

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chaperone-mediated protein transport (GO:0072321) | 6.55180634 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.76158381 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.48633611 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.48633611 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.46114341 |
| 6 | kinetochore assembly (GO:0051382) | 4.93069522 |
| 7 | kinetochore organization (GO:0051383) | 4.83616906 |
| 8 | regulation of mitochondrial translation (GO:0070129) | 4.81172935 |
| 9 | viral transcription (GO:0019083) | 4.78050125 |
| 10 | translational termination (GO:0006415) | 4.59100215 |
| 11 | ribosomal small subunit biogenesis (GO:0042274) | 4.45093471 |
| 12 | rRNA modification (GO:0000154) | 4.44801374 |
| 13 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.34245810 |
| 14 | cotranslational protein targeting to membrane (GO:0006613) | 4.32050426 |
| 15 | protein targeting to ER (GO:0045047) | 4.28721362 |
| 16 | protein complex biogenesis (GO:0070271) | 4.27712254 |
| 17 | ribosomal small subunit assembly (GO:0000028) | 4.21533964 |
| 18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.11342061 |
| 19 | peptidyl-histidine modification (GO:0018202) | 4.10285811 |
| 20 | chromatin remodeling at centromere (GO:0031055) | 4.09537272 |
| 21 | protein localization to endoplasmic reticulum (GO:0070972) | 4.09206279 |
| 22 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.01513477 |
| 23 | pseudouridine synthesis (GO:0001522) | 3.94728768 |
| 24 | base-excision repair, AP site formation (GO:0006285) | 3.93529013 |
| 25 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.89888863 |
| 26 | translational elongation (GO:0006414) | 3.86736874 |
| 27 | proteasome assembly (GO:0043248) | 3.84671099 |
| 28 | inner mitochondrial membrane organization (GO:0007007) | 3.81038256 |
| 29 | GMP metabolic process (GO:0046037) | 3.79129258 |
| 30 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.77899083 |
| 31 | CENP-A containing nucleosome assembly (GO:0034080) | 3.77406076 |
| 32 | ribosomal large subunit biogenesis (GO:0042273) | 3.72433900 |
| 33 | maturation of SSU-rRNA (GO:0030490) | 3.65433318 |
| 34 | respiratory electron transport chain (GO:0022904) | 3.63124145 |
| 35 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.62221671 |
| 36 | NADH dehydrogenase complex assembly (GO:0010257) | 3.62221671 |
| 37 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.62221671 |
| 38 | electron transport chain (GO:0022900) | 3.60782388 |
| 39 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.60148517 |
| 40 | termination of RNA polymerase III transcription (GO:0006386) | 3.60148517 |
| 41 | viral life cycle (GO:0019058) | 3.59812117 |
| 42 | cell wall macromolecule catabolic process (GO:0016998) | 3.57802212 |
| 43 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.56678852 |
| 44 | translational initiation (GO:0006413) | 3.55376903 |
| 45 | purine nucleobase biosynthetic process (GO:0009113) | 3.54901022 |
| 46 | resolution of meiotic recombination intermediates (GO:0000712) | 3.53963119 |
| 47 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.51348807 |
| 48 | cellular component biogenesis (GO:0044085) | 3.42138239 |
| 49 | cellular protein complex disassembly (GO:0043624) | 3.41550062 |
| 50 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.41099341 |
| 51 | nucleobase biosynthetic process (GO:0046112) | 3.38791337 |
| 52 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 3.32936419 |
| 53 | intracellular protein transmembrane import (GO:0044743) | 3.30862332 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.28489898 |
| 55 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.28172142 |
| 56 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.27300695 |
| 57 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.27300695 |
| 58 | metaphase plate congression (GO:0051310) | 3.24116266 |
| 59 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.19818871 |
| 60 | translation (GO:0006412) | 3.19098761 |
| 61 | mitochondrion morphogenesis (GO:0070584) | 3.18426914 |
| 62 | rRNA methylation (GO:0031167) | 3.18223956 |
| 63 | establishment of integrated proviral latency (GO:0075713) | 3.16402425 |
| 64 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.13297028 |
