ALG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)4.95897415
2meiotic chromosome segregation (GO:0045132)4.81837498
3proteasome assembly (GO:0043248)4.49575235
4ribosome assembly (GO:0042255)4.46631402
5kinetochore organization (GO:0051383)4.38890791
6kinetochore assembly (GO:0051382)4.32088622
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.25797444
8nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.20583969
9RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.20498972
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.20152962
11histone exchange (GO:0043486)4.15886316
12replication fork processing (GO:0031297)4.05290842
13negative regulation of DNA-dependent DNA replication (GO:2000104)4.02928131
14mitotic spindle checkpoint (GO:0071174)3.78394911
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.74581343
16cullin deneddylation (GO:0010388)3.72009814
17DNA integration (GO:0015074)3.67112711
18regulation of DNA endoreduplication (GO:0032875)3.66395241
19oxidative phosphorylation (GO:0006119)3.66194630
20histone mRNA metabolic process (GO:0008334)3.63572002
21DNA replication-dependent nucleosome assembly (GO:0006335)3.63117067
22DNA replication-dependent nucleosome organization (GO:0034723)3.63117067
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63044814
24establishment of integrated proviral latency (GO:0075713)3.61358003
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56924828
26positive regulation of DNA-dependent DNA replication (GO:2000105)3.55484825
27DNA damage response, detection of DNA damage (GO:0042769)3.52017939
28regulation of mitotic spindle checkpoint (GO:1903504)3.47928093
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47928093
30mitotic sister chromatid cohesion (GO:0007064)3.46898127
31DNA synthesis involved in DNA repair (GO:0000731)3.46795080
32protein deneddylation (GO:0000338)3.45301936
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43937766
34isotype switching (GO:0045190)3.43937766
35somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43937766
36purine nucleobase biosynthetic process (GO:0009113)3.41171792
37positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.38142584
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36435811
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36385071
40DNA replication checkpoint (GO:0000076)3.33128984
41ncRNA catabolic process (GO:0034661)3.32284998
42double-strand break repair via nonhomologous end joining (GO:0006303)3.32200512
43non-recombinational repair (GO:0000726)3.32200512
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31326351
45poly(A)+ mRNA export from nucleus (GO:0016973)3.28720884
46mismatch repair (GO:0006298)3.26890765
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26292046
48negative regulation of ligase activity (GO:0051352)3.26292046
49nucleobase biosynthetic process (GO:0046112)3.25540894
50IMP biosynthetic process (GO:0006188)3.23650738
51telomere maintenance via recombination (GO:0000722)3.22431293
52DNA strand elongation (GO:0022616)3.22385846
53positive regulation of ligase activity (GO:0051351)3.22204661
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21084098
55L-serine metabolic process (GO:0006563)3.20139834
56CENP-A containing nucleosome assembly (GO:0034080)3.20039216
57telomere maintenance (GO:0000723)3.18517985
58sister chromatid segregation (GO:0000819)3.17911457
59RNA-dependent DNA replication (GO:0006278)3.17365617
60protein localization to kinetochore (GO:0034501)3.16699803
61mesenchymal cell differentiation involved in kidney development (GO:0072161)3.15562897
62mesenchymal cell differentiation involved in renal system development (GO:2001012)3.15562897
63DNA strand elongation involved in DNA replication (GO:0006271)3.15156827
64telomere maintenance via semi-conservative replication (GO:0032201)3.14347882
65chromatin remodeling at centromere (GO:0031055)3.14112273
66superoxide anion generation (GO:0042554)3.13458599
67telomere maintenance via telomerase (GO:0007004)3.12823359
68replicative senescence (GO:0090399)3.12711580
69telomere organization (GO:0032200)3.12393457
70mitotic sister chromatid segregation (GO:0000070)3.11598320
71regulation of ubiquitin-protein transferase activity (GO:0051438)3.11415098
72metaphase plate congression (GO:0051310)3.11358266
73respiratory chain complex IV assembly (GO:0008535)3.10094764
74signal peptide processing (GO:0006465)3.08196203
75histone H2A acetylation (GO:0043968)3.06867676
76reciprocal DNA recombination (GO:0035825)3.06511484
77reciprocal meiotic recombination (GO:0007131)3.06511484
78peptidyl-histidine modification (GO:0018202)3.01548431
79mitotic recombination (GO:0006312)3.00724106
80regulation of ligase activity (GO:0051340)2.99109363
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98524509
82DNA replication initiation (GO:0006270)2.97783665
83attachment of spindle microtubules to kinetochore (GO:0008608)2.97591509
84DNA catabolic process, exonucleolytic (GO:0000738)2.97126679
85regulation of helicase activity (GO:0051095)2.96215241
86resolution of meiotic recombination intermediates (GO:0000712)2.95073169
87regulation of spindle organization (GO:0090224)2.95055270
88regulation of chromosome segregation (GO:0051983)2.94783574
89negative regulation of DNA recombination (GO:0045910)2.94711101
90rRNA modification (GO:0000154)2.93927534
91regulation of mitotic spindle organization (GO:0060236)2.92915752
92establishment of chromosome localization (GO:0051303)2.89244468
93DNA ligation (GO:0006266)2.88817764
94chaperone-mediated protein transport (GO:0072321)2.88135018
