Rank | Gene Set | Z-score |
---|---|---|
1 | proteasome assembly (GO:0043248) | 5.19010391 |
2 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.06059486 |
3 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.91633135 |
4 | DNA strand elongation (GO:0022616) | 4.87548320 |
5 | protein localization to kinetochore (GO:0034501) | 4.61105693 |
6 | melanin biosynthetic process (GO:0042438) | 4.59173399 |
7 | DNA unwinding involved in DNA replication (GO:0006268) | 4.51296982 |
8 | telomere maintenance via recombination (GO:0000722) | 4.40323808 |
9 | mitotic metaphase plate congression (GO:0007080) | 4.35631103 |
10 | DNA replication initiation (GO:0006270) | 4.33400456 |
11 | ribosomal small subunit assembly (GO:0000028) | 4.28966872 |
12 | secondary metabolite biosynthetic process (GO:0044550) | 4.24637289 |
13 | mitotic recombination (GO:0006312) | 4.16647352 |
14 | protein localization to chromosome, centromeric region (GO:0071459) | 4.11606234 |
15 | CENP-A containing nucleosome assembly (GO:0034080) | 4.09812787 |
16 | DNA deamination (GO:0045006) | 4.09572767 |
17 | melanin metabolic process (GO:0006582) | 4.03466909 |
18 | metaphase plate congression (GO:0051310) | 3.98001273 |
19 | DNA replication checkpoint (GO:0000076) | 3.92078064 |
20 | chromatin remodeling at centromere (GO:0031055) | 3.91293350 |
21 | telomere maintenance via telomere lengthening (GO:0010833) | 3.91114006 |
22 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.91034034 |
23 | kinetochore organization (GO:0051383) | 3.79965296 |
24 | nucleobase biosynthetic process (GO:0046112) | 3.78034245 |
25 | mitotic nuclear envelope disassembly (GO:0007077) | 3.75652084 |
26 | negative regulation of ligase activity (GO:0051352) | 3.75295185 |
27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.75295185 |
28 | DNA double-strand break processing (GO:0000729) | 3.71987898 |
29 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.67477418 |
30 | IMP biosynthetic process (GO:0006188) | 3.62368737 |
31 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.59451509 |
32 | DNA ligation (GO:0006266) | 3.58175566 |
33 | establishment of chromosome localization (GO:0051303) | 3.57660906 |
34 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.57540338 |
35 | DNA replication-independent nucleosome organization (GO:0034724) | 3.57540338 |
36 | meiotic chromosome segregation (GO:0045132) | 3.56466244 |
37 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.54968300 |
38 | cullin deneddylation (GO:0010388) | 3.54231014 |
39 | spindle checkpoint (GO:0031577) | 3.51836061 |
40 | establishment of integrated proviral latency (GO:0075713) | 3.51069064 |
41 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.49180244 |
42 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47317737 |
43 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47317737 |
44 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47317737 |
45 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.45855969 |
46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.45855969 |
47 | regulation of spindle organization (GO:0090224) | 3.43539465 |
48 | nuclear envelope disassembly (GO:0051081) | 3.40512690 |
49 | membrane disassembly (GO:0030397) | 3.40512690 |
50 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.40159068 |
51 | maturation of SSU-rRNA (GO:0030490) | 3.39185515 |
52 | mitotic sister chromatid segregation (GO:0000070) | 3.38763706 |
53 | regulation of DNA endoreduplication (GO:0032875) | 3.38176667 |
54 | purine nucleobase biosynthetic process (GO:0009113) | 3.37452828 |
55 | formation of translation preinitiation complex (GO:0001731) | 3.36556308 |
56 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.36487449 |
57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.36487449 |
58 | mitotic chromosome condensation (GO:0007076) | 3.36433075 |
59 | mitotic spindle checkpoint (GO:0071174) | 3.36393167 |
60 | viral transcription (GO:0019083) | 3.36189987 |
61 | translational termination (GO:0006415) | 3.35346387 |
62 | regulation of mitochondrial translation (GO:0070129) | 3.34905326 |
63 | protein deneddylation (GO:0000338) | 3.34616152 |
64 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.34596095 |
65 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.34596095 |
66 | IMP metabolic process (GO:0046040) | 3.34299510 |
67 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.32859258 |
68 | kinetochore assembly (GO:0051382) | 3.31703145 |
69 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.30690394 |
70 | replication fork processing (GO:0031297) | 3.30374431 |
71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.29444441 |
72 | histone-serine phosphorylation (GO:0035404) | 3.26810993 |
73 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.24832272 |
74 | non-recombinational repair (GO:0000726) | 3.24832272 |
75 | maturation of 5.8S rRNA (GO:0000460) | 3.24272615 |
76 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.24047788 |
77 | negative regulation of sister chromatid segregation (GO:0033046) | 3.24047788 |
78 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.24047788 |
79 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.24047788 |
80 | negative regulation of chromosome segregation (GO:0051985) | 3.22699957 |
81 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.22590148 |
82 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.20867367 |
83 | histone exchange (GO:0043486) | 3.17552091 |
84 | sister chromatid segregation (GO:0000819) | 3.16635557 |
85 | resolution of meiotic recombination intermediates (GO:0000712) | 3.15801330 |
86 | ribosomal large subunit biogenesis (GO:0042273) | 3.15429392 |
87 | translesion synthesis (GO:0019985) | 3.14832770 |
88 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.14273675 |
89 | positive regulation of ligase activity (GO:0051351) | 3.13985212 |
90 | mitotic spindle assembly checkpoint (GO:0007094) | 3.12648952 |
91 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.12415914 |
92 | spindle assembly checkpoint (GO:0071173) | 3.11160735 |
93 | telomere organization (GO:0032200) | 3.10662375 |
94 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.10430867 |
95 | telomere maintenance (GO:0000723) | 3.10351822 |
96 | translational elongation (GO:0006414) | 3.09080590 |
97 | pseudouridine synthesis (GO:0001522) | 3.08002123 |
98 | synapsis (GO:0007129) | 3.07324096 |