| 65 | protein targeting to mitochondrion (GO:0006626) | 3.12010472 |
| 66 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.11034236 |
| 67 | DNA strand elongation (GO:0022616) | 3.08007066 |
| 68 | lysine catabolic process (GO:0006554) | 3.07094358 |
| 69 | lysine metabolic process (GO:0006553) | 3.07094358 |
| 70 | IMP biosynthetic process (GO:0006188) | 3.06921331 |
| 71 | protein neddylation (GO:0045116) | 3.06399897 |
| 72 | spliceosomal snRNP assembly (GO:0000387) | 3.04062174 |
| 73 | heterochromatin organization (GO:0070828) | 3.02825907 |
| 74 | respiratory chain complex IV assembly (GO:0008535) | 3.01257715 |
| 75 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.01248522 |
| 76 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.00603378 |
| 77 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.00029913 |
| 78 | histone exchange (GO:0043486) | 2.97428647 |
| 79 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.97333764 |
| 80 | DNA replication-independent nucleosome organization (GO:0034724) | 2.97333764 |
| 81 | rRNA processing (GO:0006364) | 2.96970330 |
| 82 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.96737038 |
| 83 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.95296782 |
| 84 | mannosylation (GO:0097502) | 2.94209338 |
| 85 | rRNA metabolic process (GO:0016072) | 2.92247092 |
| 86 | protein complex disassembly (GO:0043241) | 2.92053357 |
| 87 | cell wall macromolecule metabolic process (GO:0044036) | 2.90283774 |
| 88 | protein targeting to membrane (GO:0006612) | 2.90281072 |
| 89 | negative regulation of telomerase activity (GO:0051974) | 2.90138589 |
| 90 | establishment of protein localization to mitochondrion (GO:0072655) | 2.89883686 |
| 91 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.89859608 |
| 92 | cellular ketone body metabolic process (GO:0046950) | 2.86588086 |
| 93 | DNA replication checkpoint (GO:0000076) | 2.86400418 |
| 94 | ATP biosynthetic process (GO:0006754) | 2.86134418 |
| 95 | protein polyglutamylation (GO:0018095) | 2.85008908 |
| 96 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.83907847 |
| 97 | negative regulation of ligase activity (GO:0051352) | 2.82132016 |
| 98 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.82132016 |
| 99 | macromolecular complex disassembly (GO:0032984) | 2.79522982 |
| 100 | lateral sprouting from an epithelium (GO:0060601) | 2.79122980 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 7.22283880 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.60452450 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.49954176 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.12672460 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.65055658 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.60964993 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.18233156 |
| 8 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.07765156 |
| 9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.02233266 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.98096490 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.98068846 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.97002917 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79890656 |
| 14 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.79633421 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.74409673 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71946888 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.61255897 |
| 18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.57950173 |
| 19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.48872902 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.37010235 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.35142976 |
| 22 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.32087943 |
| 23 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.26351865 |
| 24 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.25991005 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.24931864 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.23322302 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.22312594 |
| 28 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.21335261 |
| 29 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.15383293 |
