ALKBH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.51340939
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.99529369
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.99529369
4positive regulation of mitotic sister chromatid separation (GO:1901970)4.99529369
5DNA deamination (GO:0045006)4.87409533
6regulation of meiosis I (GO:0060631)4.63668939
7positive regulation of chromosome segregation (GO:0051984)4.37281791
8protein prenylation (GO:0018342)4.33487887
9prenylation (GO:0097354)4.33487887
10double-strand break repair via nonhomologous end joining (GO:0006303)4.30572300
11non-recombinational repair (GO:0000726)4.30572300
12synapsis (GO:0007129)4.27947964
13maturation of SSU-rRNA (GO:0030490)4.15621665
14regulation of sister chromatid cohesion (GO:0007063)4.13725981
15telomere maintenance via semi-conservative replication (GO:0032201)3.89749298
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88353891
17DNA replication initiation (GO:0006270)3.87749618
18DNA strand elongation involved in DNA replication (GO:0006271)3.84738074
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76116122
20DNA strand elongation (GO:0022616)3.74761603
21kinetochore organization (GO:0051383)3.71078261
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70089191
23IMP biosynthetic process (GO:0006188)3.64879586
24establishment of integrated proviral latency (GO:0075713)3.64159543
25mitochondrial RNA metabolic process (GO:0000959)3.62518248
26telomere maintenance via recombination (GO:0000722)3.60662947
27DNA unwinding involved in DNA replication (GO:0006268)3.60106377
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.59778127
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58121711
30cullin deneddylation (GO:0010388)3.51941580
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51628080
32negative regulation of ligase activity (GO:0051352)3.51628080
33viral transcription (GO:0019083)3.51004203
34kinetochore assembly (GO:0051382)3.50118666
35CENP-A containing nucleosome assembly (GO:0034080)3.48930690
36mitotic recombination (GO:0006312)3.48726158
37protein deneddylation (GO:0000338)3.45333920
38translational termination (GO:0006415)3.45110377
39chromatin remodeling at centromere (GO:0031055)3.40300182
40pteridine-containing compound biosynthetic process (GO:0042559)3.37344841
41ribosome biogenesis (GO:0042254)3.33801075
42piRNA metabolic process (GO:0034587)3.33547523
43ribonucleoprotein complex biogenesis (GO:0022613)3.33363661
44transcription-coupled nucleotide-excision repair (GO:0006283)3.31423510
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30074822
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30074822
47DNA replication checkpoint (GO:0000076)3.29738737
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.29625795
49ribosomal small subunit biogenesis (GO:0042274)3.29527508
50ribosomal large subunit biogenesis (GO:0042273)3.29109827
51DNA damage response, detection of DNA damage (GO:0042769)3.26191926
52pseudouridine synthesis (GO:0001522)3.25981981
53telomere maintenance via telomere lengthening (GO:0010833)3.23943952
54regulation of mitotic sister chromatid separation (GO:0010965)3.23224349
55regulation of mitotic sister chromatid segregation (GO:0033047)3.23224349
56regulation of sister chromatid segregation (GO:0033045)3.23224349
57regulation of cellular amino acid metabolic process (GO:0006521)3.17484921
58mitotic metaphase plate congression (GO:0007080)3.16834781
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14950765
60rRNA processing (GO:0006364)3.14757468
61nuclear pore complex assembly (GO:0051292)3.14415867
62DNA replication-independent nucleosome assembly (GO:0006336)3.13935011
63DNA replication-independent nucleosome organization (GO:0034724)3.13935011
64nucleobase biosynthetic process (GO:0046112)3.13865742
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13682696
66metaphase plate congression (GO:0051310)3.11745558
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10908395
68attachment of spindle microtubules to kinetochore (GO:0008608)3.10134672
69protein localization to kinetochore (GO:0034501)3.09474788
70translational elongation (GO:0006414)3.09337691
71spindle checkpoint (GO:0031577)3.09095843
72IMP metabolic process (GO:0046040)3.07969479
73regulation of chromosome segregation (GO:0051983)3.07357776
74nuclear pore organization (GO:0006999)3.07316759
75mitotic spindle checkpoint (GO:0071174)3.07010064
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06877651
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06877651
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06877651
79tRNA methylation (GO:0030488)3.06489743
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05824527
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05824527
827-methylguanosine mRNA capping (GO:0006370)3.05757270
83activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.05479018
84rRNA metabolic process (GO:0016072)3.04992404
85cotranslational protein targeting to membrane (GO:0006613)3.04177760
86DNA catabolic process, exonucleolytic (GO:0000738)3.02875025
87mitotic nuclear envelope disassembly (GO:0007077)3.02654010
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02614674
89protein targeting to ER (GO:0045047)3.01747997
90positive regulation of ligase activity (GO:0051351)3.01245836
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.99501847
92G1/S transition of mitotic cell cycle (GO:0000082)2.98819739
93cell cycle G1/S phase transition (GO:0044843)2.98819739