99 | cotranslational protein targeting to membrane (GO:0006613) | 3.04978494 |
100 | chaperone-mediated protein transport (GO:0072321) | 3.04767838 |
101 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.03297104 |
102 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.02816413 |
103 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.02774658 |
104 | protein targeting to ER (GO:0045047) | 3.02102551 |
105 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.01604890 |
106 | protein complex biogenesis (GO:0070271) | 3.00727877 |
107 | negative regulation of RNA splicing (GO:0033119) | 3.00689254 |
108 | regulation of chromosome segregation (GO:0051983) | 3.00598515 |
109 | histone mRNA metabolic process (GO:0008334) | 3.00512292 |
110 | translational initiation (GO:0006413) | 2.98728985 |
111 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.98659414 |
112 | regulation of ligase activity (GO:0051340) | 2.98171783 |
113 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.97148484 |
114 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.97148484 |
115 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.95028037 |
116 | respiratory chain complex IV assembly (GO:0008535) | 2.94975003 |
117 | L-serine metabolic process (GO:0006563) | 2.90724601 |
118 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.90362540 |
119 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.87578298 |
120 | base-excision repair (GO:0006284) | 2.86706542 |
121 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.86542442 |
122 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.86172254 |
123 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.85164105 |
124 | protein localization to endoplasmic reticulum (GO:0070972) | 2.84538918 |
125 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.84354961 |
126 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.84354961 |
127 | ribosome biogenesis (GO:0042254) | 2.82976985 |
128 | postreplication repair (GO:0006301) | 2.82603102 |
129 | DNA duplex unwinding (GO:0032508) | 2.82074743 |
130 | DNA geometric change (GO:0032392) | 2.80917346 |
131 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.80682016 |
132 | spliceosomal snRNP assembly (GO:0000387) | 2.79100296 |
133 | mitotic sister chromatid cohesion (GO:0007064) | 2.77358008 |
134 | protein localization to chromosome (GO:0034502) | 2.76167640 |
135 | cell cycle G1/S phase transition (GO:0044843) | 2.76073312 |
136 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.76073312 |
137 | regulation of mitotic spindle organization (GO:0060236) | 2.74554680 |
138 | chromosome segregation (GO:0007059) | 2.74447313 |
139 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.72180973 |
140 | ribosomal small subunit biogenesis (GO:0042274) | 2.71997219 |
141 | DNA topological change (GO:0006265) | 2.69497609 |
142 | mismatch repair (GO:0006298) | 2.69037345 |
143 | rRNA processing (GO:0006364) | 2.68757260 |
144 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.66320074 |
145 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.66015080 |
146 | DNA-dependent DNA replication (GO:0006261) | 2.65714224 |
147 | nuclear pore organization (GO:0006999) | 2.65403871 |
148 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.63578024 |
149 | ribosome assembly (GO:0042255) | 2.63107956 |
150 | nuclear envelope organization (GO:0006998) | 2.62801376 |
151 | DNA conformation change (GO:0071103) | 2.61936422 |
152 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.61858881 |
153 | cellular protein complex disassembly (GO:0043624) | 2.61773214 |
154 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.60992513 |
155 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.59713939 |
156 | chromatin assembly or disassembly (GO:0006333) | 2.59058268 |
157 | negative regulation of mRNA processing (GO:0050686) | 2.58465635 |
158 | rRNA metabolic process (GO:0016072) | 2.57619198 |
159 | translation (GO:0006412) | 2.57377758 |
160 | viral life cycle (GO:0019058) | 2.57344976 |
161 | mitotic cell cycle (GO:0000278) | 2.57339395 |
162 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.56414895 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.87054266 |
2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.24939097 |
3 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.83215493 |
4 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.78017723 |
5 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.66165924 |
6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.21688490 |
7 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.13353389 |
8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.05508134 |
9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.82544882 |
10 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.69140545 |
11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.63769446 |
12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.61908168 |
13 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.53242063 |
14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.47610531 |
15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.47283504 |
16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38544230 |
17 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.37856374 |
18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.30184416 |
19 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.30024274 |
20 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.25243802 |
21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.24137258 |
22 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.15532234 |
23 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.15381318 |
24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.13775878 |
25 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.10045439 |
26 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.08992391 |
27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.04471053 |
28 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.00585084 |
29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.99391591 |
30 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.96991382 |
31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.96042802 |
32 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.87566182 |
33 | MYC_22102868_ChIP-Seq_BL_Human | 1.78832901 |
34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78136176 |