| 30 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.06285299 |
| 31 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.03048875 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.99183405 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.98336668 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.97236150 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.94244649 |
| 36 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.84777687 |
| 37 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.82395605 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.82385228 |
| 39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.79805410 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.79600869 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.78388678 |
| 42 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.73227030 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.64627391 |
| 44 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.60929998 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.59228203 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.57193847 |
| 47 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.52589101 |
| 48 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.50990948 |
| 49 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.50479718 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48083156 |
| 51 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.45620532 |
| 52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.42227433 |
| 53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.35803819 |
| 54 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32581276 |
| 55 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.32341434 |
| 56 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.31784092 |
| 57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.27988244 |
| 58 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.27289394 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.25171047 |
| 60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24057410 |
| 61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22810728 |
| 62 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.22203210 |
| 63 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.20426193 |
| 64 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.17992749 |
| 65 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.16602455 |
| 66 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.15917547 |
| 67 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.15009309 |
| 68 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.14648490 |
| 69 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.13337116 |
| 70 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10897005 |
| 71 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09928381 |
| 72 | FUS_26573619_Chip-Seq_HEK293_Human | 1.09413376 |
| 73 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06313781 |
| 74 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.06042091 |
| 75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05868152 |
| 76 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.02480534 |
| 77 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02041626 |
| 78 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00659054 |
| 79 | EWS_26573619_Chip-Seq_HEK293_Human | 0.99544039 |
| 80 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.96580748 |
| 81 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.96435460 |
| 82 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.95463093 |
| 83 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.93580898 |
| 84 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.88817145 |
| 85 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.85907920 |
| 86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.84050077 |
| 87 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.83707975 |
| 88 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.83189009 |
| 89 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.80642513 |
| 90 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.79861117 |
| 91 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78322578 |
| 92 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.74735620 |
| 93 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.73443911 |