94telomere maintenance (GO:0000723)2.98302208
95metallo-sulfur cluster assembly (GO:0031163)2.97908044
96iron-sulfur cluster assembly (GO:0016226)2.97908044
97establishment of viral latency (GO:0019043)2.97244516
98RNA capping (GO:0036260)2.96996412
997-methylguanosine RNA capping (GO:0009452)2.96996412
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.96407590
101signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96407590
102respiratory chain complex IV assembly (GO:0008535)2.96371308
103telomere organization (GO:0032200)2.96277647
104translational initiation (GO:0006413)2.95919912
105meiotic chromosome segregation (GO:0045132)2.94558736
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94511937
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94263247
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94263247
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94263247
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.94263247
111negative regulation of sister chromatid segregation (GO:0033046)2.94263247
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.94243827
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93674067
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93128076
115negative regulation of chromosome segregation (GO:0051985)2.92724495
116regulation of ubiquitin-protein transferase activity (GO:0051438)2.92644876
117protein sumoylation (GO:0016925)2.92595807
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92577706
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.92577706
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.92535579
121mitotic sister chromatid cohesion (GO:0007064)2.92291661
122chaperone-mediated protein transport (GO:0072321)2.91644122
123folic acid-containing compound biosynthetic process (GO:0009396)2.91494982
124negative regulation of RNA splicing (GO:0033119)2.90565494
125formation of translation preinitiation complex (GO:0001731)2.90537848
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90054621
127spliceosomal snRNP assembly (GO:0000387)2.89034843
128histone mRNA metabolic process (GO:0008334)2.88593518
129purine nucleobase biosynthetic process (GO:0009113)2.88530088
130viral mRNA export from host cell nucleus (GO:0046784)2.86909129
131proteasome assembly (GO:0043248)2.86881270
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86812413
133termination of RNA polymerase II transcription (GO:0006369)2.86479195
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85620299
135rRNA modification (GO:0000154)2.85445068
136ribosome assembly (GO:0042255)2.82362716
137DNA duplex unwinding (GO:0032508)2.80913628
138protein localization to endoplasmic reticulum (GO:0070972)2.80369893
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80199768
140establishment of chromosome localization (GO:0051303)2.80183140
141DNA geometric change (GO:0032392)2.79098267
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.78822456
143protein localization to chromosome, centromeric region (GO:0071459)2.78440337
144mismatch repair (GO:0006298)2.77951065
145regulation of histone H3-K9 methylation (GO:0051570)2.77575442
146intra-S DNA damage checkpoint (GO:0031573)2.77117961
147snRNA processing (GO:0016180)2.76579290
148RNA splicing, via transesterification reactions (GO:0000375)2.74260794
149protein K6-linked ubiquitination (GO:0085020)2.72994109
150mRNA splicing, via spliceosome (GO:0000398)2.72987105
151RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72987105
152spliceosomal complex assembly (GO:0000245)2.72559492
153histone exchange (GO:0043486)2.72431128
154termination of RNA polymerase III transcription (GO:0006386)2.71893524
155transcription elongation from RNA polymerase III promoter (GO:0006385)2.71893524
156DNA-templated transcription, termination (GO:0006353)2.71874798
157nuclear envelope disassembly (GO:0051081)2.71708335
158membrane disassembly (GO:0030397)2.71708335
159regulation of helicase activity (GO:0051095)2.68662328
160somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68459502
161somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68459502
162isotype switching (GO:0045190)2.68459502
163cellular protein complex disassembly (GO:0043624)2.68171875
164mRNA catabolic process (GO:0006402)2.68125703
165replication fork processing (GO:0031297)2.67244814
166RNA catabolic process (GO:0006401)2.66961085
167ncRNA processing (GO:0034470)2.66776262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.42421611
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20676192
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82253674
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.25655728
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00083264
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91892110
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.85644955
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85568528
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77946629
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.76554122
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71339783
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70277814
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66724994
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54079138
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53657805
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.50378914
17VDR_23849224_ChIP-Seq_CD4+_Human2.44445775
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.35703992
