ALOX12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.78859851
2neutrophil activation involved in immune response (GO:0002283)7.61970005
3protein neddylation (GO:0045116)5.78257767
4platelet aggregation (GO:0070527)5.65953365
5leukocyte migration involved in inflammatory response (GO:0002523)5.34245421
6blood coagulation, intrinsic pathway (GO:0007597)5.28195506
7regulation of integrin-mediated signaling pathway (GO:2001044)4.94690489
8neutrophil activation (GO:0042119)4.82796212
9* regulation of platelet activation (GO:0010543)4.74237161
10negative regulation of thymocyte apoptotic process (GO:0070244)4.65507472
11adenosine receptor signaling pathway (GO:0001973)4.64410328
12regulation of integrin activation (GO:0033623)4.63779213
13positive regulation of mast cell activation (GO:0033005)4.60895723
14keratinocyte development (GO:0003334)4.49998262
15negative regulation of norepinephrine secretion (GO:0010700)4.41464176
16megakaryocyte development (GO:0035855)4.32400943
17angiogenesis involved in wound healing (GO:0060055)4.31201577
18granulocyte activation (GO:0036230)4.29871566
19homotypic cell-cell adhesion (GO:0034109)4.11073529
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.08098126
21sphingoid metabolic process (GO:0046519)4.03254346
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.93497460
23platelet degranulation (GO:0002576)3.90624242
24negative regulation of heart rate (GO:0010459)3.84112041
25* regulation of platelet aggregation (GO:0090330)3.82822238
26positive regulation of macrophage differentiation (GO:0045651)3.76364271
27mesenchymal cell differentiation involved in renal system development (GO:2001012)3.73691405
28mesenchymal cell differentiation involved in kidney development (GO:0072161)3.73691405
29platelet activation (GO:0030168)3.70469614
30keratinization (GO:0031424)3.69086512
31negative regulation of keratinocyte proliferation (GO:0010839)3.64570471
32regulation of MHC class II biosynthetic process (GO:0045346)3.62427655
33amino sugar catabolic process (GO:0046348)3.60193132
34regulation of mast cell degranulation (GO:0043304)3.59063102
35negative regulation of interleukin-17 production (GO:0032700)3.58827474
36regulation of interleukin-8 secretion (GO:2000482)3.55848211
37positive regulation of systemic arterial blood pressure (GO:0003084)3.53366295
38platelet formation (GO:0030220)3.49785197
39positive regulation of cAMP-mediated signaling (GO:0043950)3.49745072
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49252454
41sphingosine metabolic process (GO:0006670)3.48969525
42regulation of mast cell activation (GO:0033003)3.47202385
43regulation of Golgi to plasma membrane protein transport (GO:0042996)3.45909412
44positive regulation of interleukin-8 secretion (GO:2000484)3.44335653
45polyamine biosynthetic process (GO:0006596)3.44226062
46purinergic receptor signaling pathway (GO:0035587)3.43834024
47regulation of timing of cell differentiation (GO:0048505)3.42519265
48glucosamine-containing compound catabolic process (GO:1901072)3.42279968
49regulation of mast cell activation involved in immune response (GO:0033006)3.41517486
50negative regulation of T cell apoptotic process (GO:0070233)3.38851178
51leukocyte degranulation (GO:0043299)3.37002447
52positive regulation of blood coagulation (GO:0030194)3.35587175
53positive regulation of hemostasis (GO:1900048)3.35587175
54diol metabolic process (GO:0034311)3.32035445
55desmosome organization (GO:0002934)3.30309452
56low-density lipoprotein particle remodeling (GO:0034374)3.29749397
57G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.25084494
58positive regulation of B cell differentiation (GO:0045579)3.22703945
59positive regulation of granulocyte differentiation (GO:0030854)3.22472188
60energy homeostasis (GO:0097009)3.20424479
61negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.20409476
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17860630
63negative regulation of T-helper cell differentiation (GO:0045623)3.17860630
64myeloid cell activation involved in immune response (GO:0002275)3.14917738
65fusion of sperm to egg plasma membrane (GO:0007342)3.14766652
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11141741
67negative regulation of stress fiber assembly (GO:0051497)3.11068603
68positive regulation of Rho protein signal transduction (GO:0035025)3.10567290
69positive regulation of mast cell activation involved in immune response (GO:0033008)3.08953466
70positive regulation of mast cell degranulation (GO:0043306)3.08953466
71negative regulation of response to food (GO:0032096)3.08649772
72negative regulation of appetite (GO:0032099)3.08649772
73limb bud formation (GO:0060174)3.07816758
74otic vesicle formation (GO:0030916)3.07793597
75DNA integration (GO:0015074)3.06769996
76G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06038218
77negative regulation of bone mineralization (GO:0030502)3.05941418
78regulation of macrophage derived foam cell differentiation (GO:0010743)3.05322351
79sulfate transport (GO:0008272)3.04963432
80positive regulation of receptor recycling (GO:0001921)3.04960506
81female gonad development (GO:0008585)3.04413307
82GPI anchor biosynthetic process (GO:0006506)3.04206476
83negative regulation of protein localization to cell surface (GO:2000009)3.01539522
84one-carbon compound transport (GO:0019755)3.00305911
85positive regulation of coagulation (GO:0050820)2.98754273
86regulation of development, heterochronic (GO:0040034)2.98529010
87myeloid cell development (GO:0061515)2.97639495
88dendritic cell chemotaxis (GO:0002407)2.97531046
89phagocytosis, engulfment (GO:0006911)2.95757657
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94476571
91negative regulation of neural precursor cell proliferation (GO:2000178)2.94374461
92termination of G-protein coupled receptor signaling pathway (GO:0038032)2.93992731
93regulation of lipoprotein metabolic process (GO:0050746)2.93935976
94mitochondrial calcium ion transport (GO:0006851)2.93867119
95ceramide catabolic process (GO:0046514)2.93704365
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93395984
97regulation of interleukin-17 production (GO:0032660)2.93276455
98regulation of norepinephrine secretion (GO:0014061)2.93085036
99autophagic vacuole fusion (GO:0000046)2.92120065
100preassembly of GPI anchor in ER membrane (GO:0016254)2.91770862
101negative regulation of myoblast differentiation (GO:0045662)2.90941059
102extracellular fibril organization (GO:0043206)2.89302943
103facial nerve structural organization (GO:0021612)2.88745871
104termination of signal transduction (GO:0023021)2.88046169
105regulation of inositol phosphate biosynthetic process (GO:0010919)2.88007703
106negative regulation of mast cell activation (GO:0033004)2.87243286
