ALKBH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac ventricle formation (GO:0003211)9.10755327
2cardiac chamber formation (GO:0003207)8.38790254
3specification of organ identity (GO:0010092)6.95716614
4pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.93913132
5protein-DNA complex disassembly (GO:0032986)5.59763545
6nucleosome disassembly (GO:0006337)5.59763545
7pyrimidine nucleotide catabolic process (GO:0006244)5.37888883
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.25404081
9negative regulation of telomere maintenance (GO:0032205)4.51436730
10positive regulation of neuroblast proliferation (GO:0002052)4.49764704
11peptidyl-arginine omega-N-methylation (GO:0035247)4.44342640
12negative regulation of erythrocyte differentiation (GO:0045647)4.33938206
13base-excision repair, AP site formation (GO:0006285)4.33799628
14polyamine metabolic process (GO:0006595)4.21569060
15regulation of mitochondrial translation (GO:0070129)4.04342908
16aggressive behavior (GO:0002118)4.02916366
17deoxyribonucleotide catabolic process (GO:0009264)3.98722542
18ubiquinone biosynthetic process (GO:0006744)3.97164096
19grooming behavior (GO:0007625)3.95029794
20regulation of translation in response to stress (GO:0043555)3.94128597
21respiratory electron transport chain (GO:0022904)3.90523462
22histone arginine methylation (GO:0034969)3.89141615
23positive regulation of uterine smooth muscle contraction (GO:0070474)3.87926689
24electron transport chain (GO:0022900)3.84775969
25peptidyl-histidine modification (GO:0018202)3.84595829
26nucleotide salvage (GO:0043173)3.76835985
27DNA deamination (GO:0045006)3.71286658
28positive regulation of prostaglandin secretion (GO:0032308)3.65470965
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61939544
30respiratory chain complex IV assembly (GO:0008535)3.60662780
31deoxyribose phosphate catabolic process (GO:0046386)3.60002992
32peptidyl-arginine methylation (GO:0018216)3.58798495
33peptidyl-arginine N-methylation (GO:0035246)3.58798495
34cellular response to interferon-beta (GO:0035458)3.55737158
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53628896
36negative regulation of B cell apoptotic process (GO:0002903)3.47201820
37mannosylation (GO:0097502)3.47032822
38ubiquinone metabolic process (GO:0006743)3.46104533
39protein complex biogenesis (GO:0070271)3.45650637
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43860931
41deoxyribose phosphate biosynthetic process (GO:0046385)3.43068290
422-deoxyribonucleotide biosynthetic process (GO:0009265)3.43068290
43lipopolysaccharide biosynthetic process (GO:0009103)3.39721531
44GMP metabolic process (GO:0046037)3.37787660
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37348744
46ATP synthesis coupled proton transport (GO:0015986)3.37348744
47ribosomal small subunit assembly (GO:0000028)3.36945363
48mitochondrion morphogenesis (GO:0070584)3.35589427
49cytochrome complex assembly (GO:0017004)3.28387721
50protein neddylation (GO:0045116)3.28081943
51signal peptide processing (GO:0006465)3.23957031
52cellular response to thyroid hormone stimulus (GO:0097067)3.23333407
53regulation of uterine smooth muscle contraction (GO:0070472)3.22880533
54proteasome assembly (GO:0043248)3.20121476
55regulation of gene expression by genetic imprinting (GO:0006349)3.20037164
56protein kinase C signaling (GO:0070528)3.16076012
57viral protein processing (GO:0019082)3.15475374
58cullin deneddylation (GO:0010388)3.14054846
59inositol phosphate dephosphorylation (GO:0046855)3.12912780
60phosphorylated carbohydrate dephosphorylation (GO:0046838)3.12912780
612-deoxyribonucleotide metabolic process (GO:0009394)3.09703346
62quinone biosynthetic process (GO:1901663)3.08073975
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.07085982
64NADH dehydrogenase complex assembly (GO:0010257)3.07085982
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07085982
66purine deoxyribonucleotide catabolic process (GO:0009155)3.07051428
67mitochondrial respiratory chain complex assembly (GO:0033108)3.07020722
68positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.05066017
69protein deneddylation (GO:0000338)3.04453088
70NIK/NF-kappaB signaling (GO:0038061)3.03584937
71regulation of synaptic vesicle exocytosis (GO:2000300)3.02839934
72guanosine-containing compound biosynthetic process (GO:1901070)3.01412033
73amine catabolic process (GO:0009310)3.00047870
74cellular biogenic amine catabolic process (GO:0042402)3.00047870
75GTP biosynthetic process (GO:0006183)2.99923848
76histone mRNA metabolic process (GO:0008334)2.97481485
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96730218
78response to misfolded protein (GO:0051788)2.94745929
79mature B cell differentiation involved in immune response (GO:0002313)2.94400512
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.93009244
81pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92061926
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91683662
83lipopolysaccharide metabolic process (GO:0008653)2.90357087
84negative regulation of defense response to virus (GO:0050687)2.87473053
85positive regulation of fatty acid transport (GO:2000193)2.87326233
86positive regulation of icosanoid secretion (GO:0032305)2.87118209
87neuronal action potential propagation (GO:0019227)2.86661889
88catecholamine transport (GO:0051937)2.86296784
89negative regulation of DNA-templated transcription, elongation (GO:0032785)2.85412636
90actin nucleation (GO:0045010)2.84941920
91positive regulation of organic acid transport (GO:0032892)2.83419772
92spliceosomal snRNP assembly (GO:0000387)2.83040574
93genetic imprinting (GO:0071514)2.81222647
94GDP-mannose metabolic process (GO:0019673)2.80444568
95negative regulation of Notch signaling pathway (GO:0045746)2.79923203
96regulation of neuroblast proliferation (GO:1902692)2.79679034
97positive regulation of systemic arterial blood pressure (GO:0003084)2.78290538
