ALKBH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.74570922
2muscle filament sliding (GO:0030049)5.74570922
3actin-mediated cell contraction (GO:0070252)4.74206251
4sarcoplasmic reticulum calcium ion transport (GO:0070296)4.67803680
5skeletal muscle contraction (GO:0003009)4.41222783
6histone H3-K9 demethylation (GO:0033169)4.26735249
7regulation of NFAT protein import into nucleus (GO:0051532)4.20330014
8sarcomere organization (GO:0045214)4.19465638
9mitotic chromosome condensation (GO:0007076)4.14033460
10striated muscle contraction (GO:0006941)4.01298190
114-hydroxyproline metabolic process (GO:0019471)3.90191096
12gluconeogenesis (GO:0006094)3.87528617
13glycolytic process (GO:0006096)3.85688867
14NADH metabolic process (GO:0006734)3.84352559
15myofibril assembly (GO:0030239)3.76989635
16actin filament-based movement (GO:0030048)3.74737888
17cardiac muscle contraction (GO:0060048)3.69539326
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52838952
19hexose biosynthetic process (GO:0019319)3.52731939
20cardiac myofibril assembly (GO:0055003)3.51852536
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.48823752
22peptidyl-lysine dimethylation (GO:0018027)3.38117044
23mitochondrial fusion (GO:0008053)3.30769580
24L-phenylalanine catabolic process (GO:0006559)3.25871546
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25871546
26COPII vesicle coating (GO:0048208)3.21544500
27actomyosin structure organization (GO:0031032)3.20188682
28monosaccharide biosynthetic process (GO:0046364)3.19976420
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19234340
30L-phenylalanine metabolic process (GO:0006558)3.15827586
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15827586
32regulation of relaxation of muscle (GO:1901077)3.15814406
33intestinal cholesterol absorption (GO:0030299)3.13476625
34valine metabolic process (GO:0006573)3.12185396
35glycogen biosynthetic process (GO:0005978)3.10668632
36glucan biosynthetic process (GO:0009250)3.10668632
37cardiac muscle hypertrophy (GO:0003300)3.09078672
38cysteine metabolic process (GO:0006534)3.08965080
39negative regulation of potassium ion transmembrane transport (GO:1901380)3.04570428
40muscle cell cellular homeostasis (GO:0046716)3.03095921
41glycogen catabolic process (GO:0005980)3.00424554
42fructose metabolic process (GO:0006000)2.99699267
43positive regulation of fatty acid beta-oxidation (GO:0032000)2.99346375
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.98890568
45striated muscle hypertrophy (GO:0014897)2.96967953
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95597391
47adherens junction assembly (GO:0034333)2.92813649
48COPI coating of Golgi vesicle (GO:0048205)2.92225358
49Golgi transport vesicle coating (GO:0048200)2.92225358
50regulation of early endosome to late endosome transport (GO:2000641)2.91519138
51negative regulation of fatty acid biosynthetic process (GO:0045717)2.88177390
52regulation of RNA export from nucleus (GO:0046831)2.87308706
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.87286267
54lysine catabolic process (GO:0006554)2.87237143
55lysine metabolic process (GO:0006553)2.87237143
56skeletal muscle fiber development (GO:0048741)2.85842481
57spliceosomal tri-snRNP complex assembly (GO:0000244)2.85403585
58regulation of chromatin binding (GO:0035561)2.84440225
59focal adhesion assembly (GO:0048041)2.83121320
60cell-substrate adherens junction assembly (GO:0007045)2.83121320
61serine family amino acid catabolic process (GO:0009071)2.83030918
62histone lysine demethylation (GO:0070076)2.80330693
63regulation of actin filament-based movement (GO:1903115)2.77631124
64myoblast fusion (GO:0007520)2.77195900
65histone H3-K36 demethylation (GO:0070544)2.77057483
66synaptonemal complex assembly (GO:0007130)2.76256706
67histone demethylation (GO:0016577)2.75207365
68cardiac muscle hypertrophy in response to stress (GO:0014898)2.73940056
69muscle hypertrophy in response to stress (GO:0003299)2.73940056
70cardiac muscle adaptation (GO:0014887)2.73940056
71glucan catabolic process (GO:0009251)2.72544600
72response to muscle activity (GO:0014850)2.71980940
73regulation of cholesterol homeostasis (GO:2000188)2.70555391
74glyoxylate metabolic process (GO:0046487)2.70261881
75muscle cell fate commitment (GO:0042693)2.69069654
76negative regulation of cell size (GO:0045792)2.68418797
77protein localization to microtubule (GO:0035372)2.68026944
78cellular protein complex localization (GO:0034629)2.67079826
79response to inactivity (GO:0014854)2.66877824
80regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.66746599
81nuclear pore complex assembly (GO:0051292)2.66426119
82aromatic amino acid family catabolic process (GO:0009074)2.65914584
83positive regulation of hormone biosynthetic process (GO:0046886)2.65168875
84positive regulation of myotube differentiation (GO:0010831)2.64851731
85peptidyl-glutamic acid carboxylation (GO:0017187)2.63447952
86protein carboxylation (GO:0018214)2.63447952
87protein retention in ER lumen (GO:0006621)2.62806779
88muscle contraction (GO:0006936)2.62137414
89regulation of skeletal muscle contraction (GO:0014819)2.60257745
90regulation of nucleobase-containing compound transport (GO:0032239)2.58973492
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58653282
92pyruvate metabolic process (GO:0006090)2.58547643
93sodium ion export (GO:0071436)2.57853528
94urea metabolic process (GO:0019627)2.57717317
95urea cycle (GO:0000050)2.57717317
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57669513
97fatty acid beta-oxidation (GO:0006635)2.56084412
98response to nitrosative stress (GO:0051409)2.55411925
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54164331
100syncytium formation by plasma membrane fusion (GO:0000768)2.53714844
101exocrine pancreas development (GO:0031017)2.53210961
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.53057117
103positive regulation of p38MAPK cascade (GO:1900745)2.52905764
104fatty acid oxidation (GO:0019395)2.52482065
105uronic acid metabolic process (GO:0006063)2.51313328
106glucuronate metabolic process (GO:0019585)2.51313328
107paraxial mesoderm development (GO:0048339)2.51292814
108myotube differentiation (GO:0014902)2.51257157
109tyrosine metabolic process (GO:0006570)2.51231395
110glycine metabolic process (GO:0006544)2.49737158