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29928007
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23553540
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22846242
22FOXP3_21729870_ChIP-Seq_TREG_Human2.20426916
23VDR_22108803_ChIP-Seq_LS180_Human2.20378435
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19369900
25XRN2_22483619_ChIP-Seq_HELA_Human2.18995952
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17160648
27CIITA_25753668_ChIP-Seq_RAJI_Human2.14332766
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.10314523
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.05000314
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04702476
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03856860
32ZNF274_21170338_ChIP-Seq_K562_Hela2.03264373
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02482853
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01014831
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97742618
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96413543
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.94222250
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90595465
39ELK1_19687146_ChIP-ChIP_HELA_Human1.89987318
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89710910
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88804207
42DCP1A_22483619_ChIP-Seq_HELA_Human1.86512282
43MYC_22102868_ChIP-Seq_BL_Human1.85214006
44* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82561201
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81441049
46TTF2_22483619_ChIP-Seq_HELA_Human1.79610651
47* GABP_19822575_ChIP-Seq_HepG2_Human1.78545403
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76266110
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75321963
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73994577
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71288310
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71036446
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70633305
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69933258
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69323021
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69240826
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67855376
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65847061
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.64542020
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53856275
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53003591
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52886025
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49178511
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.47313715
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47145319
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44748793
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.41872270
68AR_21909140_ChIP-Seq_LNCAP_Human1.37312762
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36454002
70KDM5A_27292631_Chip-Seq_BREAST_Human1.32911377
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31399457
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29022325
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27243306
74SPI1_23547873_ChIP-Seq_NB4_Human1.26102643
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19104595
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19104595
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19104595
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17922928
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17834337
80EWS_26573619_Chip-Seq_HEK293_Human1.17189468
81TFEB_21752829_ChIP-Seq_HELA_Human1.16792717
82SCL_19346495_ChIP-Seq_HPC-7_Human1.15877817
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15734589
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15123699
85IRF1_19129219_ChIP-ChIP_H3396_Human1.13850358
86VDR_21846776_ChIP-Seq_THP-1_Human1.13826599
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12437078
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11871982
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.10416909
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09709330
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08596537
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08138700
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06943094
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06637379
95GATA1_22025678_ChIP-Seq_K562_Human1.05942962
96FUS_26573619_Chip-Seq_HEK293_Human1.04573792
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.03370291
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01613359
99MYC_18940864_ChIP-ChIP_HL60_Human1.00202929
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.98244269
101IGF1R_20145208_ChIP-Seq_DFB_Human0.97466332
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97015213
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95805788
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95424553
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.94882626
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94247452
107TAF15_26573619_Chip-Seq_HEK293_Human0.93363070
108MYB_26560356_Chip-Seq_TH1_Human0.93206439
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93190399
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92702749
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91011676
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90747674
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.90057113
