ALG1L9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.55180634
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.76158381
3ATP synthesis coupled proton transport (GO:0015986)5.48633611
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.48633611
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.46114341
6kinetochore assembly (GO:0051382)4.93069522
7kinetochore organization (GO:0051383)4.83616906
8regulation of mitochondrial translation (GO:0070129)4.81172935
9viral transcription (GO:0019083)4.78050125
10translational termination (GO:0006415)4.59100215
11ribosomal small subunit biogenesis (GO:0042274)4.45093471
12rRNA modification (GO:0000154)4.44801374
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34245810
14cotranslational protein targeting to membrane (GO:0006613)4.32050426
15protein targeting to ER (GO:0045047)4.28721362
16protein complex biogenesis (GO:0070271)4.27712254
17ribosomal small subunit assembly (GO:0000028)4.21533964
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.11342061
19peptidyl-histidine modification (GO:0018202)4.10285811
20chromatin remodeling at centromere (GO:0031055)4.09537272
21protein localization to endoplasmic reticulum (GO:0070972)4.09206279
22mitochondrial respiratory chain complex assembly (GO:0033108)4.01513477
23pseudouridine synthesis (GO:0001522)3.94728768
24base-excision repair, AP site formation (GO:0006285)3.93529013
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89888863
26translational elongation (GO:0006414)3.86736874
27proteasome assembly (GO:0043248)3.84671099
28inner mitochondrial membrane organization (GO:0007007)3.81038256
29GMP metabolic process (GO:0046037)3.79129258
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77899083
31CENP-A containing nucleosome assembly (GO:0034080)3.77406076
32ribosomal large subunit biogenesis (GO:0042273)3.72433900
33maturation of SSU-rRNA (GO:0030490)3.65433318
34respiratory electron transport chain (GO:0022904)3.63124145
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.62221671
36NADH dehydrogenase complex assembly (GO:0010257)3.62221671
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62221671
38electron transport chain (GO:0022900)3.60782388
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.60148517
40termination of RNA polymerase III transcription (GO:0006386)3.60148517
41viral life cycle (GO:0019058)3.59812117
42cell wall macromolecule catabolic process (GO:0016998)3.57802212
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56678852
44translational initiation (GO:0006413)3.55376903
45purine nucleobase biosynthetic process (GO:0009113)3.54901022
46resolution of meiotic recombination intermediates (GO:0000712)3.53963119
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51348807
48cellular component biogenesis (GO:0044085)3.42138239
49cellular protein complex disassembly (GO:0043624)3.41550062
50pyrimidine nucleotide catabolic process (GO:0006244)3.41099341
51nucleobase biosynthetic process (GO:0046112)3.38791337
52negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.32936419
53intracellular protein transmembrane import (GO:0044743)3.30862332
54cytochrome complex assembly (GO:0017004)3.28489898
55ribonucleoprotein complex biogenesis (GO:0022613)3.28172142
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27300695
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27300695
58metaphase plate congression (GO:0051310)3.24116266
59DNA strand elongation involved in DNA replication (GO:0006271)3.19818871
60translation (GO:0006412)3.19098761
61mitochondrion morphogenesis (GO:0070584)3.18426914
62rRNA methylation (GO:0031167)3.18223956
63establishment of integrated proviral latency (GO:0075713)3.16402425
64water-soluble vitamin biosynthetic process (GO:0042364)3.13297028
65protein targeting to mitochondrion (GO:0006626)3.12010472
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11034236
67DNA strand elongation (GO:0022616)3.08007066
68lysine catabolic process (GO:0006554)3.07094358
69lysine metabolic process (GO:0006553)3.07094358
70IMP biosynthetic process (GO:0006188)3.06921331
71protein neddylation (GO:0045116)3.06399897
72spliceosomal snRNP assembly (GO:0000387)3.04062174
