ALG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.19010391
2DNA strand elongation involved in DNA replication (GO:0006271)5.06059486
3telomere maintenance via semi-conservative replication (GO:0032201)4.91633135
4DNA strand elongation (GO:0022616)4.87548320
5protein localization to kinetochore (GO:0034501)4.61105693
6melanin biosynthetic process (GO:0042438)4.59173399
7DNA unwinding involved in DNA replication (GO:0006268)4.51296982
8telomere maintenance via recombination (GO:0000722)4.40323808
9mitotic metaphase plate congression (GO:0007080)4.35631103
10DNA replication initiation (GO:0006270)4.33400456
11ribosomal small subunit assembly (GO:0000028)4.28966872
12secondary metabolite biosynthetic process (GO:0044550)4.24637289
13mitotic recombination (GO:0006312)4.16647352
14protein localization to chromosome, centromeric region (GO:0071459)4.11606234
15CENP-A containing nucleosome assembly (GO:0034080)4.09812787
16DNA deamination (GO:0045006)4.09572767
17melanin metabolic process (GO:0006582)4.03466909
18metaphase plate congression (GO:0051310)3.98001273
19DNA replication checkpoint (GO:0000076)3.92078064
20chromatin remodeling at centromere (GO:0031055)3.91293350
21telomere maintenance via telomere lengthening (GO:0010833)3.91114006
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91034034
23kinetochore organization (GO:0051383)3.79965296
24nucleobase biosynthetic process (GO:0046112)3.78034245
25mitotic nuclear envelope disassembly (GO:0007077)3.75652084
26negative regulation of ligase activity (GO:0051352)3.75295185
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75295185
28DNA double-strand break processing (GO:0000729)3.71987898
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.67477418
30IMP biosynthetic process (GO:0006188)3.62368737
31regulation of cellular amino acid metabolic process (GO:0006521)3.59451509
32DNA ligation (GO:0006266)3.58175566
33establishment of chromosome localization (GO:0051303)3.57660906
34DNA replication-independent nucleosome assembly (GO:0006336)3.57540338
35DNA replication-independent nucleosome organization (GO:0034724)3.57540338
36meiotic chromosome segregation (GO:0045132)3.56466244
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54968300
38cullin deneddylation (GO:0010388)3.54231014
39spindle checkpoint (GO:0031577)3.51836061
40establishment of integrated proviral latency (GO:0075713)3.51069064
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49180244
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47317737
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47317737
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47317737
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45855969
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45855969
47regulation of spindle organization (GO:0090224)3.43539465
48nuclear envelope disassembly (GO:0051081)3.40512690
49membrane disassembly (GO:0030397)3.40512690
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40159068
51maturation of SSU-rRNA (GO:0030490)3.39185515
52mitotic sister chromatid segregation (GO:0000070)3.38763706
53regulation of DNA endoreduplication (GO:0032875)3.38176667
54purine nucleobase biosynthetic process (GO:0009113)3.37452828
55formation of translation preinitiation complex (GO:0001731)3.36556308
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36487449
57signal transduction involved in DNA damage checkpoint (GO:0072422)3.36487449
58mitotic chromosome condensation (GO:0007076)3.36433075
59mitotic spindle checkpoint (GO:0071174)3.36393167
60viral transcription (GO:0019083)3.36189987
61translational termination (GO:0006415)3.35346387
62regulation of mitochondrial translation (GO:0070129)3.34905326
63protein deneddylation (GO:0000338)3.34616152
64regulation of mitotic spindle checkpoint (GO:1903504)3.34596095
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34596095
66IMP metabolic process (GO:0046040)3.34299510
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.32859258
68kinetochore assembly (GO:0051382)3.31703145
69attachment of spindle microtubules to kinetochore (GO:0008608)3.30690394
70replication fork processing (GO:0031297)3.30374431
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29444441
72histone-serine phosphorylation (GO:0035404)3.26810993
73double-strand break repair via nonhomologous end joining (GO:0006303)3.24832272
74non-recombinational repair (GO:0000726)3.24832272
75maturation of 5.8S rRNA (GO:0000460)3.24272615
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.24047788
77negative regulation of sister chromatid segregation (GO:0033046)3.24047788
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24047788
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24047788
80negative regulation of chromosome segregation (GO:0051985)3.22699957
81DNA catabolic process, exonucleolytic (GO:0000738)3.22590148
82folic acid-containing compound biosynthetic process (GO:0009396)3.20867367
83histone exchange (GO:0043486)3.17552091
84sister chromatid segregation (GO:0000819)3.16635557
85resolution of meiotic recombination intermediates (GO:0000712)3.15801330
86ribosomal large subunit biogenesis (GO:0042273)3.15429392
87translesion synthesis (GO:0019985)3.14832770
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14273675
89positive regulation of ligase activity (GO:0051351)3.13985212
90mitotic spindle assembly checkpoint (GO:0007094)3.12648952
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12415914
92spindle assembly checkpoint (GO:0071173)3.11160735
93telomere organization (GO:0032200)3.10662375
