ALOX12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.55540569
2peptide cross-linking (GO:0018149)8.85332030
3* multicellular organismal water homeostasis (GO:0050891)8.64436792
4detection of other organism (GO:0098543)8.32417421
5hair cycle (GO:0042633)7.18430559
6molting cycle (GO:0042303)7.18430559
7* water homeostasis (GO:0030104)7.13278819
8epidermal cell differentiation (GO:0009913)7.12564306
9keratinocyte proliferation (GO:0043616)7.10890138
10regulation of natural killer cell differentiation (GO:0032823)7.03676640
11hemidesmosome assembly (GO:0031581)6.81564081
12bundle of His cell to Purkinje myocyte communication (GO:0086069)6.26957848
13negative regulation of interferon-gamma production (GO:0032689)5.97071227
14epidermis development (GO:0008544)5.92301067
15gap junction assembly (GO:0016264)5.62004762
16intermediate filament organization (GO:0045109)5.43367278
17regulation of transforming growth factor beta1 production (GO:0032908)5.34501536
18glucosamine-containing compound catabolic process (GO:1901072)5.25915154
19fatty acid elongation (GO:0030497)5.23525581
20skin morphogenesis (GO:0043589)5.17613013
21positive regulation of monocyte chemotaxis (GO:0090026)5.15395882
22* lipoxygenase pathway (GO:0019372)5.13682034
23regulation of ruffle assembly (GO:1900027)4.91355184
24sequestering of metal ion (GO:0051238)4.85430163
25ectoderm development (GO:0007398)4.83998800
26sphingoid metabolic process (GO:0046519)4.80963846
27phosphatidylserine metabolic process (GO:0006658)4.80098022
28chemical homeostasis within a tissue (GO:0048875)4.77175965
29detection of external biotic stimulus (GO:0098581)4.77026843
30positive regulation of T cell chemotaxis (GO:0010820)4.69610893
31regulation of T cell chemotaxis (GO:0010819)4.69610893
32positive regulation of glomerulus development (GO:0090193)4.64184816
33negative regulation of interleukin-17 production (GO:0032700)4.54065447
34* long-chain fatty acid biosynthetic process (GO:0042759)4.52407499
35* linoleic acid metabolic process (GO:0043651)4.34019277
36regulation of cell proliferation involved in kidney development (GO:1901722)4.27934429
37phospholipid catabolic process (GO:0009395)4.19991821
38detection of biotic stimulus (GO:0009595)4.19362661
39sphingosine metabolic process (GO:0006670)3.96325622
40alditol phosphate metabolic process (GO:0052646)3.90450800
41chemosensory behavior (GO:0007635)3.84408491
42long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.83138225
43regulation of monocyte chemotaxis (GO:0090025)3.74594649
44surfactant homeostasis (GO:0043129)3.63220075
45positive regulation of epidermis development (GO:0045684)3.62968476
46polarized epithelial cell differentiation (GO:0030859)3.57707772
47intermediate filament cytoskeleton organization (GO:0045104)3.56815370
48diol metabolic process (GO:0034311)3.50160760
49intermediate filament-based process (GO:0045103)3.48287067
50positive regulation of epidermal cell differentiation (GO:0045606)3.46178699
51skin development (GO:0043588)3.34299765
52phosphatidylinositol acyl-chain remodeling (GO:0036149)3.33725861
53establishment of planar polarity (GO:0001736)3.33038556
54establishment of tissue polarity (GO:0007164)3.33038556
55epithelial cell differentiation involved in prostate gland development (GO:0060742)3.29142930
56positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.29016691
57regulation of natural killer cell activation (GO:0032814)3.28809310
58keratinocyte development (GO:0003334)3.26953654
59fatty-acyl-CoA metabolic process (GO:0035337)3.24052752
60eyelid development in camera-type eye (GO:0061029)3.19381342
61cell wall macromolecule catabolic process (GO:0016998)3.16077680
62cell wall macromolecule metabolic process (GO:0044036)3.16077680
63regulation of neuron projection regeneration (GO:0070570)3.15295129
64regulation of axon regeneration (GO:0048679)3.15295129
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.07456422
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06730133
67lateral sprouting from an epithelium (GO:0060601)3.06628400
68ventricular cardiac muscle cell action potential (GO:0086005)3.02774761
69positive regulation of keratinocyte differentiation (GO:0045618)3.01669798
70positive regulation of vesicle fusion (GO:0031340)3.01580225
71negative regulation of keratinocyte proliferation (GO:0010839)3.00254716
72keratinization (GO:0031424)20.0176431
73regulation of glomerulus development (GO:0090192)2.99061195
74epithelial cell differentiation (GO:0030855)2.96940455
75negative regulation of stress fiber assembly (GO:0051497)2.95152319
76defense response to fungus (GO:0050832)2.94501402
77regulation of epidermis development (GO:0045682)2.90649214
78cardiolipin metabolic process (GO:0032048)2.89162812
79positive regulation of transforming growth factor beta production (GO:0071636)2.88536223
80cell communication involved in cardiac conduction (GO:0086065)2.85842657
81positive regulation of granulocyte chemotaxis (GO:0071624)2.84647030
82phosphatidylserine acyl-chain remodeling (GO:0036150)2.84213458
83cyclooxygenase pathway (GO:0019371)2.82060660
84phospholipid efflux (GO:0033700)2.81938013
85ephrin receptor signaling pathway (GO:0048013)2.81741815
86prostaglandin biosynthetic process (GO:0001516)2.80571234
87prostanoid biosynthetic process (GO:0046457)2.80571234
88phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.80220941
89G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75078380
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74247360
91* ceramide biosynthetic process (GO:0046513)2.73841924
92defense response to Gram-negative bacterium (GO:0050829)2.72629568
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.72078936
94regulation of lymphocyte chemotaxis (GO:1901623)2.72055120
95regulation of heart rate by cardiac conduction (GO:0086091)2.68127672
