ALKBH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.34517772
2proline metabolic process (GO:0006560)8.14220542
3replication fork processing (GO:0031297)7.66419163
4embryonic process involved in female pregnancy (GO:0060136)7.66408212
5DNA deamination (GO:0045006)7.12559547
6positive regulation of protein homooligomerization (GO:0032464)6.76018439
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.39057382
8regulation of integrin activation (GO:0033623)6.06575731
9establishment of apical/basal cell polarity (GO:0035089)6.03962797
10regulation of protein homooligomerization (GO:0032462)5.79552612
11mitochondrial DNA metabolic process (GO:0032042)5.58583619
12somatic diversification of immune receptors via somatic mutation (GO:0002566)5.48813776
13somatic hypermutation of immunoglobulin genes (GO:0016446)5.48813776
14DNA strand renaturation (GO:0000733)5.36028370
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.24029070
16establishment of monopolar cell polarity (GO:0061162)5.24029070
17mitotic G1 DNA damage checkpoint (GO:0031571)5.09534901
18poly(A)+ mRNA export from nucleus (GO:0016973)5.08860533
19viral mRNA export from host cell nucleus (GO:0046784)4.89480300
20negative regulation of JAK-STAT cascade (GO:0046426)4.67306246
21formation of translation preinitiation complex (GO:0001731)4.60820749
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.57284914
23ribosomal small subunit assembly (GO:0000028)4.53665867
24G1 DNA damage checkpoint (GO:0044783)4.52276609
25mRNA cleavage (GO:0006379)4.50499774
26mitotic G1/S transition checkpoint (GO:0044819)4.49729697
27negative regulation of cell cycle arrest (GO:0071157)4.47839321
28cellular response to ATP (GO:0071318)4.45774896
29maturation of SSU-rRNA (GO:0030490)4.45578598
30embryonic placenta development (GO:0001892)4.44604752
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.41696548
32ribosomal large subunit biogenesis (GO:0042273)4.34152994
33regulation of translational fidelity (GO:0006450)4.31744708
34glutamine family amino acid biosynthetic process (GO:0009084)4.30010867
35telomere maintenance via semi-conservative replication (GO:0032201)4.26980097
36base-excision repair (GO:0006284)4.22474081
37DNA integration (GO:0015074)4.21743887
38regulation of mitochondrial translation (GO:0070129)4.17385415
39negative regulation of fatty acid biosynthetic process (GO:0045717)4.14362692
40viral transcription (GO:0019083)4.10285781
41spliceosomal tri-snRNP complex assembly (GO:0000244)4.02840757
42translational termination (GO:0006415)4.00913899
43ribosomal small subunit biogenesis (GO:0042274)3.99015260
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.97473979
45positive regulation of protein oligomerization (GO:0032461)3.92561251
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.91942656
47negative regulation of Ras GTPase activity (GO:0034261)3.91806060
48negative regulation of protein oligomerization (GO:0032460)3.91355395
49positive regulation of developmental pigmentation (GO:0048087)3.88278411
50non-recombinational repair (GO:0000726)3.86844646
51double-strand break repair via nonhomologous end joining (GO:0006303)3.86844646
52mitochondrial RNA metabolic process (GO:0000959)3.84958164
53DNA double-strand break processing (GO:0000729)3.84679251
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.83289068
55proteasome assembly (GO:0043248)3.83020371
56ATP synthesis coupled proton transport (GO:0015986)3.82203751
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.82203751
58cellular response to zinc ion (GO:0071294)3.80041514
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.79577370
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79577370
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79577370
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78570093
63base-excision repair, AP site formation (GO:0006285)3.77522561
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.75934557
65establishment of integrated proviral latency (GO:0075713)3.73863207
66dosage compensation (GO:0007549)3.73421215
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.72586312
68GDP-mannose metabolic process (GO:0019673)3.71966561
69meiotic chromosome segregation (GO:0045132)3.71194029
70cotranslational protein targeting to membrane (GO:0006613)3.70577762
71regulation of protein oligomerization (GO:0032459)3.70323644
72ribonucleoprotein complex biogenesis (GO:0022613)3.68485237
73histone H4-K12 acetylation (GO:0043983)3.66092655
74positive regulation by host of viral transcription (GO:0043923)3.65385104
75maturation of 5.8S rRNA (GO:0000460)3.65148017
76regulation of sister chromatid cohesion (GO:0007063)3.64201146
77rRNA modification (GO:0000154)3.62944624
78protein targeting to ER (GO:0045047)3.62673895
79translational elongation (GO:0006414)3.62218793
80embryonic camera-type eye development (GO:0031076)3.60918121
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58238436
82termination of RNA polymerase II transcription (GO:0006369)3.56969976
83oxidative phosphorylation (GO:0006119)3.55873048
84face development (GO:0060324)3.55681897
85peptidyl-histidine modification (GO:0018202)3.54433372
86DNA replication checkpoint (GO:0000076)3.54245655
87regulation of RNA export from nucleus (GO:0046831)3.53858666
88negative regulation of mRNA processing (GO:0050686)3.53301134
89convergent extension (GO:0060026)3.52705177
90spliceosomal snRNP assembly (GO:0000387)3.52380466
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.52283189
92termination of RNA polymerase III transcription (GO:0006386)3.52283189
93chromatin remodeling at centromere (GO:0031055)3.49986377
94translational initiation (GO:0006413)3.48013255
95protein localization to endoplasmic reticulum (GO:0070972)3.47617774
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46808199
97trophectodermal cell differentiation (GO:0001829)3.46546319
98labyrinthine layer development (GO:0060711)3.46457255
99mitotic recombination (GO:0006312)3.45865777
100cellular component biogenesis (GO:0044085)3.44605819
101positive regulation of DNA repair (GO:0045739)3.44514656
102DNA strand elongation involved in DNA replication (GO:0006271)3.44312204
