ALKBH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.04232445
2ribosomal small subunit assembly (GO:0000028)4.51277006
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06937438
4ribosome assembly (GO:0042255)3.95980073
5mitochondrial respiratory chain complex assembly (GO:0033108)3.86262318
6establishment of viral latency (GO:0019043)3.84644810
7maturation of SSU-rRNA (GO:0030490)3.71574682
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65859666
9deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.64762023
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63889862
11ATP synthesis coupled proton transport (GO:0015986)3.63889862
12maturation of 5.8S rRNA (GO:0000460)3.51162741
13respiratory electron transport chain (GO:0022904)3.44101006
14pseudouridine synthesis (GO:0001522)3.39795780
15electron transport chain (GO:0022900)3.36939670
16mannosylation (GO:0097502)3.35142315
17GMP metabolic process (GO:0046037)3.27028084
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25149934
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24725149
20folic acid metabolic process (GO:0046655)3.23600345
21regulation of ubiquitin-protein transferase activity (GO:0051438)3.18544031
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17450277
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17252594
24chaperone-mediated protein transport (GO:0072321)3.15864797
25autophagic vacuole fusion (GO:0000046)3.11802864
26regulation of cellular amine metabolic process (GO:0033238)3.10237388
27protein neddylation (GO:0045116)3.09612080
28regulation of ligase activity (GO:0051340)3.08111361
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07217688
30protein targeting to mitochondrion (GO:0006626)3.06371123
31cellular component biogenesis (GO:0044085)3.05815759
32telomere maintenance via semi-conservative replication (GO:0032201)3.05639492
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05105483
34negative regulation of protein ubiquitination (GO:0031397)3.05092472
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.04968181
36formation of translation preinitiation complex (GO:0001731)3.02533980
37IMP biosynthetic process (GO:0006188)3.02079718
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01702120
39viral transcription (GO:0019083)3.01214100
40translational termination (GO:0006415)3.00481066
41ubiquinone metabolic process (GO:0006743)2.99752593
42regulation of cellular amino acid metabolic process (GO:0006521)2.98508674
43proteasome assembly (GO:0043248)2.97541874
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97383020
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97173038
46deoxyribose phosphate biosynthetic process (GO:0046385)2.97034586
472-deoxyribonucleotide biosynthetic process (GO:0009265)2.97034586
48purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.96751512
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96448111
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95851322
51purine-containing compound salvage (GO:0043101)2.95204458
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94689463
53purine nucleobase biosynthetic process (GO:0009113)2.91954657
54cotranslational protein targeting to membrane (GO:0006613)2.91874085
55translational elongation (GO:0006414)2.91194992
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90714528
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90714528
58cytochrome complex assembly (GO:0017004)2.90244546
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89935521
60negative regulation of ligase activity (GO:0051352)2.89935521
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89814772
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89814772
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89814772
64protein targeting to ER (GO:0045047)2.89133706
65negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.87061631
66establishment of integrated proviral latency (GO:0075713)2.85589858
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85146852
68L-methionine salvage (GO:0071267)2.85079220
69L-methionine biosynthetic process (GO:0071265)2.85079220
70amino acid salvage (GO:0043102)2.85079220
71heme biosynthetic process (GO:0006783)2.85018763
72respiratory chain complex IV assembly (GO:0008535)2.84290730
73rRNA methylation (GO:0031167)2.83926744
74mitochondrial DNA replication (GO:0006264)2.83408779
75branched-chain amino acid catabolic process (GO:0009083)2.82932141
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82578982
77protein localization to endoplasmic reticulum (GO:0070972)2.81306105
78DNA catabolic process, exonucleolytic (GO:0000738)2.80346087
79signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79581020
80signal transduction involved in DNA damage checkpoint (GO:0072422)2.79581020
81purine nucleotide salvage (GO:0032261)2.77895922
82deoxyribonucleotide biosynthetic process (GO:0009263)2.77137735
83lipopolysaccharide biosynthetic process (GO:0009103)2.77061894
