

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 6.30795333 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.09776917 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.89948682 |
| 4 | synaptic vesicle exocytosis (GO:0016079) | 5.50303678 |
| 5 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.33254341 |
| 6 | locomotory exploration behavior (GO:0035641) | 5.25368076 |
| 7 | glutamate secretion (GO:0014047) | 5.02834599 |
| 8 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.73511342 |
| 9 | layer formation in cerebral cortex (GO:0021819) | 4.68211228 |
| 10 | regulation of synaptic vesicle transport (GO:1902803) | 4.67623419 |
| 11 | neurotransmitter secretion (GO:0007269) | 4.60056616 |
| 12 | response to pheromone (GO:0019236) | 4.58863188 |
| 13 | vocalization behavior (GO:0071625) | 4.47119663 |
| 14 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.43881428 |
| 15 | exploration behavior (GO:0035640) | 4.42563829 |
| 16 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.40965905 |
| 17 | neuron cell-cell adhesion (GO:0007158) | 4.37968625 |
| 18 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 4.31342142 |
| 19 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.26366042 |
| 20 | protein localization to synapse (GO:0035418) | 4.23887968 |
| 21 | COPII vesicle coating (GO:0048208) | 4.20353175 |
| 22 | regulation of synapse structural plasticity (GO:0051823) | 4.13367759 |
| 23 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.05725564 |
| 24 | proline transport (GO:0015824) | 4.05454728 |
| 25 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.92945725 |
| 26 | activation of protein kinase A activity (GO:0034199) | 3.86641963 |
| 27 | protein retention in ER lumen (GO:0006621) | 3.84773658 |
| 28 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.84499767 |
| 29 | axonal fasciculation (GO:0007413) | 3.75705399 |
| 30 | cell communication by electrical coupling (GO:0010644) | 3.74628291 |
| 31 | neuron recognition (GO:0008038) | 3.69535903 |
| 32 | regulation of vitamin metabolic process (GO:0030656) | 3.67853705 |
| 33 | sodium ion export (GO:0071436) | 3.67793411 |
| 34 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.65910877 |
| 35 | cerebellar Purkinje cell layer development (GO:0021680) | 3.60064078 |
| 36 | negative regulation of microtubule polymerization (GO:0031115) | 3.60052417 |
| 37 | positive regulation of synapse maturation (GO:0090129) | 3.59427460 |
| 38 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.58504096 |
| 39 | neurotransmitter transport (GO:0006836) | 3.57590997 |
| 40 | neuromuscular process controlling posture (GO:0050884) | 3.56326348 |
| 41 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.56276150 |
| 42 | cell migration in hindbrain (GO:0021535) | 3.56269124 |
| 43 | neuronal action potential propagation (GO:0019227) | 3.55754363 |
| 44 | dendrite morphogenesis (GO:0048813) | 3.54430648 |
| 45 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.54058978 |
| 46 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.53628998 |
| 47 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.52818224 |
| 48 | gamma-aminobutyric acid transport (GO:0015812) | 3.51840890 |
| 49 | cellular potassium ion homeostasis (GO:0030007) | 3.51607829 |
| 50 | innervation (GO:0060384) | 3.49603033 |
| 51 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.49325373 |
| 52 | oligosaccharide catabolic process (GO:0009313) | 3.48074728 |
| 53 | synaptic transmission, glutamatergic (GO:0035249) | 3.46494352 |
| 54 | dendritic spine morphogenesis (GO:0060997) | 3.44514149 |
| 55 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.43602515 |
| 56 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.39085012 |
| 57 | postsynaptic membrane organization (GO:0001941) | 3.35975817 |
| 58 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.35033149 |
| 59 | synaptic vesicle endocytosis (GO:0048488) | 3.35021698 |
| 60 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 3.33195802 |
| 61 | regulation of neurotransmitter levels (GO:0001505) | 3.32006836 |
| 62 | neuron-neuron synaptic transmission (GO:0007270) | 3.27166984 |
| 63 | regulation of neurotransmitter secretion (GO:0046928) | 3.22746968 |
| 64 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.20275136 |
| 65 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.20245247 |
| 66 | cell adhesion mediated by integrin (GO:0033627) | 3.18757422 |
| 67 | long-term memory (GO:0007616) | 3.17245896 |
| 68 | axon cargo transport (GO:0008088) | 3.16687845 |
| 69 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.16540776 |
| 70 | protein localization to endosome (GO:0036010) | 3.14815863 |
| 71 | response to auditory stimulus (GO:0010996) | 3.11558818 |
| 72 | organelle transport along microtubule (GO:0072384) | 3.11407546 |
| 73 | positive regulation of membrane potential (GO:0045838) | 3.11337195 |
| 74 | positive regulation of nuclease activity (GO:0032075) | 3.10804919 |
| 75 | neuronal ion channel clustering (GO:0045161) | 3.10149736 |
| 76 | vesicle transport along microtubule (GO:0047496) | 3.09111892 |
| 77 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.08227168 |
| 78 | regulation of vesicle fusion (GO:0031338) | 3.07848995 |
| 79 | glutamate receptor signaling pathway (GO:0007215) | 3.07437864 |
| 80 | NIK/NF-kappaB signaling (GO:0038061) | 3.06924369 |
| 81 | neuromuscular process controlling balance (GO:0050885) | 3.06491244 |
| 82 | ER overload response (GO:0006983) | 3.06413286 |
| 83 | auditory behavior (GO:0031223) | 3.03980936 |
| 84 | regulation of synaptic plasticity (GO:0048167) | 3.02790838 |
| 85 | regulation of neurotransmitter transport (GO:0051588) | 3.02002985 |
| 86 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.01338465 |
| 87 | endoplasmic reticulum unfolded protein response (GO:0030968) | 3.01186272 |
| 88 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.99756527 |
| 89 | establishment of synaptic vesicle localization (GO:0097480) | 2.99399915 |
| 90 | synaptic vesicle transport (GO:0048489) | 2.99399915 |
| 91 | synapse assembly (GO:0007416) | 2.98808250 |
| 92 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.98778031 |
| 93 | COPI coating of Golgi vesicle (GO:0048205) | 2.95970406 |
| 94 | Golgi transport vesicle coating (GO:0048200) | 2.95970406 |
| 95 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.94043022 |
| 96 | nucleobase catabolic process (GO:0046113) | 2.93125185 |
| 97 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.92040541 |
| 98 | clathrin coat assembly (GO:0048268) | 2.91531047 |
| 99 | cerebellum development (GO:0021549) | 2.91211036 |
| 100 | regulation of nuclease activity (GO:0032069) | 2.90536444 |
| 101 | hyaluronan catabolic process (GO:0030214) | 2.89009698 |
| 102 | ER-nucleus signaling pathway (GO:0006984) | 2.87798615 |
| 103 | regulation of respiratory system process (GO:0044065) | 2.87691918 |
| 104 | dopamine receptor signaling pathway (GO:0007212) | 2.87282585 |
| 105 | skin morphogenesis (GO:0043589) | 2.87213079 |
| 106 | signal release (GO:0023061) | 2.85612775 |
| 107 | long-term synaptic potentiation (GO:0060291) | 2.84388227 |
| 108 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.83086332 |
| 109 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.82845317 |
| 110 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.82565107 |
| 111 | regulation of postsynaptic membrane potential (GO:0060078) | 2.82563476 |
| 112 | vesicle coating (GO:0006901) | 2.81944907 |
| 113 | establishment of vesicle localization (GO:0051650) | 2.81554367 |
| 114 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.81454399 |
| 115 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.80950119 |
| 116 | membrane depolarization during action potential (GO:0086010) | 2.80907964 |
| 117 | glycine transport (GO:0015816) | 2.80680505 |
| 118 | glycolipid catabolic process (GO:0019377) | 2.79254872 |
| 119 | cellular response to unfolded protein (GO:0034620) | 2.79156235 |
| 120 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.78787762 |
| 121 | neuromuscular synaptic transmission (GO:0007274) | 2.78784030 |
| 122 | synapse organization (GO:0050808) | 2.78783720 |
| 123 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.78055931 |
| 124 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.76937682 |
| 125 | GDP-mannose metabolic process (GO:0019673) | 2.76544657 |
| 126 | positive regulation of neurotransmitter transport (GO:0051590) | 2.76520585 |