95DNA-dependent DNA replication (GO:0006261)2.88050782
96maturation of 5.8S rRNA (GO:0000460)2.87929597
97telomere maintenance via telomere lengthening (GO:0010833)2.87899012
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86169920
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.86169920
100NADH dehydrogenase complex assembly (GO:0010257)2.86169920
101regulation of non-canonical Wnt signaling pathway (GO:2000050)2.86127714
102adenosine metabolic process (GO:0046085)2.82849745
103DNA double-strand break processing (GO:0000729)2.80813278
104mitotic metaphase plate congression (GO:0007080)2.80381944
105deoxyribonucleotide biosynthetic process (GO:0009263)2.71531438
106regulation of DNA-dependent DNA replication (GO:0090329)2.70740787
107sister chromatid cohesion (GO:0007062)2.70482824
108centriole assembly (GO:0098534)2.70258472
109cellular response to gamma radiation (GO:0071480)2.68441634
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.68282649
111negative regulation of keratinocyte proliferation (GO:0010839)2.68278590
112regulation of telomere maintenance (GO:0032204)2.66181102
113definitive hemopoiesis (GO:0060216)2.64792068
114negative regulation of mast cell activation (GO:0033004)2.64552879
115spindle assembly checkpoint (GO:0071173)2.62141957
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60975446
117hepatocyte differentiation (GO:0070365)2.60342691
118recombinational repair (GO:0000725)2.58028390
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.56232149
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56232149
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55713441
122negative regulation of sister chromatid segregation (GO:0033046)2.55713441
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.55713441
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55713441
125energy homeostasis (GO:0097009)2.55113498
126negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.53525081
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52264487
128positive regulation of DNA-templated transcription, initiation (GO:2000144)2.52244661
129spindle checkpoint (GO:0031577)2.51290093
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.51030569
131positive regulation of cell cycle checkpoint (GO:1901978)2.50588305
132DNA replication-independent nucleosome organization (GO:0034724)2.50383146
133DNA replication-independent nucleosome assembly (GO:0006336)2.50383146
134doxorubicin metabolic process (GO:0044598)2.50298159
135daunorubicin metabolic process (GO:0044597)2.50298159
136polyketide metabolic process (GO:0030638)2.50298159
137intra-S DNA damage checkpoint (GO:0031573)2.49816233
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48580174
139negative regulation of chromosome segregation (GO:0051985)2.48220923
140mitotic spindle assembly checkpoint (GO:0007094)2.47812794
141double-strand break repair via homologous recombination (GO:0000724)2.46799532
142negative regulation of cell cycle G2/M phase transition (GO:1902750)2.46775428
143regulation of mitotic sister chromatid separation (GO:0010965)2.45961879
144regulation of mitotic sister chromatid segregation (GO:0033047)2.45961879
145regulation of sister chromatid segregation (GO:0033045)2.45961879
146negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.44944238
147regulation of centrosome duplication (GO:0010824)2.44872247
148regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.44021215
149microtubule depolymerization (GO:0007019)2.42888067
150IMP metabolic process (GO:0046040)2.42604713
151cellular response to ionizing radiation (GO:0071479)2.42346122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26266820
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25098062
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72843420
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56998210
5CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52393369
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.46134462
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43976982
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43037606
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42222731
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.39585627
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38808438
12GBX2_23144817_ChIP-Seq_PC3_Human2.26267031
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20780086
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19099125
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17000629
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.16658551
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.12458376
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.03037997
19TAF15_26573619_Chip-Seq_HEK293_Human2.00945091
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.00107921
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98884883
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.93029213
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91651068
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91116089
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89536207
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79594767
27EWS_26573619_Chip-Seq_HEK293_Human1.77467321
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74874734
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72568453
30FUS_26573619_Chip-Seq_HEK293_Human1.72024310
31ELK1_19687146_ChIP-ChIP_HELA_Human1.71070895
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.70683239
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67085681