84signal transduction involved in cell cycle checkpoint (GO:0072395)2.76376724
85establishment of protein localization to mitochondrion (GO:0072655)2.74988626
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74823664
87protein maturation by protein folding (GO:0022417)2.74410137
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74072259
89regulation of translation in response to stress (GO:0043555)2.73966302
90negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.73224431
91DNA strand elongation involved in DNA replication (GO:0006271)2.71946175
92tricarboxylic acid cycle (GO:0006099)2.71205852
93telomere maintenance via recombination (GO:0000722)2.66822420
94daunorubicin metabolic process (GO:0044597)2.66192070
95polyketide metabolic process (GO:0030638)2.66192070
96doxorubicin metabolic process (GO:0044598)2.66192070
97DNA strand elongation (GO:0022616)2.65962536
98ribosomal small subunit biogenesis (GO:0042274)2.64980349
99translation (GO:0006412)2.64971265
100ubiquinone biosynthetic process (GO:0006744)2.63401881
101quinone biosynthetic process (GO:1901663)2.63401881
102regulation of mitochondrial translation (GO:0070129)2.60297807
103GDP-mannose metabolic process (GO:0019673)2.60120541
104antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58924162
105translational initiation (GO:0006413)2.57368340
106NADH metabolic process (GO:0006734)2.56780332
107metallo-sulfur cluster assembly (GO:0031163)2.56203836
108iron-sulfur cluster assembly (GO:0016226)2.56203836
109nucleobase biosynthetic process (GO:0046112)2.55807962
110methionine biosynthetic process (GO:0009086)2.54940282
111ribosomal large subunit biogenesis (GO:0042273)2.54029604
112oxidative phosphorylation (GO:0006119)2.53315000
113AMP metabolic process (GO:0046033)2.51417704
114nucleoside salvage (GO:0043174)2.50114405
115valine metabolic process (GO:0006573)2.49382403
116protein deneddylation (GO:0000338)2.48717179
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47979139
118spliceosomal snRNP assembly (GO:0000387)2.44596271
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43650431
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.43650431
121NADH dehydrogenase complex assembly (GO:0010257)2.43650431
122positive regulation of ligase activity (GO:0051351)2.43522625
123response to interferon-beta (GO:0035456)2.42534759
124viral life cycle (GO:0019058)2.42518799
125cellular metabolic compound salvage (GO:0043094)2.41055892
126purine deoxyribonucleotide catabolic process (GO:0009155)2.39454914
127positive regulation of cell cycle arrest (GO:0071158)2.39033993
128ribonucleoprotein complex biogenesis (GO:0022613)2.38674195
129signal peptide processing (GO:0006465)2.38559700
130aspartate family amino acid biosynthetic process (GO:0009067)2.37366642
131rRNA modification (GO:0000154)2.37236982
132methionine metabolic process (GO:0006555)2.36361371
133transcription elongation from RNA polymerase III promoter (GO:0006385)2.36189569
134termination of RNA polymerase III transcription (GO:0006386)2.36189569
1352-oxoglutarate metabolic process (GO:0006103)2.34589215
136protein complex biogenesis (GO:0070271)2.33461834
137cellular protein complex disassembly (GO:0043624)2.33268947
138nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.33249094
139ribosome biogenesis (GO:0042254)2.32735815
140heart process (GO:0003015)2.32390823
141heart contraction (GO:0060047)2.32390823
142tRNA methylation (GO:0030488)2.31637139
143negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.31561328
144platelet dense granule organization (GO:0060155)2.29403471
145viral mRNA export from host cell nucleus (GO:0046784)2.28487067
146DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.28191838
147cullin deneddylation (GO:0010388)2.27501436
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.27063986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53570253
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19151063
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.17093364
4E2F7_22180533_ChIP-Seq_HELA_Human3.14664958
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09940397
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.92060393
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.87217512
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85433674
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73789745
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.65403697
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63985364
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48637628
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.35993351
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33319544
15* VDR_23849224_ChIP-Seq_CD4+_Human2.32748699
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27072903
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12206027
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.12001915
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09324990