98positive regulation of amino acid transport (GO:0051957)2.77777106
99T-helper 1 type immune response (GO:0042088)2.75270385
100chaperone-mediated protein transport (GO:0072321)2.74419132
101DNA damage response, detection of DNA damage (GO:0042769)2.74210880
102phosphatidylglycerol biosynthetic process (GO:0006655)2.74123194
103purinergic nucleotide receptor signaling pathway (GO:0035590)2.73865801
104sequestering of actin monomers (GO:0042989)2.73580642
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72782407
106regulation of synaptic vesicle transport (GO:1902803)2.71755449
107iron-sulfur cluster assembly (GO:0016226)2.70279899
108metallo-sulfur cluster assembly (GO:0031163)2.70279899
109pseudouridine synthesis (GO:0001522)2.68179194
110purine nucleotide salvage (GO:0032261)2.68038159
111deoxyribose phosphate metabolic process (GO:0019692)2.67957612
112alkaloid metabolic process (GO:0009820)2.67641395
113deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66204775
114CTP biosynthetic process (GO:0006241)2.66168064
115CTP metabolic process (GO:0046036)2.66168064
116behavioral response to ethanol (GO:0048149)2.65861007
117NAD biosynthetic process (GO:0009435)2.65457603
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65412277
119regulation of transmission of nerve impulse (GO:0051969)2.65051157
120inositol phosphate catabolic process (GO:0071545)2.65017699
121microtubule severing (GO:0051013)2.63360970
122branched-chain amino acid catabolic process (GO:0009083)2.62288510
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62068883
124positive regulation of neurotransmitter secretion (GO:0001956)2.61856052
125opioid receptor signaling pathway (GO:0038003)2.61426991
126inositol metabolic process (GO:0006020)2.61048389
127preassembly of GPI anchor in ER membrane (GO:0016254)2.60883353
128regulation of prostaglandin secretion (GO:0032306)2.60821072
129tRNA modification (GO:0006400)2.59761135
130pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.57351625
131regulation of cellular amino acid metabolic process (GO:0006521)2.57328953
132coenzyme A biosynthetic process (GO:0015937)2.56883945
133response to interferon-beta (GO:0035456)2.53806485
134platelet dense granule organization (GO:0060155)2.53684477
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.53329707
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.53302222
137cellular metabolic compound salvage (GO:0043094)2.52190612
138positive thymic T cell selection (GO:0045059)2.52067128
139misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.51852247
140UV protection (GO:0009650)2.51480520
141dopamine transport (GO:0015872)2.51216317
142regulation of B cell apoptotic process (GO:0002902)2.49963637
143response to dietary excess (GO:0002021)2.49884230
144spliceosomal complex assembly (GO:0000245)2.49614797
145negative regulation of response to biotic stimulus (GO:0002832)2.48684064
146UTP biosynthetic process (GO:0006228)2.48351216
147righting reflex (GO:0060013)2.47508518
148maternal behavior (GO:0042711)2.47332966
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46879240
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46879240
151postsynaptic membrane organization (GO:0001941)2.46875218
152protein maturation by protein folding (GO:0022417)2.45572023
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.45314134
154positive regulation of protein homodimerization activity (GO:0090073)2.45081143
155translation (GO:0006412)2.44192476
156positive regulation of neural precursor cell proliferation (GO:2000179)2.43176685
157SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42874520
158cotranslational protein targeting to membrane (GO:0006613)2.41995999
159negative thymic T cell selection (GO:0045060)2.40044998
160dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.39854518
161female mating behavior (GO:0060180)2.39835069
162positive regulation of neurotransmitter transport (GO:0051590)2.39813648
163regulation of female receptivity (GO:0045924)2.39489284
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39379143
165purine deoxyribonucleotide metabolic process (GO:0009151)2.39049923
166oxidative phosphorylation (GO:0006119)2.38909860
167immunoglobulin mediated immune response (GO:0016064)2.37968076
168post-embryonic morphogenesis (GO:0009886)2.36043112
169polyamine biosynthetic process (GO:0006596)2.35763935
170antigen processing and presentation of endogenous antigen (GO:0019883)2.35613224
171pyrimidine nucleotide metabolic process (GO:0006220)2.34769345
172cellular response to exogenous dsRNA (GO:0071360)2.33029244
173negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.32682254
174mitochondrial RNA metabolic process (GO:0000959)2.32425682
175mucosal-associated lymphoid tissue development (GO:0048537)2.32027165
176Peyers patch development (GO:0048541)2.32027165
177deoxyribonucleotide metabolic process (GO:0009262)2.31071001
178protein-cofactor linkage (GO:0018065)2.30422875
179branched-chain amino acid metabolic process (GO:0009081)2.28406312
180secondary heart field specification (GO:0003139)10.0747783
181heart field specification (GO:0003128)10.0747783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human6.03400335
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.30185990
3IGF1R_20145208_ChIP-Seq_DFB_Human4.38165667
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24976893
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72613293
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.66636059
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.60907097
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59204776
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42543006
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.90827507
11EZH2_22144423_ChIP-Seq_EOC_Human2.85891131
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82731557
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77957102
