ALMS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.59739522
2nuclear pore organization (GO:0006999)5.05451520
3mitotic sister chromatid cohesion (GO:0007064)4.88170465
4cilium or flagellum-dependent cell motility (GO:0001539)4.80280868
5establishment of protein localization to Golgi (GO:0072600)4.68187852
6microtubule depolymerization (GO:0007019)4.61083874
7microtubule polymerization or depolymerization (GO:0031109)4.58617858
8piRNA metabolic process (GO:0034587)4.49393282
9protein targeting to Golgi (GO:0000042)4.33585549
10male meiosis (GO:0007140)4.31018091
11pore complex assembly (GO:0046931)4.29356510
12regulation of centriole replication (GO:0046599)4.25964376
13retrograde transport, vesicle recycling within Golgi (GO:0000301)4.25894105
14motile cilium assembly (GO:0044458)4.10482896
15kinetochore organization (GO:0051383)4.08042242
16acrosome reaction (GO:0007340)3.98894708
17meiotic chromosome segregation (GO:0045132)3.95300171
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91077006
19axonemal dynein complex assembly (GO:0070286)3.87340662
20regulation of histone H3-K9 methylation (GO:0051570)3.87008253
21synaptonemal complex assembly (GO:0007130)3.85834195
22regulation of DNA endoreduplication (GO:0032875)3.83975529
23nucleus organization (GO:0006997)3.81412741
24histone H3-K9 demethylation (GO:0033169)3.77920801
25protein polyglutamylation (GO:0018095)3.70187462
26epithelial cilium movement (GO:0003351)3.68720506
27synaptonemal complex organization (GO:0070193)3.68555884
28single strand break repair (GO:0000012)3.68380771
29DNA methylation involved in gamete generation (GO:0043046)3.60883309
30centriole assembly (GO:0098534)3.59143005
31centriole replication (GO:0007099)3.56145890
32sister chromatid cohesion (GO:0007062)3.55436025
33ventricular system development (GO:0021591)3.55124430
34chromosome organization involved in meiosis (GO:0070192)3.51314766
35retinal rod cell development (GO:0046548)3.48834382
36mitotic chromosome condensation (GO:0007076)3.47913832
37microtubule severing (GO:0051013)3.46092700
38histone H3-K9 methylation (GO:0051567)3.43258313
39interkinetic nuclear migration (GO:0022027)3.43210553
40histone H3-K36 demethylation (GO:0070544)3.42460300
41cilium movement (GO:0003341)3.42237601
42spermatid nucleus differentiation (GO:0007289)3.42028319
43kinetochore assembly (GO:0051382)3.40862807
44protein K6-linked ubiquitination (GO:0085020)3.35834136
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33808922
46acrosome assembly (GO:0001675)3.30633335
47sister chromatid segregation (GO:0000819)3.30464376
48male meiosis I (GO:0007141)3.28892852
49embryonic retina morphogenesis in camera-type eye (GO:0060059)3.27621560
50meiotic nuclear division (GO:0007126)3.22590322
51retinal cone cell development (GO:0046549)3.21540291
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.20378287
53regulation of RNA export from nucleus (GO:0046831)3.18064257
54regulation of meiosis I (GO:0060631)3.17200034
55translesion synthesis (GO:0019985)3.16985179
56paraxial mesoderm development (GO:0048339)3.16657274
57replicative senescence (GO:0090399)3.15454136
58fusion of sperm to egg plasma membrane (GO:0007342)3.15221124
59centrosome duplication (GO:0051298)3.15044926
60reciprocal DNA recombination (GO:0035825)3.14685377
61reciprocal meiotic recombination (GO:0007131)3.14685377
62DNA replication-dependent nucleosome assembly (GO:0006335)3.13867234
63DNA replication-dependent nucleosome organization (GO:0034723)3.13867234
64protein K48-linked deubiquitination (GO:0071108)3.12563281
65sperm-egg recognition (GO:0035036)3.11448330
66genitalia morphogenesis (GO:0035112)3.10488087
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.10470634
68gene silencing by RNA (GO:0031047)3.08282581
69DNA synthesis involved in DNA repair (GO:0000731)3.07645813
70histone exchange (GO:0043486)3.07421566
71DNA packaging (GO:0006323)3.05632436
72negative regulation of inclusion body assembly (GO:0090084)3.05591001
73peptidyl-lysine dimethylation (GO:0018027)3.05445514
74sperm capacitation (GO:0048240)3.05320078
75microtubule nucleation (GO:0007020)3.05318595
76sperm motility (GO:0030317)3.05201512
77protein localization to Golgi apparatus (GO:0034067)3.03002323
78regulation of centrosome cycle (GO:0046605)3.02794061
79axoneme assembly (GO:0035082)3.02517183
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.01384001
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01384001
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01384001
83mitotic sister chromatid segregation (GO:0000070)3.00193658
84cytoplasmic mRNA processing body assembly (GO:0033962)2.99371264
85meiotic cell cycle process (GO:1903046)2.99078855
86histone lysine demethylation (GO:0070076)2.97393682
87regulation of centrosome duplication (GO:0010824)2.97162009
88negative regulation of DNA repair (GO:0045738)2.97134283
89negative regulation of histone methylation (GO:0031061)2.96438523
90chromatin remodeling at centromere (GO:0031055)2.96088524
91protein localization to chromosome, centromeric region (GO:0071459)2.95854152
92binding of sperm to zona pellucida (GO:0007339)2.95401942