103telomere maintenance via recombination (GO:0000722)3.44167968
104CENP-A containing nucleosome assembly (GO:0034080)3.42594010
105rRNA processing (GO:0006364)3.42174939
106ribosome biogenesis (GO:0042254)3.42102786
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40670915
108regulation of double-strand break repair (GO:2000779)3.40632874
109glial cell migration (GO:0008347)3.40113040
110chaperone-mediated protein transport (GO:0072321)3.38643862
111protein deneddylation (GO:0000338)3.38631149
112nucleobase biosynthetic process (GO:0046112)3.38148963
113DNA topological change (GO:0006265)3.37605987
114DNA replication-dependent nucleosome assembly (GO:0006335)3.37313983
115DNA replication-dependent nucleosome organization (GO:0034723)3.37313983
116kinetochore assembly (GO:0051382)3.36704678
117cullin deneddylation (GO:0010388)3.36576951
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34703204
119pseudouridine synthesis (GO:0001522)3.34660175
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33897223
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33332317
122translation (GO:0006412)3.32442735
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32130046
124ribosome assembly (GO:0042255)3.31601850
125apoptotic process involved in morphogenesis (GO:0060561)3.31106343
126nodal signaling pathway (GO:0038092)3.30794265
127DNA catabolic process, exonucleolytic (GO:0000738)3.30009519
128DNA ligation (GO:0006266)3.29802750
129mitochondrial respiratory chain complex assembly (GO:0033108)3.29026709
130purine nucleobase biosynthetic process (GO:0009113)3.28431578
131rRNA metabolic process (GO:0016072)3.28076771
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28003753
133negative regulation of ligase activity (GO:0051352)3.28003753
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27945769
135DNA strand elongation (GO:0022616)3.23768799
136protein complex biogenesis (GO:0070271)3.21627691
137regulation of posttranscriptional gene silencing (GO:0060147)3.20200779
138regulation of gene silencing by miRNA (GO:0060964)3.20200779
139regulation of gene silencing by RNA (GO:0060966)3.20200779
140viral life cycle (GO:0019058)3.19360016
141anatomical structure regression (GO:0060033)3.19041328
142inner mitochondrial membrane organization (GO:0007007)3.17171578
143transcription-coupled nucleotide-excision repair (GO:0006283)3.15799047
144establishment of viral latency (GO:0019043)3.14879872
145mitochondrial DNA replication (GO:0006264)3.13658819
146telomere maintenance via telomere lengthening (GO:0010833)3.12750369
147resolution of meiotic recombination intermediates (GO:0000712)3.12618616
148cellular protein complex disassembly (GO:0043624)3.10931920
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10146881
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10146881
151mitochondrial respiratory chain complex I assembly (GO:0032981)3.09781380
152NADH dehydrogenase complex assembly (GO:0010257)3.09781380
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09781380
154mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08735569
155negative regulation of RNA splicing (GO:0033119)3.07721631
156regulation of DNA damage checkpoint (GO:2000001)3.06617151
157pyrimidine nucleotide catabolic process (GO:0006244)3.06327690
158mitotic nuclear envelope reassembly (GO:0007084)3.05563833
159nuclear envelope reassembly (GO:0031468)3.05563833
160negative regulation of heart rate (GO:0010459)3.04510922
161protein targeting to mitochondrion (GO:0006626)3.04463674
162activation of Rac GTPase activity (GO:0032863)3.04153559
163positive regulation of chromosome segregation (GO:0051984)3.04153136
164respiratory electron transport chain (GO:0022904)3.03401175
165mitotic metaphase plate congression (GO:0007080)2.99213137
166electron transport chain (GO:0022900)2.96757077
167mRNA polyadenylation (GO:0006378)2.96720378
168regulation of cell size (GO:0008361)2.95639311
169regulation of cAMP-dependent protein kinase activity (GO:2000479)2.94903201
170deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93857557
171DNA unwinding involved in DNA replication (GO:0006268)2.93690821
172negative regulation of appetite (GO:0032099)2.93320091
173negative regulation of response to food (GO:0032096)2.93320091
174signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92411898
175signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92411898
176signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92411898
177DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92163553
178kinetochore organization (GO:0051383)2.91180318
179positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91162111
180DNA replication initiation (GO:0006270)2.91006318
181proline biosynthetic process (GO:0006561)10.6725294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83050936
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.03054885
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.95549113
4CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41781003
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.33818813
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22935421
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.15604155
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.15604155
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.15604155
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14385530
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.97926565
12* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86305270
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83299776
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75932093
15E2F7_22180533_ChIP-Seq_HELA_Human2.70247552
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66042613
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46369629
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45556379
19FOXP3_21729870_ChIP-Seq_TREG_Human2.44958895
20* VDR_23849224_ChIP-Seq_CD4+_Human2.44651722
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43798378
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42935923
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.40879472