94regulation of ubiquitin-protein transferase activity (GO:0051438)3.10430867
95telomere maintenance (GO:0000723)3.10351822
96translational elongation (GO:0006414)3.09080590
97pseudouridine synthesis (GO:0001522)3.08002123
98synapsis (GO:0007129)3.07324096
99cotranslational protein targeting to membrane (GO:0006613)3.04978494
100chaperone-mediated protein transport (GO:0072321)3.04767838
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03297104
102mitochondrial respiratory chain complex assembly (GO:0033108)3.02816413
103mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02774658
104protein targeting to ER (GO:0045047)3.02102551
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.01604890
106protein complex biogenesis (GO:0070271)3.00727877
107negative regulation of RNA splicing (GO:0033119)3.00689254
108regulation of chromosome segregation (GO:0051983)3.00598515
109histone mRNA metabolic process (GO:0008334)3.00512292
110translational initiation (GO:0006413)2.98728985
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98659414
112regulation of ligase activity (GO:0051340)2.98171783
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97148484
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97148484
115establishment of protein localization to mitochondrial membrane (GO:0090151)2.95028037
116respiratory chain complex IV assembly (GO:0008535)2.94975003
117L-serine metabolic process (GO:0006563)2.90724601
118mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90362540
119regulation of mitotic sister chromatid segregation (GO:0033047)2.87578298
120base-excision repair (GO:0006284)2.86706542
121deoxyribonucleotide biosynthetic process (GO:0009263)2.86542442
122ribonucleoprotein complex biogenesis (GO:0022613)2.86172254
123establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85164105
124protein localization to endoplasmic reticulum (GO:0070972)2.84538918
125DNA replication-dependent nucleosome assembly (GO:0006335)2.84354961
126DNA replication-dependent nucleosome organization (GO:0034723)2.84354961
127ribosome biogenesis (GO:0042254)2.82976985
128postreplication repair (GO:0006301)2.82603102
129DNA duplex unwinding (GO:0032508)2.82074743
130DNA geometric change (GO:0032392)2.80917346
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80682016
132spliceosomal snRNP assembly (GO:0000387)2.79100296
133mitotic sister chromatid cohesion (GO:0007064)2.77358008
134protein localization to chromosome (GO:0034502)2.76167640
135cell cycle G1/S phase transition (GO:0044843)2.76073312
136G1/S transition of mitotic cell cycle (GO:0000082)2.76073312
137regulation of mitotic spindle organization (GO:0060236)2.74554680
138chromosome segregation (GO:0007059)2.74447313
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72180973
140ribosomal small subunit biogenesis (GO:0042274)2.71997219
141DNA topological change (GO:0006265)2.69497609
142mismatch repair (GO:0006298)2.69037345
143rRNA processing (GO:0006364)2.68757260
144transcription-coupled nucleotide-excision repair (GO:0006283)2.66320074
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66015080
146DNA-dependent DNA replication (GO:0006261)2.65714224
147nuclear pore organization (GO:0006999)2.65403871
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63578024
149ribosome assembly (GO:0042255)2.63107956
150nuclear envelope organization (GO:0006998)2.62801376
151DNA conformation change (GO:0071103)2.61936422
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.61858881
153cellular protein complex disassembly (GO:0043624)2.61773214
154regulation of double-strand break repair via homologous recombination (GO:0010569)2.60992513
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59713939
156chromatin assembly or disassembly (GO:0006333)2.59058268
157negative regulation of mRNA processing (GO:0050686)2.58465635
158rRNA metabolic process (GO:0016072)2.57619198
159translation (GO:0006412)2.57377758
160viral life cycle (GO:0019058)2.57344976
161mitotic cell cycle (GO:0000278)2.57339395
162negative regulation of mitotic sister chromatid segregation (GO:0033048)2.56414895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.87054266
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24939097
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.83215493
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78017723
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66165924
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21688490
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13353389
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05508134
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.82544882
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.69140545
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63769446
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61908168
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53242063
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47610531
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.47283504
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38544230
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37856374
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30184416
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.30024274
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25243802
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24137258
22AR_21909140_ChIP-Seq_LNCAP_Human2.15532234
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15381318
24VDR_23849224_ChIP-Seq_CD4+_Human2.13775878
