ALLC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.73134260
2axonemal dynein complex assembly (GO:0070286)9.69475788
3reproduction (GO:0000003)9.64412932
4spermatid development (GO:0007286)9.58436260
5pattern specification involved in kidney development (GO:0061004)9.56703244
6motile cilium assembly (GO:0044458)9.34585578
7cilium or flagellum-dependent cell motility (GO:0001539)9.11615897
8regulation of cilium movement (GO:0003352)8.19017815
9response to pheromone (GO:0019236)8.14587952
10cilium movement (GO:0003341)7.83863259
11single fertilization (GO:0007338)7.43827685
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.38146888
13synaptonemal complex organization (GO:0070193)7.18707425
14synaptonemal complex assembly (GO:0007130)7.14389461
15male meiosis (GO:0007140)7.02794625
16sperm capacitation (GO:0048240)6.91204451
17piRNA metabolic process (GO:0034587)6.87294524
18negative regulation of inclusion body assembly (GO:0090084)6.78089804
19microtubule depolymerization (GO:0007019)6.67156006
20spermatogenesis (GO:0007283)6.56375740
21male gamete generation (GO:0048232)6.54086058
22fertilization (GO:0009566)6.25909380
23organic cation transport (GO:0015695)6.19063668
24gamete generation (GO:0007276)6.01234225
25regulation of inclusion body assembly (GO:0090083)5.75975809
26phosphatidylethanolamine biosynthetic process (GO:0006646)5.74325725
27protein targeting to Golgi (GO:0000042)5.64820087
28rRNA methylation (GO:0031167)5.62109703
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.50444190
30establishment of protein localization to Golgi (GO:0072600)5.45902322
31calcium ion-dependent exocytosis (GO:0017156)5.44277165
32spermatid nucleus differentiation (GO:0007289)5.34795035
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.30948213
34germ cell development (GO:0007281)5.30215096
35phosphatidylethanolamine metabolic process (GO:0046337)5.26145426
36retrograde transport, vesicle recycling within Golgi (GO:0000301)5.20534365
37cell recognition (GO:0008037)5.01137507
38chromosome condensation (GO:0030261)4.97955323
39cellular ketone body metabolic process (GO:0046950)4.95635624
40ventricular system development (GO:0021591)4.89120661
41chromosome organization involved in meiosis (GO:0070192)4.88261654
42glycerol ether metabolic process (GO:0006662)4.84658864
43rRNA modification (GO:0000154)4.84361610
44regulation of microtubule-based movement (GO:0060632)4.79725264
45positive regulation of Rab GTPase activity (GO:0032851)4.77530918
46regulation of Rab GTPase activity (GO:0032313)4.77530918
47male meiosis I (GO:0007141)4.72582115
48multicellular organismal reproductive process (GO:0048609)4.71375592
49DNA packaging (GO:0006323)4.71005504
50microtubule severing (GO:0051013)4.60319087
51centriole replication (GO:0007099)4.59402625
52coenzyme catabolic process (GO:0009109)4.54687667
53seminiferous tubule development (GO:0072520)4.51960942
54DNA methylation involved in gamete generation (GO:0043046)4.50978194
55regulation of retinoic acid receptor signaling pathway (GO:0048385)4.50427978
56ether metabolic process (GO:0018904)4.47777466
57ketone body metabolic process (GO:1902224)4.33074253
58multicellular organismal movement (GO:0050879)4.31854567
59musculoskeletal movement (GO:0050881)4.31854567
60regulation of transcription involved in cell fate commitment (GO:0060850)4.30973103
61meiotic nuclear division (GO:0007126)4.27779055
62single strand break repair (GO:0000012)4.25917188
63chaperone-mediated protein complex assembly (GO:0051131)4.24159076
64response to acidic pH (GO:0010447)4.23305723
65sexual reproduction (GO:0019953)4.19232830
66mitotic G1 DNA damage checkpoint (GO:0031571)4.06809090
67regulation of phosphoprotein phosphatase activity (GO:0043666)4.05379169
68protein localization to Golgi apparatus (GO:0034067)4.03781919
69cellular response to pH (GO:0071467)4.00115618
70segment specification (GO:0007379)3.97879766
71left/right pattern formation (GO:0060972)3.88810388
72meiosis I (GO:0007127)3.88379433
73multicellular organismal development (GO:0007275)3.78886053
74monoubiquitinated protein deubiquitination (GO:0035520)3.76124229
75sequestering of actin monomers (GO:0042989)3.68325941
76mitotic G1/S transition checkpoint (GO:0044819)3.65474711
77protein K11-linked deubiquitination (GO:0035871)3.61556747
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60257000
79G1 DNA damage checkpoint (GO:0044783)3.60248651
80histone H3-K9 demethylation (GO:0033169)3.59879073
81nucleosome disassembly (GO:0006337)3.58489302
82protein-DNA complex disassembly (GO:0032986)3.58489302
83genitalia morphogenesis (GO:0035112)3.47749235
84cranial nerve morphogenesis (GO:0021602)3.47454549
85microtubule polymerization or depolymerization (GO:0031109)3.47108762
86regulation of spindle checkpoint (GO:0090231)3.37122354
87protein polyglutamylation (GO:0018095)3.31267280
88membrane protein intracellular domain proteolysis (GO:0031293)3.30990143
89meiotic cell cycle (GO:0051321)3.30219064
90negative regulation of Rho protein signal transduction (GO:0035024)3.25953388
91nucleoside diphosphate phosphorylation (GO:0006165)3.24638753
92homeostasis of number of cells within a tissue (GO:0048873)3.16972426
93alditol metabolic process (GO:0019400)3.15864113
94GTP biosynthetic process (GO:0006183)3.14766380
95polyol catabolic process (GO:0046174)3.13523414
96protein refolding (GO:0042026)3.11832836
97regulation of centriole replication (GO:0046599)3.11163256
98nucleus organization (GO:0006997)3.10642196
99positive regulation of endothelial cell differentiation (GO:0045603)3.04113772
100cellular biogenic amine biosynthetic process (GO:0042401)3.02476867
101interferon-gamma secretion (GO:0072643)3.01802768