24VDR_21846776_ChIP-Seq_THP-1_Human2.33089085
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.32498922
26ELK1_19687146_ChIP-ChIP_HELA_Human2.32003946
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.28027768
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27221510
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23549716
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22969598
31* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.21089933
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17049807
33* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.12028732
34POU5F1_16518401_ChIP-PET_MESCs_Mouse2.09715297
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04006744
36TCF3_18692474_ChIP-Seq_MESCs_Mouse2.03097284
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02522544
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93925093
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92737204
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88172217
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86132566
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83714297
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81248819
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.81229309
45NANOG_21062744_ChIP-ChIP_HESCs_Human1.78509336
46AR_21909140_ChIP-Seq_LNCAP_Human1.77496396
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.77345145
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77066889
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76721355
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76704516
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.76240948
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76152064
53LXR_22292898_ChIP-Seq_THP-1_Human1.76151807
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75489240
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72234738
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.71146180
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64742249
58MYC_18940864_ChIP-ChIP_HL60_Human1.62910362
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62017208
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60310945
61MYC_22102868_ChIP-Seq_BL_Human1.57751179
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56844560
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56432202
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53976956
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51745874
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.48589491
67ZNF263_19887448_ChIP-Seq_K562_Human1.47737002
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46965626
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44545759
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44305409
71* TET1_21451524_ChIP-Seq_MESCs_Mouse1.44184022
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.43854342
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43046091
74* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42985798
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40685718
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40377219
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39805717
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38901735
79* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38763596
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37258383
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36993501
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36682858
83RACK7_27058665_Chip-Seq_MCF-7_Human1.34650763
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33086168
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32695389
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30881422
87* GABP_19822575_ChIP-Seq_HepG2_Human1.30611627
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27252486
89NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26431612
90DCP1A_22483619_ChIP-Seq_HELA_Human1.26350653
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26341810
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26125719
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25391960
94* NOTCH1_21737748_ChIP-Seq_TLL_Human1.24875755
95RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24355664
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24219350
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23388460
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21878951
99ETS1_21867929_ChIP-Seq_TH2_Mouse1.20779967
100KDM5A_27292631_Chip-Seq_BREAST_Human1.19666942
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19163836
102* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18873726
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18442118
104CIITA_25753668_ChIP-Seq_RAJI_Human1.18209685
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17939105
106RARB_24833708_ChIP-Seq_LIVER_Mouse1.17712114
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17490233
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15122418
109* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14418846
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14051895
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13532797
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13142052
113XRN2_22483619_ChIP-Seq_HELA_Human1.12555390
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11849116
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10386760
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09495162
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09159595
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08719599
119* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08237301
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07099827
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06759790
122KDM2B_26808549_Chip-Seq_DND41_Human1.06087318
123* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05532614
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.05222990
125SPI1_26923725_Chip-Seq_HPCs_Mouse1.04994426
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04687396
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04582874
