17	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.09722950
18	GABP_19822575_ChIP-Seq_HepG2_Human	2.06090871
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02692459
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.02349392
21	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.01830995
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.98891379
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98038731
24	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.94519330
25	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.93492646
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92839596
27	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.85154559
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84155445
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82137755
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.77942699
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75122913
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70713803
33	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.66259353
34	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.63457523
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62586365
36	TFEB_21752829_ChIP-Seq_HELA_Human	1.58979825
37	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.56881571
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.56426674
39	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.56152424
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.55011481
41	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.54477525
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53654831
43	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.50364990
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.48201251
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.46021908
46	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45920407
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43468895
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.43231991
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42291597
50	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.40109798
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40017790
52	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.39853553
53	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.38446654
54	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.36239617
55	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.36108629
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36021703
57	P68_20966046_ChIP-Seq_HELA_Human	1.35847832
58	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.33444537
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32480177
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.32372180
61	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.30491686
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.30230399
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27019552
64	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25862528
65	VDR_21846776_ChIP-Seq_THP-1_Human	1.25582635
66	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.22722175
67	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.20287929
68	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19513517
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.17956810
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.15789439
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12842559
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08881260
73	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.07121618
74	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.06602067
75	ZNF263_19887448_ChIP-Seq_K562_Human	1.05307589
76	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.05028757
77	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04411162
78	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.04207914
79	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.03352908
80	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.03242071
81	LXR_22292898_ChIP-Seq_THP-1_Human	1.02695050
82	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.02573129
83	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.02538072
84	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.02219079
85	TP53_22127205_ChIP-Seq_IMR90_Human	1.01596208
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00751946
87	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00349810
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.00118834
89	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.98904559
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98316484