73heterochromatin organization (GO:0070828)3.02825907
74respiratory chain complex IV assembly (GO:0008535)3.01257715
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01248522
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00603378
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00029913
78histone exchange (GO:0043486)2.97428647
79DNA replication-independent nucleosome assembly (GO:0006336)2.97333764
80DNA replication-independent nucleosome organization (GO:0034724)2.97333764
81rRNA processing (GO:0006364)2.96970330
82telomere maintenance via semi-conservative replication (GO:0032201)2.96737038
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95296782
84mannosylation (GO:0097502)2.94209338
85rRNA metabolic process (GO:0016072)2.92247092
86protein complex disassembly (GO:0043241)2.92053357
87cell wall macromolecule metabolic process (GO:0044036)2.90283774
88protein targeting to membrane (GO:0006612)2.90281072
89negative regulation of telomerase activity (GO:0051974)2.90138589
90establishment of protein localization to mitochondrion (GO:0072655)2.89883686
91transcription-coupled nucleotide-excision repair (GO:0006283)2.89859608
92cellular ketone body metabolic process (GO:0046950)2.86588086
93DNA replication checkpoint (GO:0000076)2.86400418
94ATP biosynthetic process (GO:0006754)2.86134418
95protein polyglutamylation (GO:0018095)2.85008908
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.83907847
97negative regulation of ligase activity (GO:0051352)2.82132016
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82132016
99macromolecular complex disassembly (GO:0032984)2.79522982
100lateral sprouting from an epithelium (GO:0060601)2.79122980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.22283880
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.60452450
3E2F7_22180533_ChIP-Seq_HELA_Human4.49954176
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12672460
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.65055658
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.60964993
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18233156
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.07765156
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02233266
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98096490
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98068846
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.97002917
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79890656
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79633421
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74409673
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71946888
17ELK1_19687146_ChIP-ChIP_HELA_Human2.61255897
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57950173
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48872902
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37010235
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35142976
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32087943
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26351865
24MYC_18940864_ChIP-ChIP_HL60_Human2.25991005
25FOXP3_21729870_ChIP-Seq_TREG_Human2.24931864
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23322302
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22312594
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21335261
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15383293
30VDR_23849224_ChIP-Seq_CD4+_Human2.06285299
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03048875
32XRN2_22483619_ChIP-Seq_HELA_Human1.99183405
33TTF2_22483619_ChIP-Seq_HELA_Human1.98336668
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.97236150
35VDR_22108803_ChIP-Seq_LS180_Human1.94244649
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84777687
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.82395605
38GABP_19822575_ChIP-Seq_HepG2_Human1.82385228
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79805410
40DCP1A_22483619_ChIP-Seq_HELA_Human1.79600869
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78388678
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73227030
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.64627391