93pre-miRNA processing (GO:0031054)2.93877726
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.93792472
95intra-S DNA damage checkpoint (GO:0031573)2.93656608
96chromatin silencing (GO:0006342)2.93254988
97protein localization to kinetochore (GO:0034501)2.91921669
98spermatid development (GO:0007286)2.91727577
99DNA alkylation (GO:0006305)2.89730382
100DNA methylation (GO:0006306)2.89730382
101intraciliary transport (GO:0042073)2.89439007
102mismatch repair (GO:0006298)2.89309409
103monoubiquitinated protein deubiquitination (GO:0035520)2.88749632
104musculoskeletal movement (GO:0050881)2.88413322
105multicellular organismal movement (GO:0050879)2.88413322
106meiotic cell cycle (GO:0051321)2.87842106
107regulation of translation, ncRNA-mediated (GO:0045974)2.87722091
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87722091
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.87722091
110chromosome condensation (GO:0030261)2.87711838
111histone H3-K9 modification (GO:0061647)2.86296268
112multicellular organism reproduction (GO:0032504)2.86139371
113Golgi to endosome transport (GO:0006895)2.85800671
114dosage compensation (GO:0007549)2.85294561
115DNA conformation change (GO:0071103)2.84542661
116regulation of sister chromatid cohesion (GO:0007063)2.83460782
117male gamete generation (GO:0048232)2.83292603
118DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83216654
119mitotic nuclear envelope disassembly (GO:0007077)2.83001947
120spermatogenesis (GO:0007283)2.82570183
121resolution of meiotic recombination intermediates (GO:0000712)2.82302469
122nucleus localization (GO:0051647)2.80129772
123metaphase plate congression (GO:0051310)2.79197147
124regulation of double-strand break repair (GO:2000779)2.78924829
125histone demethylation (GO:0016577)2.78561784
126CENP-A containing nucleosome assembly (GO:0034080)2.76558158
127attachment of spindle microtubules to kinetochore (GO:0008608)2.76317247
128regulation of helicase activity (GO:0051095)2.75664303
129protein localization to chromosome (GO:0034502)2.75651685
130DNA replication initiation (GO:0006270)2.75532847
131DNA topological change (GO:0006265)2.74809946
132DNA replication-independent nucleosome assembly (GO:0006336)2.74602084
133DNA replication-independent nucleosome organization (GO:0034724)2.74602084
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74482573
135regulation of chromosome segregation (GO:0051983)2.74347476
136DNA damage response, signal transduction resulting in transcription (GO:0042772)2.74079434
137DNA geometric change (GO:0032392)2.73602270
138protein-DNA complex disassembly (GO:0032986)2.71953685
139nucleosome disassembly (GO:0006337)2.71953685
140gamete generation (GO:0007276)2.70645974
141embryonic camera-type eye morphogenesis (GO:0048596)2.68994999
142regulation of gene silencing by RNA (GO:0060966)2.67046015
143regulation of posttranscriptional gene silencing (GO:0060147)2.67046015
144regulation of gene silencing by miRNA (GO:0060964)2.67046015
145histone lysine methylation (GO:0034968)2.63406681
146phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63270422
147peptidyl-lysine trimethylation (GO:0018023)2.61116080
148glomerular epithelial cell development (GO:0072310)2.56427073
149histone mRNA catabolic process (GO:0071044)2.56319608
150oocyte development (GO:0048599)2.55996055
151NLS-bearing protein import into nucleus (GO:0006607)2.55385411
152germ cell development (GO:0007281)2.54926582
153microtubule bundle formation (GO:0001578)2.54269993
154glomerular visceral epithelial cell development (GO:0072015)2.54101015
155regulation of cilium movement (GO:0003352)2.53286294
156establishment of nucleus localization (GO:0040023)2.53157886
157microtubule anchoring (GO:0034453)2.53041152
158regulation of Rab GTPase activity (GO:0032313)2.52928900
159positive regulation of Rab GTPase activity (GO:0032851)2.52928900
160left/right axis specification (GO:0070986)2.52751752
161retina layer formation (GO:0010842)2.52042759
162regulation of gene silencing (GO:0060968)2.52037706
163microtubule organizing center organization (GO:0031023)2.51629383
164reproduction (GO:0000003)2.50360426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.67144472
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.40605372
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.15544656
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.10390928
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99269124
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.55237996
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36079695
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.97056607
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.62195208
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58560011
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33077947
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29162338
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25643493
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24318665
15AR_21572438_ChIP-Seq_LNCaP_Human2.07550148
16FUS_26573619_Chip-Seq_HEK293_Human2.05232628
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.01332860