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.66191342
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.51419175
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.49211498
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.47987541
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47189896
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.26221522
20BCL6_27268052_Chip-Seq_Bcells_Human2.24216007
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20622685
22CIITA_25753668_ChIP-Seq_RAJI_Human2.17770454
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17187036
24VDR_21846776_ChIP-Seq_THP-1_Human2.15208942
25GBX2_23144817_ChIP-Seq_PC3_Human2.09179610
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09130136
27P68_20966046_ChIP-Seq_HELA_Human2.06111820
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.95074146
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.94831099
30BCOR_27268052_Chip-Seq_Bcells_Human1.91062502
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86277916
32* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.80264692
33* MAF_26560356_Chip-Seq_TH2_Human1.76132604
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.75147447
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74782656
36MYC_22102868_ChIP-Seq_BL_Human1.73483159
37PHF8_20622854_ChIP-Seq_HELA_Human1.71817733
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71654204
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70218685
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63397180
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.63183805
42E2F1_20622854_ChIP-Seq_HELA_Human1.62926780
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61916471
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61235420
45FOXP3_21729870_ChIP-Seq_TREG_Human1.60979455
46LXR_22292898_ChIP-Seq_THP-1_Human1.58877222
47KDM5A_27292631_Chip-Seq_BREAST_Human1.55683856
48* ELK1_19687146_ChIP-ChIP_HELA_Human1.55381671
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54567633
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53893178
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53368193
52VDR_23849224_ChIP-Seq_CD4+_Human1.51195163
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.50554026
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.49858887
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49494297
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48774584
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46915959
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44723804
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.44254200
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43466482
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42708606
62CTCF_20526341_ChIP-Seq_ESCs_Human1.41874325
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40366448
64GABP_19822575_ChIP-Seq_HepG2_Human1.39971331
65UTX_26944678_Chip-Seq_JUKART_Human1.39970855
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37221892
67P300_27268052_Chip-Seq_Bcells_Human1.37091205
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36959462
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36371642
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36316578
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36108529
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.35401516
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34536153
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.34297313
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.32773527
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32727913
77MAF_26560356_Chip-Seq_TH1_Human1.32553440
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31619386
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31314335
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29994205
81* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29402002
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28475932
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27594919
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27465203
85* CTCF_26484167_Chip-Seq_Bcells_Mouse1.27347463
86CTCF_21964334_Chip-Seq_Bcells_Human1.26316168
87MYC_18940864_ChIP-ChIP_HL60_Human1.25817708
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.22523823
89* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22386967
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21005544
91* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20988186
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20492851
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20164593
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19892178
95TP53_22127205_ChIP-Seq_IMR90_Human1.19352771
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18877723
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18447292
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.18205482
99ERA_21632823_ChIP-Seq_H3396_Human1.16185282
100REST_21632747_ChIP-Seq_MESCs_Mouse1.15870519
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.15438291
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15373223
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.14597992
104TAF15_26573619_Chip-Seq_HEK293_Human1.14085125
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13435706
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13380150
107ZNF274_21170338_ChIP-Seq_K562_Hela1.13250628
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12739667
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10950695
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10239594
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08846207
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.08320808
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.08231533
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07913082
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07911005