44AR_21909140_ChIP-Seq_LNCAP_Human1.60929998
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59228203
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57193847
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52589101
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50990948
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.50479718
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48083156
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45620532
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42227433
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35803819
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.32581276
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.32341434
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31784092
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27988244
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27289394
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25171047
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24057410
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.22810728
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22203210
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20426193
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17992749
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16602455
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15917547
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15009309
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14648490
69IRF1_19129219_ChIP-ChIP_H3396_Human1.13337116
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10897005
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09928381
72FUS_26573619_Chip-Seq_HEK293_Human1.09413376
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06313781
74KDM5A_27292631_Chip-Seq_BREAST_Human1.06042091
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05868152
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.02480534
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02041626
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00659054
79EWS_26573619_Chip-Seq_HEK293_Human0.99544039
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96580748
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.96435460
82ZNF274_21170338_ChIP-Seq_K562_Hela0.95463093
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.93580898
84CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88817145
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.85907920
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.84050077
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83707975
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83189009
89ELF5_23300383_ChIP-Seq_T47D_Human0.80642513
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79861117
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78322578
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74735620
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73443911
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72025642
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70539412
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.70075407
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69001235
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68640137
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68011298
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67372448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology6.00227936
2MP0006292_abnormal_olfactory_placode5.29972735
3MP0001346_abnormal_lacrimal_gland3.52734508
4MP0009379_abnormal_foot_pigmentation3.18918743
5MP0000566_synostosis3.10328021
6MP0001293_anophthalmia2.96672196
7MP0008789_abnormal_olfactory_epithelium2.85600058
8MP0002938_white_spotting2.65992487
9MP0002638_abnormal_pupillary_reflex2.35620795
10MP0005248_abnormal_Harderian_gland2.34237077
11MP0003718_maternal_effect2.22024267
12MP0002837_dystrophic_cardiac_calcinosis2.15890845
13MP0001905_abnormal_dopamine_level2.04818735
14MP0003693_abnormal_embryo_hatching1.88252156
15MP0003941_abnormal_skin_development1.83367869
16MP0002653_abnormal_ependyma_morphology1.79357340