111sulfur amino acid catabolic process (GO:0000098)2.49508086
112tricarboxylic acid cycle (GO:0006099)2.48958254
113growth hormone receptor signaling pathway (GO:0060396)2.48926010
114positive regulation of nuclease activity (GO:0032075)2.48474228
115cellular glucuronidation (GO:0052695)2.48263905
116protein demethylation (GO:0006482)2.47488207
117protein dealkylation (GO:0008214)2.47488207
118striated muscle adaptation (GO:0014888)2.47246111
119endoplasmic reticulum unfolded protein response (GO:0030968)2.46798366
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46767202
121muscle hypertrophy (GO:0014896)2.46665667
122regulation of the force of heart contraction (GO:0002026)2.46580301
123regulation of cholesterol biosynthetic process (GO:0045540)2.46538594
124glycogen metabolic process (GO:0005977)2.46528198
125synaptonemal complex organization (GO:0070193)2.45875924
126RNA stabilization (GO:0043489)2.45869238
127mRNA stabilization (GO:0048255)2.45869238
128cellular polysaccharide catabolic process (GO:0044247)2.45306987
129ER-nucleus signaling pathway (GO:0006984)2.45078712
130lipid oxidation (GO:0034440)2.44539054
131negative regulation of fatty acid transport (GO:2000192)2.44522187
132muscle organ morphogenesis (GO:0048644)2.44027914
133radial glial cell differentiation (GO:0060019)2.43344185
134serine family amino acid metabolic process (GO:0009069)2.43029874
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42471852
136positive regulation of histone deacetylation (GO:0031065)2.41501971
137cell communication by electrical coupling (GO:0010644)2.40719858
138negative regulation of skeletal muscle tissue development (GO:0048642)2.40645413
139amino-acid betaine metabolic process (GO:0006577)2.39787135
140carnitine shuttle (GO:0006853)2.39675900
141glucose metabolic process (GO:0006006)2.39601996
142cellular response to unfolded protein (GO:0034620)2.39485060
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.39005812
144regulation of cholesterol metabolic process (GO:0090181)2.37979006
145endocrine pancreas development (GO:0031018)2.37581729
146positive regulation of fatty acid oxidation (GO:0046321)2.34868768
147regulation of p38MAPK cascade (GO:1900744)2.32213151
148kynurenine metabolic process (GO:0070189)2.31799705
149intestinal absorption (GO:0050892)2.29037668
150hormone catabolic process (GO:0042447)2.28992606
151phospholipid homeostasis (GO:0055091)2.28358731
152tryptophan metabolic process (GO:0006568)2.28185655
153regulation of nuclease activity (GO:0032069)2.28115431
154nitrogen cycle metabolic process (GO:0071941)2.27540279
155cytoplasmic mRNA processing body assembly (GO:0033962)2.27457250
156low-density lipoprotein particle clearance (GO:0034383)2.26807101
157response to mercury ion (GO:0046689)2.26681870
158triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23899347
159positive regulation of hormone metabolic process (GO:0032352)2.23618695
160drug transmembrane transport (GO:0006855)2.22752091
161regulation of endothelial cell chemotaxis (GO:2001026)2.22447071
162creatine metabolic process (GO:0006600)2.22043167
163myelin maintenance (GO:0043217)2.21543797
164regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21469231
165regulation of fatty acid beta-oxidation (GO:0031998)2.21375210
166branched-chain amino acid metabolic process (GO:0009081)2.20633558
167regulation of fibrinolysis (GO:0051917)2.20502451
168fatty acid catabolic process (GO:0009062)2.19967217
169sequestering of metal ion (GO:0051238)2.18677915
170coronary vasculature morphogenesis (GO:0060977)2.18654796
1712-oxoglutarate metabolic process (GO:0006103)2.17721111
172folic acid-containing compound biosynthetic process (GO:0009396)2.17554847
173fatty acid transmembrane transport (GO:1902001)2.17229348
174cellular response to topologically incorrect protein (GO:0035967)2.16874689
175indolalkylamine catabolic process (GO:0046218)2.16839233
176tryptophan catabolic process (GO:0006569)2.16839233
177indole-containing compound catabolic process (GO:0042436)2.16839233
178positive regulation of protein kinase C signaling (GO:0090037)2.16794302
179hepatocyte apoptotic process (GO:0097284)2.16675079
180negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.16305650
181peptidyl-proline hydroxylation (GO:0019511)2.16215831
182protein hydroxylation (GO:0018126)2.15713507
183cellular modified amino acid catabolic process (GO:0042219)2.15614407
184negative regulation of fibrinolysis (GO:0051918)2.14936693
185glandular epithelial cell development (GO:0002068)2.14484831
186regulation of triglyceride catabolic process (GO:0010896)2.14325280
187ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.13416177
188complement activation, alternative pathway (GO:0006957)2.12027885
189histone H2A monoubiquitination (GO:0035518)2.11347958
190positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11319577
191negative regulation of fatty acid metabolic process (GO:0045922)2.10940518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.93322933
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.03726873
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80796245
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76569231
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.48057446
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.10642200
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02339136
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90580114
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83038572
10CLOCK_20551151_ChIP-Seq_293T_Human2.81083736
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67118954
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64272806
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43275946
14* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.41254626
15EZH2_22144423_ChIP-Seq_EOC_Human2.21052194
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19615797
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13900744
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11967169
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08783745
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05160308
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01493552
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01493552
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01493552