116RAC3_21632823_ChIP-Seq_H3396_Human1.07755049
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06977750
118SCL_19346495_ChIP-Seq_HPC-7_Human1.06935000
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06656978
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06248887
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06130238
122ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05700570
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05386030
124SPI1_20517297_ChIP-Seq_HL60_Human1.05351243
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.00712095
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99464053
127CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99008527
128RNF2_27304074_Chip-Seq_NSC_Mouse0.98165754
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97772745
130DCP1A_22483619_ChIP-Seq_HELA_Human0.95824350
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95795436
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95613172
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95552289
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.92784544
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.92123894
136* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91833799
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91734695
138* XRN2_22483619_ChIP-Seq_HELA_Human0.91015054
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89587099
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.88225465
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87805627
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84148305
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.83579745
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82329822
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82090902
146EZH2_27304074_Chip-Seq_ESCs_Mouse0.80908041
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80587321
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79713990
149VDR_22108803_ChIP-Seq_LS180_Human0.79145599
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78699245
151TTF2_22483619_ChIP-Seq_HELA_Human0.77996422
152FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77360148
153RARB_27405468_Chip-Seq_BRAIN_Mouse0.75531477
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75048173
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74166596
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73735545
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73195194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.02615148
2MP0006292_abnormal_olfactory_placode2.79926702
3MP0005451_abnormal_body_composition2.69137901
4MP0001986_abnormal_taste_sensitivity2.65108915
5MP0004142_abnormal_muscle_tone2.59974860
6MP0003880_abnormal_central_pattern2.50741387
7MP0002638_abnormal_pupillary_reflex2.40274953
8MP0006276_abnormal_autonomic_nervous2.36053935
9MP0002009_preneoplasia2.35922884
10MP0003763_abnormal_thymus_physiology2.33347944
11MP0001968_abnormal_touch/_nociception2.22944213
12MP0010386_abnormal_urinary_bladder2.11518762
13MP0004885_abnormal_endolymph2.06627505
14MP0005058_abnormal_lysosome_morphology2.03136906
15MP0001800_abnormal_humoral_immune2.00620271
16MP0005646_abnormal_pituitary_gland2.00207977
17MP0008058_abnormal_DNA_repair1.98321530
18MP0003635_abnormal_synaptic_transmissio1.98169367
19MP0002723_abnormal_immune_serum1.93063753
20MP0001188_hyperpigmentation1.92689556
21MP0002572_abnormal_emotion/affect_behav1.92614133
22MP0009745_abnormal_behavioral_response1.91188686
23MP0001905_abnormal_dopamine_level1.87903555
24MP0002876_abnormal_thyroid_physiology1.87643444
25MP0003786_premature_aging1.86514748
26MP0005423_abnormal_somatic_nervous1.86442349
27MP0001529_abnormal_vocalization1.85967787
28MP0002272_abnormal_nervous_system1.83298207
29MP0005000_abnormal_immune_tolerance1.82907949
30MP0005379_endocrine/exocrine_gland_phen1.80989818
31MP0002063_abnormal_learning/memory/cond1.80849460
32MP0002420_abnormal_adaptive_immunity1.80739823
33MP0001819_abnormal_immune_cell1.79341023
34MP0006072_abnormal_retinal_apoptosis1.76563018
35MP0009379_abnormal_foot_pigmentation1.76187232
36MP0005409_darkened_coat_color1.74856054
37MP0002064_seizures1.74055662
38MP0002163_abnormal_gland_morphology1.72439121
39MP0002736_abnormal_nociception_after1.70595311
40MP0002452_abnormal_antigen_presenting1.69606197
41MP0002557_abnormal_social/conspecific_i1.67649142
42MP0003122_maternal_imprinting1.67582994
43MP0003436_decreased_susceptibility_to1.63102911
44MP0005025_abnormal_response_to1.62832789
45MP0003718_maternal_effect1.61532324
46MP0005645_abnormal_hypothalamus_physiol1.60932545
47MP0001790_abnormal_immune_system1.59428195
48MP0005387_immune_system_phenotype1.59428195
49MP0001486_abnormal_startle_reflex1.57269996
50MP0003890_abnormal_embryonic-extraembry1.54908013
51MP0002398_abnormal_bone_marrow1.54413529
52MP0002734_abnormal_mechanical_nocicepti1.54202056
53MP0002909_abnormal_adrenal_gland1.51944316
54MP0000689_abnormal_spleen_morphology1.50528581
55MP0002653_abnormal_ependyma_morphology1.50072169
56MP0002933_joint_inflammation1.49567824
57MP0002735_abnormal_chemical_nociception1.49001187
58MP0002067_abnormal_sensory_capabilities1.47370451
59MP0000685_abnormal_immune_system1.46326585
60MP0003693_abnormal_embryo_hatching1.45879568
61MP0000716_abnormal_immune_system1.45608877
62MP0005671_abnormal_response_to1.45372370
63MP0001984_abnormal_olfaction1.40774227
64MP0001873_stomach_inflammation1.40577238
65MP0001970_abnormal_pain_threshold1.39565951
66MP0002722_abnormal_immune_system1.39328638
67MP0005551_abnormal_eye_electrophysiolog1.39210099
68MP0002837_dystrophic_cardiac_calcinosis1.33978864
69MP0003183_abnormal_peptide_metabolism1.32499595
70MP0009333_abnormal_splenocyte_physiolog1.30263914
71MP0009278_abnormal_bone_marrow1.30237555
72MP0000372_irregular_coat_pigmentation1.29093853
73MP0002751_abnormal_autonomic_nervous1.28571068
74MP0003787_abnormal_imprinting1.28355129