17MP0000579_abnormal_nail_morphology1.71902148
18MP0008058_abnormal_DNA_repair1.71343645
19MP0005394_taste/olfaction_phenotype1.69207051
20MP0005499_abnormal_olfactory_system1.69207051
21MP0010094_abnormal_chromosome_stability1.61924374
22MP0002736_abnormal_nociception_after1.61374311
23MP0004957_abnormal_blastocyst_morpholog1.61327052
24MP0001984_abnormal_olfaction1.57267029
25MP0002697_abnormal_eye_size1.56767239
26MP0003111_abnormal_nucleus_morphology1.52782864
27MP0005391_vision/eye_phenotype1.46103573
28MP0002102_abnormal_ear_morphology1.42594467
29MP0002234_abnormal_pharynx_morphology1.41849783
30MP0008877_abnormal_DNA_methylation1.39606880
31MP0002092_abnormal_eye_morphology1.39533542
32MP0005171_absent_coat_pigmentation1.38332543
33MP0003136_yellow_coat_color1.37331888
34MP0005670_abnormal_white_adipose1.35940369
35MP0002233_abnormal_nose_morphology1.35361192
36MP0003938_abnormal_ear_development1.33657691
37MP0003890_abnormal_embryonic-extraembry1.32424670
38MP0003077_abnormal_cell_cycle1.32066262
39MP0009384_cardiac_valve_regurgitation1.30571815
40MP0000537_abnormal_urethra_morphology1.28467304
41MP0005408_hypopigmentation1.28371823
42MP0000049_abnormal_middle_ear1.27501074
43MP0005253_abnormal_eye_physiology1.27271256
44MP0003191_abnormal_cellular_cholesterol1.23928350
45MP0003186_abnormal_redox_activity1.23423665
46MP0001968_abnormal_touch/_nociception1.19287392
47MP0008932_abnormal_embryonic_tissue1.19077829
48MP0004133_heterotaxia1.17641274
49MP0008875_abnormal_xenobiotic_pharmacok1.12928188
50MP0002111_abnormal_tail_morphology1.12885860
51MP0003787_abnormal_imprinting1.12385238
52MP0001286_abnormal_eye_development1.12152586
53MP0003011_delayed_dark_adaptation1.11239645
54MP0004185_abnormal_adipocyte_glucose1.08339427
55MP0000427_abnormal_hair_cycle1.04867370
56MP0001849_ear_inflammation1.04309871
57MP0000428_abnormal_craniofacial_morphol1.02350711
58MP0006072_abnormal_retinal_apoptosis1.02152311
59MP0001529_abnormal_vocalization1.01957455
60MP0002160_abnormal_reproductive_system1.01853081
61MP0005551_abnormal_eye_electrophysiolog1.00813192
62MP0005195_abnormal_posterior_eye0.99810607
63MP0005197_abnormal_uvea_morphology0.99396681
64MP0008775_abnormal_heart_ventricle0.98848454
65MP0003121_genomic_imprinting0.97309442
66MP0003119_abnormal_digestive_system0.95040807
67MP0000026_abnormal_inner_ear0.94898932
68MP0001485_abnormal_pinna_reflex0.94022586
69MP0000631_abnormal_neuroendocrine_gland0.92722968
70MP0002735_abnormal_chemical_nociception0.90468013
71MP0001661_extended_life_span0.89915962
72MP0003937_abnormal_limbs/digits/tail_de0.88411987
73MP0002084_abnormal_developmental_patter0.87025108
74MP0005367_renal/urinary_system_phenotyp0.86255214
75MP0000516_abnormal_urinary_system0.86255214
76MP0001986_abnormal_taste_sensitivity0.85756510
77MP0001299_abnormal_eye_distance/0.85275555
78MP0001764_abnormal_homeostasis0.83856972
79MP0005646_abnormal_pituitary_gland0.83637651
80MP0009697_abnormal_copulation0.80142483
81MP0006035_abnormal_mitochondrial_morpho0.79334919
82MP0003942_abnormal_urinary_system0.78189449
83MP0001697_abnormal_embryo_size0.77875616
84MP0003936_abnormal_reproductive_system0.77355454
85MP0004142_abnormal_muscle_tone0.74393288
86MP0000462_abnormal_digestive_system0.74157819
87MP0002295_abnormal_pulmonary_circulatio0.72186762
88MP0002085_abnormal_embryonic_tissue0.71557859
89MP0002132_abnormal_respiratory_system0.70571603
90MP0005379_endocrine/exocrine_gland_phen0.67752853
91MP0000681_abnormal_thyroid_gland0.66967277
92MP0005389_reproductive_system_phenotype0.66316567
93MP0001324_abnormal_eye_pigmentation0.65348090
94MP0003755_abnormal_palate_morphology0.65104270
95MP0001145_abnormal_male_reproductive0.64129252
96MP0003315_abnormal_perineum_morphology0.61913214
97MP0002210_abnormal_sex_determination0.61270842
98MP0003385_abnormal_body_wall0.60981496
99MP0008961_abnormal_basal_metabolism0.60357084
100MP0000647_abnormal_sebaceous_gland0.58051130

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.83758092
2Lipid accumulation in hepatocytes (HP:0006561)4.77930254
3Abnormality of cells of the erythroid lineage (HP:0012130)4.07108068
4Acute necrotizing encephalopathy (HP:0006965)3.84262240