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65380129
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62423671
36IRF1_19129219_ChIP-ChIP_H3396_Human1.61347232
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58945923
38MYC_18940864_ChIP-ChIP_HL60_Human1.58659547
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58316793
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.57791917
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57151523
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.56746834
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55612821
44P53_22387025_ChIP-Seq_ESCs_Mouse1.55529092
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.55062084
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.53849907
47IGF1R_20145208_ChIP-Seq_DFB_Human1.52643266
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.51706020
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51463694
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51054121
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50654244
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48095478
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.46492864
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.46208605
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45307065
56GATA1_22025678_ChIP-Seq_K562_Human1.45080072
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.43569609
58DCP1A_22483619_ChIP-Seq_HELA_Human1.41780934
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.41208271
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40889478
61* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38738135
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38307004
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.38257542
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37157985
65P300_18555785_Chip-Seq_ESCs_Mouse1.37017765
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.35733321
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.33319770
68ZFX_18555785_Chip-Seq_ESCs_Mouse1.31937997
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.31191644
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30401666
71GABP_19822575_ChIP-Seq_HepG2_Human1.28295229
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.28264148
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26406066
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25869031
75TTF2_22483619_ChIP-Seq_HELA_Human1.25074058
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.23859323
77FOXP3_21729870_ChIP-Seq_TREG_Human1.23556693
78PU1_27457419_Chip-Seq_LIVER_Mouse1.23460739
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23309541
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23143070
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22523046
82P300_19829295_ChIP-Seq_ESCs_Human1.19864976
83* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19637100
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18856187
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18695004
86AR_21909140_ChIP-Seq_LNCAP_Human1.18581084
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.18529052
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18405663
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18057677
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.17505431
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17075068
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.17014266
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.16873130
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16582262
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16385469
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16200267
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16056402
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15726175
99VDR_23849224_ChIP-Seq_CD4+_Human1.15283522
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.15203127
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14933127
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14727012
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14665685
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14225113
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12848319
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10042954
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09772466
108VDR_22108803_ChIP-Seq_LS180_Human1.08729681
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06599747
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06505423
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06372555
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.06151659
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.05596840
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03946466
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01900966
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01562438
117KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01440349
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00959537
119ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00465101
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00063110
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99887409
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98871993
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98558380
124NANOG_19829295_ChIP-Seq_ESCs_Human0.98476889
125SOX2_19829295_ChIP-Seq_ESCs_Human0.98476889
126TP53_22573176_ChIP-Seq_HFKS_Human0.97096308
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.96897771