107regulation of female receptivity (GO:0045924)2.86026718
108regulation of leukocyte degranulation (GO:0043300)2.85790592
109negative regulation of erythrocyte differentiation (GO:0045647)2.85779992
110positive regulation of gamma-delta T cell activation (GO:0046645)2.84551607
111negative regulation of calcium ion transport into cytosol (GO:0010523)2.82811435
112peptide cross-linking (GO:0018149)2.79573710
113negative regulation of execution phase of apoptosis (GO:1900118)2.78890471
114Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78668616
115regulation of cell proliferation involved in kidney development (GO:1901722)2.76946831
116detection of other organism (GO:0098543)2.76353120
117mesonephros development (GO:0001823)2.75050763
118membrane invagination (GO:0010324)2.74653694
119negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.74013275
120regulation of regulatory T cell differentiation (GO:0045589)2.73635704
121pyrimidine nucleoside catabolic process (GO:0046135)2.73507755
122* lipoxygenase pathway (GO:0019372)2.72215836
123daunorubicin metabolic process (GO:0044597)2.71603319
124polyketide metabolic process (GO:0030638)2.71603319
125doxorubicin metabolic process (GO:0044598)2.71603319
126adenosine metabolic process (GO:0046085)2.71485283
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.71410249
128cornea development in camera-type eye (GO:0061303)2.70967973
129negative regulation of heart contraction (GO:0045822)2.70848870
130regulation of receptor recycling (GO:0001919)2.70717511
131lymph vessel development (GO:0001945)2.70371553
132monoamine transport (GO:0015844)2.70332406
133regulation of cholesterol efflux (GO:0010874)2.70257908
134extracellular regulation of signal transduction (GO:1900115)2.69382404
135extracellular negative regulation of signal transduction (GO:1900116)2.69382404
136detection of bacterium (GO:0016045)2.68271673
137GPI anchor metabolic process (GO:0006505)2.67672732
138pharyngeal system development (GO:0060037)2.66515514
139sulfate transmembrane transport (GO:1902358)2.66384594
140fibril organization (GO:0097435)2.64902137
141cell differentiation involved in metanephros development (GO:0072202)2.64216891
142replicative senescence (GO:0090399)2.63739898
143kinetochore assembly (GO:0051382)2.62830650
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.61469171
145positive regulation of B cell mediated immunity (GO:0002714)2.61148781
146cell proliferation in forebrain (GO:0021846)2.60902110
147polyol transport (GO:0015791)2.58502637
148cerebral cortex radially oriented cell migration (GO:0021799)2.57051687
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.54595375
150* superoxide anion generation (GO:0042554)2.50429765
151regulation of keratinocyte proliferation (GO:0010837)2.50197374
152positive regulation of cellular amide metabolic process (GO:0034250)2.48680079
153cyclooxygenase pathway (GO:0019371)2.45771715
154endothelium development (GO:0003158)2.44653675
155centriole assembly (GO:0098534)2.43585793
156protein heterotetramerization (GO:0051290)2.42987348
157detection of molecule of bacterial origin (GO:0032490)2.42550679
158cranial nerve structural organization (GO:0021604)2.41906223
159microtubule depolymerization (GO:0007019)2.41077499
160poly(A)+ mRNA export from nucleus (GO:0016973)2.40349245
161ganglion development (GO:0061548)2.40179071
162rRNA modification (GO:0000154)2.40145583
163oligosaccharide catabolic process (GO:0009313)2.39910878
164sympathetic nervous system development (GO:0048485)2.39252789
165purinergic nucleotide receptor signaling pathway (GO:0035590)2.37323399
166chemical homeostasis within a tissue (GO:0048875)2.37093663
167cellular response to gamma radiation (GO:0071480)2.35410081
168sphingolipid catabolic process (GO:0030149)2.34040503
169positive regulation of uterine smooth muscle contraction (GO:0070474)2.30656514
170negative regulation of systemic arterial blood pressure (GO:0003085)2.30512647
171regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27576780
172microglial cell activation (GO:0001774)2.27499944
173negative regulation of transcription by competitive promoter binding (GO:0010944)2.26487511
174regulation of RIG-I signaling pathway (GO:0039535)2.25315626
175mitotic cell cycle arrest (GO:0071850)2.25137370
176regulation of establishment of cell polarity (GO:2000114)2.24112153
177DNA synthesis involved in DNA repair (GO:0000731)2.22660641
178rRNA methylation (GO:0031167)2.22208635
179regulation of male gonad development (GO:2000018)2.21799386
180positive regulation of interleukin-1 beta secretion (GO:0050718)2.20550073
181regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.20509518
182response to peptidoglycan (GO:0032494)2.16535963
183mesenchymal cell differentiation (GO:0048762)2.15834996
184termination of RNA polymerase I transcription (GO:0006363)2.15092336
185pyrimidine dimer repair (GO:0006290)2.14520089
186lymphangiogenesis (GO:0001946)2.13095958
187nucleoside diphosphate catabolic process (GO:0009134)2.12570138
188androgen biosynthetic process (GO:0006702)2.10287442
189termination of RNA polymerase III transcription (GO:0006386)2.09298853
190transcription elongation from RNA polymerase III promoter (GO:0006385)2.09298853
191norepinephrine metabolic process (GO:0042415)2.07924150
192positive regulation of antigen processing and presentation (GO:0002579)2.07887261
193dendritic cell migration (GO:0036336)2.07361780
194dentate gyrus development (GO:0021542)2.07208091
195regulation of chemokine secretion (GO:0090196)2.06935185
196startle response (GO:0001964)2.06893193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.77722312
2* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.27874463
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.89469601
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74962516
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66231178
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42286507
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.34751368
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21007866
9GATA1_19941826_ChIP-Seq_K562_Human3.18955852
10GBX2_23144817_ChIP-Seq_PC3_Human3.09519344
11* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.06535397
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88630069
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.88559151
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76803954
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72971181
16GATA1_19941827_ChIP-Seq_MEL_Mouse2.72360590
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71393852
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.70880508
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69870791
20GATA2_19941826_ChIP-Seq_K562_Human2.64205311
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60900754