20DCP1A_22483619_ChIP-Seq_HELA_Human2.06757390
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03595844
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98166085
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97020071
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95344661
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93446125
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91780693
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.91413530
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89062817
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87023445
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82783390
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82109239
32XRN2_22483619_ChIP-Seq_HELA_Human1.81754350
33* GABP_19822575_ChIP-Seq_HepG2_Human1.81124031
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77661897
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77527044
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75978752
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74403556
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73706556
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72750301
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71997842
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71169982
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70565958
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68586403
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67580066
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63554850
46ELK1_19687146_ChIP-ChIP_HELA_Human1.61748062
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61502602
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60447092
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58665951
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58057325
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56193973
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51020890
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.48618807
54MYC_18940864_ChIP-ChIP_HL60_Human1.47093150
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46663441
56* SPI1_23547873_ChIP-Seq_NB4_Human1.43384429
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42357663
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36087105
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35318141
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30610499
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30364539
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28194121
63CIITA_25753668_ChIP-Seq_RAJI_Human1.26614117
64TTF2_22483619_ChIP-Seq_HELA_Human1.25364069
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.22610972
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21218256
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19983813
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18482515
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17175575
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16925607
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.15823281
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15558844
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15407870
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15003310
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14453315
76GATA1_22025678_ChIP-Seq_K562_Human1.12328051
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11056328
78TFEB_21752829_ChIP-Seq_HELA_Human1.10699241
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09466792
80SCL_19346495_ChIP-Seq_HPC-7_Human1.08817956
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.08447264
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.07986844
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06965166
84VDR_21846776_ChIP-Seq_THP-1_Human1.05987496
85KDM5A_27292631_Chip-Seq_BREAST_Human1.05892488
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05764118
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.03385233
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03224442
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03037814
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02692290
91MYC_22102868_ChIP-Seq_BL_Human1.02344941
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00346370
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99742014
94AR_21909140_ChIP-Seq_LNCAP_Human0.99585393
95FOXM1_23109430_ChIP-Seq_U2OS_Human0.98736602
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98407982
97MYB_26560356_Chip-Seq_TH2_Human0.98091881
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.98023048
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96638257
100* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96423053
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95994670
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95624082
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94690048