35 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.77008266 |
36 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.76194498 |
37 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72374542 |
38 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.71667577 |
39 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69033867 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68524407 |
41 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66974023 |
42 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.63904491 |
43 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.63674181 |
44 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.62900807 |
45 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.62495661 |
46 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.61945041 |
47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.61797682 |
48 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.60905100 |
49 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.58519026 |
50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.58325277 |
51 | EWS_26573619_Chip-Seq_HEK293_Human | 1.51641403 |
52 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.51111322 |
53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.51027198 |
54 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.49250893 |
55 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.47032376 |
56 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.44679731 |
57 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.43625605 |
58 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.40240378 |
59 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.40097123 |
60 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.39596632 |
61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.39415550 |
62 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34535557 |
63 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.32297484 |
64 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.30838675 |
65 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30264676 |
66 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.29534409 |
67 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.29309233 |
68 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28815796 |
69 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.28114854 |
70 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.26422115 |
71 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.25172670 |
72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24472118 |
73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.21854453 |
74 | FUS_26573619_Chip-Seq_HEK293_Human | 1.21731665 |
75 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.20331033 |
76 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.20068988 |
77 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.19282679 |
78 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.18893836 |
79 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14733407 |
80 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.13267736 |
81 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.12482454 |
82 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11176404 |
83 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.10238593 |
84 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09832922 |
85 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.08677741 |
86 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.08410664 |
87 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.06757784 |
88 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06222216 |
89 | MYB_26560356_Chip-Seq_TH2_Human | 1.05012531 |
90 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.03258090 |
91 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.01397547 |
92 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99716386 |
93 | MYB_26560356_Chip-Seq_TH1_Human | 0.98914283 |
94 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.98785237 |
95 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.97546750 |
96 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.97334209 |
97 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.94712099 |
98 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.93751520 |
99 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.93003527 |
100 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.92761184 |
101 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.92731767 |
102 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.92222505 |
103 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.91687704 |
104 | GATA1_22025678_ChIP-Seq_K562_Human | 0.90061922 |
105 | UTX_26944678_Chip-Seq_JUKART_Human | 0.89797447 |
106 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.89219558 |
107 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.87754380 |
108 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.86869614 |
109 | MAF_26560356_Chip-Seq_TH1_Human | 0.86752632 |
110 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.84576292 |
111 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.84498905 |
112 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84272431 |
113 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.83802990 |
114 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.83415824 |
115 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.83264873 |
116 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.82258241 |
117 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81924463 |
118 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.81821009 |
119 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.81771746 |
120 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.80725129 |
121 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80591454 |
122 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.79656649 |
123 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.79082464 |
124 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.78636283 |
125 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.76395582 |
126 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.71265913 |
127 | P300_19829295_ChIP-Seq_ESCs_Human | 0.71136978 |
128 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.70843604 |
129 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.66206023 |
130 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.63982392 |