22SPI1_23127762_ChIP-Seq_K562_Human2.57746354
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.55270452
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51427371
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.48925890
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.37059754
27SUZ12_27294783_Chip-Seq_NPCs_Mouse2.34396795
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.29668557
29RUNX_20019798_ChIP-Seq_JUKART_Human2.24505761
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.20967579
31NFE2_27457419_Chip-Seq_LIVER_Mouse2.20885560
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.16667794
33SMAD_19615063_ChIP-ChIP_OVARY_Human2.16158164
34GATA1_22383799_ChIP-Seq_G1ME_Mouse2.15974843
35* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13833941
36EZH2_22144423_ChIP-Seq_EOC_Human2.13221294
37IRF8_27001747_Chip-Seq_BMDM_Mouse2.11409696
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09993236
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.09638866
40PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05132123
41POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02359054
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.96891911
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95106027
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94649321
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.90255737
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89653704
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87428244
48VDR_22108803_ChIP-Seq_LS180_Human1.82519104
49TAF15_26573619_Chip-Seq_HEK293_Human1.82460200
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.82446676
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80730235
52RNF2_27304074_Chip-Seq_NSC_Mouse1.80713515
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.80111558
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.79547943
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.79428887
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.76478218
57GATA1_22025678_ChIP-Seq_K562_Human1.75581153
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73770178
59P53_22387025_ChIP-Seq_ESCs_Mouse1.72770468
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71980300
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.71476528
62NMYC_18555785_Chip-Seq_ESCs_Mouse1.67720323
63P300_19829295_ChIP-Seq_ESCs_Human1.66288004
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65311161
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.62995890
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62124880
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.61518121
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.61153039
69HTT_18923047_ChIP-ChIP_STHdh_Human1.59491602
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.58408516
71* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57880128
72KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56942845
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56613624
74FUS_26573619_Chip-Seq_HEK293_Human1.55631969
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55314735
76ZFX_18555785_Chip-Seq_ESCs_Mouse1.55158288
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54426294
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.53882385
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.53077982
80P300_18555785_Chip-Seq_ESCs_Mouse1.52787066
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52480260
82MYB_26560356_Chip-Seq_TH2_Human1.52206227
83GATA1_19941827_ChIP-Seq_MEL86_Mouse1.51738684
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50798423
85* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50745032
86KLF4_18555785_Chip-Seq_ESCs_Mouse1.47915641
87PU1_27457419_Chip-Seq_LIVER_Mouse1.47148819
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46736842
89SPI1_23547873_ChIP-Seq_NB4_Human1.44723755
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44302629
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44278914
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43653030
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43588122
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42725321
95IRF1_19129219_ChIP-ChIP_H3396_Human1.42423506
96ELK4_26923725_Chip-Seq_MESODERM_Mouse1.42092312
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.41853127
98UTX_26944678_Chip-Seq_JUKART_Human1.41845067
99* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41324322
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40633918
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40466762
102BP1_19119308_ChIP-ChIP_Hs578T_Human1.39878671
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38255331
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37965619
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37674672
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37037102
107* CRX_20693478_ChIP-Seq_RETINA_Mouse1.36715946
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36642295
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36614765
110SMAD1_18555785_Chip-Seq_ESCs_Mouse1.36583220
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35897110
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35479405
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35461057
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.34477217
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34159909
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33749367
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.33194982
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33144691
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32468108
120IGF1R_20145208_ChIP-Seq_DFB_Human1.32456690
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30424948
122GATA3_27048872_Chip-Seq_THYMUS_Human1.28340194
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28287890
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27003597
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.25019289
126VDR_24763502_ChIP-Seq_THP-1_Human1.24574052
127NCOR1_26117541_ChIP-Seq_K562_Human1.24005630
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21999518
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.21847283
130JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21360575
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21152024
132* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20705823
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19198786
134SMAD4_21799915_ChIP-Seq_A2780_Human1.18421345
135GATA3_26560356_Chip-Seq_TH2_Human1.17650483
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17035835
137* EZH2_27294783_Chip-Seq_ESCs_Mouse1.15895468
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15581562
