ALKBH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.78397533
2ATP synthesis coupled proton transport (GO:0015986)7.19433461
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.19433461
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.87727344
5respiratory electron transport chain (GO:0022904)6.47297668
6electron transport chain (GO:0022900)6.30989620
7DNA deamination (GO:0045006)6.15391788
8viral transcription (GO:0019083)5.76385516
9translational termination (GO:0006415)5.58110953
10oxidative phosphorylation (GO:0006119)5.37388656
11ribosomal small subunit biogenesis (GO:0042274)5.21784661
12regulation of mitochondrial translation (GO:0070129)5.13531161
13ribosomal small subunit assembly (GO:0000028)5.06971217
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.02031354
15ribosomal large subunit biogenesis (GO:0042273)4.99373563
16cotranslational protein targeting to membrane (GO:0006613)4.98324962
17protein targeting to ER (GO:0045047)4.92446953
18translational elongation (GO:0006414)4.91082501
19protein complex biogenesis (GO:0070271)4.85395090
20proteasome assembly (GO:0043248)4.74897845
21protein localization to endoplasmic reticulum (GO:0070972)4.72016960
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67725627
23mitochondrial respiratory chain complex assembly (GO:0033108)4.64475075
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54270387
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.54270387
26NADH dehydrogenase complex assembly (GO:0010257)4.54270387
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.50050417
28chaperone-mediated protein transport (GO:0072321)4.49709044
29transcription elongation from RNA polymerase III promoter (GO:0006385)4.41486798
30termination of RNA polymerase III transcription (GO:0006386)4.41486798
31viral life cycle (GO:0019058)4.40829099
32translational initiation (GO:0006413)4.38814079
33translation (GO:0006412)4.37618806
34cellular protein complex disassembly (GO:0043624)4.37113076
35maturation of SSU-rRNA (GO:0030490)4.34780589
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.31073810
37ubiquinone biosynthetic process (GO:0006744)4.29800286
38quinone biosynthetic process (GO:1901663)4.29800286
39base-excision repair, AP site formation (GO:0006285)4.12755844
40respiratory chain complex IV assembly (GO:0008535)4.07654208
41metallo-sulfur cluster assembly (GO:0031163)4.07035662
42iron-sulfur cluster assembly (GO:0016226)4.07035662
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.06096126
44GTP biosynthetic process (GO:0006183)4.01891724
45protein targeting to mitochondrion (GO:0006626)4.01385042
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.95260101
47ATP biosynthetic process (GO:0006754)3.93365351
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.93018315
49establishment of protein localization to mitochondrion (GO:0072655)3.91478988
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.90198505
51inner mitochondrial membrane organization (GO:0007007)3.86099182
52cellular component biogenesis (GO:0044085)3.80035564
53L-methionine salvage (GO:0071267)3.80034398
54L-methionine biosynthetic process (GO:0071265)3.80034398
55amino acid salvage (GO:0043102)3.80034398
56purine deoxyribonucleotide catabolic process (GO:0009155)3.78999622
57DNA damage response, detection of DNA damage (GO:0042769)3.78976313
58ubiquinone metabolic process (GO:0006743)3.77314673
59spliceosomal snRNP assembly (GO:0000387)3.76894858
60protein complex disassembly (GO:0043241)3.76012565
61pseudouridine synthesis (GO:0001522)3.75592216
62rRNA modification (GO:0000154)3.73470049
63ribonucleoprotein complex biogenesis (GO:0022613)3.73053389
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71957990
65viral protein processing (GO:0019082)3.69593056
66protein localization to mitochondrion (GO:0070585)3.67851058
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67139029
68macromolecular complex disassembly (GO:0032984)3.65334802
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.62683923
70deoxyribonucleotide catabolic process (GO:0009264)3.61511818
717-methylguanosine mRNA capping (GO:0006370)3.60552898
72RNA capping (GO:0036260)3.59222137
737-methylguanosine RNA capping (GO:0009452)3.59222137
74UTP biosynthetic process (GO:0006228)3.59009572
75negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.58141576
76aerobic respiration (GO:0009060)3.54398410
77cytochrome complex assembly (GO:0017004)3.52316235
78guanosine-containing compound biosynthetic process (GO:1901070)3.49617517
79spliceosomal complex assembly (GO:0000245)3.47422774
80aldehyde catabolic process (GO:0046185)3.47056509
81regulation of cellular amino acid metabolic process (GO:0006521)3.45179274
82hydrogen ion transmembrane transport (GO:1902600)3.42174575
83negative regulation of ligase activity (GO:0051352)3.41603613
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41603613
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40985639
86cullin deneddylation (GO:0010388)3.36743535
87rRNA processing (GO:0006364)3.33372507
88GDP-mannose metabolic process (GO:0019673)3.33090470
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31203718