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98739777
25* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.95748285
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95600556
27* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95396850
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93690652
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91118882
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.89364233
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88472732
32LXR_22292898_ChIP-Seq_THP-1_Human1.86328897
33* KDM2B_26808549_Chip-Seq_DND41_Human1.85512760
34* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84705593
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.82161730
36E2F7_22180533_ChIP-Seq_HELA_Human1.81288176
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81240812
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80476160
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79901847
40VDR_21846776_ChIP-Seq_THP-1_Human1.79323643
41* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.77889724
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.76827935
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75215312
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73449831
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70167314
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68856959
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68506977
48KDM2B_26808549_Chip-Seq_K562_Human1.67735106
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66706618
50* GATA6_25053715_ChIP-Seq_YYC3_Human1.57820005
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57324107
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57173839
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57056610
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.56896320
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.55181622
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55019434
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54857423
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54458288
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54098102
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52595491
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.51652486
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50856822
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50382206
64* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49594174
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48120159
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.47883711
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.47157529
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46608164
69* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46380915
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46219378
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44587598
72CREB1_26743006_Chip-Seq_LNCaP_Human1.43064907
73ZNF263_19887448_ChIP-Seq_K562_Human1.41771479
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41633853
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.40146927
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.40146927
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.39914705
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37590282
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37566447
80* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.37079725
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36000218
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34286928
83P68_20966046_ChIP-Seq_HELA_Human1.33225103
84* SMC4_20622854_ChIP-Seq_HELA_Human1.31793753
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31520677
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30985478
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30938630
88AR_21909140_ChIP-Seq_LNCAP_Human1.29396775
89* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28830752
90* RARB_27405468_Chip-Seq_BRAIN_Mouse1.26854855
91* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25751522
92CHD1_26751641_Chip-Seq_LNCaP_Human1.25559447
93XRN2_22483619_ChIP-Seq_HELA_Human1.24980586
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24129267
95* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23636954
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23054810
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23052967
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22411022
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21831610
100* ATF3_27146783_Chip-Seq_COLON_Human1.20954269
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20393384
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20353977
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19670730
104GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18766111
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18711869
106GATA4_25053715_ChIP-Seq_YYC3_Human1.18628940
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18211767
108* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18211631
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.18158870
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18018882
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.17523738
112* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17266871
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16649027
114FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15246881
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15047136
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14460117
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.13737904
118MYC_22102868_ChIP-Seq_BL_Human1.12913911
119* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12499967
120MYC_18555785_ChIP-Seq_MESCs_Mouse1.11303846
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11169737
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.11009392
123MAF_26560356_Chip-Seq_TH1_Human1.10000042
124RACK7_27058665_Chip-Seq_MCF-7_Human1.09974552
125* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09788697
126NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09765809
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09605784
128* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09292130
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.08564215
