ALK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coronary vasculature morphogenesis (GO:0060977)9.66076578
2positive regulation of transcription regulatory region DNA binding (GO:2000679)8.87426146
3peripheral nervous system neuron development (GO:0048935)8.75597678
4cell migration involved in heart development (GO:0060973)8.46005714
5regulation of secondary heart field cardioblast proliferation (GO:0003266)8.34291770
6regulation of cardioblast proliferation (GO:0003264)8.34291770
7ganglion development (GO:0061548)8.04302610
8negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.99491183
9cardiac ventricle formation (GO:0003211)7.14633559
10tongue development (GO:0043586)6.86801034
11cartilage morphogenesis (GO:0060536)6.75246662
12cardiac chamber formation (GO:0003207)6.61396075
13spinal cord motor neuron differentiation (GO:0021522)6.34252201
14regulation of short-term neuronal synaptic plasticity (GO:0048172)6.23374782
15locomotory exploration behavior (GO:0035641)6.22152990
16negative regulation of striated muscle cell apoptotic process (GO:0010664)6.14595725
17synaptic vesicle maturation (GO:0016188)5.96314360
18regulation of cell maturation (GO:1903429)5.95797664
19negative regulation of dendrite morphogenesis (GO:0050774)5.87787330
20vocalization behavior (GO:0071625)5.58126045
21regulation of heart morphogenesis (GO:2000826)5.35171983
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34997691
23neuron cell-cell adhesion (GO:0007158)5.33957543
24proline transport (GO:0015824)5.30847019
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30675163
26behavioral response to nicotine (GO:0035095)5.23758505
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03630219
28body morphogenesis (GO:0010171)5.00925731
29mesenchymal cell proliferation (GO:0010463)4.99855293
30positive regulation of cell size (GO:0045793)4.96770667
31regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.94001917
32gamma-aminobutyric acid transport (GO:0015812)4.93709157
33synaptic vesicle exocytosis (GO:0016079)4.87833557
34regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.87828422
35neural crest cell migration (GO:0001755)4.86387368
36protein localization to synapse (GO:0035418)4.82434366
37regulation of cardiac muscle cell apoptotic process (GO:0010665)4.81582518
38regulation of glutamate receptor signaling pathway (GO:1900449)4.81413574
39positive regulation of cell cycle G2/M phase transition (GO:1902751)4.74892860
40positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.74892860
41exploration behavior (GO:0035640)4.65042185
42axon extension involved in axon guidance (GO:0048846)4.60892486
43neuron projection extension involved in neuron projection guidance (GO:1902284)4.60892486
44neurotransmitter secretion (GO:0007269)4.58511651
45positive regulation of glomerulus development (GO:0090193)4.58426089
46regulation of synaptic vesicle exocytosis (GO:2000300)4.55559767
47negative regulation of cell cycle arrest (GO:0071157)4.55262319
48apoptotic process involved in development (GO:1902742)4.50302598
49glutamate secretion (GO:0014047)4.46864649
50layer formation in cerebral cortex (GO:0021819)4.45386253
51regulation of striated muscle cell apoptotic process (GO:0010662)4.42839503
52ionotropic glutamate receptor signaling pathway (GO:0035235)4.39855749
53regulation of glucocorticoid metabolic process (GO:0031943)4.28703154
54response to parathyroid hormone (GO:0071107)4.25157751
55midbrain development (GO:0030901)4.21578683
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18735546
57adult heart development (GO:0007512)4.17342234
58regulation of chemokine-mediated signaling pathway (GO:0070099)4.12600079
59regulation of neuronal synaptic plasticity (GO:0048168)4.08463020
60ectodermal placode formation (GO:0060788)4.06955346
61prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.06547435
62apoptotic process involved in morphogenesis (GO:0060561)4.06304997
63regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06199694
64endocardial cushion morphogenesis (GO:0003203)4.04825200
65glycine transport (GO:0015816)4.03309431
66synaptic vesicle docking involved in exocytosis (GO:0016081)4.02465591
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.94029306
68regulation of synaptic vesicle transport (GO:1902803)3.92988222
69neurotransmitter-gated ion channel clustering (GO:0072578)3.87165742
70neuromuscular process controlling balance (GO:0050885)3.86312241
71cell differentiation in spinal cord (GO:0021515)3.84456115
72glutamate receptor signaling pathway (GO:0007215)3.83902645
73synaptic transmission, glutamatergic (GO:0035249)3.81780925
74dendritic spine morphogenesis (GO:0060997)3.80658803
75embryonic digit morphogenesis (GO:0042733)3.78942520
76neurotransmitter transport (GO:0006836)3.78003545
77long-term memory (GO:0007616)3.72740421
78mesenchyme morphogenesis (GO:0072132)3.72227585
79cell migration in hindbrain (GO:0021535)3.70710395
80regulation of synapse structural plasticity (GO:0051823)3.67865982
81neuron recognition (GO:0008038)3.66938545
82neural crest cell development (GO:0014032)3.64679775
83positive regulation of potassium ion transmembrane transport (GO:1901381)3.62711669
84neuron-neuron synaptic transmission (GO:0007270)3.59759774
85alanine transport (GO:0032328)3.57370001
86adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.54750390
87regulation of neurotransmitter levels (GO:0001505)3.53463516
88regulation of glomerulus development (GO:0090192)3.51638509
89transmission of nerve impulse (GO:0019226)3.51631491
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.51200872
91positive regulation of membrane potential (GO:0045838)3.50151048
92sodium ion export (GO:0071436)3.46268356
93prepulse inhibition (GO:0060134)3.46078751
94postsynaptic membrane organization (GO:0001941)3.43884591
95neuronal action potential propagation (GO:0019227)3.42815046
96auditory behavior (GO:0031223)3.41092838
97cellular response to prostaglandin stimulus (GO:0071379)3.39666097
98cellular potassium ion homeostasis (GO:0030007)3.39415809
99regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38392844
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36502023