| 94 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.72025642 |
| 95 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.70539412 |
| 96 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.70075407 |
| 97 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.69001235 |
| 98 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.68640137 |
| 99 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.68011298 |
| 100 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.67372448 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010030_abnormal_orbit_morphology | 6.00227936 |
| 2 | MP0006292_abnormal_olfactory_placode | 5.29972735 |
| 3 | MP0001346_abnormal_lacrimal_gland | 3.52734508 |
| 4 | MP0009379_abnormal_foot_pigmentation | 3.18918743 |
| 5 | MP0000566_synostosis | 3.10328021 |
| 6 | MP0001293_anophthalmia | 2.96672196 |
| 7 | MP0008789_abnormal_olfactory_epithelium | 2.85600058 |
| 8 | MP0002938_white_spotting | 2.65992487 |
| 9 | MP0002638_abnormal_pupillary_reflex | 2.35620795 |
| 10 | MP0005248_abnormal_Harderian_gland | 2.34237077 |
| 11 | MP0003718_maternal_effect | 2.22024267 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.15890845 |
| 13 | MP0001905_abnormal_dopamine_level | 2.04818735 |
| 14 | MP0003693_abnormal_embryo_hatching | 1.88252156 |
| 15 | MP0003941_abnormal_skin_development | 1.83367869 |
| 16 | MP0002653_abnormal_ependyma_morphology | 1.79357340 |
| 17 | MP0000579_abnormal_nail_morphology | 1.71902148 |
| 18 | MP0008058_abnormal_DNA_repair | 1.71343645 |
| 19 | MP0005394_taste/olfaction_phenotype | 1.69207051 |
| 20 | MP0005499_abnormal_olfactory_system | 1.69207051 |
| 21 | MP0010094_abnormal_chromosome_stability | 1.61924374 |
| 22 | MP0002736_abnormal_nociception_after | 1.61374311 |
| 23 | MP0004957_abnormal_blastocyst_morpholog | 1.61327052 |
| 24 | MP0001984_abnormal_olfaction | 1.57267029 |
| 25 | MP0002697_abnormal_eye_size | 1.56767239 |
| 26 | MP0003111_abnormal_nucleus_morphology | 1.52782864 |
| 27 | MP0005391_vision/eye_phenotype | 1.46103573 |
| 28 | MP0002102_abnormal_ear_morphology | 1.42594467 |
| 29 | MP0002234_abnormal_pharynx_morphology | 1.41849783 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.39606880 |
| 31 | MP0002092_abnormal_eye_morphology | 1.39533542 |
| 32 | MP0005171_absent_coat_pigmentation | 1.38332543 |
| 33 | MP0003136_yellow_coat_color | 1.37331888 |
| 34 | MP0005670_abnormal_white_adipose | 1.35940369 |
| 35 | MP0002233_abnormal_nose_morphology | 1.35361192 |
| 36 | MP0003938_abnormal_ear_development | 1.33657691 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.32424670 |
| 38 | MP0003077_abnormal_cell_cycle | 1.32066262 |
| 39 | MP0009384_cardiac_valve_regurgitation | 1.30571815 |
| 40 | MP0000537_abnormal_urethra_morphology | 1.28467304 |
| 41 | MP0005408_hypopigmentation | 1.28371823 |
| 42 | MP0000049_abnormal_middle_ear | 1.27501074 |
| 43 | MP0005253_abnormal_eye_physiology | 1.27271256 |
| 44 | MP0003191_abnormal_cellular_cholesterol | 1.23928350 |
| 45 | MP0003186_abnormal_redox_activity | 1.23423665 |
| 46 | MP0001968_abnormal_touch/_nociception | 1.19287392 |
| 47 | MP0008932_abnormal_embryonic_tissue | 1.19077829 |
| 48 | MP0004133_heterotaxia | 1.17641274 |
| 49 | MP0008875_abnormal_xenobiotic_pharmacok | 1.12928188 |
| 50 | MP0002111_abnormal_tail_morphology | 1.12885860 |
| 51 | MP0003787_abnormal_imprinting | 1.12385238 |
| 52 | MP0001286_abnormal_eye_development | 1.12152586 |
| 53 | MP0003011_delayed_dark_adaptation | 1.11239645 |
| 54 | MP0004185_abnormal_adipocyte_glucose | 1.08339427 |
| 55 | MP0000427_abnormal_hair_cycle | 1.04867370 |
| 56 | MP0001849_ear_inflammation | 1.04309871 |
| 57 | MP0000428_abnormal_craniofacial_morphol | 1.02350711 |
| 58 | MP0006072_abnormal_retinal_apoptosis | 1.02152311 |
| 59 | MP0001529_abnormal_vocalization | 1.01957455 |
| 60 | MP0002160_abnormal_reproductive_system | 1.01853081 |
| 61 | MP0005551_abnormal_eye_electrophysiolog | 1.00813192 |
| 62 | MP0005195_abnormal_posterior_eye | 0.99810607 |
| 63 | MP0005197_abnormal_uvea_morphology | 0.99396681 |
| 64 | MP0008775_abnormal_heart_ventricle | 0.98848454 |
| 65 | MP0003121_genomic_imprinting | 0.97309442 |
| 66 | MP0003119_abnormal_digestive_system | 0.95040807 |
| 67 | MP0000026_abnormal_inner_ear | 0.94898932 |
| 68 | MP0001485_abnormal_pinna_reflex | 0.94022586 |