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03992570
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03742853
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02822789
131* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02513899
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02111413
133ELK1_22589737_ChIP-Seq_MCF10A_Human1.01733199
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01263426
135NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00725023
136KAP1_27257070_Chip-Seq_ESCs_Mouse1.00665155
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00156575
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.99538236
139* TTF2_22483619_ChIP-Seq_HELA_Human0.99532476
140PHF8_20622854_ChIP-Seq_HELA_Human0.99501656
141IRF1_19129219_ChIP-ChIP_H3396_Human0.96902876
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91564903
143ZNF274_21170338_ChIP-Seq_K562_Hela0.89746088
144FOXP1_21924763_ChIP-Seq_HESCs_Human0.88134161
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87114252
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.86543946
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86384987
148* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85838047
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85777765
150* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84471162
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.83085352
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81895920
153TFEB_21752829_ChIP-Seq_HELA_Human0.81859956
154HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80344510
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79401418
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77463461
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.76711233
158TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75364025
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74668972
160* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72504569
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71363929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.39139433
2MP0005171_absent_coat_pigmentation4.45302710
3MP0009278_abnormal_bone_marrow4.24115109
4MP0010030_abnormal_orbit_morphology3.78468559
5MP0004233_abnormal_muscle_weight3.32208006
6MP0006292_abnormal_olfactory_placode3.28523666
7MP0002009_preneoplasia3.16954616
8MP0010094_abnormal_chromosome_stability2.70906977
9MP0009379_abnormal_foot_pigmentation2.67010916
10MP0008995_early_reproductive_senescence2.63185430
11MP0003890_abnormal_embryonic-extraembry2.53516768
12MP0008007_abnormal_cellular_replicative2.36778269
13MP0009697_abnormal_copulation2.36245826
14MP0004957_abnormal_blastocyst_morpholog2.33921190
15MP0001545_abnormal_hematopoietic_system2.31746683
16MP0005397_hematopoietic_system_phenotyp2.31746683
17MP0004133_heterotaxia2.30187150
18MP0003283_abnormal_digestive_organ2.29984332
19MP0001529_abnormal_vocalization2.20408404
20MP0003186_abnormal_redox_activity2.18315921
21MP0003786_premature_aging2.17732437
22MP0002653_abnormal_ependyma_morphology2.15477836
23MP0005174_abnormal_tail_pigmentation2.06586610
24MP0006035_abnormal_mitochondrial_morpho2.06567292
25MP0003119_abnormal_digestive_system2.04381925
26MP0002938_white_spotting1.98078291
27MP0006036_abnormal_mitochondrial_physio1.97790336
28MP0006072_abnormal_retinal_apoptosis1.96075594
29MP0003111_abnormal_nucleus_morphology1.92768725
30MP0008877_abnormal_DNA_methylation1.91962655
31MP0008875_abnormal_xenobiotic_pharmacok1.90876229
32MP0002249_abnormal_larynx_morphology1.87399866
33MP0008789_abnormal_olfactory_epithelium1.77965383
34MP0003453_abnormal_keratinocyte_physiol1.75741362
35MP0010352_gastrointestinal_tract_polyps1.70179314
36MP0002086_abnormal_extraembryonic_tissu1.69873868
37MP0008932_abnormal_embryonic_tissue1.67909561
38MP0002282_abnormal_trachea_morphology1.65498972
39MP0002084_abnormal_developmental_patter1.64569616
40MP0001293_anophthalmia1.64345614
41MP0001697_abnormal_embryo_size1.63177925
42MP0005076_abnormal_cell_differentiation1.61634438
43MP0003693_abnormal_embryo_hatching1.59777572
44MP0002234_abnormal_pharynx_morphology1.55290389
45MP0003077_abnormal_cell_cycle1.54130625
46MP0000579_abnormal_nail_morphology1.53354269
47MP0000490_abnormal_crypts_of1.52238187
48MP0002085_abnormal_embryonic_tissue1.50553138
49MP0005075_abnormal_melanosome_morpholog1.49246769
50MP0003172_abnormal_lysosome_physiology1.48631856
51MP0003136_yellow_coat_color1.47518338
52MP0000358_abnormal_cell_content/1.46867650
53MP0004197_abnormal_fetal_growth/weight/1.44950658
54MP0003567_abnormal_fetal_cardiomyocyte1.43644093
55MP0002210_abnormal_sex_determination1.41468488
56MP0000371_diluted_coat_color1.39246689
57MP0003941_abnormal_skin_development1.35966885
58MP0000015_abnormal_ear_pigmentation1.35794925
59MP0005380_embryogenesis_phenotype1.34473231
60MP0001672_abnormal_embryogenesis/_devel1.34473231
61MP0001929_abnormal_gametogenesis1.32570365
62MP0005058_abnormal_lysosome_morphology1.30957837
63MP0000372_irregular_coat_pigmentation1.30327547
64MP0002269_muscular_atrophy1.29073831
65MP0000470_abnormal_stomach_morphology1.28414276
66MP0000462_abnormal_digestive_system1.25267119
67MP0001764_abnormal_homeostasis1.24745705
68MP0000350_abnormal_cell_proliferation1.22873988
69MP0003718_maternal_effect1.22849976
70MP0002751_abnormal_autonomic_nervous1.20416608
71MP0001730_embryonic_growth_arrest1.19933921
72MP0000639_abnormal_adrenal_gland1.18189311
73MP0000653_abnormal_sex_gland1.16969518
74MP0002736_abnormal_nociception_after1.16641958
75MP0003937_abnormal_limbs/digits/tail_de1.15680665
76MP0005499_abnormal_olfactory_system1.13263983
77MP0005394_taste/olfaction_phenotype1.13263983
78MP0002111_abnormal_tail_morphology1.13115420
79MP0002796_impaired_skin_barrier1.12919331
80MP0005085_abnormal_gallbladder_physiolo1.12211123
81MP0004264_abnormal_extraembryonic_tissu1.08968486
82MP0002019_abnormal_tumor_incidence1.06745013
83MP0001340_abnormal_eyelid_morphology1.06481309
84MP0002080_prenatal_lethality1.05408111
85MP0003828_pulmonary_edema1.02225826
86MP0003984_embryonic_growth_retardation1.02141811
87MP0002396_abnormal_hematopoietic_system1.01601063
88MP0002102_abnormal_ear_morphology1.00219639