25XRN2_22483619_ChIP-Seq_HELA_Human2.10045439
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08992391
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04471053
28* E2F1_21310950_ChIP-Seq_MCF-7_Human2.00585084
29FOXP3_21729870_ChIP-Seq_TREG_Human1.99391591
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96991382
31DCP1A_22483619_ChIP-Seq_HELA_Human1.96042802
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.87566182
33MYC_22102868_ChIP-Seq_BL_Human1.78832901
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78136176
35* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77008266
36* GABP_19822575_ChIP-Seq_HepG2_Human1.76194498
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72374542
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71667577
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69033867
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68524407
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66974023
42CIITA_25753668_ChIP-Seq_RAJI_Human1.63904491
43* TTF2_22483619_ChIP-Seq_HELA_Human1.63674181
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62900807
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62495661
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61945041
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61797682
48ELK1_19687146_ChIP-ChIP_HELA_Human1.60905100
49* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58519026
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58325277
51EWS_26573619_Chip-Seq_HEK293_Human1.51641403
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.51111322
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51027198
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49250893
55SPI1_23547873_ChIP-Seq_NB4_Human1.47032376
56VDR_21846776_ChIP-Seq_THP-1_Human1.44679731
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43625605
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40240378
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40097123
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39596632
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39415550
62* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34535557
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.32297484
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.30838675
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30264676
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29534409
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.29309233
68KDM5A_27292631_Chip-Seq_BREAST_Human1.28815796
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28114854
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26422115
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.25172670
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24472118
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21854453
74FUS_26573619_Chip-Seq_HEK293_Human1.21731665
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20331033
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20068988
77* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19282679
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18893836
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14733407
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13267736
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12482454
82TFEB_21752829_ChIP-Seq_HELA_Human1.11176404
83ZNF274_21170338_ChIP-Seq_K562_Hela1.10238593
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09832922
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08677741
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08410664
87SCL_19346495_ChIP-Seq_HPC-7_Human1.06757784
88VDR_22108803_ChIP-Seq_LS180_Human1.06222216
89MYB_26560356_Chip-Seq_TH2_Human1.05012531
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.03258090
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.01397547
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99716386
93MYB_26560356_Chip-Seq_TH1_Human0.98914283
94RUNX1_22412390_ChIP-Seq_EML_Mouse0.98785237
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97546750
96MYC_18940864_ChIP-ChIP_HL60_Human0.97334209
97BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94712099
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93751520
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93003527
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92761184
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92731767
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.92222505
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91687704
104GATA1_22025678_ChIP-Seq_K562_Human0.90061922
105UTX_26944678_Chip-Seq_JUKART_Human0.89797447
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89219558
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87754380
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86869614
109MAF_26560356_Chip-Seq_TH1_Human0.86752632
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84576292
111VDR_24763502_ChIP-Seq_THP-1_Human0.84498905
112* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84272431
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83802990
114IGF1R_20145208_ChIP-Seq_DFB_Human0.83415824
115* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83264873
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82258241
117IRF1_19129219_ChIP-ChIP_H3396_Human0.81924463
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81821009
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81771746
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80725129