102protein localization to cilium (GO:0061512)2.97104551
103carnitine transport (GO:0015879)2.96228854
104amino-acid betaine transport (GO:0015838)2.96228854
105outer ear morphogenesis (GO:0042473)2.94048465
106glycolytic process (GO:0006096)2.91282515
107peptidyl-threonine dephosphorylation (GO:0035970)2.91133328
108meiotic cell cycle process (GO:1903046)2.90192306
109cofactor catabolic process (GO:0051187)2.89796701
110mitotic sister chromatid cohesion (GO:0007064)2.89494708
111histone exchange (GO:0043486)2.88751261
112cerebral cortex neuron differentiation (GO:0021895)2.88019956
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.87661301
114cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87334503
115amine biosynthetic process (GO:0009309)2.87223543
116positive regulation of macrophage activation (GO:0043032)2.85727262
117synapsis (GO:0007129)2.84592115
118UTP biosynthetic process (GO:0006228)2.82610947
119carnitine transmembrane transport (GO:1902603)2.80739573
120polyamine biosynthetic process (GO:0006596)2.77095972
121cilium organization (GO:0044782)2.71838901
122cilium morphogenesis (GO:0060271)2.68024870
123microtubule-based movement (GO:0007018)2.66799765
124centriole assembly (GO:0098534)2.64570285
125cellular component assembly involved in morphogenesis (GO:0010927)2.63411216
126glycerol metabolic process (GO:0006071)2.62612533
127cilium assembly (GO:0042384)2.61471997
128axoneme assembly (GO:0035082)2.61193858
129chromatin silencing (GO:0006342)2.55820906
130UTP metabolic process (GO:0046051)2.54034842
131RNA localization (GO:0006403)2.51015628
132lactate metabolic process (GO:0006089)2.50783792
133intraciliary transport (GO:0042073)2.49507767
134gene silencing by RNA (GO:0031047)2.44258128
135RNA destabilization (GO:0050779)2.43861327
136negative regulation of organelle assembly (GO:1902116)2.41246673
137cell wall macromolecule metabolic process (GO:0044036)13.8741431
138cell wall macromolecule catabolic process (GO:0016998)13.8741431
139fusion of sperm to egg plasma membrane (GO:0007342)13.8518722
140sperm motility (GO:0030317)13.5017951
141acrosome assembly (GO:0001675)12.0475440
142acrosome reaction (GO:0007340)11.6859332
143sperm-egg recognition (GO:0035036)11.6589502
144multicellular organism reproduction (GO:0032504)11.2017867
145binding of sperm to zona pellucida (GO:0007339)10.5618663
146plasma membrane fusion (GO:0045026)10.5478564
147cell-cell recognition (GO:0009988)10.4452087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.96923711
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.13843775
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61929037
4EZH2_22144423_ChIP-Seq_EOC_Human3.45477693
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35817338
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33103067
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09231264
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83118536
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76382194
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61519971
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55828459
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34979176
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.31502859
14VDR_22108803_ChIP-Seq_LS180_Human2.22734883
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17907826
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15543837
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.11650828
18ZNF274_21170338_ChIP-Seq_K562_Hela2.09630874
19* POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.07776132
20* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07776132
21ERA_21632823_ChIP-Seq_H3396_Human2.05138903
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04380247
23NANOG_20526341_ChIP-Seq_ESCs_Human2.04091943
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0959496
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.96462664
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96351630
27CTCF_27219007_Chip-Seq_Bcells_Human1.93103224
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91985051
29* RAC3_21632823_ChIP-Seq_H3396_Human1.84745499
30KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81989203
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.79975404
32SMC4_20622854_ChIP-Seq_HELA_Human1.79272787
33STAT1_17558387_ChIP-Seq_HELA_Human1.78256707
34E2F1_20622854_ChIP-Seq_HELA_Human1.77346842
35P68_20966046_ChIP-Seq_HELA_Human1.74426037
36CTCF_20526341_ChIP-Seq_ESCs_Human1.72883155
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71746555
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.70696557
39* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68953174
40BCL6_27268052_Chip-Seq_Bcells_Human1.68168571
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.66745666
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66277895
43* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64169242
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63980496
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63702114
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.63238733
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63022061
48PHF8_20622854_ChIP-Seq_HELA_Human1.62540023
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62199913
50OCT4_20526341_ChIP-Seq_ESCs_Human1.58534947
51FUS_26573619_Chip-Seq_HEK293_Human1.58432329
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.57453845
53BCOR_27268052_Chip-Seq_Bcells_Human1.57223840
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56392683
55MYC_19829295_ChIP-Seq_ESCs_Human1.55762723
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.51706190