5Reticulocytopenia (HP:0001896)3.73064873
6Abnormal number of erythroid precursors (HP:0012131)3.71521916
7Mitochondrial inheritance (HP:0001427)3.69700476
8Stenosis of the external auditory canal (HP:0000402)3.59625278
9Septo-optic dysplasia (HP:0100842)3.59065205
10Abnormal mitochondria in muscle tissue (HP:0008316)3.57478434
11Renal Fanconi syndrome (HP:0001994)3.49714637
12Macrocytic anemia (HP:0001972)3.44026697
13Increased CSF lactate (HP:0002490)3.37970364
14Progressive macrocephaly (HP:0004481)3.37864784
15Hyperglycinemia (HP:0002154)3.37248025
16Type I transferrin isoform profile (HP:0003642)3.36101923
17Acute encephalopathy (HP:0006846)3.32571652
18Methylmalonic acidemia (HP:0002912)3.17678037
19Increased intramyocellular lipid droplets (HP:0012240)3.04926602
20Hyperglycinuria (HP:0003108)2.95720719
21Testicular atrophy (HP:0000029)2.94133161
22Cutaneous melanoma (HP:0012056)2.89949723
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79786477
24Abnormal protein N-linked glycosylation (HP:0012347)2.79786477
25Abnormal protein glycosylation (HP:0012346)2.79786477
26Abnormal glycosylation (HP:0012345)2.79786477
27Abnormality of serine family amino acid metabolism (HP:0010894)2.76699204
28Abnormality of glycine metabolism (HP:0010895)2.76699204
29Increased muscle lipid content (HP:0009058)2.76274057
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70348989
31Methylmalonic aciduria (HP:0012120)2.68894659
32Hepatocellular necrosis (HP:0001404)2.67908570
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.67053876
34Poor head control (HP:0002421)2.65791077
35Rectal fistula (HP:0100590)2.64617195
36Rectovaginal fistula (HP:0000143)2.64617195
37Colon cancer (HP:0003003)2.64446364
38Maternal diabetes (HP:0009800)2.59477304
39Absent thumb (HP:0009777)2.57824514
40Congenital, generalized hypertrichosis (HP:0004540)2.56989222
41Absent septum pellucidum (HP:0001331)2.55337294
42Megaloblastic anemia (HP:0001889)2.54716855
43Exertional dyspnea (HP:0002875)2.54026377
44Hepatic necrosis (HP:0002605)2.49515084
45Duplication of thumb phalanx (HP:0009942)2.49423614
46Pallor (HP:0000980)2.47071456
47Pancreatic fibrosis (HP:0100732)2.40366465
48Partial duplication of thumb phalanx (HP:0009944)2.36939637
49Respiratory difficulties (HP:0002880)2.35784359
50Cerebral edema (HP:0002181)2.35454739
51Rib fusion (HP:0000902)2.31976427
52Vaginal fistula (HP:0004320)2.25010097
53Myelomeningocele (HP:0002475)2.23505884
54Optic nerve hypoplasia (HP:0000609)2.17919285
55Abnormality of methionine metabolism (HP:0010901)2.13800721
56Nephronophthisis (HP:0000090)2.07672379
57Intestinal fistula (HP:0100819)2.06978751
58Partial duplication of the phalanx of hand (HP:0009999)2.02668061
59Abnormality of urine glucose concentration (HP:0011016)1.97602693
60Glycosuria (HP:0003076)1.97602693
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97438284
62Pendular nystagmus (HP:0012043)1.97327615
63Hypoplastic pelvis (HP:0008839)1.96687800
64Pancreatic cysts (HP:0001737)1.94928178
65Anophthalmia (HP:0000528)1.93864494
66Progressive muscle weakness (HP:0003323)1.93707043
67Pancytopenia (HP:0001876)1.92652329
68Postaxial foot polydactyly (HP:0001830)1.91953884
69Abnormality of the septum pellucidum (HP:0007375)1.91189706
70Abnormality of the labia minora (HP:0012880)1.90558366
71Abnormality of serum amino acid levels (HP:0003112)1.90508745
72Cutaneous finger syndactyly (HP:0010554)1.90274654
73Sclerocornea (HP:0000647)1.90227313
74Abnormal pupillary function (HP:0007686)1.87783826
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87104912
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87104912
77True hermaphroditism (HP:0010459)1.86944461
78Abnormal number of incisors (HP:0011064)1.86063774
79Triphalangeal thumb (HP:0001199)1.85545693
80Median cleft lip (HP:0000161)1.85472356
81Homocystinuria (HP:0002156)1.83950710
82Abnormality of homocysteine metabolism (HP:0010919)1.83950710
83Abnormality of renal resorption (HP:0011038)1.83328065
84Exercise intolerance (HP:0003546)1.82145679
85Increased serum lactate (HP:0002151)1.81457463
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81419120