128ER_23166858_ChIP-Seq_MCF-7_Human0.95282850
129STAT3_23295773_ChIP-Seq_U87_Human0.94549523
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93979980
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92955386
132* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92148192
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92128447
134MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92048939
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91447354
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90505230
137MYC_18555785_ChIP-Seq_MESCs_Mouse0.89058911
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88878119
139CBP_20019798_ChIP-Seq_JUKART_Human0.88333622
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88333622
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86597594
142TCF4_22108803_ChIP-Seq_LS180_Human0.84089921
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84080508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.45162499
2MP0008057_abnormal_DNA_replication3.42439207
3MP0001188_hyperpigmentation3.38992960
4MP0006292_abnormal_olfactory_placode3.28522156
5MP0010094_abnormal_chromosome_stability3.27144460
6MP0009697_abnormal_copulation3.05545382
7MP0000566_synostosis2.90489375
8MP0003718_maternal_effect2.88268412
9MP0003693_abnormal_embryo_hatching2.85375208
10MP0002396_abnormal_hematopoietic_system2.74293219
11MP0003111_abnormal_nucleus_morphology2.67008284
12MP0005645_abnormal_hypothalamus_physiol2.66172955
13MP0000569_abnormal_digit_pigmentation2.63407307
14MP0003787_abnormal_imprinting2.56926255
15MP0002876_abnormal_thyroid_physiology2.42419339
16MP0005360_urolithiasis2.41580642
17MP0001986_abnormal_taste_sensitivity2.34750609
18MP0005646_abnormal_pituitary_gland2.07197551
19MP0000015_abnormal_ear_pigmentation2.01367881
20MP0001835_abnormal_antigen_presentation1.94240544
21MP0003121_genomic_imprinting1.90348464
22MP0006035_abnormal_mitochondrial_morpho1.88244889
23MP0005171_absent_coat_pigmentation1.86785543
24MP0008877_abnormal_DNA_methylation1.81715774
25MP0002009_preneoplasia1.80476417
26MP0002736_abnormal_nociception_after1.79750715
27MP0003077_abnormal_cell_cycle1.76252878
28MP0003806_abnormal_nucleotide_metabolis1.74076462
29MP0002277_abnormal_respiratory_mucosa1.73732911
30MP0000516_abnormal_urinary_system1.71322061
31MP0005367_renal/urinary_system_phenotyp1.71322061
32MP0004782_abnormal_surfactant_physiolog1.67747796
33MP0002102_abnormal_ear_morphology1.67348425
34MP0002095_abnormal_skin_pigmentation1.66456503
35MP0008007_abnormal_cellular_replicative1.65141723
36MP0003186_abnormal_redox_activity1.64539583
37MP0001529_abnormal_vocalization1.64295181
38MP0000372_irregular_coat_pigmentation1.60794281
39MP0002938_white_spotting1.60227678
40MP0005408_hypopigmentation1.59594312
41MP0003123_paternal_imprinting1.58510802
42MP0004043_abnormal_pH_regulation1.54631247
43MP0001764_abnormal_homeostasis1.52682491
44MP0006036_abnormal_mitochondrial_physio1.51171429
45MP0002837_dystrophic_cardiac_calcinosis1.51092756
46MP0002132_abnormal_respiratory_system1.49262637
47MP0001346_abnormal_lacrimal_gland1.44273834
48MP0004264_abnormal_extraembryonic_tissu1.40727503
49MP0001186_pigmentation_phenotype1.39938252
50MP0002234_abnormal_pharynx_morphology1.38614282
51MP0000490_abnormal_crypts_of1.36201432
52MP0005075_abnormal_melanosome_morpholog1.32240701
53MP0002751_abnormal_autonomic_nervous1.31772397
54MP0003890_abnormal_embryonic-extraembry1.30651145
55MP0001119_abnormal_female_reproductive1.29728924
56MP0002233_abnormal_nose_morphology1.29468879
57MP0008995_early_reproductive_senescence1.28877923
58MP0000371_diluted_coat_color1.28405952
59MP0000678_abnormal_parathyroid_gland1.26907491
60MP0002877_abnormal_melanocyte_morpholog1.26900407
61MP0001929_abnormal_gametogenesis1.24594110
62MP0003567_abnormal_fetal_cardiomyocyte1.22915877
63MP0002254_reproductive_system_inflammat1.22670957
64MP0002075_abnormal_coat/hair_pigmentati1.21137601
65MP0006072_abnormal_retinal_apoptosis1.21096985
66MP0005395_other_phenotype1.20510445
67MP0003941_abnormal_skin_development1.19889475
68MP0002138_abnormal_hepatobiliary_system1.18982337
69MP0004147_increased_porphyrin_level1.18363913
70MP0000427_abnormal_hair_cycle1.18140230
71MP0001730_embryonic_growth_arrest1.17425375
72MP0003786_premature_aging1.16847714
73MP0005174_abnormal_tail_pigmentation1.12005375
74MP0000383_abnormal_hair_follicle1.10829972
75MP0001177_atelectasis1.10414837
76MP0002090_abnormal_vision1.09214708
77MP0002163_abnormal_gland_morphology1.07366242
78MP0001145_abnormal_male_reproductive1.04788947
79MP0005409_darkened_coat_color1.04416887
80MP0000653_abnormal_sex_gland1.03850446
81MP0005310_abnormal_salivary_gland1.03624225
82MP0000647_abnormal_sebaceous_gland1.03327831
83MP0003880_abnormal_central_pattern1.02929575
84MP0005253_abnormal_eye_physiology1.02436100
85MP0001697_abnormal_embryo_size0.99654323
86MP0003136_yellow_coat_color0.98618416
87MP0001485_abnormal_pinna_reflex0.97382354
88MP0000049_abnormal_middle_ear0.96945768
89MP0002148_abnormal_hypersensitivity_rea0.96505531
90MP0005671_abnormal_response_to0.95369330
91MP0003195_calcinosis0.94768434
92MP0005551_abnormal_eye_electrophysiolog0.94221356
93MP0002085_abnormal_embryonic_tissue0.93405341
94MP0000350_abnormal_cell_proliferation0.92926100
95MP0004957_abnormal_blastocyst_morpholog0.92190159
96MP0002638_abnormal_pupillary_reflex0.90488200
97MP0009785_altered_susceptibility_to0.90292548
98MP0001293_anophthalmia0.90172410
99MP0005389_reproductive_system_phenotype0.89714581
100MP0008789_abnormal_olfactory_epithelium0.87676510