18TAF15_26573619_Chip-Seq_HEK293_Human1.96813247
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91763763
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.88621860
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87132864
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.86688018
23CBP_20019798_ChIP-Seq_JUKART_Human1.86688018
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85430864
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.82929683
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78400608
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78142313
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74897182
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74265113
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.73412785
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.70187035
32IGF1R_20145208_ChIP-Seq_DFB_Human1.68692302
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.67307343
34* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66749238
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64688441
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64198413
37AHR_22903824_ChIP-Seq_MCF-7_Human1.63323929
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63276543
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60277106
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59775435
41EWS_26573619_Chip-Seq_HEK293_Human1.53108148
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52537048
43* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46814027
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45504057
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45318761
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42569534
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39635425
48AR_25329375_ChIP-Seq_VCAP_Human1.38641899
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.38101111
50DROSHA_22980978_ChIP-Seq_HELA_Human1.36882945
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36451221
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35807791
53EZH2_22144423_ChIP-Seq_EOC_Human1.34959624
54AR_21909140_ChIP-Seq_LNCAP_Human1.34727100
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32959214
56GBX2_23144817_ChIP-Seq_PC3_Human1.31223305
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.30065891
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29598872
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28902440
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.26785628
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25701115
62RUNX2_22187159_ChIP-Seq_PCA_Human1.25390682
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24883923
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24133506
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23695386
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23695386
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.23421918
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21803328
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.21385489
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20425277
71RNF2_27304074_Chip-Seq_NSC_Mouse1.20254639
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.20245729
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.19178110
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18371607
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16686111
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16406127
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15301553
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12361012
79ZNF274_21170338_ChIP-Seq_K562_Hela1.12337599
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.12122983
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12092110
82SOX9_26525672_Chip-Seq_HEART_Mouse1.11875990
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11861739
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.11291786
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.11091561
86NFYB_21822215_ChIP-Seq_K562_Human1.10037856
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09985846
88KDM2B_26808549_Chip-Seq_REH_Human1.09517376
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09465748
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.09365426
91* TCF4_23295773_ChIP-Seq_U87_Human1.09256455
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.07687037
93* AR_19668381_ChIP-Seq_PC3_Human1.07668574
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.07527191
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07021867
96TP53_18474530_ChIP-ChIP_U2OS_Human1.06535159
97P53_22387025_ChIP-Seq_ESCs_Mouse1.06177302
98STAT3_23295773_ChIP-Seq_U87_Human1.05985523
99P300_18555785_Chip-Seq_ESCs_Mouse1.04981624
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04356274
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.04355325
102TP53_16413492_ChIP-PET_HCT116_Human1.04132674
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03858826
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03106614
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03080279