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15540552
140ER_23166858_ChIP-Seq_MCF-7_Human1.15429409
141EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14036121
142RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14036121
143EWS_26573619_Chip-Seq_HEK293_Human1.12868427
144AR_21572438_ChIP-Seq_LNCaP_Human1.11656119
145FOXO3_23340844_ChIP-Seq_DLD1_Human1.11327352
146SPI1_20517297_ChIP-Seq_HL60_Human1.11253198
147MYB_26560356_Chip-Seq_TH1_Human1.10938803
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10515674
149ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10250113
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09696108
151CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09441930
152MAF_26560356_Chip-Seq_TH1_Human1.09435683
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09353132
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08266652
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08266652
156KDM2B_26808549_Chip-Seq_REH_Human1.06456600
157* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06398402
158TP53_18474530_ChIP-ChIP_U2OS_Human1.06319971
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05668504
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05019628
161TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04248705
162PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02931411
163* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02281509
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99414205
165* TCF7_22412390_ChIP-Seq_EML_Mouse0.95927189
166* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93860917
167PU_27001747_Chip-Seq_BMDM_Mouse0.92818193
168STAT1_20625510_ChIP-Seq_HELA_Human0.92761875
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92337165
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91245454
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91245454
172ERG_20517297_ChIP-Seq_VCAP_Human0.86885065
173SOX2_20726797_ChIP-Seq_SW620_Human0.86298430
174* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84940443
175TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84800323
176SMRT_27268052_Chip-Seq_Bcells_Human0.84776638
177RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83890153
178* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83147237
179PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83139610
180SALL4_22934838_ChIP-ChIP_CD34+_Human0.82537467
181TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82047159
182PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81818734
183GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80704599
184VDR_24787735_ChIP-Seq_THP-1_Human0.79723015
185EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79007109
186* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76696236
187NANOG_20526341_ChIP-Seq_ESCs_Human0.76054100
188CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75816162
189* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75757130
190SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75734622
191GATA4_25053715_ChIP-Seq_YYC3_Human0.75397424
192GATA3_21878914_ChIP-Seq_MCF-7_Human0.74734154
193OCT1_27270436_Chip-Seq_PROSTATE_Human0.73904076
194GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72625858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005464_abnormal_platelet_physiology8.44004851
2MP0006292_abnormal_olfactory_placode4.49816821
3MP0000566_synostosis3.93867900
4MP0003136_yellow_coat_color3.59531050
5MP0003941_abnormal_skin_development3.44387779
6MP0001188_hyperpigmentation3.20375564
7MP0004381_abnormal_hair_follicle3.10122364
8MP0003303_peritoneal_inflammation2.80148778
9MP0008260_abnormal_autophagy2.79658790
10MP0005645_abnormal_hypothalamus_physiol2.48904469
11MP0002102_abnormal_ear_morphology2.45824908
12MP0002277_abnormal_respiratory_mucosa2.41465936
13MP0005409_darkened_coat_color2.40926171
14MP0005083_abnormal_biliary_tract2.36624882
15MP0004510_myositis2.23332483
16MP0003566_abnormal_cell_adhesion2.22152377
17MP0005171_absent_coat_pigmentation2.18657174
18MP0002132_abnormal_respiratory_system2.17896464
19MP0003436_decreased_susceptibility_to2.13955337
20MP0010386_abnormal_urinary_bladder2.13386315
21MP0005646_abnormal_pituitary_gland2.03941177
22MP0003718_maternal_effect2.03750503
23MP0000343_altered_response_to1.98136596
24MP0005671_abnormal_response_to1.90985156
25MP0001851_eye_inflammation1.90774436
26MP0008004_abnormal_stomach_pH1.90551704
27MP0005000_abnormal_immune_tolerance1.89118173
28MP0001545_abnormal_hematopoietic_system1.83489020
29MP0005397_hematopoietic_system_phenotyp1.83489020
30MP0000230_abnormal_systemic_arterial1.77754366
31MP0010155_abnormal_intestine_physiology1.77165173
32MP0004947_skin_inflammation1.75545958
33MP0000015_abnormal_ear_pigmentation1.75452310
34MP0002638_abnormal_pupillary_reflex1.74954165
35MP0000383_abnormal_hair_follicle1.71403002
36MP0008995_early_reproductive_senescence1.71132468
37MP0002398_abnormal_bone_marrow1.70892425
38MP0001346_abnormal_lacrimal_gland1.70519582
39MP0003938_abnormal_ear_development1.69256987
40MP0001984_abnormal_olfaction1.62902111
41MP0008789_abnormal_olfactory_epithelium1.62802443
42MP0005167_abnormal_blood-brain_barrier1.59642697
43MP0001800_abnormal_humoral_immune1.58561214
44MP0003787_abnormal_imprinting1.58299676
45MP0000372_irregular_coat_pigmentation1.58186855
46MP0002723_abnormal_immune_serum1.57602264
47MP0004130_abnormal_muscle_cell1.56686468
48MP0002736_abnormal_nociception_after1.54003821
49MP0004742_abnormal_vestibular_system1.53827502
50MP0002419_abnormal_innate_immunity1.52718981
51MP0004084_abnormal_cardiac_muscle1.50754655
52MP0009333_abnormal_splenocyte_physiolog1.50230439
53MP0002452_abnormal_antigen_presenting1.49790652
54MP0005451_abnormal_body_composition1.48661994
55MP0001533_abnormal_skeleton_physiology1.48398409
56MP0004782_abnormal_surfactant_physiolog1.47916973
57MP0010368_abnormal_lymphatic_system1.47488610
58MP0002098_abnormal_vibrissa_morphology1.46284167
59MP0000026_abnormal_inner_ear1.45755346
60MP0009697_abnormal_copulation1.44967175
61MP0001986_abnormal_taste_sensitivity1.44307448
62MP0005058_abnormal_lysosome_morphology1.44264993
63MP0002163_abnormal_gland_morphology1.42262803
64MP0001879_abnormal_lymphatic_vessel1.42053040
65MP0005084_abnormal_gallbladder_morpholo1.41561738
66MP0005025_abnormal_response_to1.39104250
67MP0002420_abnormal_adaptive_immunity1.38923846
68MP0003724_increased_susceptibility_to1.38317206
69MP0001819_abnormal_immune_cell1.37296679
70MP0003866_abnormal_defecation1.36569718
71MP0002876_abnormal_thyroid_physiology1.35050084
72MP0003638_abnormal_response/metabolism_1.34376626
73MP0000689_abnormal_spleen_morphology1.33368330
74MP0003300_gastrointestinal_ulcer1.30304405
75MP0008058_abnormal_DNA_repair1.23906278