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08453578
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07769126
132* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07686749
133* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07686749
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06321970
135SA1_27219007_Chip-Seq_ERYTHROID_Human1.05969895
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05246882
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05221326
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04678994
139ESR2_21235772_ChIP-Seq_MCF-7_Human1.04423437
140NCOR1_26117541_ChIP-Seq_K562_Human1.03596113
141* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02985922
142* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02864844
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01964403
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00750439
145TFEB_21752829_ChIP-Seq_HELA_Human1.00404967
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00320831
147MYB_26560356_Chip-Seq_TH1_Human1.00314089
148NANOG_21062744_ChIP-ChIP_HESCs_Human1.00281147
149ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98434287
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.97389018
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96166672
152FOXA1_25552417_ChIP-Seq_VCAP_Human0.94571486
153BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92966836
154* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92896031
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92679920
156* TCF7_22412390_ChIP-Seq_EML_Mouse0.92432313
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92328722
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92231995
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91548527
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91348263
161UTX_26944678_Chip-Seq_JUKART_Human0.90261806
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.88535128
163RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87743283
164* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87359715
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.87101633
166STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86438375
167SOX2_20726797_ChIP-Seq_SW620_Human0.86253802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.70265713
2MP0002139_abnormal_hepatobiliary_system3.88737297
3MP0004233_abnormal_muscle_weight3.47383115
4MP0004145_abnormal_muscle_electrophysio3.22322401
5MP0002877_abnormal_melanocyte_morpholog2.96315028
6MP0000747_muscle_weakness2.95342095
7MP0005360_urolithiasis2.90055606
8MP0000759_abnormal_skeletal_muscle2.72578196
9MP0002106_abnormal_muscle_physiology2.49975356
10MP0002269_muscular_atrophy2.48694588
11MP0005365_abnormal_bile_salt2.41466362
12MP0005085_abnormal_gallbladder_physiolo2.23555384
13MP0003252_abnormal_bile_duct2.12724142
14MP0005369_muscle_phenotype2.10948374
15MP0005408_hypopigmentation2.07148956
16MP0002009_preneoplasia2.05913011
17MP0003195_calcinosis1.90563746
18MP0003705_abnormal_hypodermis_morpholog1.84943808
19MP0005623_abnormal_meninges_morphology1.75251887
20MP0003300_gastrointestinal_ulcer1.72023288
21MP0009840_abnormal_foam_cell1.71847185
22MP0000678_abnormal_parathyroid_gland1.69829782
23MP0008260_abnormal_autophagy1.66353194
24MP0004185_abnormal_adipocyte_glucose1.61573041
25MP0005409_darkened_coat_color1.61492034
26MP0008438_abnormal_cutaneous_collagen1.59924229
27MP0003806_abnormal_nucleotide_metabolis1.58820306
28MP0005620_abnormal_muscle_contractility1.58813206
29MP0005666_abnormal_adipose_tissue1.55246570
30MP0008875_abnormal_xenobiotic_pharmacok1.53555220
31MP0004270_analgesia1.52469974
32MP0004043_abnormal_pH_regulation1.47829900
33MP0002108_abnormal_muscle_morphology1.47511902
34MP0001666_abnormal_nutrient_absorption1.47485067
35MP0002332_abnormal_exercise_endurance1.47367916
36MP0002249_abnormal_larynx_morphology1.47142006
37MP0000013_abnormal_adipose_tissue1.45865480
38MP0003950_abnormal_plasma_membrane1.45190352
39MP0005220_abnormal_exocrine_pancreas1.44019843
40MP0001730_embryonic_growth_arrest1.39850461
41MP0002972_abnormal_cardiac_muscle1.38897496
42MP0005076_abnormal_cell_differentiation1.33267709
43MP0003136_yellow_coat_color1.30601817
44MP0006054_spinal_hemorrhage1.28782969
45MP0005257_abnormal_intraocular_pressure1.27115091
46MP0010030_abnormal_orbit_morphology1.26741922
47MP0003646_muscle_fatigue1.25894186
48MP0006138_congestive_heart_failure1.23746770
49MP0005083_abnormal_biliary_tract1.22562315
50MP0002138_abnormal_hepatobiliary_system1.22334163
51MP0009053_abnormal_anal_canal1.22111337
52MP0003123_paternal_imprinting1.20619477
53MP0005332_abnormal_amino_acid1.19044356
54MP0004858_abnormal_nervous_system1.18922026
55MP0009780_abnormal_chondrocyte_physiolo1.18734692
56MP0002166_altered_tumor_susceptibility1.18194579
57MP0009384_cardiac_valve_regurgitation1.17168451
58MP0000609_abnormal_liver_physiology1.16463793
59MP0004381_abnormal_hair_follicle1.16388107
60MP0001661_extended_life_span1.15710218
61MP0003453_abnormal_keratinocyte_physiol1.15247445
62MP0003011_delayed_dark_adaptation1.15077305
63MP0009643_abnormal_urine_homeostasis1.13933764
64MP0005375_adipose_tissue_phenotype1.13892184
65MP0001346_abnormal_lacrimal_gland1.13556886
66MP0001849_ear_inflammation1.11165662
67MP0004510_myositis1.10928432
68MP0005248_abnormal_Harderian_gland1.10297129
69MP0010234_abnormal_vibrissa_follicle1.10250270
70MP0004859_abnormal_synaptic_plasticity1.09358841
71MP0003566_abnormal_cell_adhesion1.06558291
72MP0006036_abnormal_mitochondrial_physio1.05681586
73MP0002127_abnormal_cardiovascular_syste1.05569279
74MP0010329_abnormal_lipoprotein_level1.04966876
75MP0005670_abnormal_white_adipose1.01528320
76MP0000566_synostosis1.00877514
77MP0000749_muscle_degeneration1.00339881
78MP0002822_catalepsy0.99990123
79MP0003879_abnormal_hair_cell0.99597949
80MP0001944_abnormal_pancreas_morphology0.98255717
81MP0001299_abnormal_eye_distance/0.97894253
82MP0003567_abnormal_fetal_cardiomyocyte0.96186327
83MP0010368_abnormal_lymphatic_system0.94410421
84MP0000762_abnormal_tongue_morphology0.94024499
85MP0005380_embryogenesis_phenotype0.93982871
86MP0001672_abnormal_embryogenesis/_devel0.93982871
87MP0000613_abnormal_salivary_gland0.93651282
88MP0005385_cardiovascular_system_phenoty0.93444863
89MP0001544_abnormal_cardiovascular_syste0.93444863