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89931879
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89157547
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88845492
117MYB_26560356_Chip-Seq_TH2_Human0.87772225
118TP53_22573176_ChIP-Seq_HFKS_Human0.87365138
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86344568
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85570690
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.84833006
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83866488
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83418085
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80715402
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80122788
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79681899
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79627372
128P300_19829295_ChIP-Seq_ESCs_Human0.79058248
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76837309
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72954123
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70166549
132ELF5_23300383_ChIP-Seq_T47D_Human0.68763204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.18962638
2MP0008057_abnormal_DNA_replication4.18203765
3MP0010094_abnormal_chromosome_stability3.96987882
4MP0008058_abnormal_DNA_repair3.70971251
5MP0002396_abnormal_hematopoietic_system3.50647791
6MP0003111_abnormal_nucleus_morphology3.48875798
7MP0003718_maternal_effect3.42639593
8MP0003077_abnormal_cell_cycle3.26856165
9MP0004957_abnormal_blastocyst_morpholog3.10589441
10MP0008007_abnormal_cellular_replicative2.91361917
11MP0002102_abnormal_ear_morphology2.69648820
12MP0008789_abnormal_olfactory_epithelium2.31377029
13MP0006292_abnormal_olfactory_placode2.29591124
14MP0000490_abnormal_crypts_of2.18034776
15MP0003763_abnormal_thymus_physiology2.15733095
16MP0004808_abnormal_hematopoietic_stem2.10772634
17MP0000372_irregular_coat_pigmentation1.95630599
18MP0003786_premature_aging1.94557145
19MP0008932_abnormal_embryonic_tissue1.88989141
20MP0003950_abnormal_plasma_membrane1.87284785
21MP0002837_dystrophic_cardiac_calcinosis1.78534096
22MP0001919_abnormal_reproductive_system1.75357187
23MP0005394_taste/olfaction_phenotype1.73367663
24MP0005499_abnormal_olfactory_system1.73367663
25MP0002751_abnormal_autonomic_nervous1.72157580
26MP0003303_peritoneal_inflammation1.70502320
27MP0000350_abnormal_cell_proliferation1.68583423
28MP0003123_paternal_imprinting1.67261366
29MP0002398_abnormal_bone_marrow1.65453952
30MP0005075_abnormal_melanosome_morpholog1.61134270
31MP0005397_hematopoietic_system_phenotyp1.59244434
32MP0001545_abnormal_hematopoietic_system1.59244434
33MP0005671_abnormal_response_to1.59201576
34MP0001835_abnormal_antigen_presentation1.57263919
35MP0006035_abnormal_mitochondrial_morpho1.56698907
36MP0008877_abnormal_DNA_methylation1.56124046
37MP0006036_abnormal_mitochondrial_physio1.52879251
38MP0003121_genomic_imprinting1.52647779
39MP0000703_abnormal_thymus_morphology1.50641350
40MP0010352_gastrointestinal_tract_polyps1.49489475
41MP0009333_abnormal_splenocyte_physiolog1.48634986
42MP0003646_muscle_fatigue1.47698177
43MP0001764_abnormal_homeostasis1.45876075
44MP0010307_abnormal_tumor_latency1.45763399
45MP0005174_abnormal_tail_pigmentation1.45027018
46MP0006082_CNS_inflammation1.44037318
47MP0001730_embryonic_growth_arrest1.43522086
48MP0001529_abnormal_vocalization1.42584281
49MP0003186_abnormal_redox_activity1.40789148
50MP0000313_abnormal_cell_death1.39080691
51MP0002095_abnormal_skin_pigmentation1.37775624
52MP0002254_reproductive_system_inflammat1.36593552
53* MP0001293_anophthalmia1.35474496
54MP0002722_abnormal_immune_system1.34386113
55MP0002019_abnormal_tumor_incidence1.32829852
56MP0000685_abnormal_immune_system1.32330068
57MP0000689_abnormal_spleen_morphology1.31799754
58MP0009697_abnormal_copulation1.31410066
59MP0001800_abnormal_humoral_immune1.29153793
60MP0005380_embryogenesis_phenotype1.26660025
61MP0001672_abnormal_embryogenesis/_devel1.26660025
62MP0002938_white_spotting1.26094597
63MP0000716_abnormal_immune_system1.24874810
64MP0003984_embryonic_growth_retardation1.23110454
65MP0001697_abnormal_embryo_size1.22321507
66MP0002429_abnormal_blood_cell1.22050653
67MP0005395_other_phenotype1.21852057
68MP0002166_altered_tumor_susceptibility1.21630907
69MP0000358_abnormal_cell_content/1.20651532
70MP0003937_abnormal_limbs/digits/tail_de1.19451928
71MP0002088_abnormal_embryonic_growth/wei1.19228655
72MP0002006_tumorigenesis1.18369696
73MP0002420_abnormal_adaptive_immunity1.18261732
74MP0001819_abnormal_immune_cell1.16270025
75MP0002452_abnormal_antigen_presenting1.14273933
76MP0004215_abnormal_myocardial_fiber1.11911000
77MP0002080_prenatal_lethality1.09405791
78MP0002723_abnormal_immune_serum1.06698802
79MP0000749_muscle_degeneration1.06086154
80* MP0004197_abnormal_fetal_growth/weight/1.05465605
81MP0001853_heart_inflammation1.04988469
82* MP0002085_abnormal_embryonic_tissue1.04138337
83MP0005423_abnormal_somatic_nervous1.03644636
84* MP0002086_abnormal_extraembryonic_tissu1.03301258
85MP0000647_abnormal_sebaceous_gland1.03264008
86MP0002084_abnormal_developmental_patter1.02196949
87MP0000858_altered_metastatic_potential1.01016206
88MP0002277_abnormal_respiratory_mucosa0.98471387
89MP0003943_abnormal_hepatobiliary_system0.98140349
90MP0003787_abnormal_imprinting0.98066638
91MP0000566_synostosis0.97809354
92MP0000516_abnormal_urinary_system0.97088430
93MP0005367_renal/urinary_system_phenotyp0.97088430
94MP0000467_abnormal_esophagus_morphology0.96035230