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02268711
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01489076
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.01173165
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00872360
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.00329334
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00241881
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97804318
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97743337
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97618165
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.97326147
116GF1B_26923725_Chip-Seq_HPCs_Mouse0.96876162
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96636551
118CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96570835
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96251212
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.96102196
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95774503
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93329697
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92417540
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92406744
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92119225
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92119225
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92119225
128* SMAD4_21799915_ChIP-Seq_A2780_Human0.91974011
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91826291
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89916197
131NMYC_18555785_Chip-Seq_ESCs_Mouse0.89828998
132KLF4_18555785_Chip-Seq_ESCs_Mouse0.89194587
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.88133462
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.87249869
135ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86896352
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85639483
137P300_19829295_ChIP-Seq_ESCs_Human0.85606226
138ER_23166858_ChIP-Seq_MCF-7_Human0.84860264
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84028707
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82497035
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81613203
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.81532906
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80192593
144TBL1_22424771_ChIP-Seq_293T_Human0.79737478
145* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79487574
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78025717
147CTCF_18555785_Chip-Seq_ESCs_Mouse0.77735979
148TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77734623

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.97001274
2MP0010094_abnormal_chromosome_stability3.57288171
3MP0008057_abnormal_DNA_replication3.54047980
4MP0008058_abnormal_DNA_repair3.07545292
5MP0005410_abnormal_fertilization2.95378858
6MP0003111_abnormal_nucleus_morphology2.80979763
7MP0003787_abnormal_imprinting2.60989734
8MP0000566_synostosis2.43761659
9MP0000569_abnormal_digit_pigmentation2.41230026
10MP0003121_genomic_imprinting2.37415844
11MP0003693_abnormal_embryo_hatching2.35156266
12MP0003077_abnormal_cell_cycle2.20555861
13MP0003718_maternal_effect2.15069569
14* MP0001929_abnormal_gametogenesis2.14952892
15MP0003698_abnormal_male_reproductive2.07606128
16* MP0002210_abnormal_sex_determination2.04483034
17MP0006292_abnormal_olfactory_placode2.02648673
18MP0003786_premature_aging1.99877423
19MP0010352_gastrointestinal_tract_polyps1.97618668
20MP0001293_anophthalmia1.96775849
21MP0008995_early_reproductive_senescence1.83050220
22MP0003890_abnormal_embryonic-extraembry1.75838970
23MP0008007_abnormal_cellular_replicative1.69878354
24MP0003937_abnormal_limbs/digits/tail_de1.68694740
25* MP0001145_abnormal_male_reproductive1.67133510
26MP0003646_muscle_fatigue1.64316760
27MP0003011_delayed_dark_adaptation1.64078800
28* MP0000653_abnormal_sex_gland1.55335982
29MP0002938_white_spotting1.54276903
30MP0001299_abnormal_eye_distance/1.48527396
31MP0010307_abnormal_tumor_latency1.44288499
32MP0004957_abnormal_blastocyst_morpholog1.40441365
33MP0003123_paternal_imprinting1.39515762
34MP0006072_abnormal_retinal_apoptosis1.37719345
35MP0001188_hyperpigmentation1.35307328
36MP0010030_abnormal_orbit_morphology1.34932452
37MP0008932_abnormal_embryonic_tissue1.33166965
38* MP0005253_abnormal_eye_physiology1.32100106
39MP0005171_absent_coat_pigmentation1.30067554
40MP0002084_abnormal_developmental_patter1.27155747
41MP0001485_abnormal_pinna_reflex1.26476238
42MP0002102_abnormal_ear_morphology1.26449784
43MP0003935_abnormal_craniofacial_develop1.26160022
44MP0002085_abnormal_embryonic_tissue1.23785281
45MP0003119_abnormal_digestive_system1.23332746
46* MP0005551_abnormal_eye_electrophysiolog1.23137556
47MP0003941_abnormal_skin_development1.22118858
48MP0000432_abnormal_head_morphology1.21834457
49MP0000049_abnormal_middle_ear1.21746251
50MP0000350_abnormal_cell_proliferation1.21399836
51* MP0005391_vision/eye_phenotype1.20678936
52MP0005395_other_phenotype1.18743228
53MP0000778_abnormal_nervous_system1.18613325
54MP0003136_yellow_coat_color1.18342709
55MP0002161_abnormal_fertility/fecundity1.18079077
56MP0002653_abnormal_ependyma_morphology1.16339148