91	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.97370764
92	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.97081540
93	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.96487402
94	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95869175
95	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.95279120
96	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.95043755
97	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94631660
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92889429
99	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.92415202
100	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.92255909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	3.80626767
2	MP0010030_abnormal_orbit_morphology	3.71729380
3	MP0003111_abnormal_nucleus_morphology	2.95873720
4	MP0005464_abnormal_platelet_physiology	2.84126213
5	MP0002877_abnormal_melanocyte_morpholog	2.78207012
6	MP0003566_abnormal_cell_adhesion	2.77099348
7	MP0005171_absent_coat_pigmentation	2.62158327
8	MP0005623_abnormal_meninges_morphology	2.42332591
9	MP0004272_abnormal_basement_membrane	2.39479531
10	MP0003705_abnormal_hypodermis_morpholog	2.38537296
11	MP0008260_abnormal_autophagy	2.25317992
12	MP0005257_abnormal_intraocular_pressure	2.24695120
13	MP0002653_abnormal_ependyma_morphology	2.19627563
14	MP0008932_abnormal_embryonic_tissue	2.03412421
15	MP0003136_yellow_coat_color	2.01828133
16	MP0005058_abnormal_lysosome_morphology	2.00068715
17	MP0010094_abnormal_chromosome_stability	1.92613204
18	MP0000858_altered_metastatic_potential	1.89486469
19	MP0003279_aneurysm	1.82670229
20	MP0001958_emphysema	1.69880802
21	MP0010368_abnormal_lymphatic_system	1.65282143
22	MP0000428_abnormal_craniofacial_morphol	1.63428625
23	MP0001542_abnormal_bone_strength	1.58803055
24	MP0001661_extended_life_span	1.58687550
25	MP0005503_abnormal_tendon_morphology	1.57623203
26	MP0008789_abnormal_olfactory_epithelium	1.55657949
27	MP0008007_abnormal_cellular_replicative	1.53171877
28	MP0006054_spinal_hemorrhage	1.51911865
29	MP0000049_abnormal_middle_ear	1.50984783
30	MP0000358_abnormal_cell_content/	1.50823027
31	MP0005508_abnormal_skeleton_morphology	1.49794156
32	MP0002089_abnormal_postnatal_growth/wei	1.48068669
33	MP0001849_ear_inflammation	1.48056680
34	MP0001299_abnormal_eye_distance/	1.45912584
35	MP0002938_white_spotting	1.45779039
36	MP0004957_abnormal_blastocyst_morpholog	1.42814794
37	MP0001730_embryonic_growth_arrest	1.39444868
38	MP0004147_increased_porphyrin_level	1.38805658
39	MP0003942_abnormal_urinary_system	1.38318291
40	MP0002234_abnormal_pharynx_morphology	1.34554333
41	MP0001293_anophthalmia	1.32871726
42	MP0005023_abnormal_wound_healing	1.24495510
43	MP0002736_abnormal_nociception_after	1.20585462
44	MP0006035_abnormal_mitochondrial_morpho	1.19411908
45	MP0008058_abnormal_DNA_repair	1.14491603
46	MP0006036_abnormal_mitochondrial_physio	1.13604650
47	MP0002084_abnormal_developmental_patter	1.08938136
48	MP0005197_abnormal_uvea_morphology	1.07098135
49	MP0005501_abnormal_skin_physiology	1.06737690
50	MP0002080_prenatal_lethality	1.06413258
51	MP0009697_abnormal_copulation	1.05740930
52	MP0009384_cardiac_valve_regurgitation	1.05736275
53	MP0003091_abnormal_cell_migration	1.04997298
54	MP0003786_premature_aging	1.04849481
55	MP0005174_abnormal_tail_pigmentation	1.03898091
56	MP0000013_abnormal_adipose_tissue	1.03301267
57	MP0000534_abnormal_ureter_morphology	1.03106226
58	MP0004185_abnormal_adipocyte_glucose	1.02783465
59	MP0000767_abnormal_smooth_muscle	1.02334103
60	MP0005084_abnormal_gallbladder_morpholo	1.01946349
61	MP0005248_abnormal_Harderian_gland	1.01647045
62	MP0009250_abnormal_appendicular_skeleto	1.00097658
63	MP0002085_abnormal_embryonic_tissue	0.99648847
64	MP0000350_abnormal_cell_proliferation	0.99409136
65	MP0009780_abnormal_chondrocyte_physiolo	0.98465211
66	MP0002896_abnormal_bone_mineralization	0.98022793
67	MP0002177_abnormal_outer_ear	0.96952012
68	MP0001672_abnormal_embryogenesis/_devel	0.96158016
69	MP0005380_embryogenesis_phenotype	0.96158016
70	MP0003077_abnormal_cell_cycle	0.93981411
71	MP0001879_abnormal_lymphatic_vessel	0.91985079
72	MP0003448_altered_tumor_morphology	0.91197668
73	MP0001286_abnormal_eye_development	0.90933676
74	MP0003283_abnormal_digestive_organ	0.90088561
75	MP0003984_embryonic_growth_retardation	0.90060094
76	MP0000163_abnormal_cartilage_morphology	0.86869228
77	MP0002092_abnormal_eye_morphology	0.86460946
78	MP0002086_abnormal_extraembryonic_tissu	0.86358843
79	MP0001697_abnormal_embryo_size	0.86342919
80	MP0003755_abnormal_palate_morphology	0.86318882