89MP0005365_abnormal_bile_salt0.99260527
90MP0005266_abnormal_metabolism0.98440004
91MP0002160_abnormal_reproductive_system0.97457064
92MP0002088_abnormal_embryonic_growth/wei0.97419330
93MP0000631_abnormal_neuroendocrine_gland0.95992461
94MP0002932_abnormal_joint_morphology0.94362323
95MP0002075_abnormal_coat/hair_pigmentati0.92925376
96MP0000762_abnormal_tongue_morphology0.92356800
97MP0000566_synostosis0.90650946
98MP0003755_abnormal_palate_morphology0.89034574
99MP0003880_abnormal_central_pattern0.88728216
100MP0001661_extended_life_span0.88292364
101MP0005646_abnormal_pituitary_gland0.87715771
102MP0002233_abnormal_nose_morphology0.87423202
103MP0003315_abnormal_perineum_morphology0.87325179
104MP0003698_abnormal_male_reproductive0.87300648
105MP0002697_abnormal_eye_size0.85820230
106MP0000049_abnormal_middle_ear0.85399637
107MP0000647_abnormal_sebaceous_gland0.85303482
108MP0001286_abnormal_eye_development0.84075292
109MP0002114_abnormal_axial_skeleton0.83363050
110MP0003935_abnormal_craniofacial_develop0.82831242
111MP0010307_abnormal_tumor_latency0.81940717
112MP0001119_abnormal_female_reproductive0.81585127
113MP0009115_abnormal_fat_cell0.80927263
114MP0001346_abnormal_lacrimal_gland0.80866950
115MP0001186_pigmentation_phenotype0.80674750
116MP0001145_abnormal_male_reproductive0.80439243
117MP0000313_abnormal_cell_death0.80199976
118MP0002060_abnormal_skin_morphology0.79409791
119MP0003137_abnormal_impulse_conducting0.78549536
120MP0009333_abnormal_splenocyte_physiolog0.77996507
121MP0005501_abnormal_skin_physiology0.77728410
122MP0003656_abnormal_erythrocyte_physiolo0.77354900
123MP0002095_abnormal_skin_pigmentation0.76416641
124MP0002161_abnormal_fertility/fecundity0.75532434
125MP0001324_abnormal_eye_pigmentation0.75119507
126MP0005645_abnormal_hypothalamus_physiol0.74605426
127MP0003045_fibrosis0.74382682
128MP0000685_abnormal_immune_system0.73696240
129MP0005395_other_phenotype0.72818695
130MP0001905_abnormal_dopamine_level0.72692949
131MP0002116_abnormal_craniofacial_bone0.72137146
132MP0004147_increased_porphyrin_level0.71682309
133MP0000537_abnormal_urethra_morphology0.70745658
134MP0002332_abnormal_exercise_endurance0.70251910
135MP0005408_hypopigmentation0.69996605
136MP0000432_abnormal_head_morphology0.69107165
137MP0005389_reproductive_system_phenotype0.68273541
138MP0002405_respiratory_system_inflammati0.67908308
139* MP0008058_abnormal_DNA_repair0.67881826
140MP0005330_cardiomyopathy0.67867014
141MP0009053_abnormal_anal_canal0.64634120
142MP0000467_abnormal_esophagus_morphology0.64613779
143MP0008872_abnormal_physiological_respon0.64316128
144MP0003699_abnormal_female_reproductive0.63333660
145MP0005391_vision/eye_phenotype0.63268371
146MP0005367_renal/urinary_system_phenotyp0.63158816
147MP0000516_abnormal_urinary_system0.63158816
148MP0004019_abnormal_vitamin_homeostasis0.62472628
149MP0003806_abnormal_nucleotide_metabolis0.62303547
150MP0004142_abnormal_muscle_tone0.61964145
151MP0006082_CNS_inflammation0.61465161
152MP0005508_abnormal_skeleton_morphology0.61300244
153MP0001727_abnormal_embryo_implantation0.61189500
154MP0005253_abnormal_eye_physiology0.59413265
155MP0009250_abnormal_appendicular_skeleto0.58845557
156MP0003221_abnormal_cardiomyocyte_apopto0.58280239

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.67470988
2Concave nail (HP:0001598)5.24840737
3Facial hemangioma (HP:0000329)5.18180911
4Pustule (HP:0200039)5.16871997
5Annular pancreas (HP:0001734)5.09921879
6Rectal fistula (HP:0100590)5.04965433
7Rectovaginal fistula (HP:0000143)5.04965433
8Increased IgM level (HP:0003496)4.63640103
9Poikiloderma (HP:0001029)4.62220104
10Intestinal fistula (HP:0100819)4.53665964
11Vaginal fistula (HP:0004320)4.49744350
12Hypochromic microcytic anemia (HP:0004840)4.48206420
13Alopecia of scalp (HP:0002293)4.46774638
14Turricephaly (HP:0000262)4.42656240
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.32460095
16Acute necrotizing encephalopathy (HP:0006965)4.27505948
17Abnormal number of erythroid precursors (HP:0012131)4.18696032
18Mitochondrial inheritance (HP:0001427)4.11975964
19Ulnar bowing (HP:0003031)4.10566880
20Increased CSF lactate (HP:0002490)4.10084600
21Acute encephalopathy (HP:0006846)4.08854685
22Abnormal mitochondria in muscle tissue (HP:0008316)4.06479859
23Tongue fasciculations (HP:0001308)4.06224352
24Abnormality of cells of the erythroid lineage (HP:0012130)4.05103581
25Hepatocellular necrosis (HP:0001404)3.97944720
26Microvesicular hepatic steatosis (HP:0001414)3.93031755
27Male infertility (HP:0003251)3.85415066
28Short humerus (HP:0005792)3.82897791
29Abnormal hemoglobin (HP:0011902)3.78132031
30Aplasia/hypoplasia of the humerus (HP:0006507)3.77958888
31Coronal craniosynostosis (HP:0004440)3.74014899
32Muscle fibrillation (HP:0010546)3.72941931
33Increased hepatocellular lipid droplets (HP:0006565)3.69900575
34Hepatic necrosis (HP:0002605)3.67841717
35Orthostatic hypotension (HP:0001278)3.64001155
36Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61850965
37Reticulocytopenia (HP:0001896)3.59284918
38Intestinal atresia (HP:0011100)3.57645586
39Absent radius (HP:0003974)3.50355592
40Progressive macrocephaly (HP:0004481)3.49088696
41Lipid accumulation in hepatocytes (HP:0006561)3.42351389
42Chromsome breakage (HP:0040012)3.41677387
43Cerebral edema (HP:0002181)3.36612906
44Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.34133613
45Vertebral hypoplasia (HP:0008417)3.34133613
46Anteriorly placed anus (HP:0001545)3.30442961
47Aplasia involving forearm bones (HP:0009822)3.29184587
48Absent forearm bone (HP:0003953)3.29184587
49Increased serum lactate (HP:0002151)3.28224189
50Abnormality of male internal genitalia (HP:0000022)3.26876653
51Squamous cell carcinoma (HP:0002860)3.16883848
52Dysautonomia (HP:0002459)3.16476836
53Alacrima (HP:0000522)3.16272548
54Type I transferrin isoform profile (HP:0003642)3.16080758
55Absent thumb (HP:0009777)3.13557549
56Short chin (HP:0000331)3.11640247
57Congenital hip dislocation (HP:0001374)3.05039191
58Urinary glycosaminoglycan excretion (HP:0003541)3.04036496
59Mucopolysacchariduria (HP:0008155)3.04036496
60Macrocytic anemia (HP:0001972)3.03685285