57TAF2_19829295_ChIP-Seq_ESCs_Human1.49706195
58* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48765044
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.48166805
60KDM2B_26808549_Chip-Seq_REH_Human1.47848111
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47049208
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46684440
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.43928114
64* TP63_22573176_ChIP-Seq_HFKS_Human1.39781950
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.39356945
66LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39067038
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.38666943
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.38502961
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38015647
70AR_21572438_ChIP-Seq_LNCaP_Human1.37571174
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.37570809
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37496708
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36454076
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36426588
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35980266
76* LXR_22292898_ChIP-Seq_THP-1_Human1.35667163
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.34398645
78TBL1_22424771_ChIP-Seq_293T_Human1.33759261
79* P300_27268052_Chip-Seq_Bcells_Human1.33558014
80P53_21459846_ChIP-Seq_SAOS-2_Human1.33474755
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32906937
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.32559312
83* RBPJ_21746931_ChIP-Seq_IB4_Human1.32332183
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.31893656
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31798222
86CBP_20019798_ChIP-Seq_JUKART_Human1.31798222
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29882792
88DROSHA_22980978_ChIP-Seq_HELA_Human1.28283076
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28182234
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27210460
91* TP53_18474530_ChIP-ChIP_U2OS_Human1.27072236
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26940042
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.26720523
94* ETV1_20927104_ChIP-Seq_GIST48_Human1.25927541
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25780989
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25687615
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25384433
98PHF8_20622853_ChIP-Seq_HELA_Human1.25204050
99REST_21632747_ChIP-Seq_MESCs_Mouse1.24865501
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24372715
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24159586
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23126686
103ER_23166858_ChIP-Seq_MCF-7_Human1.21663610
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21298591
105* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20446474
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.20010929
107GATA6_21074721_ChIP-Seq_CACO-2_Human1.20008090
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19213989
109* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18898550
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17803667
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16969779
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16693055
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16003436
114SPI1_26923725_Chip-Seq_HPCs_Mouse1.15560499
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14628042
116STAT1_20625510_ChIP-Seq_HELA_Human1.14503929
117* GF1_26923725_Chip-Seq_HPCs_Mouse1.14402334
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.11446730
119* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11240331
120GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10699419
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10574010
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.10031476
123* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08123746
124ESET_19884257_ChIP-Seq_ESCs_Mouse1.07807688
125RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07622201
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07344730
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07147623
128* RUNX2_22187159_ChIP-Seq_PCA_Human1.07115472
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06869583
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.06504263
131* AR_25329375_ChIP-Seq_VCAP_Human1.06450801
132* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06213821
133ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05802655
134ERG_20517297_ChIP-Seq_VCAP_Human1.05488857
135SA1_27219007_Chip-Seq_Bcells_Human1.04824297
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.04397323
137LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04290047
138EED_16625203_ChIP-ChIP_MESCs_Mouse1.03469605
139* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03172873
140FLI1_21867929_ChIP-Seq_CD8_Mouse1.01804096
141EZH2_27304074_Chip-Seq_ESCs_Mouse1.01217122
142TET1_21451524_ChIP-Seq_MESCs_Mouse1.01103415
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01083004
144NFYA_21822215_ChIP-Seq_K562_Human0.99993458
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99889271
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99885169
147* OCT1_27270436_Chip-Seq_PROSTATE_Human0.99833006
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99511358
149P53_22387025_ChIP-Seq_ESCs_Mouse0.99485932
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.98553940
151RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98336820
152JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98195866
153HOXB7_26014856_ChIP-Seq_BT474_Human0.98193526
154* P300_19829295_ChIP-Seq_ESCs_Human0.97969369
155CTCF_21964334_Chip-Seq_Bcells_Human0.97396438
