ALKBH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.05658702
2nuclear pore organization (GO:0006999)6.22988460
3mitotic sister chromatid cohesion (GO:0007064)5.59382115
4ribosome assembly (GO:0042255)5.44921916
5pore complex assembly (GO:0046931)5.01158948
6protein localization to kinetochore (GO:0034501)4.84159217
7establishment of integrated proviral latency (GO:0075713)4.69986442
8mitotic metaphase plate congression (GO:0007080)4.67799144
9presynaptic membrane assembly (GO:0097105)4.56625860
10DNA unwinding involved in DNA replication (GO:0006268)4.33061924
11metaphase plate congression (GO:0051310)4.28333523
12IMP biosynthetic process (GO:0006188)4.27665898
13protein localization to chromosome, centromeric region (GO:0071459)4.25827211
14mitotic chromosome condensation (GO:0007076)4.24811611
15IMP metabolic process (GO:0046040)4.18975256
16DNA strand elongation involved in DNA replication (GO:0006271)4.17152026
17spindle checkpoint (GO:0031577)4.10954367
18mitotic spindle checkpoint (GO:0071174)4.05818387
19presynaptic membrane organization (GO:0097090)4.05047651
20sister chromatid segregation (GO:0000819)4.01435498
21chromatin remodeling at centromere (GO:0031055)4.00829669
22regulation of mitotic spindle organization (GO:0060236)4.00597230
23negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.99954760
24negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.99954760
25negative regulation of mitotic sister chromatid segregation (GO:0033048)3.99954760
26negative regulation of mitotic sister chromatid separation (GO:2000816)3.99954760
27negative regulation of sister chromatid segregation (GO:0033046)3.99954760
28DNA strand elongation (GO:0022616)3.99054170
29negative regulation of chromosome segregation (GO:0051985)3.94176404
30mitotic sister chromatid segregation (GO:0000070)3.92649364
31mitotic nuclear envelope disassembly (GO:0007077)3.91194703
32DNA replication checkpoint (GO:0000076)3.84361393
33establishment of chromosome localization (GO:0051303)3.82000318
34regulation of spindle organization (GO:0090224)3.81049573
35mitotic spindle assembly checkpoint (GO:0007094)3.76032767
36regulation of centriole replication (GO:0046599)3.75246870
37spindle assembly checkpoint (GO:0071173)3.73629410
38purine nucleobase biosynthetic process (GO:0009113)3.71634759
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71345305
40non-recombinational repair (GO:0000726)3.70198099
41double-strand break repair via nonhomologous end joining (GO:0006303)3.70198099
42nuclear envelope disassembly (GO:0051081)3.68486513
43membrane disassembly (GO:0030397)3.68486513
44regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.64026938
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.64026938
46establishment of viral latency (GO:0019043)3.62577797
47regulation of chromosome segregation (GO:0051983)3.62115446
48regulation of mitotic sister chromatid separation (GO:0010965)3.57611280
49regulation of mitotic sister chromatid segregation (GO:0033047)3.57611280
50regulation of sister chromatid segregation (GO:0033045)3.57611280
51limb bud formation (GO:0060174)3.55882607
52viral mRNA export from host cell nucleus (GO:0046784)3.55154079
53formation of translation preinitiation complex (GO:0001731)3.54566334
54histone exchange (GO:0043486)3.47934068
55amino acid activation (GO:0043038)3.44108924
56tRNA aminoacylation (GO:0043039)3.44108924
57DNA replication-independent nucleosome organization (GO:0034724)3.40820370
58DNA replication-independent nucleosome assembly (GO:0006336)3.40820370
59DNA duplex unwinding (GO:0032508)3.36841151
60tRNA aminoacylation for protein translation (GO:0006418)3.34834133
61DNA geometric change (GO:0032392)3.33539363
62mitotic recombination (GO:0006312)3.33446786
63folic acid-containing compound biosynthetic process (GO:0009396)3.31791578
64neuron cell-cell adhesion (GO:0007158)3.31347713
65RNA-dependent DNA replication (GO:0006278)3.31170425
66negative regulation of DNA recombination (GO:0045910)3.29399928
67regulation of translational termination (GO:0006449)3.27550672
68nucleobase biosynthetic process (GO:0046112)3.26536998
69regulation of helicase activity (GO:0051095)3.25558746
70mitotic G2/M transition checkpoint (GO:0044818)3.24199122
71transcription from mitochondrial promoter (GO:0006390)3.24147708
72positive regulation of protein homodimerization activity (GO:0090073)3.22547167
73negative regulation of DNA repair (GO:0045738)3.22058884
74telomere maintenance via recombination (GO:0000722)3.21886271
75attachment of spindle microtubules to kinetochore (GO:0008608)3.21173647
76cellular protein complex localization (GO:0034629)3.20960457
77telomere maintenance via telomerase (GO:0007004)3.19462483
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18701583
79protein complex localization (GO:0031503)3.17224273
80startle response (GO:0001964)3.16762286
81DNA ligation (GO:0006266)3.15477467
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14951582
83regulation of translational fidelity (GO:0006450)3.12836344
84ribosome biogenesis (GO:0042254)3.11911660
85cullin deneddylation (GO:0010388)3.11485297
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09693991
877-methylguanosine RNA capping (GO:0009452)3.06047099
88RNA capping (GO:0036260)3.06047099
89mitochondrial RNA metabolic process (GO:0000959)3.04807869
90response to X-ray (GO:0010165)3.03874868
91intraciliary transport (GO:0042073)3.03768862
92NLS-bearing protein import into nucleus (GO:0006607)3.03372092
93regulation of DNA endoreduplication (GO:0032875)3.00022262
94regulation of centrosome cycle (GO:0046605)2.99667318
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.98041024
96termination of RNA polymerase III transcription (GO:0006386)2.98041024
97regulation of sister chromatid cohesion (GO:0007063)2.96799617
987-methylguanosine mRNA capping (GO:0006370)2.96705880
99DNA conformation change (GO:0071103)2.96704399
100regulation of double-strand break repair via homologous recombination (GO:0010569)2.94811546
101telomere maintenance via telomere lengthening (GO:0010833)2.93593081
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92213542
103microtubule depolymerization (GO:0007019)2.91798724
104sister chromatid cohesion (GO:0007062)2.91106112
105negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.90102666