81	MP0003693_abnormal_embryo_hatching	0.86165669
82	MP0009053_abnormal_anal_canal	0.84613264
83	MP0000432_abnormal_head_morphology	0.84355534
84	MP0002088_abnormal_embryonic_growth/wei	0.82684590
85	MP0003385_abnormal_body_wall	0.82340458
86	MP0005330_cardiomyopathy	0.81732809
87	MP0000749_muscle_degeneration	0.81556638
88	MP0000750_abnormal_muscle_regeneration	0.79810493
89	MP0006292_abnormal_olfactory_placode	0.79548908
90	MP0001243_abnormal_dermal_layer	0.78352909
91	MP0000613_abnormal_salivary_gland	0.78220904
92	MP0001915_intracranial_hemorrhage	0.77559543
93	MP0001270_distended_abdomen	0.77312572
94	MP0005410_abnormal_fertilization	0.77237505
95	MP0002060_abnormal_skin_morphology	0.77196300
96	MP0003567_abnormal_fetal_cardiomyocyte	0.75152678
97	MP0010307_abnormal_tumor_latency	0.74734732
98	MP0003941_abnormal_skin_development	0.74477528
99	MP0005384_cellular_phenotype	0.74214607
100	MP0000759_abnormal_skeletal_muscle	0.73655673

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	5.63732439
2	Protrusio acetabuli (HP:0003179)	4.41869691
3	Abnormality of dentin (HP:0010299)	4.15231252
4	Bilateral sensorineural hearing impairment (HP:0008619)	4.06774342
5	Microvesicular hepatic steatosis (HP:0001414)	3.89330815
6	Hypophosphatemic rickets (HP:0004912)	3.47102723
7	Increased mean platelet volume (HP:0011877)	3.33346947
8	Menorrhagia (HP:0000132)	3.23888820
9	Entropion (HP:0000621)	2.90035380
10	Abnormal platelet volume (HP:0011876)	2.81820126
11	Vertebral compression fractures (HP:0002953)	2.77435242
12	Trigonocephaly (HP:0000243)	2.73679657
13	Thin bony cortex (HP:0002753)	2.70770552
14	Ankle contracture (HP:0006466)	2.68713069
15	Abnormality of cochlea (HP:0000375)	2.63708873
16	Nonimmune hydrops fetalis (HP:0001790)	2.54582321
17	Breast hypoplasia (HP:0003187)	2.49006243
18	Slender build (HP:0001533)	2.48066166
19	Short nail (HP:0001799)	2.45221264
20	Hypokinesia (HP:0002375)	2.45175506
21	Tinnitus (HP:0000360)	2.43962742
22	Broad metatarsal (HP:0001783)	2.43618374
23	Rectal fistula (HP:0100590)	2.42848691
24	Rectovaginal fistula (HP:0000143)	2.42848691
25	Spinal rigidity (HP:0003306)	2.41982914
26	Degeneration of anterior horn cells (HP:0002398)	2.41216299
27	Abnormality of the anterior horn cell (HP:0006802)	2.41216299
28	Abnormality of oral frenula (HP:0000190)	2.40567889
29	Vaginal fistula (HP:0004320)	2.35622795
30	Ulnar bowing (HP:0003031)	2.34358625
31	Rough bone trabeculation (HP:0100670)	2.31253229
32	Septate vagina (HP:0001153)	2.30346224
33	Genu recurvatum (HP:0002816)	2.29474366
34	Morphological abnormality of the inner ear (HP:0011390)	2.27793393
35	Dilatation of the ascending aorta (HP:0005111)	2.27076893
36	Insomnia (HP:0100785)	2.26015905
37	Abnormal delivery (HP:0001787)	2.19270830
38	Intestinal fistula (HP:0100819)	2.19259122
39	Facial hemangioma (HP:0000329)	2.16785329
40	Flat occiput (HP:0005469)	2.15416328
41	Poikiloderma (HP:0001029)	2.15160084
42	Abnormality of the costochondral junction (HP:0000919)	2.14652244
43	Abnormality of the umbilical cord (HP:0010881)	2.12705749
44	Prolonged bleeding time (HP:0003010)	2.07135201
45	Natal tooth (HP:0000695)	2.03694503
46	Tibial bowing (HP:0002982)	2.03641246
47	Abnormal trabecular bone morphology (HP:0100671)	2.03584890
48	Abnormality of the tricuspid valve (HP:0001702)	2.03576573
49	Mesomelia (HP:0003027)	2.02989274
50	Coronal craniosynostosis (HP:0004440)	2.02132030
51	Generalized amyotrophy (HP:0003700)	2.01654024
52	Wormian bones (HP:0002645)	2.01270509
53	Generalized aminoaciduria (HP:0002909)	2.01140028
54	Prolonged neonatal jaundice (HP:0006579)	2.00891010
55	Reticulocytosis (HP:0001923)	1.99123675
56	J-shaped sella turcica (HP:0002680)	1.96835111
57	Abnormality of abdominal situs (HP:0011620)	1.96105558
58	Abdominal situs inversus (HP:0003363)	1.96105558
59	Bladder diverticulum (HP:0000015)	1.94045617
60	Abnormality of the diencephalon (HP:0010662)	1.93478514
61	Elbow flexion contracture (HP:0002987)	1.92428186
62	Aortic dissection (HP:0002647)	1.91632252
63	Male infertility (HP:0003251)	1.91582242
64	Aortic aneurysm (HP:0004942)	1.86074119
65	Impaired platelet aggregation (HP:0003540)	1.85992669
66	Abnormal platelet function (HP:0011869)	1.85992669
67	Joint stiffness (HP:0001387)	1.85627375
68	Hyperacusis (HP:0010780)	1.83804463
69	Shallow orbits (HP:0000586)	1.82773910
70	Venous insufficiency (HP:0005293)	1.82174294
71	Blue sclerae (HP:0000592)	1.81466641
72	Neonatal short-limb short stature (HP:0008921)	1.80443875
73	Long toe (HP:0010511)	1.79009159
74	Bowed forearm bones (HP:0003956)	1.78960239
75	Bowing of the arm (HP:0006488)	1.78960239