156OCT4_19829295_ChIP-Seq_ESCs_Human0.97164518
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.95666620
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95427463
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.95356302
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95089510
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.95062977
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94670160
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93978167
164P300_18555785_Chip-Seq_ESCs_Mouse0.93872749
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93526739
166ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91052744
167SOX9_26525672_Chip-Seq_HEART_Mouse0.91045598
168TAF15_26573619_Chip-Seq_HEK293_Human0.90681656
169RNF2_27304074_Chip-Seq_NSC_Mouse0.89990913
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.89905365
171PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88338082
172NFYB_21822215_ChIP-Seq_K562_Human0.87679881
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87484272
174STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86901237
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.85643076
176SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85192691
177SOX2_21211035_ChIP-Seq_LN229_Human0.84081930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07133967
2MP0001929_abnormal_gametogenesis5.60969288
3MP0008877_abnormal_DNA_methylation4.20913175
4MP0002210_abnormal_sex_determination3.47689876
5MP0002161_abnormal_fertility/fecundity3.33388772
6MP0001145_abnormal_male_reproductive2.96964632
7MP0005670_abnormal_white_adipose2.87432417
8MP0000678_abnormal_parathyroid_gland2.67218197
9MP0000653_abnormal_sex_gland2.57667921
10MP0002653_abnormal_ependyma_morphology2.32430057
11MP0002138_abnormal_hepatobiliary_system2.28064616
12MP0001348_abnormal_lacrimal_gland2.15671589
13MP0005410_abnormal_fertilization16.3231183
14MP0002249_abnormal_larynx_morphology1.98212653
15MP0005248_abnormal_Harderian_gland1.88577766
16MP0005423_abnormal_somatic_nervous1.86550876
17MP0003136_yellow_coat_color1.67989676
18MP0002160_abnormal_reproductive_system1.67574990
19MP0002127_abnormal_cardiovascular_syste1.57417225
20MP0002822_catalepsy1.52034914
21MP0004859_abnormal_synaptic_plasticity1.50418093
22MP0003646_muscle_fatigue1.45209045
23MP0001486_abnormal_startle_reflex1.42834529
24MP0004233_abnormal_muscle_weight1.39907730
25MP0005623_abnormal_meninges_morphology1.32772498
26MP0005395_other_phenotype1.31778678
27MP0000049_abnormal_middle_ear1.29236300
28MP0008004_abnormal_stomach_pH1.28502535
29MP0008058_abnormal_DNA_repair1.27728193
30MP0001485_abnormal_pinna_reflex1.22266887
31MP0004510_myositis1.15909339
32MP0009053_abnormal_anal_canal1.15109656
33MP0005367_renal/urinary_system_phenotyp1.13698293
34MP0000516_abnormal_urinary_system1.13698293
35MP0000026_abnormal_inner_ear1.10941013
36MP0001765_abnormal_ion_homeostasis1.10405664
37MP0005310_abnormal_salivary_gland1.09880475
38MP0002282_abnormal_trachea_morphology1.04019128
39MP0000681_abnormal_thyroid_gland1.01624158
40MP0001963_abnormal_hearing_physiology1.01187915
41MP0005379_endocrine/exocrine_gland_phen0.99955406
42MP0002735_abnormal_chemical_nociception0.98971691
43MP0002234_abnormal_pharynx_morphology0.98224176
44MP0005647_abnormal_sex_gland0.92866272
45MP0000955_abnormal_spinal_cord0.90505876
46MP0001984_abnormal_olfaction0.90465357
47MP0001879_abnormal_lymphatic_vessel0.90076572
48MP0005389_reproductive_system_phenotype0.90057307
49MP0002229_neurodegeneration0.89368289
50MP0005499_abnormal_olfactory_system0.88386533
51MP0005394_taste/olfaction_phenotype0.88386533
52MP0005360_urolithiasis0.87107412
53MP0001905_abnormal_dopamine_level0.86995738
54MP0009046_muscle_twitch0.85994316
55MP0010094_abnormal_chromosome_stability0.83256949
56MP0003111_abnormal_nucleus_morphology0.82286413
57MP0006292_abnormal_olfactory_placode0.81714034
58MP0008995_early_reproductive_senescence0.79563480
59MP0003315_abnormal_perineum_morphology0.78280017
60MP0009745_abnormal_behavioral_response0.77788270
61MP0003632_abnormal_nervous_system0.74193556
62MP0002557_abnormal_social/conspecific_i0.73436187
63MP0003878_abnormal_ear_physiology0.71212852
64MP0005377_hearing/vestibular/ear_phenot0.71212852
65MP0005636_abnormal_mineral_homeostasis0.67584840
66MP0002102_abnormal_ear_morphology0.67554343
67MP0002067_abnormal_sensory_capabilities0.67230210
68MP0002733_abnormal_thermal_nociception0.66603122
69MP0002572_abnormal_emotion/affect_behav0.63259525
70MP0002272_abnormal_nervous_system0.62834693
71MP0003786_premature_aging0.60420577
72MP0004085_abnormal_heartbeat0.60118288
73MP0003011_delayed_dark_adaptation0.59314722
74MP0004036_abnormal_muscle_relaxation0.58806128
75MP0001970_abnormal_pain_threshold0.57428518
76MP0003115_abnormal_respiratory_system0.57226495
77MP0008057_abnormal_DNA_replication0.56222518
78MP0000358_abnormal_cell_content/0.55793366
79MP0001666_abnormal_nutrient_absorption0.55342738
80MP0005397_hematopoietic_system_phenotyp0.55184262
81MP0001545_abnormal_hematopoietic_system0.55184262
82MP0002269_muscular_atrophy0.54307812
83MP0001764_abnormal_homeostasis0.54281513
84MP0003699_abnormal_female_reproductive0.54066908
85MP0001501_abnormal_sleep_pattern0.53764671
86MP0003385_abnormal_body_wall0.51722413
87MP0003329_amyloid_beta_deposits0.51609507
88MP0000733_abnormal_muscle_development0.50552209
89MP0001324_abnormal_eye_pigmentation0.50431854
90MP0008569_lethality_at_weaning0.49620571
91MP0000631_abnormal_neuroendocrine_gland0.49397746
92MP0005666_abnormal_adipose_tissue0.49299178
93MP0006036_abnormal_mitochondrial_physio0.48762283
94MP0001529_abnormal_vocalization0.48294114