61Abnormality of the aortic arch (HP:0012303)3.02087898
62Broad alveolar ridges (HP:0000187)3.00719981
63Lactic acidosis (HP:0003128)2.99460152
64Patellar aplasia (HP:0006443)2.90578103
65Basal cell carcinoma (HP:0002671)2.90034790
66Meckel diverticulum (HP:0002245)2.87437954
67Albinism (HP:0001022)2.87006407
68Increased intramyocellular lipid droplets (HP:0012240)2.86399585
69Premature skin wrinkling (HP:0100678)2.85551983
70Abnormal protein glycosylation (HP:0012346)2.85269732
71Abnormal glycosylation (HP:0012345)2.85269732
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85269732
73Abnormal protein N-linked glycosylation (HP:0012347)2.85269732
74Large for gestational age (HP:0001520)2.83012816
75Diaphragmatic weakness (HP:0009113)2.78926749
76Abnormality of the preputium (HP:0100587)2.77640572
77Abnormality of the ileum (HP:0001549)2.75461518
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.75022725
79Pancreatic islet-cell hyperplasia (HP:0004510)2.74615617
80Hypotrichosis (HP:0001006)2.73452445
81Premature graying of hair (HP:0002216)2.73372179
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72622685
83Abnormality of polysaccharide metabolism (HP:0011012)2.72622685
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72622685
85Renal Fanconi syndrome (HP:0001994)2.72449048
86Dysostosis multiplex (HP:0000943)2.70502442
87Selective tooth agenesis (HP:0001592)2.67143780
88Aplasia/Hypoplasia of the patella (HP:0006498)2.66469224
89Capillary hemangiomas (HP:0005306)2.64013208
90Exercise intolerance (HP:0003546)2.62867111
91Abnormality of glycolysis (HP:0004366)2.62667828
92Volvulus (HP:0002580)2.61972707
93Joint stiffness (HP:0001387)2.58076148
94Choanal stenosis (HP:0000452)2.57118590
95Bifid uvula (HP:0000193)2.57072686
96Growth hormone excess (HP:0000845)2.55837944
97Increased serum pyruvate (HP:0003542)2.55367442
98Birth length less than 3rd percentile (HP:0003561)2.55099780
99Hamartoma (HP:0010566)2.53707366
100Hypochromic anemia (HP:0001931)2.53562804
101Polycythemia (HP:0001901)2.52375332
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51226422
103Hypokinesia (HP:0002375)2.50557206
104Aplasia of the musculature (HP:0100854)2.48152692
105Colon cancer (HP:0003003)2.46020179
106Abnormality of the labia minora (HP:0012880)2.45430018
107Clumsiness (HP:0002312)2.43013981
108Acute lymphatic leukemia (HP:0006721)2.42217353
109Hypotelorism (HP:0000601)2.41003922
110Decreased lacrimation (HP:0000633)2.36281860
111Increased muscle lipid content (HP:0009058)2.34068925
112Respiratory failure (HP:0002878)2.29639176
113IgA deficiency (HP:0002720)2.29164229
114Bowing of the arm (HP:0006488)2.28958124
115Bowed forearm bones (HP:0003956)2.28958124
116Vertebral fusion (HP:0002948)2.28384276
117Increased number of teeth (HP:0011069)2.26412659
118Abnormality of chromosome stability (HP:0003220)2.26339128
119Lethargy (HP:0001254)2.25628339
120Degeneration of anterior horn cells (HP:0002398)2.22501583
121Abnormality of the anterior horn cell (HP:0006802)2.22501583
122Hypoplasia of the radius (HP:0002984)2.21740765
123Cerebral aneurysm (HP:0004944)2.20106146
124Popliteal pterygium (HP:0009756)2.19049782
125Pancytopenia (HP:0001876)2.18382023
126Reduced antithrombin III activity (HP:0001976)2.17728060
127Split hand (HP:0001171)2.16890190
128Amelogenesis imperfecta (HP:0000705)2.13814843
129Leukodystrophy (HP:0002415)2.13313582
130Testicular atrophy (HP:0000029)2.12949805
1313-Methylglutaconic aciduria (HP:0003535)2.12947321
132Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12849569
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12849569
134Small intestinal stenosis (HP:0012848)2.12083801
135Duodenal stenosis (HP:0100867)2.12083801
136Astrocytoma (HP:0009592)2.11359181
137Abnormality of the astrocytes (HP:0100707)2.11359181
138Triphalangeal thumb (HP:0001199)2.10819609
139Gastrointestinal atresia (HP:0002589)2.10241592
140Optic disc pallor (HP:0000543)2.08140667
141Muscle fiber atrophy (HP:0100295)2.07815672
142Narrow nasal bridge (HP:0000446)2.07076788
143Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06868111
144Abnormality of methionine metabolism (HP:0010901)2.06759945
145Pallor (HP:0000980)2.06321875
146Hypoplastic pelvis (HP:0008839)2.05034952
147Redundant skin (HP:0001582)2.04629157
148Aplastic anemia (HP:0001915)2.03925524
149Hyperglycinemia (HP:0002154)2.03563653
150Bulbar palsy (HP:0001283)2.01142160
151Hyperglycinuria (HP:0003108)2.00289326
152Hypoplasia of the ulna (HP:0003022)1.99800898
153Progressive muscle weakness (HP:0003323)1.97552937
154Neoplasm of the oral cavity (HP:0100649)1.96784707
155Abnormality of the carotid arteries (HP:0005344)1.96012245
156Lower limb hyperreflexia (HP:0002395)1.94516483
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94437179
158CNS demyelination (HP:0007305)1.94321447
159Median cleft lip (HP:0000161)1.93594085
160Type 2 muscle fiber atrophy (HP:0003554)1.92865263
161Spinal muscular atrophy (HP:0007269)1.92414843
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92355377
163Hypoplasia of the pons (HP:0012110)1.92210620
164Horseshoe kidney (HP:0000085)1.92173767
165Short 5th finger (HP:0009237)1.91521392
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91437090
167Exertional dyspnea (HP:0002875)1.91315147
168Cheilitis (HP:0100825)1.90690159
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88731555
170Abnormality of alanine metabolism (HP:0010916)1.88731555
171Hyperalaninemia (HP:0003348)1.88731555
172CNS hypomyelination (HP:0003429)1.85406225
173Progressive microcephaly (HP:0000253)1.84371331
174Cerebral hypomyelination (HP:0006808)1.84329804
175Abnormality of the duodenum (HP:0002246)1.83342253
176Sclerocornea (HP:0000647)1.83033878
177Dicarboxylic aciduria (HP:0003215)1.82811742
178Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82811742
179Myelodysplasia (HP:0002863)1.82610642
180Respiratory difficulties (HP:0002880)1.82517806
181Methylmalonic acidemia (HP:0002912)1.82046424
182Cerebellar dysplasia (HP:0007033)1.81525799
183Abnormality of serum amino acid levels (HP:0003112)1.81339057
184Medial flaring of the eyebrow (HP:0010747)1.78318137
185Cleft eyelid (HP:0000625)1.77590855