76MP0005387_immune_system_phenotype1.23296354
77MP0001790_abnormal_immune_system1.23296354
78MP0002429_abnormal_blood_cell1.23009418
79MP0002722_abnormal_immune_system1.22788326
80MP0001663_abnormal_digestive_system1.22263915
81MP0003656_abnormal_erythrocyte_physiolo1.21885321
82MP0005310_abnormal_salivary_gland1.20823113
83MP0002938_white_spotting1.19465102
84MP0003786_premature_aging1.19062440
85MP0005410_abnormal_fertilization1.18862890
86MP0002249_abnormal_larynx_morphology1.18479226
87MP0005499_abnormal_olfactory_system1.18478512
88MP0005394_taste/olfaction_phenotype1.18478512
89MP0000716_abnormal_immune_system1.16286022
90MP0000249_abnormal_blood_vessel1.15635755
91MP0009763_increased_sensitivity_to1.15352576
92MP0003315_abnormal_perineum_morphology1.15153362
93MP0002148_abnormal_hypersensitivity_rea1.14380955
94MP0002733_abnormal_thermal_nociception1.14373817
95MP0001845_abnormal_inflammatory_respons1.14077414
96MP0000858_altered_metastatic_potential1.12822024
97MP0005647_abnormal_sex_gland1.11351350
98MP0008872_abnormal_physiological_respon1.11150911
99MP0008775_abnormal_heart_ventricle1.10224294
100MP0000049_abnormal_middle_ear1.10131122
101MP0005379_endocrine/exocrine_gland_phen1.09341601
102MP0002009_preneoplasia1.09228099
103MP0000685_abnormal_immune_system1.09053665
104MP0004808_abnormal_hematopoietic_stem1.06852829
105MP0008874_decreased_physiological_sensi1.05606112
106MP0009278_abnormal_bone_marrow1.03985993
107MP0005174_abnormal_tail_pigmentation1.03188059
108MP0009764_decreased_sensitivity_to1.02783362
109MP0004036_abnormal_muscle_relaxation1.00897587
110MP0005367_renal/urinary_system_phenotyp1.00592336
111MP0000516_abnormal_urinary_system1.00592336
112MP0009765_abnormal_xenobiotic_induced1.00146830
113MP0010234_abnormal_vibrissa_follicle0.99355654
114MP0009785_altered_susceptibility_to0.97005154
115MP0009250_abnormal_appendicular_skeleto0.96601071
116MP0003693_abnormal_embryo_hatching0.96008906
117MP0003453_abnormal_keratinocyte_physiol0.95785763
118MP0001968_abnormal_touch/_nociception0.94584669
119MP0001963_abnormal_hearing_physiology0.93593173
120MP0003879_abnormal_hair_cell0.93226894
121MP0002177_abnormal_outer_ear0.92935046
122MP0003828_pulmonary_edema0.92493868
123MP0002998_abnormal_bone_remodeling0.92340322
124MP0000647_abnormal_sebaceous_gland0.91180080
125MP0005666_abnormal_adipose_tissue0.90912018
126MP0002405_respiratory_system_inflammati0.90859745
127MP0001765_abnormal_ion_homeostasis0.90034425
128MP0000762_abnormal_tongue_morphology0.89883053
129MP0001486_abnormal_startle_reflex0.89179576
130MP0001119_abnormal_female_reproductive0.88192603
131MP0002796_impaired_skin_barrier0.87287495
132MP0008057_abnormal_DNA_replication0.87267229
133MP0002233_abnormal_nose_morphology0.87124039
134MP0000703_abnormal_thymus_morphology0.86519400
135MP0000613_abnormal_salivary_gland0.86296750
136MP0002095_abnormal_skin_pigmentation0.86279542
137MP0008877_abnormal_DNA_methylation0.86032326
138MP0005257_abnormal_intraocular_pressure0.85626031
139MP0010329_abnormal_lipoprotein_level0.85291590
140* MP0009642_abnormal_blood_homeostasis0.84952592
141MP0000678_abnormal_parathyroid_gland0.84214494
142MP0000538_abnormal_urinary_bladder0.82203732
143MP0003075_altered_response_to0.81475220
144MP0001485_abnormal_pinna_reflex0.80062036
145MP0005075_abnormal_melanosome_morpholog0.79588711
146MP0001664_abnormal_digestion0.78790551
147MP0005023_abnormal_wound_healing0.77426228
148MP0000681_abnormal_thyroid_gland0.76350678
149MP0001502_abnormal_circadian_rhythm0.75114085
150MP0003878_abnormal_ear_physiology0.74954684
151MP0005377_hearing/vestibular/ear_phenot0.74954684
152MP0001919_abnormal_reproductive_system0.74822463
153MP0000631_abnormal_neuroendocrine_gland0.74814204
154MP0000579_abnormal_nail_morphology0.74733965
155MP0003755_abnormal_palate_morphology0.73992773
156MP0005535_abnormal_body_temperature0.73966602
157MP0005551_abnormal_eye_electrophysiolog0.73439523
158MP0005381_digestive/alimentary_phenotyp0.73236253
159MP0002118_abnormal_lipid_homeostasis0.72065372
160MP0010678_abnormal_skin_adnexa0.71493172
161MP0004883_abnormal_blood_vessel0.71312684
162MP0001186_pigmentation_phenotype0.70761875
163MP0003937_abnormal_limbs/digits/tail_de0.70096259
164MP0005365_abnormal_bile_salt0.69779054
165MP0000465_gastrointestinal_hemorrhage0.67190058
166MP0001216_abnormal_epidermal_layer0.66485218
167MP0005275_abnormal_skin_tensile0.66194534
168MP0004484_altered_response_of0.65868008
169MP0003172_abnormal_lysosome_physiology0.64606418
170MP0000467_abnormal_esophagus_morphology0.63737345
171MP0004147_increased_porphyrin_level0.63434907
172MP0010352_gastrointestinal_tract_polyps0.63154435
173MP0001970_abnormal_pain_threshold0.63036506
174MP0003763_abnormal_thymus_physiology0.62666157
175MP0001529_abnormal_vocalization0.62520690
176MP0002128_abnormal_blood_circulation0.62047615
177MP0006276_abnormal_autonomic_nervous0.61433097
178MP0001835_abnormal_antigen_presentation0.60592544
179MP0005389_reproductive_system_phenotype0.60041608
180MP0001286_abnormal_eye_development0.58555252
181MP0005395_other_phenotype0.58322762
182MP0009379_abnormal_foot_pigmentation0.57781736
183MP0005595_abnormal_vascular_smooth0.57205404

Predicted human phenotypes

RankGene SetZ-score
1Purpura (HP:0000979)8.95797369
2Epistaxis (HP:0000421)7.75161673
3Gingival bleeding (HP:0000225)7.13667676
4Impaired platelet aggregation (HP:0003540)5.82429654
5Abnormal platelet function (HP:0011869)5.82429654
6Hyperlipoproteinemia (HP:0010980)4.78565002
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.58071958
8Spontaneous hematomas (HP:0007420)4.24988358
9Chromsome breakage (HP:0040012)3.88347077
10Poikilocytosis (HP:0004447)3.87702848
11Septo-optic dysplasia (HP:0100842)3.59063025
12Acanthocytosis (HP:0001927)3.58764491
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.55259912
14Eczematoid dermatitis (HP:0000976)3.40938786
15Bruising susceptibility (HP:0000978)3.32096963
16Prostate neoplasm (HP:0100787)3.21822661
17Abnormality of the axillary hair (HP:0100134)3.16489268
18Abnormality of secondary sexual hair (HP:0009888)3.16489268
19Parakeratosis (HP:0001036)3.11076129
20Aplasia cutis congenita (HP:0001057)3.06906400
21Pustule (HP:0200039)3.06215010
22Abnormality of the renal collecting system (HP:0004742)3.05829031
23Stomatitis (HP:0010280)3.01342427
24Increased IgE level (HP:0003212)3.00221807
25Duplicated collecting system (HP:0000081)2.99879605
26Abnormality of macrophages (HP:0004311)2.97934123
27Conjunctival telangiectasia (HP:0000524)2.95979916
28Abnormal pupillary function (HP:0007686)2.94058524
29Abnormality of the common coagulation pathway (HP:0010990)2.90581635
30Osteomalacia (HP:0002749)2.88880305
31True hermaphroditism (HP:0010459)2.81514818
32Pancreatic fibrosis (HP:0100732)2.79270620