131 | * POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.61249617 |
132 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.61024843 |
133 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.59559032 |
134 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.58968393 |
135 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.58146276 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0000372_irregular_coat_pigmentation | 5.89474181 |
2 | MP0003693_abnormal_embryo_hatching | 4.78984881 |
3 | MP0010094_abnormal_chromosome_stability | 4.26519786 |
4 | MP0005408_hypopigmentation | 4.15495317 |
5 | MP0003111_abnormal_nucleus_morphology | 3.73902884 |
6 | MP0002396_abnormal_hematopoietic_system | 3.55979324 |
7 | MP0004957_abnormal_blastocyst_morpholog | 3.55571255 |
8 | MP0003136_yellow_coat_color | 3.48421399 |
9 | MP0005171_absent_coat_pigmentation | 3.43403226 |
10 | MP0003077_abnormal_cell_cycle | 3.38184623 |
11 | MP0008057_abnormal_DNA_replication | 3.11446449 |
12 | MP0008058_abnormal_DNA_repair | 2.68129592 |
13 | MP0002938_white_spotting | 2.67436315 |
14 | MP0008007_abnormal_cellular_replicative | 2.49833770 |
15 | MP0006054_spinal_hemorrhage | 2.46451928 |
16 | MP0002102_abnormal_ear_morphology | 2.26587945 |
17 | MP0001835_abnormal_antigen_presentation | 2.17886795 |
18 | MP0004808_abnormal_hematopoietic_stem | 2.17783476 |
19 | MP0000490_abnormal_crypts_of | 2.17737362 |
20 | MP0008932_abnormal_embryonic_tissue | 2.00013858 |
21 | MP0009333_abnormal_splenocyte_physiolog | 1.93811057 |
22 | MP0003763_abnormal_thymus_physiology | 1.92106393 |
23 | MP0001545_abnormal_hematopoietic_system | 1.77282640 |
24 | MP0005397_hematopoietic_system_phenotyp | 1.77282640 |
25 | MP0002398_abnormal_bone_marrow | 1.76647300 |
26 | MP0000371_diluted_coat_color | 1.69656500 |
27 | MP0000350_abnormal_cell_proliferation | 1.68601342 |
28 | MP0005671_abnormal_response_to | 1.67376314 |
29 | MP0001324_abnormal_eye_pigmentation | 1.66955392 |
30 | MP0001730_embryonic_growth_arrest | 1.61777242 |
31 | MP0008877_abnormal_DNA_methylation | 1.58388876 |
32 | MP0000689_abnormal_spleen_morphology | 1.57153227 |
33 | MP0002722_abnormal_immune_system | 1.56681363 |
34 | MP0002090_abnormal_vision | 1.55651066 |
35 | MP0010352_gastrointestinal_tract_polyps | 1.53787593 |
36 | MP0006292_abnormal_olfactory_placode | 1.53673988 |
37 | MP0002019_abnormal_tumor_incidence | 1.53306523 |
38 | MP0003436_decreased_susceptibility_to | 1.51746142 |
39 | MP0001800_abnormal_humoral_immune | 1.48543424 |
40 | MP0001853_heart_inflammation | 1.47502456 |
41 | MP0000703_abnormal_thymus_morphology | 1.44947270 |
42 | MP0010307_abnormal_tumor_latency | 1.44807591 |
43 | MP0002429_abnormal_blood_cell | 1.43588121 |
44 | MP0009785_altered_susceptibility_to | 1.43236916 |
45 | MP0003890_abnormal_embryonic-extraembry | 1.42994166 |
46 | MP0004147_increased_porphyrin_level | 1.42938744 |
47 | MP0002452_abnormal_antigen_presenting | 1.42363988 |
48 | MP0001293_anophthalmia | 1.42210150 |
49 | MP0005025_abnormal_response_to | 1.40893076 |
50 | MP0000716_abnormal_immune_system | 1.40157480 |
51 | MP0000858_altered_metastatic_potential | 1.39538010 |
52 | MP0002420_abnormal_adaptive_immunity | 1.39152102 |
53 | MP0000313_abnormal_cell_death | 1.38516061 |
54 | MP0001819_abnormal_immune_cell | 1.36882352 |
55 | MP0000685_abnormal_immune_system | 1.36731302 |
56 | MP0002877_abnormal_melanocyte_morpholog | 1.36215717 |
57 | MP0006036_abnormal_mitochondrial_physio | 1.35457712 |
58 | MP0005464_abnormal_platelet_physiology | 1.35042530 |
59 | MP0003656_abnormal_erythrocyte_physiolo | 1.33986849 |
60 | MP0002419_abnormal_innate_immunity | 1.33377327 |
61 | MP0000465_gastrointestinal_hemorrhage | 1.32430589 |
62 | MP0005075_abnormal_melanosome_morpholog | 1.30432636 |
63 | MP0002723_abnormal_immune_serum | 1.28340013 |
64 | MP0006072_abnormal_retinal_apoptosis | 1.27761442 |
65 | MP0005000_abnormal_immune_tolerance | 1.27532630 |
66 | MP0003786_premature_aging | 1.26656697 |
67 | MP0001529_abnormal_vocalization | 1.22771646 |
68 | MP0005253_abnormal_eye_physiology | 1.22485779 |
69 | MP0002075_abnormal_coat/hair_pigmentati | 1.21228899 |
70 | MP0002080_prenatal_lethality | 1.20184736 |
71 | MP0003186_abnormal_redox_activity | 1.20119653 |
72 | MP0003123_paternal_imprinting | 1.19709620 |
73 | MP0004381_abnormal_hair_follicle | 1.17690995 |
74 | MP0001697_abnormal_embryo_size | 1.17314419 |
75 | MP0003806_abnormal_nucleotide_metabolis | 1.16741964 |
76 | MP0002166_altered_tumor_susceptibility | 1.16465508 |
77 | MP0002405_respiratory_system_inflammati | 1.16130232 |
78 | MP0003195_calcinosis | 1.14778731 |
79 | MP0005248_abnormal_Harderian_gland | 1.13862748 |
80 | MP0010030_abnormal_orbit_morphology | 1.13576148 |
81 | MP0005174_abnormal_tail_pigmentation | 1.13470976 |
82 | MP0001186_pigmentation_phenotype | 1.13068836 |
83 | MP0010155_abnormal_intestine_physiology | 1.11889526 |
84 | MP0001672_abnormal_embryogenesis/_devel | 1.11572717 |
85 | MP0005380_embryogenesis_phenotype | 1.11572717 |
86 | MP0002148_abnormal_hypersensitivity_rea | 1.11309553 |
87 | MP0003984_embryonic_growth_retardation | 1.09337534 |
88 | MP0003941_abnormal_skin_development | 1.05243415 |
89 | MP0006035_abnormal_mitochondrial_morpho | 1.05100072 |
90 | MP0002088_abnormal_embryonic_growth/wei | 1.04975022 |
91 | MP0002095_abnormal_skin_pigmentation | 1.04097022 |
92 | MP0000647_abnormal_sebaceous_gland | 1.02561627 |
93 | MP0001929_abnormal_gametogenesis | 0.98580709 |
94 | MP0002006_tumorigenesis | 0.97048800 |
95 | MP0005076_abnormal_cell_differentiation | 0.97007925 |
96 | MP0008789_abnormal_olfactory_epithelium | 0.96745975 |
97 | MP0003567_abnormal_fetal_cardiomyocyte | 0.96670946 |
98 | MP0002163_abnormal_gland_morphology | 0.95536969 |
99 | MP0001845_abnormal_inflammatory_respons | 0.93889392 |
100 | MP0002086_abnormal_extraembryonic_tissu | 0.93464787 |
101 | MP0001873_stomach_inflammation | 0.92798090 |
102 | MP0001915_intracranial_hemorrhage | 0.92208727 |
103 | MP0003724_increased_susceptibility_to | 0.91928491 |
104 | MP0002233_abnormal_nose_morphology | 0.91820362 |
105 | MP0003172_abnormal_lysosome_physiology | 0.91215730 |
106 | MP0001790_abnormal_immune_system | 0.90056941 |
107 | MP0005387_immune_system_phenotype | 0.90056941 |
108 | MP0005395_other_phenotype | 0.87486975 |
109 | MP0002160_abnormal_reproductive_system | 0.86747668 |
110 | MP0003937_abnormal_limbs/digits/tail_de | 0.85971049 |