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80591454
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79656649
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.79082464
124ELF5_23300383_ChIP-Seq_T47D_Human0.78636283
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76395582
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71265913
127P300_19829295_ChIP-Seq_ESCs_Human0.71136978
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.70843604
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66206023
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.63982392
131* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.61249617
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.61024843
133EGR1_23403033_ChIP-Seq_LIVER_Mouse0.59559032
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.58968393
135TP53_22573176_ChIP-Seq_HFKS_Human0.58146276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.89474181
2MP0003693_abnormal_embryo_hatching4.78984881
3MP0010094_abnormal_chromosome_stability4.26519786
4MP0005408_hypopigmentation4.15495317
5MP0003111_abnormal_nucleus_morphology3.73902884
6MP0002396_abnormal_hematopoietic_system3.55979324
7MP0004957_abnormal_blastocyst_morpholog3.55571255
8MP0003136_yellow_coat_color3.48421399
9MP0005171_absent_coat_pigmentation3.43403226
10MP0003077_abnormal_cell_cycle3.38184623
11MP0008057_abnormal_DNA_replication3.11446449
12MP0008058_abnormal_DNA_repair2.68129592
13MP0002938_white_spotting2.67436315
14MP0008007_abnormal_cellular_replicative2.49833770
15MP0006054_spinal_hemorrhage2.46451928
16MP0002102_abnormal_ear_morphology2.26587945
17MP0001835_abnormal_antigen_presentation2.17886795
18MP0004808_abnormal_hematopoietic_stem2.17783476
19MP0000490_abnormal_crypts_of2.17737362
20MP0008932_abnormal_embryonic_tissue2.00013858
21MP0009333_abnormal_splenocyte_physiolog1.93811057
22MP0003763_abnormal_thymus_physiology1.92106393
23MP0001545_abnormal_hematopoietic_system1.77282640
24MP0005397_hematopoietic_system_phenotyp1.77282640
25MP0002398_abnormal_bone_marrow1.76647300
26MP0000371_diluted_coat_color1.69656500
27MP0000350_abnormal_cell_proliferation1.68601342
28MP0005671_abnormal_response_to1.67376314
29MP0001324_abnormal_eye_pigmentation1.66955392
30MP0001730_embryonic_growth_arrest1.61777242
31MP0008877_abnormal_DNA_methylation1.58388876
32MP0000689_abnormal_spleen_morphology1.57153227
33MP0002722_abnormal_immune_system1.56681363
34MP0002090_abnormal_vision1.55651066
35MP0010352_gastrointestinal_tract_polyps1.53787593
36MP0006292_abnormal_olfactory_placode1.53673988
37MP0002019_abnormal_tumor_incidence1.53306523
38MP0003436_decreased_susceptibility_to1.51746142
39MP0001800_abnormal_humoral_immune1.48543424
40MP0001853_heart_inflammation1.47502456
41MP0000703_abnormal_thymus_morphology1.44947270
42MP0010307_abnormal_tumor_latency1.44807591
43MP0002429_abnormal_blood_cell1.43588121
44MP0009785_altered_susceptibility_to1.43236916
45MP0003890_abnormal_embryonic-extraembry1.42994166
46MP0004147_increased_porphyrin_level1.42938744
47MP0002452_abnormal_antigen_presenting1.42363988
48MP0001293_anophthalmia1.42210150
49MP0005025_abnormal_response_to1.40893076
50MP0000716_abnormal_immune_system1.40157480
51MP0000858_altered_metastatic_potential1.39538010
52MP0002420_abnormal_adaptive_immunity1.39152102
53MP0000313_abnormal_cell_death1.38516061
54MP0001819_abnormal_immune_cell1.36882352
55MP0000685_abnormal_immune_system1.36731302
56MP0002877_abnormal_melanocyte_morpholog1.36215717
57MP0006036_abnormal_mitochondrial_physio1.35457712
58MP0005464_abnormal_platelet_physiology1.35042530
59MP0003656_abnormal_erythrocyte_physiolo1.33986849
60MP0002419_abnormal_innate_immunity1.33377327
61MP0000465_gastrointestinal_hemorrhage1.32430589
62MP0005075_abnormal_melanosome_morpholog1.30432636
63MP0002723_abnormal_immune_serum1.28340013
64MP0006072_abnormal_retinal_apoptosis1.27761442
65MP0005000_abnormal_immune_tolerance1.27532630
66MP0003786_premature_aging1.26656697
67MP0001529_abnormal_vocalization1.22771646
68MP0005253_abnormal_eye_physiology1.22485779
69MP0002075_abnormal_coat/hair_pigmentati1.21228899
70MP0002080_prenatal_lethality1.20184736
71MP0003186_abnormal_redox_activity1.20119653
72MP0003123_paternal_imprinting1.19709620
73MP0004381_abnormal_hair_follicle1.17690995
74MP0001697_abnormal_embryo_size1.17314419
75MP0003806_abnormal_nucleotide_metabolis1.16741964
76MP0002166_altered_tumor_susceptibility1.16465508
77MP0002405_respiratory_system_inflammati1.16130232
78MP0003195_calcinosis1.14778731
79MP0005248_abnormal_Harderian_gland1.13862748
80MP0010030_abnormal_orbit_morphology1.13576148
81MP0005174_abnormal_tail_pigmentation1.13470976
82MP0001186_pigmentation_phenotype1.13068836
83MP0010155_abnormal_intestine_physiology1.11889526
84MP0001672_abnormal_embryogenesis/_devel1.11572717
85MP0005380_embryogenesis_phenotype1.11572717
86MP0002148_abnormal_hypersensitivity_rea1.11309553
87MP0003984_embryonic_growth_retardation1.09337534
88MP0003941_abnormal_skin_development1.05243415
89MP0006035_abnormal_mitochondrial_morpho1.05100072
90MP0002088_abnormal_embryonic_growth/wei1.04975022
91MP0002095_abnormal_skin_pigmentation1.04097022
92MP0000647_abnormal_sebaceous_gland1.02561627
93MP0001929_abnormal_gametogenesis0.98580709
94MP0002006_tumorigenesis0.97048800
95MP0005076_abnormal_cell_differentiation0.97007925
96MP0008789_abnormal_olfactory_epithelium0.96745975
97MP0003567_abnormal_fetal_cardiomyocyte0.96670946
98MP0002163_abnormal_gland_morphology0.95536969
99MP0001845_abnormal_inflammatory_respons0.93889392
100MP0002086_abnormal_extraembryonic_tissu0.93464787