33Dyschromatopsia (HP:0007641)2.78294700
34Abnormality of the vasculature of the conjunctiva (HP:0008054)2.78143808
35Paralysis (HP:0003470)2.77220286
36Lip pit (HP:0100267)2.75950688
37Nasolacrimal duct obstruction (HP:0000579)2.70355066
38Chronic obstructive pulmonary disease (HP:0006510)2.69830467
39Obstructive lung disease (HP:0006536)2.69830467
40Stomach cancer (HP:0012126)2.66179591
41Absent eyebrow (HP:0002223)2.65244302
42Increased density of long bones (HP:0006392)2.61103954
43White forelock (HP:0002211)2.58356614
44Abnormality of lateral ventricle (HP:0030047)2.55486135
45Hepatosplenomegaly (HP:0001433)2.55347788
46Abnormal ciliary motility (HP:0012262)2.53272390
47Conical tooth (HP:0000698)2.52737293
48Renal cortical cysts (HP:0000803)2.51226277
49Increased IgM level (HP:0003496)2.45168265
50Joint swelling (HP:0001386)2.44181639
51Abnormality of incisor morphology (HP:0011063)2.43621246
52Patchy hypopigmentation of hair (HP:0011365)2.43187473
53Hyperthyroidism (HP:0000836)2.40745300
54Submucous cleft hard palate (HP:0000176)2.38088629
55Abnormality of the lacrimal duct (HP:0011481)2.37684577
56Absent septum pellucidum (HP:0001331)2.34827084
57Abnormality of the preputium (HP:0100587)2.33507082
58Abnormal respiratory epithelium morphology (HP:0012253)2.33426483
59Abnormal respiratory motile cilium morphology (HP:0005938)2.33426483
60Pancreatic cysts (HP:0001737)2.31971568
61Popliteal pterygium (HP:0009756)2.31415647
62Optic nerve hypoplasia (HP:0000609)2.29381501
63Abnormal hair whorl (HP:0010721)2.28555229
64Congenital, generalized hypertrichosis (HP:0004540)2.26305084
65Abnormality of iron homeostasis (HP:0011031)2.24602883
66Abnormality of the septum pellucidum (HP:0007375)2.23203414
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22239956
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.21246597
69Absent/shortened dynein arms (HP:0200106)2.21246597
70Tubulointerstitial nephritis (HP:0001970)2.21080601
71Congenital sensorineural hearing impairment (HP:0008527)2.20713816
72Arterial thrombosis (HP:0004420)2.19204788
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18487524
74Median cleft lip (HP:0000161)2.16602011
75Retrobulbar optic neuritis (HP:0100654)2.16482816
76Optic neuritis (HP:0100653)2.16482816
77Tinnitus (HP:0000360)2.14601930
78Abnormal respiratory motile cilium physiology (HP:0012261)2.13749224
79Abnormality of the nasolacrimal system (HP:0000614)2.13199258
80Recurrent abscess formation (HP:0002722)2.11586242
81Episodic fever (HP:0001954)2.10893160
82Clubbing of toes (HP:0100760)2.08431286
83Abnormality of molar (HP:0011077)2.07856034
84Abnormality of molar morphology (HP:0011070)2.07856034
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.07732786
86Encephalitis (HP:0002383)2.07124497
87Aplasia/hypoplasia of the uterus (HP:0008684)2.05879974
88Corneal dystrophy (HP:0001131)2.04923855
89Recurrent bacterial skin infections (HP:0005406)2.03918781
90Adrenal hypoplasia (HP:0000835)2.03846128
91Aplasia of the musculature (HP:0100854)2.02610687
92Joint hemorrhage (HP:0005261)2.02570142
93Chest pain (HP:0100749)2.01631364
94Abnormal auditory evoked potentials (HP:0006958)2.01473909
95Autoimmune hemolytic anemia (HP:0001890)2.01472148
96Preaxial hand polydactyly (HP:0001177)2.01303751
97Prolonged bleeding time (HP:0003010)11.6180269
98Increased mean platelet volume (HP:0011877)10.4774874
99Petechiae (HP:0000967)10.3989813
100Menorrhagia (HP:0000132)10.3213973
101Abnormal platelet volume (HP:0011876)10.0117341
102Febrile seizures (HP:0002373)1.99906661
103Abnormality of renal resorption (HP:0011038)1.98020908
104Meckel diverticulum (HP:0002245)1.96562256
105Type I transferrin isoform profile (HP:0003642)1.93649209
106Xerostomia (HP:0000217)1.93049767
107Upper limb muscle weakness (HP:0003484)1.92857411
108Abnormality of the dental root (HP:0006486)1.92690442
109Taurodontia (HP:0000679)1.92690442
110Abnormality of permanent molar morphology (HP:0011071)1.92690442
111Abnormality of transition element cation homeostasis (HP:0011030)1.92254621
112Xanthomatosis (HP:0000991)1.90618610
113Hypoplasia of the fovea (HP:0007750)1.90558777
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.90558777
115Increased serum ferritin (HP:0003281)1.89924026
116Abnormality of the renal cortex (HP:0011035)1.89834410
117Abnormality of the ileum (HP:0001549)1.89702694
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89140893
119Elevated erythrocyte sedimentation rate (HP:0003565)1.88933212
120Abnormality of the renal medulla (HP:0100957)1.88717371
121Papillary thyroid carcinoma (HP:0002895)1.88504860
122Polycythemia (HP:0001901)1.87265600
123Leukocytosis (HP:0001974)1.86141907
124Spontaneous abortion (HP:0005268)1.84905207
125Medial flaring of the eyebrow (HP:0010747)1.84068066
126Hypergonadotropic hypogonadism (HP:0000815)1.83859255
127Pulmonary artery stenosis (HP:0004415)1.83737779
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.82785357
129Abnormality of the dental pulp (HP:0006479)1.81534842
130Vertigo (HP:0002321)1.80305592
131Renal dysplasia (HP:0000110)1.78713908
132Abnormality of the nasal septum (HP:0000419)1.76561526
133Short tibia (HP:0005736)1.76387828
134Congenital hepatic fibrosis (HP:0002612)1.75590786
135Inflammation of the large intestine (HP:0002037)1.75437702
136Reduced antithrombin III activity (HP:0001976)1.74897578
137Abnormality of cochlea (HP:0000375)1.74254276
138Birth length less than 3rd percentile (HP:0003561)1.73815685
139Male pseudohermaphroditism (HP:0000037)1.71627947
140Nephronophthisis (HP:0000090)1.71585127
141Ventricular fibrillation (HP:0001663)1.71231428
142Absent hand (HP:0004050)1.70878233
143Cheilitis (HP:0100825)1.70495871
144Split foot (HP:0001839)1.69496910
145Congenital ichthyosiform erythroderma (HP:0007431)1.69071561
146Duplication of thumb phalanx (HP:0009942)1.69002958
147Molar tooth sign on MRI (HP:0002419)1.68277928
148Abnormality of midbrain morphology (HP:0002418)1.68277928
149Decreased central vision (HP:0007663)1.67486157
150Capillary hemangiomas (HP:0005306)1.67209130
151Thrombocytosis (HP:0001894)1.64874433
152Hypergammaglobulinemia (HP:0010702)1.64673835
153Gastrointestinal inflammation (HP:0004386)1.64325370
154Urticaria (HP:0001025)1.62368032
155Oligohydramnios (HP:0001562)1.62093190
156Abnormality of the prostate (HP:0008775)1.61925694
157Postaxial foot polydactyly (HP:0001830)1.61147300
158Aplasia/Hypoplasia of the lens (HP:0008063)1.60449265
159Chronic hepatic failure (HP:0100626)1.59974706
160Onycholysis (HP:0001806)1.59512772
161Renal Fanconi syndrome (HP:0001994)1.58966049
162Hypothermia (HP:0002045)1.58219204
163Abnormal sex determination (HP:0012244)1.57940301
164Amaurosis fugax (HP:0100576)1.56864801
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.55401975