111 | MP0009697_abnormal_copulation | 0.85636683 |
112 | MP0002132_abnormal_respiratory_system | 0.85129474 |
113 | MP0000427_abnormal_hair_cycle | 0.85113657 |
114 | MP0005197_abnormal_uvea_morphology | 0.84305712 |
115 | MP0003646_muscle_fatigue | 0.81748629 |
116 | MP0003878_abnormal_ear_physiology | 0.79656137 |
117 | MP0005377_hearing/vestibular/ear_phenot | 0.79656137 |
118 | MP0005379_endocrine/exocrine_gland_phen | 0.79058869 |
119 | MP0000653_abnormal_sex_gland | 0.79032429 |
120 | MP0005391_vision/eye_phenotype | 0.77216104 |
121 | MP0002085_abnormal_embryonic_tissue | 0.75788417 |
122 | MP0005023_abnormal_wound_healing | 0.75252127 |
123 | MP0009053_abnormal_anal_canal | 0.75098084 |
124 | MP0001119_abnormal_female_reproductive | 0.75084659 |
125 | MP0008875_abnormal_xenobiotic_pharmacok | 0.74926124 |
126 | MP0001533_abnormal_skeleton_physiology | 0.74908007 |
127 | MP0003943_abnormal_hepatobiliary_system | 0.74804755 |
128 | MP0005551_abnormal_eye_electrophysiolog | 0.74373212 |
129 | MP0002210_abnormal_sex_determination | 0.74317286 |
130 | MP0002084_abnormal_developmental_patter | 0.74066873 |
131 | MP0000358_abnormal_cell_content/ | 0.73917048 |
132 | MP0003866_abnormal_defecation | 0.73133606 |
133 | MP0009278_abnormal_bone_marrow | 0.73028419 |
134 | MP0002638_abnormal_pupillary_reflex | 0.72784412 |
135 | MP0003718_maternal_effect | 0.72623176 |
136 | MP0001145_abnormal_male_reproductive | 0.72560959 |
137 | MP0008469_abnormal_protein_level | 0.72507032 |
138 | MP0006082_CNS_inflammation | 0.71709063 |
139 | MP0003221_abnormal_cardiomyocyte_apopto | 0.71680796 |
140 | MP0004197_abnormal_fetal_growth/weight/ | 0.71330434 |
141 | MP0002933_joint_inflammation | 0.70461101 |
142 | MP0000015_abnormal_ear_pigmentation | 0.69946141 |
143 | MP0005389_reproductive_system_phenotype | 0.68967544 |
144 | MP0000598_abnormal_liver_morphology | 0.68607422 |
145 | MP0000569_abnormal_digit_pigmentation | 0.68567199 |
146 | MP0002282_abnormal_trachea_morphology | 0.68283252 |
147 | MP0001764_abnormal_homeostasis | 0.67696381 |
148 | MP0005257_abnormal_intraocular_pressure | 0.67558618 |
149 | MP0005384_cellular_phenotype | 0.66990936 |
150 | MP0003303_peritoneal_inflammation | 0.66461391 |
151 | MP0000477_abnormal_intestine_morphology | 0.65896296 |
152 | MP0005220_abnormal_exocrine_pancreas | 0.61822496 |
153 | MP0002234_abnormal_pharynx_morphology | 0.61786608 |
154 | MP0001485_abnormal_pinna_reflex | 0.61404788 |
155 | MP0003698_abnormal_male_reproductive | 0.61089737 |
156 | MP0009672_abnormal_birth_weight | 0.60935534 |
157 | MP0003121_genomic_imprinting | 0.60435888 |
158 | MP0008872_abnormal_physiological_respon | 0.60012589 |
159 | MP0000383_abnormal_hair_follicle | 0.58676672 |
160 | MP0002697_abnormal_eye_size | 0.58669300 |
161 | MP0002111_abnormal_tail_morphology | 0.58641628 |
162 | MP0002837_dystrophic_cardiac_calcinosis | 0.57567031 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormal number of erythroid precursors (HP:0012131) | 4.29682077 |
2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.03813910 |
3 | Reticulocytopenia (HP:0001896) | 4.02495276 |
4 | Aplastic anemia (HP:0001915) | 3.89959487 |
5 | Birth length less than 3rd percentile (HP:0003561) | 3.89174588 |
6 | Acute necrotizing encephalopathy (HP:0006965) | 3.82904956 |
7 | Acute encephalopathy (HP:0006846) | 3.73262131 |
8 | Thrombocytosis (HP:0001894) | 3.61200539 |
9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.59065392 |
10 | Chromsome breakage (HP:0040012) | 3.47686453 |
11 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.39982273 |
12 | Hypoplasia of the fovea (HP:0007750) | 3.39982273 |
13 | Abnormality of the anterior horn cell (HP:0006802) | 3.35806989 |
14 | Degeneration of anterior horn cells (HP:0002398) | 3.35806989 |
15 | Aplasia/Hypoplasia of the macula (HP:0008059) | 3.25896125 |
16 | Oral leukoplakia (HP:0002745) | 3.25262656 |
17 | Increased CSF lactate (HP:0002490) | 3.17434869 |
18 | IgM deficiency (HP:0002850) | 3.16823980 |
19 | Mitochondrial inheritance (HP:0001427) | 3.16428899 |
20 | Progressive macrocephaly (HP:0004481) | 3.11615441 |
21 | Abnormality of glycolysis (HP:0004366) | 3.09485945 |
22 | Patchy hypopigmentation of hair (HP:0011365) | 3.05050038 |
23 | 11 pairs of ribs (HP:0000878) | 3.03633969 |
24 | Abnormality of chromosome stability (HP:0003220) | 3.00582199 |
25 | Agnosia (HP:0010524) | 3.00395526 |
26 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 2.99009683 |
27 | Abnormal lung lobation (HP:0002101) | 2.98709453 |
28 | Type I transferrin isoform profile (HP:0003642) | 2.98306024 |
29 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.95238634 |
30 | Abnormality of the fovea (HP:0000493) | 2.93881063 |
31 | Abnormality of methionine metabolism (HP:0010901) | 2.90566333 |
32 | Increased serum pyruvate (HP:0003542) | 2.88618700 |
33 | Colon cancer (HP:0003003) | 2.83002932 |
34 | Cerebral edema (HP:0002181) | 2.81360701 |
35 | Petechiae (HP:0000967) | 2.79969838 |
36 | White forelock (HP:0002211) | 2.73096581 |
37 | Abnormality of the preputium (HP:0100587) | 2.72485781 |
38 | Pallor (HP:0000980) | 2.71953414 |
39 | Reduced antithrombin III activity (HP:0001976) | 2.66900403 |
40 | Volvulus (HP:0002580) | 2.65927531 |
41 | Myelodysplasia (HP:0002863) | 2.65723920 |
42 | Rough bone trabeculation (HP:0100670) | 2.63898817 |
43 | Meckel diverticulum (HP:0002245) | 2.60532615 |
44 | Bone marrow hypocellularity (HP:0005528) | 2.60086273 |
45 | Premature graying of hair (HP:0002216) | 2.57403494 |
46 | Increased hepatocellular lipid droplets (HP:0006565) | 2.52594297 |
47 | Methylmalonic acidemia (HP:0002912) | 2.51367699 |
48 | Abnormality of the ileum (HP:0001549) | 2.46869884 |
49 | Macrocytic anemia (HP:0001972) | 2.46087684 |
50 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.44982424 |
51 | Pancytopenia (HP:0001876) | 2.44648714 |
52 | Lipid accumulation in hepatocytes (HP:0006561) | 2.37070840 |
53 | Selective tooth agenesis (HP:0001592) | 2.35297878 |
54 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.35208974 |
55 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.34770214 |
56 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.34026533 |
57 | Lymphoma (HP:0002665) | 2.33003359 |
58 | Small intestinal stenosis (HP:0012848) | 2.31513158 |
59 | Duodenal stenosis (HP:0100867) | 2.31513158 |
60 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.28679408 |