| 69 | MP0000631_abnormal_neuroendocrine_gland | 0.92722968 |
| 70 | MP0002735_abnormal_chemical_nociception | 0.90468013 |
| 71 | MP0001661_extended_life_span | 0.89915962 |
| 72 | MP0003937_abnormal_limbs/digits/tail_de | 0.88411987 |
| 73 | MP0002084_abnormal_developmental_patter | 0.87025108 |
| 74 | MP0005367_renal/urinary_system_phenotyp | 0.86255214 |
| 75 | MP0000516_abnormal_urinary_system | 0.86255214 |
| 76 | MP0001986_abnormal_taste_sensitivity | 0.85756510 |
| 77 | MP0001299_abnormal_eye_distance/ | 0.85275555 |
| 78 | MP0001764_abnormal_homeostasis | 0.83856972 |
| 79 | MP0005646_abnormal_pituitary_gland | 0.83637651 |
| 80 | MP0009697_abnormal_copulation | 0.80142483 |
| 81 | MP0006035_abnormal_mitochondrial_morpho | 0.79334919 |
| 82 | MP0003942_abnormal_urinary_system | 0.78189449 |
| 83 | MP0001697_abnormal_embryo_size | 0.77875616 |
| 84 | MP0003936_abnormal_reproductive_system | 0.77355454 |
| 85 | MP0004142_abnormal_muscle_tone | 0.74393288 |
| 86 | MP0000462_abnormal_digestive_system | 0.74157819 |
| 87 | MP0002295_abnormal_pulmonary_circulatio | 0.72186762 |
| 88 | MP0002085_abnormal_embryonic_tissue | 0.71557859 |
| 89 | MP0002132_abnormal_respiratory_system | 0.70571603 |
| 90 | MP0005379_endocrine/exocrine_gland_phen | 0.67752853 |
| 91 | MP0000681_abnormal_thyroid_gland | 0.66967277 |
| 92 | MP0005389_reproductive_system_phenotype | 0.66316567 |
| 93 | MP0001324_abnormal_eye_pigmentation | 0.65348090 |
| 94 | MP0003755_abnormal_palate_morphology | 0.65104270 |
| 95 | MP0001145_abnormal_male_reproductive | 0.64129252 |
| 96 | MP0003315_abnormal_perineum_morphology | 0.61913214 |
| 97 | MP0002210_abnormal_sex_determination | 0.61270842 |
| 98 | MP0003385_abnormal_body_wall | 0.60981496 |
| 99 | MP0008961_abnormal_basal_metabolism | 0.60357084 |
| 100 | MP0000647_abnormal_sebaceous_gland | 0.58051130 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.83758092 |
| 2 | Lipid accumulation in hepatocytes (HP:0006561) | 4.77930254 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.07108068 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 3.84262240 |
| 5 | Reticulocytopenia (HP:0001896) | 3.73064873 |
| 6 | Abnormal number of erythroid precursors (HP:0012131) | 3.71521916 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.69700476 |
| 8 | Stenosis of the external auditory canal (HP:0000402) | 3.59625278 |
| 9 | Septo-optic dysplasia (HP:0100842) | 3.59065205 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.57478434 |
| 11 | Renal Fanconi syndrome (HP:0001994) | 3.49714637 |
| 12 | Macrocytic anemia (HP:0001972) | 3.44026697 |
| 13 | Increased CSF lactate (HP:0002490) | 3.37970364 |
| 14 | Progressive macrocephaly (HP:0004481) | 3.37864784 |
| 15 | Hyperglycinemia (HP:0002154) | 3.37248025 |
| 16 | Type I transferrin isoform profile (HP:0003642) | 3.36101923 |
| 17 | Acute encephalopathy (HP:0006846) | 3.32571652 |
| 18 | Methylmalonic acidemia (HP:0002912) | 3.17678037 |
| 19 | Increased intramyocellular lipid droplets (HP:0012240) | 3.04926602 |
| 20 | Hyperglycinuria (HP:0003108) | 2.95720719 |
| 21 | Testicular atrophy (HP:0000029) | 2.94133161 |
| 22 | Cutaneous melanoma (HP:0012056) | 2.89949723 |
| 23 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.79786477 |
| 24 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.79786477 |
| 25 | Abnormal protein glycosylation (HP:0012346) | 2.79786477 |
| 26 | Abnormal glycosylation (HP:0012345) | 2.79786477 |
| 27 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.76699204 |
| 28 | Abnormality of glycine metabolism (HP:0010895) | 2.76699204 |
| 29 | Increased muscle lipid content (HP:0009058) | 2.76274057 |
| 30 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.70348989 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.68894659 |
| 32 | Hepatocellular necrosis (HP:0001404) | 2.67908570 |
| 33 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.67053876 |
| 34 | Poor head control (HP:0002421) | 2.65791077 |
| 35 | Rectal fistula (HP:0100590) | 2.64617195 |
| 36 | Rectovaginal fistula (HP:0000143) | 2.64617195 |
| 37 | Colon cancer (HP:0003003) | 2.64446364 |
| 38 | Maternal diabetes (HP:0009800) | 2.59477304 |
| 39 | Absent thumb (HP:0009777) | 2.57824514 |
| 40 | Congenital, generalized hypertrichosis (HP:0004540) | 2.56989222 |
| 41 | Absent septum pellucidum (HP:0001331) | 2.55337294 |