101MP0001873_stomach_inflammation0.92798090
102MP0001915_intracranial_hemorrhage0.92208727
103MP0003724_increased_susceptibility_to0.91928491
104MP0002233_abnormal_nose_morphology0.91820362
105MP0003172_abnormal_lysosome_physiology0.91215730
106MP0001790_abnormal_immune_system0.90056941
107MP0005387_immune_system_phenotype0.90056941
108MP0005395_other_phenotype0.87486975
109MP0002160_abnormal_reproductive_system0.86747668
110MP0003937_abnormal_limbs/digits/tail_de0.85971049
111MP0009697_abnormal_copulation0.85636683
112MP0002132_abnormal_respiratory_system0.85129474
113MP0000427_abnormal_hair_cycle0.85113657
114MP0005197_abnormal_uvea_morphology0.84305712
115MP0003646_muscle_fatigue0.81748629
116MP0003878_abnormal_ear_physiology0.79656137
117MP0005377_hearing/vestibular/ear_phenot0.79656137
118MP0005379_endocrine/exocrine_gland_phen0.79058869
119MP0000653_abnormal_sex_gland0.79032429
120MP0005391_vision/eye_phenotype0.77216104
121MP0002085_abnormal_embryonic_tissue0.75788417
122MP0005023_abnormal_wound_healing0.75252127
123MP0009053_abnormal_anal_canal0.75098084
124MP0001119_abnormal_female_reproductive0.75084659
125MP0008875_abnormal_xenobiotic_pharmacok0.74926124
126MP0001533_abnormal_skeleton_physiology0.74908007
127MP0003943_abnormal_hepatobiliary_system0.74804755
128MP0005551_abnormal_eye_electrophysiolog0.74373212
129MP0002210_abnormal_sex_determination0.74317286
130MP0002084_abnormal_developmental_patter0.74066873
131MP0000358_abnormal_cell_content/0.73917048
132MP0003866_abnormal_defecation0.73133606
133MP0009278_abnormal_bone_marrow0.73028419
134MP0002638_abnormal_pupillary_reflex0.72784412
135MP0003718_maternal_effect0.72623176
136MP0001145_abnormal_male_reproductive0.72560959
137MP0008469_abnormal_protein_level0.72507032
138MP0006082_CNS_inflammation0.71709063
139MP0003221_abnormal_cardiomyocyte_apopto0.71680796
140MP0004197_abnormal_fetal_growth/weight/0.71330434
141MP0002933_joint_inflammation0.70461101
142MP0000015_abnormal_ear_pigmentation0.69946141
143MP0005389_reproductive_system_phenotype0.68967544
144MP0000598_abnormal_liver_morphology0.68607422
145MP0000569_abnormal_digit_pigmentation0.68567199
146MP0002282_abnormal_trachea_morphology0.68283252
147MP0001764_abnormal_homeostasis0.67696381
148MP0005257_abnormal_intraocular_pressure0.67558618
149MP0005384_cellular_phenotype0.66990936
150MP0003303_peritoneal_inflammation0.66461391
151MP0000477_abnormal_intestine_morphology0.65896296
152MP0005220_abnormal_exocrine_pancreas0.61822496
153MP0002234_abnormal_pharynx_morphology0.61786608
154MP0001485_abnormal_pinna_reflex0.61404788
155MP0003698_abnormal_male_reproductive0.61089737
156MP0009672_abnormal_birth_weight0.60935534
157MP0003121_genomic_imprinting0.60435888
158MP0008872_abnormal_physiological_respon0.60012589
159MP0000383_abnormal_hair_follicle0.58676672
160MP0002697_abnormal_eye_size0.58669300
161MP0002111_abnormal_tail_morphology0.58641628
162MP0002837_dystrophic_cardiac_calcinosis0.57567031

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.29682077
2Abnormality of cells of the erythroid lineage (HP:0012130)4.03813910
3Reticulocytopenia (HP:0001896)4.02495276
4Aplastic anemia (HP:0001915)3.89959487
5Birth length less than 3rd percentile (HP:0003561)3.89174588
6Acute necrotizing encephalopathy (HP:0006965)3.82904956
7Acute encephalopathy (HP:0006846)3.73262131
8Thrombocytosis (HP:0001894)3.61200539
9Abnormal mitochondria in muscle tissue (HP:0008316)3.59065392
10Chromsome breakage (HP:0040012)3.47686453
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.39982273
12Hypoplasia of the fovea (HP:0007750)3.39982273
13Abnormality of the anterior horn cell (HP:0006802)3.35806989
14Degeneration of anterior horn cells (HP:0002398)3.35806989
15Aplasia/Hypoplasia of the macula (HP:0008059)3.25896125
16Oral leukoplakia (HP:0002745)3.25262656
17Increased CSF lactate (HP:0002490)3.17434869
18IgM deficiency (HP:0002850)3.16823980
19Mitochondrial inheritance (HP:0001427)3.16428899
20Progressive macrocephaly (HP:0004481)3.11615441
21Abnormality of glycolysis (HP:0004366)3.09485945
22Patchy hypopigmentation of hair (HP:0011365)3.05050038
2311 pairs of ribs (HP:0000878)3.03633969
24Abnormality of chromosome stability (HP:0003220)3.00582199
25Agnosia (HP:0010524)3.00395526
26Aplasia/Hypoplasia affecting the retina (HP:0008061)2.99009683
27Abnormal lung lobation (HP:0002101)2.98709453
28Type I transferrin isoform profile (HP:0003642)2.98306024
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95238634
30Abnormality of the fovea (HP:0000493)2.93881063
31Abnormality of methionine metabolism (HP:0010901)2.90566333
32Increased serum pyruvate (HP:0003542)2.88618700
33Colon cancer (HP:0003003)2.83002932
34Cerebral edema (HP:0002181)2.81360701
35Petechiae (HP:0000967)2.79969838
36White forelock (HP:0002211)2.73096581
37Abnormality of the preputium (HP:0100587)2.72485781
38Pallor (HP:0000980)2.71953414
39Reduced antithrombin III activity (HP:0001976)2.66900403
40Volvulus (HP:0002580)2.65927531
41Myelodysplasia (HP:0002863)2.65723920
42Rough bone trabeculation (HP:0100670)2.63898817
43Meckel diverticulum (HP:0002245)2.60532615
44Bone marrow hypocellularity (HP:0005528)2.60086273
45Premature graying of hair (HP:0002216)2.57403494
46Increased hepatocellular lipid droplets (HP:0006565)2.52594297
47Methylmalonic acidemia (HP:0002912)2.51367699
48Abnormality of the ileum (HP:0001549)2.46869884
49Macrocytic anemia (HP:0001972)2.46087684
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.44982424
51Pancytopenia (HP:0001876)2.44648714