101MP0010307_abnormal_tumor_latency0.86746167
102MP0004808_abnormal_hematopoietic_stem0.86486242
103MP0002160_abnormal_reproductive_system0.85504241
104MP0003183_abnormal_peptide_metabolism0.84706632
105MP0002084_abnormal_developmental_patter0.82429618
106MP0000778_abnormal_nervous_system0.82390801
107MP0002210_abnormal_sex_determination0.81746422
108MP0008932_abnormal_embryonic_tissue0.81299579
109MP0001286_abnormal_eye_development0.80831651
110MP0001968_abnormal_touch/_nociception0.80383066
111MP0000358_abnormal_cell_content/0.79529235
112MP0005379_endocrine/exocrine_gland_phen0.79451784
113MP0005380_embryogenesis_phenotype0.79313760
114MP0001672_abnormal_embryogenesis/_devel0.79313760
115MP0004215_abnormal_myocardial_fiber0.79227201
116MP0005636_abnormal_mineral_homeostasis0.77576969
117MP0001919_abnormal_reproductive_system0.76330531
118MP0003943_abnormal_hepatobiliary_system0.76041096
119MP0003698_abnormal_male_reproductive0.75750850
120MP0000579_abnormal_nail_morphology0.74547096
121MP0005220_abnormal_exocrine_pancreas0.73751053
122MP0008872_abnormal_physiological_respon0.72687468
123MP0000631_abnormal_neuroendocrine_gland0.72169795
124MP0002080_prenatal_lethality0.72019021
125MP0002019_abnormal_tumor_incidence0.71419987
126MP0002419_abnormal_innate_immunity0.70941593
127MP0002928_abnormal_bile_duct0.70467642
128MP0003755_abnormal_palate_morphology0.69967262
129MP0006054_spinal_hemorrhage0.69511607
130MP0003137_abnormal_impulse_conducting0.68628596
131MP0002177_abnormal_outer_ear0.68173376
132MP0008875_abnormal_xenobiotic_pharmacok0.68014295
133MP0003763_abnormal_thymus_physiology0.67696023
134MP0005503_abnormal_tendon_morphology0.67149492
135MP0001324_abnormal_eye_pigmentation0.66737474
136MP0009672_abnormal_birth_weight0.65832556
137MP0000538_abnormal_urinary_bladder0.65670066
138MP0010386_abnormal_urinary_bladder0.65149485
139MP0003221_abnormal_cardiomyocyte_apopto0.65028339
140MP0003937_abnormal_limbs/digits/tail_de0.63406339
141MP0000681_abnormal_thyroid_gland0.63261818
142MP0002693_abnormal_pancreas_physiology0.61960230
143MP0002098_abnormal_vibrissa_morphology0.61618048
144MP0000313_abnormal_cell_death0.61572763
145MP0002398_abnormal_bone_marrow0.61193808
146MP0009703_decreased_birth_body0.61020068
147MP0001790_abnormal_immune_system0.60826087
148MP0005387_immune_system_phenotype0.60826087
149MP0005394_taste/olfaction_phenotype0.58675334
150MP0005499_abnormal_olfactory_system0.58675334
151MP0002109_abnormal_limb_morphology0.57303961
152MP0005647_abnormal_sex_gland0.57010361
153MP0001984_abnormal_olfaction0.55806930
154MP0009764_decreased_sensitivity_to0.55042457

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.27366016
2Chromsome breakage (HP:0040012)6.20163496
3Abnormality of the labia minora (HP:0012880)4.10069867
4Abnormality of the renal collecting system (HP:0004742)3.56183474
5Abnormality of chromosome stability (HP:0003220)3.55448086
6Duplicated collecting system (HP:0000081)3.44960662
7Abnormality of the preputium (HP:0100587)3.29171756
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.28357462
9Meckel diverticulum (HP:0002245)3.11175209
10Abnormality of DNA repair (HP:0003254)3.09935157
11Acute necrotizing encephalopathy (HP:0006965)2.99196225
12Acute encephalopathy (HP:0006846)2.95873787
13Ectopic kidney (HP:0000086)2.94474104
14Abnormality of the ileum (HP:0001549)2.90690912
15Colon cancer (HP:0003003)2.89401397
16Lip pit (HP:0100267)2.88904687
17Increased CSF lactate (HP:0002490)2.71369566
18Osteomalacia (HP:0002749)2.69668942
19Clubbing of toes (HP:0100760)2.64367944
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64069956
21Abnormality of alanine metabolism (HP:0010916)2.64069956
22Hyperalaninemia (HP:0003348)2.64069956
23Abnormal mitochondria in muscle tissue (HP:0008316)2.59189547
24Methylmalonic acidemia (HP:0002912)2.56970905
25Myelodysplasia (HP:0002863)2.56186675
26Progressive macrocephaly (HP:0004481)2.53250085
27Bone marrow hypocellularity (HP:0005528)2.51041671
28Abnormality of serum amino acid levels (HP:0003112)2.50986436
29Birth length less than 3rd percentile (HP:0003561)2.50603839
30Abnormality of methionine metabolism (HP:0010901)2.49274964
31Hyperglycinemia (HP:0002154)2.48196503
32Mitochondrial inheritance (HP:0001427)2.47474644
33Hypoplasia of the fovea (HP:0007750)2.46718639
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.46718639
35Cerebral edema (HP:0002181)2.46216603
36Prostate neoplasm (HP:0100787)2.42322007
37Duodenal stenosis (HP:0100867)2.41438590
38Small intestinal stenosis (HP:0012848)2.41438590
39Alveolar cell carcinoma (HP:0006519)2.38237718
40Pancreatic fibrosis (HP:0100732)2.35946428
41Bifid tongue (HP:0010297)2.35080567
42Progressive inability to walk (HP:0002505)2.32644425
43* Type I transferrin isoform profile (HP:0003642)2.31990681
44Increased serum pyruvate (HP:0003542)2.30349844
45Abnormality of the anterior horn cell (HP:0006802)2.27671070
46Degeneration of anterior horn cells (HP:0002398)2.27671070
47Abnormality of glycolysis (HP:0004366)2.26865997
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25442400
49Methylmalonic aciduria (HP:0012120)2.23308865
50Hepatic necrosis (HP:0002605)2.23071723
51Renal cortical cysts (HP:0000803)2.19053929
52Aplastic anemia (HP:0001915)2.18506045
53Hypothermia (HP:0002045)2.18501864
54Nephroblastoma (Wilms tumor) (HP:0002667)2.18344096
55White forelock (HP:0002211)2.17267654
56Neoplasm of the oral cavity (HP:0100649)2.16979358
57Increased serum lactate (HP:0002151)2.16327084
58Septo-optic dysplasia (HP:0100842)2.16123538
59Abnormality of midbrain morphology (HP:0002418)2.15649009