| 42 | Megaloblastic anemia (HP:0001889) | 2.54716855 |
| 43 | Exertional dyspnea (HP:0002875) | 2.54026377 |
| 44 | Hepatic necrosis (HP:0002605) | 2.49515084 |
| 45 | Duplication of thumb phalanx (HP:0009942) | 2.49423614 |
| 46 | Pallor (HP:0000980) | 2.47071456 |
| 47 | Pancreatic fibrosis (HP:0100732) | 2.40366465 |
| 48 | Partial duplication of thumb phalanx (HP:0009944) | 2.36939637 |
| 49 | Respiratory difficulties (HP:0002880) | 2.35784359 |
| 50 | Cerebral edema (HP:0002181) | 2.35454739 |
| 51 | Rib fusion (HP:0000902) | 2.31976427 |
| 52 | Vaginal fistula (HP:0004320) | 2.25010097 |
| 53 | Myelomeningocele (HP:0002475) | 2.23505884 |
| 54 | Optic nerve hypoplasia (HP:0000609) | 2.17919285 |
| 55 | Abnormality of methionine metabolism (HP:0010901) | 2.13800721 |
| 56 | Nephronophthisis (HP:0000090) | 2.07672379 |
| 57 | Intestinal fistula (HP:0100819) | 2.06978751 |
| 58 | Partial duplication of the phalanx of hand (HP:0009999) | 2.02668061 |
| 59 | Abnormality of urine glucose concentration (HP:0011016) | 1.97602693 |
| 60 | Glycosuria (HP:0003076) | 1.97602693 |
| 61 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.97438284 |
| 62 | Pendular nystagmus (HP:0012043) | 1.97327615 |
| 63 | Hypoplastic pelvis (HP:0008839) | 1.96687800 |
| 64 | Pancreatic cysts (HP:0001737) | 1.94928178 |
| 65 | Anophthalmia (HP:0000528) | 1.93864494 |
| 66 | Progressive muscle weakness (HP:0003323) | 1.93707043 |
| 67 | Pancytopenia (HP:0001876) | 1.92652329 |
| 68 | Postaxial foot polydactyly (HP:0001830) | 1.91953884 |
| 69 | Abnormality of the septum pellucidum (HP:0007375) | 1.91189706 |
| 70 | Abnormality of the labia minora (HP:0012880) | 1.90558366 |
| 71 | Abnormality of serum amino acid levels (HP:0003112) | 1.90508745 |
| 72 | Cutaneous finger syndactyly (HP:0010554) | 1.90274654 |
| 73 | Sclerocornea (HP:0000647) | 1.90227313 |
| 74 | Abnormal pupillary function (HP:0007686) | 1.87783826 |
| 75 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.87104912 |
| 76 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.87104912 |
| 77 | True hermaphroditism (HP:0010459) | 1.86944461 |
| 78 | Abnormal number of incisors (HP:0011064) | 1.86063774 |
| 79 | Triphalangeal thumb (HP:0001199) | 1.85545693 |
| 80 | Median cleft lip (HP:0000161) | 1.85472356 |
| 81 | Homocystinuria (HP:0002156) | 1.83950710 |
| 82 | Abnormality of homocysteine metabolism (HP:0010919) | 1.83950710 |
| 83 | Abnormality of renal resorption (HP:0011038) | 1.83328065 |
| 84 | Exercise intolerance (HP:0003546) | 1.82145679 |
| 85 | Increased serum lactate (HP:0002151) | 1.81457463 |
| 86 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.81419120 |
| 87 | Abnormality of vitamin B metabolism (HP:0004340) | 1.80619869 |
| 88 | Short 4th metacarpal (HP:0010044) | 1.80310720 |
| 89 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.80310720 |
| 90 | Beaking of vertebral bodies (HP:0004568) | 1.79472717 |
| 91 | Ectopic kidney (HP:0000086) | 1.79199888 |
| 92 | Cutaneous syndactyly (HP:0012725) | 1.77825283 |
| 93 | Type 2 muscle fiber atrophy (HP:0003554) | 1.77703548 |
| 94 | Decreased central vision (HP:0007663) | 1.77484547 |
| 95 | Lethargy (HP:0001254) | 1.76463605 |
| 96 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.76064535 |
| 97 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.74737102 |
| 98 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.74569344 |
| 99 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.74511695 |
| 100 | Lactic acidosis (HP:0003128) | 1.74370485 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.50475293 |
| 2 | NEK1 | 3.72927638 |
| 3 | FGFR2 | 3.59824405 |
| 4 | CDC7 | 3.13176006 |
| 5 | MAP2K7 | 2.78763030 |
| 6 | MAP3K13 | 2.43814991 |
| 7 | MAP3K4 | 2.40751004 |
| 8 | FRK | 2.30978010 |
| 9 | BMPR1B | 2.21159774 |
| 10 | MST4 | 2.17989692 |
| 11 | NEK2 | 2.12856148 |
| 12 | NME1 | 2.05779436 |
| 13 | SRPK1 | 2.02804807 |
| 14 | TNIK | 2.01715122 |
| 15 | VRK1 | 2.00691307 |
| 16 | STK39 | 1.98796024 |
| 17 | BUB1 | 1.91165324 |
| 18 | PBK | 1.66102402 |
| 19 | DYRK3 | 1.65678567 |
| 20 | STK3 | 1.60299751 |
| 21 | OXSR1 | 1.58674548 |
| 22 | PIK3CA | 1.52411202 |
| 23 | PLK3 | 1.47703785 |
| 24 | EIF2AK1 | 1.43463164 |
| 25 | CSNK1G3 | 1.42454309 |
| 26 | PLK1 | 1.39695304 |
| 27 | WNK4 | 1.35978055 |