87Abnormality of vitamin B metabolism (HP:0004340)1.80619869
88Short 4th metacarpal (HP:0010044)1.80310720
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80310720
90Beaking of vertebral bodies (HP:0004568)1.79472717
91Ectopic kidney (HP:0000086)1.79199888
92Cutaneous syndactyly (HP:0012725)1.77825283
93Type 2 muscle fiber atrophy (HP:0003554)1.77703548
94Decreased central vision (HP:0007663)1.77484547
95Lethargy (HP:0001254)1.76463605
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.76064535
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74737102
98Abnormality of the phalanges of the hallux (HP:0010057)1.74569344
99Abnormality of the vitamin B12 metabolism (HP:0004341)1.74511695
100Lactic acidosis (HP:0003128)1.74370485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.50475293
2NEK13.72927638
3FGFR23.59824405
4CDC73.13176006
5MAP2K72.78763030
6MAP3K132.43814991
7MAP3K42.40751004
8FRK2.30978010
9BMPR1B2.21159774
10MST42.17989692
11NEK22.12856148
12NME12.05779436
13SRPK12.02804807
14TNIK2.01715122
15VRK12.00691307
16STK391.98796024
17BUB11.91165324
18PBK1.66102402
19DYRK31.65678567
20STK31.60299751
21OXSR11.58674548
22PIK3CA1.52411202
23PLK31.47703785
24EIF2AK11.43463164
25CSNK1G31.42454309
26PLK11.39695304
27WNK41.35978055
28TTK1.32241307
29RPS6KA41.30811587
30AURKB1.30726325
31BCKDK1.25909685
32DYRK21.22925666
33MAP4K21.21524823
34EPHA41.16685530
35CSNK1G11.14606119
36CDK81.14354196
37ARAF1.13406877
38CDK191.12893688
39EPHA21.12892063
40PASK1.07804112
41CSNK1G21.06273441
42MKNK11.03889515
43CASK1.01919129
44FLT30.94342086
45STK40.91674308
46STK240.88660187
47ZAK0.88257099
48AURKA0.86429354
49ATR0.86153916
50PAK20.83603172
51LATS10.82374894
52PLK40.78669942
53NUAK10.77653332
54TLK10.75463520
55IRAK40.73280305
56STK160.73101610
57EPHA30.72617791
58TAF10.71079381
59BRAF0.70423380
60STK38L0.69602296
61TGFBR10.68623290
62GRK10.67370252
63CDK90.66566009
64NME20.65726565
65CDK70.65612819
66WNK30.63359544
67CSNK2A20.61356603
68PIM20.58231713
69ADRBK20.57905591
70CSNK2A10.57376406
71AKT30.56947138
72PTK20.50717507
73FGFR10.50592706
74PNCK0.50230243
75CHEK20.49783861
76PRKACB0.49575549
77CHEK10.48710892
78CDK30.46046087
79MAP3K120.45512129
80MAP3K100.45078735
81MET0.43186015
82CSNK1A1L0.42672479
83IRAK10.40321939
84CDK40.39005321
85ATM0.38724496
86EPHB20.38255945
87EIF2AK30.37219619
88CAMK2G0.37064122
89CSNK1D0.35718629
90RPS6KA50.34105927
91ERBB40.33686080
92MKNK20.33185073
93MAP2K40.32716255
94SIK10.32713631
95DYRK1B0.31589718
96PHKG10.31284881
97PHKG20.31284881
98IRAK20.30891533
99MYLK0.29068945
100MAP3K90.28716641

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.40459673
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59432584
3Proteasome_Homo sapiens_hsa030503.58157122
4Oxidative phosphorylation_Homo sapiens_hsa001903.45381117
5DNA replication_Homo sapiens_hsa030302.91891378
6RNA polymerase_Homo sapiens_hsa030202.91253265
7Mismatch repair_Homo sapiens_hsa034302.82659619
8Parkinsons disease_Homo sapiens_hsa050122.79460506
9Protein export_Homo sapiens_hsa030602.51769446
10Base excision repair_Homo sapiens_hsa034102.50680525
11Homologous recombination_Homo sapiens_hsa034402.38800783
12Huntingtons disease_Homo sapiens_hsa050162.20139376
13Spliceosome_Homo sapiens_hsa030402.07132561
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01976554
15Nucleotide excision repair_Homo sapiens_hsa034201.94814561
16Alzheimers disease_Homo sapiens_hsa050101.84450036
17Pyrimidine metabolism_Homo sapiens_hsa002401.78589883
18Sulfur metabolism_Homo sapiens_hsa009201.77413346
19Fanconi anemia pathway_Homo sapiens_hsa034601.71323579
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65380483
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61502794
22Butanoate metabolism_Homo sapiens_hsa006501.60377920
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58864197
24Sulfur relay system_Homo sapiens_hsa041221.52119904
25Purine metabolism_Homo sapiens_hsa002301.49605639
26RNA degradation_Homo sapiens_hsa030181.44294911
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43718126
28Basal cell carcinoma_Homo sapiens_hsa052171.40505020
29RNA transport_Homo sapiens_hsa030131.40390975
30One carbon pool by folate_Homo sapiens_hsa006701.40336894