57MP0000631_abnormal_neuroendocrine_gland1.15618919
58MP0002009_preneoplasia1.15548021
59MP0003755_abnormal_palate_morphology1.14903721
60MP0002822_catalepsy1.13920035
61MP0002160_abnormal_reproductive_system1.12984582
62MP0001672_abnormal_embryogenesis/_devel1.12519806
63MP0005380_embryogenesis_phenotype1.12519806
64MP0001286_abnormal_eye_development1.10648100
65MP0005670_abnormal_white_adipose1.10533800
66MP0000428_abnormal_craniofacial_morphol1.09150358
67MP0004197_abnormal_fetal_growth/weight/1.08642301
68MP0003861_abnormal_nervous_system1.07285510
69MP0001119_abnormal_female_reproductive1.06229350
70MP0005076_abnormal_cell_differentiation1.05820102
71MP0002249_abnormal_larynx_morphology1.05072469
72MP0002233_abnormal_nose_morphology1.04646543
73MP0002697_abnormal_eye_size1.03242824
74MP0008789_abnormal_olfactory_epithelium1.02810298
75MP0009703_decreased_birth_body1.02643243
76MP0005248_abnormal_Harderian_gland1.02230792
77MP0000955_abnormal_spinal_cord1.01711372
78MP0001324_abnormal_eye_pigmentation1.01560950
79MP0001486_abnormal_startle_reflex0.99139635
80MP0002092_abnormal_eye_morphology0.99110646
81MP0003943_abnormal_hepatobiliary_system0.98985331
82MP0003385_abnormal_body_wall0.98710907
83MP0005377_hearing/vestibular/ear_phenot0.98560310
84MP0003878_abnormal_ear_physiology0.98560310
85MP0002116_abnormal_craniofacial_bone0.97557272
86MP0010678_abnormal_skin_adnexa0.95587775
87MP0001697_abnormal_embryo_size0.95491164
88MP0005646_abnormal_pituitary_gland0.94535458
89MP0003984_embryonic_growth_retardation0.93655033
90MP0000534_abnormal_ureter_morphology0.92282661
91MP0002088_abnormal_embryonic_growth/wei0.90236384
92MP0001730_embryonic_growth_arrest0.88575541
93MP0005389_reproductive_system_phenotype0.88390789
94MP0005187_abnormal_penis_morphology0.88284333
95MP0002109_abnormal_limb_morphology0.88112193
96MP0003868_abnormal_feces_composition0.87558070
97MP0009697_abnormal_copulation0.87479312
98MP0009672_abnormal_birth_weight0.87404244
99MP0002095_abnormal_skin_pigmentation0.87269148
100MP0002086_abnormal_extraembryonic_tissu0.86763398
101MP0003699_abnormal_female_reproductive0.86578433
102MP0003950_abnormal_plasma_membrane0.86324151
103MP0003115_abnormal_respiratory_system0.85988169
104MP0002396_abnormal_hematopoietic_system0.85665296
105MP0000015_abnormal_ear_pigmentation0.85664563
106MP0000383_abnormal_hair_follicle0.85095604
107MP0005499_abnormal_olfactory_system0.84522242
108MP0005394_taste/olfaction_phenotype0.84522242
109MP0004808_abnormal_hematopoietic_stem0.84300137
110MP0001984_abnormal_olfaction0.83258096
111MP0002081_perinatal_lethality0.83136807
112MP0001879_abnormal_lymphatic_vessel0.82755477
113MP0001346_abnormal_lacrimal_gland0.82201049
114MP0000537_abnormal_urethra_morphology0.81934586
115MP0002152_abnormal_brain_morphology0.81358586
116MP0003942_abnormal_urinary_system0.80765026
117MP0005623_abnormal_meninges_morphology0.79095832
118MP0000427_abnormal_hair_cycle0.78791909
119MP0002075_abnormal_coat/hair_pigmentati0.77792217
120MP0002184_abnormal_innervation0.77625622
121MP0004233_abnormal_muscle_weight0.77137244
122MP0003938_abnormal_ear_development0.76796506
123MP0000313_abnormal_cell_death0.76571846
124MP0002234_abnormal_pharynx_morphology0.75874078
125MP0002080_prenatal_lethality0.75409474
126MP0002114_abnormal_axial_skeleton0.75373785
127MP0003122_maternal_imprinting0.74292648
128MP0005174_abnormal_tail_pigmentation0.72731991
129MP0002108_abnormal_muscle_morphology0.70709155
130MP0003632_abnormal_nervous_system0.70277576
131MP0005645_abnormal_hypothalamus_physiol0.67925531
132MP0000733_abnormal_muscle_development0.67768390

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.99523987
2Absent/shortened dynein arms (HP:0200106)4.28830832
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.28830832
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99044417
5Chromsome breakage (HP:0040012)3.98125832
6Abnormal respiratory motile cilium physiology (HP:0012261)3.52274093
7Volvulus (HP:0002580)3.23081880
8Abnormal respiratory motile cilium morphology (HP:0005938)3.15431827
9Abnormal respiratory epithelium morphology (HP:0012253)3.15431827
10Abnormal ciliary motility (HP:0012262)3.09875942
11Ectopic kidney (HP:0000086)3.04367323
12Impulsivity (HP:0100710)2.85747756
13Hyperkalemia (HP:0002153)2.85005358
14Abnormality of chromosome stability (HP:0003220)2.74469473
15Abnormality of the fingertips (HP:0001211)2.64778743
16Nephronophthisis (HP:0000090)2.64413304
17Nephroblastoma (Wilms tumor) (HP:0002667)2.61950633
18Rhinitis (HP:0012384)2.61623370
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.54533516
20Meckel diverticulum (HP:0002245)2.51109528
21Genetic anticipation (HP:0003743)2.47444341
22Supernumerary spleens (HP:0009799)2.44011339
23Embryonal renal neoplasm (HP:0011794)2.43766018
24Short 4th metacarpal (HP:0010044)2.43618546
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43618546
26Medulloblastoma (HP:0002885)2.41632484
27Bell-shaped thorax (HP:0001591)2.40925578
28Sandal gap (HP:0001852)2.40444469
29Abnormality of the ileum (HP:0001549)2.39265433
30Abnormality of the nasal septum (HP:0000419)2.32630530