| 127 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.75450437 |
| 128 | glycosphingolipid catabolic process (GO:0046479) | 2.74310513 |
| 129 | pinocytosis (GO:0006907) | 2.73847525 |
| 130 | wound healing, spreading of epidermal cells (GO:0035313) | 2.67929384 |
| 131 | cellular response to arsenic-containing substance (GO:0071243) | 2.67820909 |
| 132 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.65562367 |
| 133 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.62563676 |
| 134 | protein maturation by protein folding (GO:0022417) | 2.62297392 |
| 135 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.59740560 |
| 136 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.58270767 |
| 137 | negative regulation of protein localization to plasma membrane (GO:1903077) | 2.54238174 |
| 138 | sphingosine metabolic process (GO:0006670) | 2.53117996 |
| 139 | cellular response to topologically incorrect protein (GO:0035967) | 2.52160158 |
| 140 | membrane lipid catabolic process (GO:0046466) | 2.49870260 |
| 141 | hemidesmosome assembly (GO:0031581) | 2.49704188 |
| 142 | low-density lipoprotein particle clearance (GO:0034383) | 2.49614853 |
| 143 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.48620989 |
| 144 | response to arsenic-containing substance (GO:0046685) | 2.45843086 |
| 145 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.44189213 |
| 146 | response to peptidoglycan (GO:0032494) | 2.42273837 |
| 147 | regulation of podosome assembly (GO:0071801) | 2.40059072 |
| 148 | amyloid precursor protein catabolic process (GO:0042987) | 2.39934216 |
| 149 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.38572366 |
| 150 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.36850587 |
| 151 | regulation of RIG-I signaling pathway (GO:0039535) | 2.35329693 |
| 152 | protein hydroxylation (GO:0018126) | 2.32537009 |
| 153 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.30829039 |
| 154 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.30736218 |
| 155 | regulation of transforming growth factor beta1 production (GO:0032908) | 2.30197910 |
| 156 | regulation of metalloenzyme activity (GO:0048552) | 2.30155145 |
| 157 | myeloid dendritic cell differentiation (GO:0043011) | 2.29629404 |
| 158 | negative regulation of establishment of protein localization to plasma membrane (GO:0090005) | 2.28801310 |
| 159 | response to endoplasmic reticulum stress (GO:0034976) | 2.27449680 |
| 160 | * peptidyl-asparagine modification (GO:0018196) | 2.26898019 |
| 161 | * protein N-linked glycosylation via asparagine (GO:0018279) | 2.25670873 |
| 162 | response to unfolded protein (GO:0006986) | 2.25525421 |
| 163 | ER to Golgi vesicle-mediated transport (GO:0006888) | 2.24648823 |
| 164 | sphingolipid catabolic process (GO:0030149) | 2.23828486 |
| 165 | regulation of fever generation (GO:0031620) | 2.23489390 |
| 166 | fibrinolysis (GO:0042730) | 2.23444356 |
| 167 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.21329068 |
| 168 | mitotic nuclear envelope reassembly (GO:0007084) | 2.20341012 |
| 169 | nuclear envelope reassembly (GO:0031468) | 2.20341012 |
| 170 | ceramide catabolic process (GO:0046514) | 2.19492941 |
| 171 | type I interferon signaling pathway (GO:0060337) | 2.16310239 |
| 172 | cellular response to type I interferon (GO:0071357) | 2.16310239 |
| 173 | ribosome assembly (GO:0042255) | 2.16242195 |
| 174 | serine transport (GO:0032329) | 2.16133430 |
| 175 | decidualization (GO:0046697) | 2.14356414 |
| 176 | wound healing, spreading of cells (GO:0044319) | 2.13537103 |
| 177 | regulation of chemokine biosynthetic process (GO:0045073) | 2.13160503 |
| 178 | regulation of response to interferon-gamma (GO:0060330) | 2.11241391 |
| 179 | regulation of immunoglobulin secretion (GO:0051023) | 2.11066831 |
| 180 | hyaluronan metabolic process (GO:0030212) | 2.11018132 |
| 181 | endoplasmic reticulum calcium ion homeostasis (GO:0032469) | 2.10250905 |
| 182 | peptide catabolic process (GO:0043171) | 2.10223179 |
| 183 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.10125248 |
| 184 | peptidyl-proline hydroxylation (GO:0019511) | 2.09413612 |
| 185 | * protein N-linked glycosylation (GO:0006487) | 2.08499312 |
| 186 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.08449792 |
| 187 | cellular copper ion homeostasis (GO:0006878) | 2.08363635 |
| 188 | response to type I interferon (GO:0034340) | 2.07829861 |
| 189 | establishment of viral latency (GO:0019043) | 2.07671049 |
| 190 | regulation of mononuclear cell migration (GO:0071675) | 2.07112132 |
| 191 | glycoside metabolic process (GO:0016137) | 2.07049850 |
| 192 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.06911207 |
| 193 | dendritic cell differentiation (GO:0097028) | 2.06506254 |
| 194 | response to topologically incorrect protein (GO:0035966) | 2.06420157 |
| 195 | positive regulation of extracellular matrix organization (GO:1903055) | 2.05520154 |
| 196 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.05463548 |
| 197 | natural killer cell mediated immunity (GO:0002228) | 2.05463548 |
| 198 | regulation of early endosome to late endosome transport (GO:2000641) | 2.03807375 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.86935422 |
| 2 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.89314065 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.11371262 |
| 4 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 3.10408224 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.09696522 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.09675522 |
| 7 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.03743251 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.94166541 |
| 9 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.92279525 |
| 10 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.82802176 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.74397498 |
| 12 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.72509033 |
| 13 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.72103732 |
| 14 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.65957409 |
| 15 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.65957409 |
| 16 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.62574136 |
| 17 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.62138780 |
| 18 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.61032242 |
| 19 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.60637745 |
| 20 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.59916611 |
| 21 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.54507607 |
| 22 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.52753382 |
| 23 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.46709862 |
| 24 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.43199722 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.38971387 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.38267356 |
| 27 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.38033424 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.33902783 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.32499024 |
| 30 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.31301423 |
| 31 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.28814664 |
| 32 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.26475653 |
| 33 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.26013901 |
| 34 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.25182577 |
| 35 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.18033472 |
| 36 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.17328677 |
| 37 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.13532321 |
| 38 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.11597433 |
| 39 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.10276807 |
| 40 | TFEB_21752829_ChIP-Seq_HELA_Human | 2.03948916 |
| 41 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.03302989 |
| 42 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.00643972 |
| 43 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.00170556 |
| 44 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.00049694 |
| 45 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.99133310 |
| 46 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.96507427 |
| 47 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.91536294 |
| 48 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.90825451 |
| 49 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.89469220 |