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29674847
91telomere maintenance via semi-conservative replication (GO:0032201)3.28816542
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27976282
93deoxyribose phosphate catabolic process (GO:0046386)3.27708004
94protein deneddylation (GO:0000338)3.26003901
95pyrimidine nucleotide catabolic process (GO:0006244)3.25497922
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22538150
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22411116
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22135216
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22135216
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20776389
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20776389
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20776389
103nucleoside triphosphate biosynthetic process (GO:0009142)3.19648139
104transcription-coupled nucleotide-excision repair (GO:0006283)3.19645248
105protein targeting to membrane (GO:0006612)3.19405143
106UTP metabolic process (GO:0046051)3.17959767
107CTP metabolic process (GO:0046036)3.16872915
108CTP biosynthetic process (GO:0006241)3.16872915
109signal transduction involved in DNA damage checkpoint (GO:0072422)3.16614433
110signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16614433
111glyoxylate metabolic process (GO:0046487)2.98896309
112NADH metabolic process (GO:0006734)2.98535327
113protein maturation by protein folding (GO:0022417)2.83983259
114establishment of protein localization to membrane (GO:0090150)2.83678960
115nuclear-transcribed mRNA catabolic process (GO:0000956)2.83469152
116negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83282361
117protein insertion into membrane (GO:0051205)2.82802707
118protein neddylation (GO:0045116)2.80335445
119positive regulation of mitochondrial fission (GO:0090141)2.77723658
120proton transport (GO:0015992)2.76229863
121regulation of skeletal muscle contraction (GO:0014819)2.73659482
122hydrogen transport (GO:0006818)2.73449430
123positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.68808784
124mitochondrial calcium ion transport (GO:0006851)2.68490341
125heme metabolic process (GO:0042168)2.68307964
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66490997
127protein targeting (GO:0006605)2.66439427
128mRNA catabolic process (GO:0006402)2.66053651
1292-deoxyribonucleotide metabolic process (GO:0009394)2.64432695
130mitochondrial transport (GO:0006839)2.64317841
131virion assembly (GO:0019068)2.63838869
132purine deoxyribonucleotide metabolic process (GO:0009151)2.62760324
133hydrogen peroxide catabolic process (GO:0042744)2.62133179
134nucleotide salvage (GO:0043173)2.61755568
135heme biosynthetic process (GO:0006783)2.59130330
136positive regulation of prostaglandin secretion (GO:0032308)2.52787638
137pyrimidine nucleobase catabolic process (GO:0006208)2.51993182
138creatine metabolic process (GO:0006600)2.51980456
139negative regulation of DNA-templated transcription, elongation (GO:0032785)2.51475255
140peroxisome fission (GO:0016559)2.50889437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67087202
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34336711
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.29590376
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.18375562
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.07191192
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00063543
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.87328308
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.77921031
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.60637471
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.56475932
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.46895454
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23160574
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.11746439
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02531723
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91647116
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83281273
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73240676
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72129352
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71652862
20VDR_23849224_ChIP-Seq_CD4+_Human2.60312290
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.58194720
22DCP1A_22483619_ChIP-Seq_HELA_Human2.55476463
23E2F7_22180533_ChIP-Seq_HELA_Human2.54972454
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.54315852
25* XRN2_22483619_ChIP-Seq_HELA_Human2.49594221
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.45861958
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42332728
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33793777
29FOXP3_21729870_ChIP-Seq_TREG_Human2.19086813
30LXR_22292898_ChIP-Seq_THP-1_Human2.11629459
31BCL6_27268052_Chip-Seq_Bcells_Human2.09783469
32TTF2_22483619_ChIP-Seq_HELA_Human2.08161555
33GABP_19822575_ChIP-Seq_HepG2_Human2.06274066
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04929257
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04798710
36VDR_21846776_ChIP-Seq_THP-1_Human2.02982122
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01240718