61 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.27385193 |
62 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.27385193 |
63 | Abnormal protein glycosylation (HP:0012346) | 2.27385193 |
64 | Abnormal glycosylation (HP:0012345) | 2.27385193 |
65 | Carpal bone hypoplasia (HP:0001498) | 2.26350367 |
66 | Embryonal renal neoplasm (HP:0011794) | 2.25839171 |
67 | Microretrognathia (HP:0000308) | 2.24489940 |
68 | Methylmalonic aciduria (HP:0012120) | 2.23945539 |
69 | Recurrent abscess formation (HP:0002722) | 2.23752717 |
70 | Cellular immunodeficiency (HP:0005374) | 2.20416581 |
71 | Abnormality of T cell physiology (HP:0011840) | 2.16521802 |
72 | Nausea (HP:0002018) | 2.13861056 |
73 | Poikiloderma (HP:0001029) | 2.12991239 |
74 | Abnormality of the prostate (HP:0008775) | 2.12320890 |
75 | Ocular albinism (HP:0001107) | 2.12240170 |
76 | Acute myeloid leukemia (HP:0004808) | 2.09498113 |
77 | Intestinal atresia (HP:0011100) | 2.08941863 |
78 | Periodontitis (HP:0000704) | 2.08206423 |
79 | Absent thumb (HP:0009777) | 2.07481031 |
80 | Lactic acidosis (HP:0003128) | 2.07374893 |
81 | Abnormality of T cells (HP:0002843) | 2.07300594 |
82 | Patellar aplasia (HP:0006443) | 2.07172980 |
83 | Respiratory failure (HP:0002878) | 2.07039068 |
84 | Chronic otitis media (HP:0000389) | 2.06765417 |
85 | Microvesicular hepatic steatosis (HP:0001414) | 2.06176037 |
86 | Recurrent viral infections (HP:0004429) | 2.05978963 |
87 | Ependymoma (HP:0002888) | 2.05485286 |
88 | Adrenal hypoplasia (HP:0000835) | 2.04876371 |
89 | Abnormality of the labia minora (HP:0012880) | 2.04075290 |
90 | Median cleft lip (HP:0000161) | 2.03878414 |
91 | Abnormality of the carotid arteries (HP:0005344) | 2.03684236 |
92 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.03388616 |
93 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.03379349 |
94 | Renal Fanconi syndrome (HP:0001994) | 2.02907056 |
95 | Iris hypopigmentation (HP:0007730) | 2.02253979 |
96 | Pulmonary fibrosis (HP:0002206) | 2.02059165 |
97 | Poor head control (HP:0002421) | 2.01318257 |
98 | Abnormal trabecular bone morphology (HP:0100671) | 2.01185584 |
99 | Abnormal auditory evoked potentials (HP:0006958) | 2.00249081 |
100 | Exercise intolerance (HP:0003546) | 1.98944854 |
101 | Facial cleft (HP:0002006) | 1.96753207 |
102 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.96567491 |
103 | Congenital stationary night blindness (HP:0007642) | 1.96060893 |
104 | Astigmatism (HP:0000483) | 1.95400822 |
105 | Hypoplasia of the pons (HP:0012110) | 1.94693527 |
106 | Hepatocellular necrosis (HP:0001404) | 1.94621362 |
107 | Triphalangeal thumb (HP:0001199) | 1.93395883 |
108 | Granulocytopenia (HP:0001913) | 1.93309847 |
109 | Irregular epiphyses (HP:0010582) | 1.92316224 |
110 | Abnormality of the duodenum (HP:0002246) | 1.92078380 |
111 | Recurrent bacterial skin infections (HP:0005406) | 1.91837037 |
112 | Bifid tongue (HP:0010297) | 1.91795141 |
113 | Beaking of vertebral bodies (HP:0004568) | 1.91687054 |
114 | Medulloblastoma (HP:0002885) | 1.91204234 |
115 | Abnormality of DNA repair (HP:0003254) | 1.90570365 |
116 | Clubbing of toes (HP:0100760) | 1.89795074 |
117 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.88889056 |
118 | Cutaneous melanoma (HP:0012056) | 1.88468608 |
119 | Increased serum lactate (HP:0002151) | 1.87563410 |
120 | Neoplasm of the pancreas (HP:0002894) | 1.87028575 |
121 | IgG deficiency (HP:0004315) | 1.86861315 |
122 | Pancreatic cysts (HP:0001737) | 1.86367468 |
123 | Abnormal platelet function (HP:0011869) | 1.86259817 |
124 | Impaired platelet aggregation (HP:0003540) | 1.86259817 |
125 | Hyperglycinemia (HP:0002154) | 1.85416330 |
126 | Horseshoe kidney (HP:0000085) | 1.85349691 |
127 | Sloping forehead (HP:0000340) | 1.85077061 |
128 | Amaurosis fugax (HP:0100576) | 1.84701181 |
129 | Megaloblastic anemia (HP:0001889) | 1.84637214 |
130 | Leukodystrophy (HP:0002415) | 1.84440148 |
131 | Abnormal number of incisors (HP:0011064) | 1.84308493 |
132 | Hepatic necrosis (HP:0002605) | 1.83975155 |
133 | Generalized hypopigmentation (HP:0007513) | 1.83156013 |
134 | CNS demyelination (HP:0007305) | 1.83092167 |
135 | Prominent nose (HP:0000448) | 1.82169640 |
136 | Slender long bone (HP:0003100) | 1.81991268 |
137 | Albinism (HP:0001022) | 1.81900358 |
138 | Abnormality of the pons (HP:0007361) | 1.81576870 |
139 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.81109587 |
140 | Abnormality of serum amino acid levels (HP:0003112) | 1.80686859 |
141 | Rhabdomyosarcoma (HP:0002859) | 1.80661800 |
142 | T lymphocytopenia (HP:0005403) | 1.79886928 |
143 | Lethargy (HP:0001254) | 1.79148415 |
144 | Breast hypoplasia (HP:0003187) | 1.79066335 |
145 | Abnormality of reticulocytes (HP:0004312) | 1.76507673 |
146 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.76321183 |
147 | Neoplasm of the adrenal gland (HP:0100631) | 1.76224731 |
148 | Myositis (HP:0100614) | 1.76212330 |
149 | Abnormality of B cell number (HP:0010975) | 1.75112239 |
150 | B lymphocytopenia (HP:0010976) | 1.75112239 |
151 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.73775838 |
152 | Long eyelashes (HP:0000527) | 1.73214908 |
153 | Tongue fasciculations (HP:0001308) | 1.73090355 |
154 | Neoplasm of the colon (HP:0100273) | 1.72787339 |
155 | Blue irides (HP:0000635) | 1.71583717 |
156 | Basal cell carcinoma (HP:0002671) | 1.71211774 |
157 | Overlapping toe (HP:0001845) | 1.70996838 |
158 | Increased nuchal translucency (HP:0010880) | 1.70981876 |
159 | Gastrointestinal atresia (HP:0002589) | 1.70477230 |
160 | Hypoplastic pelvis (HP:0008839) | 1.69960365 |
161 | Ectopic kidney (HP:0000086) | 1.69809406 |
162 | Increased serum ferritin (HP:0003281) | 1.69365272 |
163 | Severe visual impairment (HP:0001141) | 1.68847699 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WEE1 | 3.89878328 |
2 | BUB1 | 3.64762346 |
3 | EIF2AK1 | 3.60633499 |
4 | CDC7 | 3.55018904 |
5 | VRK2 | 2.93297399 |
6 | STK16 | 2.85274767 |
7 | TRIM28 | 2.74651087 |
8 | BRSK2 | 2.53926596 |
9 | VRK1 | 2.51997752 |
10 | MAP4K1 | 2.34974159 |
11 | NEK2 | 2.28738548 |
12 | EIF2AK3 | 2.27424480 |
13 | NME2 | 2.16165830 |
14 | NUAK1 | 2.14788968 |
15 | MST4 | 2.12135943 |
16 | ACVR1B | 2.10762343 |
17 | BMPR1B | 1.94460553 |
18 | SRPK1 | 1.88290600 |
19 | PIM2 | 1.88211204 |
20 | RPS6KA4 | 1.83525891 |
21 | CCNB1 | 1.75437392 |
22 | ERBB3 | 1.74267669 |