| 50 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.88335084 |
| 51 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.84328635 |
| 52 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.81443519 |
| 53 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.80694147 |
| 54 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.76547714 |
| 55 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.74391800 |
| 56 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.73174765 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.72138414 |
| 58 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.72080709 |
| 59 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.71519239 |
| 60 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.70036944 |
| 61 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.69281971 |
| 62 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.69159919 |
| 63 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.68671725 |
| 64 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.67794763 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.60242123 |
| 66 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.58899979 |
| 67 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.58478867 |
| 68 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.54950755 |
| 69 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.54200395 |
| 70 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.53946608 |
| 71 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.53267291 |
| 72 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.52604900 |
| 73 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.52017497 |
| 74 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.51809137 |
| 75 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.51686036 |
| 76 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.47946158 |
| 77 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.47667714 |
| 78 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.47210553 |
| 79 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.45509643 |
| 80 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.44776192 |
| 81 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.43429698 |
| 82 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.43209234 |
| 83 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.43130267 |
| 84 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.43057342 |
| 85 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.43014827 |
| 86 | ATF3_27146783_Chip-Seq_COLON_Human | 1.42745915 |
| 87 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.42648343 |
| 88 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.42648343 |
| 89 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.40740145 |
| 90 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.40711546 |
| 91 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.39865542 |
| 92 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.38740816 |
| 93 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.38602956 |
| 94 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.38588379 |
| 95 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.38579241 |
| 96 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.37657083 |
| 97 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.37408190 |
| 98 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.35638672 |
| 99 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.34114857 |
| 100 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.33751454 |
| 101 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.33525002 |
| 102 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.33049593 |
| 103 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.31802088 |
| 104 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.31471695 |
| 105 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.30577845 |
| 106 | AR_19668381_ChIP-Seq_PC3_Human | 1.28962272 |
| 107 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27186386 |
| 108 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.26747506 |
| 109 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.26490715 |
| 110 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.25874515 |
| 111 | KDM2B_26808549_Chip-Seq_K562_Human | 1.25355021 |
| 112 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.24589239 |
| 113 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.24170244 |
| 114 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.24069067 |
| 115 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.23348925 |
| 116 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.22738370 |
| 117 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.22593751 |
| 118 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22492646 |
| 119 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.21746372 |
| 120 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.21649499 |
| 121 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21601419 |
| 122 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.21176280 |
| 123 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.21094386 |
| 124 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20422609 |
| 125 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.19088017 |
| 126 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.18903423 |
| 127 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.18624084 |
| 128 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.18584212 |
| 129 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.18406046 |
| 130 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.18289843 |
| 131 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.16605214 |
| 132 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.16453226 |
| 133 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.16410822 |
| 134 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.15784094 |
| 135 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.14837496 |
| 136 | AR_25329375_ChIP-Seq_VCAP_Human | 1.14761908 |
| 137 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.14142208 |
| 138 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.13720813 |
| 139 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.12988511 |
| 140 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.12833154 |
| 141 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.12604395 |
| 142 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.12122841 |
| 143 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12116302 |
| 144 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.11732409 |
| 145 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.11677659 |
| 146 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.11041796 |
| 147 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.10970590 |
| 148 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.10802709 |
| 149 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.10554219 |
| 150 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.09369357 |
| 151 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.09279765 |
| 152 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.09111111 |
| 153 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08448395 |
| 154 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.07515867 |
| 155 | STAT3_23295773_ChIP-Seq_U87_Human | 1.07261022 |
| 156 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.06902019 |
| 157 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.06596350 |
| 158 | * NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.06088620 |
| 159 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.05852039 |
| 160 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.05204525 |
| 161 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.05099814 |
| 162 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04454182 |
| 163 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.04257293 |
| 164 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.04174796 |
| 165 | P300_19829295_ChIP-Seq_ESCs_Human | 1.03972948 |
| 166 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.03949587 |
| 167 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.03478666 |
| 168 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.03208320 |
| 169 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.03088775 |
| 170 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.03072178 |
| 171 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.02700374 |