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98817331
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.94850656
40P68_20966046_ChIP-Seq_HELA_Human1.92685018
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.92103922
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85746831
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84552741
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81365475
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78179290
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77523715
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72127901
48EZH2_22144423_ChIP-Seq_EOC_Human1.71690038
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70575547
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.69326593
51CTCF_27219007_Chip-Seq_Bcells_Human1.67834994
52BCOR_27268052_Chip-Seq_Bcells_Human1.67550225
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64265602
54E2F1_20622854_ChIP-Seq_HELA_Human1.62084804
55PHF8_20622854_ChIP-Seq_HELA_Human1.59500887
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58061362
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56334551
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.54742281
59CTCF_20526341_ChIP-Seq_ESCs_Human1.52755407
60SA1_27219007_Chip-Seq_Bcells_Human1.52198059
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.51894732
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51839419
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51661823
64ELK1_19687146_ChIP-ChIP_HELA_Human1.51073699
65CIITA_25753668_ChIP-Seq_RAJI_Human1.51001986
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.51001497
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50154165
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48184320
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46332156
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45186002
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44311958
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.43915475
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42849449
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42729804
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41882112
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40020876
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39460353
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37213900
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36377069
80CTCF_21964334_Chip-Seq_Bcells_Human1.34078000
81* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31271594
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27534384
83* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27438954
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26321980
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26242650
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.22504213
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21136261
88MYC_18940864_ChIP-ChIP_HL60_Human1.20649246
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19835863
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19620458
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19146917
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18569099
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17228543
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15096305
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11477021
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10425545
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10387668
98P300_27268052_Chip-Seq_Bcells_Human1.09743642
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09590306
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.09367565
101SMC4_20622854_ChIP-Seq_HELA_Human1.08938682
102NANOG_20526341_ChIP-Seq_ESCs_Human1.08521752
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08394072
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08044863
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07775149
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07188575
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06841928
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.05735873
109SPI1_20517297_ChIP-Seq_HL60_Human1.05133603
110KDM5A_27292631_Chip-Seq_BREAST_Human1.04938335
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04710743
112ERA_21632823_ChIP-Seq_H3396_Human1.04579477
113MAF_26560356_Chip-Seq_TH2_Human1.03585720
114STAT1_20625510_ChIP-Seq_HELA_Human1.02973824
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02230258
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02171138
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01836112
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01660129
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99744428
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98387889
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98230735
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95654782
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95602130
124* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94068870
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93054446