95MP0010368_abnormal_lymphatic_system0.47884319
96MP0000470_abnormal_stomach_morphology0.47845243
97MP0003119_abnormal_digestive_system0.47643885
98MP0003635_abnormal_synaptic_transmissio0.46829520
99MP0009697_abnormal_copulation0.46781884
100MP0001293_anophthalmia0.46624629
101MP0003787_abnormal_imprinting0.46542241
102MP0005451_abnormal_body_composition0.46501558
103MP0003959_abnormal_lean_body0.46374874
104MP0000566_synostosis0.43742578
105MP0001730_embryonic_growth_arrest0.43656351
106MP0004019_abnormal_vitamin_homeostasis0.43477578
107MP0009278_abnormal_bone_marrow0.40625977
108MP0002928_abnormal_bile_duct0.38319491
109MP0003879_abnormal_hair_cell0.37645335
110MP0005551_abnormal_eye_electrophysiolog0.37303040
111MP0005253_abnormal_eye_physiology0.36995052
112MP0003077_abnormal_cell_cycle0.35943952
113MP0006035_abnormal_mitochondrial_morpho0.35603081
114MP0008007_abnormal_cellular_replicative0.35450210
115MP0001119_abnormal_female_reproductive0.35332461
116MP0009115_abnormal_fat_cell0.35117781
117MP0001661_extended_life_span0.34808059
118MP0010307_abnormal_tumor_latency0.33336950
119MP0003950_abnormal_plasma_membrane0.32566415
120MP0002736_abnormal_nociception_after0.31961207
121MP0005391_vision/eye_phenotype0.31148165
122MP0003693_abnormal_embryo_hatching0.31140686
123MP0000534_abnormal_ureter_morphology0.30083162
124MP0001727_abnormal_embryo_implantation0.27113270
125MP0002169_no_abnormal_phenotype0.25527203
126MP0000313_abnormal_cell_death0.25305019
127MP0002873_normal_phenotype0.25241021
128MP0002971_abnormal_brown_adipose0.24911323
129MP0001672_abnormal_embryogenesis/_devel0.24544778
130MP0005380_embryogenesis_phenotype0.24544778
131MP0002132_abnormal_respiratory_system0.24532295
132MP0000604_amyloidosis0.23061495
133MP0004084_abnormal_cardiac_muscle0.23049452
134MP0002139_abnormal_hepatobiliary_system0.22108471
135MP0003861_abnormal_nervous_system0.21877968
136MP0003718_maternal_effect0.20549745
137MP0003633_abnormal_nervous_system0.20506575
138MP0004957_abnormal_blastocyst_morpholog0.19949099
139MP0001697_abnormal_embryo_size0.19634772
140MP0004133_heterotaxia0.19633096
141MP0004811_abnormal_neuron_physiology0.19396459
142MP0002084_abnormal_developmental_patter0.19294448
143MP0004808_abnormal_hematopoietic_stem0.19003427
144MP0005319_abnormal_enzyme/_coenzyme0.18544905
145MP0002080_prenatal_lethality0.18417736
146MP0003984_embryonic_growth_retardation0.18269788
147MP0002092_abnormal_eye_morphology0.17872513
148MP0000569_abnormal_digit_pigmentation0.17717126
149MP0002152_abnormal_brain_morphology0.17694155
150MP0003948_abnormal_gas_homeostasis0.17303024
151MP0000001_mammalian_phenotype0.17187728
152MP0003631_nervous_system_phenotype0.16391671
153MP0004145_abnormal_muscle_electrophysio0.16233482
154MP0008932_abnormal_embryonic_tissue0.16210463
155MP0003942_abnormal_urinary_system0.16015007
156MP0002088_abnormal_embryonic_growth/wei0.15893650
157MP0001968_abnormal_touch/_nociception0.14097674
158MP0003936_abnormal_reproductive_system0.13622005
159MP0004742_abnormal_vestibular_system0.13606476

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.50318628
2Abnormal respiratory motile cilium morphology (HP:0005938)9.50318628
3Abnormal respiratory motile cilium physiology (HP:0012261)9.46059966
4Abnormal ciliary motility (HP:0012262)7.59870937
5Rhinitis (HP:0012384)7.54856157
6Chronic bronchitis (HP:0004469)7.50813469
7Resting tremor (HP:0002322)6.84849614
8Infertility (HP:0000789)6.81431796
9Severe visual impairment (HP:0001141)6.64602859
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.28106199
11Nasal polyposis (HP:0100582)6.24304526
12Abnormality of the nasal mucosa (HP:0000433)5.10998564
13Male infertility (HP:0003251)4.71857475
14Attenuation of retinal blood vessels (HP:0007843)4.67716768
15Bony spicule pigmentary retinopathy (HP:0007737)4.59429241
16Bronchitis (HP:0012387)4.49789516
17Postural instability (HP:0002172)4.46237338
18Bronchiectasis (HP:0002110)4.36589648
19Nephronophthisis (HP:0000090)3.99773922
20Abnormal spermatogenesis (HP:0008669)3.78306605
21Abnormal rod and cone electroretinograms (HP:0008323)3.59423797
22Recurrent sinusitis (HP:0011108)3.52134888
23Hypoplastic ischia (HP:0003175)3.46920527
24Potter facies (HP:0002009)3.41469648
25Facial shape deformation (HP:0011334)3.41469648
26Abnormality of the ischium (HP:0003174)3.28638313
27Recurrent otitis media (HP:0000403)3.25356920
28Abnormality of the aortic arch (HP:0012303)3.21262647
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.14888132
30Abnormality of macular pigmentation (HP:0008002)3.12733917
31Chronic hepatic failure (HP:0100626)3.01729818
32Abnormality of the renal medulla (HP:0100957)2.97577276
33Hyperkalemia (HP:0002153)2.94578626
34Impulsivity (HP:0100710)2.83445767
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.80551930
36Medial flaring of the eyebrow (HP:0010747)2.65069356
37Molar tooth sign on MRI (HP:0002419)2.62095664
38Abnormality of midbrain morphology (HP:0002418)2.62095664
39Tubulointerstitial nephritis (HP:0001970)2.61873144
40Enlarged epiphyses (HP:0010580)2.59835047
41Unilateral renal agenesis (HP:0000122)2.58498369
42Hypophosphatemic rickets (HP:0004912)2.56221967
43Generalized aminoaciduria (HP:0002909)2.55470289
44Hyperthyroidism (HP:0000836)2.49293541
45Recurrent bronchitis (HP:0002837)2.49106880
46Azoospermia (HP:0000027)2.48645451
47Periauricular skin pits (HP:0100277)2.42976027
48Preauricular pit (HP:0004467)2.42976027
49Tubular atrophy (HP:0000092)2.41352504
50Abnormality of the parathyroid morphology (HP:0011766)2.37930790
51Hypoplasia of the thymus (HP:0000778)2.36822303
52Optic nerve hypoplasia (HP:0000609)2.34727371
53Cone-rod dystrophy (HP:0000548)2.33735844