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94662215
105VDR_22108803_ChIP-Seq_LS180_Human0.94114085
106* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92605427
107* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92571554
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92159335
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91919665
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88710741
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87881123
112ELF5_23300383_ChIP-Seq_T47D_Human0.84770016
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84608712
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82138071
115IRF1_19129219_ChIP-ChIP_H3396_Human0.80295156
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77427858
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77202174
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76284520
119PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76260063
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73783975
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73704766
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68534714
123TP53_22573176_ChIP-Seq_HFKS_Human0.66869693
124ZNF274_21170338_ChIP-Seq_K562_Hela0.66661540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.38353455
2MP0003693_abnormal_embryo_hatching2.89289838
3MP0003186_abnormal_redox_activity2.17399033
4MP0002102_abnormal_ear_morphology2.13910898
5MP0003718_maternal_effect2.13559054
6MP0000749_muscle_degeneration2.08802720
7MP0002396_abnormal_hematopoietic_system2.06841821
8MP0006036_abnormal_mitochondrial_physio1.88401597
9MP0004147_increased_porphyrin_level1.88231371
10MP0005084_abnormal_gallbladder_morpholo1.84282094
11MP0008877_abnormal_DNA_methylation1.83451343
12MP0005365_abnormal_bile_salt1.79953297
13MP0009785_altered_susceptibility_to1.78975297
14MP0003724_increased_susceptibility_to1.76416481
15MP0003646_muscle_fatigue1.74380650
16MP0002234_abnormal_pharynx_morphology1.72337320
17MP0004084_abnormal_cardiac_muscle1.68412019
18MP0008260_abnormal_autophagy1.64726675
19MP0003077_abnormal_cell_cycle1.62422764
20MP0009840_abnormal_foam_cell1.59341134
21MP0003656_abnormal_erythrocyte_physiolo1.57504632
22MP0001853_heart_inflammation1.56967084
23MP0005075_abnormal_melanosome_morpholog1.53867185
24MP0003763_abnormal_thymus_physiology1.52320868
25MP0006072_abnormal_retinal_apoptosis1.51856464
26MP0005671_abnormal_response_to1.50941495
27MP0008875_abnormal_xenobiotic_pharmacok1.49591673
28MP0000358_abnormal_cell_content/1.49470894
29MP0002837_dystrophic_cardiac_calcinosis1.49339943
30MP0001905_abnormal_dopamine_level1.47916852
31MP0000343_altered_response_to1.46522830
32MP0005397_hematopoietic_system_phenotyp1.45416341
33MP0001545_abnormal_hematopoietic_system1.45416341
34MP0008007_abnormal_cellular_replicative1.45361578
35MP0002139_abnormal_hepatobiliary_system1.44342280
36MP0004957_abnormal_blastocyst_morpholog1.43245537
37MP0002138_abnormal_hepatobiliary_system1.43118512
38MP0010094_abnormal_chromosome_stability1.40143563
39MP0003111_abnormal_nucleus_morphology1.39971200
40MP0005083_abnormal_biliary_tract1.37325159
41MP0003828_pulmonary_edema1.37145123
42MP0008995_early_reproductive_senescence1.36766797
43MP0003436_decreased_susceptibility_to1.35862426
44MP0009697_abnormal_copulation1.35454444
45MP0008058_abnormal_DNA_repair1.34820957
46MP0001764_abnormal_homeostasis1.33514111
47MP0000685_abnormal_immune_system1.32676356
48MP0009333_abnormal_splenocyte_physiolog1.32260289
49MP0005389_reproductive_system_phenotype1.32173142
50MP0001835_abnormal_antigen_presentation1.30124730
51MP0005330_cardiomyopathy1.29881709
52MP0005360_urolithiasis1.28996267
53MP0002876_abnormal_thyroid_physiology1.28184680
54MP0005319_abnormal_enzyme/_coenzyme1.27807262
55MP0005085_abnormal_gallbladder_physiolo1.26620584
56MP0006082_CNS_inflammation1.25972946
57MP0005025_abnormal_response_to1.25489016
58MP0005670_abnormal_white_adipose1.23991824
59MP0002160_abnormal_reproductive_system1.22128819
60MP0000750_abnormal_muscle_regeneration1.21713505
61MP0002398_abnormal_bone_marrow1.21391413
62MP0005332_abnormal_amino_acid1.17066883
63MP0008469_abnormal_protein_level1.16729878
64MP0002132_abnormal_respiratory_system1.16444780
65MP0004145_abnormal_muscle_electrophysio1.15961592
66MP0002269_muscular_atrophy1.15817455
67MP0000689_abnormal_spleen_morphology1.15489484
68MP0001929_abnormal_gametogenesis1.14789245
69MP0001529_abnormal_vocalization1.14577226
70MP0001800_abnormal_humoral_immune1.12034950
71MP0000613_abnormal_salivary_gland1.11898345
72MP0000681_abnormal_thyroid_gland1.11696302
73MP0003011_delayed_dark_adaptation1.10504854
74MP0002166_altered_tumor_susceptibility1.10309069
75MP0002933_joint_inflammation1.08993159
76MP0002722_abnormal_immune_system1.08952070
77MP0002006_tumorigenesis1.08207833
78MP0002405_respiratory_system_inflammati1.08181101
79MP0002452_abnormal_antigen_presenting1.07839136
80MP0002723_abnormal_immune_serum1.07103374