52Lipid accumulation in hepatocytes (HP:0006561)2.37070840
53Selective tooth agenesis (HP:0001592)2.35297878
54Nephroblastoma (Wilms tumor) (HP:0002667)2.35208974
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.34770214
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34026533
57Lymphoma (HP:0002665)2.33003359
58Small intestinal stenosis (HP:0012848)2.31513158
59Duodenal stenosis (HP:0100867)2.31513158
60Elevated erythrocyte sedimentation rate (HP:0003565)2.28679408
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27385193
62Abnormal protein N-linked glycosylation (HP:0012347)2.27385193
63Abnormal protein glycosylation (HP:0012346)2.27385193
64Abnormal glycosylation (HP:0012345)2.27385193
65Carpal bone hypoplasia (HP:0001498)2.26350367
66Embryonal renal neoplasm (HP:0011794)2.25839171
67Microretrognathia (HP:0000308)2.24489940
68Methylmalonic aciduria (HP:0012120)2.23945539
69Recurrent abscess formation (HP:0002722)2.23752717
70Cellular immunodeficiency (HP:0005374)2.20416581
71Abnormality of T cell physiology (HP:0011840)2.16521802
72Nausea (HP:0002018)2.13861056
73Poikiloderma (HP:0001029)2.12991239
74Abnormality of the prostate (HP:0008775)2.12320890
75Ocular albinism (HP:0001107)2.12240170
76Acute myeloid leukemia (HP:0004808)2.09498113
77Intestinal atresia (HP:0011100)2.08941863
78Periodontitis (HP:0000704)2.08206423
79Absent thumb (HP:0009777)2.07481031
80Lactic acidosis (HP:0003128)2.07374893
81Abnormality of T cells (HP:0002843)2.07300594
82Patellar aplasia (HP:0006443)2.07172980
83Respiratory failure (HP:0002878)2.07039068
84Chronic otitis media (HP:0000389)2.06765417
85Microvesicular hepatic steatosis (HP:0001414)2.06176037
86Recurrent viral infections (HP:0004429)2.05978963
87Ependymoma (HP:0002888)2.05485286
88Adrenal hypoplasia (HP:0000835)2.04876371
89Abnormality of the labia minora (HP:0012880)2.04075290
90Median cleft lip (HP:0000161)2.03878414
91Abnormality of the carotid arteries (HP:0005344)2.03684236
92Abnormality of pyrimidine metabolism (HP:0004353)2.03388616
93Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03379349
94Renal Fanconi syndrome (HP:0001994)2.02907056
95Iris hypopigmentation (HP:0007730)2.02253979
96Pulmonary fibrosis (HP:0002206)2.02059165
97Poor head control (HP:0002421)2.01318257
98Abnormal trabecular bone morphology (HP:0100671)2.01185584
99Abnormal auditory evoked potentials (HP:0006958)2.00249081
100Exercise intolerance (HP:0003546)1.98944854
101Facial cleft (HP:0002006)1.96753207
102Pancreatic islet-cell hyperplasia (HP:0004510)1.96567491
103Congenital stationary night blindness (HP:0007642)1.96060893
104Astigmatism (HP:0000483)1.95400822
105Hypoplasia of the pons (HP:0012110)1.94693527
106Hepatocellular necrosis (HP:0001404)1.94621362
107Triphalangeal thumb (HP:0001199)1.93395883
108Granulocytopenia (HP:0001913)1.93309847
109Irregular epiphyses (HP:0010582)1.92316224
110Abnormality of the duodenum (HP:0002246)1.92078380
111Recurrent bacterial skin infections (HP:0005406)1.91837037
112Bifid tongue (HP:0010297)1.91795141
113Beaking of vertebral bodies (HP:0004568)1.91687054
114Medulloblastoma (HP:0002885)1.91204234
115Abnormality of DNA repair (HP:0003254)1.90570365
116Clubbing of toes (HP:0100760)1.89795074
117Aplasia/Hypoplasia of the patella (HP:0006498)1.88889056
118Cutaneous melanoma (HP:0012056)1.88468608
119Increased serum lactate (HP:0002151)1.87563410
120Neoplasm of the pancreas (HP:0002894)1.87028575
121IgG deficiency (HP:0004315)1.86861315
122Pancreatic cysts (HP:0001737)1.86367468
123Abnormal platelet function (HP:0011869)1.86259817
124Impaired platelet aggregation (HP:0003540)1.86259817
125Hyperglycinemia (HP:0002154)1.85416330
126Horseshoe kidney (HP:0000085)1.85349691
127Sloping forehead (HP:0000340)1.85077061
128Amaurosis fugax (HP:0100576)1.84701181
129Megaloblastic anemia (HP:0001889)1.84637214
130Leukodystrophy (HP:0002415)1.84440148
131Abnormal number of incisors (HP:0011064)1.84308493
132Hepatic necrosis (HP:0002605)1.83975155
133Generalized hypopigmentation (HP:0007513)1.83156013
134CNS demyelination (HP:0007305)1.83092167
135Prominent nose (HP:0000448)1.82169640
136Slender long bone (HP:0003100)1.81991268
137Albinism (HP:0001022)1.81900358
138Abnormality of the pons (HP:0007361)1.81576870
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81109587
140Abnormality of serum amino acid levels (HP:0003112)1.80686859
141Rhabdomyosarcoma (HP:0002859)1.80661800
142T lymphocytopenia (HP:0005403)1.79886928
143Lethargy (HP:0001254)1.79148415
144Breast hypoplasia (HP:0003187)1.79066335
145Abnormality of reticulocytes (HP:0004312)1.76507673
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.76321183
147Neoplasm of the adrenal gland (HP:0100631)1.76224731
148Myositis (HP:0100614)1.76212330
149Abnormality of B cell number (HP:0010975)1.75112239
150B lymphocytopenia (HP:0010976)1.75112239
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.73775838
152Long eyelashes (HP:0000527)1.73214908
153Tongue fasciculations (HP:0001308)1.73090355
154Neoplasm of the colon (HP:0100273)1.72787339
155Blue irides (HP:0000635)1.71583717
156Basal cell carcinoma (HP:0002671)1.71211774
157Overlapping toe (HP:0001845)1.70996838
158Increased nuchal translucency (HP:0010880)1.70981876
159Gastrointestinal atresia (HP:0002589)1.70477230
160Hypoplastic pelvis (HP:0008839)1.69960365
161Ectopic kidney (HP:0000086)1.69809406
162Increased serum ferritin (HP:0003281)1.69365272
163Severe visual impairment (HP:0001141)1.68847699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.89878328
2BUB13.64762346
3EIF2AK13.60633499