60Molar tooth sign on MRI (HP:0002419)2.15649009
61Inability to walk (HP:0002540)2.14566599
62Patchy hypopigmentation of hair (HP:0011365)2.13889880
63Abnormality of pyrimidine metabolism (HP:0004353)2.11980845
64Neoplasm of the tracheobronchial system (HP:0100552)2.11829799
65True hermaphroditism (HP:0010459)2.11807776
66Abnormality of serine family amino acid metabolism (HP:0010894)2.11396821
67Abnormality of glycine metabolism (HP:0010895)2.11396821
68Ependymoma (HP:0002888)2.11385772
69Abnormal hair whorl (HP:0010721)2.11220133
70Hepatocellular necrosis (HP:0001404)2.11180816
71Embryonal renal neoplasm (HP:0011794)2.10517706
72Severe visual impairment (HP:0001141)2.07438797
73Small hand (HP:0200055)2.07394516
74Chronic hepatic failure (HP:0100626)2.07355012
75Increased hepatocellular lipid droplets (HP:0006565)2.06838918
76Leukodystrophy (HP:0002415)2.05961492
77Long clavicles (HP:0000890)2.05267632
78Lipid accumulation in hepatocytes (HP:0006561)2.03703231
79Pancreatic islet-cell hyperplasia (HP:0004510)2.03578780
80Gonadotropin excess (HP:0000837)2.02690363
81Rhabdomyosarcoma (HP:0002859)2.02391743
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.01858036
83Neoplasm of the adrenal gland (HP:0100631)2.00314668
84Hyperglycinuria (HP:0003108)1.99468206
85Pancreatic cysts (HP:0001737)1.98004469
86Type 2 muscle fiber atrophy (HP:0003554)1.97881902
87Abnormality of the duodenum (HP:0002246)1.97623808
88Abnormality of the carotid arteries (HP:0005344)1.97578267
89Abnormality of incisor morphology (HP:0011063)1.97467451
90Hypoplasia of the pons (HP:0012110)1.97180113
91Glioma (HP:0009733)1.96308741
92Congenital sensorineural hearing impairment (HP:0008527)1.96161447
93Abnormality of the fingertips (HP:0001211)1.94790245
94Broad-based gait (HP:0002136)1.93938220
95Duplication of thumb phalanx (HP:0009942)1.92380429
96Lactic acidosis (HP:0003128)1.91949493
97Abnormality of the pons (HP:0007361)1.90874549
98Abnormality of the prostate (HP:0008775)1.90806752
99Abolished electroretinogram (ERG) (HP:0000550)1.90344431
100Lethargy (HP:0001254)1.88896928
101Keratoconjunctivitis (HP:0001096)1.87764989
102Mesomelia (HP:0003027)1.86181942
103Protruding tongue (HP:0010808)1.86167699
104Abnormality of macular pigmentation (HP:0008002)1.85334211
105Symptomatic seizures (HP:0011145)1.85091522
106Supernumerary spleens (HP:0009799)1.84526963
107Preaxial hand polydactyly (HP:0001177)1.84173959
108Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83979486
109Volvulus (HP:0002580)1.83862198
110Acute myeloid leukemia (HP:0004808)1.82040118
111Sloping forehead (HP:0000340)1.81407974
112Optic nerve hypoplasia (HP:0000609)1.81232004
113Flat capital femoral epiphysis (HP:0003370)1.80639737
114Agnosia (HP:0010524)1.79593598
115Medial flaring of the eyebrow (HP:0010747)1.79373271
116Median cleft lip (HP:0000161)1.79138174
117Abnormality of the columella (HP:0009929)1.78595268
118Postaxial foot polydactyly (HP:0001830)1.78371114
119Generalized hypopigmentation of hair (HP:0011358)1.78150955
120Abnormality of the incisor (HP:0000676)1.77888583
121Abnormal trabecular bone morphology (HP:0100671)1.77407557
122Hypochromic microcytic anemia (HP:0004840)1.76497555
123Congenital stationary night blindness (HP:0007642)1.76230741
124Hypoglycemic coma (HP:0001325)1.76185227
125Submucous cleft hard palate (HP:0000176)1.76107952
126Premature graying of hair (HP:0002216)1.75873676
127Deep philtrum (HP:0002002)1.75850003
128Hypergonadotropic hypogonadism (HP:0000815)1.75831641
129Rough bone trabeculation (HP:0100670)1.75812663
130Oligohydramnios (HP:0001562)1.75653657
131Neonatal hypoglycemia (HP:0001998)1.73703480
132* Abnormal protein glycosylation (HP:0012346)1.73687974
133* Abnormal glycosylation (HP:0012345)1.73687974
134* Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73687974
135* Abnormal protein N-linked glycosylation (HP:0012347)1.73687974
136Tubulointerstitial nephritis (HP:0001970)1.73579558
137Triphalangeal thumb (HP:0001199)1.73558410
138Abnormality of the renal cortex (HP:0011035)1.73321921
139Fair hair (HP:0002286)1.72623910
140Abnormality of the clitoris (HP:0000056)1.71104278
141Abnormality of endocrine pancreas physiology (HP:0012093)1.71022475
142Abnormality of the pancreatic islet cells (HP:0006476)1.71022475
143Amniotic constriction ring (HP:0009775)1.69798089
144Abnormality of placental membranes (HP:0011409)1.69798089
145Gastrointestinal atresia (HP:0002589)1.69706551
146Carpal bone hypoplasia (HP:0001498)1.69261607
147Genital tract atresia (HP:0001827)1.68530433
148Cerebral hypomyelination (HP:0006808)1.68488159
149Stenosis of the external auditory canal (HP:0000402)1.68327845
150Abnormal lung lobation (HP:0002101)1.68252080
151Patellar aplasia (HP:0006443)1.67954271
152Postnatal microcephaly (HP:0005484)1.67939261
153Retrobulbar optic neuritis (HP:0100654)1.67493490
154Optic neuritis (HP:0100653)1.67493490
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.67493189
156Intestinal atresia (HP:0011100)1.67000348
157Cleft eyelid (HP:0000625)1.66966309
158Absent eyebrow (HP:0002223)1.64969328
159Abnormality of the fovea (HP:0000493)1.64008867
160Absent radius (HP:0003974)1.62639799
161Keratitis (HP:0000491)1.62112244
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.61508650
163Homocystinuria (HP:0002156)1.60981935
164Abnormality of homocysteine metabolism (HP:0010919)1.60981935
165Enlarged kidneys (HP:0000105)1.60640790
166Aplasia/Hypoplasia of the macula (HP:0008059)1.59831621
167Astigmatism (HP:0000483)1.59592349
168Optic nerve coloboma (HP:0000588)1.59469267
169Poor coordination (HP:0002370)1.56481907