76	Petechiae (HP:0000967)	1.78721592
77	Aplastic anemia (HP:0001915)	1.78625123
78	Tongue fasciculations (HP:0001308)	1.78519477
79	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.78178329
80	Femoral bowing (HP:0002980)	1.77343276
81	Abnormal large intestine physiology (HP:0012700)	1.74670493
82	Turricephaly (HP:0000262)	1.73708589
83	Epistaxis (HP:0000421)	1.71559458
84	Cutaneous melanoma (HP:0012056)	1.67503107
85	Capillary hemangiomas (HP:0005306)	1.67324253
86	Breech presentation (HP:0001623)	1.66464649
87	Venous abnormality (HP:0002624)	1.65698711
88	Truncus arteriosus (HP:0001660)	1.65404868
89	Abnormal number of erythroid precursors (HP:0012131)	1.65078330
90	Renal duplication (HP:0000075)	1.64154286
91	Bowel diverticulosis (HP:0005222)	1.64086886
92	Aortic regurgitation (HP:0001659)	1.63682666
93	Hyperlipoproteinemia (HP:0010980)	1.62836826
94	Squamous cell carcinoma (HP:0002860)	1.62281961
95	Mitral regurgitation (HP:0001653)	1.61554571
96	Type 1 muscle fiber predominance (HP:0003803)	1.61118627
97	Upper limb amyotrophy (HP:0009129)	1.61018276
98	Distal upper limb amyotrophy (HP:0007149)	1.61018276
99	Abnormality of the distal phalanges of the toes (HP:0010182)	1.60515844
100	Coxa vara (HP:0002812)	1.58782681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	3.88437099
2	TESK2	3.65091858
3	PRKD3	3.57543116
4	CAMKK2	3.36313220
5	BUB1	3.34908410
6	CAMK1D	3.26686183
7	EIF2AK1	3.16756102
8	TESK1	3.04679809
9	NME2	2.60585297
10	NEK9	2.41597833
11	MYLK	2.14952256
12	PAK4	1.98874733
13	CAMK1G	1.97774396
14	IRAK3	1.94018717
15	BMX	1.89787744
16	SCYL2	1.69516268
17	EPHA3	1.69444353
18	MET	1.57932687
19	KDR	1.55205945
20	SIK1	1.55194015
21	NEK1	1.54166787
22	ERBB4	1.52043730
23	EPHB1	1.45423758
24	TTN	1.44862227
25	EPHA2	1.40405658
26	FLT3	1.39886972
27	EPHB2	1.32794011
28	PDGFRA	1.27350037
29	EIF2AK3	1.24668491
30	ILK	1.24643230
31	BCKDK	1.23782351
32	PAK1	1.21735759
33	MST4	1.21144501
34	PAK2	1.21105357
35	KSR2	1.20520521
36	MST1R	1.18186096
37	PTK2	1.15439294
38	NTRK1	1.13311554
39	PBK	1.10353359
40	MOS	1.10039221
41	PLK2	1.08201113
42	TSSK6	1.00443688
43	CAMKK1	0.98862738
44	TRIM28	0.97582131
45	PIM2	0.96761938
46	CDK8	0.96073161
47	PIK3CG	0.93685824
48	STK16	0.87771386
49	PRKD2	0.87538215
50	PLK3	0.86728499
51	AURKA	0.83963680
52	RAF1	0.83227000
53	VRK1	0.78314442
54	VRK2	0.75110798
55	BMPR1B	0.73811075
56	WNK3	0.73616229
57	RPS6KA4	0.67608701
58	DYRK1B	0.67377984
59	CDK12	0.66589260
60	GRK6	0.66016065
61	GRK5	0.65284552
62	CDK3	0.63135445
63	LMTK2	0.62675128
64	ICK	0.61334363
65	WEE1	0.60953619
66	MKNK1	0.60825246
67	AURKB	0.59276718
68	ATR	0.55821888
69	MAP2K3	0.54468843
70	PKN2	0.54000706
71	ARAF	0.53744854
72	TAOK1	0.53391292
73	PLK1	0.52620115
74	ERBB3	0.52552065
75	PTK2B	0.49510783
76	TRIB3	0.48519051
77	CSNK1G3	0.48356573
78	CDK14	0.46782215
79	TGFBR1	0.46117157
80	BTK	0.45469435
81	EEF2K	0.42805260
82	ROCK1	0.42528299
83	CSF1R	0.41358443
84	CDK7	0.41126003
85	MAP2K1	0.41007542
86	MAP3K5	0.40645779
87	CSNK1G1	0.38882712
88	LRRK2	0.37296817
89	DAPK1	0.37058670
90	TEC	0.36500365
91	IRAK2	0.35787872
92	CHEK1	0.32695007
93	CCNB1	0.32402982
94	ROCK2	0.31949342
95	PAK6	0.31215062
96	SRC	0.30485885
97	PRKD1	0.30438883
98	TAOK2	0.29070333
99	SIK3	0.27865631
100	CDK15	0.27203479

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.98137007
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.16397497
3	DNA replication_Homo sapiens_hsa03030	2.85048019
4	Proteasome_Homo sapiens_hsa03050	2.45100245
5	Sulfur relay system_Homo sapiens_hsa04122	2.41662788
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.36644655
7	Mismatch repair_Homo sapiens_hsa03430	2.33841222
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.33162876
9	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.27187862
10	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.00126204
11	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.86953856
12	One carbon pool by folate_Homo sapiens_hsa00670	1.81922244
13	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.80989514
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.78096930
15	Glutathione metabolism_Homo sapiens_hsa00480	1.72115149
16	Base excision repair_Homo sapiens_hsa03410	1.69753872
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.69211189
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.67832102
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.66645470
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.65889378
21	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.64516988
22	ECM-receptor interaction_Homo sapiens_hsa04512	1.62316320
23	Fatty acid elongation_Homo sapiens_hsa00062	1.60983287