| 172 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.02358667 |
| 173 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.02152783 |
| 174 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.00688386 |
| 175 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.96840153 |
| 176 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.94347293 |
| 177 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.93222847 |
| 178 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92221824 |
| 179 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.91187979 |
| 180 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.88132847 |
| 181 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.87383764 |
| 182 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.87111950 |
| 183 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.86168467 |
| 184 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.85585205 |
| 185 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84836652 |
| 186 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.84406245 |
| 187 | TCF4_23295773_ChIP-Seq_U87_Human | 0.83913400 |
| 188 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.83423573 |
| 189 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82563801 |
| 190 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.81956748 |
| 191 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.81407875 |
| 192 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.79927734 |
| 193 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.78941104 |
| 194 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.78381394 |
| 195 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.77131101 |
| 196 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.76510315 |
| 197 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.75017823 |
| 198 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.74098749 |
| 199 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.73610260 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.65713752 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 3.72616395 |
| 3 | MP0004270_analgesia | 3.54552940 |
| 4 | MP0003880_abnormal_central_pattern | 3.53050281 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.33329930 |
| 6 | MP0009840_abnormal_foam_cell | 3.18600002 |
| 7 | MP0002063_abnormal_learning/memory/cond | 2.95236149 |
| 8 | MP0005058_abnormal_lysosome_morphology | 2.95000964 |
| 9 | MP0008438_abnormal_cutaneous_collagen | 2.93144777 |
| 10 | MP0005451_abnormal_body_composition | 2.91435752 |
| 11 | MP0003122_maternal_imprinting | 2.80755867 |
| 12 | MP0010234_abnormal_vibrissa_follicle | 2.80178867 |
| 13 | MP0002139_abnormal_hepatobiliary_system | 2.74150714 |
| 14 | MP0009745_abnormal_behavioral_response | 2.71694302 |
| 15 | MP0005257_abnormal_intraocular_pressure | 2.71451150 |
| 16 | MP0002064_seizures | 2.62785413 |
| 17 | MP0002909_abnormal_adrenal_gland | 2.60362807 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.59562794 |
| 19 | MP0009046_muscle_twitch | 2.55732213 |
| 20 | MP0003303_peritoneal_inflammation | 2.50654924 |
| 21 | MP0001968_abnormal_touch/_nociception | 2.48052180 |
| 22 | MP0010352_gastrointestinal_tract_polyps | 2.45157803 |
| 23 | MP0002572_abnormal_emotion/affect_behav | 2.45040141 |
| 24 | MP0009780_abnormal_chondrocyte_physiolo | 2.44841299 |
| 25 | MP0003300_gastrointestinal_ulcer | 2.35245596 |
| 26 | MP0003941_abnormal_skin_development | 2.31982778 |
| 27 | MP0002733_abnormal_thermal_nociception | 2.29090807 |
| 28 | MP0003191_abnormal_cellular_cholesterol | 2.29012879 |
| 29 | MP0006276_abnormal_autonomic_nervous | 2.27353883 |
| 30 | MP0004858_abnormal_nervous_system | 2.24613606 |
| 31 | MP0003566_abnormal_cell_adhesion | 2.17225118 |
| 32 | MP0005645_abnormal_hypothalamus_physiol | 2.13240967 |
| 33 | MP0002272_abnormal_nervous_system | 2.12309933 |
| 34 | MP0005646_abnormal_pituitary_gland | 2.09393193 |
| 35 | MP0002184_abnormal_innervation | 2.07141379 |
| 36 | MP0002735_abnormal_chemical_nociception | 2.03860236 |
| 37 | MP0001486_abnormal_startle_reflex | 2.03515503 |
| 38 | MP0000778_abnormal_nervous_system | 2.00228702 |
| 39 | MP0001970_abnormal_pain_threshold | 1.95200439 |
| 40 | MP0004811_abnormal_neuron_physiology | 1.94812673 |
| 41 | MP0003787_abnormal_imprinting | 1.93773815 |
| 42 | MP0002822_catalepsy | 1.90686212 |
| 43 | MP0003453_abnormal_keratinocyte_physiol | 1.90237373 |
| 44 | MP0003329_amyloid_beta_deposits | 1.87578786 |
| 45 | MP0003705_abnormal_hypodermis_morpholog | 1.87261796 |
| 46 | MP0002877_abnormal_melanocyte_morpholog | 1.85055990 |
| 47 | MP0000955_abnormal_spinal_cord | 1.84431288 |
| 48 | MP0003436_decreased_susceptibility_to | 1.84084716 |
| 49 | MP0002557_abnormal_social/conspecific_i | 1.79872656 |
| 50 | MP0001501_abnormal_sleep_pattern | 1.75533784 |
| 51 | MP0008569_lethality_at_weaning | 1.73316146 |
| 52 | MP0002067_abnormal_sensory_capabilities | 1.72108459 |
| 53 | MP0006054_spinal_hemorrhage | 1.71330907 |
| 54 | MP0003091_abnormal_cell_migration | 1.70878196 |
| 55 | MP0008260_abnormal_autophagy | 1.69151946 |
| 56 | MP0001440_abnormal_grooming_behavior | 1.68060769 |
| 57 | MP0002736_abnormal_nociception_after | 1.66723008 |
| 58 | MP0003283_abnormal_digestive_organ | 1.65353816 |
| 59 | MP0002796_impaired_skin_barrier | 1.64631422 |
| 60 | MP0005386_behavior/neurological_phenoty | 1.61563284 |
| 61 | MP0004924_abnormal_behavior | 1.61563284 |
| 62 | MP0009785_altered_susceptibility_to | 1.60130141 |
| 63 | MP0002254_reproductive_system_inflammat | 1.58289648 |
| 64 | MP0001984_abnormal_olfaction | 1.54215088 |
| 65 | MP0008004_abnormal_stomach_pH | 1.52773831 |
| 66 | MP0002882_abnormal_neuron_morphology | 1.52735889 |
| 67 | MP0004272_abnormal_basement_membrane | 1.52237091 |
| 68 | MP0006082_CNS_inflammation | 1.52091696 |
| 69 | MP0005023_abnormal_wound_healing | 1.48300808 |
| 70 | MP0000013_abnormal_adipose_tissue | 1.47054084 |
| 71 | MP0004885_abnormal_endolymph | 1.45481588 |
| 72 | MP0001502_abnormal_circadian_rhythm | 1.44172922 |
| 73 | MP0000858_altered_metastatic_potential | 1.41617886 |
| 74 | MP0002148_abnormal_hypersensitivity_rea | 1.34878658 |
| 75 | MP0003879_abnormal_hair_cell | 1.34649823 |
| 76 | MP0002066_abnormal_motor_capabilities/c | 1.34197411 |
| 77 | MP0003656_abnormal_erythrocyte_physiolo | 1.33954148 |
| 78 | MP0005076_abnormal_cell_differentiation | 1.32923244 |
| 79 | MP0002060_abnormal_skin_morphology | 1.32676871 |
| 80 | MP0010386_abnormal_urinary_bladder | 1.30887553 |
| 81 | MP0003123_paternal_imprinting | 1.30705542 |
| 82 | MP0002638_abnormal_pupillary_reflex | 1.30055133 |
| 83 | MP0000569_abnormal_digit_pigmentation | 1.28109785 |
| 84 | MP0000631_abnormal_neuroendocrine_gland | 1.27888457 |
| 85 | MP0004947_skin_inflammation | 1.25837659 |
| 86 | MP0005275_abnormal_skin_tensile | 1.25382859 |
| 87 | MP0003183_abnormal_peptide_metabolism | 1.24751598 |
| 88 | MP0003121_genomic_imprinting | 1.24680830 |
| 89 | MP0008961_abnormal_basal_metabolism | 1.24601945 |
| 90 | MP0004510_myositis | 1.24493798 |
| 91 | MP0002152_abnormal_brain_morphology | 1.20732345 |
| 92 | MP0005000_abnormal_immune_tolerance | 1.20693189 |
| 93 | MP0001727_abnormal_embryo_implantation | 1.20572252 |
| 94 | MP0003950_abnormal_plasma_membrane | 1.19814780 |
| 95 | MP0003075_altered_response_to | 1.19322979 |
| 96 | MP0009333_abnormal_splenocyte_physiolog | 1.18805105 |
| 97 | MP0004142_abnormal_muscle_tone | 1.17994332 |
| 98 | MP0003172_abnormal_lysosome_physiology | 1.16978491 |
| 99 | MP0009697_abnormal_copulation | 1.15257031 |
| 100 | MP0005165_increased_susceptibility_to | 1.15146117 |
| 101 | MP0001216_abnormal_epidermal_layer | 1.14577721 |
| 102 | MP0004233_abnormal_muscle_weight | 1.14335510 |
| 103 | MP0005501_abnormal_skin_physiology | 1.14210371 |
| 104 | MP0002653_abnormal_ependyma_morphology | 1.13794276 |
| 105 | MP0001529_abnormal_vocalization | 1.13372877 |
| 106 | MP0003868_abnormal_feces_composition | 1.13062209 |
| 107 | MP0003633_abnormal_nervous_system | 1.12615747 |
| 108 | MP0001533_abnormal_skeleton_physiology | 1.12578444 |
| 109 | MP0000343_altered_response_to | 1.12355906 |
| 110 | MP0001853_heart_inflammation | 1.11729399 |
| 111 | MP0003806_abnormal_nucleotide_metabolis | 1.08389091 |
| 112 | MP0002998_abnormal_bone_remodeling | 1.07817686 |
| 113 | MP0003221_abnormal_cardiomyocyte_apopto | 1.05921934 |
| 114 | MP0001905_abnormal_dopamine_level | 1.05638757 |
| 115 | MP0010155_abnormal_intestine_physiology | 1.04460630 |