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92585983
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90755525
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89139841
129* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88906569
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.87697246
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85768661
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85317427
133* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85298488
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84033965
135ZNF263_19887448_ChIP-Seq_K562_Human0.83320581
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82394773
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82073481
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.81627595
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80286824
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79715102
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.77702154
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77171348
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.77120791
144* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76872801
145* CTCF_26484167_Chip-Seq_Bcells_Mouse0.75909987
146E2F1_21310950_ChIP-Seq_MCF-7_Human0.75500984
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75447565
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71725450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.15377974
2MP0006036_abnormal_mitochondrial_physio3.59727797
3MP0003693_abnormal_embryo_hatching3.35609698
4MP0009379_abnormal_foot_pigmentation3.17299942
5MP0004215_abnormal_myocardial_fiber2.91670021
6MP0006292_abnormal_olfactory_placode2.82034111
7MP0004084_abnormal_cardiac_muscle2.80853202
8MP0002837_dystrophic_cardiac_calcinosis2.78551452
9MP0006035_abnormal_mitochondrial_morpho2.58244406
10MP0004957_abnormal_blastocyst_morpholog2.57835563
11MP0000749_muscle_degeneration2.54102836
12MP0001529_abnormal_vocalization2.47043445
13MP0003806_abnormal_nucleotide_metabolis2.43511227
14MP0002653_abnormal_ependyma_morphology2.43427875
15MP0005330_cardiomyopathy2.24957727
16MP0000751_myopathy2.24940345
17MP0003186_abnormal_redox_activity2.07286005
18MP0004036_abnormal_muscle_relaxation2.06595465
19MP0006072_abnormal_retinal_apoptosis1.99900461
20MP0009840_abnormal_foam_cell1.99200938
21MP0002822_catalepsy1.92037241
22MP0003137_abnormal_impulse_conducting1.89037605
23MP0003718_maternal_effect1.87439163
24MP0002139_abnormal_hepatobiliary_system1.87270584
25MP0008932_abnormal_embryonic_tissue1.81032326
26MP0005423_abnormal_somatic_nervous1.80980497
27MP0008058_abnormal_DNA_repair1.78932558
28MP0005670_abnormal_white_adipose1.76820996
29MP0001905_abnormal_dopamine_level1.76566250
30MP0003123_paternal_imprinting1.73478738
31MP0010094_abnormal_chromosome_stability1.72343387
32MP0008875_abnormal_xenobiotic_pharmacok1.71198410
33MP0003011_delayed_dark_adaptation1.68994836
34MP0003077_abnormal_cell_cycle1.68359609
35MP0008789_abnormal_olfactory_epithelium1.67625035
36MP0005058_abnormal_lysosome_morphology1.66759786
37MP0003221_abnormal_cardiomyocyte_apopto1.66328423
38MP0005499_abnormal_olfactory_system1.60338957
39MP0005394_taste/olfaction_phenotype1.60338957
40MP0003111_abnormal_nucleus_morphology1.59206322
41MP0002638_abnormal_pupillary_reflex1.55774923
42MP0004142_abnormal_muscle_tone1.55235510
43MP0006276_abnormal_autonomic_nervous1.55149449
44MP0003315_abnormal_perineum_morphology1.55062957
45MP0002127_abnormal_cardiovascular_syste1.53835976
46MP0002132_abnormal_respiratory_system1.51671306
47MP0000678_abnormal_parathyroid_gland1.51155859
48MP0000750_abnormal_muscle_regeneration1.50692950
49MP0002332_abnormal_exercise_endurance1.50224920
50MP0005360_urolithiasis1.49812663
51MP0002972_abnormal_cardiac_muscle1.49289916
52MP0001986_abnormal_taste_sensitivity1.47181977
53MP0003786_premature_aging1.44781165
54MP0005266_abnormal_metabolism1.44364202
55MP0010030_abnormal_orbit_morphology1.44290923
56MP0009697_abnormal_copulation1.38914609
57MP0008057_abnormal_DNA_replication1.35850760
58MP0003136_yellow_coat_color1.28528647
59MP0000049_abnormal_middle_ear1.26664171
60MP0003879_abnormal_hair_cell1.25825336
61MP0008007_abnormal_cellular_replicative1.23317758
62MP0000343_altered_response_to1.22327348
63MP0005365_abnormal_bile_salt1.20532409
64MP0004019_abnormal_vitamin_homeostasis1.18767422
65MP0001764_abnormal_homeostasis1.16225028
66MP0000358_abnormal_cell_content/1.13426280
67MP0005385_cardiovascular_system_phenoty1.12554139
68MP0001544_abnormal_cardiovascular_syste1.12554139
69MP0001968_abnormal_touch/_nociception1.12475158
70MP0002163_abnormal_gland_morphology1.11996454
71MP0004484_altered_response_of1.11011281
72MP0008877_abnormal_DNA_methylation1.10773059
73MP0004145_abnormal_muscle_electrophysio1.10051680
74MP0005253_abnormal_eye_physiology1.08928604
75MP0005551_abnormal_eye_electrophysiolog1.08926242
76MP0005620_abnormal_muscle_contractility1.08352974
77MP0005645_abnormal_hypothalamus_physiol1.07334368
78MP0005084_abnormal_gallbladder_morpholo1.06066711
79MP0002106_abnormal_muscle_physiology1.04371694
80MP0000681_abnormal_thyroid_gland1.01962704