106proteasome assembly (GO:0043248)2.88791671
107DNA double-strand break processing (GO:0000729)2.88596593
108protein-cofactor linkage (GO:0018065)2.88268783
109postsynaptic membrane organization (GO:0001941)2.85845588
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84562391
111positive regulation of uterine smooth muscle contraction (GO:0070474)2.79645503
112centriole assembly (GO:0098534)2.77405207
113retina layer formation (GO:0010842)2.74264104
114prostate gland growth (GO:0060736)2.74064632
115dentate gyrus development (GO:0021542)2.73676211
116mannosylation (GO:0097502)2.70630845
117pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67281154
118intra-S DNA damage checkpoint (GO:0031573)2.65934433
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.61603478
120NADH dehydrogenase complex assembly (GO:0010257)2.61603478
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61603478
122protein deneddylation (GO:0000338)2.60803921
123regulation of feeding behavior (GO:0060259)2.60730455
124replication fork processing (GO:0031297)2.59538569
125cerebral cortex radially oriented cell migration (GO:0021799)2.59067165
126positive regulation of mitochondrial fission (GO:0090141)2.57158934
127negative regulation of dendrite morphogenesis (GO:0050774)2.56819984
128regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.56796160
129respiratory chain complex IV assembly (GO:0008535)2.55800090
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.54358491
131long-chain fatty acid biosynthetic process (GO:0042759)2.54247732
132lymphoid progenitor cell differentiation (GO:0002320)2.53788644
133nonmotile primary cilium assembly (GO:0035058)2.53602267
134GTP biosynthetic process (GO:0006183)2.53385624
1352-deoxyribonucleotide biosynthetic process (GO:0009265)2.52262886
136deoxyribose phosphate biosynthetic process (GO:0046385)2.52262886
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.51558072
138nucleotide transmembrane transport (GO:1901679)2.50826555
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.50353904
140DNA strand renaturation (GO:0000733)2.50334304
141protein complex biogenesis (GO:0070271)2.50163977
142centriole replication (GO:0007099)2.48600047
143DNA topological change (GO:0006265)2.48516984
144regulation of pigment cell differentiation (GO:0050932)2.46346725
145DNA damage response, detection of DNA damage (GO:0042769)2.45126922
146kinetochore organization (GO:0051383)2.44708898
147deoxyribonucleotide biosynthetic process (GO:0009263)2.40610914
148DNA catabolic process, exonucleolytic (GO:0000738)2.40105943
149transcription-coupled nucleotide-excision repair (GO:0006283)2.39605957
150DNA replication initiation (GO:0006270)2.38030681
151negative regulation of neurotransmitter transport (GO:0051589)2.35904301
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34967079
153pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.34777046
154positive regulation of action potential (GO:0045760)2.34654709
155inner ear receptor stereocilium organization (GO:0060122)2.34286316
156mesenchymal cell differentiation involved in kidney development (GO:0072161)2.33927386
157mesenchymal cell differentiation involved in renal system development (GO:2001012)2.33927386
158opioid receptor signaling pathway (GO:0038003)2.33604751
159regulation of mitotic spindle checkpoint (GO:1903504)2.33080675
160regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.33080675
161regulation of mRNA splicing, via spliceosome (GO:0048024)2.32764347
162kinetochore assembly (GO:0051382)2.31904166
163histone H3-K4 trimethylation (GO:0080182)2.31426746
164negative regulation of neurotransmitter secretion (GO:0046929)2.31064421
165CTP biosynthetic process (GO:0006241)2.29590229
166CTP metabolic process (GO:0046036)2.29590229
167negative regulation of dendrite development (GO:2000171)2.28311641
168dopamine transport (GO:0015872)2.28302760
169CENP-A containing nucleosome assembly (GO:0034080)2.27451892
170cytochrome complex assembly (GO:0017004)2.26726891
171positive regulation of synapse assembly (GO:0051965)2.26349255
172nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25855597
173deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.25599144
174protein K6-linked ubiquitination (GO:0085020)2.25050890
175protein neddylation (GO:0045116)2.24969646
176histone H2A acetylation (GO:0043968)2.24763731
177exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24023355
178negative regulation of myoblast differentiation (GO:0045662)2.23979240
179positive regulation of DNA-dependent DNA replication (GO:2000105)2.23867162
180termination of RNA polymerase I transcription (GO:0006363)2.23713419
181rRNA methylation (GO:0031167)2.22572518
182microtubule polymerization or depolymerization (GO:0031109)2.21589586
183preassembly of GPI anchor in ER membrane (GO:0016254)2.21528960
184mRNA splice site selection (GO:0006376)2.21028903
185guanosine-containing compound biosynthetic process (GO:1901070)2.19324247
186nucleotide-excision repair, DNA gap filling (GO:0006297)2.19166985
187motile cilium assembly (GO:0044458)2.19072997
188telomere maintenance via semi-conservative replication (GO:0032201)2.18660993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.91351332
2GBX2_23144817_ChIP-Seq_PC3_Human3.82122471
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.40184134
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14899932
5E2F7_22180533_ChIP-Seq_HELA_Human2.90318647
6EZH2_22144423_ChIP-Seq_EOC_Human2.89744880
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.88255316
8TAF15_26573619_Chip-Seq_HEK293_Human2.70667812
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70356700
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68357780
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60477931
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59388664
13AR_21909140_ChIP-Seq_LNCAP_Human2.50339621
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45067042
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39670607
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39141652
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38375766
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37790316
19FUS_26573619_Chip-Seq_HEK293_Human2.37204456
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32653886
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23726519