75MP0002429_abnormal_blood_cell1.27087198
76MP0002138_abnormal_hepatobiliary_system1.26729422
77MP0003137_abnormal_impulse_conducting1.26442814
78MP0002405_respiratory_system_inflammati1.26105346
79MP0000631_abnormal_neuroendocrine_gland1.25536244
80MP0000703_abnormal_thymus_morphology1.24534561
81MP0003315_abnormal_perineum_morphology1.23927888
82MP0009764_decreased_sensitivity_to1.23463210
83MP0005253_abnormal_eye_physiology1.21484420
84MP0003172_abnormal_lysosome_physiology1.21087981
85MP0002693_abnormal_pancreas_physiology1.19945772
86MP0002102_abnormal_ear_morphology1.19872121
87MP0004133_heterotaxia1.19335114
88MP0008872_abnormal_physiological_respon1.19244954
89MP0009046_muscle_twitch1.19047435
90MP0002184_abnormal_innervation1.18854339
91MP0000678_abnormal_parathyroid_gland1.18561267
92MP0004510_myositis1.18428685
93MP0004043_abnormal_pH_regulation1.17211800
94MP0002822_catalepsy1.16723721
95MP0008875_abnormal_xenobiotic_pharmacok1.16143003
96MP0005394_taste/olfaction_phenotype1.15953386
97MP0005499_abnormal_olfactory_system1.15953386
98MP0005310_abnormal_salivary_gland1.14752902
99MP0002733_abnormal_thermal_nociception1.12854959
100MP0002148_abnormal_hypersensitivity_rea1.12660028
101MP0001545_abnormal_hematopoietic_system1.12323554
102MP0005397_hematopoietic_system_phenotyp1.12323554
103MP0000003_abnormal_adipose_tissue1.12071649
104MP0001501_abnormal_sleep_pattern1.10659627
105MP0000681_abnormal_thyroid_gland1.10305513
106MP0001485_abnormal_pinna_reflex1.09299414
107MP0002229_neurodegeneration1.08635197
108MP0001764_abnormal_homeostasis1.08428906
109MP0004859_abnormal_synaptic_plasticity1.07046918
110MP0001963_abnormal_hearing_physiology1.05709784
111MP0001845_abnormal_inflammatory_respons1.05588949
112MP0002019_abnormal_tumor_incidence1.05568438
113MP0002419_abnormal_innate_immunity1.03801558
114MP0004742_abnormal_vestibular_system1.03139724
115MP0002254_reproductive_system_inflammat1.02984793
116MP0004145_abnormal_muscle_electrophysio1.02946701
117MP0004270_analgesia1.01080286
118MP0008469_abnormal_protein_level1.00470155
119MP0004924_abnormal_behavior1.00458991
120MP0005386_behavior/neurological_phenoty1.00458991
121MP0003866_abnormal_defecation1.00179909
122MP0006035_abnormal_mitochondrial_morpho0.99102177
123MP0008789_abnormal_olfactory_epithelium0.98693471
124MP0003136_yellow_coat_color0.97555600
125MP0002127_abnormal_cardiovascular_syste0.97400898
126MP0006036_abnormal_mitochondrial_physio0.97292790
127MP0010307_abnormal_tumor_latency0.95666665
128MP0000465_gastrointestinal_hemorrhage0.95274818
129MP0001502_abnormal_circadian_rhythm0.94922741
130MP0008932_abnormal_embryonic_tissue0.93083073
131MP0004147_increased_porphyrin_level0.92084220
132MP0001835_abnormal_antigen_presentation0.91973295
133MP0000026_abnormal_inner_ear0.90136323
134MP0002234_abnormal_pharynx_morphology0.89676460
135MP0009785_altered_susceptibility_to0.88741190
136MP0003186_abnormal_redox_activity0.88147436
137MP0004085_abnormal_heartbeat0.87792839
138MP0000778_abnormal_nervous_system0.87172974
139MP0000516_abnormal_urinary_system0.85803776
140MP0005367_renal/urinary_system_phenotyp0.85803776
141MP0005075_abnormal_melanosome_morpholog0.85795923
142MP0003724_increased_susceptibility_to0.85681886
143MP0003111_abnormal_nucleus_morphology0.85263882
144MP0003938_abnormal_ear_development0.84894501
145MP0005174_abnormal_tail_pigmentation0.84812456
146MP0002066_abnormal_motor_capabilities/c0.84569314
147MP0002882_abnormal_neuron_morphology0.83794078
148MP0001348_abnormal_lacrimal_gland0.83764136
149MP0008995_early_reproductive_senescence0.83413499
150MP0001919_abnormal_reproductive_system0.83114202
151MP0003195_calcinosis0.81888637
152MP0009697_abnormal_copulation0.81405963
153MP0000538_abnormal_urinary_bladder0.81251959
154MP0003879_abnormal_hair_cell0.79282173
155MP0003633_abnormal_nervous_system0.78674316
156MP0000230_abnormal_systemic_arterial0.78580387
157MP0005410_abnormal_fertilization0.78417602
158MP0002752_abnormal_somatic_nervous0.78199640
159MP0000015_abnormal_ear_pigmentation0.77374161
160MP0008569_lethality_at_weaning0.77329946
161MP0003878_abnormal_ear_physiology0.76713856
162MP0005377_hearing/vestibular/ear_phenot0.76713856
163MP0008877_abnormal_DNA_methylation0.73587982
164MP0005464_abnormal_platelet_physiology0.71248915
165MP0000750_abnormal_muscle_regeneration0.69878631
166MP0000358_abnormal_cell_content/0.67773480

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)6.62750795
2Hepatic necrosis (HP:0002605)5.61714063
3Mitochondrial inheritance (HP:0001427)5.40194469
4Acute necrotizing encephalopathy (HP:0006965)4.70105672
5Neuroendocrine neoplasm (HP:0100634)4.69867318
6Pheochromocytoma (HP:0002666)4.45120754
7Increased CSF lactate (HP:0002490)4.39659338
8Abnormal mitochondria in muscle tissue (HP:0008316)4.30545424
9Elevated erythrocyte sedimentation rate (HP:0003565)4.18241234
10Aplastic anemia (HP:0001915)3.94280029
11Hypothermia (HP:0002045)3.91556135
12Capillary hemangiomas (HP:0005306)3.74658106
13Progressive macrocephaly (HP:0004481)3.70197691
14Abnormality of liposaccharide metabolism (HP:0010968)3.54798155
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.54798155
16Abnormality of glycolipid metabolism (HP:0010969)3.54798155
17Acute encephalopathy (HP:0006846)3.52787492
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33972421
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33972421
20Pancreatic cysts (HP:0001737)3.30058582
21Emotional lability (HP:0000712)3.28668301
22Type I transferrin isoform profile (HP:0003642)3.22767284
23Increased muscle lipid content (HP:0009058)3.19626260
24Facial diplegia (HP:0001349)3.11111758
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10684908
26Respiratory failure (HP:0002878)3.09041329
27Panhypogammaglobulinemia (HP:0003139)3.07732892
28Rimmed vacuoles (HP:0003805)3.05621951
29Severe visual impairment (HP:0001141)3.01667395