96sarcoplasmic reticulum calcium ion transport (GO:0070296)2.67862369
97epithelium development (GO:0060429)2.66072767
98positive regulation of interleukin-8 secretion (GO:2000484)2.65160972
99hair follicle morphogenesis (GO:0031069)2.64723360
100plasma membrane repair (GO:0001778)2.60905510
101antimicrobial humoral response (GO:0019730)2.60261289
102regulation of epidermal cell differentiation (GO:0045604)2.59635333
103negative regulation of lymphocyte differentiation (GO:0045620)2.58105531
104phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.57176068
105regulation of keratinocyte proliferation (GO:0010837)2.56808641
106negative regulation of actin filament bundle assembly (GO:0032232)2.55330450
107response to UV-B (GO:0010224)2.54164607
108phosphatidic acid biosynthetic process (GO:0006654)2.53198818
109phosphatidic acid metabolic process (GO:0046473)2.53198818
110long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.52526313
111detection of bacterium (GO:0016045)2.51334320
112phosphatidylglycerol metabolic process (GO:0046471)2.49515962
113positive regulation of cholesterol transport (GO:0032376)2.46964034
114positive regulation of sterol transport (GO:0032373)2.46964034
115regulation of interleukin-17 production (GO:0032660)2.45905162
116regulation of protein localization to cell surface (GO:2000008)2.42392438
117glutathione biosynthetic process (GO:0006750)2.41658597
118positive regulation of cholesterol efflux (GO:0010875)2.38840790
119regulation of keratinocyte differentiation (GO:0045616)2.38441328
120virion attachment to host cell (GO:0019062)2.38366009
121adhesion of symbiont to host cell (GO:0044650)2.38366009
122cardiac conduction (GO:0061337)2.38352769
123positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.36778109
124negative regulation of cell fate specification (GO:0009996)2.35155143
125regulation of phospholipase A2 activity (GO:0032429)2.34984024
126fibrinolysis (GO:0042730)2.33891198
127cell-substrate junction assembly (GO:0007044)2.32157794
128muscle filament sliding (GO:0030049)2.31915142
129actin-myosin filament sliding (GO:0033275)2.31915142
130positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.31412095
131regulation of cholesterol homeostasis (GO:2000188)2.31320452
132fatty-acyl-CoA biosynthetic process (GO:0046949)2.30490949
133intestinal epithelial cell development (GO:0060576)2.30345012
134epithelial cell-cell adhesion (GO:0090136)2.30059097
135phospholipid scrambling (GO:0017121)2.28258052
136regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.27939763
137* sphingolipid biosynthetic process (GO:0030148)2.25060675
138phosphatidylcholine acyl-chain remodeling (GO:0036151)2.22643225
139regulation of hair cycle (GO:0042634)2.21172866
140cellular response to calcium ion (GO:0071277)2.20995709
141regulation of cardioblast differentiation (GO:0051890)2.20510537
142nonribosomal peptide biosynthetic process (GO:0019184)2.18037484
143mitotic G1 DNA damage checkpoint (GO:0031571)2.17901316
144atrioventricular valve morphogenesis (GO:0003181)2.17137037
145phosphatidylcholine metabolic process (GO:0046470)2.14926871
146positive regulation of T cell migration (GO:2000406)2.14596304
147* establishment of skin barrier (GO:0061436)14.8509574
148desmosome organization (GO:0002934)14.1253763
149* regulation of water loss via skin (GO:0033561)12.9677491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.78284006
2P63_26484246_Chip-Seq_KERATINOCYTES_Human2.91306100
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.90386485
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.35118761
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.18920638
6ZNF263_19887448_ChIP-Seq_K562_Human2.14259806
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06854234
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.03720868
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.8668598
10TRIM28_21343339_ChIP-Seq_HEK293_Human1.91267825
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80867675
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67082086
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.63852922
14TCF4_18268006_ChIP-ChIP_LS174T_Human1.62168661
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61981916
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61981916
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58906171
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52092171
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49923965
20EZH2_22144423_ChIP-Seq_EOC_Human1.49259992
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48968763
22* SMC4_20622854_ChIP-Seq_HELA_Human1.47543906
23RXR_22108803_ChIP-Seq_LS180_Human1.47415728
24CTCF_27219007_Chip-Seq_Bcells_Human1.43421893
25TP63_23658742_ChIP-Seq_EP156T_Human1.41860461
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41648067
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40793303
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40677424
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39572374
30GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.38332795
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35675530
32TP63_22573176_ChIP-Seq_HFKS_Human1.35415726
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33003184
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31765007
35TP53_18474530_ChIP-ChIP_U2OS_Human1.31674987
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.31468016
37* E2F1_20622854_ChIP-Seq_HELA_Human1.30820441
38* BCOR_27268052_Chip-Seq_Bcells_Human1.30497575
39GATA6_21074721_ChIP-Seq_CACO-2_Human1.29518715
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.29214851
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27652944
42SOX2_20726797_ChIP-Seq_SW620_Human1.27559181
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25122173