170Medulloblastoma (HP:0002885)1.55638203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.54775111
2ZAK3.35870977
3PRPF4B2.76264377
4SRPK12.74754569
5IRAK42.66131425
6MAP3K142.56953983
7WNK32.50288708
8AKT32.48683682
9CDC72.43789249
10ERBB32.29579013
11EIF2AK22.27129242
12IRAK32.23025275
13STK162.16414299
14INSRR2.15473161
15NEK12.12576697
16VRK22.10133014
17MAP4K22.04604653
18CDK81.99954650
19CCNB11.98275000
20MST41.97259878
21ACVR1B1.90445828
22PLK41.85409845
23SIK31.82777652
24CASK1.81407339
25BRSK21.75367440
26NUAK11.73489742
27MKNK11.71541264
28EIF2AK31.66607882
29YES11.65984422
30TXK1.64490441
31ATR1.62139924
32TNIK1.58582898
33PDK21.58086906
34PASK1.57625229
35VRK11.56229347
36EIF2AK11.50444315
37MKNK21.49969152
38CDK31.44905813
39FRK1.37989785
40SGK21.36787015
41TAOK31.33038856
42BMPR21.27972830
43EPHA31.26962335
44TAOK21.26191602
45BMPR1B1.25932516
46BCKDK1.24150395
47TNK21.21568628
48PLK31.18231073
49WEE11.16532638
50STK38L1.11899458
51PBK1.09583233
52PLK11.08795406
53BRD41.08623084
54TEC1.06141952
55CHEK21.04336909
56CDK71.01847132
57JAK31.01719964
58BRSK10.95016255
59TSSK60.90255426
60TGFBR10.89963396
61TTK0.89721683
62CHUK0.89374904
63TAF10.87240405
64RPS6KB10.87095768
65STK240.86242525
66NEK60.85464215
67OXSR10.85300567
68NME10.84847471
69NEK90.84687805
70ATM0.78948242
71AURKB0.77072323
72MAP3K120.76507778
73IKBKB0.75276623
74MAP3K40.74372614
75SGK30.74336932
76CDK120.73417401
77TRPM70.72135392
78CSNK1G10.70883075
79FLT30.69955983
80STK40.69416043
81MUSK0.69292763
82STK30.67790354
83CSNK1G20.65273356
84PNCK0.63476495
85CLK10.62392111
86BUB10.62260253
87LATS10.62197732
88EPHA20.59654065
89ADRBK20.59477703
90CHEK10.59276275
91BCR0.58956414
92PIK3CA0.58548581
93CSNK1G30.57645578
94PLK20.57158916
95IRAK20.56109701
96BTK0.54262654
97ERBB40.53788168
98GRK10.53685852
99PRKDC0.50135487
100TGFBR20.49655527
101PIM10.49315237
102PINK10.48023200
103PKN20.47366380
104IKBKE0.45535145
105CDK190.45259089
106CDK90.45038794
107PRKCE0.44667383
108DMPK0.44052015
109LYN0.42777551
110CSNK1A1L0.42687755
111SGK4940.42660822
112SGK2230.42660822
113FGFR10.42099832
114MARK30.41860965
115CSNK2A10.41764170
116DYRK20.41329932
117MINK10.40080257
118CDK10.39981802
119LIMK10.39883791
120AKT10.39101744
121DYRK30.39080939
122OBSCN0.37924095
123RPS6KA50.37803998
124MAPK130.37341615
125NLK0.36901112
126PRKCG0.36292801
127MAP2K70.35449087
128CDK20.35339980
129IRAK10.34877763
130TLK10.34749486
131PAK30.34380796
132NEK20.34354968
133STK390.34336755
134PIK3CG0.34200524
135RPS6KA40.33144640
136CAMK1D0.33022839
137MAPK140.32927396
138DAPK10.32896166
139CSF1R0.32889160
140FER0.31777823
141CSNK2A20.31683127
142MAPK70.31243486
143FGR0.29699517
144CAMK2A0.26887437

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.61638068
2Mismatch repair_Homo sapiens_hsa034303.49111109
3Homologous recombination_Homo sapiens_hsa034403.31631442
4Fanconi anemia pathway_Homo sapiens_hsa034603.27587354
5Non-homologous end-joining_Homo sapiens_hsa034503.04976536
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.98807793
7Base excision repair_Homo sapiens_hsa034102.70446113
8Protein export_Homo sapiens_hsa030602.50249570
9Cell cycle_Homo sapiens_hsa041102.39951857
10Nucleotide excision repair_Homo sapiens_hsa034202.39411128
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31515776
12One carbon pool by folate_Homo sapiens_hsa006702.26522545
13Propanoate metabolism_Homo sapiens_hsa006402.23473283
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18144203
15Oxidative phosphorylation_Homo sapiens_hsa001902.07871416
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.06750899
17Parkinsons disease_Homo sapiens_hsa050121.93162786
18RNA polymerase_Homo sapiens_hsa030201.88666980
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83178018
20RNA degradation_Homo sapiens_hsa030181.82709649
21Basal transcription factors_Homo sapiens_hsa030221.80770081
22Pyrimidine metabolism_Homo sapiens_hsa002401.73431270
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71863909
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62099216
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57475642
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56620748
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51589930
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.49807299
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.48387742
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43426067
31Huntingtons disease_Homo sapiens_hsa050161.38009913
32Spliceosome_Homo sapiens_hsa030401.34484996
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31093057
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31000982
35Herpes simplex infection_Homo sapiens_hsa051681.30924713
36Purine metabolism_Homo sapiens_hsa002301.29788433
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.28468900
38Vitamin digestion and absorption_Homo sapiens_hsa049771.28463965
39Pyruvate metabolism_Homo sapiens_hsa006201.28032257
40RNA transport_Homo sapiens_hsa030131.27136641
41Autoimmune thyroid disease_Homo sapiens_hsa053201.26626588
42Fatty acid elongation_Homo sapiens_hsa000621.21246987
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18310217
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17628175
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17028605
46Measles_Homo sapiens_hsa051621.16121208
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13876785
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13569515
49Alzheimers disease_Homo sapiens_hsa050101.10440693
50p53 signaling pathway_Homo sapiens_hsa041151.08453118