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21620746
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.17539951
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.14955993
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11755841
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.11341346
27EWS_26573619_Chip-Seq_HEK293_Human2.07702715
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.03512193
29DCP1A_22483619_ChIP-Seq_HELA_Human2.00166274
30VDR_23849224_ChIP-Seq_CD4+_Human1.99280621
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98996174
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98201094
33IGF1R_20145208_ChIP-Seq_DFB_Human1.94571768
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89249850
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89000035
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88787980
37P300_19829295_ChIP-Seq_ESCs_Human1.83538866
38FOXP3_21729870_ChIP-Seq_TREG_Human1.83226113
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81058948
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78467169
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75750496
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73212578
43IRF1_19129219_ChIP-ChIP_H3396_Human1.72611110
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70407257
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.68766802
46AR_21572438_ChIP-Seq_LNCaP_Human1.66718887
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66493572
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.64472888
49* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64426323
50ER_23166858_ChIP-Seq_MCF-7_Human1.63361160
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61860686
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60093481
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60007933
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59545957
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57179062
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56672815
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55557309
58TTF2_22483619_ChIP-Seq_HELA_Human1.54950905
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54105792
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.53524536
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53392179
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53378898
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53032629
64RNF2_27304074_Chip-Seq_NSC_Mouse1.52997743
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51546865
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.50479448
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.50078074
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.47671068
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.47550890
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47345417
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45912461
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45901834
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44526147
74P53_22387025_ChIP-Seq_ESCs_Mouse1.42963208
75SMAD4_21799915_ChIP-Seq_A2780_Human1.42635112
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42379283
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42102992
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41861768
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.41837596
80GABP_19822575_ChIP-Seq_HepG2_Human1.41352985
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39162231
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38851845
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37852442
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37591769
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37075563
86* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36956877
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.35393246
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.35364907
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34856402
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34374541
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.34206102
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.33829251
93* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32960539
94TFEB_21752829_ChIP-Seq_HELA_Human1.32682577
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.31288246
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.31279101
97P300_18555785_Chip-Seq_ESCs_Mouse1.31059803
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31051707
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30404826
100* ELK1_19687146_ChIP-ChIP_HELA_Human1.29945988
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28216147
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.27367527
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27347552
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.26467101
105CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26397110
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26036900
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25141176
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24913938
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24756553
110XRN2_22483619_ChIP-Seq_HELA_Human1.23200935
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.20303581
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.20282034
113SOX9_26525672_Chip-Seq_HEART_Mouse1.19296087
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18972196
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.17579830
116* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16061877
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.14919763
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14496604
119JUN_21703547_ChIP-Seq_K562_Human1.13668193
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.13639343
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13628230
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12966271
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11116719
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11066371
125MYC_18940864_ChIP-ChIP_HL60_Human1.11009134
126* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10851723
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10768178
128ZFX_18555785_Chip-Seq_ESCs_Mouse1.10235460
129* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08751254
130* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07797335
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07228256
132TCF4_23295773_ChIP-Seq_U87_Human1.07206111
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07176127
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06934952
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06166852
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.05320845
137NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05260157
138PU1_27457419_Chip-Seq_LIVER_Mouse1.04977725
139SOX2_16153702_ChIP-ChIP_HESCs_Human1.04157188
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03632086
141STAT3_23295773_ChIP-Seq_U87_Human1.03085190
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02868750
143* KDM5A_27292631_Chip-Seq_BREAST_Human1.02398930
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97230132
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97110932
146* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96368242
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.92892574
148CIITA_25753668_ChIP-Seq_RAJI_Human0.92595852
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92582611
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92343183
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91722812
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90288642
153CHD1_26751641_Chip-Seq_LNCaP_Human0.84983388
154HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84727493
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83103313
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79659741
157GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77289848
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76281459
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75753982
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.70962427
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70934286
162ZNF274_21170338_ChIP-Seq_K562_Hela0.70881029
163BRD4_25478319_ChIP-Seq_HGPS_Human0.69969596
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69860552
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.69370462
166TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69289385
167CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68764400
168YY1_21170310_ChIP-Seq_MESCs_Mouse0.68074270
169EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.67381876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.49560050
2MP0001188_hyperpigmentation4.26222047
3MP0004957_abnormal_blastocyst_morpholog3.95472327
4MP0003880_abnormal_central_pattern3.31489544
5MP0008057_abnormal_DNA_replication2.95313637
6MP0003787_abnormal_imprinting2.94764974
7MP0006292_abnormal_olfactory_placode2.83504109
8MP0004147_increased_porphyrin_level2.72423763
9MP0003806_abnormal_nucleotide_metabolis2.71779974
10MP0000015_abnormal_ear_pigmentation2.69617523
11MP0003221_abnormal_cardiomyocyte_apopto2.45738234
12MP0008058_abnormal_DNA_repair2.27201364
13MP0010352_gastrointestinal_tract_polyps2.23599254
14MP0000350_abnormal_cell_proliferation2.14798059
15MP0003136_yellow_coat_color2.14342422
16MP0001529_abnormal_vocalization2.13425416
17MP0001730_embryonic_growth_arrest2.11782000
18MP0002877_abnormal_melanocyte_morpholog2.10999209
19MP0003121_genomic_imprinting2.07968794
20MP0004233_abnormal_muscle_weight2.06569405
21MP0001984_abnormal_olfaction2.03581260
22MP0000566_synostosis1.94183073
23MP0005171_absent_coat_pigmentation1.87831181
24MP0005646_abnormal_pituitary_gland1.87292815
25MP0009379_abnormal_foot_pigmentation1.82009152
26MP0005409_darkened_coat_color1.78619597
27MP0010094_abnormal_chromosome_stability1.75983508
28MP0000778_abnormal_nervous_system1.74905577
29MP0001672_abnormal_embryogenesis/_devel1.74308175
30MP0005380_embryogenesis_phenotype1.74308175
31MP0003122_maternal_imprinting1.74198864
32MP0008789_abnormal_olfactory_epithelium1.74048158
33MP0001697_abnormal_embryo_size1.72567246
34MP0009745_abnormal_behavioral_response1.70308011
35MP0001905_abnormal_dopamine_level1.66378570
36MP0005499_abnormal_olfactory_system1.65758879
37MP0005394_taste/olfaction_phenotype1.65758879
38MP0002102_abnormal_ear_morphology1.65286487
39MP0002938_white_spotting1.64539472
40MP0001486_abnormal_startle_reflex1.59329928
41MP0003984_embryonic_growth_retardation1.57899150
42MP0008877_abnormal_DNA_methylation1.53098463
43MP0002088_abnormal_embryonic_growth/wei1.53082879
44MP0002080_prenatal_lethality1.51356908
45MP0005423_abnormal_somatic_nervous1.50449535
46MP0002084_abnormal_developmental_patter1.50285781
47MP0003567_abnormal_fetal_cardiomyocyte1.49104649
48MP0005408_hypopigmentation1.47540135
49MP0000358_abnormal_cell_content/1.46647634
50MP0009672_abnormal_birth_weight1.45973552
51MP0001986_abnormal_taste_sensitivity1.43849920
52MP0006035_abnormal_mitochondrial_morpho1.43560612
53MP0002572_abnormal_emotion/affect_behav1.41986535
54MP0002269_muscular_atrophy1.41788753
55MP0002095_abnormal_skin_pigmentation1.41394430
56MP0003950_abnormal_plasma_membrane1.40649720
57MP0001968_abnormal_touch/_nociception1.39363910
58MP0003635_abnormal_synaptic_transmissio1.39235343
59MP0006276_abnormal_autonomic_nervous1.38101593
60MP0002085_abnormal_embryonic_tissue1.37969701
61MP0002735_abnormal_chemical_nociception1.37261204
62MP0000372_irregular_coat_pigmentation1.36934414
63MP0005645_abnormal_hypothalamus_physiol1.36264565
64MP0009046_muscle_twitch1.36016294
65MP0002009_preneoplasia1.35744445
66MP0002063_abnormal_learning/memory/cond1.35506930
67MP0005075_abnormal_melanosome_morpholog1.35033835
68MP0002272_abnormal_nervous_system1.31985148
69MP0001293_anophthalmia1.31226235
70MP0004197_abnormal_fetal_growth/weight/1.30696841
71MP0002064_seizures1.29488728
72MP0000049_abnormal_middle_ear1.28781370
73MP0005174_abnormal_tail_pigmentation1.28575639
74MP0002086_abnormal_extraembryonic_tissu1.27486345
75MP0000631_abnormal_neuroendocrine_gland1.27244000
76MP0000313_abnormal_cell_death1.25413193
77MP0002736_abnormal_nociception_after1.24313390
78MP0004808_abnormal_hematopoietic_stem1.23301986
79MP0010234_abnormal_vibrissa_follicle1.23218331
80MP0002734_abnormal_mechanical_nocicepti1.23079572
81MP0000749_muscle_degeneration1.21809315
82MP0009703_decreased_birth_body1.21545278
83MP0001299_abnormal_eye_distance/1.20393694
84MP0009697_abnormal_copulation1.20347013