| 28 | TTK | 1.32241307 |
| 29 | RPS6KA4 | 1.30811587 |
| 30 | AURKB | 1.30726325 |
| 31 | BCKDK | 1.25909685 |
| 32 | DYRK2 | 1.22925666 |
| 33 | MAP4K2 | 1.21524823 |
| 34 | EPHA4 | 1.16685530 |
| 35 | CSNK1G1 | 1.14606119 |
| 36 | CDK8 | 1.14354196 |
| 37 | ARAF | 1.13406877 |
| 38 | CDK19 | 1.12893688 |
| 39 | EPHA2 | 1.12892063 |
| 40 | PASK | 1.07804112 |
| 41 | CSNK1G2 | 1.06273441 |
| 42 | MKNK1 | 1.03889515 |
| 43 | CASK | 1.01919129 |
| 44 | FLT3 | 0.94342086 |
| 45 | STK4 | 0.91674308 |
| 46 | STK24 | 0.88660187 |
| 47 | ZAK | 0.88257099 |
| 48 | AURKA | 0.86429354 |
| 49 | ATR | 0.86153916 |
| 50 | PAK2 | 0.83603172 |
| 51 | LATS1 | 0.82374894 |
| 52 | PLK4 | 0.78669942 |
| 53 | NUAK1 | 0.77653332 |
| 54 | TLK1 | 0.75463520 |
| 55 | IRAK4 | 0.73280305 |
| 56 | STK16 | 0.73101610 |
| 57 | EPHA3 | 0.72617791 |
| 58 | TAF1 | 0.71079381 |
| 59 | BRAF | 0.70423380 |
| 60 | STK38L | 0.69602296 |
| 61 | TGFBR1 | 0.68623290 |
| 62 | GRK1 | 0.67370252 |
| 63 | CDK9 | 0.66566009 |
| 64 | NME2 | 0.65726565 |
| 65 | CDK7 | 0.65612819 |
| 66 | WNK3 | 0.63359544 |
| 67 | CSNK2A2 | 0.61356603 |
| 68 | PIM2 | 0.58231713 |
| 69 | ADRBK2 | 0.57905591 |
| 70 | CSNK2A1 | 0.57376406 |
| 71 | AKT3 | 0.56947138 |
| 72 | PTK2 | 0.50717507 |
| 73 | FGFR1 | 0.50592706 |
| 74 | PNCK | 0.50230243 |
| 75 | CHEK2 | 0.49783861 |
| 76 | PRKACB | 0.49575549 |
| 77 | CHEK1 | 0.48710892 |
| 78 | CDK3 | 0.46046087 |
| 79 | MAP3K12 | 0.45512129 |
| 80 | MAP3K10 | 0.45078735 |
| 81 | MET | 0.43186015 |
| 82 | CSNK1A1L | 0.42672479 |
| 83 | IRAK1 | 0.40321939 |
| 84 | CDK4 | 0.39005321 |
| 85 | ATM | 0.38724496 |
| 86 | EPHB2 | 0.38255945 |
| 87 | EIF2AK3 | 0.37219619 |
| 88 | CAMK2G | 0.37064122 |
| 89 | CSNK1D | 0.35718629 |
| 90 | RPS6KA5 | 0.34105927 |
| 91 | ERBB4 | 0.33686080 |
| 92 | MKNK2 | 0.33185073 |
| 93 | MAP2K4 | 0.32716255 |
| 94 | SIK1 | 0.32713631 |
| 95 | DYRK1B | 0.31589718 |
| 96 | PHKG1 | 0.31284881 |
| 97 | PHKG2 | 0.31284881 |
| 98 | IRAK2 | 0.30891533 |
| 99 | MYLK | 0.29068945 |
| 100 | MAP3K9 | 0.28716641 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.40459673 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.59432584 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.58157122 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.45381117 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.91891378 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.91253265 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.82659619 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.79460506 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.51769446 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.50680525 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.38800783 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.20139376 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.07132561 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.01976554 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.94814561 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.84450036 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.78589883 |
| 18 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.77413346 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.71323579 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.65380483 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.61502794 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.60377920 |
| 23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.58864197 |
| 24 | Sulfur relay system_Homo sapiens_hsa04122 | 1.52119904 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.49605639 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.44294911 |
| 27 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.43718126 |
| 28 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.40505020 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.40390975 |
| 30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.40336894 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33850711 |
| 32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.28237756 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.27659553 |
| 34 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.26083556 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.24359413 |
| 36 | Peroxisome_Homo sapiens_hsa04146 | 1.23817018 |