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36179499
102retinoic acid metabolic process (GO:0042573)3.35545408
103regulation of glucocorticoid secretion (GO:2000849)3.34692130
104response to auditory stimulus (GO:0010996)3.33110483
105neuronal ion channel clustering (GO:0045161)3.31071964
106regulation of organ formation (GO:0003156)3.28950551
107positive regulation of hair cycle (GO:0042635)3.27182553
108positive regulation of hair follicle development (GO:0051798)3.27182553
109mesenchymal cell development (GO:0014031)3.26819020
110positive regulation of synapse maturation (GO:0090129)3.25857966
111neuromuscular process controlling posture (GO:0050884)3.25361862
112activation of protein kinase A activity (GO:0034199)3.24107670
113post-embryonic morphogenesis (GO:0009886)3.23882799
114regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22970821
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22704933
116mating behavior (GO:0007617)3.22462693
117axonal fasciculation (GO:0007413)3.20773962
118regulation of postsynaptic membrane potential (GO:0060078)3.20463580
119regulation of transcription regulatory region DNA binding (GO:2000677)3.15924004
120synaptic vesicle endocytosis (GO:0048488)3.14890114
121gamma-aminobutyric acid signaling pathway (GO:0007214)3.14645585
122cerebellar Purkinje cell differentiation (GO:0021702)3.14320511
123dendrite morphogenesis (GO:0048813)3.13030062
124regulation of synaptic plasticity (GO:0048167)3.11984536
125cell communication by electrical coupling (GO:0010644)3.11329225
126innervation (GO:0060384)3.09704719
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09670265
128neuromuscular process (GO:0050905)3.08502541
129regulation of synaptic transmission, glutamatergic (GO:0051966)3.07149413
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06758627
131negative regulation of dendrite development (GO:2000171)3.06736805
132negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06396572
133ear development (GO:0043583)3.05459510
134suckling behavior (GO:0001967)3.04183130
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03628773
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01575927
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01339745
138regulation of synaptic transmission, GABAergic (GO:0032228)3.00809674
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00070126
140learning (GO:0007612)2.99658146
141regulation of dendritic spine morphogenesis (GO:0061001)2.97348733
142vesicle transport along microtubule (GO:0047496)2.96413910
143negative regulation of muscle cell apoptotic process (GO:0010656)2.96254169
144embryonic forelimb morphogenesis (GO:0035115)2.95070731
145regulation of respiratory system process (GO:0044065)2.94133089
146regulation of vesicle fusion (GO:0031338)2.93358094
147paraxial mesoderm development (GO:0048339)2.92505729
148long-term synaptic potentiation (GO:0060291)2.92480259
149regulation of neurotransmitter secretion (GO:0046928)2.91413135
150regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90886625
151neuron maturation (GO:0042551)2.88346530
152regulation of hair follicle development (GO:0051797)2.88336240
153membrane depolarization during action potential (GO:0086010)2.87730583
154presynaptic membrane assembly (GO:0097105)2.85305058
155regulation of respiratory gaseous exchange (GO:0043576)2.85295342
156cerebellar Purkinje cell layer development (GO:0021680)2.84512443
157membrane depolarization (GO:0051899)2.84410199
158social behavior (GO:0035176)2.84380048
159intraspecies interaction between organisms (GO:0051703)2.84380048
160heart morphogenesis (GO:0003007)2.84061077
161regulation of neurotransmitter transport (GO:0051588)2.81965145
162membrane hyperpolarization (GO:0060081)2.81882166
163norepinephrine metabolic process (GO:0042415)2.81088709
164negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80998170
165positive regulation of dendritic spine development (GO:0060999)2.80934190
166synapse assembly (GO:0007416)2.79632543
167negative regulation of multicellular organism growth (GO:0040015)2.79384509
168positive regulation of RNA splicing (GO:0033120)2.78374494
169embryonic body morphogenesis (GO:0010172)2.78155314
170glycolytic process (GO:0006096)2.77761000
171proximal/distal pattern formation (GO:0009954)2.77487881
172synaptic transmission (GO:0007268)2.76510635
173organelle transport along microtubule (GO:0072384)2.75706018
174axon cargo transport (GO:0008088)2.74849683
175membrane repolarization during action potential (GO:0086011)2.74706357
176positive regulation of DNA binding (GO:0043388)2.73240857
177cell differentiation in hindbrain (GO:0021533)2.67580791
178forelimb morphogenesis (GO:0035136)2.67514077
179stem cell development (GO:0048864)2.66571976
180negative regulation of astrocyte differentiation (GO:0048712)2.65406288
181neuromuscular synaptic transmission (GO:0007274)2.64740297
182central nervous system neuron differentiation (GO:0021953)2.63434933
183regulation of corticosteroid hormone secretion (GO:2000846)2.61275046
184phenol-containing compound catabolic process (GO:0019336)2.61155787
185positive regulation of steroid hormone secretion (GO:2000833)2.56938860
186diaphragm development (GO:0060539)2.56427718
187central nervous system neuron axonogenesis (GO:0021955)2.55839757
188positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55453149
189eyelid development in camera-type eye (GO:0061029)2.52451051
190sympathetic nervous system development (GO:0048485)16.3312491
191enteric nervous system development (GO:0048484)14.4764180
192dopaminergic neuron differentiation (GO:0071542)13.4366191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80890559
2E2F7_22180533_ChIP-Seq_HELA_Human4.13052440
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.51036073
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18113998
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11886583
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02702470
7GBX2_23144817_ChIP-Seq_PC3_Human2.96469342
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88813470
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88813470
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.84424833