186Methylmalonic aciduria (HP:0012120)1.77060968
187Spastic paraparesis (HP:0002313)1.76735551
188Opisthotonus (HP:0002179)1.76172133
189Multiple enchondromatosis (HP:0005701)1.76048699
190Abnormality of the pons (HP:0007361)1.75818931
191Emotional lability (HP:0000712)1.73307248
192Pancreatic cysts (HP:0001737)1.73243360
193Abnormality of serine family amino acid metabolism (HP:0010894)1.71681772
194Abnormality of glycine metabolism (HP:0010895)1.71681772
195High anterior hairline (HP:0009890)1.71316362
196Ependymoma (HP:0002888)1.68920733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.94997537
2DDR25.04652027
3MAPK154.99065901
4MAP3K64.83476762
5VRK24.78394888
6MAP3K113.62179137
7PBK3.55596751
8SRPK13.44144065
9PINK13.33947704
10ZAK3.16219513
11MATK3.09850749
12NME22.98174281
13TYRO32.98147127
14VRK12.95258675
15FGR2.90495546
16DAPK12.56955232
17EIF2AK12.51666103
18PIM22.44368262
19NUAK12.39665492
20PRKD22.27648679
21UHMK12.24481164
22BMX2.15507240
23YES12.13549082
24CSK2.10075470
25STK162.07462504
26TSSK61.99367544
27PDGFRA1.93101180
28DYRK1B1.91825039
29CDK71.88672289
30EIF2AK31.78812663
31NME11.74028730
32TLK11.72594430
33AKT31.72546443
34PLK31.71587727
35LATS21.58892522
36TRPM71.56648025
37PLK41.55259549
38TAF11.55254668
39PIM11.42886112
40CCNB11.38094074
41CDK61.37627801
42BRSK21.36237319
43MST41.28306118
44MKNK11.25092125
45BRSK11.24222836
46RPS6KC11.20679713
47RPS6KL11.20679713
48CDC42BPA1.18454655
49SCYL21.18022950
50PDK21.16484033
51CHEK21.15778875
52MAP4K21.12624846
53MAPK111.10602706
54DYRK31.06186437
55MAP2K71.05720050
56RPS6KA61.04310005
57GSK3A1.03982678
58PHKG21.03365522
59PHKG11.03365522
60PLK10.99523064
61EIF2AK20.94562282
62PASK0.92894280
63WNK40.86739393
64TRIM280.86424909
65PRPF4B0.85765895
66TESK20.84263693
67RPS6KA50.82164919
68STK40.82048240
69TAOK20.81277941
70WNK30.81273006
71TESK10.79788625
72CSNK1G30.79595226
73PNCK0.78977309
74STK390.75309284
75MAP3K100.73370879
76WEE10.70480451
77MTOR0.68621565
78RPS6KB20.68478488
79EPHA20.67183973
80RAF10.67146186
81HIPK20.67133177
82RPS6KA40.66861530
83RPS6KA10.65472991
84PRKAA10.64871143
85KDR0.63225063
86ATR0.62254777
87SMG10.61749188
88CLK10.61469636
89LRRK20.61454356
90BUB10.59524649
91MKNK20.59272132
92CDK90.58394054
93NEK20.55995221
94CSNK1A1L0.55866534
95MAPKAPK50.54741159
96CDK120.54492557
97ILK0.54377647
98CDK30.52798379
99INSRR0.52580336
100CDK20.51308919
101MAP3K40.49506884
102ERBB30.48748818
103CSNK2A10.48386414
104LIMK10.47812346
105AURKA0.47321315
106ABL20.46761185
107DYRK20.46410148
108DAPK30.46304161
109ARAF0.45707542
110CDC70.45215506
111AKT20.44658552
112EGFR0.44311168
113RPS6KB10.40697605
114OXSR10.40340546
115ERBB40.40277280
116LYN0.39035146
117MAP3K80.38883045
118CSNK1G10.38194514
119CSNK1G20.38180912
120CAMK2G0.38008391
121TAOK10.37311418
122MAP3K90.37298353
123NEK10.35122551
124CHEK10.34785434
125MAPK30.34770717
126CAMK2B0.34661154
127CSNK2A20.34437044
128MAPKAPK30.34298681
129STK30.33912642
130MAPK10.33726197
131MUSK0.32275099
132AURKB0.31655357
133ATM0.31501721
134CSNK1E0.30160144
135MAPK40.30035606
136BMPR1B0.29421789
137MAPK100.28941312
138PAK40.28750150
139LATS10.28396862
140PRKAA20.28047554
141CDK40.28015494
142MAPK140.27776380
143PDGFRB0.26525866
144BRAF0.25885230
145TGFBR10.25360898
146TNIK0.25310660
147CDK10.24777974
148PRKDC0.24224410
149ALK0.23915408
150TTK0.23415020
151TRIB30.23007890
152CDK80.22227909
153PRKCI0.21888067
154MAPKAPK20.21599554
155TNK20.21339449
156STK38L0.20843355
157FLT30.19534133
158PTK20.19352905
159INSR0.19001950
160BCKDK0.17531595
161STK380.17109373
162PAK10.16421953
163PRKCZ0.15928998
164CAMK2D0.15193150
165CAMK2A0.14366235
166PAK20.13484367
167GSK3B0.13416448

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.25734286
2Fatty acid biosynthesis_Homo sapiens_hsa000615.20935850
3Base excision repair_Homo sapiens_hsa034104.82116390
4DNA replication_Homo sapiens_hsa030304.21299093
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62688395
6Oxidative phosphorylation_Homo sapiens_hsa001902.58509312
7Nucleotide excision repair_Homo sapiens_hsa034202.52636449
8Parkinsons disease_Homo sapiens_hsa050122.35059310
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33989363
10Spliceosome_Homo sapiens_hsa030402.25419376
11RNA transport_Homo sapiens_hsa030132.24975451
12Homologous recombination_Homo sapiens_hsa034402.11579532
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07545423
14Non-homologous end-joining_Homo sapiens_hsa034502.01901117
15mRNA surveillance pathway_Homo sapiens_hsa030151.98705209
16Circadian rhythm_Homo sapiens_hsa047101.96522255
17Arginine and proline metabolism_Homo sapiens_hsa003301.94048110
18mTOR signaling pathway_Homo sapiens_hsa041501.88178285
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88036078
20Fanconi anemia pathway_Homo sapiens_hsa034601.85505630
21Huntingtons disease_Homo sapiens_hsa050161.80496850
22Notch signaling pathway_Homo sapiens_hsa043301.78030799
23Caffeine metabolism_Homo sapiens_hsa002321.77822244
24Protein export_Homo sapiens_hsa030601.77093518
25Hippo signaling pathway_Homo sapiens_hsa043901.75193804
26p53 signaling pathway_Homo sapiens_hsa041151.74932106
27Hedgehog signaling pathway_Homo sapiens_hsa043401.74678870
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71466610
29Folate biosynthesis_Homo sapiens_hsa007901.69309641
30Biosynthesis of amino acids_Homo sapiens_hsa012301.64719195
31Sulfur relay system_Homo sapiens_hsa041221.64126232
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56994418
33Cell cycle_Homo sapiens_hsa041101.55871443
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55205829
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51641510
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47096248
37Adherens junction_Homo sapiens_hsa045201.45703074
38Ribosome_Homo sapiens_hsa030101.38619354
39Purine metabolism_Homo sapiens_hsa002301.37203798
40Alzheimers disease_Homo sapiens_hsa050101.35625205
41Pyruvate metabolism_Homo sapiens_hsa006201.33522315
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29212123
43Fatty acid metabolism_Homo sapiens_hsa012121.27001962
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26664848