81MP0004808_abnormal_hematopoietic_stem1.05681718
82MP0002419_abnormal_innate_immunity1.05669730
83MP0001873_stomach_inflammation1.04921016
84MP0000372_irregular_coat_pigmentation1.04323033
85MP0005464_abnormal_platelet_physiology1.04235818
86MP0002420_abnormal_adaptive_immunity1.04186521
87MP0004036_abnormal_muscle_relaxation1.03972636
88MP0003191_abnormal_cellular_cholesterol1.03742717
89MP0006054_spinal_hemorrhage1.03199912
90MP0000465_gastrointestinal_hemorrhage1.02564843
91MP0008438_abnormal_cutaneous_collagen1.02065946
92MP0001819_abnormal_immune_cell1.02019985
93MP0002429_abnormal_blood_cell1.01577779
94MP0004233_abnormal_muscle_weight1.01318907
95MP0003252_abnormal_bile_duct1.00519944
96MP0001542_abnormal_bone_strength1.00310699
97MP0005023_abnormal_wound_healing1.00070727
98MP0000313_abnormal_cell_death1.00031910
99MP0006292_abnormal_olfactory_placode0.99656760
100MP0000716_abnormal_immune_system0.99383639
101MP0000490_abnormal_crypts_of0.99027382
102MP0005000_abnormal_immune_tolerance0.98867723
103MP0002148_abnormal_hypersensitivity_rea0.98191134
104MP0005408_hypopigmentation0.98004538
105MP0006035_abnormal_mitochondrial_morpho0.97814219
106MP0001243_abnormal_dermal_layer0.97593285
107MP0000609_abnormal_liver_physiology0.97121103
108MP0001145_abnormal_male_reproductive0.96392015
109MP0002019_abnormal_tumor_incidence0.93425356
110MP0003786_premature_aging0.93313496
111MP0004130_abnormal_muscle_cell0.92842033
112MP0008775_abnormal_heart_ventricle0.92412987
113MP0000703_abnormal_thymus_morphology0.92048803
114MP0010630_abnormal_cardiac_muscle0.91865303
115MP0001845_abnormal_inflammatory_respons0.91352230
116MP0005410_abnormal_fertilization0.90683451
117MP0000598_abnormal_liver_morphology0.89884698
118MP0003195_calcinosis0.89872339
119MP0002693_abnormal_pancreas_physiology0.88971183
120MP0002210_abnormal_sex_determination0.88771498
121MP0001533_abnormal_skeleton_physiology0.87419466
122MP0004087_abnormal_muscle_fiber0.87375703
123MP0003221_abnormal_cardiomyocyte_apopto0.87365229
124MP0008932_abnormal_embryonic_tissue0.86987932
125MP0005058_abnormal_lysosome_morphology0.86800148
126MP0009765_abnormal_xenobiotic_induced0.86698305
127MP0000653_abnormal_sex_gland0.86409082
128MP0001666_abnormal_nutrient_absorption0.86093415
129MP0001919_abnormal_reproductive_system0.84923705
130MP0003567_abnormal_fetal_cardiomyocyte0.84071670
131MP0003279_aneurysm0.83874567
132MP0009643_abnormal_urine_homeostasis0.83434883
133MP0001544_abnormal_cardiovascular_syste0.83055723
134MP0005385_cardiovascular_system_phenoty0.83055723
135MP0005220_abnormal_exocrine_pancreas0.82291782
136MP0005584_abnormal_enzyme/coenzyme_acti0.82226739
137MP0002928_abnormal_bile_duct0.79698087
138MP0000350_abnormal_cell_proliferation0.79400693
139MP0005310_abnormal_salivary_gland0.76996221
140MP0005367_renal/urinary_system_phenotyp0.73101425
141MP0000516_abnormal_urinary_system0.73101425

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)3.83168743
2Renal Fanconi syndrome (HP:0001994)3.44295653
3Hepatocellular necrosis (HP:0001404)3.43000582
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.38166514
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.38166514
6Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33039778
7Reticulocytopenia (HP:0001896)3.24611406
8Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20885788
9Dicarboxylic aciduria (HP:0003215)3.20885788
10Rhabdomyolysis (HP:0003201)3.20463877
11Abnormality of fatty-acid metabolism (HP:0004359)3.16633623
12Generalized aminoaciduria (HP:0002909)2.82769253
13Abnormal mitochondria in muscle tissue (HP:0008316)2.80442256
14Ventricular tachycardia (HP:0004756)2.80326894
15Increased muscle lipid content (HP:0009058)2.79834199
16Nausea (HP:0002018)2.75933364
17Mitochondrial inheritance (HP:0001427)2.73201311
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.72983308
19Abnormality of glycolysis (HP:0004366)2.71806068
20Increased serum pyruvate (HP:0003542)2.71806068
21Reduced antithrombin III activity (HP:0001976)2.71653908
22Hypokinesia (HP:0002375)2.71497738
23Abnormal number of erythroid precursors (HP:0012131)2.66802690
24Hypoglycemic coma (HP:0001325)2.65410537
25Increased serum lactate (HP:0002151)2.65091118
26Abnormality of cells of the erythroid lineage (HP:0012130)2.64125074
27Palpitations (HP:0001962)2.61585221
28Testicular atrophy (HP:0000029)2.60482106
29Acute necrotizing encephalopathy (HP:0006965)2.58289729
30Increased CSF lactate (HP:0002490)2.57229493
31Metaphyseal dysplasia (HP:0100255)2.55409259
32Thrombocytosis (HP:0001894)2.53485257
33Lactic acidosis (HP:0003128)2.52397999
34Type I transferrin isoform profile (HP:0003642)2.51717174
35Acute encephalopathy (HP:0006846)2.51507314
36Microvesicular hepatic steatosis (HP:0001414)2.48399335
37Methylmalonic acidemia (HP:0002912)2.47930658
38Ragged-red muscle fibers (HP:0003200)2.46702054
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46442079
40Abnormality of alanine metabolism (HP:0010916)2.46442079