90MP0002837_dystrophic_cardiac_calcinosis0.92442817
91MP0005451_abnormal_body_composition0.91231404
92MP0003077_abnormal_cell_cycle0.90853877
93MP0004272_abnormal_basement_membrane0.90718374
94MP0010352_gastrointestinal_tract_polyps0.90549059
95MP0003937_abnormal_limbs/digits/tail_de0.89102064
96MP0010630_abnormal_cardiac_muscle0.88973182
97MP0003984_embryonic_growth_retardation0.88799334
98MP0005023_abnormal_wound_healing0.88522534
99MP0003091_abnormal_cell_migration0.87695180
100MP0000350_abnormal_cell_proliferation0.86884747
101MP0004087_abnormal_muscle_fiber0.86290170
102MP0000733_abnormal_muscle_development0.85729986
103MP0002118_abnormal_lipid_homeostasis0.83679234
104MP0003724_increased_susceptibility_to0.83560464
105MP0004484_altered_response_of0.82834855
106MP0002088_abnormal_embryonic_growth/wei0.80869836
107MP0000750_abnormal_muscle_regeneration0.80578991
108MP0003186_abnormal_redox_activity0.80072748
109MP0000428_abnormal_craniofacial_morphol0.79679454
110MP0000534_abnormal_ureter_morphology0.79578096
111MP0004264_abnormal_extraembryonic_tissu0.78046310
112MP0000266_abnormal_heart_morphology0.77353591
113MP0005647_abnormal_sex_gland0.77233291
114MP0004215_abnormal_myocardial_fiber0.77184206
115MP0002693_abnormal_pancreas_physiology0.76864050
116MP0003868_abnormal_feces_composition0.76657418
117MP0003111_abnormal_nucleus_morphology0.76641788
118MP0002928_abnormal_bile_duct0.76225548
119MP0004084_abnormal_cardiac_muscle0.76052069
120MP0002080_prenatal_lethality0.76021374
121MP0005423_abnormal_somatic_nervous0.75764617
122MP0000003_abnormal_adipose_tissue0.75565047
123MP0000598_abnormal_liver_morphology0.75472256
124MP0003221_abnormal_cardiomyocyte_apopto0.75092832
125MP0005319_abnormal_enzyme/_coenzyme0.74378954
126MP0002114_abnormal_axial_skeleton0.74303165
127MP0002084_abnormal_developmental_patter0.74134645
128MP0000767_abnormal_smooth_muscle0.73717277
129MP0002078_abnormal_glucose_homeostasis0.73036412
130MP0005330_cardiomyopathy0.72988811
131MP0002006_tumorigenesis0.72955369
132MP0001915_intracranial_hemorrhage0.72625230
133MP0004036_abnormal_muscle_relaxation0.71346122
134MP0003329_amyloid_beta_deposits0.71167267
135MP0002168_other_aberrant_phenotype0.70969072
136MP0002085_abnormal_embryonic_tissue0.69207234
137MP0000537_abnormal_urethra_morphology0.67659189
138MP0002896_abnormal_bone_mineralization0.67640137
139MP0003279_aneurysm0.67521227
140MP0008932_abnormal_embryonic_tissue0.67306739
141MP0003828_pulmonary_edema0.67036195
142MP0002210_abnormal_sex_determination0.66701969
143MP0005395_other_phenotype0.66685562
144MP0005275_abnormal_skin_tensile0.66685507
145MP0003045_fibrosis0.66316163
146MP0003385_abnormal_body_wall0.66047160
147MP0000467_abnormal_esophagus_morphology0.65964734
148MP0002971_abnormal_brown_adipose0.64800830
149MP0004130_abnormal_muscle_cell0.64538932
150MP0003942_abnormal_urinary_system0.64499812
151MP0009703_decreased_birth_body0.64443327
152MP0004019_abnormal_vitamin_homeostasis0.64430469
153MP0002089_abnormal_postnatal_growth/wei0.64280002
154MP0000377_abnormal_hair_follicle0.63925545
155MP0000371_diluted_coat_color0.63848698
156MP0002060_abnormal_skin_morphology0.63296807
157MP0009672_abnormal_birth_weight0.63084813
158MP0001697_abnormal_embryo_size0.62469423
159MP0001879_abnormal_lymphatic_vessel0.62324170
160MP0008569_lethality_at_weaning0.62109241
161MP0003693_abnormal_embryo_hatching0.61845292
162MP0006072_abnormal_retinal_apoptosis0.61241915
163MP0004197_abnormal_fetal_growth/weight/0.60828840
164MP0006035_abnormal_mitochondrial_morpho0.60502538
165MP0005621_abnormal_cell_physiology0.60402818
166MP0005187_abnormal_penis_morphology0.59526167
167MP0002128_abnormal_blood_circulation0.59309704
168MP0001919_abnormal_reproductive_system0.58494761

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.51104335
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.45648548
3Myopathic facies (HP:0002058)4.34191248
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.17246611
5Hypoglycemic coma (HP:0001325)4.05568488
6Intrahepatic cholestasis (HP:0001406)3.97328985
7Abnormality of skeletal muscle fiber size (HP:0012084)3.76144532
8Increased variability in muscle fiber diameter (HP:0003557)3.58455691
9Distal lower limb muscle weakness (HP:0009053)3.54617450
10Hyperinsulinemic hypoglycemia (HP:0000825)3.49259862
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47315356
12Rimmed vacuoles (HP:0003805)3.35630433
13Bundle branch block (HP:0011710)3.29525895
14Abnormality of the calf musculature (HP:0001430)3.27528478
15Abnormal gallbladder physiology (HP:0012438)3.23696784
16Cholecystitis (HP:0001082)3.23696784
17Difficulty running (HP:0009046)3.11263897
18Neck muscle weakness (HP:0000467)3.07268051
19Distal arthrogryposis (HP:0005684)3.03408519
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02332019
21Hypoglycemic seizures (HP:0002173)2.98892250
22Calcaneovalgus deformity (HP:0001848)2.94535131
23Xanthomatosis (HP:0000991)2.93457347
24Hyperglycinuria (HP:0003108)2.93292102
25Exercise-induced muscle cramps (HP:0003710)2.92681765
26Muscle stiffness (HP:0003552)2.91684494
27Hyperglycemia (HP:0003074)2.90237413
28Deep venous thrombosis (HP:0002625)2.85387146
29Ulnar deviation of the wrist (HP:0003049)2.79163475
30Sudden death (HP:0001699)2.79101996
31Late onset (HP:0003584)2.73771214
32Distal lower limb amyotrophy (HP:0008944)2.72069105
33Myocardial infarction (HP:0001658)2.71741510
34Ragged-red muscle fibers (HP:0003200)2.70222617
35Ketoacidosis (HP:0001993)2.69083778
36Ketosis (HP:0001946)2.68728639
37Abnormality of the common coagulation pathway (HP:0010990)2.65230958
38Shoulder girdle muscle weakness (HP:0003547)2.63556111
39Dysmetric saccades (HP:0000641)2.61639371
40Progressive muscle weakness (HP:0003323)2.58271605
41Hyporeflexia of lower limbs (HP:0002600)2.54830874
42Myoglobinuria (HP:0002913)2.54386901
43Pancreatic islet-cell hyperplasia (HP:0004510)2.53260035
44Deformed tarsal bones (HP:0008119)2.51881549
45Pigmentary retinal degeneration (HP:0001146)2.50753229
46Fat malabsorption (HP:0002630)2.50273450
47Increased connective tissue (HP:0009025)2.46601445
48Limb-girdle muscle atrophy (HP:0003797)2.45524703
49Scapular winging (HP:0003691)2.43284951
50Hyperglycinemia (HP:0002154)2.42215792
51Spinal rigidity (HP:0003306)2.42112118
52Chorioretinal atrophy (HP:0000533)2.41428023