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81741595
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.72427292
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69403310
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62871909
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61713914
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56480802
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56314575
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51867162
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50345472
20* DROSHA_22980978_ChIP-Seq_HELA_Human2.42044924
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41550979
22* TCF4_18268006_ChIP-ChIP_LS174T_Human2.38026555
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.36892061
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.36786500
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35573860
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35325306
27CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.32915070
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.31396641
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29489441
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.27159987
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.25939498
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17421177
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.14904968
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00715491
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99495472
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98997393
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95069889
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92025696
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.87135366
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83627278
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80172073
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72461010
43AR_21572438_ChIP-Seq_LNCaP_Human1.61131794
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.58886309
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.57437285
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56572750
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56463899
48MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.54247533
49STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.53948240
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51024162
51* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50772168
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50173856
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47346240
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.44286396
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.42841461
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39810020
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39275007
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.37985163
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37779818
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36564020
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35677341
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35298889
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.34538240
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.33209811
65KDM2B_26808549_Chip-Seq_K562_Human1.32614237
66* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32304451
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29778134
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28943982
69IGF1R_20145208_ChIP-Seq_DFB_Human1.27668361
70XRN2_22483619_ChIP-Seq_HELA_Human1.26467259
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25277164
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24001305
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23226037
74* LXR_22292898_ChIP-Seq_THP-1_Human1.22787822
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22602582
76MYC_22102868_ChIP-Seq_BL_Human1.22537837
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22076535
78KDM2B_26808549_Chip-Seq_DND41_Human1.21948166
79* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21405255
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.21202062
81* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21016693
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20882208
83TCF7_22412390_ChIP-Seq_EML_Mouse1.19887981
84ZNF274_21170338_ChIP-Seq_K562_Hela1.19838837
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.19353475
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18815466
87TAF15_26573619_Chip-Seq_HEK293_Human1.18544263
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18297272
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16973890
90AR_19668381_ChIP-Seq_PC3_Human1.16931665
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14768264
92SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14380876
93* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13143167
94* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12522623
95RNF2_27304074_Chip-Seq_NSC_Mouse1.11926366
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11913486
97TTF2_22483619_ChIP-Seq_HELA_Human1.10898628
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10756314
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10298527
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09469323
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08580591
102* STAT3_23295773_ChIP-Seq_U87_Human1.08186167
103RACK7_27058665_Chip-Seq_MCF-7_Human1.08123507
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08069178
105CTCF_27219007_Chip-Seq_Bcells_Human1.07605093
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07126915
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.06085461
108* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05291200
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04906285
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03232197
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02885191
112P300_19829295_ChIP-Seq_ESCs_Human1.02554164
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01054748