85MP0002751_abnormal_autonomic_nervous1.19821484
86MP0004142_abnormal_muscle_tone1.19733978
87MP0010307_abnormal_tumor_latency1.18493102
88MP0000026_abnormal_inner_ear1.16527202
89MP0002697_abnormal_eye_size1.15730157
90MP0003123_paternal_imprinting1.15236441
91MP0004924_abnormal_behavior1.15041355
92MP0005386_behavior/neurological_phenoty1.15041355
93MP0004215_abnormal_myocardial_fiber1.12915325
94MP0000569_abnormal_digit_pigmentation1.11489454
95MP0006036_abnormal_mitochondrial_physio1.11144266
96MP0001963_abnormal_hearing_physiology1.11092842
97MP0002638_abnormal_pupillary_reflex1.10836311
98MP0005551_abnormal_eye_electrophysiolog1.10556987
99MP0002067_abnormal_sensory_capabilities1.10353508
100MP0002557_abnormal_social/conspecific_i1.08669928
101MP0002396_abnormal_hematopoietic_system1.08468675
102MP0002160_abnormal_reproductive_system1.08093515
103MP0002876_abnormal_thyroid_physiology1.08073960
104MP0002184_abnormal_innervation1.06172117
105MP0003077_abnormal_cell_cycle1.03471760
106MP0004270_analgesia1.02578959
107MP0003786_premature_aging1.02367437
108MP0001177_atelectasis1.02079634
109MP0004134_abnormal_chest_morphology1.01939691
110MP0002177_abnormal_outer_ear1.01672386
111MP0001915_intracranial_hemorrhage1.01514643
112MP0004859_abnormal_synaptic_plasticity1.01478909
113MP0005384_cellular_phenotype0.99967212
114MP0003890_abnormal_embryonic-extraembry0.96482064
115MP0001727_abnormal_embryo_implantation0.95517475
116MP0004742_abnormal_vestibular_system0.95322034
117MP0003938_abnormal_ear_development0.94587787
118MP0003941_abnormal_skin_development0.94390993
119MP0001286_abnormal_eye_development0.94312293
120MP0003111_abnormal_nucleus_morphology0.90585422
121MP0005621_abnormal_cell_physiology0.90198647
122MP0002019_abnormal_tumor_incidence0.88827368
123MP0004381_abnormal_hair_follicle0.88795145
124MP0002163_abnormal_gland_morphology0.87884056
125MP0003937_abnormal_limbs/digits/tail_de0.87836285
126MP0002796_impaired_skin_barrier0.87267241
127MP0002752_abnormal_somatic_nervous0.86977277
128MP0008007_abnormal_cellular_replicative0.86008007
129MP0002060_abnormal_skin_morphology0.84598017
130MP0004084_abnormal_cardiac_muscle0.84565191
131MP0004185_abnormal_adipocyte_glucose0.82679445
132MP0003315_abnormal_perineum_morphology0.82488627
133MP0002092_abnormal_eye_morphology0.81580858
134MP0002882_abnormal_neuron_morphology0.81552218
135MP0005253_abnormal_eye_physiology0.81239561
136MP0001485_abnormal_pinna_reflex0.80824703
137MP0000371_diluted_coat_color0.80596203
138MP0005389_reproductive_system_phenotype0.80236728
139MP0002006_tumorigenesis0.80087566
140MP0002090_abnormal_vision0.79399623
141MP0009250_abnormal_appendicular_skeleto0.78706634
142MP0002277_abnormal_respiratory_mucosa0.78227190
143MP0003755_abnormal_palate_morphology0.78183152
144MP0005501_abnormal_skin_physiology0.78155515
145MP0003935_abnormal_craniofacial_develop0.78014614
146MP0005367_renal/urinary_system_phenotyp0.77982776
147MP0000516_abnormal_urinary_system0.77982776
148MP0003566_abnormal_cell_adhesion0.77431227
149MP0002233_abnormal_nose_morphology0.76519115
150MP0005379_endocrine/exocrine_gland_phen0.76502666
151MP0000490_abnormal_crypts_of0.75846744
152MP0008770_decreased_survivor_rate0.74832436
153MP0004087_abnormal_muscle_fiber0.74707247
154MP0008932_abnormal_embryonic_tissue0.73929851
155MP0006072_abnormal_retinal_apoptosis0.73855131
156MP0005330_cardiomyopathy0.73743320
157MP0003943_abnormal_hepatobiliary_system0.73211857
158MP0005197_abnormal_uvea_morphology0.72610541
159MP0001186_pigmentation_phenotype0.70830223
160MP0000681_abnormal_thyroid_gland0.70186077
161MP0004811_abnormal_neuron_physiology0.68837589
162MP0003718_maternal_effect0.68825342
163MP0003186_abnormal_redox_activity0.68610633
164MP0000432_abnormal_head_morphology0.67161213
165MP0000647_abnormal_sebaceous_gland0.66186537
166MP0000747_muscle_weakness0.63675100
167MP0003656_abnormal_erythrocyte_physiolo0.62488673
168MP0003763_abnormal_thymus_physiology0.61123009
169MP0002114_abnormal_axial_skeleton0.60857157
170MP0000751_myopathy0.60368578
171MP0000428_abnormal_craniofacial_morphol0.59705764
172MP0010630_abnormal_cardiac_muscle0.59583396
173MP0002210_abnormal_sex_determination0.58291013
174MP0001324_abnormal_eye_pigmentation0.58261818
175MP0005623_abnormal_meninges_morphology0.58022163

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.80870964
2Myelodysplasia (HP:0002863)3.61542544
3Increased serum pyruvate (HP:0003542)3.60571328
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56498518
5Abnormality of glycolysis (HP:0004366)3.55651066
6Abnormal hair whorl (HP:0010721)3.43632244
7Aplastic anemia (HP:0001915)3.35527894
8Chromsome breakage (HP:0040012)3.32674031
9True hermaphroditism (HP:0010459)3.23919905
10Cortical dysplasia (HP:0002539)3.17844589
11Medial flaring of the eyebrow (HP:0010747)3.11408374
12Nephrogenic diabetes insipidus (HP:0009806)3.09460375
13Abnormality of methionine metabolism (HP:0010901)3.07885923
14Gait imbalance (HP:0002141)3.05485898
15Progressive external ophthalmoplegia (HP:0000590)3.04561443
16Hyperventilation (HP:0002883)2.93607267
17Congenital primary aphakia (HP:0007707)2.85074648
18Ependymoma (HP:0002888)2.84340018
19Abnormality of the heme biosynthetic pathway (HP:0010472)2.83134840
20Rhabdomyosarcoma (HP:0002859)2.81488460
21Focal motor seizures (HP:0011153)2.80060831
22Colon cancer (HP:0003003)2.75626076
23Small intestinal stenosis (HP:0012848)2.71160116
24Duodenal stenosis (HP:0100867)2.71160116
25Protruding tongue (HP:0010808)2.71157534
26Nemaline bodies (HP:0003798)2.65470393
27Tubulointerstitial nephritis (HP:0001970)2.62296650
28Fatigue (HP:0012378)2.61768334
29Multiple enchondromatosis (HP:0005701)2.58125230
30Pancreatic fibrosis (HP:0100732)2.56835522
31Exercise-induced muscle cramps (HP:0003710)2.54644057
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54048449
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.54048449
34Pancreatic islet-cell hyperplasia (HP:0004510)2.53680516
35Medulloblastoma (HP:0002885)2.52893115
36Febrile seizures (HP:0002373)2.52786567
37Increased nuchal translucency (HP:0010880)2.52422349
38Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.51399858
39Poor coordination (HP:0002370)2.43188389
40Selective tooth agenesis (HP:0001592)2.41402149
41Acute myeloid leukemia (HP:0004808)2.41200921