24	Cell cycle_Homo sapiens_hsa04110	1.55478374
25	Shigellosis_Homo sapiens_hsa05131	1.52271835
26	Vibrio cholerae infection_Homo sapiens_hsa05110	1.48992599
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48143002
28	Pentose phosphate pathway_Homo sapiens_hsa00030	1.46413132
29	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.44893611
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.43689802
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.33497604
32	Spliceosome_Homo sapiens_hsa03040	1.27961280
33	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.26921278
34	RNA transport_Homo sapiens_hsa03013	1.24239181
35	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.22180265
36	RNA polymerase_Homo sapiens_hsa03020	1.21495906
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18590429
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16256533
39	Platelet activation_Homo sapiens_hsa04611	1.16178020
40	Galactose metabolism_Homo sapiens_hsa00052	1.13546664
41	Basal transcription factors_Homo sapiens_hsa03022	1.11376917
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.07567244
43	Protein export_Homo sapiens_hsa03060	1.07154200
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.05086344
45	Carbon metabolism_Homo sapiens_hsa01200	1.03924449
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.03419241
47	Bladder cancer_Homo sapiens_hsa05219	0.99008883
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98900159
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.98252511
50	Focal adhesion_Homo sapiens_hsa04510	0.97977362
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.96892250
52	Purine metabolism_Homo sapiens_hsa00230	0.93057283
53	Homologous recombination_Homo sapiens_hsa03440	0.88862953
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.88236198
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85531456
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.85473606
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.85452025
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83633146
59	Malaria_Homo sapiens_hsa05144	0.76240702
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.75123882
61	Proteoglycans in cancer_Homo sapiens_hsa05205	0.75117928
62	Thyroid cancer_Homo sapiens_hsa05216	0.72382215
63	Melanoma_Homo sapiens_hsa05218	0.72098356
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.62839815
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62821413
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.61879533
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61412085
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.61102825
69	Gap junction_Homo sapiens_hsa04540	0.60085130
70	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.58995373
71	Salmonella infection_Homo sapiens_hsa05132	0.56841877
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56502162
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54352522
74	Lysosome_Homo sapiens_hsa04142	0.53837962
75	Adherens junction_Homo sapiens_hsa04520	0.53083845
76	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.52854493
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51712838
78	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50024165
79	p53 signaling pathway_Homo sapiens_hsa04115	0.48309318
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45078326
81	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.44462347
82	Sulfur metabolism_Homo sapiens_hsa00920	0.39985341
83	MicroRNAs in cancer_Homo sapiens_hsa05206	0.38254933
84	Endocytosis_Homo sapiens_hsa04144	0.38178880
85	Pancreatic cancer_Homo sapiens_hsa05212	0.36662434
86	Small cell lung cancer_Homo sapiens_hsa05222	0.35320989
87	Axon guidance_Homo sapiens_hsa04360	0.35236538
88	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.34541804
89	Metabolic pathways_Homo sapiens_hsa01100	0.33061043
90	Apoptosis_Homo sapiens_hsa04210	0.32463077
91	Huntingtons disease_Homo sapiens_hsa05016	0.31108112
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30370839
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27716520
94	Oocyte meiosis_Homo sapiens_hsa04114	0.27325397
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.24076774
96	Melanogenesis_Homo sapiens_hsa04916	0.23255948
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.22403907
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21600225
99	Butanoate metabolism_Homo sapiens_hsa00650	0.21012819
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20158893

ALG1L6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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