54Polyuria (HP:0000103)2.33404592
55Transposition of the great arteries (HP:0001669)2.27281437
56Abnormal connection of the cardiac segments (HP:0011545)2.27281437
57Abnormal ventriculo-arterial connection (HP:0011563)2.27281437
58Hypoplastic left heart (HP:0004383)2.27247468
59Gonadotropin excess (HP:0000837)2.24963824
60Tubulointerstitial abnormality (HP:0001969)2.22142895
61Amblyopia (HP:0000646)2.18943041
62Sensory axonal neuropathy (HP:0003390)2.18653508
63Renal salt wasting (HP:0000127)2.12236842
64Progressive cerebellar ataxia (HP:0002073)2.10200725
65Hypochromic microcytic anemia (HP:0004840)2.07902493
66Atelectasis (HP:0100750)2.06231015
67Truncal obesity (HP:0001956)2.05348067
68Hypoparathyroidism (HP:0000829)2.05261963
69Hypoalphalipoproteinemia (HP:0003233)2.04974671
70Abnormality of the pubic bones (HP:0003172)2.03876489
71Bowel incontinence (HP:0002607)2.02796998
72Skin pits (HP:0100276)2.02198395
73Myokymia (HP:0002411)2.00945096
74Absent/shortened dynein arms (HP:0200106)13.6510918
75Dynein arm defect of respiratory motile cilia (HP:0012255)13.6510918
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1727073
77Abnormality of potassium homeostasis (HP:0011042)1.99167884
78Dyschromatopsia (HP:0007641)1.96203270
79Hypoplastic heart (HP:0001961)1.95791063
80Bulbous nose (HP:0000414)1.95634883
81Osteomalacia (HP:0002749)1.95585806
82Epiphyseal dysplasia (HP:0002656)1.94581324
83Truncus arteriosus (HP:0001660)1.93538622
84Tetany (HP:0001281)1.92966157
85Abnormal gallbladder physiology (HP:0012438)1.92510002
86Cholecystitis (HP:0001082)1.92510002
87Abnormal large intestine physiology (HP:0012700)1.92292359
88Exocrine pancreatic insufficiency (HP:0001738)1.91989877
89Abnormality of dental color (HP:0011073)1.91527914
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90234009
91Mixed hearing impairment (HP:0000410)1.87642641
92Spastic tetraparesis (HP:0001285)1.86661767
93Hyponatremia (HP:0002902)1.84994305
94Hypoplasia of the uterus (HP:0000013)1.82683987
95Congenital sensorineural hearing impairment (HP:0008527)1.81924869
96Bradykinesia (HP:0002067)1.81657780
97Recurrent corneal erosions (HP:0000495)1.80287254
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79875951
99Anterior segment dysgenesis (HP:0007700)1.79283229
100Decreased central vision (HP:0007663)1.78640582
101Tubulointerstitial fibrosis (HP:0005576)1.76943748
102Type II lissencephaly (HP:0007260)1.76695519
103Postaxial foot polydactyly (HP:0001830)1.75140112
104Flattened epiphyses (HP:0003071)1.71823222
105Congenital malformation of the right heart (HP:0011723)1.71040178
106Double outlet right ventricle (HP:0001719)1.71040178
107Choroideremia (HP:0001139)1.70900120
108Stage 5 chronic kidney disease (HP:0003774)1.68584366
109Bundle branch block (HP:0011710)1.66601376
110Abnormality of the renal cortex (HP:0011035)1.65045250
111Congenital hepatic fibrosis (HP:0002612)1.63926622
112Polydipsia (HP:0001959)1.59140063
113Abnormal drinking behavior (HP:0030082)1.59140063
114Abnormality of renal excretion (HP:0011036)1.59135107
115Congenital primary aphakia (HP:0007707)1.57524672
116Gait imbalance (HP:0002141)1.56717064
117Taurodontia (HP:0000679)1.56580852
118Abnormality of permanent molar morphology (HP:0011071)1.56580852
119Abnormality of the dental root (HP:0006486)1.56580852
120Oculomotor apraxia (HP:0000657)1.54296717
121Aplasia/Hypoplasia of the lens (HP:0008063)1.53502743
122Heterotopia (HP:0002282)1.52891328
123Pancreatic fibrosis (HP:0100732)1.51051449
124Facial cleft (HP:0002006)1.49999551
125Chronic sinusitis (HP:0011109)1.47233772
126Abnormality of molar (HP:0011077)1.45188425
127Abnormality of molar morphology (HP:0011070)1.45188425
128Fibular hypoplasia (HP:0003038)1.45170130
129Cystic liver disease (HP:0006706)1.44508178
130Abnormal biliary tract physiology (HP:0012439)1.44299858
131Bile duct proliferation (HP:0001408)1.44299858
132Abnormality of the dental pulp (HP:0006479)1.43960974
133Asymmetric septal hypertrophy (HP:0001670)1.42670369
134Short ribs (HP:0000773)1.42453572
135Hemorrhage of the eye (HP:0011885)1.42319675
136Postaxial hand polydactyly (HP:0001162)1.41898020
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40463207
138Absent epiphyses (HP:0010577)1.40463207
139Bell-shaped thorax (HP:0001591)1.38414491
140Renal dysplasia (HP:0000110)1.33913814
141Nephrogenic diabetes insipidus (HP:0009806)1.33074893
142Abnormality of the lower motor neuron (HP:0002366)1.32669341
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.30728637
144Constricted visual fields (HP:0001133)1.25877232
145Easy fatigability (HP:0003388)1.25428191
146Abnormal urine output (HP:0012590)1.24854439
147Amyotrophic lateral sclerosis (HP:0007354)1.23724802
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23305270
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.23284043
150Microglossia (HP:0000171)1.22561379
151Neurofibrillary tangles (HP:0002185)1.22127117
152Poor coordination (HP:0002370)1.21158139
153Abnormality of dentin (HP:0010299)1.21019868
154True hermaphroditism (HP:0010459)1.21000169
155Abnormality of saccadic eye movements (HP:0000570)1.20351807
156Vaginal atresia (HP:0000148)1.20018250
157Supernumerary spleens (HP:0009799)1.18919488
158Genital tract atresia (HP:0001827)1.18604488
159Abnormality of the neuromuscular junction (HP:0003398)1.17314299
160Fatigable weakness (HP:0003473)1.17314299
161Broad distal phalanx of finger (HP:0009836)1.15630214
162Cerebellar dysplasia (HP:0007033)1.15584361
163Short nail (HP:0001799)1.15178349
164Abnormality of ocular smooth pursuit (HP:0000617)1.13189458
165Nephropathy (HP:0000112)1.13132319
166Pancreatic cysts (HP:0001737)1.12075720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.65554140