166Generalized aminoaciduria (HP:0002909)1.55221192
167Muscle fibrillation (HP:0010546)1.54109493
168Erythema (HP:0010783)1.53858675
169Nasal polyposis (HP:0100582)1.52312266
170Thrombophlebitis (HP:0004418)1.51081032
171Male infertility (HP:0003251)1.51025467
172Distal lower limb amyotrophy (HP:0008944)1.50940512
173Seborrheic dermatitis (HP:0001051)1.49855231
174Thyroid-stimulating hormone excess (HP:0002925)1.49011261
175Granulocytopenia (HP:0001913)1.48822695
176Myositis (HP:0100614)1.45259274
177Hypophosphatemic rickets (HP:0004912)1.45024361
178Tongue fasciculations (HP:0001308)1.44240928
179Panhypogammaglobulinemia (HP:0003139)1.44080198
180Chronic otitis media (HP:0000389)1.43985431
181Recurrent fungal infections (HP:0002841)1.43936680
182Nausea (HP:0002018)1.41562628
183Myocardial infarction (HP:0001658)1.40189258
184Dysautonomia (HP:0002459)1.39747919
185Recurrent viral infections (HP:0004429)1.38940508
186Vasculitis (HP:0002633)1.38387832
187Basal ganglia calcification (HP:0002135)1.38312201
188Cerebral ischemia (HP:0002637)1.38147629
189Microcytic anemia (HP:0001935)1.37328269
190Meningitis (HP:0001287)1.36385521
191Eosinophilia (HP:0001880)1.33190386
192Arthralgia (HP:0002829)1.30530956
193Dysostosis multiplex (HP:0000943)1.30023338
194Acne (HP:0001061)1.29227619
195Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.28499588
196Pulmonary embolism (HP:0002204)1.26027754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.56245210
2BMX3.88979527
3ZAK3.55280534
4CASK3.06306984
5IRAK32.79961096
6EIF2AK12.61226749
7AKT32.57425079
8IRAK42.48702642
9BLK2.48179802
10PTK2B2.44281723
11SYK2.43004617
12GRK62.42893322
13TIE12.42040827
14ZAP702.33698724
15INSRR2.23626886
16MKNK22.15082232
17GRK52.11767967
18TXK2.11754862
19PLK41.98793905
20CSF1R1.97064347
21TNIK1.96680094
22MAP2K31.93881277
23FGR1.91632185
24BMPR1B1.90678751
25NEK61.87748043
26STK38L1.85043911
27CDK31.81303009
28BMPR21.79014713
29EIF2AK21.77433057
30STK161.71982665
31GRK11.69298676
32PIK3CG1.68430763
33SIK31.64998052
34FES1.64316742
35HCK1.64088798
36MUSK1.58827491
37IRAK11.57227481
38EPHA21.56981632
39PRPF4B1.55915350
40MST41.54044036
41PIM21.52879150
42ADRBK21.48511181
43PBK1.45546745
44ILK1.40063910
45SRPK11.38181814
46YES11.36097709
47EPHA31.35954987
48MAP2K71.34896063
49MAP3K141.34380229
50KDR1.33437508
51MKNK11.29268516
52NUAK11.27646886
53CSK1.26208795
54NLK1.25854729
55ITK1.18684695
56GRK71.13803659
57MATK1.12640609
58VRK11.11106126
59PKN11.10738997
60IRAK21.09669110
61MAPK151.06881008
62ARAF1.06833364
63MAP4K11.06162112
64MAPKAPK31.03080751
65PINK10.99052649
66TAOK10.97218817
67PAK10.96428358
68TTK0.94852580
69MARK30.93462751
70STK240.89842322
71CLK10.88108233
72MAP3K50.87365970
73IKBKB0.85567871
74LMTK20.84671314
75TESK20.83887514
76PRKCE0.83537475
77DAPK20.82944444
78TEC0.80993879
79SGK20.80145978
80TGFBR20.76949541
81MAPK130.76076386
82RET0.75689762
83ERBB30.75675988
84JAK20.74692943
85DYRK20.74276795
86MAP3K110.74235601
87LCK0.73375385
88DAPK30.72957266
89ADRBK10.72603117
90PDK10.71841147
91TAOK30.70339306
92PIM10.69469253
93ACVR1B0.68588275
94OBSCN0.66865010
95CDK80.66686691
96MAPK70.63541455
97TNK20.62898298
98BCR0.62566667
99EPHB20.59854554
100PDGFRB0.59852274
101LATS10.59207537
102TRPM70.58289479
103IKBKE0.58223618
104SGK30.57118781
105PRKD10.56758345
106EIF2AK30.56129511
107JAK30.56096832
108CHUK0.55314999
109ERBB20.53964135
110MAP3K30.53610528
111PLK30.52602639
112STK30.52471261
113PDPK10.51957639
114MAPK120.51303481
115PRKCQ0.51298447
116RAF10.50959638
117TAOK20.49977860
118DYRK1A0.49518504
119EPHB10.49374737
120MAP3K10.49027416
121OXSR10.48994854
122FER0.48991866
123FYN0.48924913
124BRAF0.48913454
125TBK10.47611262
126MYLK0.47447716
127MAP2K10.45657789
128JAK10.45651063
129SGK4940.45580038
130SGK2230.45580038
131PRKACG0.45280860
132LYN0.45206327
133HIPK20.44120256
134PDK20.42072851
135MAPKAPK50.40393080
136LRRK20.39956623
137MAP3K120.39417011
138FRK0.38806100
139RPS6KA50.37687347
140PRKD20.37589410
141KIT0.36421827
142PRKCD0.36180472
143MAP3K20.35704571
144MST1R0.35056651
145CCNB10.34547478
146PLK10.33886035
147CHEK20.32072244
148STK390.31629100
149PLK20.31457776
150ERBB40.31349610
151MARK20.31331726
152CAMK10.30615051
153BUB10.29296133
154CAMK2A0.29134852
155FLT30.28927475
156TLK10.28788349
157PRKG10.27889703
158STK40.26992405
159BRD40.26881707
160BTK0.26368621
161CSNK1A10.26051756
162CDK90.25841969
163DAPK10.25652155
164DYRK1B0.25086799
165CAMK1G0.22547656

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.28361602
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.65722119
3Sphingolipid metabolism_Homo sapiens_hsa006002.49563715
4RNA polymerase_Homo sapiens_hsa030202.42800280
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39359589
6Fanconi anemia pathway_Homo sapiens_hsa034602.28188576
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25732788
8Chemokine signaling pathway_Homo sapiens_hsa040622.00974890
9* Arachidonic acid metabolism_Homo sapiens_hsa005902.00311700
10Graft-versus-host disease_Homo sapiens_hsa053321.92248929
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91829778
12Vitamin B6 metabolism_Homo sapiens_hsa007501.88823227
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83841884
14Basal transcription factors_Homo sapiens_hsa030221.81333550
15Ether lipid metabolism_Homo sapiens_hsa005651.74139482
16Nitrogen metabolism_Homo sapiens_hsa009101.70826196
17B cell receptor signaling pathway_Homo sapiens_hsa046621.69807707
18Linoleic acid metabolism_Homo sapiens_hsa005911.69470540
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65699087
20Autoimmune thyroid disease_Homo sapiens_hsa053201.64747708
21Homologous recombination_Homo sapiens_hsa034401.59396167
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56348127
23Vitamin digestion and absorption_Homo sapiens_hsa049771.51358300
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50810963
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50126794
26Osteoclast differentiation_Homo sapiens_hsa043801.48508251
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47203602
28Nicotine addiction_Homo sapiens_hsa050331.46896086
29Rheumatoid arthritis_Homo sapiens_hsa053231.45536727
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44170658
31Allograft rejection_Homo sapiens_hsa053301.43844685
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41721560
33Other glycan degradation_Homo sapiens_hsa005111.40638901
34Regulation of autophagy_Homo sapiens_hsa041401.39320661
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.38794563
36Gap junction_Homo sapiens_hsa045401.38678856
37T cell receptor signaling pathway_Homo sapiens_hsa046601.36852789
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36795800
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36036555