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.38753913
43Septo-optic dysplasia (HP:0100842)2.38401690
44Birth length less than 3rd percentile (HP:0003561)2.36649272
45Vaginal atresia (HP:0000148)2.34943201
46Abnormal ciliary motility (HP:0012262)2.34775470
47Muscle fiber inclusion bodies (HP:0100299)2.33878010
48Abnormality of the labia minora (HP:0012880)2.33524185
49Neuroblastoma (HP:0003006)2.32540798
50Primitive neuroectodermal tumor (HP:0030065)2.32540798
51Neuroblastic tumors (HP:0004376)2.32540798
52Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.32540798
53Abnormality of the duodenum (HP:0002246)2.32021545
54Genital tract atresia (HP:0001827)2.31522360
55Sloping forehead (HP:0000340)2.29482141
56Absent speech (HP:0001344)2.28774533
57Cafe-au-lait spot (HP:0000957)2.28496525
58Abnormality of incisor morphology (HP:0011063)2.25832706
59Hypothermia (HP:0002045)2.25373584
60Neoplasm of the colon (HP:0100273)2.24643685
61Abnormality of the musculature of the pelvis (HP:0001469)2.23518968
62Abnormality of the hip-girdle musculature (HP:0001445)2.23518968
63Fair hair (HP:0002286)2.20524583
64Abnormal respiratory epithelium morphology (HP:0012253)2.16746222
65Abnormal respiratory motile cilium morphology (HP:0005938)2.16746222
66Type I transferrin isoform profile (HP:0003642)2.11970446
67Papillary thyroid carcinoma (HP:0002895)2.11292003
68Abnormality of the left ventricular outflow tract (HP:0011103)2.11122465
69Subaortic stenosis (HP:0001682)2.11122465
70Optic nerve hypoplasia (HP:0000609)2.09359960
71Pancreatic cysts (HP:0001737)2.09133513
72Epileptic encephalopathy (HP:0200134)2.08556695
73Intestinal atresia (HP:0011100)2.08190194
74Broad-based gait (HP:0002136)2.07861553
75Nephroblastoma (Wilms tumor) (HP:0002667)2.07794826
76Orthostatic hypotension (HP:0001278)2.06811891
77Progressive muscle weakness (HP:0003323)2.06809675
78Progressive macrocephaly (HP:0004481)2.06333074
79Progressive inability to walk (HP:0002505)2.06320481
80Preaxial hand polydactyly (HP:0001177)2.05286675
81Postaxial foot polydactyly (HP:0001830)2.05037349
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04070757
83Abnormality of the preputium (HP:0100587)2.03919589
84Astrocytoma (HP:0009592)2.03281589
85Abnormality of the astrocytes (HP:0100707)2.03281589
86Spastic diplegia (HP:0001264)2.03115329
8711 pairs of ribs (HP:0000878)2.02752988
88Curly hair (HP:0002212)2.00828785
89Cupped ear (HP:0000378)1.99875559
90Abnormality of the renal collecting system (HP:0004742)1.99798022
91Abnormal respiratory motile cilium physiology (HP:0012261)1.99645913
92White forelock (HP:0002211)1.99549369
93Embryonal renal neoplasm (HP:0011794)1.99301266
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99185250
95Acute necrotizing encephalopathy (HP:0006965)1.99094835
96Deep philtrum (HP:0002002)1.98784679
97Patchy hypopigmentation of hair (HP:0011365)1.97053550
98Generalized hypopigmentation of hair (HP:0011358)1.94681803
99Prominent nose (HP:0000448)1.94115018
100Duplicated collecting system (HP:0000081)1.93676681
101Sensory axonal neuropathy (HP:0003390)1.93403259
102Overlapping toe (HP:0001845)1.93342658
103Pelvic girdle muscle weakness (HP:0003749)1.92369898
104Abnormality of the nasolacrimal system (HP:0000614)1.91053773
105Glioma (HP:0009733)1.89709603
106Molar tooth sign on MRI (HP:0002419)1.89082662
107Abnormality of midbrain morphology (HP:0002418)1.89082662
108Atonic seizures (HP:0010819)1.88892768
109Cystic hygroma (HP:0000476)1.88873104
110Heterochromia iridis (HP:0001100)1.87483182
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.87435359
112Occipital encephalocele (HP:0002085)1.87198477
113Absent/shortened dynein arms (HP:0200106)1.86677129
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.86677129
115Absent eyebrow (HP:0002223)1.86556096
116Abnormality of the lacrimal duct (HP:0011481)1.86428601
117Male pseudohermaphroditism (HP:0000037)1.86173599
118Meckel diverticulum (HP:0002245)1.84707378
119Adrenal hypoplasia (HP:0000835)1.84641562
120Astigmatism (HP:0000483)1.83010255
121Ankyloglossia (HP:0010296)1.81559509
122Gaze-evoked nystagmus (HP:0000640)1.80522444
123Freckling (HP:0001480)1.80031717
1243-Methylglutaconic aciduria (HP:0003535)1.79924935
125Aplasia/Hypoplasia of the lens (HP:0008063)1.79425822
126Abnormality of the ileum (HP:0001549)1.78839624
127Hyperinsulinemic hypoglycemia (HP:0000825)1.78712964
128Facial cleft (HP:0002006)1.78481964
129Fetal akinesia sequence (HP:0001989)1.77857474
130Abnormality of chromosome segregation (HP:0002916)1.77609997
131Ectopic kidney (HP:0000086)1.76336592
132Hypoplastic iliac wings (HP:0002866)1.76207554
133Insidious onset (HP:0003587)1.75961012
134Termporal pattern (HP:0011008)1.75961012
135Premature ovarian failure (HP:0008209)1.75845591
136Abnormality of chromosome stability (HP:0003220)1.74837090
137Abnormality of the septum pellucidum (HP:0007375)1.74556477
138Long clavicles (HP:0000890)1.74333187
139Embryonal neoplasm (HP:0002898)1.71977737
140Abnormality of the intrinsic pathway (HP:0010989)1.71918683
141Nasolacrimal duct obstruction (HP:0000579)1.71637441
142Parakeratosis (HP:0001036)1.71506525
143Biliary tract neoplasm (HP:0100574)1.71347972
144Neuroectodermal neoplasm (HP:0030061)1.71032687
145Neuroepithelial neoplasm (HP:0030063)1.71032687
146Nervous tissue neoplasm (HP:0030060)1.71032687
147Aganglionic megacolon (HP:0002251)1.70790434
148Stomach cancer (HP:0012126)1.70697225
149Esotropia (HP:0000565)1.70655737
150Malignant gastrointestinal tract tumors (HP:0006749)1.70463604
151Gastrointestinal carcinoma (HP:0002672)1.70463604
152Nephronophthisis (HP:0000090)1.69717021
153Homocystinuria (HP:0002156)1.69684408
154Abnormality of homocysteine metabolism (HP:0010919)1.69684408
155Absent septum pellucidum (HP:0001331)1.69630946
156Mitochondrial inheritance (HP:0001427)1.69511474
157Postnatal microcephaly (HP:0005484)1.69475193
158Thyroid carcinoma (HP:0002890)1.69158401
159Neoplasm of the adrenal cortex (HP:0100641)1.69146204
160Lissencephaly (HP:0001339)1.68655652
161Abnormality of the carotid arteries (HP:0005344)1.67870930
162Abnormal auditory evoked potentials (HP:0006958)1.67159653
163Neoplasm of the small intestine (HP:0100833)1.66863894
164Neoplasm of the adrenal gland (HP:0100631)1.66761820
165Microvesicular hepatic steatosis (HP:0001414)1.66599634