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.00930269
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99458481
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99436859
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99083316
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98615980
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.98436585
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98435074
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.98330188
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97997349
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97835111
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96387934
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96012724
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95801788
127* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95518430
128SMC4_20622854_ChIP-Seq_HELA_Human0.95294481
129AR_25329375_ChIP-Seq_VCAP_Human0.95259523
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.94745662
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94593572
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94450180
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94122595
134AHR_22903824_ChIP-Seq_MCF-7_Human0.93622687
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92784940
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91945616
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90690271
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.90045119
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.89927207
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89771512
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.89754025
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89538253
143MYC_18555785_ChIP-Seq_MESCs_Mouse0.89287939
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88689971
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88673552
146* TCF4_23295773_ChIP-Seq_U87_Human0.88504768
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88373470
148* SMAD3_21741376_ChIP-Seq_HESCs_Human0.87156588
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.86584097
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86097302
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85609726
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83732128
153STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82835983
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82713883
155* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82114091
156* RUNX2_22187159_ChIP-Seq_PCA_Human0.81278035
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80099236
158ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78625794
159LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78566251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.50268833
2MP0003567_abnormal_fetal_cardiomyocyte4.69493370
3MP0002009_preneoplasia4.20558085
4MP0003880_abnormal_central_pattern4.12507630
5MP0002163_abnormal_gland_morphology4.00219058
6MP0003635_abnormal_synaptic_transmissio3.84902780
7MP0005423_abnormal_somatic_nervous3.43363246
8MP0009745_abnormal_behavioral_response3.23967706
9MP0009046_muscle_twitch3.22086708
10MP0004858_abnormal_nervous_system3.18856197
11MP0005187_abnormal_penis_morphology3.04355160
12MP0004270_analgesia3.02428495
13MP0002063_abnormal_learning/memory/cond3.01458567
14MP0002064_seizures2.99967753
15MP0009053_abnormal_anal_canal2.83984421
16MP0002572_abnormal_emotion/affect_behav2.64547821
17MP0005645_abnormal_hypothalamus_physiol2.54160466
18MP0001968_abnormal_touch/_nociception2.48901492
19MP0002734_abnormal_mechanical_nocicepti2.48139516
20MP0005379_endocrine/exocrine_gland_phen2.46192251
21MP0001270_distended_abdomen2.45408223
22MP0001501_abnormal_sleep_pattern2.43841563
23MP0002272_abnormal_nervous_system2.33765262
24MP0006138_congestive_heart_failure2.33464911
25MP0001486_abnormal_startle_reflex2.32690985
26MP0002822_catalepsy2.25257666
27MP0000538_abnormal_urinary_bladder2.14098166
28MP0008877_abnormal_DNA_methylation2.05652430
29MP0002184_abnormal_innervation2.05279579
30MP0000778_abnormal_nervous_system2.05206739
31MP0002733_abnormal_thermal_nociception1.95747286
32MP0001970_abnormal_pain_threshold1.92032267
33MP0003942_abnormal_urinary_system1.87393129
34MP0003787_abnormal_imprinting1.85725781
35MP0003868_abnormal_feces_composition1.84855295
36MP0002735_abnormal_chemical_nociception1.82150771
37MP0004811_abnormal_neuron_physiology1.81181061
38MP0002736_abnormal_nociception_after1.75965702
39MP0001440_abnormal_grooming_behavior1.75681855
40MP0003136_yellow_coat_color1.74647119
41MP0003122_maternal_imprinting1.74469859
42MP0002909_abnormal_adrenal_gland1.70619417
43MP0000955_abnormal_spinal_cord1.69965164
44MP0002653_abnormal_ependyma_morphology1.65954825
45MP0002557_abnormal_social/conspecific_i1.65811167
46MP0009780_abnormal_chondrocyte_physiolo1.65358357
47MP0002067_abnormal_sensory_capabilities1.64160106
48MP0008569_lethality_at_weaning1.63127209
49MP0006276_abnormal_autonomic_nervous1.61537056
50MP0000049_abnormal_middle_ear1.59156255
51MP0003937_abnormal_limbs/digits/tail_de1.56107136
52MP0005171_absent_coat_pigmentation1.54321240
53MP0004885_abnormal_endolymph1.48970923
54MP0003329_amyloid_beta_deposits1.47910089
55MP0003115_abnormal_respiratory_system1.47710326
56MP0002882_abnormal_neuron_morphology1.46193378
57MP0004233_abnormal_muscle_weight1.45811506
58MP0001502_abnormal_circadian_rhythm1.44246809
59MP0001529_abnormal_vocalization1.38985996
60MP0005386_behavior/neurological_phenoty1.35149740
61MP0004924_abnormal_behavior1.35149740
62MP0002066_abnormal_motor_capabilities/c1.31118312
63MP0006072_abnormal_retinal_apoptosis1.29828093
64MP0005646_abnormal_pituitary_gland1.29077805
65MP0004142_abnormal_muscle_tone1.27802160
66MP0003283_abnormal_digestive_organ1.24710128
67MP0002932_abnormal_joint_morphology1.24692771
68MP0000647_abnormal_sebaceous_gland1.22232474
69MP0003959_abnormal_lean_body1.21985600
70MP0008961_abnormal_basal_metabolism1.18798404
71MP0002697_abnormal_eye_size1.15841033
72MP0003646_muscle_fatigue1.13299356
73MP0003633_abnormal_nervous_system1.12599086
74MP0010030_abnormal_orbit_morphology1.11411203