95MP0003890_abnormal_embryonic-extraembry0.95363249
96MP0003221_abnormal_cardiomyocyte_apopto0.94234003
97MP0002132_abnormal_respiratory_system0.94232367
98MP0002160_abnormal_reproductive_system0.93735866
99MP0005000_abnormal_immune_tolerance0.93344531
100MP0001986_abnormal_taste_sensitivity0.92607582
101MP0002075_abnormal_coat/hair_pigmentati0.90000399
102* MP0002210_abnormal_sex_determination0.89883447
103MP0001119_abnormal_female_reproductive0.89526296
104MP0002233_abnormal_nose_morphology0.88504060
105MP0003567_abnormal_fetal_cardiomyocyte0.87725779
106MP0003806_abnormal_nucleotide_metabolis0.87264004
107MP0006054_spinal_hemorrhage0.87090912
108MP0000383_abnormal_hair_follicle0.85782305
109MP0003698_abnormal_male_reproductive0.84731951
110MP0003315_abnormal_perineum_morphology0.82088537
111MP0005076_abnormal_cell_differentiation0.81277433
112MP0000015_abnormal_ear_pigmentation0.80986504
113* MP0001145_abnormal_male_reproductive0.80939356
114MP0001984_abnormal_olfaction0.79818266
115MP0003136_yellow_coat_color0.79761787
116MP0002405_respiratory_system_inflammati0.79523519
117MP0004264_abnormal_extraembryonic_tissu0.78802769
118MP0005389_reproductive_system_phenotype0.78307342
119MP0000569_abnormal_digit_pigmentation0.77032774
120MP0005408_hypopigmentation0.76838944
121MP0000465_gastrointestinal_hemorrhage0.76502745
122MP0003941_abnormal_skin_development0.75852329
123MP0004133_heterotaxia0.74835648
124MP0005025_abnormal_response_to0.74422025
125MP0001186_pigmentation_phenotype0.74324667
126MP0002148_abnormal_hypersensitivity_rea0.74136582
127MP0001324_abnormal_eye_pigmentation0.74076332
128* MP0002161_abnormal_fertility/fecundity0.73849069
129MP0003195_calcinosis0.73574924
130MP0010155_abnormal_intestine_physiology0.73150275
131MP0003115_abnormal_respiratory_system0.72852507
132MP0001485_abnormal_pinna_reflex0.72184448
133MP0004084_abnormal_cardiac_muscle0.71200032
134MP0004233_abnormal_muscle_weight0.71148179
135MP0003436_decreased_susceptibility_to0.70349464
136MP0010030_abnormal_orbit_morphology0.68787102
137* MP0000653_abnormal_sex_gland0.68757955
138MP0002111_abnormal_tail_morphology0.68130213
139* MP0001286_abnormal_eye_development0.67891890
140MP0000371_diluted_coat_color0.67738870
141* MP0001929_abnormal_gametogenesis0.66965051
142MP0006072_abnormal_retinal_apoptosis0.66842781
143MP0003699_abnormal_female_reproductive0.66522291
144MP0005384_cellular_phenotype0.66336683
145MP0002009_preneoplasia0.66062415
146MP0001873_stomach_inflammation0.64955818
147MP0002419_abnormal_innate_immunity0.64263521
148MP0008995_early_reproductive_senescence0.63352388
149MP0003866_abnormal_defecation0.62884011
150MP0003119_abnormal_digestive_system0.62829964

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.30182326
2Reticulocytopenia (HP:0001896)3.99273939
3Abnormal number of erythroid precursors (HP:0012131)3.81068367
4Chromsome breakage (HP:0040012)3.77647265
5Abnormality of cells of the erythroid lineage (HP:0012130)3.63863962
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57427693
7Aplastic anemia (HP:0001915)3.55817165
8Hypoplastic pelvis (HP:0008839)3.54127873
9Colon cancer (HP:0003003)3.22108816
10Dry hair (HP:0011359)3.19424253
11Increased serum pyruvate (HP:0003542)3.02999351
12Thrombocytosis (HP:0001894)3.01876430
13Abnormality of chromosome stability (HP:0003220)2.98128696
1411 pairs of ribs (HP:0000878)2.86253663
15Myelodysplasia (HP:0002863)2.84395224
16Acute encephalopathy (HP:0006846)2.82878098
17Meckel diverticulum (HP:0002245)2.81617033
18Medulloblastoma (HP:0002885)2.76963705
19Acute necrotizing encephalopathy (HP:0006965)2.76666712
20Abnormality of the ileum (HP:0001549)2.75654144
21Type I transferrin isoform profile (HP:0003642)2.74580054
22Abnormality of the preputium (HP:0100587)2.70992125
23Abnormality of glycolysis (HP:0004366)2.70914467
24Progressive muscle weakness (HP:0003323)2.63053861
25Patellar aplasia (HP:0006443)2.62915701
26Abnormality of the columella (HP:0009929)2.61494112
27Abnormality of the labia minora (HP:0012880)2.61391737
28Abnormality of methionine metabolism (HP:0010901)2.60645606
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.58901349
30Methylmalonic acidemia (HP:0002912)2.58726820
31Pallor (HP:0000980)2.58351901
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.57383705
33Oral leukoplakia (HP:0002745)2.56578419
34Limb hypertonia (HP:0002509)2.56382202
35Agnosia (HP:0010524)2.55317164
36Ectopic kidney (HP:0000086)2.53186154
37Premature graying of hair (HP:0002216)2.50792137
38Glioma (HP:0009733)2.50017164
39Abnormality of the fingertips (HP:0001211)2.48975308
40IgM deficiency (HP:0002850)2.48822816
41Aplasia/Hypoplasia of the patella (HP:0006498)2.47742578
42Increased CSF lactate (HP:0002490)2.47023211
43Microvesicular hepatic steatosis (HP:0001414)2.44518101
44Increased serum lactate (HP:0002151)2.43147086
45Acute lymphatic leukemia (HP:0006721)2.40339750
46Abnormality of the astrocytes (HP:0100707)2.40302182
47Astrocytoma (HP:0009592)2.40302182
48Increased hepatocellular lipid droplets (HP:0006565)2.40241692
49Selective tooth agenesis (HP:0001592)2.39421455
50Abnormal mitochondria in muscle tissue (HP:0008316)2.36470151
51Optic nerve coloboma (HP:0000588)2.35655015
52Lactic acidosis (HP:0003128)2.32862268
53Bone marrow hypocellularity (HP:0005528)2.32125361
54Lymphoma (HP:0002665)2.30614509
55Progressive macrocephaly (HP:0004481)2.29454227
56Calf muscle hypertrophy (HP:0008981)2.28366110
57Acute myeloid leukemia (HP:0004808)2.27637247
58Hypoplasia of the pons (HP:0012110)2.26069220