| 116 | MP0006072_abnormal_retinal_apoptosis | 1.03658417 |
| 117 | MP0001845_abnormal_inflammatory_respons | 1.03445674 |
| 118 | MP0008469_abnormal_protein_level | 1.02803196 |
| 119 | MP0001666_abnormal_nutrient_absorption | 1.02711472 |
| 120 | MP0001835_abnormal_antigen_presentation | 1.02671037 |
| 121 | MP0001542_abnormal_bone_strength | 1.02206445 |
| 122 | MP0002419_abnormal_innate_immunity | 1.01144021 |
| 123 | MP0005365_abnormal_bile_salt | 1.00666668 |
| 124 | MP0003448_altered_tumor_morphology | 1.00283467 |
| 125 | MP0005360_urolithiasis | 0.99600904 |
| 126 | MP0002069_abnormal_eating/drinking_beha | 0.98587318 |
| 127 | MP0001790_abnormal_immune_system | 0.97783376 |
| 128 | MP0005387_immune_system_phenotype | 0.97783376 |
| 129 | MP0002229_neurodegeneration | 0.97071017 |
| 130 | MP0002751_abnormal_autonomic_nervous | 0.97065242 |
| 131 | MP0001661_extended_life_span | 0.96956777 |
| 132 | MP0005621_abnormal_cell_physiology | 0.96278593 |
| 133 | MP0005394_taste/olfaction_phenotype | 0.96204383 |
| 134 | MP0005499_abnormal_olfactory_system | 0.96204383 |
| 135 | MP0005164_abnormal_response_to | 0.93775503 |
| 136 | MP0000685_abnormal_immune_system | 0.93754666 |
| 137 | MP0005551_abnormal_eye_electrophysiolog | 0.93734805 |
| 138 | MP0003634_abnormal_glial_cell | 0.93516251 |
| 139 | MP0003631_nervous_system_phenotype | 0.93115172 |
| 140 | MP0002332_abnormal_exercise_endurance | 0.93057318 |
| 141 | MP0003186_abnormal_redox_activity | 0.93050519 |
| 142 | MP0004185_abnormal_adipocyte_glucose | 0.92528803 |
| 143 | MP0001915_intracranial_hemorrhage | 0.91474952 |
| 144 | MP0002896_abnormal_bone_mineralization | 0.91251938 |
| 145 | MP0005025_abnormal_response_to | 0.91128203 |
| 146 | MP0004782_abnormal_surfactant_physiolog | 0.90795667 |
| 147 | MP0002452_abnormal_antigen_presenting | 0.90295118 |
| 148 | MP0004957_abnormal_blastocyst_morpholog | 0.90196657 |
| 149 | MP0001188_hyperpigmentation | 0.89970483 |
| 150 | MP0001730_embryonic_growth_arrest | 0.89624711 |
| 151 | MP0005187_abnormal_penis_morphology | 0.87711419 |
| 152 | MP0000751_myopathy | 0.87464700 |
| 153 | MP0004264_abnormal_extraembryonic_tissu | 0.86826316 |
| 154 | MP0003279_aneurysm | 0.86640704 |
| 155 | MP0009764_decreased_sensitivity_to | 0.86075475 |
| 156 | MP0004043_abnormal_pH_regulation | 0.85913871 |
| 157 | MP0001299_abnormal_eye_distance/ | 0.85688897 |
| 158 | MP0005623_abnormal_meninges_morphology | 0.84768970 |
| 159 | MP0000609_abnormal_liver_physiology | 0.83025802 |
| 160 | MP0000767_abnormal_smooth_muscle | 0.82587940 |
| 161 | MP0003195_calcinosis | 0.82236798 |
| 162 | MP0002752_abnormal_somatic_nervous | 0.81749583 |
| 163 | MP0003828_pulmonary_edema | 0.80585237 |
| 164 | MP0001243_abnormal_dermal_layer | 0.80306179 |
| 165 | MP0002089_abnormal_postnatal_growth/wei | 0.80237496 |
| 166 | MP0001348_abnormal_lacrimal_gland | 0.80235851 |
| 167 | MP0001944_abnormal_pancreas_morphology | 0.79427860 |
| 168 | MP0003693_abnormal_embryo_hatching | 0.79240360 |
| 169 | MP0002723_abnormal_immune_serum | 0.77167412 |
| 170 | MP0003795_abnormal_bone_structure | 0.77053172 |
| 171 | MP0005384_cellular_phenotype | 0.76906312 |
| 172 | MP0003861_abnormal_nervous_system | 0.76337027 |
| 173 | MP0005535_abnormal_body_temperature | 0.74313978 |
| 174 | MP0001849_ear_inflammation | 0.73838587 |
| 175 | MP0005464_abnormal_platelet_physiology | 0.73693591 |
| 176 | MP0008007_abnormal_cellular_replicative | 0.73640276 |
| 177 | MP0002006_tumorigenesis | 0.73178502 |
| 178 | MP0000490_abnormal_crypts_of | 0.72581845 |
| 179 | MP0005166_decreased_susceptibility_to | 0.72534963 |
| 180 | MP0004085_abnormal_heartbeat | 0.71872489 |
| 181 | MP0005253_abnormal_eye_physiology | 0.70608415 |
| 182 | MP0002234_abnormal_pharynx_morphology | 0.70156943 |
| 183 | MP0004145_abnormal_muscle_electrophysio | 0.69991826 |
| 184 | MP0003632_abnormal_nervous_system | 0.69858866 |
| 185 | MP0002090_abnormal_vision | 0.69259724 |
| 186 | MP0000604_amyloidosis | 0.69072288 |
| 187 | MP0000534_abnormal_ureter_morphology | 0.68451430 |
| 188 | MP0001177_atelectasis | 0.66679552 |
| 189 | MP0000639_abnormal_adrenal_gland | 0.63220275 |
| 190 | MP0002693_abnormal_pancreas_physiology | 0.63107894 |
| 191 | MP0003119_abnormal_digestive_system | 0.63060630 |
| 192 | MP0001963_abnormal_hearing_physiology | 0.62622689 |
| 193 | MP0003953_abnormal_hormone_level | 0.62605592 |
| 194 | MP0001943_abnormal_respiration | 0.62354762 |
| 195 | MP0008872_abnormal_physiological_respon | 0.61448612 |
| 196 | MP0010769_abnormal_survival | 0.60982989 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.32735271 |
| 2 | Focal motor seizures (HP:0011153) | 4.98442335 |
| 3 | Visual hallucinations (HP:0002367) | 4.96850633 |
| 4 | Focal seizures (HP:0007359) | 4.21458225 |
| 5 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.95587638 |
| 6 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.95587638 |
| 7 | Abnormality of glycolipid metabolism (HP:0010969) | 3.95587638 |
| 8 | Ankle clonus (HP:0011448) | 3.89494616 |
| 9 | Epileptic encephalopathy (HP:0200134) | 3.82893990 |
| 10 | Supranuclear gaze palsy (HP:0000605) | 3.77158247 |
| 11 | Vacuolated lymphocytes (HP:0001922) | 3.68866114 |
| 12 | Premature rupture of membranes (HP:0001788) | 3.61350191 |
| 13 | Tetraparesis (HP:0002273) | 3.55509744 |
| 14 | Loss of speech (HP:0002371) | 3.55143856 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.52885167 |
| 16 | Agitation (HP:0000713) | 3.40214026 |
| 17 | Papilledema (HP:0001085) | 3.39585526 |
| 18 | Vertebral compression fractures (HP:0002953) | 3.36300712 |
| 19 | Pheochromocytoma (HP:0002666) | 3.32595615 |
| 20 | Depression (HP:0000716) | 3.29070866 |
| 21 | Mutism (HP:0002300) | 3.26269112 |
| 22 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 3.25842438 |
| 23 | Action tremor (HP:0002345) | 3.20928656 |
| 24 | Abnormal eating behavior (HP:0100738) | 3.18894511 |
| 25 | Atonic seizures (HP:0010819) | 3.17796518 |
| 26 | Dysostosis multiplex (HP:0000943) | 3.15174997 |
| 27 | Absence seizures (HP:0002121) | 3.04717771 |
| 28 | Febrile seizures (HP:0002373) | 2.99218344 |
| 29 | Polyphagia (HP:0002591) | 2.91943280 |
| 30 | Limb dystonia (HP:0002451) | 2.91628473 |
| 31 | Generalized tonic-clonic seizures (HP:0002069) | 2.86934572 |
| 32 | Neuroendocrine neoplasm (HP:0100634) | 2.86912241 |
| 33 | Failure to thrive in infancy (HP:0001531) | 2.83370106 |
| 34 | Truncal ataxia (HP:0002078) | 2.82013606 |
| 35 | EEG with generalized epileptiform discharges (HP:0011198) | 2.80369069 |
| 36 | Epileptiform EEG discharges (HP:0011182) | 2.76769646 |
| 37 | Hypsarrhythmia (HP:0002521) | 2.76577617 |
| 38 | Anxiety (HP:0000739) | 2.76240982 |
| 39 | Genetic anticipation (HP:0003743) | 2.70865861 |
| 40 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.68764100 |
| 41 | Mucopolysacchariduria (HP:0008155) | 2.68764100 |
| 42 | Dialeptic seizures (HP:0011146) | 2.68017368 |
| 43 | Insomnia (HP:0100785) | 2.62695248 |
| 44 | Poor eye contact (HP:0000817) | 2.62386669 |
| 45 | Postural instability (HP:0002172) | 2.62280626 |
| 46 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.60492374 |
| 47 | Amyotrophic lateral sclerosis (HP:0007354) | 2.60302186 |
| 48 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.59391499 |
| 49 | Atrophic scars (HP:0001075) | 2.58530139 |
| 50 | Abnormality of the lower motor neuron (HP:0002366) | 2.57561347 |
| 51 | Torticollis (HP:0000473) | 2.57206684 |
| 52 | Spastic gait (HP:0002064) | 2.56217645 |
| 53 | Megalencephaly (HP:0001355) | 2.55232390 |
| 54 | Urinary urgency (HP:0000012) | 2.54696241 |
| 55 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.52193983 |
| 56 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.52193983 |
| 57 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.52193983 |
| 58 | Abnormal tarsal ossification (HP:0008369) | 2.50485639 |
| 59 | Drooling (HP:0002307) | 2.50389129 |
| 60 | Excessive salivation (HP:0003781) | 2.50389129 |
| 61 | Systemic lupus erythematosus (HP:0002725) | 2.47824175 |
| 62 | Generalized aminoaciduria (HP:0002909) | 2.45750971 |
| 63 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.42289449 |
| 64 | Osteolytic defects of the hand bones (HP:0009699) | 2.42289449 |
| 65 | Protrusio acetabuli (HP:0003179) | 2.39429142 |
| 66 | Impaired social interactions (HP:0000735) | 2.39030640 |
| 67 | Abnormal social behavior (HP:0012433) | 2.39030640 |
| 68 | Abnormality of carpal bone ossification (HP:0006257) | 2.37611229 |