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07524575
52Allograft rejection_Homo sapiens_hsa053301.05523588
53Ribosome_Homo sapiens_hsa030101.04956970
54Selenocompound metabolism_Homo sapiens_hsa004501.04444738
55Oocyte meiosis_Homo sapiens_hsa041141.04360999
56Circadian rhythm_Homo sapiens_hsa047101.02938932
57Butanoate metabolism_Homo sapiens_hsa006501.02546490
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02358825
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01325074
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98203928
61Arachidonic acid metabolism_Homo sapiens_hsa005900.98005795
62mRNA surveillance pathway_Homo sapiens_hsa030150.96708931
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95627486
64Systemic lupus erythematosus_Homo sapiens_hsa053220.95571298
65Peroxisome_Homo sapiens_hsa041460.94540184
66Regulation of autophagy_Homo sapiens_hsa041400.91313808
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90519442
68ABC transporters_Homo sapiens_hsa020100.89737387
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89163478
70Caffeine metabolism_Homo sapiens_hsa002320.85116788
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83686393
72Hematopoietic cell lineage_Homo sapiens_hsa046400.82837224
73Sphingolipid metabolism_Homo sapiens_hsa006000.82677153
74* N-Glycan biosynthesis_Homo sapiens_hsa005100.82126729
75Biosynthesis of amino acids_Homo sapiens_hsa012300.81796914
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80304939
77Carbon metabolism_Homo sapiens_hsa012000.78684604
78Proteasome_Homo sapiens_hsa030500.78170966
79Influenza A_Homo sapiens_hsa051640.77773773
80Leishmaniasis_Homo sapiens_hsa051400.77405246
81Legionellosis_Homo sapiens_hsa051340.77253217
82Primary immunodeficiency_Homo sapiens_hsa053400.77047899
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.76620142
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76570192
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76274237
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.74168264
87Asthma_Homo sapiens_hsa053100.73754233
88Glutathione metabolism_Homo sapiens_hsa004800.70831188
89Graft-versus-host disease_Homo sapiens_hsa053320.68184730
90Tryptophan metabolism_Homo sapiens_hsa003800.67310667
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66211652
92Fatty acid metabolism_Homo sapiens_hsa012120.65924876
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.63709018
94Folate biosynthesis_Homo sapiens_hsa007900.63207138
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59470897
96Antigen processing and presentation_Homo sapiens_hsa046120.58779020
97Epstein-Barr virus infection_Homo sapiens_hsa051690.58089942
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.57977383
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57939640
100Sulfur metabolism_Homo sapiens_hsa009200.57234246
101Fatty acid degradation_Homo sapiens_hsa000710.55275579
102Viral carcinogenesis_Homo sapiens_hsa052030.54193619
103Type I diabetes mellitus_Homo sapiens_hsa049400.52879379
104beta-Alanine metabolism_Homo sapiens_hsa004100.51003262
105Melanoma_Homo sapiens_hsa052180.50058216
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.48348182
107Steroid biosynthesis_Homo sapiens_hsa001000.47820805
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47253396
109HTLV-I infection_Homo sapiens_hsa051660.45216761
110Other glycan degradation_Homo sapiens_hsa005110.44428059
111Hepatitis B_Homo sapiens_hsa051610.44013714
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43165265
113Phototransduction_Homo sapiens_hsa047440.42690430
114Starch and sucrose metabolism_Homo sapiens_hsa005000.41777635
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41562907
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41045628
117Inositol phosphate metabolism_Homo sapiens_hsa005620.40521762
118Pentose phosphate pathway_Homo sapiens_hsa000300.40291753
119Chemical carcinogenesis_Homo sapiens_hsa052040.39584042
120Galactose metabolism_Homo sapiens_hsa000520.39202419
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38774194
122Lysine degradation_Homo sapiens_hsa003100.38545069
123Vitamin B6 metabolism_Homo sapiens_hsa007500.37636775
124Retinol metabolism_Homo sapiens_hsa008300.36009041
125TNF signaling pathway_Homo sapiens_hsa046680.35450354
126Nicotine addiction_Homo sapiens_hsa050330.34951133
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34210627
128Phagosome_Homo sapiens_hsa041450.34126763
129Histidine metabolism_Homo sapiens_hsa003400.33917419
130Linoleic acid metabolism_Homo sapiens_hsa005910.33893962
131Taste transduction_Homo sapiens_hsa047420.33640932
132Olfactory transduction_Homo sapiens_hsa047400.33377623
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30441303
134MicroRNAs in cancer_Homo sapiens_hsa052060.29369333
135Prostate cancer_Homo sapiens_hsa052150.29358618
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28936773
137* Metabolic pathways_Homo sapiens_hsa011000.28669377
138Fat digestion and absorption_Homo sapiens_hsa049750.28126889
139Apoptosis_Homo sapiens_hsa042100.27831376
140Nitrogen metabolism_Homo sapiens_hsa009100.27653976
141Ether lipid metabolism_Homo sapiens_hsa005650.25679487
142Small cell lung cancer_Homo sapiens_hsa052220.24837278
143TGF-beta signaling pathway_Homo sapiens_hsa043500.24164912
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22106891
145Cardiac muscle contraction_Homo sapiens_hsa042600.20619342
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13085930

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