2PDK48.65554140
3PDK25.64957309
4TESK15.62198575
5PRKD34.46659067
6DDR24.25461618
7ICK3.91492753
8INSRR3.36630527
9BRD43.03264602
10PIM22.77020438
11LATS22.51702206
12BMPR1B2.45265554
13MAP4K22.30406896
14PLK22.27796989
15PTK2B2.02127679
16PNCK1.93579965
17WNK41.92721564
18STK391.86347709
19MAP3K91.80417772
20NEK21.74363419
21STK381.72324792
22CDK71.62455642
23TLK11.53717896
24DYRK1B1.34409867
25ADRBK21.32262403
26MST1R1.31125829
27CDK81.22395154
28PDK11.16772379
29TAF11.01946436
30DYRK31.00872787
31ARAF0.98019951
32CDK90.96982683
33LATS10.93727622
34TGFBR10.92280296
35TTK0.89745982
36IRAK10.88396982
37PLK40.86217672
38PINK10.85557104
39CCNB10.83071543
40WEE10.79574749
41KSR20.79464508
42EIF2AK30.75826265
43CHEK20.74521874
44TYRO30.72229030
45UHMK10.71950538
46TESK20.71460505
47STK30.71258179
48NTRK30.70845925
49MOS0.70568432
50PDPK10.69549281
51PIK3CG0.69285763
52BCKDK0.68487112
53MAPK150.65737697
54WNK10.63570903
55BUB10.62788907
56PASK0.62330780
57RIPK40.60871572
58RPS6KA50.60068001
59CDK30.56039346
60LMTK20.55010991
61STK38L0.54402822
62IRAK20.52574153
63MAP2K60.51632052
64ABL20.51364901
65MAP3K10.51336237
66CAMK10.49104674
67MAPK10.48738956
68CAMK1D0.48734421
69MAP2K70.48639317
70BRSK20.48210176
71DAPK30.47297394
72ROCK10.45695761
73EEF2K0.45131244
74PRKAA20.44868943
75CHEK10.43776136
76DYRK20.42175200
77PAK10.41048824
78SGK4940.40638018
79SGK2230.40638018
80MAP3K40.39180406
81RPS6KC10.37439421
82RPS6KL10.37439421
83PLK10.37120347
84PRKCG0.35761904
85SIK20.35033493
86MAP3K80.33517439
87MYLK0.33206484
88MUSK0.32939945
89RPS6KA60.32777366
90MET0.32046395
91CSNK1A1L0.31978420
92NTRK20.30768549
93ATR0.30753248
94CAMK1G0.30189395
95RPS6KA20.30115678
96MAP3K20.29899103
97ATM0.29436085
98BRSK10.28725529
99MAPK140.25036969
100MAP3K110.24610406
101PAK20.24588306
102MTOR0.22866753
103MAPK100.22499628
104TAOK30.21703351
105FRK0.21552137
106NEK60.20726198
107BRAF0.20009038
108PRKAA10.19644961
109CAMKK10.19516284
110ZAK0.18665168
111PAK40.18399281
112MAPKAPK50.17649190
113MAP3K100.15842324
114CDC70.14956717
115PRKCZ0.14793276
116MARK20.14627418
117AKT30.14024068
118CSNK2A10.13478799
119CDK150.10819265
120RPS6KB10.10501422
121MARK30.10365248
122AURKA0.09009007
123PIM10.08907346
124CSNK2A20.07991715
125CDK180.07980867
126CDK20.07703691
127CDK11A0.07204421
128WNK30.06334249
129CDK10.06248877
130STK160.06150270
131PLK30.06115255
132PRKG20.05844816
133GSK3B0.05616220
134RPS6KA10.05018561
135CDK140.04727717
136PKN10.04512767
137PRKACG0.04512432
138PRKCQ0.03372524
139EIF2AK10.03224418
140STK100.02811418
141PRKG10.02626030
142CDK40.02323841
143AURKB0.02074418
144MAPK80.01911977
145MARK10.01402276
146CSNK1D0.01341396
147CDK60.01043409
148CSNK1E0.01002524
149PRKCD0.00970804
150STK110.00949129
151MAP3K50.00073464
152PRKACB-0.0110877
153CDK12-0.0088221
154CAMK2A-0.0050299
155PRKCB-0.0050059
156PRKCA-0.0004077

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.76212377
2Vitamin B6 metabolism_Homo sapiens_hsa007505.46552357
3Fatty acid biosynthesis_Homo sapiens_hsa000614.17082447
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.16003344
5Olfactory transduction_Homo sapiens_hsa047403.66755818
6Pyruvate metabolism_Homo sapiens_hsa006203.38005242
7Butanoate metabolism_Homo sapiens_hsa006502.92064372
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86386601
9Linoleic acid metabolism_Homo sapiens_hsa005912.82791203
10Basal transcription factors_Homo sapiens_hsa030222.75219740
11Propanoate metabolism_Homo sapiens_hsa006402.69297310
12Glucagon signaling pathway_Homo sapiens_hsa049222.42283779
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.32669181
14Sulfur relay system_Homo sapiens_hsa041222.20182730
15Pentose phosphate pathway_Homo sapiens_hsa000302.15838089
16Selenocompound metabolism_Homo sapiens_hsa004502.06627690
17Arginine biosynthesis_Homo sapiens_hsa002202.03500159
18Phenylalanine metabolism_Homo sapiens_hsa003602.00284841
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99116876
20Glycerolipid metabolism_Homo sapiens_hsa005611.97429171
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91734337
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88549671
23Oocyte meiosis_Homo sapiens_hsa041141.87492304
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.87259813
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.81578000
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74921636
27PPAR signaling pathway_Homo sapiens_hsa033201.73488267
28Fructose and mannose metabolism_Homo sapiens_hsa000511.68981104
29Arginine and proline metabolism_Homo sapiens_hsa003301.68010356
30Fanconi anemia pathway_Homo sapiens_hsa034601.60967591
31Mineral absorption_Homo sapiens_hsa049781.48761664
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.44015594
33Carbon metabolism_Homo sapiens_hsa012001.42858712
34RNA transport_Homo sapiens_hsa030131.40752473
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38730711
36Amphetamine addiction_Homo sapiens_hsa050311.35758482
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34832095
38Fat digestion and absorption_Homo sapiens_hsa049751.33447714
39Ether lipid metabolism_Homo sapiens_hsa005651.29014526
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.26348427
41Tyrosine metabolism_Homo sapiens_hsa003501.21608817
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.20635832
43Retinol metabolism_Homo sapiens_hsa008301.20531162
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18532943
45Fatty acid metabolism_Homo sapiens_hsa012121.17728225
46Cardiac muscle contraction_Homo sapiens_hsa042601.17050775
47Gap junction_Homo sapiens_hsa045401.14565550
48Dorso-ventral axis formation_Homo sapiens_hsa043201.12234435