| 69 | Deep venous thrombosis (HP:0002625) | 2.36134555 |
| 70 | Myocardial infarction (HP:0001658) | 2.35664029 |
| 71 | Broad-based gait (HP:0002136) | 2.33898159 |
| 72 | Focal dystonia (HP:0004373) | 2.33203532 |
| 73 | Progressive neurologic deterioration (HP:0002344) | 2.32380840 |
| 74 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.31556573 |
| 75 | Hypoventilation (HP:0002791) | 2.29928024 |
| 76 | Bradykinesia (HP:0002067) | 2.29434872 |
| 77 | Impaired smooth pursuit (HP:0007772) | 2.27692584 |
| 78 | Increased serum pyruvate (HP:0003542) | 2.26784713 |
| 79 | Abnormality of macrophages (HP:0004311) | 2.26740933 |
| 80 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.25109760 |
| 81 | Hypercortisolism (HP:0001578) | 2.23768123 |
| 82 | Intrahepatic cholestasis (HP:0001406) | 2.21452359 |
| 83 | Menstrual irregularities (HP:0000858) | 2.20782632 |
| 84 | Neoplasm of the heart (HP:0100544) | 2.20096305 |
| 85 | Prolonged neonatal jaundice (HP:0006579) | 2.19791089 |
| 86 | Craniofacial dystonia (HP:0012179) | 2.19665038 |
| 87 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.19564429 |
| 88 | Clonus (HP:0002169) | 2.17273969 |
| 89 | Hyperacusis (HP:0010780) | 2.16972874 |
| 90 | Onycholysis (HP:0001806) | 2.16752090 |
| 91 | Abnormality of glycolysis (HP:0004366) | 2.16406312 |
| 92 | Macroorchidism (HP:0000053) | 2.16242529 |
| 93 | Steatorrhea (HP:0002570) | 2.15688814 |
| 94 | Lower limb muscle weakness (HP:0007340) | 2.14673157 |
| 95 | Dysdiadochokinesis (HP:0002075) | 2.14534694 |
| 96 | Symptomatic seizures (HP:0011145) | 2.14220120 |
| 97 | Amblyopia (HP:0000646) | 2.13274695 |
| 98 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.12862957 |
| 99 | Fat malabsorption (HP:0002630) | 2.12527691 |
| 100 | Nuclear cataract (HP:0100018) | 2.11790124 |
| 101 | Hemiparesis (HP:0001269) | 2.11121621 |
| 102 | IgA deficiency (HP:0002720) | 2.09966375 |
| 103 | Neurofibrillary tangles (HP:0002185) | 2.09317416 |
| 104 | Abnormality of the corticospinal tract (HP:0002492) | 2.08731880 |
| 105 | Akinesia (HP:0002304) | 2.07680726 |
| 106 | Dry hair (HP:0011359) | 2.07429598 |
| 107 | Poor suck (HP:0002033) | 2.05683904 |
| 108 | Stereotypic behavior (HP:0000733) | 2.05329759 |
| 109 | Abnormality of the Achilles tendon (HP:0005109) | 2.04888527 |
| 110 | Cerebral inclusion bodies (HP:0100314) | 2.04144183 |
| 111 | Exocrine pancreatic insufficiency (HP:0001738) | 2.03459457 |
| 112 | Hyperventilation (HP:0002883) | 2.03178769 |
| 113 | Diplopia (HP:0000651) | 2.02956261 |
| 114 | Abnormality of binocular vision (HP:0011514) | 2.02956261 |
| 115 | Reduced antithrombin III activity (HP:0001976) | 2.02932210 |
| 116 | Flat acetabular roof (HP:0003180) | 2.02426499 |
| 117 | Complement deficiency (HP:0004431) | 2.02023370 |
| 118 | Hypoplasia of the brainstem (HP:0002365) | 2.01198244 |
| 119 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.01198244 |
| 120 | Insidious onset (HP:0003587) | 2.00970473 |
| 121 | Termporal pattern (HP:0011008) | 2.00970473 |
| 122 | Progressive inability to walk (HP:0002505) | 1.99901426 |
| 123 | Lissencephaly (HP:0001339) | 1.99759747 |
| 124 | Achilles tendon contracture (HP:0001771) | 1.99672020 |
| 125 | Pointed chin (HP:0000307) | 1.98953294 |
| 126 | Glomerulonephritis (HP:0000099) | 1.97886586 |
| 127 | Abnormality of the intrinsic pathway (HP:0010989) | 1.97855346 |
| 128 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.97329734 |
| 129 | Increased cerebral lipofuscin (HP:0011813) | 1.96936492 |
| 130 | Cervical subluxation (HP:0003308) | 1.96703001 |
| 131 | Malnutrition (HP:0004395) | 1.96699211 |
| 132 | Elfin facies (HP:0004428) | 1.96473870 |
| 133 | Dysmetria (HP:0001310) | 1.95630497 |
| 134 | Interstitial pulmonary disease (HP:0006530) | 1.95355497 |
| 135 | Apathy (HP:0000741) | 1.95232569 |
| 136 | Abnormality of the costochondral junction (HP:0000919) | 1.95152484 |
| 137 | Gastrointestinal stroma tumor (HP:0100723) | 1.94843450 |
| 138 | Abnormality of complement system (HP:0005339) | 1.94731272 |
| 139 | Gaze-evoked nystagmus (HP:0000640) | 1.92908408 |
| 140 | Hemiplegia (HP:0002301) | 1.89098370 |
| 141 | Progressive hearing impairment (HP:0001730) | 1.88833017 |
| 142 | Abnormality of pain sensation (HP:0010832) | 1.87732049 |
| 143 | Impaired pain sensation (HP:0007328) | 1.87732049 |
| 144 | Abnormal trabecular bone morphology (HP:0100671) | 1.87721941 |
| 145 | Abnormal ossification of hand bones (HP:0005921) | 1.86875403 |
| 146 | Scanning speech (HP:0002168) | 1.86759553 |
| 147 | Bone pain (HP:0002653) | 1.86457472 |
| 148 | Restlessness (HP:0000711) | 1.86294136 |
| 149 | Short nail (HP:0001799) | 1.86012223 |
| 150 | Plantar hyperkeratosis (HP:0007556) | 1.85934951 |
| 151 | Hypobetalipoproteinemia (HP:0003563) | 1.85076661 |
| 152 | Diminished motivation (HP:0000745) | 1.85059668 |
| 153 | Natal tooth (HP:0000695) | 1.84949965 |
| 154 | Cardiovascular calcification (HP:0011915) | 1.84654757 |
| 155 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.83812116 |
| 156 | Hepatoblastoma (HP:0002884) | 1.83434628 |
| 157 | Abnormal foot bone ossification (HP:0010675) | 1.83335174 |
| 158 | Vascular calcification (HP:0004934) | 1.81626651 |
| 159 | Abnormal gallbladder physiology (HP:0012438) | 1.81043243 |
| 160 | Cholecystitis (HP:0001082) | 1.81043243 |
| 161 | Gait imbalance (HP:0002141) | 1.80784715 |
| 162 | Spinal canal stenosis (HP:0003416) | 1.80698794 |
| 163 | Fetal akinesia sequence (HP:0001989) | 1.80537180 |
| 164 | Alopecia of scalp (HP:0002293) | 1.79916393 |
| 165 | Open mouth (HP:0000194) | 1.79623662 |
| 166 | Elevated alkaline phosphatase (HP:0003155) | 1.79522371 |
| 167 | Generalized hypotonia (HP:0001290) | 1.79448628 |
| 168 | Distal upper limb amyotrophy (HP:0007149) | 1.79366942 |
| 169 | Upper limb amyotrophy (HP:0009129) | 1.79366942 |
| 170 | Upper motor neuron abnormality (HP:0002127) | 1.79236939 |
| 171 | Rough bone trabeculation (HP:0100670) | 1.78682480 |
| 172 | Hand muscle atrophy (HP:0009130) | 1.78537885 |
| 173 | Rigidity (HP:0002063) | 1.78109505 |
| 174 | Muscular hypotonia of the trunk (HP:0008936) | 1.77417986 |
| 175 | Specific learning disability (HP:0001328) | 1.77390844 |
| 176 | Shoulder girdle muscle weakness (HP:0003547) | 1.76904226 |
| 177 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.75538076 |
| 178 | Spondylolisthesis (HP:0003302) | 1.73140537 |
| 179 | Metaphyseal irregularity (HP:0003025) | 1.72436973 |
| 180 | Fragile skin (HP:0001030) | 1.71729531 |
| 181 | Disinhibition (HP:0000734) | 1.71647380 |
| 182 | Upper limb muscle weakness (HP:0003484) | 1.71611107 |
| 183 | Axonal loss (HP:0003447) | 1.71151011 |
| 184 | Entropion (HP:0000621) | 1.69530033 |
| 185 | Hypokinesia (HP:0002375) | 1.67404482 |
| 186 | Type I transferrin isoform profile (HP:0003642) | 1.66693347 |
| 187 | Hypolipoproteinemia (HP:0010981) | 1.66512635 |
| 188 | Hyperparathyroidism (HP:0000843) | 1.66417981 |
| 189 | Fatigue (HP:0012378) | 1.64648479 |
| 190 | Nausea (HP:0002018) | 1.64162151 |
| 191 | Xanthomatosis (HP:0000991) | 1.63447642 |
| 192 | Amyloidosis (HP:0011034) | 1.62737924 |
| 193 | Multiple enchondromatosis (HP:0005701) | 1.62383539 |
| 194 | Abnormality of the acetabulum (HP:0003170) | 1.61581026 |
| 195 | Lower limb hyperreflexia (HP:0002395) | 1.61313317 |
| 196 | Beaking of vertebral bodies (HP:0004568) | 1.61299169 |
| 197 | Pelvic girdle muscle weakness (HP:0003749) | 1.59742070 |
| 198 | Blue sclerae (HP:0000592) | 1.59619775 |
| 199 | Abnormality of the common coagulation pathway (HP:0010990) | 1.59583309 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.96270839 |
| 2 | NTRK3 | 4.09050598 |
| 3 | IRAK3 | 3.92482793 |
| 4 | MAP3K9 | 3.73552579 |
| 5 | ERN1 | 3.32514996 |
| 6 | MAP3K4 | 3.01352341 |
| 7 | MINK1 | 2.97950934 |
| 8 | NME2 | 2.95876609 |
| 9 | NTRK2 | 2.55169642 |
| 10 | MAP2K7 | 2.45147907 |
| 11 | PIM2 | 2.34573003 |
| 12 | EIF2AK3 | 2.24646576 |
| 13 | PBK | 2.22145945 |
| 14 | PAK6 | 2.20078930 |
| 15 | EPHA2 | 2.16615851 |
| 16 | MST1R | 2.09143906 |
| 17 | MAP3K12 | 2.07017084 |
| 18 | CDK12 | 2.06808334 |
| 19 | NTRK1 | 2.05046762 |
| 20 | TAOK2 | 2.04942085 |
| 21 | PRKD3 | 2.04138271 |
| 22 | DDR2 | 2.02942208 |
| 23 | EPHA4 | 1.98752847 |
| 24 | TESK2 | 1.90439057 |
| 25 | KSR2 | 1.82643029 |
| 26 | MAP2K4 | 1.81794411 |
| 27 | TBK1 | 1.78223100 |
| 28 | KSR1 | 1.76814539 |
| 29 | MAPK13 | 1.75778869 |
| 30 | PAK4 | 1.73612429 |
| 31 | CAMKK1 | 1.70549658 |
| 32 | PHKG1 | 1.70277630 |