75MP0000681_abnormal_thyroid_gland1.09714464
76MP0005499_abnormal_olfactory_system1.08737634
77MP0005394_taste/olfaction_phenotype1.08737634
78MP0001984_abnormal_olfaction1.08495753
79MP0005551_abnormal_eye_electrophysiolog1.08281175
80MP0001188_hyperpigmentation1.08143258
81MP0002229_neurodegeneration1.07984270
82MP0002152_abnormal_brain_morphology1.07939920
83MP0003634_abnormal_glial_cell1.06577419
84MP0005197_abnormal_uvea_morphology1.06099415
85MP0002127_abnormal_cardiovascular_syste1.05669598
86MP0002090_abnormal_vision1.03614975
87MP0000003_abnormal_adipose_tissue1.02036195
88MP0003879_abnormal_hair_cell1.01902810
89MP0003631_nervous_system_phenotype0.99798642
90MP0008872_abnormal_physiological_respon0.97376360
91MP0005167_abnormal_blood-brain_barrier0.97107035
92MP0004742_abnormal_vestibular_system0.96150144
93MP0002752_abnormal_somatic_nervous0.96045180
94MP0002249_abnormal_larynx_morphology0.95999082
95MP0000762_abnormal_tongue_morphology0.95276371
96MP0010307_abnormal_tumor_latency0.94282207
97MP0001664_abnormal_digestion0.94031166
98MP0000427_abnormal_hair_cycle0.93960918
99MP0002069_abnormal_eating/drinking_beha0.93469657
100MP0004043_abnormal_pH_regulation0.92806063
101MP0002166_altered_tumor_susceptibility0.92769483
102MP0002751_abnormal_autonomic_nervous0.92719820
103MP0003045_fibrosis0.90718438
104MP0000569_abnormal_digit_pigmentation0.90685412
105MP0003948_abnormal_gas_homeostasis0.88712584
106MP0000428_abnormal_craniofacial_morphol0.88662232
107MP0003866_abnormal_defecation0.87209087
108MP0003690_abnormal_glial_cell0.87119402
109MP0005503_abnormal_tendon_morphology0.85384780
110MP0000477_abnormal_intestine_morphology0.85382435
111MP0003632_abnormal_nervous_system0.84533828
112MP0002109_abnormal_limb_morphology0.84222167
113MP0005623_abnormal_meninges_morphology0.82904377
114MP0000613_abnormal_salivary_gland0.82066732
115MP0003943_abnormal_hepatobiliary_system0.82031723
116MP0000534_abnormal_ureter_morphology0.81769108
117MP0004085_abnormal_heartbeat0.81195224
118MP0003935_abnormal_craniofacial_develop0.80235593
119MP0000751_myopathy0.79849190
120MP0003075_altered_response_to0.79154507
121MP0001963_abnormal_hearing_physiology0.78871561
122MP0001348_abnormal_lacrimal_gland0.78019783
123MP0008874_decreased_physiological_sensi0.77897988
124MP0002106_abnormal_muscle_physiology0.77802157
125MP0001340_abnormal_eyelid_morphology0.77675672
126MP0003077_abnormal_cell_cycle0.77344687
127MP0001177_atelectasis0.76756224
128MP0002092_abnormal_eye_morphology0.76024960
129MP0000631_abnormal_neuroendocrine_gland0.75450649
130MP0001905_abnormal_dopamine_level0.75297821
131MP0002085_abnormal_embryonic_tissue0.74699378
132MP0005253_abnormal_eye_physiology0.74652529
133MP0004145_abnormal_muscle_electrophysio0.73137838
134MP0002638_abnormal_pupillary_reflex0.73108246
135MP0009250_abnormal_appendicular_skeleto0.72646276
136MP0003123_paternal_imprinting0.68956627
137MP0000920_abnormal_myelination0.68632194
138MP0003121_genomic_imprinting0.68387470
139MP0000759_abnormal_skeletal_muscle0.68225411
140MP0008770_decreased_survivor_rate0.67835512
141MP0008932_abnormal_embryonic_tissue0.67232438
142MP0005391_vision/eye_phenotype0.66649678
143MP0001943_abnormal_respiration0.64881238
144MP0003861_abnormal_nervous_system0.64525263
145MP0003137_abnormal_impulse_conducting0.64277515
146MP0010630_abnormal_cardiac_muscle0.63566864
147MP0002084_abnormal_developmental_patter0.61722959
148MP0005369_muscle_phenotype0.61098673
149MP0005535_abnormal_body_temperature0.60627233
150MP0001346_abnormal_lacrimal_gland0.60043003
151MP0004484_altered_response_of0.58947049
152MP0005380_embryogenesis_phenotype0.58897692
153MP0001672_abnormal_embryogenesis/_devel0.58897692
154MP0010386_abnormal_urinary_bladder0.58881157
155MP0005385_cardiovascular_system_phenoty0.57794063
156MP0001544_abnormal_cardiovascular_syste0.57794063
157MP0010770_preweaning_lethality0.56899070
158MP0002082_postnatal_lethality0.56899070
159MP0001730_embryonic_growth_arrest0.54790294
160MP0002160_abnormal_reproductive_system0.53214198
161MP0010769_abnormal_survival0.53087754
162MP0002116_abnormal_craniofacial_bone0.52359975
163MP0001731_abnormal_postnatal_growth0.51082795
164MP0010768_mortality/aging0.50342869
165MP0003984_embryonic_growth_retardation0.50296872

Predicted human phenotypes

RankGene SetZ-score
1Exotropia (HP:0000577)6.73049648
2Esophageal atresia (HP:0002032)6.52337601
3Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)6.50676544
4Focal motor seizures (HP:0011153)6.19904898
5Myokymia (HP:0002411)5.90379839
6Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)5.88995240
7Abnormality of the middle phalanx of the 5th finger (HP:0004219)5.35022270
8Focal seizures (HP:0007359)5.02161443
9Abnormality of the phalanges of the 2nd finger (HP:0009541)4.95582115
10Abnormality of the phalanges of the 5th finger (HP:0004213)4.90413601
11Short middle phalanx of the 5th finger (HP:0004220)4.84179792
12Visual hallucinations (HP:0002367)4.65835602
13Depressed nasal tip (HP:0000437)4.56111764
14Hyperparathyroidism (HP:0000843)4.48616021
15Intestinal atresia (HP:0011100)4.47331795
16Atonic seizures (HP:0010819)4.45205500
17External ophthalmoplegia (HP:0000544)4.37236919
18Epileptic encephalopathy (HP:0200134)4.02640574
19Febrile seizures (HP:0002373)3.93490005
20Abnormality of the parathyroid morphology (HP:0011766)3.81699028
21Abnormality of the 4th metacarpal (HP:0010012)3.80210128
22Absence seizures (HP:0002121)3.77718940
23Progressive cerebellar ataxia (HP:0002073)3.77168771
24Gastrointestinal atresia (HP:0002589)3.76614425
25Neuroblastic tumors (HP:0004376)3.73914993
26Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.73914993
27Neuroblastoma (HP:0003006)3.73914993
28Primitive neuroectodermal tumor (HP:0030065)3.73914993
29Renal dysplasia (HP:0000110)3.73234096
30Supranuclear gaze palsy (HP:0000605)3.73034386
31Generalized tonic-clonic seizures (HP:0002069)3.71082982
32Abnormality of the phalanges of the hallux (HP:0010057)3.65923481
33Bicornuate uterus (HP:0000813)3.65915768
34Action tremor (HP:0002345)3.57523141
35Enlarged penis (HP:0000040)3.50704374
36Aplasia/Hypoplasia of the spleen (HP:0010451)3.49219499
37Supernumerary spleens (HP:0009799)3.47510488