59Macrocytic anemia (HP:0001972)2.24146356
60Abnormal number of incisors (HP:0011064)2.22569338
61Small intestinal stenosis (HP:0012848)2.20811181
62Duodenal stenosis (HP:0100867)2.20811181
63Mitochondrial inheritance (HP:0001427)2.20732128
64Clubbing of toes (HP:0100760)2.20437665
65Abnormality of DNA repair (HP:0003254)2.19841931
66Absent thumb (HP:0009777)2.19469258
67Exercise-induced muscle cramps (HP:0003710)2.16672509
68Supernumerary spleens (HP:0009799)2.16599384
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16109917
70Abnormal protein glycosylation (HP:0012346)2.15465351
71Abnormal glycosylation (HP:0012345)2.15465351
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15465351
73Abnormal protein N-linked glycosylation (HP:0012347)2.15465351
74Sloping forehead (HP:0000340)2.14121934
75Amaurosis fugax (HP:0100576)2.12956638
76Adactyly (HP:0009776)2.11750448
77Prominent nose (HP:0000448)2.09000837
78Methylmalonic aciduria (HP:0012120)2.08702998
79Muscle hypertrophy of the lower extremities (HP:0008968)2.06540358
80Long eyelashes (HP:0000527)2.06121379
81Volvulus (HP:0002580)2.05337372
82Cerebral edema (HP:0002181)2.04713480
83Abnormality of the prostate (HP:0008775)2.04708056
84Lipid accumulation in hepatocytes (HP:0006561)2.02895048
85Female pseudohermaphroditism (HP:0010458)2.02881070
86Asplenia (HP:0001746)2.02820255
87Long foot (HP:0001833)2.01665127
88Hyperglycinemia (HP:0002154)2.01642751
89Abnormal ventriculo-arterial connection (HP:0011563)2.00246637
90Transposition of the great arteries (HP:0001669)2.00246637
91Abnormal connection of the cardiac segments (HP:0011545)2.00246637
92Abnormality of the carotid arteries (HP:0005344)1.98374559
93Ureteral duplication (HP:0000073)1.98238888
94Brushfield spots (HP:0001088)1.97018667
95Abnormality of the pons (HP:0007361)1.96940617
96Reduced antithrombin III activity (HP:0001976)1.96067789
97Neoplasm of the oral cavity (HP:0100649)1.96021207
98Type 2 muscle fiber atrophy (HP:0003554)1.95163590
99Short middle phalanx of the 5th finger (HP:0004220)1.94979546
100Triphalangeal thumb (HP:0001199)1.93904222
101Abnormality of the duodenum (HP:0002246)1.93003543
102Rectovaginal fistula (HP:0000143)1.92821505
103Rectal fistula (HP:0100590)1.92821505
104Abnormal lung lobation (HP:0002101)1.92574148
105Abnormality of the anterior horn cell (HP:0006802)1.92565465
106Degeneration of anterior horn cells (HP:0002398)1.92565465
107Renal cortical cysts (HP:0000803)1.91065604
108Rough bone trabeculation (HP:0100670)1.91005191
109Megaloblastic anemia (HP:0001889)1.90175752
110Nephroblastoma (Wilms tumor) (HP:0002667)1.88815696
111Muscle fiber atrophy (HP:0100295)1.88503442
112Abnormality of fatty-acid metabolism (HP:0004359)1.87328902
113Cellular immunodeficiency (HP:0005374)1.86741440
114Pancytopenia (HP:0001876)1.85741296
115Breast hypoplasia (HP:0003187)1.85376014
116Neoplasm of the pancreas (HP:0002894)1.85019929
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.83560018
118Abnormality of homocysteine metabolism (HP:0010919)1.83110146
119Homocystinuria (HP:0002156)1.83110146
120Short tibia (HP:0005736)1.82576209
121Oligodactyly (hands) (HP:0001180)1.81877929
122Abnormality of serum amino acid levels (HP:0003112)1.81725393
123Ependymoma (HP:0002888)1.81512434
124Renal Fanconi syndrome (HP:0001994)1.81214507
125Rhabdomyosarcoma (HP:0002859)1.80838798
126Tracheoesophageal fistula (HP:0002575)1.79028256
127Exercise intolerance (HP:0003546)1.78824881
128Microretrognathia (HP:0000308)1.78710682
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.78591812
130Basal cell carcinoma (HP:0002671)1.77195116
131Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77160507
132Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77160507
133Duplicated collecting system (HP:0000081)1.77125474
134Abnormality of the heme biosynthetic pathway (HP:0010472)1.76822722
135Hepatic necrosis (HP:0002605)1.76284772
136Abnormality of the renal collecting system (HP:0004742)1.74918276
137Nausea (HP:0002018)1.74136147
138Septate vagina (HP:0001153)1.73632451
139Carpal bone hypoplasia (HP:0001498)1.72947337
140Embryonal renal neoplasm (HP:0011794)1.72844633
141Exertional dyspnea (HP:0002875)1.72124467
142IgG deficiency (HP:0004315)1.71383835
143Cleft eyelid (HP:0000625)1.71381505
144Horseshoe kidney (HP:0000085)1.70933504
145Poor suck (HP:0002033)1.70826817
146Abnormality of vitamin B metabolism (HP:0004340)1.70467842
147Intestinal atresia (HP:0011100)1.70291050
148Secondary amenorrhea (HP:0000869)1.69360662
149Hyperalaninemia (HP:0003348)1.69221483
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69221483
151Panhypogammaglobulinemia (HP:0003139)1.68718507
152Leukopenia (HP:0001882)1.68649221
153Elevated erythrocyte sedimentation rate (HP:0003565)1.67128643
154Increased nuchal translucency (HP:0010880)1.65684271
155Short thumb (HP:0009778)1.64551860
156Abnormality of T cell physiology (HP:0011840)1.62852733
157Recurrent viral infections (HP:0004429)1.62295212
158Abnormality of T cells (HP:0002843)1.59979878
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59785616
160Chronic otitis media (HP:0000389)1.59298801
161B lymphocytopenia (HP:0010976)1.58629556
162Abnormality of B cell number (HP:0010975)1.58629556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.31136829
2CDC73.30977053
3WEE13.00923100
4TAOK12.69478475
5BUB12.67339115
6VRK22.56453732
7VRK12.52684390
8TRIM282.42912646
9STK162.40852038
10EIF2AK12.29219771
11BRD42.28433424
12ZAK2.22255717
13MKNK12.18100606