41Hyperalaninemia (HP:0003348)2.46442079
42Optic disc pallor (HP:0000543)2.43067601
43Degeneration of anterior horn cells (HP:0002398)2.41411151
44Abnormality of the anterior horn cell (HP:0006802)2.41411151
45Increased intramyocellular lipid droplets (HP:0012240)2.40263271
46Myoglobinuria (HP:0002913)2.37876035
47IgM deficiency (HP:0002850)2.36021820
48Muscle fiber atrophy (HP:0100295)2.35710111
49Cerebral edema (HP:0002181)2.35530340
50Hyperammonemia (HP:0001987)2.34367457
51Elevated erythrocyte sedimentation rate (HP:0003565)2.32806975
52Petechiae (HP:0000967)2.29202745
53Lipid accumulation in hepatocytes (HP:0006561)2.25817701
54Dry hair (HP:0011359)2.25168576
55Lethargy (HP:0001254)2.25080337
56Posterior subcapsular cataract (HP:0007787)2.24245770
57Prolonged neonatal jaundice (HP:0006579)2.23932696
58Abnormality of serum amino acid levels (HP:0003112)2.22841060
59Proximal tubulopathy (HP:0000114)2.22337568
60Rough bone trabeculation (HP:0100670)2.22252807
61Tubulointerstitial nephritis (HP:0001970)2.22162960
62Exercise intolerance (HP:0003546)2.21381063
63Abnormal protein N-linked glycosylation (HP:0012347)2.21364195
64Abnormal protein glycosylation (HP:0012346)2.21364195
65Abnormal glycosylation (HP:0012345)2.21364195
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21364195
67CNS demyelination (HP:0007305)2.21209663
683-Methylglutaconic aciduria (HP:0003535)2.20228996
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18731705
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18108695
71Exertional dyspnea (HP:0002875)2.17511568
72Type 2 muscle fiber atrophy (HP:0003554)2.17075450
73Multiple enchondromatosis (HP:0005701)2.09614422
74Oral leukoplakia (HP:0002745)2.08116925
75Progressive muscle weakness (HP:0003323)2.08024421
76Methylmalonic aciduria (HP:0012120)2.05928529
77Reduced subcutaneous adipose tissue (HP:0003758)2.04197613
78Paralysis (HP:0003470)2.04066584
79Respiratory difficulties (HP:0002880)2.03569145
80Exercise-induced muscle cramps (HP:0003710)2.02692781
81Macrocytic anemia (HP:0001972)2.02517707
82Abnormality of pyrimidine metabolism (HP:0004353)2.01344236
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00605975
84Nonimmune hydrops fetalis (HP:0001790)1.98618625
85Respiratory failure (HP:0002878)1.97304118
86Abnormality of renal resorption (HP:0011038)1.95904868
87Opisthotonus (HP:0002179)1.94895278
88Dilated cardiomyopathy (HP:0001644)1.94041794
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93536227
90Abnormality of midbrain morphology (HP:0002418)1.93225130
91Molar tooth sign on MRI (HP:0002419)1.93225130
92Muscle fiber inclusion bodies (HP:0100299)1.92315901
93Nemaline bodies (HP:0003798)1.92293586
94Renal cortical cysts (HP:0000803)1.92198695
95Short middle phalanx of the 5th finger (HP:0004220)1.91001960
96Distal arthrogryposis (HP:0005684)1.90487072
97Progressive macrocephaly (HP:0004481)1.90336636
98Abnormality of methionine metabolism (HP:0010901)1.89831450
99Leukodystrophy (HP:0002415)1.89302873
100Lipoatrophy (HP:0100578)1.88929773
101Ketosis (HP:0001946)1.88105377
102Progressive external ophthalmoplegia (HP:0000590)1.87903214
103Aplastic anemia (HP:0001915)1.86924501
104Abnormality of the heme biosynthetic pathway (HP:0010472)1.85852201
105Asymmetric septal hypertrophy (HP:0001670)1.85781852
106Microretrognathia (HP:0000308)1.85548019
107Pancytopenia (HP:0001876)1.85007359
108X-linked dominant inheritance (HP:0001423)1.84919420
109Muscle fiber splitting (HP:0003555)1.84597002
110Increased connective tissue (HP:0009025)1.84071142
111Severe global developmental delay (HP:0011344)1.83906497
112Medial flaring of the eyebrow (HP:0010747)1.83404893
113Severe combined immunodeficiency (HP:0004430)1.81351999
114Increased serum ferritin (HP:0003281)1.80903334
115Pallor (HP:0000980)1.80756023
116Recurrent bronchitis (HP:0002837)1.80293497
117Neutropenia (HP:0001875)1.76708668
118Increased hepatocellular lipid droplets (HP:0006565)1.73853330
119Abnormality of serine family amino acid metabolism (HP:0010894)1.71361463
120Abnormality of glycine metabolism (HP:0010895)1.71361463
121Megaloblastic anemia (HP:0001889)1.71116050
122Ketoacidosis (HP:0001993)1.70769122
123Vertebral compression fractures (HP:0002953)1.70347328
124Secondary amenorrhea (HP:0000869)1.69937053
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69702923
126Elevated hepatic transaminases (HP:0002910)1.68423301
127Emotional lability (HP:0000712)1.68239080
128Hyperbilirubinemia (HP:0002904)1.67820815
129Poor head control (HP:0002421)1.67410287
130Vomiting (HP:0002013)1.66483336
131Neoplasm of the adrenal gland (HP:0100631)1.66049836
132Ureteral duplication (HP:0000073)1.65903958
133Hypergonadotropic hypogonadism (HP:0000815)1.65271682
134Metabolic acidosis (HP:0001942)1.65071202
135Abnormality of B cell number (HP:0010975)1.63729184
136B lymphocytopenia (HP:0010976)1.63357502
137Hypoalphalipoproteinemia (HP:0003233)1.62917600
138IgG deficiency (HP:0004315)1.62870866