4CDC73.55018904
5VRK22.93297399
6STK162.85274767
7TRIM282.74651087
8BRSK22.53926596
9VRK12.51997752
10MAP4K12.34974159
11NEK22.28738548
12EIF2AK32.27424480
13NME22.16165830
14NUAK12.14788968
15MST42.12135943
16ACVR1B2.10762343
17BMPR1B1.94460553
18SRPK11.88290600
19PIM21.88211204
20RPS6KA41.83525891
21CCNB11.75437392
22ERBB31.74267669
23STK101.71297416
24BRSK11.63661563
25PDK21.61163926
26ATR1.56782367
27PLK11.55290818
28TSSK61.55073372
29TTK1.55047174
30AURKB1.53675859
31TESK21.52748295
32TAF11.49957419
33BCR1.49345822
34CDK71.46898662
35PLK41.46779649
36MKNK11.45861228
37EEF2K1.45630425
38TEC1.44957591
39MAP4K21.43638565
40NEK11.43243689
41BTK1.41344693
42PASK1.40502052
43TLK11.37294627
44NME11.32162874
45KIT1.31746762
46PAK41.29648729
47IRAK41.29639378
48PLK21.27802161
49FLT31.25349718
50SCYL21.23041311
51WNK31.20996051
52PLK31.16846243
53TAOK31.16111367
54STK41.15092487
55BLK1.14683529
56MAP3K81.11227932
57RPS6KB21.10686460
58LMTK21.09728052
59NEK91.08487432
60KDR1.05558904
61TXK1.05407713
62ZAP701.04564183
63CDK41.03575583
64ERN11.00335135
65TGFBR10.98800969
66CSNK1G30.94957559
67MST1R0.93823054
68MAP2K30.92970665
69TESK10.91471763
70MARK30.90442534
71EIF2AK20.90200246
72CSNK1G10.88969292
73MKNK20.88219507
74STK390.87767385
75PKN20.86141912
76CHEK10.85427333
77JAK30.84770930
78AURKA0.82823219
79FRK0.82525262
80LATS10.82409647
81ITK0.81970598
82CLK10.81329446
83FER0.81180728
84PIM10.80487958
85CSNK1A1L0.78325390
86CSNK1G20.76408055
87CDK80.75837579
88CHEK20.74926623
89CSF1R0.74191755
90OXSR10.73950593
91LRRK20.68360346
92CDK60.67877374
93TYK20.66718591
94LYN0.66713914
95CDK120.64408402
96SIK30.64289669
97MAP3K120.62269660
98ATM0.61632270
99SYK0.60041043
100TBK10.59372731
101DYRK30.58618355
102CSNK2A10.58126152
103PNCK0.56282004
104MAP3K110.55231643
105MAP3K100.53689944
106FGFR10.52934020
107CDK20.52266732
108CSNK2A20.49439719
109ZAK0.47474205
110GRK10.47135957
111MELK0.46377435
112PRKCI0.46316253
113LCK0.44841250
114ERBB40.43971729
115PAK10.43745288
116MET0.43579502
117MAPKAPK50.42166479
118BCKDK0.40716779
119DAPK10.40170692
120MUSK0.39921012
121IRAK30.39267954
122CDK10.38887340
123PBK0.37904282
124MAPKAPK20.37474682
125BRD40.36846944
126STK30.36198096
127LIMK10.35749002
128MAP2K60.34628491
129INSRR0.34343762
130MAPK110.33753106
131PRKDC0.32228735
132STK38L0.30887851
133ILK0.30420648
134IKBKB0.30002830
135DYRK20.29920530
136CDK30.29154395
137RPS6KA50.28530872
138TAOK20.27883840
139PIK3CG0.27546951
140MINK10.27501092
141CSNK1A10.26086483
142CDK190.24530921
143WNK40.23220305
144GRK50.22791177
145BMPR20.22154562

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31964092
2Mismatch repair_Homo sapiens_hsa034304.05995218
3Base excision repair_Homo sapiens_hsa034103.44794131
4Ribosome_Homo sapiens_hsa030103.18237920
5Homologous recombination_Homo sapiens_hsa034403.08482971
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79751400
7Spliceosome_Homo sapiens_hsa030402.78043319
8Proteasome_Homo sapiens_hsa030502.77118436
9Nucleotide excision repair_Homo sapiens_hsa034202.67954777
10One carbon pool by folate_Homo sapiens_hsa006702.67450168
11Cell cycle_Homo sapiens_hsa041102.55835332
12RNA transport_Homo sapiens_hsa030132.41693487
13Pyrimidine metabolism_Homo sapiens_hsa002402.35198304
14RNA polymerase_Homo sapiens_hsa030202.26478262
15Oxidative phosphorylation_Homo sapiens_hsa001902.21107193
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15355534
17Fanconi anemia pathway_Homo sapiens_hsa034602.07181067
18Fatty acid elongation_Homo sapiens_hsa000622.06242667
19Non-homologous end-joining_Homo sapiens_hsa034502.01772193
20Parkinsons disease_Homo sapiens_hsa050121.98748617
21Propanoate metabolism_Homo sapiens_hsa006401.84521550
22RNA degradation_Homo sapiens_hsa030181.72395448
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57657321
24p53 signaling pathway_Homo sapiens_hsa041151.53353664
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52685118
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51598680
27Pyruvate metabolism_Homo sapiens_hsa006201.47700294
28Huntingtons disease_Homo sapiens_hsa050161.43689976
29Protein export_Homo sapiens_hsa030601.43411770
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40969165
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39959764
32Steroid biosynthesis_Homo sapiens_hsa001001.38431191
33Pentose phosphate pathway_Homo sapiens_hsa000301.36898191
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33933409
35Antigen processing and presentation_Homo sapiens_hsa046121.33348385
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32367337
37Basal transcription factors_Homo sapiens_hsa030221.29695764
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25044344
39Alzheimers disease_Homo sapiens_hsa050101.14650078
40Purine metabolism_Homo sapiens_hsa002301.13379694
41Herpes simplex infection_Homo sapiens_hsa051681.11419870
42Primary immunodeficiency_Homo sapiens_hsa053401.08073675
43* N-Glycan biosynthesis_Homo sapiens_hsa005101.06901534
44mRNA surveillance pathway_Homo sapiens_hsa030151.06641808
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06009921
46Folate biosynthesis_Homo sapiens_hsa007901.01447908
47Legionellosis_Homo sapiens_hsa051340.98273429
48Selenocompound metabolism_Homo sapiens_hsa004500.93149795
49Sulfur metabolism_Homo sapiens_hsa009200.92667950
50Systemic lupus erythematosus_Homo sapiens_hsa053220.91521138
51Measles_Homo sapiens_hsa051620.90893154
52Tyrosine metabolism_Homo sapiens_hsa003500.90404642
53Fatty acid metabolism_Homo sapiens_hsa012120.87329982
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87132546