23 | STK10 | 1.71297416 |
24 | BRSK1 | 1.63661563 |
25 | PDK2 | 1.61163926 |
26 | ATR | 1.56782367 |
27 | PLK1 | 1.55290818 |
28 | TSSK6 | 1.55073372 |
29 | TTK | 1.55047174 |
30 | AURKB | 1.53675859 |
31 | TESK2 | 1.52748295 |
32 | TAF1 | 1.49957419 |
33 | BCR | 1.49345822 |
34 | CDK7 | 1.46898662 |
35 | PLK4 | 1.46779649 |
36 | MKNK1 | 1.45861228 |
37 | EEF2K | 1.45630425 |
38 | TEC | 1.44957591 |
39 | MAP4K2 | 1.43638565 |
40 | NEK1 | 1.43243689 |
41 | BTK | 1.41344693 |
42 | PASK | 1.40502052 |
43 | TLK1 | 1.37294627 |
44 | NME1 | 1.32162874 |
45 | KIT | 1.31746762 |
46 | PAK4 | 1.29648729 |
47 | IRAK4 | 1.29639378 |
48 | PLK2 | 1.27802161 |
49 | FLT3 | 1.25349718 |
50 | SCYL2 | 1.23041311 |
51 | WNK3 | 1.20996051 |
52 | PLK3 | 1.16846243 |
53 | TAOK3 | 1.16111367 |
54 | STK4 | 1.15092487 |
55 | BLK | 1.14683529 |
56 | MAP3K8 | 1.11227932 |
57 | RPS6KB2 | 1.10686460 |
58 | LMTK2 | 1.09728052 |
59 | NEK9 | 1.08487432 |
60 | KDR | 1.05558904 |
61 | TXK | 1.05407713 |
62 | ZAP70 | 1.04564183 |
63 | CDK4 | 1.03575583 |
64 | ERN1 | 1.00335135 |
65 | TGFBR1 | 0.98800969 |
66 | CSNK1G3 | 0.94957559 |
67 | MST1R | 0.93823054 |
68 | MAP2K3 | 0.92970665 |
69 | TESK1 | 0.91471763 |
70 | MARK3 | 0.90442534 |
71 | EIF2AK2 | 0.90200246 |
72 | CSNK1G1 | 0.88969292 |
73 | MKNK2 | 0.88219507 |
74 | STK39 | 0.87767385 |
75 | PKN2 | 0.86141912 |
76 | CHEK1 | 0.85427333 |
77 | JAK3 | 0.84770930 |
78 | AURKA | 0.82823219 |
79 | FRK | 0.82525262 |
80 | LATS1 | 0.82409647 |
81 | ITK | 0.81970598 |
82 | CLK1 | 0.81329446 |
83 | FER | 0.81180728 |
84 | PIM1 | 0.80487958 |
85 | CSNK1A1L | 0.78325390 |
86 | CSNK1G2 | 0.76408055 |
87 | CDK8 | 0.75837579 |
88 | CHEK2 | 0.74926623 |
89 | CSF1R | 0.74191755 |
90 | OXSR1 | 0.73950593 |
91 | LRRK2 | 0.68360346 |
92 | CDK6 | 0.67877374 |
93 | TYK2 | 0.66718591 |
94 | LYN | 0.66713914 |
95 | CDK12 | 0.64408402 |
96 | SIK3 | 0.64289669 |
97 | MAP3K12 | 0.62269660 |
98 | ATM | 0.61632270 |
99 | SYK | 0.60041043 |
100 | TBK1 | 0.59372731 |
101 | DYRK3 | 0.58618355 |
102 | CSNK2A1 | 0.58126152 |
103 | PNCK | 0.56282004 |
104 | MAP3K11 | 0.55231643 |
105 | MAP3K10 | 0.53689944 |
106 | FGFR1 | 0.52934020 |
107 | CDK2 | 0.52266732 |
108 | CSNK2A2 | 0.49439719 |
109 | ZAK | 0.47474205 |
110 | GRK1 | 0.47135957 |
111 | MELK | 0.46377435 |
112 | PRKCI | 0.46316253 |
113 | LCK | 0.44841250 |
114 | ERBB4 | 0.43971729 |
115 | PAK1 | 0.43745288 |
116 | MET | 0.43579502 |
117 | MAPKAPK5 | 0.42166479 |
118 | BCKDK | 0.40716779 |
119 | DAPK1 | 0.40170692 |
120 | MUSK | 0.39921012 |
121 | IRAK3 | 0.39267954 |
122 | CDK1 | 0.38887340 |
123 | PBK | 0.37904282 |
124 | MAPKAPK2 | 0.37474682 |
125 | BRD4 | 0.36846944 |
126 | STK3 | 0.36198096 |
127 | LIMK1 | 0.35749002 |
128 | MAP2K6 | 0.34628491 |
129 | INSRR | 0.34343762 |
130 | MAPK11 | 0.33753106 |
131 | PRKDC | 0.32228735 |
132 | STK38L | 0.30887851 |
133 | ILK | 0.30420648 |
134 | IKBKB | 0.30002830 |
135 | DYRK2 | 0.29920530 |
136 | CDK3 | 0.29154395 |
137 | RPS6KA5 | 0.28530872 |
138 | TAOK2 | 0.27883840 |
139 | PIK3CG | 0.27546951 |
140 | MINK1 | 0.27501092 |
141 | CSNK1A1 | 0.26086483 |
142 | CDK19 | 0.24530921 |
143 | WNK4 | 0.23220305 |
144 | GRK5 | 0.22791177 |
145 | BMPR2 | 0.22154562 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 5.31964092 |
2 | Mismatch repair_Homo sapiens_hsa03430 | 4.05995218 |
3 | Base excision repair_Homo sapiens_hsa03410 | 3.44794131 |
4 | Ribosome_Homo sapiens_hsa03010 | 3.18237920 |
5 | Homologous recombination_Homo sapiens_hsa03440 | 3.08482971 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.79751400 |
7 | Spliceosome_Homo sapiens_hsa03040 | 2.78043319 |
8 | Proteasome_Homo sapiens_hsa03050 | 2.77118436 |
9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67954777 |
10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.67450168 |
11 | Cell cycle_Homo sapiens_hsa04110 | 2.55835332 |
12 | RNA transport_Homo sapiens_hsa03013 | 2.41693487 |
13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.35198304 |
14 | RNA polymerase_Homo sapiens_hsa03020 | 2.26478262 |
15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.21107193 |
16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.15355534 |
17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.07181067 |
18 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.06242667 |
19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.01772193 |
20 | Parkinsons disease_Homo sapiens_hsa05012 | 1.98748617 |
21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.84521550 |
22 | RNA degradation_Homo sapiens_hsa03018 | 1.72395448 |
23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57657321 |
24 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.53353664 |
25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.52685118 |
26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.51598680 |
27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.47700294 |
28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.43689976 |
29 | Protein export_Homo sapiens_hsa03060 | 1.43411770 |
30 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.40969165 |
31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.39959764 |
32 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.38431191 |
33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.36898191 |
34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.33933409 |
35 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.33348385 |
36 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.32367337 |
37 | Basal transcription factors_Homo sapiens_hsa03022 | 1.29695764 |
38 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.25044344 |
39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.14650078 |
40 | Purine metabolism_Homo sapiens_hsa00230 | 1.13379694 |
41 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.11419870 |
42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.08073675 |
43 | * N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.06901534 |
44 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.06641808 |
45 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.06009921 |
46 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.01447908 |
47 | Legionellosis_Homo sapiens_hsa05134 | 0.98273429 |
48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.93149795 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92667950 |
50 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.91521138 |