81MP0002160_abnormal_reproductive_system1.01030060
82MP0008260_abnormal_autophagy1.00728534
83MP0002876_abnormal_thyroid_physiology0.99847973
84MP0000372_irregular_coat_pigmentation0.99446085
85MP0000026_abnormal_inner_ear0.98256479
86MP0003878_abnormal_ear_physiology0.97730752
87MP0005377_hearing/vestibular/ear_phenot0.97730752
88MP0005379_endocrine/exocrine_gland_phen0.96940354
89MP0005535_abnormal_body_temperature0.96667559
90MP0008775_abnormal_heart_ventricle0.96244643
91MP0005085_abnormal_gallbladder_physiolo0.94679007
92MP0004147_increased_porphyrin_level0.93527832
93MP0004043_abnormal_pH_regulation0.89491968
94MP0004087_abnormal_muscle_fiber0.89319342
95MP0002269_muscular_atrophy0.88986084
96MP0001970_abnormal_pain_threshold0.88649850
97MP0009764_decreased_sensitivity_to0.87594047
98MP0009643_abnormal_urine_homeostasis0.87080931
99MP0008872_abnormal_physiological_respon0.85719137
100MP0005636_abnormal_mineral_homeostasis0.85345888
101MP0004510_myositis0.85290171
102MP0002557_abnormal_social/conspecific_i0.84762282
103MP0001663_abnormal_digestive_system0.83924780
104MP0002102_abnormal_ear_morphology0.82666309
105MP0008995_early_reproductive_senescence0.82553960
106MP0002733_abnormal_thermal_nociception0.81821372
107MP0001963_abnormal_hearing_physiology0.81325929
108MP0005410_abnormal_fertilization0.80900564
109MP0001188_hyperpigmentation0.80612510
110MP0002148_abnormal_hypersensitivity_rea0.80266908
111MP0003122_maternal_imprinting0.79588148
112MP0005376_homeostasis/metabolism_phenot0.79518418
113MP0003787_abnormal_imprinting0.79348172
114MP0004085_abnormal_heartbeat0.78490548
115MP0005332_abnormal_amino_acid0.77628932
116MP0001485_abnormal_pinna_reflex0.77453022
117MP0000747_muscle_weakness0.77070833
118MP0001502_abnormal_circadian_rhythm0.76899003
119MP0001730_embryonic_growth_arrest0.76828493
120MP0004133_heterotaxia0.76538884
121MP0003567_abnormal_fetal_cardiomyocyte0.76290779
122MP0005409_darkened_coat_color0.74260899
123MP0003656_abnormal_erythrocyte_physiolo0.74219076
124MP0003880_abnormal_central_pattern0.74088332
125MP0003941_abnormal_skin_development0.74078466
126MP0005369_muscle_phenotype0.73406965
127MP0002138_abnormal_hepatobiliary_system0.72632027
128MP0001853_heart_inflammation0.71250666
129MP0006138_congestive_heart_failure0.71087260
130MP0000313_abnormal_cell_death0.70669381
131MP0005025_abnormal_response_to0.70081977
132MP0003950_abnormal_plasma_membrane0.69430694
133MP0005389_reproductive_system_phenotype0.68215586
134MP0003121_genomic_imprinting0.67382347
135MP0001984_abnormal_olfaction0.67366631
136MP0000759_abnormal_skeletal_muscle0.67238648
137MP0005381_digestive/alimentary_phenotyp0.65639214
138MP0002272_abnormal_nervous_system0.65155543
139MP0001542_abnormal_bone_strength0.64927112
140MP0010630_abnormal_cardiac_muscle0.64506289
141MP0009785_altered_susceptibility_to0.63753435
142MP0000604_amyloidosis0.63644871
143MP0005319_abnormal_enzyme/_coenzyme0.63618832
144MP0005451_abnormal_body_composition0.62235812
145MP0008469_abnormal_protein_level0.62134928
146MP0005584_abnormal_enzyme/coenzyme_acti0.61890609
147MP0009333_abnormal_splenocyte_physiolog0.61863375
148MP0005075_abnormal_melanosome_morpholog0.61653113
149MP0000230_abnormal_systemic_arterial0.61467869
150MP0002249_abnormal_larynx_morphology0.61326072
151MP0000013_abnormal_adipose_tissue0.61282195
152MP0002210_abnormal_sex_determination0.61012071
153MP0005165_increased_susceptibility_to0.60246115

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.53261851
2Abnormal mitochondria in muscle tissue (HP:0008316)6.32446619
3Mitochondrial inheritance (HP:0001427)6.24357087
4Hepatocellular necrosis (HP:0001404)6.02723088
5Hepatic necrosis (HP:0002605)5.70142171
6Increased CSF lactate (HP:0002490)5.50291875
7Acute encephalopathy (HP:0006846)5.48982971
8Progressive macrocephaly (HP:0004481)5.48515850
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.36054753
10Decreased activity of mitochondrial respiratory chain (HP:0008972)5.36054753
11Increased hepatocellular lipid droplets (HP:0006565)5.06930266
12Increased intramyocellular lipid droplets (HP:0012240)4.82226125
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.76142411
14Lipid accumulation in hepatocytes (HP:0006561)4.71600128
15Increased muscle lipid content (HP:0009058)4.33290602
16Increased serum lactate (HP:0002151)4.31286588
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.18667324
18Abnormality of cells of the erythroid lineage (HP:0012130)4.18205400
19Lactic acidosis (HP:0003128)4.15731043
20Cerebral edema (HP:0002181)4.11368599
21Exercise intolerance (HP:0003546)4.04552204
22Abnormal number of erythroid precursors (HP:0012131)4.03241579
23Respiratory failure (HP:0002878)3.92609340
24Renal Fanconi syndrome (HP:0001994)3.85694407
253-Methylglutaconic aciduria (HP:0003535)3.82761739
26Exertional dyspnea (HP:0002875)3.41002726
27Optic disc pallor (HP:0000543)3.31914055
28Respiratory difficulties (HP:0002880)3.16191132
29CNS demyelination (HP:0007305)3.11487250
30Increased serum pyruvate (HP:0003542)3.08800579
31Abnormality of glycolysis (HP:0004366)3.08800579
32Emotional lability (HP:0000712)3.02182701
33Reticulocytopenia (HP:0001896)3.00037111
34Myopathic facies (HP:0002058)2.97802837