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.34681369
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34069831
42Endocytosis_Homo sapiens_hsa041441.33903465
43Shigellosis_Homo sapiens_hsa051311.33660779
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.32133872
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30949871
46Phototransduction_Homo sapiens_hsa047441.27349773
47Taste transduction_Homo sapiens_hsa047421.22370900
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.21890559
49Staphylococcus aureus infection_Homo sapiens_hsa051501.19396834
50Non-homologous end-joining_Homo sapiens_hsa034501.18911309
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18031060
52Protein export_Homo sapiens_hsa030601.17722228
53Systemic lupus erythematosus_Homo sapiens_hsa053221.13358694
54Hematopoietic cell lineage_Homo sapiens_hsa046401.11158490
55Purine metabolism_Homo sapiens_hsa002301.10861366
56Proteasome_Homo sapiens_hsa030501.08846206
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06107008
58Pyrimidine metabolism_Homo sapiens_hsa002401.06044931
59Glycerolipid metabolism_Homo sapiens_hsa005611.03188644
60p53 signaling pathway_Homo sapiens_hsa041151.02956910
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01917434
62Asthma_Homo sapiens_hsa053101.00233390
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97408460
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97125687
65Alcoholism_Homo sapiens_hsa050340.96662657
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96478640
67Circadian rhythm_Homo sapiens_hsa047100.95616971
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.95364199
69Long-term depression_Homo sapiens_hsa047300.95186834
70Pancreatic cancer_Homo sapiens_hsa052120.93172048
71Acute myeloid leukemia_Homo sapiens_hsa052210.93137023
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91773348
73Non-small cell lung cancer_Homo sapiens_hsa052230.91550852
74Pancreatic secretion_Homo sapiens_hsa049720.90472321
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90097445
76Malaria_Homo sapiens_hsa051440.89531302
77Tuberculosis_Homo sapiens_hsa051520.89114136
78Collecting duct acid secretion_Homo sapiens_hsa049660.87839670
79* Serotonergic synapse_Homo sapiens_hsa047260.86903807
80Retinol metabolism_Homo sapiens_hsa008300.86248899
81Oxidative phosphorylation_Homo sapiens_hsa001900.85905311
82Rap1 signaling pathway_Homo sapiens_hsa040150.84268388
83African trypanosomiasis_Homo sapiens_hsa051430.80705719
84Salivary secretion_Homo sapiens_hsa049700.80013274
85Ovarian steroidogenesis_Homo sapiens_hsa049130.79830423
86Measles_Homo sapiens_hsa051620.79258754
87Legionellosis_Homo sapiens_hsa051340.78693638
88Primary immunodeficiency_Homo sapiens_hsa053400.77785476
89RNA degradation_Homo sapiens_hsa030180.77461376
90Choline metabolism in cancer_Homo sapiens_hsa052310.76380964
91Olfactory transduction_Homo sapiens_hsa047400.75248590
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74035622
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73600456
94Herpes simplex infection_Homo sapiens_hsa051680.73146438
95Glutathione metabolism_Homo sapiens_hsa004800.72023346
96Viral carcinogenesis_Homo sapiens_hsa052030.70075286
97Salmonella infection_Homo sapiens_hsa051320.69527877
98Sulfur metabolism_Homo sapiens_hsa009200.69348346
99Focal adhesion_Homo sapiens_hsa045100.68730677
100Mineral absorption_Homo sapiens_hsa049780.66206096
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65362735
102Cell cycle_Homo sapiens_hsa041100.64812859
103Amoebiasis_Homo sapiens_hsa051460.64757903
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.64724935
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64531352
106Morphine addiction_Homo sapiens_hsa050320.64425869
107Fatty acid elongation_Homo sapiens_hsa000620.63902323
108Nucleotide excision repair_Homo sapiens_hsa034200.63784788
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63077618
110Endometrial cancer_Homo sapiens_hsa052130.61876971
111Apoptosis_Homo sapiens_hsa042100.61740637
112Toxoplasmosis_Homo sapiens_hsa051450.61014343
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60526023
114Base excision repair_Homo sapiens_hsa034100.60425683
115Small cell lung cancer_Homo sapiens_hsa052220.59775117
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59649325
117Axon guidance_Homo sapiens_hsa043600.58909299
118Renal cell carcinoma_Homo sapiens_hsa052110.58179943
119Calcium signaling pathway_Homo sapiens_hsa040200.57460535
120TNF signaling pathway_Homo sapiens_hsa046680.57430212
121Chronic myeloid leukemia_Homo sapiens_hsa052200.57028801
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.56605755
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.56546264
124VEGF signaling pathway_Homo sapiens_hsa043700.56321450
125Histidine metabolism_Homo sapiens_hsa003400.55510467
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54139119
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53334509
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.52888129
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.52421013
130Influenza A_Homo sapiens_hsa051640.52113552
131Renin-angiotensin system_Homo sapiens_hsa046140.51787502
132Phagosome_Homo sapiens_hsa041450.51289672
133Circadian entrainment_Homo sapiens_hsa047130.50698015
134Steroid biosynthesis_Homo sapiens_hsa001000.49993059
135Huntingtons disease_Homo sapiens_hsa050160.49710573
136beta-Alanine metabolism_Homo sapiens_hsa004100.49206002
137Leishmaniasis_Homo sapiens_hsa051400.47107204
138Renin secretion_Homo sapiens_hsa049240.46954250
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46705296
140* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46636495
141TGF-beta signaling pathway_Homo sapiens_hsa043500.46422644
142Notch signaling pathway_Homo sapiens_hsa043300.46190299
143ABC transporters_Homo sapiens_hsa020100.45617289
144Ras signaling pathway_Homo sapiens_hsa040140.45447903
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45021148
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43830058
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43529954
148Inositol phosphate metabolism_Homo sapiens_hsa005620.42632632
149ECM-receptor interaction_Homo sapiens_hsa045120.42393622
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42190132
151Glutamatergic synapse_Homo sapiens_hsa047240.41617861
152Hepatitis B_Homo sapiens_hsa051610.41240536
153Basal cell carcinoma_Homo sapiens_hsa052170.38415571
154Wnt signaling pathway_Homo sapiens_hsa043100.36741512
155Adherens junction_Homo sapiens_hsa045200.36695875
156Arginine and proline metabolism_Homo sapiens_hsa003300.36378067
157* Metabolic pathways_Homo sapiens_hsa011000.35724478
158Melanoma_Homo sapiens_hsa052180.34514253

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