53Abnormality of glycine metabolism (HP:0010895)2.41265733
54Abnormality of serine family amino acid metabolism (HP:0010894)2.41265733
55Abnormality of the calcaneus (HP:0008364)2.40914894
56Subaortic stenosis (HP:0001682)2.39349445
57Abnormality of the left ventricular outflow tract (HP:0011103)2.39349445
58Joint hemorrhage (HP:0005261)2.39046055
59Abnormality of the foot musculature (HP:0001436)2.36433978
60Difficulty climbing stairs (HP:0003551)2.36141734
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.34777375
62EMG: neuropathic changes (HP:0003445)2.34646286
63Foot dorsiflexor weakness (HP:0009027)2.29920939
64Right ventricular cardiomyopathy (HP:0011663)2.28581773
65Hypoalphalipoproteinemia (HP:0003233)2.26533572
66Achilles tendon contracture (HP:0001771)2.25863622
67Muscle fiber splitting (HP:0003555)2.24320906
68Abnormality of fatty-acid metabolism (HP:0004359)2.23288768
69Prolonged partial thromboplastin time (HP:0003645)2.23272519
70Hepatocellular carcinoma (HP:0001402)2.22843559
71Abnormality of the pancreatic islet cells (HP:0006476)2.21005758
72Abnormality of endocrine pancreas physiology (HP:0012093)2.21005758
73Bulbar palsy (HP:0001283)2.19964378
74Abnormality of chloride homeostasis (HP:0011422)2.19221016
75Obstructive sleep apnea (HP:0002870)2.18758943
76Abnormality of the distal phalanges of the toes (HP:0010182)2.18030760
77Complement deficiency (HP:0004431)2.16143296
78Frequent falls (HP:0002359)2.16119724
79Abnormality of the intrinsic pathway (HP:0010989)2.16033144
80Fetal akinesia sequence (HP:0001989)2.15731953
81Lower limb amyotrophy (HP:0007210)2.13863761
82Distal upper limb amyotrophy (HP:0007149)2.13704645
83Upper limb amyotrophy (HP:0009129)2.13704645
84Limb-girdle muscle weakness (HP:0003325)2.11877139
85Insulin-resistant diabetes mellitus (HP:0000831)2.10749974
86Rhabdomyolysis (HP:0003201)2.10514645
87Esophageal varix (HP:0002040)2.10394674
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07065271
89Hypercortisolism (HP:0001578)2.05420026
90Generalized aminoaciduria (HP:0002909)2.04545141
91Exocrine pancreatic insufficiency (HP:0001738)2.04194579
92Insulin resistance (HP:0000855)2.02444508
93Abnormality of the fingertips (HP:0001211)2.01452731
94Hypolipoproteinemia (HP:0010981)2.00392934
95Facial shape deformation (HP:0011334)1.99643819
96Potter facies (HP:0002009)1.99643819
97Abnormality of the Achilles tendon (HP:0005109)1.99622651
98Abnormal atrioventricular conduction (HP:0005150)1.99417891
99Abnormality of purine metabolism (HP:0004352)1.99339791
100Symptomatic seizures (HP:0011145)1.99249945
101Cholelithiasis (HP:0001081)1.98377050
102Protrusio acetabuli (HP:0003179)1.98377005
103Epidermoid cyst (HP:0200040)1.98348713
104Abnormality of the shoulder girdle musculature (HP:0001435)1.96330773
105Heart block (HP:0012722)1.93629463
106Rectal prolapse (HP:0002035)1.91860183
107Hand muscle atrophy (HP:0009130)1.91518380
108Pelvic girdle muscle weakness (HP:0003749)1.91093237
109Hyperammonemia (HP:0001987)1.89514984
110Abnormality of glycolysis (HP:0004366)1.89222061
111Metatarsus adductus (HP:0001840)1.88168805
112Abnormality of the hip-girdle musculature (HP:0001445)1.87845402
113Abnormality of the musculature of the pelvis (HP:0001469)1.87845402
114Conjugated hyperbilirubinemia (HP:0002908)1.86897138
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.85723451
116Hyperacusis (HP:0010780)1.85638566
117Hypobetalipoproteinemia (HP:0003563)1.83151150
118Abnormality of nucleobase metabolism (HP:0010932)1.82037963
119Muscle hypertrophy of the lower extremities (HP:0008968)1.81735476
120Breech presentation (HP:0001623)1.81680887
121Areflexia of lower limbs (HP:0002522)1.81521667
122Hyperactive renin-angiotensin system (HP:0000841)1.81016981
123Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80570319
124Steatorrhea (HP:0002570)1.80506770
125Generalized muscle weakness (HP:0003324)1.79110429
126Premature rupture of membranes (HP:0001788)1.78720653
127Ventricular tachycardia (HP:0004756)1.78668264
128Abnormality of complement system (HP:0005339)1.78244354
129Vertebral arch anomaly (HP:0008438)1.76212441
130Type 1 muscle fiber predominance (HP:0003803)1.75888804
131Abnormality of the lower motor neuron (HP:0002366)1.75780957
132Calf muscle hypertrophy (HP:0008981)1.75060870
133Abnormal hemoglobin (HP:0011902)1.74962585
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74862542
135Gowers sign (HP:0003391)1.74567571
136Pseudobulbar signs (HP:0002200)1.73806586
137Absent phalangeal crease (HP:0006109)1.73609599
138Stridor (HP:0010307)1.73271148
139Gout (HP:0001997)1.71280420
140Malignant hyperthermia (HP:0002047)1.70697545
141Abnormal gallbladder morphology (HP:0012437)1.70341564
142Diaphragmatic weakness (HP:0009113)1.69376810
143Lip pit (HP:0100267)1.68710456
144Back pain (HP:0003418)1.68425695
145Myotonia (HP:0002486)1.67931743
146Ulnar bowing (HP:0003031)1.67909251
147Round ear (HP:0100830)1.67388749
148Progressive external ophthalmoplegia (HP:0000590)1.66669679
149Slender build (HP:0001533)1.66542302
150Reticulocytosis (HP:0001923)1.66161669
151Cone-rod dystrophy (HP:0000548)1.62734549
152Deep palmar crease (HP:0006191)1.61875199
153Waddling gait (HP:0002515)1.60844822
154Hammertoe (HP:0001765)1.60748378
155Hyperkalemia (HP:0002153)1.59963864
156Abnormal sex determination (HP:0012244)1.59857856
157Sex reversal (HP:0012245)1.59857856
158Atelectasis (HP:0100750)1.59437753
159Subacute progressive viral hepatitis (HP:0006572)1.59001427
160Proximal amyotrophy (HP:0007126)1.58518556
161Dilated cardiomyopathy (HP:0001644)1.58391030
162Prenatal maternal abnormality (HP:0002686)1.58043910
163Lipoatrophy (HP:0100578)1.57553615
164EMG: myopathic abnormalities (HP:0003458)1.57409409
165Abnormality of the gallbladder (HP:0005264)1.56548294
166Exercise-induced myalgia (HP:0003738)1.56302766
167Asymmetric septal hypertrophy (HP:0001670)1.55971818
168Pancreatitis (HP:0001733)1.55850471
169Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55472068
170Hyperbilirubinemia (HP:0002904)1.54968793
171Aneurysm (HP:0002617)1.54348892
172Mildly elevated creatine phosphokinase (HP:0008180)1.53529668
173Mitral stenosis (HP:0001718)1.53086587
174Abnormality of methionine metabolism (HP:0010901)1.50687862
175Muscle fiber inclusion bodies (HP:0100299)1.50230475
176Lymphangioma (HP:0100764)1.50003843