38Dialeptic seizures (HP:0011146)3.31922316
39Ankle clonus (HP:0011448)3.31513550
40Broad distal phalanx of finger (HP:0009836)3.26128413
41Abnormality of the distal phalanges of the toes (HP:0010182)3.21863621
42Abnormal umbilical cord blood vessels (HP:0011403)3.21290426
43Single umbilical artery (HP:0001195)3.21290426
44Abnormality of the fetal cardiovascular system (HP:0010948)3.21290426
45Mutism (HP:0002300)3.18620339
46Abnormality of the 2nd finger (HP:0004100)3.18533832
47Pheochromocytoma (HP:0002666)3.02562806
48Occipital encephalocele (HP:0002085)3.00763677
49Impaired vibration sensation in the lower limbs (HP:0002166)3.00702880
50Hyperthyroidism (HP:0000836)3.00694572
51Depression (HP:0000716)2.99680678
52Menstrual irregularities (HP:0000858)2.97632956
53Impaired social interactions (HP:0000735)2.96566685
54Abnormal social behavior (HP:0012433)2.96566685
55Hypothermia (HP:0002045)2.96238412
56Ectopic kidney (HP:0000086)2.93214176
57Hyperventilation (HP:0002883)2.90025570
58Dysdiadochokinesis (HP:0002075)2.88605539
59Poor eye contact (HP:0000817)2.87962128
60Neuroectodermal neoplasm (HP:0030061)2.85631145
61Neuroepithelial neoplasm (HP:0030063)2.85631145
62Nervous tissue neoplasm (HP:0030060)2.85631145
63Abnormality of the corticospinal tract (HP:0002492)2.81767269
64Amblyopia (HP:0000646)2.73918188
65Abnormality of the vocal cords (HP:0008777)2.72347368
66Urinary bladder sphincter dysfunction (HP:0002839)2.70089851
67Hypercortisolism (HP:0001578)2.69401800
68Drooling (HP:0002307)2.68398186
69Excessive salivation (HP:0003781)2.68398186
70Postural instability (HP:0002172)2.67825394
71Abnormality of the lower motor neuron (HP:0002366)2.67183725
72Truncal ataxia (HP:0002078)2.64849223
73Broad-based gait (HP:0002136)2.62855081
74Abnormality of the aortic arch (HP:0012303)2.62710463
75Hemiparesis (HP:0001269)2.60688306
76Neurofibrillary tangles (HP:0002185)2.60215575
77Anxiety (HP:0000739)2.58346075
78Dysmetria (HP:0001310)2.58121132
79Malignant neoplasm of the central nervous system (HP:0100836)2.57499724
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.56025722
81Cerebral inclusion bodies (HP:0100314)2.52811756
82Asplenia (HP:0001746)2.51751279
83Asymmetry of the thorax (HP:0001555)2.50814458
84Cutaneous finger syndactyly (HP:0010554)2.50600509
85Genetic anticipation (HP:0003743)2.50396273
86Neuroendocrine neoplasm (HP:0100634)2.46311229
87Blue irides (HP:0000635)2.45436542
88Agitation (HP:0000713)2.44559555
89Adrenal overactivity (HP:0002717)2.44312306
90Aplasia involving bones of the upper limbs (HP:0009823)2.44109820
91Aplasia of the phalanges of the hand (HP:0009802)2.44109820
92Aplasia involving bones of the extremities (HP:0009825)2.44109820
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41150889
94Papilledema (HP:0001085)2.41043647
95Abnormal eating behavior (HP:0100738)2.39847679
96Failure to thrive in infancy (HP:0001531)2.38105175
97Hemiplegia (HP:0002301)2.35283972
98Status epilepticus (HP:0002133)2.34073499
99Short palpebral fissure (HP:0012745)2.33556376
100Megalencephaly (HP:0001355)2.33347073
101Spastic gait (HP:0002064)2.32846067
102Narrow nasal bridge (HP:0000446)2.28640223
103Progressive inability to walk (HP:0002505)2.27636892
104Ankyloglossia (HP:0010296)2.27331438
105Cutaneous syndactyly (HP:0012725)2.25387287
106Short 5th finger (HP:0009237)2.24902291
107Ventricular fibrillation (HP:0001663)2.24630268
108Hypoventilation (HP:0002791)2.22565291
109Orthostatic hypotension (HP:0001278)2.22089659
110Neuronal loss in central nervous system (HP:0002529)2.21221159
111Growth hormone excess (HP:0000845)2.20775136
112Amyotrophic lateral sclerosis (HP:0007354)2.20535500
113Abnormality of the intervertebral disk (HP:0005108)2.19998764
114Abnormality of the umbilical cord (HP:0010881)2.19251762
115Non-midline cleft lip (HP:0100335)2.17880564
116Generalized myoclonic seizures (HP:0002123)2.15954178
117Bell-shaped thorax (HP:0001591)2.15931151
118Intention tremor (HP:0002080)2.15501822
119Macroorchidism (HP:0000053)2.13458428
120Torticollis (HP:0000473)2.12947651
121Gaze-evoked nystagmus (HP:0000640)2.12606696
122Potter facies (HP:0002009)2.12331144
123Facial shape deformation (HP:0011334)2.12331144
124Bowel diverticulosis (HP:0005222)2.08463154
125Long palpebral fissure (HP:0000637)2.07410433
126Bradykinesia (HP:0002067)2.07172980
127Bilateral microphthalmos (HP:0007633)2.05935589
128Vaginal atresia (HP:0000148)2.05618568
129Urinary urgency (HP:0000012)2.05576885
130Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.03376058
131Lower limb amyotrophy (HP:0007210)2.03055625
132Genital tract atresia (HP:0001827)2.02577592
133Trigonocephaly (HP:0000243)2.01930803
134Termporal pattern (HP:0011008)2.01159888
135Insidious onset (HP:0003587)2.01159888
136Disproportionate tall stature (HP:0001519)2.01153207
137Insomnia (HP:0100785)2.01141875
138Testicular neoplasm (HP:0010788)2.01135054
139Fetal akinesia sequence (HP:0001989)1.99913893
140Aqueductal stenosis (HP:0002410)1.99892902
141Abnormal sex determination (HP:0012244)1.99083581
142Sex reversal (HP:0012245)1.99083581
143Impaired vibratory sensation (HP:0002495)1.99070340
144Abnormality of binocular vision (HP:0011514)1.98690798
145Diplopia (HP:0000651)1.98690798
146Thyroid carcinoma (HP:0002890)1.96741884
147Goiter (HP:0000853)1.95311665
148Lower limb muscle weakness (HP:0007340)1.94659071
149Epileptiform EEG discharges (HP:0011182)1.94564225
150Absent radius (HP:0003974)1.94328483
151Neonatal hypoglycemia (HP:0001998)1.94164581
152EEG with generalized epileptiform discharges (HP:0011198)1.93471600
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92680226
154Short 4th metacarpal (HP:0010044)1.92680226
155Abnormality of the middle phalanges of the toes (HP:0010183)1.92571587
156Clonus (HP:0002169)1.91666836
157Renal agenesis (HP:0000104)1.90119345
158Aplastic anemia (HP:0001915)1.89956384
159Polyphagia (HP:0002591)1.89181590
160Stereotypic behavior (HP:0000733)1.88159871
161Hypsarrhythmia (HP:0002521)1.87513514
162Resting tremor (HP:0002322)1.87237807
163Impaired smooth pursuit (HP:0007772)1.86649893
164Short metatarsal (HP:0010743)1.86047903
165Focal dystonia (HP:0004373)1.85897436