| 33 | PHKG2 | 1.70277630 |
| 34 | SCYL2 | 1.66845089 |
| 35 | MAP3K14 | 1.64458841 |
| 36 | DAPK2 | 1.63209298 |
| 37 | UHMK1 | 1.61163605 |
| 38 | CDK5 | 1.54729660 |
| 39 | MAP3K3 | 1.43301796 |
| 40 | CDK19 | 1.39232757 |
| 41 | TGFBR2 | 1.38340120 |
| 42 | CAMKK2 | 1.35726355 |
| 43 | DAPK1 | 1.28156068 |
| 44 | FGFR4 | 1.24781395 |
| 45 | CASK | 1.24196464 |
| 46 | MOS | 1.23834263 |
| 47 | MAP3K2 | 1.21874089 |
| 48 | ERBB3 | 1.20569435 |
| 49 | SIK1 | 1.20096657 |
| 50 | PRKCG | 1.20076667 |
| 51 | TNIK | 1.18993024 |
| 52 | FLT3 | 1.18677103 |
| 53 | ICK | 1.18450963 |
| 54 | PLK2 | 1.16073695 |
| 55 | LMTK2 | 1.15505413 |
| 56 | ERBB4 | 1.13422266 |
| 57 | BMPR2 | 1.12185477 |
| 58 | CSNK1G2 | 1.11962977 |
| 59 | PAK3 | 1.08963585 |
| 60 | TTK | 1.08543167 |
| 61 | CLK1 | 1.08026274 |
| 62 | STK24 | 1.07406351 |
| 63 | NEK1 | 1.05535201 |
| 64 | BCKDK | 1.05270802 |
| 65 | LIMK1 | 1.05116945 |
| 66 | LATS2 | 1.05054331 |
| 67 | NEK9 | 1.04352107 |
| 68 | DYRK2 | 1.03659314 |
| 69 | SIK2 | 1.03622279 |
| 70 | RET | 1.02963048 |
| 71 | GRK5 | 1.01946200 |
| 72 | CDK6 | 1.00928364 |
| 73 | WNK3 | 0.99822520 |
| 74 | SIK3 | 0.99248819 |
| 75 | SMG1 | 0.98904673 |
| 76 | CDK14 | 0.98708817 |
| 77 | TYK2 | 0.97256011 |
| 78 | CHUK | 0.96484027 |
| 79 | CDK18 | 0.96357577 |
| 80 | PKN2 | 0.95361558 |
| 81 | SGK223 | 0.93175086 |
| 82 | SGK494 | 0.93175086 |
| 83 | PTK2 | 0.91926447 |
| 84 | TAOK1 | 0.91882797 |
| 85 | CDK15 | 0.90967521 |
| 86 | EIF2AK1 | 0.89715196 |
| 87 | BUB1 | 0.88840934 |
| 88 | PRKCH | 0.88818658 |
| 89 | GRK7 | 0.88814969 |
| 90 | MAP3K5 | 0.87211828 |
| 91 | STK10 | 0.86325759 |
| 92 | ARAF | 0.86175096 |
| 93 | MATK | 0.85720750 |
| 94 | IKBKE | 0.84950863 |
| 95 | TYRO3 | 0.84066001 |
| 96 | DYRK1A | 0.83368389 |
| 97 | PRKG2 | 0.81642083 |
| 98 | STK38 | 0.80763358 |
| 99 | CDK11A | 0.79035755 |
| 100 | ABL2 | 0.78042732 |
| 101 | RPS6KA2 | 0.77825610 |
| 102 | TRPM7 | 0.77558641 |
| 103 | JAK3 | 0.77394666 |
| 104 | BRSK2 | 0.77035005 |
| 105 | IKBKB | 0.76279845 |
| 106 | PRPF4B | 0.75380193 |
| 107 | SRPK1 | 0.75173113 |
| 108 | ALK | 0.74541465 |
| 109 | BRSK1 | 0.74086233 |
| 110 | INSRR | 0.73519757 |
| 111 | TRIB3 | 0.73242832 |
| 112 | PDK2 | 0.73156615 |
| 113 | SGK2 | 0.73119778 |
| 114 | EPHA3 | 0.72548134 |
| 115 | RIPK1 | 0.71439769 |
| 116 | CSNK1G3 | 0.71395679 |
| 117 | CAMK1 | 0.70372931 |
| 118 | MARK2 | 0.70007875 |
| 119 | MYLK | 0.69719385 |
| 120 | CAMK2A | 0.66392134 |
| 121 | SGK3 | 0.65645949 |
| 122 | CDK8 | 0.65439501 |
| 123 | JAK1 | 0.64877485 |
| 124 | HIPK2 | 0.63909102 |
| 125 | CDC42BPA | 0.62874277 |
| 126 | CDK9 | 0.62058421 |
| 127 | MAP3K1 | 0.61595975 |
| 128 | CCNB1 | 0.60687676 |
| 129 | MET | 0.60416499 |
| 130 | STK16 | 0.60278531 |
| 131 | PRKCZ | 0.60261669 |
| 132 | ACVR1B | 0.59766406 |
| 133 | MAP3K8 | 0.58793220 |
| 134 | FES | 0.57731839 |
| 135 | MST4 | 0.56518503 |
| 136 | MAPK11 | 0.55229386 |
| 137 | RPS6KB2 | 0.55006465 |
| 138 | CAMK1G | 0.53022939 |
| 139 | FGFR3 | 0.51823157 |
| 140 | IRAK4 | 0.50665463 |
| 141 | PDGFRA | 0.49530584 |
| 142 | PRKD2 | 0.48873223 |
| 143 | STK3 | 0.47976673 |
| 144 | STK11 | 0.47893989 |
| 145 | PASK | 0.47741257 |
| 146 | RAF1 | 0.47569603 |
| 147 | FER | 0.47243329 |
| 148 | TESK1 | 0.47071262 |
| 149 | CDK7 | 0.46595815 |
| 150 | PNCK | 0.45953675 |
| 151 | IRAK2 | 0.45693662 |
| 152 | CSNK1A1L | 0.45039528 |
| 153 | LATS1 | 0.44815064 |
| 154 | PRKCE | 0.44758474 |
| 155 | PIM1 | 0.44306493 |
| 156 | MAP3K13 | 0.44077525 |
| 157 | BRD4 | 0.43824065 |
| 158 | CAMK2B | 0.43177902 |
| 159 | RPS6KA3 | 0.42590049 |
| 160 | PINK1 | 0.42102793 |
| 161 | SGK1 | 0.42099997 |
| 162 | MAPK10 | 0.41755688 |
| 163 | DYRK3 | 0.40349874 |
| 164 | MAP2K3 | 0.39721657 |
| 165 | DAPK3 | 0.39498591 |
| 166 | MELK | 0.38036432 |
| 167 | CSF1R | 0.37067974 |
| 168 | MAPK9 | 0.36991547 |
| 169 | MAP2K1 | 0.36784450 |
| 170 | ADRBK1 | 0.36122010 |
| 171 | BCR | 0.35929085 |
| 172 | BRAF | 0.34697933 |
| 173 | ERBB2 | 0.34252131 |
| 174 | AKT3 | 0.33646914 |
| 175 | MAP3K11 | 0.33485088 |
| 176 | EPHB1 | 0.33185226 |
| 177 | FYN | 0.32742574 |
| 178 | CSNK1G1 | 0.30733643 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.70214181 |
| 2 | Other glycan degradation_Homo sapiens_hsa00511 | 3.09769446 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 3.07397863 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.69891409 |
| 5 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.61001509 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.52815450 |
| 7 | Insulin secretion_Homo sapiens_hsa04911 | 2.49694843 |
| 8 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.45760164 |
| 9 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.32854845 |
| 10 | Olfactory transduction_Homo sapiens_hsa04740 | 2.32326258 |
| 11 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.31018568 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.29714124 |
| 13 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.28710491 |
| 14 | Long-term potentiation_Homo sapiens_hsa04720 | 2.25923254 |
| 15 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.25071855 |
| 16 | Morphine addiction_Homo sapiens_hsa05032 | 2.19196101 |
| 17 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.14228133 |
| 18 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.12061452 |
| 19 | Lysosome_Homo sapiens_hsa04142 | 2.06248645 |
| 20 | Cocaine addiction_Homo sapiens_hsa05030 | 1.99200017 |
| 21 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.97302721 |
| 22 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.96894852 |
| 23 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95601492 |
| 24 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.86380484 |
| 25 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.82077631 |
| 26 | Salivary secretion_Homo sapiens_hsa04970 | 1.68170808 |
| 27 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.63719099 |
| 28 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.62836101 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.60074648 |
| 30 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.59259720 |
| 31 | Taste transduction_Homo sapiens_hsa04742 | 1.58786184 |
| 32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.58260581 |
| 33 | Legionellosis_Homo sapiens_hsa05134 | 1.57161607 |
| 34 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.56213326 |
| 35 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.55958325 |
| 36 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.51633333 |
| 37 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.50633833 |
| 38 | Proteasome_Homo sapiens_hsa03050 | 1.49817575 |
| 39 | Protein export_Homo sapiens_hsa03060 | 1.47904159 |
| 40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.44949281 |
| 41 | Gap junction_Homo sapiens_hsa04540 | 1.44475567 |
| 42 | Renin secretion_Homo sapiens_hsa04924 | 1.44053638 |
| 43 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.42197948 |
| 44 | Long-term depression_Homo sapiens_hsa04730 | 1.42177445 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.38147853 |
| 46 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.35959293 |
| 47 | Bladder cancer_Homo sapiens_hsa05219 | 1.33595631 |
| 48 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.32830527 |
| 49 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.29706443 |
| 50 | Axon guidance_Homo sapiens_hsa04360 | 1.26242285 |
| 51 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.24705630 |
| 52 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.23526349 |
| 53 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.23387547 |
| 54 | Influenza A_Homo sapiens_hsa05164 | 1.22858824 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.22814875 |
| 56 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.21855637 |
| 57 | Galactose metabolism_Homo sapiens_hsa00052 | 1.20028414 |
| 58 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.19977369 |
| 59 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.19609100 |
| 60 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.18400706 |
| 61 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.13745679 |
| 62 | Shigellosis_Homo sapiens_hsa05131 | 1.13306027 |
| 63 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.11528961 |
| 64 | Pertussis_Homo sapiens_hsa05133 | 1.11356310 |
| 65 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.11010308 |
| 66 | Hepatitis C_Homo sapiens_hsa05160 | 1.10501272 |
| 67 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.09451719 |