166Bone marrow hypocellularity (HP:0005528)1.65829467
167Type 2 muscle fiber atrophy (HP:0003554)1.65024121
168Aplasia cutis congenita (HP:0001057)1.64565073
169Progressive cerebellar ataxia (HP:0002073)1.64523671
170High anterior hairline (HP:0009890)1.63902721
171Abnormal lung lobation (HP:0002101)1.63845268
172Reduced antithrombin III activity (HP:0001976)1.63531574
173Missing ribs (HP:0000921)1.63034749
174Abnormality of the incisor (HP:0000676)1.62590498
175Renal Fanconi syndrome (HP:0001994)1.62451894
176Pancytopenia (HP:0001876)1.62390503
177Uterine neoplasm (HP:0010784)1.61690607
178Areflexia of lower limbs (HP:0002522)1.61325381
179Abnormality of the corticospinal tract (HP:0002492)1.59751685
180Short foot (HP:0001773)1.59621130
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.59567112
182Gastroesophageal reflux (HP:0002020)1.59566916
183Abnormality of DNA repair (HP:0003254)1.59523867
184Asymmetry of the thorax (HP:0001555)1.59503511
185Broad foot (HP:0001769)1.59450409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.53757857
2TNIK3.28786735
3TTK3.15244779
4STK162.83820305
5MAP2K72.69474547
6MKNK12.64639362
7MKNK22.55304701
8NEK12.50269551
9FRK2.20439579
10AKT32.19221506
11VRK12.14785868
12TRIM282.10944694
13MAPK132.07954175
14TAF12.03499281
15STK38L2.00845254
16MST41.95688127
17SRPK11.93556730
18MARK11.91936536
19ZAK1.82955074
20TSSK61.68151803
21YES11.66096510
22PLK31.62934859
23ERBB31.62516889
24BMPR1B1.61655784
25SCYL21.60497688
26TXK1.57972761
27LATS11.49159876
28PLK21.46825973
29PRPF4B1.46485544
30MAP3K121.45544072
31SIK31.43751344
32PNCK1.42552201
33RPS6KA41.39387357
34CDK31.32509844
35ADRBK21.32172623
36DYRK21.31676531
37PDK21.31490267
38EPHA41.31196233
39SGK21.26916654
40NEK61.25486448
41CDK91.24907664
42NLK1.21805734
43PBK1.21780909
44CDC71.20816043
45BCR1.17698596
46STK101.15364124
47VRK21.15296404
48FGFR21.14556238
49IRAK21.12712345
50BMPR21.11522748
51IRAK41.11221835
52ALK1.11085324
53EIF2AK21.08712830
54MAP3K101.02969242
55OXSR11.01424631
56AURKB1.00989754
57CSNK1G30.97936438
58CDK60.95802520
59MAP3K40.94699358
60ERBB40.93963162
61NUAK10.93335612
62PLK40.90374551
63MST1R0.89329296
64CSNK1A1L0.88152953
65GRK70.87349063
66NTRK30.87138731
67BRAF0.86725308
68NEK90.85342888
69CDK80.85140948
70MUSK0.82751557
71SGK2230.82358860
72SGK4940.82358860
73CDK70.81826105
74OBSCN0.81471562
75WEE10.81203173
76BRD40.81037449
77CDK40.80315033
78STK30.79895861
79EIF2AK10.77870828
80NME10.77526772
81PAK40.75065168
82LATS20.74842046
83ATR0.74279416
84MAPKAPK50.71567079
85CSNK1G10.69507610
86DYRK30.68371138
87CSNK1G20.68054847
88PIM20.67010219
89BUB10.66581570
90CDK190.66328962
91DYRK1A0.64678200
92MAP3K140.64389041
93MAP3K80.64276687
94PKN10.64249977
95RPS6KA50.63678316
96PRKCE0.61869242
97CSNK1E0.61588488
98CDK120.61279326
99GRK10.60088692
100CCNB10.60075559
101CSNK2A20.58750560
102TLK10.58591332
103NEK20.58556333
104RPS6KB10.58200794
105STK40.57630548
106FGFR10.57470444
107TNK20.57258345
108PRKCG0.56778878
109CLK10.53620432
110CDK20.51665841
111IRAK10.51132137
112ATM0.50408750
113EIF2AK30.49675821
114MAP4K20.49244557
115MELK0.49197190
116CAMK2B0.48664911
117WNK30.48295314
118PASK0.47449827
119KSR10.47112068
120TGFBR10.46518945
121ACVR1B0.44504900
122STK390.44488164
123IRAK30.43590282
124LIMK10.43122530
125TRPM70.43080359
126CAMK2A0.42351836
127BRSK10.41761737
128PRKDC0.41612354
129CHEK20.41344570
130AURKA0.41269133
131BRSK20.40627431
132PIK3CG0.40565596
133PLK10.40405377
134PIK3CA0.40358369
135BLK0.39660335
136UHMK10.38962331
137MINK10.38957516
138CSNK2A10.38427949
139NME20.36644935
140CDK10.36544265
141LYN0.35590520
142NTRK20.34902441
143ADRBK10.34363530
144TEC0.34324874
145AKT20.33123168
146CHEK10.32738754
147MET0.29579558
148MARK30.27289486
149RPS6KB20.24588343
150MAPK140.23479444
151FGR0.22498964

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.89062238
2Nicotine addiction_Homo sapiens_hsa050332.64023143
3Fanconi anemia pathway_Homo sapiens_hsa034602.46389530
4Mismatch repair_Homo sapiens_hsa034302.44644678
5Proteasome_Homo sapiens_hsa030502.36062379
6Nucleotide excision repair_Homo sapiens_hsa034202.30750852
7DNA replication_Homo sapiens_hsa030302.26538280
8Homologous recombination_Homo sapiens_hsa034402.19736587
9Basal transcription factors_Homo sapiens_hsa030222.08953650
10Spliceosome_Homo sapiens_hsa030402.03771908
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00831408
12Base excision repair_Homo sapiens_hsa034102.00435018
13Non-homologous end-joining_Homo sapiens_hsa034501.97791658
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91594868
15Pyrimidine metabolism_Homo sapiens_hsa002401.90054358
16Protein export_Homo sapiens_hsa030601.87710981
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86563923
18RNA degradation_Homo sapiens_hsa030181.86374570
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67949487
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.67184529
21Oxidative phosphorylation_Homo sapiens_hsa001901.65461583
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57985603
23Selenocompound metabolism_Homo sapiens_hsa004501.54379311
24Serotonergic synapse_Homo sapiens_hsa047261.47215457
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46234537
26Phototransduction_Homo sapiens_hsa047441.43537446
27Cell cycle_Homo sapiens_hsa041101.42276734
28Purine metabolism_Homo sapiens_hsa002301.38467271
29RNA transport_Homo sapiens_hsa030131.38400989
30Taste transduction_Homo sapiens_hsa047421.38216454
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37201644
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35897175
33Biosynthesis of amino acids_Homo sapiens_hsa012301.33858011
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33173985
35Pyruvate metabolism_Homo sapiens_hsa006201.32574445
36Huntingtons disease_Homo sapiens_hsa050161.28250885
37Parkinsons disease_Homo sapiens_hsa050121.26651359
38Collecting duct acid secretion_Homo sapiens_hsa049661.26508291
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24551766
40Morphine addiction_Homo sapiens_hsa050321.23301070
41Thyroid cancer_Homo sapiens_hsa052161.17918485
42Propanoate metabolism_Homo sapiens_hsa006401.17859241
43mRNA surveillance pathway_Homo sapiens_hsa030151.17470858
44Carbon metabolism_Homo sapiens_hsa012001.11301679
45Autoimmune thyroid disease_Homo sapiens_hsa053201.06879465
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05125703