45TGF-beta signaling pathway_Homo sapiens_hsa043501.25178169
46Propanoate metabolism_Homo sapiens_hsa006401.24580944
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22047425
48Bladder cancer_Homo sapiens_hsa052191.21918422
49Carbon metabolism_Homo sapiens_hsa012001.20392921
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18819033
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16924358
52Shigellosis_Homo sapiens_hsa051311.10749496
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10019254
54Fructose and mannose metabolism_Homo sapiens_hsa000511.09114492
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.06443318
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06336837
57Wnt signaling pathway_Homo sapiens_hsa043101.02801112
58Lysine degradation_Homo sapiens_hsa003100.99126264
59Basal cell carcinoma_Homo sapiens_hsa052170.97748016
60Oocyte meiosis_Homo sapiens_hsa041140.96437018
61RNA polymerase_Homo sapiens_hsa030200.91113768
62One carbon pool by folate_Homo sapiens_hsa006700.88049781
63Peroxisome_Homo sapiens_hsa041460.83967241
64Vitamin B6 metabolism_Homo sapiens_hsa007500.83222017
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82896793
66VEGF signaling pathway_Homo sapiens_hsa043700.81677409
67Arginine biosynthesis_Homo sapiens_hsa002200.79312491
68Pentose phosphate pathway_Homo sapiens_hsa000300.78577495
69Proteasome_Homo sapiens_hsa030500.78193686
70N-Glycan biosynthesis_Homo sapiens_hsa005100.75039980
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.74801668
72Colorectal cancer_Homo sapiens_hsa052100.74551752
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74079565
74Primary immunodeficiency_Homo sapiens_hsa053400.73686874
75Butanoate metabolism_Homo sapiens_hsa006500.70250151
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.70083353
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67109796
78Cardiac muscle contraction_Homo sapiens_hsa042600.66968463
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66658886
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65069377
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64996793
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63242750
83Pyrimidine metabolism_Homo sapiens_hsa002400.62898430
84MicroRNAs in cancer_Homo sapiens_hsa052060.62846471
85Galactose metabolism_Homo sapiens_hsa000520.62355332
86Glutathione metabolism_Homo sapiens_hsa004800.62014409
87RNA degradation_Homo sapiens_hsa030180.61810928
88Tryptophan metabolism_Homo sapiens_hsa003800.56522907
89Tight junction_Homo sapiens_hsa045300.56450811
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55330217
91Basal transcription factors_Homo sapiens_hsa030220.54472989
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.53091771
93Systemic lupus erythematosus_Homo sapiens_hsa053220.51223842
94Thyroid cancer_Homo sapiens_hsa052160.50113062
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48170142
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47503481
97Acute myeloid leukemia_Homo sapiens_hsa052210.47136401
98Choline metabolism in cancer_Homo sapiens_hsa052310.46626608
99Legionellosis_Homo sapiens_hsa051340.46288955
100AMPK signaling pathway_Homo sapiens_hsa041520.44497479
101Viral carcinogenesis_Homo sapiens_hsa052030.44159678
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42989839
103Small cell lung cancer_Homo sapiens_hsa052220.42900190
104Chronic myeloid leukemia_Homo sapiens_hsa052200.42043433
105ErbB signaling pathway_Homo sapiens_hsa040120.41611517
106Nitrogen metabolism_Homo sapiens_hsa009100.41421047
107Dorso-ventral axis formation_Homo sapiens_hsa043200.40818734
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39009003
109Tyrosine metabolism_Homo sapiens_hsa003500.38273107
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.38225517
111Epstein-Barr virus infection_Homo sapiens_hsa051690.38196370
112Insulin signaling pathway_Homo sapiens_hsa049100.38097057
113Viral myocarditis_Homo sapiens_hsa054160.37735166
114Gap junction_Homo sapiens_hsa045400.37602882
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35902025
116beta-Alanine metabolism_Homo sapiens_hsa004100.34757752
117Fatty acid degradation_Homo sapiens_hsa000710.32971499
118Phenylalanine metabolism_Homo sapiens_hsa003600.32953814
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32425103
120Alcoholism_Homo sapiens_hsa050340.31317192
121Chemical carcinogenesis_Homo sapiens_hsa052040.29689298
122Herpes simplex infection_Homo sapiens_hsa051680.29210717
123Selenocompound metabolism_Homo sapiens_hsa004500.28980326
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28534997
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.25793624
126Steroid biosynthesis_Homo sapiens_hsa001000.24556594
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24524028
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22646789
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20062688
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20032478
131Phototransduction_Homo sapiens_hsa047440.19208572
132HTLV-I infection_Homo sapiens_hsa051660.18956065
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18212527
134Sulfur metabolism_Homo sapiens_hsa009200.18209231
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17246105
136Endometrial cancer_Homo sapiens_hsa052130.16963093
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.16770742
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.16075864
139MAPK signaling pathway_Homo sapiens_hsa040100.14902549
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14152803
141Proteoglycans in cancer_Homo sapiens_hsa052050.13887334
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13288516
143Arachidonic acid metabolism_Homo sapiens_hsa005900.12994220
144Hepatitis B_Homo sapiens_hsa051610.11625588
145Pathways in cancer_Homo sapiens_hsa052000.11618756
146Fatty acid elongation_Homo sapiens_hsa000620.09809273
147Prostate cancer_Homo sapiens_hsa052150.08378929
148Metabolic pathways_Homo sapiens_hsa011000.07941071
149Linoleic acid metabolism_Homo sapiens_hsa005910.07842650
150Regulation of autophagy_Homo sapiens_hsa041400.07269556

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