| 68 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.09073183 |
| 69 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.09029986 |
| 70 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.08301811 |
| 71 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.07915119 |
| 72 | Glioma_Homo sapiens_hsa05214 | 1.07834179 |
| 73 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07424494 |
| 74 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.05545148 |
| 75 | Melanogenesis_Homo sapiens_hsa04916 | 1.03305683 |
| 76 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.02177260 |
| 77 | Leishmaniasis_Homo sapiens_hsa05140 | 1.01651723 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.00383094 |
| 79 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.99259971 |
| 80 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.98682602 |
| 81 | Salmonella infection_Homo sapiens_hsa05132 | 0.98225900 |
| 82 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.96879375 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.96203490 |
| 84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.95234626 |
| 85 | Apoptosis_Homo sapiens_hsa04210 | 0.95082077 |
| 86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.94987545 |
| 87 | Hepatitis B_Homo sapiens_hsa05161 | 0.94507258 |
| 88 | Phagosome_Homo sapiens_hsa04145 | 0.92954043 |
| 89 | Measles_Homo sapiens_hsa05162 | 0.92949738 |
| 90 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.92183447 |
| 91 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.91743076 |
| 92 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.91549457 |
| 93 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.89688125 |
| 94 | Allograft rejection_Homo sapiens_hsa05330 | 0.87962128 |
| 95 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87185367 |
| 96 | Endometrial cancer_Homo sapiens_hsa05213 | 0.87132281 |
| 97 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.86849598 |
| 98 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.86594996 |
| 99 | Carbon metabolism_Homo sapiens_hsa01200 | 0.85147167 |
| 100 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.83808033 |
| 101 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.83332576 |
| 102 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.83235578 |
| 103 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.78542321 |
| 104 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.78279002 |
| 105 | Alcoholism_Homo sapiens_hsa05034 | 0.77725567 |
| 106 | Tuberculosis_Homo sapiens_hsa05152 | 0.76675431 |
| 107 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.76219942 |
| 108 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.75719844 |
| 109 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.74577064 |
| 110 | Viral myocarditis_Homo sapiens_hsa05416 | 0.74202376 |
| 111 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.73987380 |
| 112 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.73678142 |
| 113 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.73371155 |
| 114 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.73182814 |
| 115 | Amoebiasis_Homo sapiens_hsa05146 | 0.72796594 |
| 116 | Colorectal cancer_Homo sapiens_hsa05210 | 0.72574639 |
| 117 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.72463149 |
| 118 | Malaria_Homo sapiens_hsa05144 | 0.70663713 |
| 119 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.70662644 |
| 120 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.70023893 |
| 121 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.69906471 |
| 122 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.69725278 |
| 123 | Circadian rhythm_Homo sapiens_hsa04710 | 0.69211267 |
| 124 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.68954138 |
| 125 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.68022346 |
| 126 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.67829094 |
| 127 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.67814755 |
| 128 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.67599760 |
| 129 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.67310452 |
| 130 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.66858165 |
| 131 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.66547124 |
| 132 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.65730056 |
| 133 | Phototransduction_Homo sapiens_hsa04744 | 0.65108870 |
| 134 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.64135906 |
| 135 | * N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.63916524 |
| 136 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.63852718 |
| 137 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.63833992 |
| 138 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.61111857 |
| 139 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.60137403 |
| 140 | Asthma_Homo sapiens_hsa05310 | 0.60013489 |
| 141 | Endocytosis_Homo sapiens_hsa04144 | 0.59955607 |
| 142 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.56500804 |
| 143 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.56368904 |
| 144 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.56364770 |
| 145 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.56159471 |
| 146 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.56156566 |
| 147 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.55340122 |
| 148 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.55309493 |
| 149 | Prion diseases_Homo sapiens_hsa05020 | 0.54263876 |
| 150 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.54045690 |
| 151 | RNA transport_Homo sapiens_hsa03013 | 0.53989257 |
| 152 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.53779028 |
| 153 | Thyroid cancer_Homo sapiens_hsa05216 | 0.53665910 |
| 154 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.52699354 |
| 155 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51828455 |
| 156 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51821539 |
| 157 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.51285251 |
| 158 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.51159237 |
| 159 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.51077599 |
| 160 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.50051634 |
| 161 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.49958906 |
| 162 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49714617 |
| 163 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.49303428 |
| 164 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.49242929 |
| 165 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.48925746 |
| 166 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.48922642 |
| 167 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48348525 |
| 168 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48176496 |
| 169 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.48108335 |
| 170 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.47654194 |
| 171 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.47158709 |
| 172 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.46537883 |
| 173 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.46374428 |
| 174 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.46303268 |
| 175 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.45939970 |
| 176 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.45467178 |
| 177 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.45401750 |
| 178 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.44952032 |
| 179 | Spliceosome_Homo sapiens_hsa03040 | 0.44133386 |
| 180 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.42948852 |
| 181 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.42947254 |
| 182 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.42637451 |
| 183 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42071073 |
| 184 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.41848570 |
| 185 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.39956002 |
| 186 | Bile secretion_Homo sapiens_hsa04976 | 0.39467179 |
| 187 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.39111132 |
| 188 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.38617450 |
| 189 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37460646 |
| 190 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36963314 |
| 191 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36473191 |
| 192 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.35855789 |