35Cerebral hypomyelination (HP:0006808)2.92791172
36Macrocytic anemia (HP:0001972)2.92575695
37Leukodystrophy (HP:0002415)2.89309687
38Myokymia (HP:0002411)2.80997887
39Cerebral palsy (HP:0100021)2.72676001
40Lethargy (HP:0001254)2.71310508
41Hyperglycinemia (HP:0002154)2.70967045
42Abnormality of alanine metabolism (HP:0010916)2.60625597
43Hyperalaninemia (HP:0003348)2.60625597
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60625597
45Ragged-red muscle fibers (HP:0003200)2.57031246
46Muscle fiber inclusion bodies (HP:0100299)2.56493294
47Type I transferrin isoform profile (HP:0003642)2.54562657
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53877864
49Glycosuria (HP:0003076)2.52283408
50Abnormality of urine glucose concentration (HP:0011016)2.52283408
51Pallor (HP:0000980)2.51562639
52Failure to thrive in infancy (HP:0001531)2.51281127
53Polyphagia (HP:0002591)2.50117608
54Abnormality of renal resorption (HP:0011038)2.48782955
55Nemaline bodies (HP:0003798)2.47564056
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43468977
57Aplastic anemia (HP:0001915)2.40206579
58Oral leukoplakia (HP:0002745)2.34254670
59Calf muscle hypertrophy (HP:0008981)2.33768283
60Dicarboxylic aciduria (HP:0003215)2.33417039
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33417039
62Palpitations (HP:0001962)2.32196676
63Breast hypoplasia (HP:0003187)2.26975352
64Sudden death (HP:0001699)2.26689495
65Hyperphosphaturia (HP:0003109)2.24843609
66Progressive muscle weakness (HP:0003323)2.24242403
67Unsteady gait (HP:0002317)2.21829668
68Neuroendocrine neoplasm (HP:0100634)2.18685552
69Microvesicular hepatic steatosis (HP:0001414)2.16214708
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15399723
71Muscle hypertrophy of the lower extremities (HP:0008968)2.15386235
72Rhabdomyolysis (HP:0003201)2.14550229
73Ventricular tachycardia (HP:0004756)2.05177062
74Distal arthrogryposis (HP:0005684)2.04350750
75Abnormal rod and cone electroretinograms (HP:0008323)2.03739356
76Bulbar palsy (HP:0001283)2.03403197
77Gliosis (HP:0002171)2.03289854
78Systemic lupus erythematosus (HP:0002725)2.01862722
79Birth length less than 3rd percentile (HP:0003561)1.97969410
80Poor suck (HP:0002033)1.94326394
81Pheochromocytoma (HP:0002666)1.93179814
82Hyperglycinuria (HP:0003108)1.91839290
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91520122
84Abnormal protein N-linked glycosylation (HP:0012347)1.91520122
85Abnormal protein glycosylation (HP:0012346)1.91520122
86Abnormal glycosylation (HP:0012345)1.91520122
87Myotonia (HP:0002486)1.91344897
88Myoglobinuria (HP:0002913)1.90426200
89Progressive external ophthalmoplegia (HP:0000590)1.89147353
90Abnormality of serine family amino acid metabolism (HP:0010894)1.88349162
91Abnormality of glycine metabolism (HP:0010895)1.88349162
92Exercise-induced muscle cramps (HP:0003710)1.87604987
93Aplasia/hypoplasia of the uterus (HP:0008684)1.87211682
94Secondary amenorrhea (HP:0000869)1.86766939
95Generalized aminoaciduria (HP:0002909)1.83187001
96Muscle stiffness (HP:0003552)1.82995366
97Severe visual impairment (HP:0001141)1.82690757
98Nausea (HP:0002018)1.80820500
99CNS hypomyelination (HP:0003429)1.80791925
100Mesangial abnormality (HP:0001966)1.79115808
101Vacuolated lymphocytes (HP:0001922)1.78853141
102Abnormal urine phosphate concentration (HP:0012599)1.78380784
103Oligomenorrhea (HP:0000876)1.78230152
104X-linked dominant inheritance (HP:0001423)1.77605812
105Exercise-induced myalgia (HP:0003738)1.76118230
106Dilated cardiomyopathy (HP:0001644)1.75897105
107Conjunctival hamartoma (HP:0100780)1.75108849
108Fetal akinesia sequence (HP:0001989)1.74880230
109Prolonged neonatal jaundice (HP:0006579)1.74819720
110Vomiting (HP:0002013)1.74687521
111Chronic otitis media (HP:0000389)1.74578779
112Metabolic acidosis (HP:0001942)1.73270137
113Methylmalonic aciduria (HP:0012120)1.73202581
114Microretrognathia (HP:0000308)1.72904320
115Multiple enchondromatosis (HP:0005701)1.72712994
116Pancytopenia (HP:0001876)1.72338843
117Reduced antithrombin III activity (HP:0001976)1.71966921
118Lipoatrophy (HP:0100578)1.70458459
119Rough bone trabeculation (HP:0100670)1.70309094
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70292767
121Blindness (HP:0000618)1.70105919
122Abnormality of the nasal mucosa (HP:0000433)1.68942237
123Nasal polyposis (HP:0100582)1.68764293
124Neoplasm of the adrenal gland (HP:0100631)1.68309636
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68062623
126Type 1 muscle fiber predominance (HP:0003803)1.68021621
127Abnormality of reticulocytes (HP:0004312)1.66529337
128Type 2 muscle fiber atrophy (HP:0003554)1.64649205
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.64486005
130Progressive neurologic deterioration (HP:0002344)1.64269382
131Muscle fiber atrophy (HP:0100295)1.63942430
132Prolonged QT interval (HP:0001657)1.63722237
133Abnormality of fatty-acid metabolism (HP:0004359)1.62638665
134Congenital stationary night blindness (HP:0007642)1.62149529
135Opisthotonus (HP:0002179)1.59980310
136Supraventricular tachycardia (HP:0004755)1.59618322
137Testicular atrophy (HP:0000029)1.59140582
138Ventricular fibrillation (HP:0001663)1.55726229