14TLK12.17378861
15MST42.16573259
16MKNK22.11364602
17ACVR1B2.09107895
18ATR2.07562938
19PBK2.06249477
20DYRK32.03556058
21NEK21.99190280
22NME21.97754147
23CDK121.92663376
24EIF2AK31.91056269
25PLK41.89458122
26CDK71.80594153
27TEC1.74332191
28BRSK21.63593754
29FLT31.60704658
30PASK1.59251777
31IRAK41.52962069
32TSSK61.51921112
33PLK11.43976246
34MAP4K11.43358207
35NEK11.42224160
36MAP3K31.42122030
37WNK31.39826668
38CHEK21.36260794
39PIM21.35725274
40RPS6KA41.34612335
41EIF2AK21.32210454
42AURKB1.29593674
43TTK1.28370757
44RPS6KB21.27726057
45TXK1.19814909
46PIM11.17069370
47PLK31.15012011
48EPHA21.13847803
49TNIK1.13739552
50PDK21.12668671
51BTK1.12455573
52TGFBR11.10104445
53STK101.07484628
54NME11.07041900
55ATM1.05063397
56CHEK11.04780435
57SIK31.02752594
58CCNB11.02023890
59KIT1.01607358
60MAP3K111.00010477
61NLK0.99537792
62STK40.98900955
63TAF10.93735662
64ABL20.92212157
65CDK40.91685647
66MAP3K50.89022219
67MAP3K140.88038560
68MAP3K40.87508504
69IKBKB0.84948644
70CDK80.84708789
71JAK30.82654375
72IRAK30.81973837
73PNCK0.81642888
74ZAP700.78304813
75CLK10.77903916
76MAP2K30.76739743
77BCR0.75998321
78CDK20.74684340
79RPS6KA50.74363788
80ERBB30.72742304
81MUSK0.72259873
82BCKDK0.71939657
83MAP2K70.70318119
84YES10.70073634
85TESK20.68080084
86CHUK0.65649377
87MAP3K80.65301599
88OXSR10.64879716
89AURKA0.64528046
90NEK90.63859009
91BLK0.63461280
92CSF1R0.61144461
93NUAK10.60093073
94CSNK2A20.59500537
95BRSK10.58457955
96CSNK1G10.58409789
97MAP4K20.58162613
98DYRK1A0.57706646
99CSNK2A10.57225828
100CSNK1G30.55088037
101CDK30.53885611
102CSNK1G20.53520882
103CDK10.52610760
104LYN0.52043496
105SYK0.51645173
106TAOK20.51302931
107GRK10.49050112
108ADRBK20.46597525
109MAPKAPK50.46464263
110FRK0.46244381
111STK38L0.46211713
112RPS6KB10.44356994
113MARK30.44133034
114SCYL20.43866814
115NEK60.43415659
116TYK20.40437607
117STK30.39144644
118KDR0.38743471
119IKBKE0.38348893
120LCK0.38270268
121PLK20.37296945
122EPHA40.36830826
123ERBB40.36118037
124PIK3CA0.35635681
125CDK190.35482004
126PRKDC0.35447152
127CDK60.34414778
128INSRR0.33903537
129CDK90.33385947
130FGR0.33208279
131PRKCI0.32859320
132MAPK140.32633964
133PAK30.31726401
134ITK0.30955247
135DYRK20.30148550
136RPS6KA60.29906688
137CSNK1A10.29793652
138RPS6KL10.29563253
139RPS6KC10.29563253
140CSNK1E0.29503420
141OBSCN0.28299323
142MAPK30.27872276
143CSNK1A1L0.27821057
144TAOK30.27728143
145MAP3K120.27603463
146MAPK130.23464522

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25717693
2Mismatch repair_Homo sapiens_hsa034303.63534408
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35789321
4Ribosome_Homo sapiens_hsa030103.27313856
5Spliceosome_Homo sapiens_hsa030403.05660045
6Base excision repair_Homo sapiens_hsa034103.02597808
7RNA polymerase_Homo sapiens_hsa030202.97686639
8Homologous recombination_Homo sapiens_hsa034402.90481333
9Non-homologous end-joining_Homo sapiens_hsa034502.67420838
10Fanconi anemia pathway_Homo sapiens_hsa034602.60454985
11RNA transport_Homo sapiens_hsa030132.47860914
12Nucleotide excision repair_Homo sapiens_hsa034202.41318913
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40725844
14Cell cycle_Homo sapiens_hsa041102.30363303
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28380852
16Pyrimidine metabolism_Homo sapiens_hsa002402.24903115
17Propanoate metabolism_Homo sapiens_hsa006402.19826567
18One carbon pool by folate_Homo sapiens_hsa006702.13295831
19RNA degradation_Homo sapiens_hsa030182.12989882
20Basal transcription factors_Homo sapiens_hsa030222.11463426
21Fatty acid elongation_Homo sapiens_hsa000622.05621432
22Oxidative phosphorylation_Homo sapiens_hsa001902.02141107
23Proteasome_Homo sapiens_hsa030502.00032159
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88752231
25Parkinsons disease_Homo sapiens_hsa050121.82536423
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76653607
27mRNA surveillance pathway_Homo sapiens_hsa030151.67938522
28Herpes simplex infection_Homo sapiens_hsa051681.53674996
29Protein export_Homo sapiens_hsa030601.51570010
30p53 signaling pathway_Homo sapiens_hsa041151.49609792
31Steroid biosynthesis_Homo sapiens_hsa001001.48235024
32Primary immunodeficiency_Homo sapiens_hsa053401.47833244
33Pyruvate metabolism_Homo sapiens_hsa006201.46316814
34Systemic lupus erythematosus_Homo sapiens_hsa053221.41062208
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39635731
36Huntingtons disease_Homo sapiens_hsa050161.32949361
37Purine metabolism_Homo sapiens_hsa002301.29322833
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27177313
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21056249
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12336923
41Epstein-Barr virus infection_Homo sapiens_hsa051691.10737066
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07730707
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07635356
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.07313323
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05305852
46Antigen processing and presentation_Homo sapiens_hsa046121.04943778
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04009762
48Glutathione metabolism_Homo sapiens_hsa004801.02284058
49Measles_Homo sapiens_hsa051621.01446156
50N-Glycan biosynthesis_Homo sapiens_hsa005100.92177539
51Viral carcinogenesis_Homo sapiens_hsa052030.90997039
52Vitamin B6 metabolism_Homo sapiens_hsa007500.90776131
53Alzheimers disease_Homo sapiens_hsa050100.87215294
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86971655
55HTLV-I infection_Homo sapiens_hsa051660.85158460