55Leishmaniasis_Homo sapiens_hsa051400.85484614
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84666663
57Viral carcinogenesis_Homo sapiens_hsa052030.84503770
58Other glycan degradation_Homo sapiens_hsa005110.83356992
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82481901
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.80697915
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80483987
62Biosynthesis of amino acids_Homo sapiens_hsa012300.78661033
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77210217
64beta-Alanine metabolism_Homo sapiens_hsa004100.77160752
65Peroxisome_Homo sapiens_hsa041460.77043794
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.76347308
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.74641777
68Sulfur relay system_Homo sapiens_hsa041220.72922488
69Butanoate metabolism_Homo sapiens_hsa006500.72619510
70HTLV-I infection_Homo sapiens_hsa051660.72244394
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.71852693
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71388270
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70176676
74Fatty acid degradation_Homo sapiens_hsa000710.70172319
75Hematopoietic cell lineage_Homo sapiens_hsa046400.69660240
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69010044
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.64538454
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.63717701
79Hepatitis B_Homo sapiens_hsa051610.62728530
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61829405
81Glutathione metabolism_Homo sapiens_hsa004800.61689553
82Shigellosis_Homo sapiens_hsa051310.59991786
83Chemical carcinogenesis_Homo sapiens_hsa052040.59867797
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59769291
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59318020
86Renin-angiotensin system_Homo sapiens_hsa046140.57241615
87Apoptosis_Homo sapiens_hsa042100.56622440
88Carbon metabolism_Homo sapiens_hsa012000.55722044
89Tryptophan metabolism_Homo sapiens_hsa003800.55558140
90Small cell lung cancer_Homo sapiens_hsa052220.55377391
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53018718
92Oocyte meiosis_Homo sapiens_hsa041140.52839938
93Influenza A_Homo sapiens_hsa051640.52459782
94Thyroid cancer_Homo sapiens_hsa052160.49312072
95Arginine and proline metabolism_Homo sapiens_hsa003300.49169938
96Allograft rejection_Homo sapiens_hsa053300.48749855
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48369577
98Viral myocarditis_Homo sapiens_hsa054160.46767919
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44798223
100Nitrogen metabolism_Homo sapiens_hsa009100.44366049
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.44277543
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43595366
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43579120
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42829552
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42611933
106B cell receptor signaling pathway_Homo sapiens_hsa046620.42557998
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41836395
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40597451
109Pertussis_Homo sapiens_hsa051330.40391407
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38681862
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38000583
112Asthma_Homo sapiens_hsa053100.37953875
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37364229
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36059505
115Phenylalanine metabolism_Homo sapiens_hsa003600.35556390
116Retinol metabolism_Homo sapiens_hsa008300.35172580
117Lysine degradation_Homo sapiens_hsa003100.34754037
118Vitamin digestion and absorption_Homo sapiens_hsa049770.34253122
119Galactose metabolism_Homo sapiens_hsa000520.33198978
120Chronic myeloid leukemia_Homo sapiens_hsa052200.31742751
121MicroRNAs in cancer_Homo sapiens_hsa052060.31557658
122Caffeine metabolism_Homo sapiens_hsa002320.30647563
123Vitamin B6 metabolism_Homo sapiens_hsa007500.30464526
124Acute myeloid leukemia_Homo sapiens_hsa052210.29546437
125Malaria_Homo sapiens_hsa051440.28819877
126Osteoclast differentiation_Homo sapiens_hsa043800.28777733
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.27717570
128Collecting duct acid secretion_Homo sapiens_hsa049660.27349983
129Toxoplasmosis_Homo sapiens_hsa051450.25678372
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.24472680
131TGF-beta signaling pathway_Homo sapiens_hsa043500.24318195
132Sphingolipid metabolism_Homo sapiens_hsa006000.23397356
133Staphylococcus aureus infection_Homo sapiens_hsa051500.22513289
134* Metabolic pathways_Homo sapiens_hsa011000.22500472
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22317957
136Fructose and mannose metabolism_Homo sapiens_hsa000510.21623540
137Cardiac muscle contraction_Homo sapiens_hsa042600.21429539
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20873798
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20377038
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20123099
141Tuberculosis_Homo sapiens_hsa051520.19429054
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19091296
143Colorectal cancer_Homo sapiens_hsa052100.19017981
144Histidine metabolism_Homo sapiens_hsa003400.17221675
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17012440
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.16933790
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16090782
148Fat digestion and absorption_Homo sapiens_hsa049750.14829453

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