139Areflexia of lower limbs (HP:0002522)1.62650633
140Entropion (HP:0000621)1.61114446
141Gonadal dysgenesis (HP:0000133)1.60366431
142Median cleft lip (HP:0000161)1.59227238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.92812408
2BUB13.90130191
3MST43.60038548
4NME23.24079673
5STK163.06950786
6EIF2AK12.47931584
7BCKDK2.47583628
8PIM22.22794990
9TESK12.18985855
10SRPK12.17039077
11TESK22.15985171
12MAP4K22.15049699
13MAP4K12.14163472
14KDR2.08790073
15PBK2.04112506
16ZAP701.98401272
17WEE11.88018632
18PDK31.83058271
19PDK41.83058271
20MAP2K31.82230832
21RPS6KA41.80971428
22ZAK1.66390869
23BRSK21.65512209
24TLK11.64304897
25ERN11.64232008
26EIF2AK31.64155851
27MAP3K121.54417146
28ARAF1.47490171
29TBK11.46977178
30TAF11.41962527
31IRAK41.36236732
32TTN1.35338637
33ACVR1B1.34160808
34TAOK31.32594756
35TRIB31.30407870
36CDC71.30377428
37ERBB31.29878937
38OBSCN1.28450969
39TEC1.26324685
40MYLK1.23310643
41TGFBR11.23241407
42NLK1.21715114
43CSNK1G11.20725874
44MAP3K31.20310100
45BTK1.17114610
46TXK1.14260439
47KIT1.13515167
48IKBKE1.13467827
49PLK41.12837796
50LIMK11.11377010
51CDK191.11351271
52NEK91.10861550
53PIK3CG1.09261100
54MAPK151.09161949
55TRIM281.07644661
56MAP3K111.04947687
57MAPKAPK51.04613686
58LRRK21.02001794
59MAP3K51.01645473
60STK390.99484564
61VRK10.99448065
62BLK0.96167302
63DAPK10.95661798
64JAK30.95242856
65PIM10.93766233
66FLT30.93101212
67ILK0.89310742
68RPS6KA50.89190017
69MAPKAPK30.88536862
70PDK20.88254078
71IRAK30.87151294
72EPHA20.86397789
73DYRK30.85563644
74CSF1R0.85011525
75CLK10.83586648
76PASK0.83500961
77MUSK0.83215067
78PKN20.82160646
79STK100.81087000
80TYK20.80835756
81PLK30.80370024
82CDK30.79329384
83AURKB0.77446348
84TIE10.75093169
85CSNK1G30.74919706
86NEK20.73877197
87PINK10.71578761
88TGFBR20.71329568
89PRKG20.70638212
90BRAF0.70628422
91IRAK10.70208085
92IKBKB0.69319264
93RPS6KB20.67680723
94PIK3CA0.66844616
95PHKG20.66065065
96PHKG10.66065065
97SYK0.65727710
98PRKCI0.65603232
99SCYL20.64586341
100NME10.64222554
101CDK80.63675506
102AURKA0.61789822
103NUAK10.60610552
104CDK70.59987994
105NEK10.59713945
106MAP2K70.59434530
107PAK10.59200776
108FGFR40.57412007
109ATR0.57373889
110MAP2K60.53902676
111DAPK30.53623394
112PLK10.53413712
113GRK10.53158819
114OXSR10.52498707
115LYN0.51568442
116STK40.50621102
117MARK30.49571562
118CHEK20.49204526
119MST1R0.48332867
120MAP3K140.46301504
121BRD40.46217071
122CSNK2A10.44872553
123BRSK10.44762887
124LCK0.43893385
125ADRBK20.43777328
126STK240.43675109
127CAMKK20.43272552
128PAK40.42877252
129PLK20.42605360
130TTK0.39999113
131CDK40.39257996
132EIF2AK20.38935703
133ITK0.38840764
134CCNB10.37894037
135ABL20.37863930
136MAP3K80.37856862
137MKNK10.37856306
138CSNK2A20.36825504
139MELK0.36732246
140ATM0.36424191
141MAPK110.34385237
142BMPR1B0.33824946
143TRPM70.33720793
144CAMK2G0.33504178
145CSNK1A1L0.29698951

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.41641182
2Ribosome_Homo sapiens_hsa030102.80672281
3DNA replication_Homo sapiens_hsa030302.70679771
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44966437
5Protein export_Homo sapiens_hsa030602.09282987
6RNA polymerase_Homo sapiens_hsa030202.06123819
7Mismatch repair_Homo sapiens_hsa034301.97896291
8Base excision repair_Homo sapiens_hsa034101.97335019
9Pyrimidine metabolism_Homo sapiens_hsa002401.95278376
10Propanoate metabolism_Homo sapiens_hsa006401.76662095
11Folate biosynthesis_Homo sapiens_hsa007901.73522601
12Fatty acid degradation_Homo sapiens_hsa000711.65441412
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65026519
14Pentose phosphate pathway_Homo sapiens_hsa000301.61068246
15Carbon metabolism_Homo sapiens_hsa012001.58929208
16Nucleotide excision repair_Homo sapiens_hsa034201.53749605
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52134567
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52001364
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51245079
20Homologous recombination_Homo sapiens_hsa034401.49661651
21Selenocompound metabolism_Homo sapiens_hsa004501.46596859
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45245169
23Parkinsons disease_Homo sapiens_hsa050121.43957113
24Pyruvate metabolism_Homo sapiens_hsa006201.43626473
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42542149
26Spliceosome_Homo sapiens_hsa030401.40115286
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36925552
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36912921
29RNA transport_Homo sapiens_hsa030131.36612565
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36377770
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29929705
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29605453
33Oxidative phosphorylation_Homo sapiens_hsa001901.29411129
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26774319
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22082150
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.20642149
37Peroxisome_Homo sapiens_hsa041461.19397775
38Vitamin B6 metabolism_Homo sapiens_hsa007501.16500093