47Axon guidance_Homo sapiens_hsa043601.03385054
48GABAergic synapse_Homo sapiens_hsa047271.02826576
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02063324
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01279960
51Alzheimers disease_Homo sapiens_hsa050100.99784198
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98683298
53Glutamatergic synapse_Homo sapiens_hsa047240.95394918
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94714351
55Long-term depression_Homo sapiens_hsa047300.92885573
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92177476
57Adherens junction_Homo sapiens_hsa045200.91519340
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89960209
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89855877
60Amphetamine addiction_Homo sapiens_hsa050310.89768824
61Synaptic vesicle cycle_Homo sapiens_hsa047210.89396965
62Lysine degradation_Homo sapiens_hsa003100.85754977
63Circadian entrainment_Homo sapiens_hsa047130.85714651
64Type I diabetes mellitus_Homo sapiens_hsa049400.84409374
65Viral carcinogenesis_Homo sapiens_hsa052030.82885681
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82576582
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80445194
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80263220
69Alcoholism_Homo sapiens_hsa050340.76547477
70Ether lipid metabolism_Homo sapiens_hsa005650.76427712
71Rheumatoid arthritis_Homo sapiens_hsa053230.76168505
72Dopaminergic synapse_Homo sapiens_hsa047280.75606438
73Pentose phosphate pathway_Homo sapiens_hsa000300.75060249
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74986578
75Epstein-Barr virus infection_Homo sapiens_hsa051690.74014336
76Olfactory transduction_Homo sapiens_hsa047400.69578503
77Arachidonic acid metabolism_Homo sapiens_hsa005900.68041449
78Ribosome_Homo sapiens_hsa030100.67916242
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66757120
80Vibrio cholerae infection_Homo sapiens_hsa051100.64448930
81Calcium signaling pathway_Homo sapiens_hsa040200.62929848
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61645925
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61593209
84Wnt signaling pathway_Homo sapiens_hsa043100.61462441
85Cocaine addiction_Homo sapiens_hsa050300.61075347
86MicroRNAs in cancer_Homo sapiens_hsa052060.60669548
87Graft-versus-host disease_Homo sapiens_hsa053320.58234269
88Long-term potentiation_Homo sapiens_hsa047200.58230296
89Hematopoietic cell lineage_Homo sapiens_hsa046400.58095472
90One carbon pool by folate_Homo sapiens_hsa006700.57642162
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56634819
92Vitamin B6 metabolism_Homo sapiens_hsa007500.54349777
93Colorectal cancer_Homo sapiens_hsa052100.53224651
94Melanoma_Homo sapiens_hsa052180.52881962
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52380279
96Systemic lupus erythematosus_Homo sapiens_hsa053220.52107803
97Fatty acid elongation_Homo sapiens_hsa000620.51977213
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51314424
99Sphingolipid metabolism_Homo sapiens_hsa006000.51302292
100Hippo signaling pathway_Homo sapiens_hsa043900.50456222
101Allograft rejection_Homo sapiens_hsa053300.49803814
102Primary immunodeficiency_Homo sapiens_hsa053400.49597897
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48658891
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48251956
105Ovarian steroidogenesis_Homo sapiens_hsa049130.48187478
106Cholinergic synapse_Homo sapiens_hsa047250.47599225
107Phagosome_Homo sapiens_hsa041450.47066635
108TGF-beta signaling pathway_Homo sapiens_hsa043500.45781548
109Oocyte meiosis_Homo sapiens_hsa041140.44298488
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44258649
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42447403
112Tight junction_Homo sapiens_hsa045300.42394959
113p53 signaling pathway_Homo sapiens_hsa041150.42282765
114Measles_Homo sapiens_hsa051620.41729427
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41699695
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41426171
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40967441
118Circadian rhythm_Homo sapiens_hsa047100.40435861
119Chronic myeloid leukemia_Homo sapiens_hsa052200.38049646
120Herpes simplex infection_Homo sapiens_hsa051680.37178560
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37003967
122N-Glycan biosynthesis_Homo sapiens_hsa005100.35548542
123ErbB signaling pathway_Homo sapiens_hsa040120.34977417
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.34880991
125Steroid biosynthesis_Homo sapiens_hsa001000.34623938
126Small cell lung cancer_Homo sapiens_hsa052220.34356506
127Prostate cancer_Homo sapiens_hsa052150.33829790
128Regulation of autophagy_Homo sapiens_hsa041400.33391638
129Proteoglycans in cancer_Homo sapiens_hsa052050.32650290
130Asthma_Homo sapiens_hsa053100.32020801
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31521607
132Legionellosis_Homo sapiens_hsa051340.31111644
133Glutathione metabolism_Homo sapiens_hsa004800.28701463
134Pancreatic cancer_Homo sapiens_hsa052120.28120125
135Shigellosis_Homo sapiens_hsa051310.28016525
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.27785915
137HTLV-I infection_Homo sapiens_hsa051660.27480637
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27045318
139cAMP signaling pathway_Homo sapiens_hsa040240.26810387
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26593233
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23212064
142Metabolic pathways_Homo sapiens_hsa011000.21983163
143Hepatitis B_Homo sapiens_hsa051610.21404052
144Hedgehog signaling pathway_Homo sapiens_hsa043400.18687342
145Arginine and proline metabolism_Homo sapiens_hsa003300.18048620
146Pathways in cancer_Homo sapiens_hsa052000.16427044
147Endometrial cancer_Homo sapiens_hsa052130.14772122
148Glucagon signaling pathway_Homo sapiens_hsa049220.13876615
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12879013
150Basal cell carcinoma_Homo sapiens_hsa052170.11581990
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11037589
152Renal cell carcinoma_Homo sapiens_hsa052110.10897078
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04780196
154Fatty acid degradation_Homo sapiens_hsa000710.04089485
155beta-Alanine metabolism_Homo sapiens_hsa004100.03820833

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