30Hyperventilation (HP:0002883)3.01195680
31Progressive microcephaly (HP:0000253)2.99093943
32Optic disc pallor (HP:0000543)2.96389979
33Retinal dysplasia (HP:0007973)2.93438385
34Abnormality of hair growth rate (HP:0011363)2.93148699
35Slow-growing hair (HP:0002217)2.93148699
36Increased serum lactate (HP:0002151)2.87603766
37Scanning speech (HP:0002168)2.86226825
38Agammaglobulinemia (HP:0004432)2.83456230
39Narrow nasal bridge (HP:0000446)2.79056921
40Lactic acidosis (HP:0003128)2.78316064
41IgG deficiency (HP:0004315)2.73585820
42Abnormality of the intervertebral disk (HP:0005108)2.73424861
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72228799
44Recurrent fungal infections (HP:0002841)2.69059465
45Broad distal phalanx of finger (HP:0009836)2.69041824
46Type II lissencephaly (HP:0007260)2.68273721
47Stomatitis (HP:0010280)2.66594891
48Abnormal rod and cone electroretinograms (HP:0008323)2.61221204
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59318948
50True hermaphroditism (HP:0010459)2.57409764
51Medial flaring of the eyebrow (HP:0010747)2.56623591
52Tinnitus (HP:0000360)2.55234971
53Severe combined immunodeficiency (HP:0004430)2.48230388
54Mesangial abnormality (HP:0001966)2.47556305
55Exercise intolerance (HP:0003546)2.47131862
56Recurrent cutaneous fungal infections (HP:0011370)2.46591821
57Chronic mucocutaneous candidiasis (HP:0002728)2.46591821
58Microretrognathia (HP:0000308)2.45973156
59CNS demyelination (HP:0007305)2.44822365
60Increased IgM level (HP:0003496)2.42829778
61Ragged-red muscle fibers (HP:0003200)2.42570222
623-Methylglutaconic aciduria (HP:0003535)2.38612943
63Leukodystrophy (HP:0002415)2.37789136
64Poor eye contact (HP:0000817)2.36362822
65Concave nail (HP:0001598)2.36358958
66Abnormality of T cell physiology (HP:0011840)2.34568921
67Gait imbalance (HP:0002141)2.33948271
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.33817792
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33362560
70Opisthotonus (HP:0002179)2.32820071
71Congenital primary aphakia (HP:0007707)2.32699104
72Neoplasm of the peripheral nervous system (HP:0100007)2.32689021
73Petechiae (HP:0000967)2.31165586
74Decreased circulating renin level (HP:0003351)2.30685874
75Abnormality of cells of the erythroid lineage (HP:0012130)2.30337017
76Prostate neoplasm (HP:0100787)2.26177520
77Cerebral edema (HP:0002181)2.24102258
78Nephrogenic diabetes insipidus (HP:0009806)2.24018624
79Severe muscular hypotonia (HP:0006829)2.23548418
80Abnormal glycosylation (HP:0012345)2.21567594
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21567594
82Abnormal protein N-linked glycosylation (HP:0012347)2.21567594
83Abnormal protein glycosylation (HP:0012346)2.21567594
84Cerebral hypomyelination (HP:0006808)2.21398027
85Pancreatic fibrosis (HP:0100732)2.19952831
86Testicular atrophy (HP:0000029)2.19749531
87Abnormality of B cell number (HP:0010975)2.19241713
88Focal motor seizures (HP:0011153)2.18149141
89Epileptic encephalopathy (HP:0200134)2.17581637
90Attenuation of retinal blood vessels (HP:0007843)2.17499407
91Prolonged neonatal jaundice (HP:0006579)2.16322296
92Large for gestational age (HP:0001520)2.16318781
93Progressive cerebellar ataxia (HP:0002073)2.13888912
94Chronic obstructive pulmonary disease (HP:0006510)2.12329683
95Obstructive lung disease (HP:0006536)2.12329683
96Aqueductal stenosis (HP:0002410)2.12300176
97Myokymia (HP:0002411)2.11590387
98Clubbing of toes (HP:0100760)2.11309969
99Hemangiomatosis (HP:0007461)2.08602473
100B lymphocytopenia (HP:0010976)2.06975512
101Mediastinal lymphadenopathy (HP:0100721)2.06720476
102Increased hepatocellular lipid droplets (HP:0006565)2.05307911
103Supernumerary bones of the axial skeleton (HP:0009144)2.03852315
104Congenital stationary night blindness (HP:0007642)2.03574503
105Renal Fanconi syndrome (HP:0001994)2.02898271
106Bilateral microphthalmos (HP:0007633)2.00857673
107Cleft eyelid (HP:0000625)2.00386122
108Squamous cell carcinoma (HP:0002860)1.98599723
109Cerebral hemorrhage (HP:0001342)1.98593431
110Generalized hypotonia (HP:0001290)1.98590169
111Abnormality of the heme biosynthetic pathway (HP:0010472)1.97970410
112Hypertensive crisis (HP:0100735)1.94113266
113Patellar aplasia (HP:0006443)1.93842236
114Abnormality of magnesium homeostasis (HP:0004921)1.93801799
115Lissencephaly (HP:0001339)1.91919406
116Abnormality of T cells (HP:0002843)1.90812572
117Meningitis (HP:0001287)1.89538372
118Abnormal hair whorl (HP:0010721)1.89050207
119Dicarboxylic aciduria (HP:0003215)1.88385014
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88385014
121Clumsiness (HP:0002312)1.88368523
122Recurrent viral infections (HP:0004429)1.88052458
123Febrile seizures (HP:0002373)1.87424453
124Optic nerve coloboma (HP:0000588)1.87270556
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.86765686
126Psychosis (HP:0000709)1.86400070
127Brushfield spots (HP:0001088)1.84453804
128Median cleft lip (HP:0000161)1.82636269
129Gliosis (HP:0002171)1.82417915
130Fatigue (HP:0012378)1.80661153
131Lipid accumulation in hepatocytes (HP:0006561)1.79178999
132Thrombocytosis (HP:0001894)1.78356588
133Granulocytopenia (HP:0001913)1.77737798
134Type 2 muscle fiber atrophy (HP:0003554)1.77518312
135Microvesicular hepatic steatosis (HP:0001414)1.76417630
136Ulnar claw (HP:0001178)1.75943498
137Aplasia/hypoplasia of the uterus (HP:0008684)1.75590911
138Aplasia/Hypoplasia of the patella (HP:0006498)1.75163169
139Poor coordination (HP:0002370)1.74954733
140Atonic seizures (HP:0010819)1.74939566
141Abnormal number of erythroid precursors (HP:0012131)1.73798607
142X-linked dominant inheritance (HP:0001423)1.73332038
143Cerebral palsy (HP:0100021)1.72446494
144Split foot (HP:0001839)1.71945553
145Vaginal atresia (HP:0000148)1.71321133
146Abnormality of the prostate (HP:0008775)1.71270971
147Combined immunodeficiency (HP:0005387)1.70983313
148Cortical visual impairment (HP:0100704)1.70957001