56Carbon metabolism_Homo sapiens_hsa012000.82837321
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80800769
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.78011086
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77543071
60Hematopoietic cell lineage_Homo sapiens_hsa046400.76042455
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75065032
62Vitamin digestion and absorption_Homo sapiens_hsa049770.74503778
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73860112
64beta-Alanine metabolism_Homo sapiens_hsa004100.72655918
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72547457
66Tryptophan metabolism_Homo sapiens_hsa003800.72240707
67Butanoate metabolism_Homo sapiens_hsa006500.70765054
68Allograft rejection_Homo sapiens_hsa053300.68200723
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68121818
70Metabolic pathways_Homo sapiens_hsa011000.66293629
71Hepatitis B_Homo sapiens_hsa051610.64676432
72Collecting duct acid secretion_Homo sapiens_hsa049660.64061447
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63823826
74Legionellosis_Homo sapiens_hsa051340.62335074
75Apoptosis_Homo sapiens_hsa042100.61028197
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60688971
77Acute myeloid leukemia_Homo sapiens_hsa052210.59799903
78Alcoholism_Homo sapiens_hsa050340.59012847
79Notch signaling pathway_Homo sapiens_hsa043300.58990903
80MicroRNAs in cancer_Homo sapiens_hsa052060.58019830
81Peroxisome_Homo sapiens_hsa041460.57884334
82Selenocompound metabolism_Homo sapiens_hsa004500.57753337
83Influenza A_Homo sapiens_hsa051640.57422515
84Leishmaniasis_Homo sapiens_hsa051400.56986700
85Folate biosynthesis_Homo sapiens_hsa007900.56095624
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.55924087
87Thyroid cancer_Homo sapiens_hsa052160.55714640
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55584452
89B cell receptor signaling pathway_Homo sapiens_hsa046620.55059544
90Sulfur metabolism_Homo sapiens_hsa009200.54836797
91Regulation of autophagy_Homo sapiens_hsa041400.52453531
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51727156
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51528610
94Colorectal cancer_Homo sapiens_hsa052100.50771482
95Shigellosis_Homo sapiens_hsa051310.50489690
96Small cell lung cancer_Homo sapiens_hsa052220.49987476
97Fatty acid metabolism_Homo sapiens_hsa012120.49927871
98Biosynthesis of amino acids_Homo sapiens_hsa012300.49207164
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47376739
100Arginine and proline metabolism_Homo sapiens_hsa003300.44515677
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43003958
102Pentose phosphate pathway_Homo sapiens_hsa000300.42514781
103Basal cell carcinoma_Homo sapiens_hsa052170.42456522
104T cell receptor signaling pathway_Homo sapiens_hsa046600.39685225
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39421629
106Sulfur relay system_Homo sapiens_hsa041220.39226146
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39157157
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38973697
109Oocyte meiosis_Homo sapiens_hsa041140.38819577
110Chronic myeloid leukemia_Homo sapiens_hsa052200.38585752
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38223883
112TGF-beta signaling pathway_Homo sapiens_hsa043500.37340889
113Asthma_Homo sapiens_hsa053100.37336696
114Phototransduction_Homo sapiens_hsa047440.37130457
115Type I diabetes mellitus_Homo sapiens_hsa049400.36247445
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35980145
117Cardiac muscle contraction_Homo sapiens_hsa042600.35491639
118Lysine degradation_Homo sapiens_hsa003100.33738647
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33330505
120Other glycan degradation_Homo sapiens_hsa005110.32780902
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32189093
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.31897416
123Taste transduction_Homo sapiens_hsa047420.31548180
124Autoimmune thyroid disease_Homo sapiens_hsa053200.31463775
125Pathways in cancer_Homo sapiens_hsa052000.29638274
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29447191
127TNF signaling pathway_Homo sapiens_hsa046680.28291092
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28072150
129Fatty acid degradation_Homo sapiens_hsa000710.26989939
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.26810851
131Wnt signaling pathway_Homo sapiens_hsa043100.26781457
132Prostate cancer_Homo sapiens_hsa052150.25595762
133Graft-versus-host disease_Homo sapiens_hsa053320.25173664
134Osteoclast differentiation_Homo sapiens_hsa043800.23950433
135Viral myocarditis_Homo sapiens_hsa054160.23672962
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23309392
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.23017178
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21926599
139Ether lipid metabolism_Homo sapiens_hsa005650.21573271
140Galactose metabolism_Homo sapiens_hsa000520.21222989
141Toxoplasmosis_Homo sapiens_hsa051450.20707830
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12386547
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.12382953
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09237799
145Sphingolipid metabolism_Homo sapiens_hsa006000.08898905
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06840275
147Caffeine metabolism_Homo sapiens_hsa002320.06010490
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04780875
149Glycerolipid metabolism_Homo sapiens_hsa005610.04066836

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