166Gait imbalance (HP:0002141)1.83265233
167Neoplasm of the peripheral nervous system (HP:0100007)1.82820574
168Akinesia (HP:0002304)1.82292980
169Abnormality of ocular smooth pursuit (HP:0000617)1.81852922
170Pointed chin (HP:0000307)1.81402193
171Absent forearm bone (HP:0003953)1.81041224
172Aplasia involving forearm bones (HP:0009822)1.81041224
173Intestinal polyposis (HP:0200008)1.80948195
174Abnormality of calcium-phosphate metabolism (HP:0100530)1.80603966
175Midline defect of the nose (HP:0004122)1.80572396
176Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.80124058
177Abnormal EKG (HP:0003115)1.79978509
178Abnormality of salivation (HP:0100755)1.79738176
179Annular pancreas (HP:0001734)1.79575963
180Symphalangism affecting the phalanges of the hand (HP:0009773)1.78957576
181Abnormal auditory evoked potentials (HP:0006958)1.78933391
182Hypercalcemia (HP:0003072)1.77563639
183Short clavicles (HP:0000894)1.77022986
184Shawl scrotum (HP:0000049)1.74888673
185Intestinal polyp (HP:0005266)1.71563431
186Cerebral hemorrhage (HP:0001342)1.69658331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT35.25024890
2MAP3K105.12382723
3NTRK34.10172086
4MAP3K94.08924925
5MARK13.69159200
6EPHA43.21179036
7NME23.17717271
8PRKD33.01871366
9MAP3K42.95654716
10NTRK22.82409048
11NTRK12.66019732
12MET2.63192071
13MINK12.45959394
14MAP2K72.36545797
15PLK42.34904002
16PAK62.27671631
17GRK52.00208932
18DAPK21.98640591
19EEF2K1.95288282
20MAP2K41.91136863
21TNIK1.89409720
22CDK81.86240545
23TAF11.74382878
24MOS1.72628294
25LATS21.67493149
26INSRR1.64097559
27CDK61.62891528
28MAPK131.62711230
29DYRK1B1.61301388
30SMG11.60761450
31PKN21.55529044
32UHMK11.49785719
33KSR21.47951439
34CLK11.46848745
35CASK1.46002808
36CAMKK11.45629491
37PHKG21.44389878
38PHKG11.44389878
39NME11.42548813
40CDK51.41832300
41CHEK21.41468607
42TYRO31.41048706
43MAP3K121.32920154
44SIK21.31379036
45ICK1.18022611
46SRPK11.16719143
47AKT21.16073945
48PRKCH1.15771137
49PRKCG1.15338315
50STK381.14106020
51RET1.11831489
52LMTK21.10794283
53MTOR1.09289850
54CSNK1G31.07758849
55CDK71.07464328
56FES1.07225574
57CSNK1G11.06827916
58CSNK1A1L1.05465977
59CDK41.04373311
60DAPK11.04128316
61PLK21.03592429
62MAP3K61.02534613
63PDGFRB1.01571369
64PNCK0.99646788
65KSR10.99214452
66* ALK0.98708837
67RIPK40.97817558
68MAP3K20.96952994
69CAMK10.96583690
70TAOK10.93946921
71SIK30.93621828
72CAMK2A0.93275984
73EIF2AK10.92259827
74ZAP700.91352409
75VRK20.89049259
76BRD40.88798784
77PBK0.88326936
78MARK20.85884950
79TTK0.85204720
80DDR20.80576732
81JAK30.79258012
82WNK10.78439489
83CDK150.78322231
84CDK140.78023190
85CDK180.75874635
86STK110.75799967
87MAPK110.74162298
88CDC42BPA0.72990007
89CAMK40.72963051
90CDK30.71305613
91PAK30.70993344
92SGK2230.70922295
93SGK4940.70922295
94CDK190.69631359
95BRSK10.69125898
96MKNK20.68208682
97CDK11A0.66280116
98MELK0.66084778
99RPS6KA20.64230770
100HIPK20.63074859
101TESK10.62063046
102SGK10.62045218
103MAPK70.61062427
104PRKCZ0.60871480
105MAPKAPK50.60528826
106DYRK1A0.58841626
107ARAF0.58744884
108MAPK100.57413631
109PRKCE0.57125346
110PINK10.57031422
111TRPM70.56783269
112CAMK2B0.56393014
113RPS6KA30.55313712
114CSNK1G20.55290325
115PRPF4B0.55215208
116MAP3K70.54357762
117CAMK1G0.54322850
118PRKD20.51348811
119PDGFRA0.51146928
120CDK90.49967702
121PTK20.48763607
122DYRK20.48218910
123FER0.47462300
124SGK30.46763356
125PKN10.46523841
126AKT30.46521528
127STK40.46374184
128FGR0.45096308
129SGK20.44610776
130YES10.43855387
131BMX0.43543907
132NEK20.43435121
133PDK10.43029291
134SCYL20.43020035
135CAMKK20.42763570
136TSSK60.42520971
137NEK10.42505382
138STK30.41228718
139FGFR20.40479004
140RPS6KL10.40385445
141RPS6KC10.40385445
142CHEK10.40358324
143FYN0.40128191
144MAP3K10.39834785
145GRK10.39805997
146NEK60.39502648
147ADRBK10.39356163
148CAMK2D0.39118387
149RIPK10.38190839
150TNK20.37973613
151CDK20.37904098
152CAMK2G0.37722753
153ROCK10.36551533
154EPHB20.35580007
155MAPK120.35576490
156MKNK10.35183845
157AKT10.35070682
158GSK3B0.34497106
159PIM10.31149072
160PAK20.29291475
161RPS6KA60.28618288
162MAPK140.28552971
163CDK10.26104405
164ATR0.25574236
165OXSR10.24230820
166MAPK10.24221291
167SRC0.22433103
168FGFR10.22089505

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052163.69974034
2Nicotine addiction_Homo sapiens_hsa050333.62737794
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.27097720
4Synaptic vesicle cycle_Homo sapiens_hsa047213.24482743
5GABAergic synapse_Homo sapiens_hsa047272.98352481
6Olfactory transduction_Homo sapiens_hsa047402.59244501
7Circadian entrainment_Homo sapiens_hsa047132.53310536
8Chronic myeloid leukemia_Homo sapiens_hsa052202.45416997
9Morphine addiction_Homo sapiens_hsa050322.43752077
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42875727
11Glutamatergic synapse_Homo sapiens_hsa047242.42136838
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39568821
13Long-term potentiation_Homo sapiens_hsa047202.26472231
14Amphetamine addiction_Homo sapiens_hsa050312.21613182
15Salivary secretion_Homo sapiens_hsa049702.21576116
16Biosynthesis of amino acids_Homo sapiens_hsa012302.19542127
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.15559592
18Insulin secretion_Homo sapiens_hsa049112.02461544
19Dopaminergic synapse_Homo sapiens_hsa047282.00622427
20MicroRNAs in cancer_Homo sapiens_hsa052061.93571213
21Cholinergic synapse_Homo sapiens_hsa047251.79591085
22Gastric acid secretion_Homo sapiens_hsa049711.78950750
23Long-term depression_Homo sapiens_hsa047301.78158547
24Taste transduction_Homo sapiens_hsa047421.78126020
25Cell cycle_Homo sapiens_hsa041101.77564475
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74155398
27Cocaine addiction_Homo sapiens_hsa050301.70617685
28Pancreatic cancer_Homo sapiens_hsa052121.63945405
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63178913
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62288694
31Serotonergic synapse_Homo sapiens_hsa047261.56772689
32Calcium signaling pathway_Homo sapiens_hsa040201.56680671
33Notch signaling pathway_Homo sapiens_hsa043301.54654486
34Sphingolipid metabolism_Homo sapiens_hsa006001.53975778
35Lysine degradation_Homo sapiens_hsa003101.48036510
36Renin secretion_Homo sapiens_hsa049241.47384586