51 | Measles_Homo sapiens_hsa05162 | 0.90893154 |
52 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.90404642 |
53 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.87329982 |
54 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.87132546 |
55 | Leishmaniasis_Homo sapiens_hsa05140 | 0.85484614 |
56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.84666663 |
57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.84503770 |
58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83356992 |
59 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.82481901 |
60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.80697915 |
61 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.80483987 |
62 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.78661033 |
63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.77210217 |
64 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.77160752 |
65 | Peroxisome_Homo sapiens_hsa04146 | 0.77043794 |
66 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.76347308 |
67 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.74641777 |
68 | Sulfur relay system_Homo sapiens_hsa04122 | 0.72922488 |
69 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.72619510 |
70 | HTLV-I infection_Homo sapiens_hsa05166 | 0.72244394 |
71 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.71852693 |
72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.71388270 |
73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.70176676 |
74 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.70172319 |
75 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.69660240 |
76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.69010044 |
77 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.64538454 |
78 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.63717701 |
79 | Hepatitis B_Homo sapiens_hsa05161 | 0.62728530 |
80 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.61829405 |
81 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61689553 |
82 | Shigellosis_Homo sapiens_hsa05131 | 0.59991786 |
83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.59867797 |
84 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.59769291 |
85 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.59318020 |
86 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.57241615 |
87 | Apoptosis_Homo sapiens_hsa04210 | 0.56622440 |
88 | Carbon metabolism_Homo sapiens_hsa01200 | 0.55722044 |
89 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55558140 |
90 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.55377391 |
91 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.53018718 |
92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.52839938 |
93 | Influenza A_Homo sapiens_hsa05164 | 0.52459782 |
94 | Thyroid cancer_Homo sapiens_hsa05216 | 0.49312072 |
95 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49169938 |
96 | Allograft rejection_Homo sapiens_hsa05330 | 0.48749855 |
97 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.48369577 |
98 | Viral myocarditis_Homo sapiens_hsa05416 | 0.46767919 |
99 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.44798223 |
100 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.44366049 |
101 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.44277543 |
102 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.43595366 |
103 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43579120 |
104 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.42829552 |
105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.42611933 |
106 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.42557998 |
107 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41836395 |
108 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.40597451 |
109 | Pertussis_Homo sapiens_hsa05133 | 0.40391407 |
110 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.38681862 |
111 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.38000583 |
112 | Asthma_Homo sapiens_hsa05310 | 0.37953875 |
113 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.37364229 |
114 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.36059505 |
115 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.35556390 |
116 | Retinol metabolism_Homo sapiens_hsa00830 | 0.35172580 |
117 | Lysine degradation_Homo sapiens_hsa00310 | 0.34754037 |
118 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.34253122 |
119 | Galactose metabolism_Homo sapiens_hsa00052 | 0.33198978 |
120 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.31742751 |
121 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.31557658 |
122 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.30647563 |
123 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.30464526 |
124 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.29546437 |
125 | Malaria_Homo sapiens_hsa05144 | 0.28819877 |
126 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.28777733 |
127 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.27717570 |
128 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.27349983 |
129 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.25678372 |
130 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.24472680 |
131 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.24318195 |
132 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.23397356 |
133 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.22513289 |
134 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.22500472 |
135 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22317957 |
136 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.21623540 |
137 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.21429539 |
138 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.20873798 |
139 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.20377038 |
140 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.20123099 |
141 | Tuberculosis_Homo sapiens_hsa05152 | 0.19429054 |
142 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.19091296 |
143 | Colorectal cancer_Homo sapiens_hsa05210 | 0.19017981 |
144 | Histidine metabolism_Homo sapiens_hsa00340 | 0.17221675 |
145 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.17012440 |
146 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.16933790 |
147 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.16090782 |
148 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.14829453 |