49Fatty acid degradation_Homo sapiens_hsa000711.11003511
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10352077
51Nicotine addiction_Homo sapiens_hsa050331.08116217
52Huntingtons disease_Homo sapiens_hsa050161.06629125
53Glutathione metabolism_Homo sapiens_hsa004801.05036203
54mRNA surveillance pathway_Homo sapiens_hsa030151.04960523
55Antigen processing and presentation_Homo sapiens_hsa046121.04162130
56Collecting duct acid secretion_Homo sapiens_hsa049661.03352194
57Circadian rhythm_Homo sapiens_hsa047101.02569049
58* Purine metabolism_Homo sapiens_hsa002301.02134455
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00305059
60Nitrogen metabolism_Homo sapiens_hsa009100.99831880
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98946067
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98766207
63Biosynthesis of amino acids_Homo sapiens_hsa012300.97830701
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92861577
65Type II diabetes mellitus_Homo sapiens_hsa049300.90882395
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89056899
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86841379
68Renin secretion_Homo sapiens_hsa049240.85531445
69Pyrimidine metabolism_Homo sapiens_hsa002400.82503798
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81934803
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79395291
72Arachidonic acid metabolism_Homo sapiens_hsa005900.79198636
73Hedgehog signaling pathway_Homo sapiens_hsa043400.74002393
74Caffeine metabolism_Homo sapiens_hsa002320.72520457
75Renin-angiotensin system_Homo sapiens_hsa046140.69676683
76Chemical carcinogenesis_Homo sapiens_hsa052040.67664456
77Proteasome_Homo sapiens_hsa030500.66902764
78Morphine addiction_Homo sapiens_hsa050320.66449132
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.63192839
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.62720666
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62646279
82Phototransduction_Homo sapiens_hsa047440.61293953
83Insulin secretion_Homo sapiens_hsa049110.60016568
84Systemic lupus erythematosus_Homo sapiens_hsa053220.58650915
85Estrogen signaling pathway_Homo sapiens_hsa049150.55958830
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55661231
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55391870
88Complement and coagulation cascades_Homo sapiens_hsa046100.54824148
89Long-term potentiation_Homo sapiens_hsa047200.54294394
90Thyroid hormone synthesis_Homo sapiens_hsa049180.54262409
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54135216
92Bile secretion_Homo sapiens_hsa049760.53920907
93Circadian entrainment_Homo sapiens_hsa047130.52944428
94Type I diabetes mellitus_Homo sapiens_hsa049400.52449858
95Autoimmune thyroid disease_Homo sapiens_hsa053200.51619849
96Legionellosis_Homo sapiens_hsa051340.50883929
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50624555
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49839608
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49721748
100beta-Alanine metabolism_Homo sapiens_hsa004100.49053471
101Inositol phosphate metabolism_Homo sapiens_hsa005620.48605274
102Allograft rejection_Homo sapiens_hsa053300.47755476
103* Metabolic pathways_Homo sapiens_hsa011000.45767813
104Cholinergic synapse_Homo sapiens_hsa047250.45551498
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.42064659
106Pancreatic secretion_Homo sapiens_hsa049720.41707323
107Calcium signaling pathway_Homo sapiens_hsa040200.41351851
108Protein digestion and absorption_Homo sapiens_hsa049740.41182546
109Graft-versus-host disease_Homo sapiens_hsa053320.41047610
110Viral myocarditis_Homo sapiens_hsa054160.40739338
111MAPK signaling pathway_Homo sapiens_hsa040100.40557550
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39779591
113GABAergic synapse_Homo sapiens_hsa047270.39565572
114Synaptic vesicle cycle_Homo sapiens_hsa047210.39178657
115ABC transporters_Homo sapiens_hsa020100.38268926
116Regulation of autophagy_Homo sapiens_hsa041400.38063365
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37685613
118Cell cycle_Homo sapiens_hsa041100.36960315
119AMPK signaling pathway_Homo sapiens_hsa041520.36435674
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35977699
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35659614
122Viral carcinogenesis_Homo sapiens_hsa052030.35466926
123Endocytosis_Homo sapiens_hsa041440.35196471
124Oxytocin signaling pathway_Homo sapiens_hsa049210.33868559
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33458414
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33328662
127DNA replication_Homo sapiens_hsa030300.32463143
128Salivary secretion_Homo sapiens_hsa049700.30299393
129FoxO signaling pathway_Homo sapiens_hsa040680.29761301
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.27062338
131Taste transduction_Homo sapiens_hsa047420.27053412
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25749660
133Vitamin digestion and absorption_Homo sapiens_hsa049770.24780306
134Sulfur metabolism_Homo sapiens_hsa009200.24757973
135Epstein-Barr virus infection_Homo sapiens_hsa051690.22752850
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19495176
137VEGF signaling pathway_Homo sapiens_hsa043700.18764334
138Gastric acid secretion_Homo sapiens_hsa049710.18747229
139Homologous recombination_Homo sapiens_hsa034400.18459624
140Alcoholism_Homo sapiens_hsa050340.16886492
141cAMP signaling pathway_Homo sapiens_hsa040240.16064358
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15892380
143N-Glycan biosynthesis_Homo sapiens_hsa005100.14879132
144RNA degradation_Homo sapiens_hsa030180.13578566

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