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43374362
38Oxytocin signaling pathway_Homo sapiens_hsa049211.41211734
39GnRH signaling pathway_Homo sapiens_hsa049121.39721114
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31262379
41Carbon metabolism_Homo sapiens_hsa012001.30726536
42Gap junction_Homo sapiens_hsa045401.29695380
43HIF-1 signaling pathway_Homo sapiens_hsa040661.28146209
44Spliceosome_Homo sapiens_hsa030401.27595108
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26304382
46Type II diabetes mellitus_Homo sapiens_hsa049301.26265302
47Collecting duct acid secretion_Homo sapiens_hsa049661.25083278
48DNA replication_Homo sapiens_hsa030301.24372835
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22017697
50Axon guidance_Homo sapiens_hsa043601.21793527
51Phototransduction_Homo sapiens_hsa047441.21572623
52cAMP signaling pathway_Homo sapiens_hsa040241.21044647
53Bladder cancer_Homo sapiens_hsa052191.18728615
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15891277
55Melanogenesis_Homo sapiens_hsa049161.13256440
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11864663
57Estrogen signaling pathway_Homo sapiens_hsa049151.11690090
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09196751
59Melanoma_Homo sapiens_hsa052181.08692456
60Fructose and mannose metabolism_Homo sapiens_hsa000511.07500172
61mRNA surveillance pathway_Homo sapiens_hsa030151.06155259
62Small cell lung cancer_Homo sapiens_hsa052221.05625700
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03106327
64Base excision repair_Homo sapiens_hsa034101.01952581
65ErbB signaling pathway_Homo sapiens_hsa040121.01005373
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00811575
67Prostate cancer_Homo sapiens_hsa052151.00724611
68Glioma_Homo sapiens_hsa052140.97572462
69Cardiac muscle contraction_Homo sapiens_hsa042600.95254734
70Prolactin signaling pathway_Homo sapiens_hsa049170.95205649
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93453937
72Dorso-ventral axis formation_Homo sapiens_hsa043200.90891257
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.90282733
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89906665
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.89215929
76Nitrogen metabolism_Homo sapiens_hsa009100.87935651
77Vibrio cholerae infection_Homo sapiens_hsa051100.87154134
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87151720
79Pathways in cancer_Homo sapiens_hsa052000.83222443
80Dilated cardiomyopathy_Homo sapiens_hsa054140.82911450
81Type I diabetes mellitus_Homo sapiens_hsa049400.81554896
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79501102
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78793005
84Oocyte meiosis_Homo sapiens_hsa041140.77145523
85AMPK signaling pathway_Homo sapiens_hsa041520.73671218
86Thyroid hormone synthesis_Homo sapiens_hsa049180.72446033
87Pancreatic secretion_Homo sapiens_hsa049720.72177002
88Bile secretion_Homo sapiens_hsa049760.71575087
89MAPK signaling pathway_Homo sapiens_hsa040100.70624731
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70068542
91Arginine biosynthesis_Homo sapiens_hsa002200.69808518
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69328332
93mTOR signaling pathway_Homo sapiens_hsa041500.69190703
94Choline metabolism in cancer_Homo sapiens_hsa052310.69141446
95Pentose phosphate pathway_Homo sapiens_hsa000300.68837329
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67885419
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.64424199
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63917496
99Tyrosine metabolism_Homo sapiens_hsa003500.63580456
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63111441
101Vitamin B6 metabolism_Homo sapiens_hsa007500.62826736
102Phenylalanine metabolism_Homo sapiens_hsa003600.61183344
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60972619
104Rap1 signaling pathway_Homo sapiens_hsa040150.60499235
105Glucagon signaling pathway_Homo sapiens_hsa049220.57592883
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57438383
107Basal cell carcinoma_Homo sapiens_hsa052170.57242280
108Ovarian steroidogenesis_Homo sapiens_hsa049130.56880809
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56799371
110Ras signaling pathway_Homo sapiens_hsa040140.55885471
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55600691
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55081095
113Hepatitis B_Homo sapiens_hsa051610.54814334
114Alcoholism_Homo sapiens_hsa050340.52790358
115Endometrial cancer_Homo sapiens_hsa052130.51135902
116Wnt signaling pathway_Homo sapiens_hsa043100.51004771
117RNA transport_Homo sapiens_hsa030130.50983586
118Inositol phosphate metabolism_Homo sapiens_hsa005620.50922464
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.50347045
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49961869
121Mismatch repair_Homo sapiens_hsa034300.46669646
122Endocytosis_Homo sapiens_hsa041440.46639966
123VEGF signaling pathway_Homo sapiens_hsa043700.45633933
124FoxO signaling pathway_Homo sapiens_hsa040680.45322007
125Insulin signaling pathway_Homo sapiens_hsa049100.44900427
126Pyrimidine metabolism_Homo sapiens_hsa002400.44728442
127Fatty acid biosynthesis_Homo sapiens_hsa000610.44477383
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43455244
129Viral myocarditis_Homo sapiens_hsa054160.42367353
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41005291
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40688827
132Hedgehog signaling pathway_Homo sapiens_hsa043400.40015578
133Butanoate metabolism_Homo sapiens_hsa006500.39131404
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.38314431
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36070375
136Renal cell carcinoma_Homo sapiens_hsa052110.35671019
137Circadian rhythm_Homo sapiens_hsa047100.35539489
138Prion diseases_Homo sapiens_hsa050200.34312220
139Hippo signaling pathway_Homo sapiens_hsa043900.33697984
140* Non-small cell lung cancer_Homo sapiens_hsa052230.29715460
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29478348
142Colorectal cancer_Homo sapiens_hsa052100.28293670

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