139Atrial fibrillation (HP:0005110)1.54434711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.04844582
2NME23.98572082
3STK163.93048884
4TLK13.50805906
5VRK23.46346054
6EIF2AK13.38825599
7WEE12.90912376
8BCKDK2.85319099
9PIM22.49432373
10NME12.34503456
11TAOK22.33468096
12INSRR2.21099544
13MYLK2.19144556
14VRK12.18546443
15SRPK11.99707411
16TESK21.95614275
17MAP2K71.91164209
18BRAF1.85212778
19MUSK1.83527335
20EIF2AK31.82496566
21ERN11.77203302
22ARAF1.71382093
23MAP3K121.68511341
24MAP4K21.66242575
25IRAK31.59402682
26DYRK31.53879094
27OBSCN1.50248984
28PBK1.49313122
29EPHB21.40948339
30ZAK1.29048674
31MAP3K111.28658857
32CDK191.26193754
33KDR1.25324399
34MAP4K11.20306910
35PRKD31.14123437
36PLK41.10493984
37MKNK11.08230306
38DYRK21.07951032
39MKNK21.07095214
40MAP3K131.06904672
41AURKA1.06456887
42PLK11.05791967
43CSNK1G21.04813637
44IRAK41.04798714
45LMTK21.03801298
46LIMK11.00515003
47PDK41.00337898
48PDK31.00337898
49DAPK31.00011446
50ILK0.99602870
51MAP2K60.97109421
52STK38L0.96467223
53TTK0.95608521
54BRSK20.93364542
55TBK10.92128142
56TSSK60.90603537
57ACVR1B0.89990754
58GRK70.88166200
59PRKD20.88012893
60CCNB10.84254089
61PINK10.83826761
62WNK40.81460069
63SIK20.81210007
64MAP3K40.79010571
65PRKCI0.78044081
66RPS6KA50.76833207
67IRAK20.76279246
68AURKB0.75444234
69MARK10.74223691
70TNK20.73663497
71PKN10.72617447
72PRKG20.71850347
73PHKG20.70799293
74PHKG10.70799293
75CSNK2A10.70685220
76CDK80.70643840
77BRSK10.68808798
78GRK50.68732241
79TIE10.68148197
80ABL20.66601493
81CAMK2D0.63278950
82RPS6KB20.62967576
83GRK60.62547461
84TAOK10.62279523
85STK390.61626532
86CSNK1A1L0.61510824
87CAMK2G0.60918721
88IRAK10.60211334
89CSNK2A20.59489995
90MAP2K40.58538391
91EIF2AK20.57538713
92IKBKB0.57360806
93NEK10.56890955
94PDK20.55677550
95MAPK130.53552718
96PLK30.53311380
97FLT30.53238272
98TNIK0.52956220
99NEK90.52736110
100STK240.52681389
101PIK3CA0.52192278
102CASK0.51939779
103RPS6KA60.51273984
104TESK10.51151755
105MAP2K20.51065220
106BMPR1B0.50505179
107CSNK1G30.48485224
108MAP3K50.47721276
109RPS6KA20.47084484
110IKBKE0.46675405
111CHEK20.45378631
112CDK11A0.44978977
113DAPK10.44915215
114EPHA40.43166804
115CDK70.42810152
116CSNK1G10.42750365
117MAPK40.41291130
118DYRK1B0.40939177
119MOS0.40563348
120WNK30.39813152
121NUAK10.39376736
122TAOK30.39319229
123PRKD10.38301786
124PASK0.38035492
125BCR0.38015836
126CDK140.37787636
127MATK0.37440656
128LRRK20.37353337
129ADRBK20.37247580
130TRIM280.37202935
131AKT20.37146000
132KIT0.36855794
133PAK10.36543932
134MAP3K10.35833097
135STK40.35708553
136PNCK0.34916225
137TEC0.34897324
138PRKCG0.34724882
139FES0.33686357
140MAPK150.33628233
141GRK10.32754911
142PRKCD0.32720658
143MARK20.32291543
144MAPKAPK30.31780500
145PRKACA0.31632419
146LYN0.31594912
147RPS6KC10.31287078
148RPS6KL10.31287078
149CAMK2B0.30874046

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.09617280
2Ribosome_Homo sapiens_hsa030105.00119233
3Parkinsons disease_Homo sapiens_hsa050124.75016138
4Proteasome_Homo sapiens_hsa030503.60043813
5RNA polymerase_Homo sapiens_hsa030203.59048219
6Huntingtons disease_Homo sapiens_hsa050163.46364044
7Alzheimers disease_Homo sapiens_hsa050103.24744201
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.88777928
9DNA replication_Homo sapiens_hsa030302.73298284
10Cardiac muscle contraction_Homo sapiens_hsa042602.60869045
11Pyrimidine metabolism_Homo sapiens_hsa002402.39084947
12Protein export_Homo sapiens_hsa030602.29640513
13Mismatch repair_Homo sapiens_hsa034302.24829625
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17726526
15Spliceosome_Homo sapiens_hsa030402.06401103
16Homologous recombination_Homo sapiens_hsa034401.94477710
17Nucleotide excision repair_Homo sapiens_hsa034201.83015965
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72790430
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65300151
20Base excision repair_Homo sapiens_hsa034101.64429910
21Sulfur relay system_Homo sapiens_hsa041221.50344828
22Purine metabolism_Homo sapiens_hsa002301.43304558
23Propanoate metabolism_Homo sapiens_hsa006401.31517168
24RNA transport_Homo sapiens_hsa030131.28493484
25Folate biosynthesis_Homo sapiens_hsa007901.28227135
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.24185132
27Carbon metabolism_Homo sapiens_hsa012001.22569670
28Basal transcription factors_Homo sapiens_hsa030221.22253591
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20403809
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15131159
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14493580
32RNA degradation_Homo sapiens_hsa030181.14154563
33Fatty acid elongation_Homo sapiens_hsa000621.12949497
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10662714
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09431599
36Pyruvate metabolism_Homo sapiens_hsa006201.05543702
37Asthma_Homo sapiens_hsa053101.04254896
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03897019
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.01860701
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99716269
41One carbon pool by folate_Homo sapiens_hsa006700.96719117
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96216783