31Median cleft lip (HP:0000161)2.30753281
32Abnormality of the labia minora (HP:0012880)2.30038761
33Midline defect of the nose (HP:0004122)2.27208719
34Abnormality of the renal medulla (HP:0100957)2.27113630
35Hepatoblastoma (HP:0002884)2.25791019
36Abnormality of the preputium (HP:0100587)2.21798772
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.16542677
38Chronic bronchitis (HP:0004469)2.15424692
39Abnormality of the carotid arteries (HP:0005344)2.14729036
40Papillary thyroid carcinoma (HP:0002895)2.13110359
41Abnormality of the ischium (HP:0003174)2.12948169
42Duodenal stenosis (HP:0100867)2.10503118
43Small intestinal stenosis (HP:0012848)2.10503118
44Acute myeloid leukemia (HP:0004808)2.10397949
45Progressive cerebellar ataxia (HP:0002073)2.09478502
46Postaxial foot polydactyly (HP:0001830)2.09272749
47Neoplasm of the oral cavity (HP:0100649)2.08532177
48Pancreatic fibrosis (HP:0100732)2.08379734
49Facial cleft (HP:0002006)2.07036478
50Neoplasm of striated muscle (HP:0009728)2.05609198
51Long eyelashes (HP:0000527)2.05483822
52True hermaphroditism (HP:0010459)2.04943528
53Increased nuchal translucency (HP:0010880)2.03739630
54Cutaneous finger syndactyly (HP:0010554)2.02970338
55Abnormal lung lobation (HP:0002101)2.02938028
56Bronchiectasis (HP:0002110)2.02174105
57Sloping forehead (HP:0000340)2.00700899
58Rhabdomyosarcoma (HP:0002859)2.00194067
59Preaxial hand polydactyly (HP:0001177)1.97833730
60Selective tooth agenesis (HP:0001592)1.97377875
61Male infertility (HP:0003251)1.96648800
62Infertility (HP:0000789)1.96416170
63Molar tooth sign on MRI (HP:0002419)1.94858752
64Abnormality of midbrain morphology (HP:0002418)1.94858752
65Aplasia/Hypoplasia of the earlobes (HP:0009906)1.94572738
66* Obsessive-compulsive behavior (HP:0000722)1.93602353
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.91539520
68Clubbing of toes (HP:0100760)1.90436249
69Trigonocephaly (HP:0000243)1.89869510
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88905344
71Abnormality of the parathyroid morphology (HP:0011766)1.88252679
72Aqueductal stenosis (HP:0002410)1.87909455
73Gaze-evoked nystagmus (HP:0000640)1.85586715
74Protruding tongue (HP:0010808)1.85288962
75Oligodactyly (hands) (HP:0001180)1.84310930
76Absent frontal sinuses (HP:0002688)1.84292747
77Duplicated collecting system (HP:0000081)1.84006934
78Hypoplastic labia majora (HP:0000059)1.83306705
79Glioma (HP:0009733)1.82601215
80Narrow palate (HP:0000189)1.82145385
81Fibular hypoplasia (HP:0003038)1.81268714
82Anal stenosis (HP:0002025)1.80223628
83Thyroid carcinoma (HP:0002890)1.79945524
84Intellectual disability, moderate (HP:0002342)1.78846088
85Abnormality of the astrocytes (HP:0100707)1.78740102
86Astrocytoma (HP:0009592)1.78740102
87Abnormal hair whorl (HP:0010721)1.78650169
88Partial agenesis of the corpus callosum (HP:0001338)1.77628151
89Microglossia (HP:0000171)1.77322757
90Abnormality of the renal collecting system (HP:0004742)1.75995924
91High anterior hairline (HP:0009890)1.74861110
92Prominent nose (HP:0000448)1.74388716
93Hypoplastic ischia (HP:0003175)1.73762705
94Abnormality of the incisor (HP:0000676)1.73303077
95Attenuation of retinal blood vessels (HP:0007843)1.72109101
96Cutaneous syndactyly (HP:0012725)1.71991851
97Abnormality of the columella (HP:0009929)1.71937502
98Abnormality of the duodenum (HP:0002246)1.71902070
99* Truncal obesity (HP:0001956)1.70920810
100Medial flaring of the eyebrow (HP:0010747)1.70731125
101Abnormal spermatogenesis (HP:0008669)1.70370620
102Abnormality of the labia majora (HP:0012881)1.69344567
103Abnormal number of incisors (HP:0011064)1.68877958
104Bifid tongue (HP:0010297)1.68428677
105Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68234482
106Deep philtrum (HP:0002002)1.68217496
107Congenital stationary night blindness (HP:0007642)1.68142522
108Abnormality of chromosome segregation (HP:0002916)1.67865069
109Supernumerary ribs (HP:0005815)1.67660609
110Abnormality of the phalanges of the hallux (HP:0010057)1.67256428
111Intestinal atresia (HP:0011100)1.67049959
112Short ribs (HP:0000773)1.66999210
113Abnormality of permanent molar morphology (HP:0011071)1.66540325
114Abnormality of the dental root (HP:0006486)1.66540325
115Taurodontia (HP:0000679)1.66540325
116Abnormality of DNA repair (HP:0003254)1.66485809
117Ependymoma (HP:0002888)1.66404250
118Skull defect (HP:0001362)1.66093047
119Absent radius (HP:0003974)1.65612027
120Abnormality of abdominal situs (HP:0011620)1.65125502
121Abdominal situs inversus (HP:0003363)1.65125502
122Esophageal atresia (HP:0002032)1.64951982
123Patellar aplasia (HP:0006443)1.64930867
124Lip pit (HP:0100267)1.64788892
125Omphalocele (HP:0001539)1.64715643
126Hyperventilation (HP:0002883)1.63793325
127Bony spicule pigmentary retinopathy (HP:0007737)1.63592046
128Abnormality of the parietal bone (HP:0002696)1.63211554
129Cystic liver disease (HP:0006706)1.62573723
130Abnormality of molar morphology (HP:0011070)1.62170611
131Abnormality of molar (HP:0011077)1.62170611
132Severe visual impairment (HP:0001141)1.61780459
133Shawl scrotum (HP:0000049)1.61727906
134Hypopigmentation of the fundus (HP:0007894)1.61701745