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70574284
150Cutaneous photosensitivity (HP:0000992)1.69967932
151Nonprogressive disorder (HP:0003680)1.69919782
152Global brain atrophy (HP:0002283)1.68160762
153Unsteady gait (HP:0002317)1.66585395
154Genital tract atresia (HP:0001827)1.66539736
155Birth length less than 3rd percentile (HP:0003561)1.66452704
156Abnormality of polysaccharide metabolism (HP:0011012)1.66149895
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66149895
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66149895
159Visual hallucinations (HP:0002367)1.65599107
160Anxiety (HP:0000739)1.64488073
161Increased intramyocellular lipid droplets (HP:0012240)1.63795747
162Pancytopenia (HP:0001876)1.62810594
163CNS hypomyelination (HP:0003429)1.61196932
164Blue irides (HP:0000635)1.58417591
165Abnormal pupillary function (HP:0007686)1.58325036
166Muscle fiber atrophy (HP:0100295)1.55914783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.00446640
2ACVR1B4.63543202
3MAP3K124.37911639
4CASK4.32720570
5BMPR1B3.74965466
6KDR3.72130296
7PINK13.47057652
8SCYL23.44808704
9STK163.16683444
10TESK23.08713606
11NME12.97087273
12WNK12.36269459
13VRK22.35740815
14ZAK2.25867745
15TGFBR12.09477130
16MUSK1.92272728
17PNCK1.92064551
18TBK11.91792603
19LIMK11.86238740
20MAP2K71.82593230
21GRK61.74183075
22SIK21.66984088
23TNIK1.66974207
24CDK191.66245444
25MYLK1.61465242
26MAP3K11.58141443
27BMPR21.58052316
28SRPK11.57888885
29IKBKE1.50796618
30BRAF1.49161522
31STK41.48947422
32ARAF1.45816058
33NME21.43968470
34SIK31.43785821
35MAP4K21.42375522
36AKT31.40536953
37BLK1.38947041
38ADRBK21.36512221
39MAPKAPK31.36023943
40GRK71.34407736
41NUAK11.31723062
42ERBB31.22567425
43RPS6KA51.20163515
44BCR1.16980958
45TAOK21.16190508
46MAPK151.16143687
47WNK31.13714975
48MKNK21.12681319
49TXK1.12488323
50PIM21.10949409
51ADRBK11.10600488
52TNK21.09977804
53MAPK131.07103863
54PASK1.05966263
55MKNK11.03647240
56TSSK60.99328066
57MAP3K80.98576532
58IRAK20.96592612
59DAPK10.96373473
60TAOK10.93602853
61ERN10.91250622
62NTRK30.90419301
63VRK10.89781405
64EIF2AK30.89739986
65CSNK1A1L0.89728758
66GRK10.87463854
67YES10.86161060
68AURKA0.86096818
69FLT30.86014740
70CCNB10.84489801
71FRK0.84071526
72MAP2K30.83377685
73MAP2K20.83045672
74PRKD30.82172418
75PRPF4B0.81650540
76HIPK20.81379842
77UHMK10.79448536
78TEC0.78750171
79SYK0.77278097
80CDC42BPA0.76390651
81IRAK40.74822908
82CAMKK20.74533705
83ITK0.73589168
84ABL20.70487090
85BUB10.69961520
86MAP3K110.69871123
87RIPK40.69039168
88DYRK20.67895163
89PLK20.67032972
90PRKCQ0.66358387
91CAMK2B0.64232138
92PRKCG0.62378332
93JAK30.61797949
94CSNK1G20.61246345
95ZAP700.60918431
96IRAK30.59689933
97TRIB30.59082770
98MARK10.58668774
99PRKCE0.58433448
100GRK50.58332802
101ATR0.58037352
102MAPKAPK50.57653203
103MAP3K30.57334058
104CHUK0.55268358
105CDC70.54838080
106CAMK10.54430274
107MAPK110.54271415
108IKBKB0.53509490
109LYN0.52038995
110CSNK1G10.51173815
111SGK2230.50994167
112SGK4940.50994167
113SIK10.50060275
114CDK80.48920074
115LCK0.48842811
116PRKAA10.48757041
117RAF10.48643452
118MAP2K40.48620135
119PRKCI0.47938276
120SGK20.47153755
121CAMK2A0.46880740
122ALK0.46768566
123MINK10.46753981
124TAOK30.46162978
125OXSR10.45431617
126RPS6KA40.45330921
127CAMK2D0.45284893
128TESK10.44684457
129MAP3K40.43061210
130DAPK20.41664239
131KIT0.40177500
132MAP3K140.40001162
133FES0.39960583
134MAP4K10.39859700
135NTRK20.38594404
136PRKD20.37719328
137OBSCN0.37611092
138CDK70.37144757
139PRKACA0.36265194
140MAPK30.36242612
141CSNK2A10.36057883
142CHEK20.34494361
143INSRR0.34197132
144CDK40.33650861
145TIE10.32782210
146CDK50.32046092
147TLK10.31918504
148PAK60.31535600
149MARK30.31403025
150PKN10.31000134
151MAP2K60.30942688
152CSF1R0.30410530
153CSNK2A20.30114704
154CAMKK10.29989046
155CAMK2G0.29254714
156FGR0.29214383
157CSNK1G30.29172377
158WNK40.29031142
159MAP3K130.28929276
160BTK0.28912968
161DYRK30.27573966

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.89560852
2Oxidative phosphorylation_Homo sapiens_hsa001904.39752089
3Parkinsons disease_Homo sapiens_hsa050123.87034440
4Proteasome_Homo sapiens_hsa030503.27146875
5Ribosome_Homo sapiens_hsa030102.93808035
6Alzheimers disease_Homo sapiens_hsa050102.74915920
7Huntingtons disease_Homo sapiens_hsa050162.56416347
8Vibrio cholerae infection_Homo sapiens_hsa051102.35525498
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22239047
10RNA polymerase_Homo sapiens_hsa030201.98382410
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88621051
12Phototransduction_Homo sapiens_hsa047441.86511252
13Collecting duct acid secretion_Homo sapiens_hsa049661.80308253
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.77215856
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.64915134
16Synaptic vesicle cycle_Homo sapiens_hsa047211.58796443
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46674712
18Nicotine addiction_Homo sapiens_hsa050331.44658851
19N-Glycan biosynthesis_Homo sapiens_hsa005101.43907928
20Allograft rejection_Homo sapiens_hsa053301.43875586
21Selenocompound metabolism_Homo sapiens_hsa004501.39970186
22Cardiac muscle contraction_Homo sapiens_hsa042601.39746685
23Pyrimidine metabolism_Homo sapiens_hsa002401.39222050
24Peroxisome_Homo sapiens_hsa041461.38022600
25Spliceosome_Homo sapiens_hsa030401.36755050
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36456105
27Sulfur relay system_Homo sapiens_hsa041221.35205868
28Type I diabetes mellitus_Homo sapiens_hsa049401.34854126
29Systemic lupus erythematosus_Homo sapiens_hsa053221.33065637
30Other glycan degradation_Homo sapiens_hsa005111.29695605
31Olfactory transduction_Homo sapiens_hsa047401.29529269
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22942823
33Taste transduction_Homo sapiens_hsa047421.22000064
34GABAergic synapse_Homo sapiens_hsa047271.21728415
35Folate biosynthesis_Homo sapiens_hsa007901.16811402
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14357897