43Chemical carcinogenesis_Homo sapiens_hsa052040.95882096
44Fanconi anemia pathway_Homo sapiens_hsa034600.93777508
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92809411
46Metabolic pathways_Homo sapiens_hsa011000.92116704
47Sulfur metabolism_Homo sapiens_hsa009200.90845123
48Pentose phosphate pathway_Homo sapiens_hsa000300.86790180
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86657259
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.85934661
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82870987
52Arginine biosynthesis_Homo sapiens_hsa002200.80182913
53Biosynthesis of amino acids_Homo sapiens_hsa012300.77185554
54Phototransduction_Homo sapiens_hsa047440.76627050
55Fructose and mannose metabolism_Homo sapiens_hsa000510.71914479
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71840987
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.70952217
58Glutathione metabolism_Homo sapiens_hsa004800.68061328
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66408120
60Allograft rejection_Homo sapiens_hsa053300.66280431
61Non-homologous end-joining_Homo sapiens_hsa034500.64111790
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64041165
63Synaptic vesicle cycle_Homo sapiens_hsa047210.63658629
64Cell cycle_Homo sapiens_hsa041100.63544235
65Butanoate metabolism_Homo sapiens_hsa006500.62953920
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62885061
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61117348
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.59575169
69Autoimmune thyroid disease_Homo sapiens_hsa053200.59074156
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58149384
71Vitamin B6 metabolism_Homo sapiens_hsa007500.57289331
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57168243
73Fatty acid degradation_Homo sapiens_hsa000710.55900525
74Galactose metabolism_Homo sapiens_hsa000520.54743841
75Arginine and proline metabolism_Homo sapiens_hsa003300.54218966
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.52793759
77Lysosome_Homo sapiens_hsa041420.51016992
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48839523
79Peroxisome_Homo sapiens_hsa041460.48475398
80Arachidonic acid metabolism_Homo sapiens_hsa005900.48264786
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.47012408
82Epstein-Barr virus infection_Homo sapiens_hsa051690.46673465
83Vitamin digestion and absorption_Homo sapiens_hsa049770.45165821
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43941834
85Rheumatoid arthritis_Homo sapiens_hsa053230.41200530
86Staphylococcus aureus infection_Homo sapiens_hsa051500.40978432
87PPAR signaling pathway_Homo sapiens_hsa033200.40845864
88Mineral absorption_Homo sapiens_hsa049780.39666917
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39634789
90Steroid biosynthesis_Homo sapiens_hsa001000.39477998
91Regulation of autophagy_Homo sapiens_hsa041400.38045874
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34862309
93Histidine metabolism_Homo sapiens_hsa003400.34582629
94Renin-angiotensin system_Homo sapiens_hsa046140.34446332
95Type I diabetes mellitus_Homo sapiens_hsa049400.34132244
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.33791903
97Systemic lupus erythematosus_Homo sapiens_hsa053220.31343957
98p53 signaling pathway_Homo sapiens_hsa041150.30135706
99Graft-versus-host disease_Homo sapiens_hsa053320.29285915
100Phenylalanine metabolism_Homo sapiens_hsa003600.26783781
101beta-Alanine metabolism_Homo sapiens_hsa004100.25904267
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25634031
103Tyrosine metabolism_Homo sapiens_hsa003500.25195453
104Linoleic acid metabolism_Homo sapiens_hsa005910.24916189
105Selenocompound metabolism_Homo sapiens_hsa004500.19944079
106Fatty acid metabolism_Homo sapiens_hsa012120.18505324
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17119590
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16477313
109mRNA surveillance pathway_Homo sapiens_hsa030150.16001344
110Other glycan degradation_Homo sapiens_hsa005110.14518855
111Collecting duct acid secretion_Homo sapiens_hsa049660.12931979
112Vibrio cholerae infection_Homo sapiens_hsa051100.10568739
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10405626
114Dilated cardiomyopathy_Homo sapiens_hsa054140.08457965
115Oocyte meiosis_Homo sapiens_hsa041140.07431648
116Alcoholism_Homo sapiens_hsa050340.07159506
117Caffeine metabolism_Homo sapiens_hsa002320.05957382
118Tryptophan metabolism_Homo sapiens_hsa003800.04800062
119N-Glycan biosynthesis_Homo sapiens_hsa005100.03861249
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02439159
121Primary immunodeficiency_Homo sapiens_hsa053400.02426287
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.01399447
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01293150
124Retinol metabolism_Homo sapiens_hsa008300.01280378
125Fat digestion and absorption_Homo sapiens_hsa049750.00941878
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0400364
127Starch and sucrose metabolism_Homo sapiens_hsa00500-0.0153661
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400-0.0079957
129Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0041507

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