| 37 | Phototransduction_Homo sapiens_hsa04744 | 1.22772491 |
| 38 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.15769631 |
| 39 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.15478832 |
| 40 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.12237242 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11484732 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.10374344 |
| 43 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08026999 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.04567620 |
| 45 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.01542801 |
| 46 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.00394328 |
| 47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.98957916 |
| 48 | Basal transcription factors_Homo sapiens_hsa03022 | 0.96442112 |
| 49 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.93609036 |
| 50 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.91537998 |
| 51 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.89212088 |
| 52 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.82909572 |
| 53 | Other glycan degradation_Homo sapiens_hsa00511 | 0.78806534 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.77164058 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76881318 |
| 56 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.72271852 |
| 57 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.68242838 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.67717576 |
| 59 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67204830 |
| 60 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.66142484 |
| 61 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.60774666 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.59807761 |
| 63 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.58833280 |
| 64 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58574214 |
| 65 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.57814895 |
| 66 | Cell cycle_Homo sapiens_hsa04110 | 0.53705028 |
| 67 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.53289725 |
| 68 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51198988 |
| 69 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.48393605 |
| 70 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47378283 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44873479 |
| 72 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.42642737 |
| 73 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.41330638 |
| 74 | Lysine degradation_Homo sapiens_hsa00310 | 0.40945656 |
| 75 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.40936400 |
| 76 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.40798754 |
| 77 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39689821 |
| 78 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37704872 |
| 79 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.36886861 |
| 80 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36626605 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.35429105 |
| 82 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.35067987 |
| 83 | Carbon metabolism_Homo sapiens_hsa01200 | 0.34808398 |
| 84 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.34741205 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34524947 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.33098342 |
| 87 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.30555516 |
| 88 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.29125072 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27812436 |
| 90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.24755744 |
| 91 | Thyroid cancer_Homo sapiens_hsa05216 | 0.24028899 |
| 92 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.23384756 |
| 93 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.20924951 |
| 94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.20295897 |
| 95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.16230067 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.14990644 |
| 97 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.14475839 |
| 98 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.13178919 |
| 99 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.10152844 |
| 100 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.07669531 |