177Skin nodule (HP:0200036)1.49756699
178Hydroxyprolinuria (HP:0003080)1.48277493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B2.79642075
2LATS12.64843536
3ARAF2.56435932
4TRIB32.50623677
5PHKG12.48194510
6PHKG22.48194510
7ICK2.40044102
8MKNK22.38447174
9SMG12.37525613
10PKN22.34423416
11INSRR2.31291983
12MAP3K92.13106351
13BCKDK2.11667569
14FRK2.09734388
15SIK12.01001725
16NEK92.00635187
17TAOK31.99560216
18KSR21.92160986
19FLT31.90768480
20CDK121.77359285
21ERN11.72138625
22MOS1.70983365
23EPHB11.70090192
24BRAF1.69107016
25MAPK151.66650950
26TLK11.54248629
27MAP3K131.54094956
28TTN1.53473333
29IRAK31.51313609
30STK101.45619819
31TAOK21.44189780
32FGFR41.42890627
33PTK61.42218896
34LATS21.41346863
35STK38L1.38895161
36STK31.35792451
37KSR11.33486955
38MAP3K141.32822027
39NLK1.29039817
40WNK41.28780074
41FGFR31.27799352
42PRKD21.27411416
43MET1.25837156
44MAP3K101.24709413
45ERBB41.16262038
46RIPK11.15486813
47EEF2K1.15382887
48EPHA31.13967166
49MAP2K21.13251232
50PRKD31.12820447
51MKNK11.12390940
52HIPK21.10901952
53PBK1.08224154
54OBSCN1.06131163
55CDK191.03588921
56IRAK11.03230678
57PIK3CG1.03149641
58JAK31.02524998
59AKT21.02365542
60CDK61.01932068
61TESK11.01506381
62MAP3K30.98451322
63PDGFRA0.94455279
64SCYL20.93877280
65PASK0.93813927
66DMPK0.92208838
67RAF10.91803907
68STK390.91758502
69MARK20.90995847
70TRPM70.90124863
71MAP3K70.90020445
72CAMK1G0.90002253
73MAPK120.89941211
74CHUK0.87443367
75MST40.87290245
76TSSK60.84533208
77MAP2K30.84464609
78PAK60.84054152
79NEK10.83787115
80BRD40.81466588
81FER0.81124472
82PIM10.80276191
83STK40.80139222
84GSK3A0.78895715
85RPS6KA40.78350560
86STK380.77485304
87PRKAA20.76642315
88PNCK0.75208769
89MTOR0.73306585
90EPHA20.73043003
91LRRK20.71465750
92MELK0.70567341
93BMX0.70560955
94NUAK10.69660305
95CDK90.69329311
96PRKD10.68727399
97CDK40.68008753
98CSK0.67939923
99PDPK10.67494964
100TAOK10.67474806
101MAPK110.65644479
102JAK20.65381070
103DYRK1B0.65353574
104AKT30.64288247
105MARK10.64210307
106FGFR20.63151419
107NEK60.63007788
108IRAK20.62629060
109PAK20.62390926
110MAP2K40.60511632
111AURKA0.60221047
112TYK20.60195702
113STK240.59425560
114CDK70.59225893
115CAMK2G0.58146533
116JAK10.57900069
117RET0.57477500
118PTK20.56292570
119PIM20.55616996
120SGK20.54937414
121SGK30.54757366
122ZAP700.52167588
123MAPK100.51671124
124MAP3K20.51214995
125MUSK0.50583008
126MAP3K80.50460382
127PDGFRB0.49594555
128MAP3K110.49441765
129MST1R0.47493418
130PRKAA10.47486916
131CAMK40.47453267
132TGFBR20.46623995
133CHEK10.45882672
134IKBKE0.45600214
135SRPK10.45447998
136RPS6KB10.45389672
137TTK0.45329092
138ILK0.45322672
139MAP3K10.45238087
140SIK20.45190315
141CDK11A0.44954154
142MAPKAPK20.44927775
143WNK10.43953272
144RPS6KB20.43455933
145WNK30.43251128
146UHMK10.43134483
147NTRK10.42392820
148ITK0.42079205
149CLK10.42049696
150IKBKB0.41785745
151RPS6KA50.41347683
152PRKCH0.40855589
153PDK10.40590987
154MAPKAPK30.38385648
155MAP2K10.37854702
156ZAK0.37848386
157MARK30.37376331
158LMTK20.35446072
159CDK150.34932745
160LIMK10.34906888
161SIK30.34521209
162MAP3K50.33886135
163CDK20.32809647
164TRIM280.32365659
165CDK180.32319560
166CDK140.31840155

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.09416782
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73805307
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48036060
4Fatty acid degradation_Homo sapiens_hsa000712.35152356
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11847255
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10458199
7Tryptophan metabolism_Homo sapiens_hsa003802.05152385
8Sulfur metabolism_Homo sapiens_hsa009201.97957136
9Fructose and mannose metabolism_Homo sapiens_hsa000511.97460916
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91794513
11Selenocompound metabolism_Homo sapiens_hsa004501.91063259
12Dilated cardiomyopathy_Homo sapiens_hsa054141.89988150
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.87703599
14Protein export_Homo sapiens_hsa030601.85813043
15Circadian rhythm_Homo sapiens_hsa047101.78394543
16One carbon pool by folate_Homo sapiens_hsa006701.70358525
17Propanoate metabolism_Homo sapiens_hsa006401.69809878
18Starch and sucrose metabolism_Homo sapiens_hsa005001.69137094
19Lysine degradation_Homo sapiens_hsa003101.65337478
20Arginine biosynthesis_Homo sapiens_hsa002201.58437418
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54942290
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52634200
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51332736
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.48657184
25Fat digestion and absorption_Homo sapiens_hsa049751.47974560
26Glucagon signaling pathway_Homo sapiens_hsa049221.46641958
27Endometrial cancer_Homo sapiens_hsa052131.46630605
28Peroxisome_Homo sapiens_hsa041461.46037977
29Fatty acid metabolism_Homo sapiens_hsa012121.43549642
30Complement and coagulation cascades_Homo sapiens_hsa046101.43399952
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36278970
32PPAR signaling pathway_Homo sapiens_hsa033201.36229870
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35705472
34mTOR signaling pathway_Homo sapiens_hsa041501.34648009
35Non-small cell lung cancer_Homo sapiens_hsa052231.32418789
36Retinol metabolism_Homo sapiens_hsa008301.27440691
37Histidine metabolism_Homo sapiens_hsa003401.27202372
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26645872
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25629620
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25497846
41ErbB signaling pathway_Homo sapiens_hsa040121.24046711
42beta-Alanine metabolism_Homo sapiens_hsa004101.22550601
43Long-term potentiation_Homo sapiens_hsa047201.21258948
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21078633
45Nitrogen metabolism_Homo sapiens_hsa009101.19381739
46Glioma_Homo sapiens_hsa052141.18875693
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13657335
48Caffeine metabolism_Homo sapiens_hsa002321.13589112
49Arginine and proline metabolism_Homo sapiens_hsa003301.11198383
50VEGF signaling pathway_Homo sapiens_hsa043701.10572441
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10379772
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09283690
53Prion diseases_Homo sapiens_hsa050201.09240762
54Cardiac muscle contraction_Homo sapiens_hsa042601.07842807