135Embryonal neoplasm (HP:0002898)1.61670193
136Heterotopia (HP:0002282)1.60378002
137Scotoma (HP:0000575)1.60186769
138Neoplasm of the heart (HP:0100544)1.59969676
139Pancreatic cysts (HP:0001737)1.59822721
140Astigmatism (HP:0000483)1.59770658
141Oligodactyly (HP:0012165)1.59283209
14211 pairs of ribs (HP:0000878)1.58988923
143Anophthalmia (HP:0000528)1.58733724
144Poor coordination (HP:0002370)1.58292017
145Abnormality of the epiphyses of the hand (HP:0005924)1.57304386
146Underdeveloped nasal alae (HP:0000430)1.56467407
147Tubular atrophy (HP:0000092)1.55219517
148Osteomalacia (HP:0002749)1.55141352
149Abnormality of the pubic bones (HP:0003172)1.55087248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.31481911
2CDC74.24507285
3BRD42.99196852
4SRPK12.84711264
5NEK22.70049167
6ZAK2.52250808
7TTK2.49281893
8PLK42.47408596
9LATS12.39423919
10CHEK22.18595362
11ATR2.09439385
12MKNK22.08658741
13TLK11.78541383
14NUAK11.77819566
15PDK31.77191433
16PDK41.77191433
17MKNK11.76862037
18MAP3K101.76566973
19WEE11.75132838
20PNCK1.70748155
21PLK31.59926641
22ATM1.59232711
23PLK11.53659727
24STK31.51492440
25CHEK11.47610202
26MELK1.44275213
27VRK11.42536272
28PASK1.38168608
29CAMK1D1.37521772
30YES11.28776435
31CAMK1G1.27296143
32CDK71.23771675
33ERBB31.21766605
34CDK91.20046247
35AURKB1.17265466
36AKT31.16800696
37PDK21.15714202
38INSRR1.14549412
39STK38L1.14431536
40CDK31.13309742
41PRKD31.12228451
42STK41.11744782
43SGK21.05271159
44MAPK151.05222937
45NLK1.04462106
46ICK1.02548659
47BRSK21.00158111
48CDK10.95564200
49TYRO30.95207343
50CDK20.94173873
51MET0.91862244
52CCNB10.90173434
53STK390.89600689
54DYRK30.89386436
55CDK40.88537440
56EIF2AK20.87782856
57ACVR1B0.84626861
58CDK60.84054868
59PBK0.82771106
60NEK60.81194818
61WNK10.79055143
62CAMK40.78764160
63MTOR0.78230570
64WNK30.77248411
65TAF10.76659551
66RPS6KA50.75611710
67CSNK1D0.74242722
68CASK0.72460331
69MAPK130.70569519
70RPS6KB10.70411270
71TNIK0.70218806
72MARK20.69314708
73MAPK140.68253387
74PLK20.68250011
75PKN20.67987898
76PRKDC0.67986321
77CDK80.67030455
78CSNK1A1L0.65152499
79RPS6KB20.64618508
80NTRK30.63905389
81PIM10.63781525
82GSK3B0.63558865
83NTRK20.61136730
84MAP3K20.57654344
85BMPR1B0.56851526
86EEF2K0.56826959
87SGK30.56505078
88PDGFRB0.55368482
89PIK3CG0.54396418
90MAP3K70.53801479
91FGFR20.51280942
92BCR0.51269839
93PRKAA20.50478217
94FRK0.48867427
95PDGFRA0.48815537
96BRSK10.48394453
97GRK10.47595531
98AKT10.46755994
99RET0.45995578
100MST1R0.44226604
101CHUK0.44056521
102FGFR30.43944484
103SGK10.41894147
104SGK4940.41884898
105SGK2230.41884898
106MAP4K20.41422228
107CLK10.41019463
108FGFR10.40421854
109MAPK10.39892931
110RPS6KA40.39167762
111CSNK1G10.38866190
112MAPK100.38830498
113CSNK1E0.38746920
114DYRK1A0.38207671
115PRKAA10.37968201
116NEK90.37838694
117TSSK60.37157037
118MAPK80.37156331
119STK110.36825875
120RPS6KA30.34849207
121EPHA20.34538286
122AURKA0.33559589
123MAP3K40.33546755
124PTK60.33226598
125STK380.32824080
126AKT20.32804947
127MAP2K70.32782195
128CSNK2A20.29508904
129ERBB20.29068856

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.96613724
2Mismatch repair_Homo sapiens_hsa034303.11384245
3Homologous recombination_Homo sapiens_hsa034402.99508221
4DNA replication_Homo sapiens_hsa030302.92504694
5Cell cycle_Homo sapiens_hsa041102.81294304
6Non-homologous end-joining_Homo sapiens_hsa034502.77347907
7Systemic lupus erythematosus_Homo sapiens_hsa053222.57177171
8Basal transcription factors_Homo sapiens_hsa030222.43809901
9mRNA surveillance pathway_Homo sapiens_hsa030152.20397176
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19741074
11Base excision repair_Homo sapiens_hsa034102.16928449
12RNA transport_Homo sapiens_hsa030132.15139910
13Spliceosome_Homo sapiens_hsa030402.08852268
14Nucleotide excision repair_Homo sapiens_hsa034202.07213720
15Phototransduction_Homo sapiens_hsa047442.05045069
16RNA degradation_Homo sapiens_hsa030181.94695647
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64463021
18Alcoholism_Homo sapiens_hsa050341.62367334
19Basal cell carcinoma_Homo sapiens_hsa052171.54590561
20One carbon pool by folate_Homo sapiens_hsa006701.39032440
21Thyroid cancer_Homo sapiens_hsa052161.37101166
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32154248
23Oocyte meiosis_Homo sapiens_hsa041141.31677024
24p53 signaling pathway_Homo sapiens_hsa041151.30077892
25Lysine degradation_Homo sapiens_hsa003101.29340764
26MicroRNAs in cancer_Homo sapiens_hsa052061.26300448
27Viral carcinogenesis_Homo sapiens_hsa052031.24963137
28Type II diabetes mellitus_Homo sapiens_hsa049301.20230680
29RNA polymerase_Homo sapiens_hsa030201.19341230
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17659555
31Hedgehog signaling pathway_Homo sapiens_hsa043401.17159003
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12139667
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12032476
34Wnt signaling pathway_Homo sapiens_hsa043101.06807636
35Dorso-ventral axis formation_Homo sapiens_hsa043201.02718096
36Prostate cancer_Homo sapiens_hsa052151.01312634
37Glioma_Homo sapiens_hsa052141.01262922
38TGF-beta signaling pathway_Homo sapiens_hsa043500.99799675
39Fatty acid biosynthesis_Homo sapiens_hsa000610.99717676