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14202571
38Serotonergic synapse_Homo sapiens_hsa047261.11242879
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.10970884
40Purine metabolism_Homo sapiens_hsa002301.10838335
41Lysosome_Homo sapiens_hsa041421.08058567
42Morphine addiction_Homo sapiens_hsa050321.05269309
43Antigen processing and presentation_Homo sapiens_hsa046121.04245894
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.01777419
45Asthma_Homo sapiens_hsa053101.01740403
46Circadian entrainment_Homo sapiens_hsa047131.00918176
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99982179
48Insulin secretion_Homo sapiens_hsa049110.99791640
49Autoimmune thyroid disease_Homo sapiens_hsa053200.99311382
50Fatty acid elongation_Homo sapiens_hsa000620.98218259
51Sulfur metabolism_Homo sapiens_hsa009200.96042846
52Arachidonic acid metabolism_Homo sapiens_hsa005900.91689147
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91124461
54Leishmaniasis_Homo sapiens_hsa051400.90641247
55Primary immunodeficiency_Homo sapiens_hsa053400.86360113
56Regulation of autophagy_Homo sapiens_hsa041400.86289648
57Basal transcription factors_Homo sapiens_hsa030220.84857936
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84266328
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82447645
60Rheumatoid arthritis_Homo sapiens_hsa053230.82338143
61Galactose metabolism_Homo sapiens_hsa000520.77336105
62Dopaminergic synapse_Homo sapiens_hsa047280.76158906
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75937671
64Amphetamine addiction_Homo sapiens_hsa050310.74990877
65Base excision repair_Homo sapiens_hsa034100.71770985
66Butanoate metabolism_Homo sapiens_hsa006500.70573166
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70062242
68Glutamatergic synapse_Homo sapiens_hsa047240.69528454
69DNA replication_Homo sapiens_hsa030300.68263903
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68063471
71Epstein-Barr virus infection_Homo sapiens_hsa051690.67686760
72Cocaine addiction_Homo sapiens_hsa050300.67408676
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66883123
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66725548
75Linoleic acid metabolism_Homo sapiens_hsa005910.65600307
76One carbon pool by folate_Homo sapiens_hsa006700.65087898
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64783840
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63583981
79Shigellosis_Homo sapiens_hsa051310.63467186
80B cell receptor signaling pathway_Homo sapiens_hsa046620.61619332
81Phagosome_Homo sapiens_hsa041450.59332830
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58879882
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58818829
84Homologous recombination_Homo sapiens_hsa034400.58335745
85Metabolic pathways_Homo sapiens_hsa011000.58304116
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.57249465
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56380575
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54228193
89Fructose and mannose metabolism_Homo sapiens_hsa000510.53991783
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53061053
91Fanconi anemia pathway_Homo sapiens_hsa034600.52500938
92Alcoholism_Homo sapiens_hsa050340.52306565
93Ovarian steroidogenesis_Homo sapiens_hsa049130.52167202
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52015502
95RNA degradation_Homo sapiens_hsa030180.51521045
96Viral myocarditis_Homo sapiens_hsa054160.51069125
97Cholinergic synapse_Homo sapiens_hsa047250.49541492
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48926419
99Sphingolipid metabolism_Homo sapiens_hsa006000.48894019
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48750612
101Measles_Homo sapiens_hsa051620.48396905
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48216616
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47166988
104Salmonella infection_Homo sapiens_hsa051320.46657740
105Tuberculosis_Homo sapiens_hsa051520.46473449
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46347744
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45520971
108Nucleotide excision repair_Homo sapiens_hsa034200.43750043
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43020723
110T cell receptor signaling pathway_Homo sapiens_hsa046600.41846346
111Mismatch repair_Homo sapiens_hsa034300.41663086
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41502766
113Glutathione metabolism_Homo sapiens_hsa004800.39944625
114Long-term potentiation_Homo sapiens_hsa047200.39616913
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38486195
116Apoptosis_Homo sapiens_hsa042100.37612664
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37503396
118Calcium signaling pathway_Homo sapiens_hsa040200.37326440
119Acute myeloid leukemia_Homo sapiens_hsa052210.36290265
120ABC transporters_Homo sapiens_hsa020100.34902121
121RNA transport_Homo sapiens_hsa030130.34409336
122Circadian rhythm_Homo sapiens_hsa047100.34036741
123Graft-versus-host disease_Homo sapiens_hsa053320.33952455
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.32885762
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32175470
126Herpes simplex infection_Homo sapiens_hsa051680.31671853
127Hematopoietic cell lineage_Homo sapiens_hsa046400.31324789
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30465545
129Non-homologous end-joining_Homo sapiens_hsa034500.30198051
130Long-term depression_Homo sapiens_hsa047300.29693991
131Ether lipid metabolism_Homo sapiens_hsa005650.29150702
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27791989
133Viral carcinogenesis_Homo sapiens_hsa052030.26772319
134Hepatitis C_Homo sapiens_hsa051600.25519697
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23333337
136Salivary secretion_Homo sapiens_hsa049700.19181119
137Gap junction_Homo sapiens_hsa045400.18825604
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17865082

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