55Folate biosynthesis_Homo sapiens_hsa007901.07489563
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07304914
57ABC transporters_Homo sapiens_hsa020101.06538241
58Butanoate metabolism_Homo sapiens_hsa006501.06377296
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.04405548
60Prostate cancer_Homo sapiens_hsa052151.03965569
61HIF-1 signaling pathway_Homo sapiens_hsa040661.03358907
62Chemical carcinogenesis_Homo sapiens_hsa052041.02298381
63mRNA surveillance pathway_Homo sapiens_hsa030151.01738912
64Fatty acid elongation_Homo sapiens_hsa000620.99196623
65Tyrosine metabolism_Homo sapiens_hsa003500.98213691
66Insulin resistance_Homo sapiens_hsa049310.98052405
67Oocyte meiosis_Homo sapiens_hsa041140.97245046
68Staphylococcus aureus infection_Homo sapiens_hsa051500.94434425
69Vitamin B6 metabolism_Homo sapiens_hsa007500.92863746
70Inositol phosphate metabolism_Homo sapiens_hsa005620.92021808
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91386094
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91186888
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.90251541
74Colorectal cancer_Homo sapiens_hsa052100.89855518
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88345340
76Galactose metabolism_Homo sapiens_hsa000520.87773187
77Adherens junction_Homo sapiens_hsa045200.86789251
78Cell cycle_Homo sapiens_hsa041100.86589825
79Small cell lung cancer_Homo sapiens_hsa052220.84394394
80Carbon metabolism_Homo sapiens_hsa012000.84127588
81Gap junction_Homo sapiens_hsa045400.82866920
82Biosynthesis of amino acids_Homo sapiens_hsa012300.82827894
83GnRH signaling pathway_Homo sapiens_hsa049120.82399629
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82385434
85Thyroid cancer_Homo sapiens_hsa052160.81657246
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.80287439
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78729257
88MicroRNAs in cancer_Homo sapiens_hsa052060.77354717
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76458604
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76344958
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75944473
92Oxytocin signaling pathway_Homo sapiens_hsa049210.75251080
93Pyruvate metabolism_Homo sapiens_hsa006200.75114430
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74820450
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74491399
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73141994
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72221708
98Proteoglycans in cancer_Homo sapiens_hsa052050.70224160
99Sulfur relay system_Homo sapiens_hsa041220.69769364
100Linoleic acid metabolism_Homo sapiens_hsa005910.69471137
101Other glycan degradation_Homo sapiens_hsa005110.69105426
102Protein digestion and absorption_Homo sapiens_hsa049740.69083603
103Bladder cancer_Homo sapiens_hsa052190.67300407
104Glycerolipid metabolism_Homo sapiens_hsa005610.66653738
105Melanogenesis_Homo sapiens_hsa049160.66181221
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.64521518
107ECM-receptor interaction_Homo sapiens_hsa045120.62765346
108Phenylalanine metabolism_Homo sapiens_hsa003600.62638886
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62215491
110AMPK signaling pathway_Homo sapiens_hsa041520.60706495
111Notch signaling pathway_Homo sapiens_hsa043300.60687352
112Pentose phosphate pathway_Homo sapiens_hsa000300.58700092
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58422644
114Vitamin digestion and absorption_Homo sapiens_hsa049770.58266169
115Estrogen signaling pathway_Homo sapiens_hsa049150.58239382
116Vibrio cholerae infection_Homo sapiens_hsa051100.57701789
117Focal adhesion_Homo sapiens_hsa045100.57417926
118Synaptic vesicle cycle_Homo sapiens_hsa047210.56684601
119RNA transport_Homo sapiens_hsa030130.56238414
120Type II diabetes mellitus_Homo sapiens_hsa049300.55031507
121Acute myeloid leukemia_Homo sapiens_hsa052210.55006776
122Steroid biosynthesis_Homo sapiens_hsa001000.54888993
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54011729
124Hippo signaling pathway_Homo sapiens_hsa043900.53605618
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53002724
126Prolactin signaling pathway_Homo sapiens_hsa049170.52116769
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51880282
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51634808
129Bile secretion_Homo sapiens_hsa049760.50935907
130Viral carcinogenesis_Homo sapiens_hsa052030.50934960
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.49913446
132Chronic myeloid leukemia_Homo sapiens_hsa052200.49441893
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49438523
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.49065117
135FoxO signaling pathway_Homo sapiens_hsa040680.48870273
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.47697249
137Glutathione metabolism_Homo sapiens_hsa004800.47555659
138Wnt signaling pathway_Homo sapiens_hsa043100.46046198
139Choline metabolism in cancer_Homo sapiens_hsa052310.45729542
140Calcium signaling pathway_Homo sapiens_hsa040200.44736876
141Renal cell carcinoma_Homo sapiens_hsa052110.44515106
142Amoebiasis_Homo sapiens_hsa051460.43163283
143MAPK signaling pathway_Homo sapiens_hsa040100.42405196
144Melanoma_Homo sapiens_hsa052180.41296700
145Base excision repair_Homo sapiens_hsa034100.40815503
146Tight junction_Homo sapiens_hsa045300.40766999
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40354783
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.40206308
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39037565
150Endocytosis_Homo sapiens_hsa041440.38706442
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.38688057
152TGF-beta signaling pathway_Homo sapiens_hsa043500.37397002
153Arachidonic acid metabolism_Homo sapiens_hsa005900.35936354
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.35702190
155Insulin signaling pathway_Homo sapiens_hsa049100.34834924
156Antigen processing and presentation_Homo sapiens_hsa046120.34723998
157Pancreatic cancer_Homo sapiens_hsa052120.34689444
158Toxoplasmosis_Homo sapiens_hsa051450.33870415
159Viral myocarditis_Homo sapiens_hsa054160.33847168
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.33131427
161Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32854155
162Dorso-ventral axis formation_Homo sapiens_hsa043200.32723060

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