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98592780
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98068747
42ABC transporters_Homo sapiens_hsa020100.98052020
43Pyrimidine metabolism_Homo sapiens_hsa002400.97465445
44Purine metabolism_Homo sapiens_hsa002300.97327037
45Hippo signaling pathway_Homo sapiens_hsa043900.96828805
46Herpes simplex infection_Homo sapiens_hsa051680.96115609
47Notch signaling pathway_Homo sapiens_hsa043300.94793531
48Adherens junction_Homo sapiens_hsa045200.94414141
49HTLV-I infection_Homo sapiens_hsa051660.92500952
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80874010
51Small cell lung cancer_Homo sapiens_hsa052220.76595190
52Long-term depression_Homo sapiens_hsa047300.76006498
53Cholinergic synapse_Homo sapiens_hsa047250.75863290
54Prolactin signaling pathway_Homo sapiens_hsa049170.75734457
55Gap junction_Homo sapiens_hsa045400.75257704
56Colorectal cancer_Homo sapiens_hsa052100.73108622
57Endometrial cancer_Homo sapiens_hsa052130.72919913
58Renal cell carcinoma_Homo sapiens_hsa052110.70901305
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69284796
60Circadian entrainment_Homo sapiens_hsa047130.68634522
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.67261938
62Inositol phosphate metabolism_Homo sapiens_hsa005620.67130452
63Epstein-Barr virus infection_Homo sapiens_hsa051690.66040411
64Pathways in cancer_Homo sapiens_hsa052000.65035130
65Nicotine addiction_Homo sapiens_hsa050330.64078996
66Circadian rhythm_Homo sapiens_hsa047100.63928638
67FoxO signaling pathway_Homo sapiens_hsa040680.62205674
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61575011
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61252717
70Focal adhesion_Homo sapiens_hsa045100.60924407
71Selenocompound metabolism_Homo sapiens_hsa004500.59545497
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58474849
73Melanoma_Homo sapiens_hsa052180.58110480
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57773392
75Calcium signaling pathway_Homo sapiens_hsa040200.57227275
76Ovarian steroidogenesis_Homo sapiens_hsa049130.56083697
77Serotonergic synapse_Homo sapiens_hsa047260.54290347
78mTOR signaling pathway_Homo sapiens_hsa041500.53181277
79Taste transduction_Homo sapiens_hsa047420.52665911
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.51663054
81Pancreatic secretion_Homo sapiens_hsa049720.51557148
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51222016
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50920383
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.50576627
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49674884
86Protein digestion and absorption_Homo sapiens_hsa049740.49493196
87Insulin signaling pathway_Homo sapiens_hsa049100.48218857
88Acute myeloid leukemia_Homo sapiens_hsa052210.47647898
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46226842
90Thyroid hormone synthesis_Homo sapiens_hsa049180.45457630
91Salivary secretion_Homo sapiens_hsa049700.44830053
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.44429900
93Mineral absorption_Homo sapiens_hsa049780.43900033
94Glucagon signaling pathway_Homo sapiens_hsa049220.42291263
95Melanogenesis_Homo sapiens_hsa049160.40957387
96Non-small cell lung cancer_Homo sapiens_hsa052230.40053176
97Axon guidance_Homo sapiens_hsa043600.39832962
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39391496
99Tight junction_Homo sapiens_hsa045300.39334854
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37378715
101Measles_Homo sapiens_hsa051620.37098929
102Ether lipid metabolism_Homo sapiens_hsa005650.36768471
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35976469
104Hepatitis B_Homo sapiens_hsa051610.35734404
105Chronic myeloid leukemia_Homo sapiens_hsa052200.34608656
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34337300
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33618943
108ECM-receptor interaction_Homo sapiens_hsa045120.32390766
109Choline metabolism in cancer_Homo sapiens_hsa052310.31232900
110Proteoglycans in cancer_Homo sapiens_hsa052050.30781946
111Antigen processing and presentation_Homo sapiens_hsa046120.30737821
112Morphine addiction_Homo sapiens_hsa050320.30683554
113Glutamatergic synapse_Homo sapiens_hsa047240.30257950
114Autoimmune thyroid disease_Homo sapiens_hsa053200.30124767
115Influenza A_Homo sapiens_hsa051640.30084800
116Sphingolipid metabolism_Homo sapiens_hsa006000.29993732
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29853708
118cAMP signaling pathway_Homo sapiens_hsa040240.29292690
119Hematopoietic cell lineage_Homo sapiens_hsa046400.28224031
120Olfactory transduction_Homo sapiens_hsa047400.28114278
121MAPK signaling pathway_Homo sapiens_hsa040100.27291846
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.27136077
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26935963
124Estrogen signaling pathway_Homo sapiens_hsa049150.25139887
125Pancreatic cancer_Homo sapiens_hsa052120.25074214
126Long-term potentiation_Homo sapiens_hsa047200.24955349
127ErbB signaling pathway_Homo sapiens_hsa040120.22428284

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