39Fructose and mannose metabolism_Homo sapiens_hsa000511.16287674
40Biosynthesis of amino acids_Homo sapiens_hsa012301.09594370
41Sulfur metabolism_Homo sapiens_hsa009201.08554078
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08197944
43Caffeine metabolism_Homo sapiens_hsa002321.08098377
44Purine metabolism_Homo sapiens_hsa002301.06400915
45Fatty acid metabolism_Homo sapiens_hsa012121.06125534
46One carbon pool by folate_Homo sapiens_hsa006701.04660303
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03234052
48Sulfur relay system_Homo sapiens_hsa041221.01297422
49Primary immunodeficiency_Homo sapiens_hsa053400.98904013
50Galactose metabolism_Homo sapiens_hsa000520.98742611
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.98234204
52RNA degradation_Homo sapiens_hsa030180.97916037
53Huntingtons disease_Homo sapiens_hsa050160.95951652
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93370129
55Glutathione metabolism_Homo sapiens_hsa004800.92193608
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90248482
57Asthma_Homo sapiens_hsa053100.89339009
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.87908665
59Basal transcription factors_Homo sapiens_hsa030220.86613164
60beta-Alanine metabolism_Homo sapiens_hsa004100.85698391
61Fatty acid elongation_Homo sapiens_hsa000620.84256622
62Non-homologous end-joining_Homo sapiens_hsa034500.83796086
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80530846
64Cell cycle_Homo sapiens_hsa041100.78442061
65Legionellosis_Homo sapiens_hsa051340.76328080
66Fanconi anemia pathway_Homo sapiens_hsa034600.75745091
67Starch and sucrose metabolism_Homo sapiens_hsa005000.74794153
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72293160
69PPAR signaling pathway_Homo sapiens_hsa033200.70753218
70Epstein-Barr virus infection_Homo sapiens_hsa051690.70162257
71Other glycan degradation_Homo sapiens_hsa005110.69616835
72Graft-versus-host disease_Homo sapiens_hsa053320.69470584
73Metabolic pathways_Homo sapiens_hsa011000.69042085
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67446837
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.67033428
76Regulation of autophagy_Homo sapiens_hsa041400.66747224
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.65954039
78Alzheimers disease_Homo sapiens_hsa050100.65755347
79Antigen processing and presentation_Homo sapiens_hsa046120.64771902
80Allograft rejection_Homo sapiens_hsa053300.64189267
81Cardiac muscle contraction_Homo sapiens_hsa042600.63779895
82Tryptophan metabolism_Homo sapiens_hsa003800.63744813
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63062654
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61801334
85p53 signaling pathway_Homo sapiens_hsa041150.61184380
86Arginine and proline metabolism_Homo sapiens_hsa003300.60365140
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60270546
88Autoimmune thyroid disease_Homo sapiens_hsa053200.58788457
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58484084
90Herpes simplex infection_Homo sapiens_hsa051680.56900216
91Rheumatoid arthritis_Homo sapiens_hsa053230.54514092
92Chemical carcinogenesis_Homo sapiens_hsa052040.54496971
93Measles_Homo sapiens_hsa051620.54405883
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50435464
95Hematopoietic cell lineage_Homo sapiens_hsa046400.50236577
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49053978
97Viral myocarditis_Homo sapiens_hsa054160.47664858
98Butanoate metabolism_Homo sapiens_hsa006500.46543728
99Type I diabetes mellitus_Homo sapiens_hsa049400.45864561
100N-Glycan biosynthesis_Homo sapiens_hsa005100.45391593
101Apoptosis_Homo sapiens_hsa042100.45347897
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44186861
103Complement and coagulation cascades_Homo sapiens_hsa046100.43762755
104Systemic lupus erythematosus_Homo sapiens_hsa053220.43101437
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.40690603
106Shigellosis_Homo sapiens_hsa051310.40649182
107Arachidonic acid metabolism_Homo sapiens_hsa005900.39423978
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38690182
109Staphylococcus aureus infection_Homo sapiens_hsa051500.38250471
110Phototransduction_Homo sapiens_hsa047440.38181142
111Histidine metabolism_Homo sapiens_hsa003400.37250257
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36937058
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36568843
114Oocyte meiosis_Homo sapiens_hsa041140.35139203
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31607027
116Nitrogen metabolism_Homo sapiens_hsa009100.31459116
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31287180
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31082092
119Tyrosine metabolism_Homo sapiens_hsa003500.27048905
120Vibrio cholerae infection_Homo sapiens_hsa051100.22605600
121Collecting duct acid secretion_Homo sapiens_hsa049660.22013648
122Steroid biosynthesis_Homo sapiens_hsa001000.21247941

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