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33850711
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28237756
33Pyruvate metabolism_Homo sapiens_hsa006201.27659553
34Selenocompound metabolism_Homo sapiens_hsa004501.26083556
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24359413
36Peroxisome_Homo sapiens_hsa041461.23817018
37Phototransduction_Homo sapiens_hsa047441.22772491
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15769631
39Non-homologous end-joining_Homo sapiens_hsa034501.15478832
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.12237242
41Cardiac muscle contraction_Homo sapiens_hsa042601.11484732
42Steroid biosynthesis_Homo sapiens_hsa001001.10374344
43Folate biosynthesis_Homo sapiens_hsa007901.08026999
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04567620
45Propanoate metabolism_Homo sapiens_hsa006401.01542801
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00394328
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98957916
48Basal transcription factors_Homo sapiens_hsa030220.96442112
49Fatty acid elongation_Homo sapiens_hsa000620.93609036
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.91537998
51Tryptophan metabolism_Homo sapiens_hsa003800.89212088
52Vitamin digestion and absorption_Homo sapiens_hsa049770.82909572
53Other glycan degradation_Homo sapiens_hsa005110.78806534
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.77164058
55Metabolic pathways_Homo sapiens_hsa011000.76881318
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72271852
57Hedgehog signaling pathway_Homo sapiens_hsa043400.68242838
58Glutathione metabolism_Homo sapiens_hsa004800.67717576
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67204830
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66142484
61Hippo signaling pathway_Homo sapiens_hsa043900.60774666
62Caffeine metabolism_Homo sapiens_hsa002320.59807761
63Fatty acid degradation_Homo sapiens_hsa000710.58833280
64beta-Alanine metabolism_Homo sapiens_hsa004100.58574214
65p53 signaling pathway_Homo sapiens_hsa041150.57814895
66Cell cycle_Homo sapiens_hsa041100.53705028
67Collecting duct acid secretion_Homo sapiens_hsa049660.53289725
68N-Glycan biosynthesis_Homo sapiens_hsa005100.51198988
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.48393605
70Retinol metabolism_Homo sapiens_hsa008300.47378283
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44873479
72Wnt signaling pathway_Homo sapiens_hsa043100.42642737
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41330638
74Lysine degradation_Homo sapiens_hsa003100.40945656
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40936400
76Glycerolipid metabolism_Homo sapiens_hsa005610.40798754
77Biosynthesis of amino acids_Homo sapiens_hsa012300.39689821
78Arginine and proline metabolism_Homo sapiens_hsa003300.37704872
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36886861
80Regulation of autophagy_Homo sapiens_hsa041400.36626605
81Fatty acid metabolism_Homo sapiens_hsa012120.35429105
82TGF-beta signaling pathway_Homo sapiens_hsa043500.35067987
83Carbon metabolism_Homo sapiens_hsa012000.34808398
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34741205
85Chemical carcinogenesis_Homo sapiens_hsa052040.34524947
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33098342
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30555516
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29125072
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27812436
90mRNA surveillance pathway_Homo sapiens_hsa030150.24755744
91Thyroid cancer_Homo sapiens_hsa052160.24028899
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23384756
93Nitrogen metabolism_Homo sapiens_hsa009100.20924951
94Arachidonic acid metabolism_Homo sapiens_hsa005900.20295897
95Sphingolipid metabolism_Homo sapiens_hsa006000.16230067
96Oocyte meiosis_Homo sapiens_hsa041140.14990644
97Vitamin B6 metabolism_Homo sapiens_hsa007500.14475839
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13178919
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10152844
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07669531

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