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25122173
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24703391
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23493865
47* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23024825
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.18934617
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.18545809
50* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18268574
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18233474
52KLF5_25053715_ChIP-Seq_YYC3_Human1.17604660
53CJUN_26792858_Chip-Seq_BT549_Human1.17102199
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.17052948
55* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15825608
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.14860453
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13939818
58AR_21572438_ChIP-Seq_LNCaP_Human1.13015771
59* P68_20966046_ChIP-Seq_HELA_Human1.11620937
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10969862
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.09460499
62BCL6_27268052_Chip-Seq_Bcells_Human1.08822361
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08602867
64RACK7_27058665_Chip-Seq_MCF-7_Human1.06059714
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05514654
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04242238
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04105443
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.03721511
69VDR_22108803_ChIP-Seq_LS180_Human1.02879057
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.01223059
71P53_21459846_ChIP-Seq_SAOS-2_Human1.01188792
72KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98000545
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97419853
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96739993
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95906565
76GATA6_25053715_ChIP-Seq_YYC3_Human0.95894085
77TP53_16413492_ChIP-PET_HCT116_Human0.95865903
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95856343
79ATF3_27146783_Chip-Seq_COLON_Human0.95536987
80AHR_22903824_ChIP-Seq_MCF-7_Human0.95419789
81DROSHA_22980978_ChIP-Seq_HELA_Human0.94962987
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92050759
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92020083
84KDM2B_26808549_Chip-Seq_K562_Human0.91908071
85BCAT_22108803_ChIP-Seq_LS180_Human0.91367339
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91348018
87CTCF_20526341_ChIP-Seq_ESCs_Human0.90976640
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89851083
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89462044
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89416796
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89145378
92CLOCK_20551151_ChIP-Seq_293T_Human0.89035872
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88988153
94* CEBPB_22108803_ChIP-Seq_LS180_Human0.88667724
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88018087
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87818328
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.87070893
98TCF7_22412390_ChIP-Seq_EML_Mouse0.86546849
99* SA1_27219007_Chip-Seq_ERYTHROID_Human0.85599630
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85360701
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85310159
102P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85181876
103CREB1_26743006_Chip-Seq_LNCaP_Human0.84239957
104LXR_22292898_ChIP-Seq_THP-1_Human0.84040112
105AR_25329375_ChIP-Seq_VCAP_Human0.82499817
106RBPJ_21746931_ChIP-Seq_IB4_Human0.82409294
107SPI1_20517297_ChIP-Seq_HL60_Human0.81781096
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81492323
109* KDM2B_26808549_Chip-Seq_DND41_Human0.81159454
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.80622997
111TCF4_22108803_ChIP-Seq_LS180_Human0.80503593
112* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79216981
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.79051388
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78248627
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77548305
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77385592
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76902248
118* OCT1_27270436_Chip-Seq_PROSTATE_Human0.76812871
119TAF2_19829295_ChIP-Seq_ESCs_Human0.76701414
120* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76468366
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75866106
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74421318
123HNFA_21074721_ChIP-Seq_CACO-2_Human0.74398307
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.74190642
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73116278
126ERG_20517297_ChIP-Seq_VCAP_Human0.72592529
127RARB_27405468_Chip-Seq_BRAIN_Mouse0.71800234
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71718443
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71181348
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.71018750
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70808728
132PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70029944
133FOXH1_21741376_ChIP-Seq_ESCs_Human0.70004894
134SA1_27219007_Chip-Seq_Bcells_Human0.69521553
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69334178
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69332586
137CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69096105
138GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.68474786
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.68094487
140* P300_27268052_Chip-Seq_Bcells_Human0.66794803
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66643474
142* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65922708
143EGR1_19032775_ChIP-ChIP_M12_Human0.65557438
144NANOG_20526341_ChIP-Seq_ESCs_Human0.65450675
145GATA4_25053715_ChIP-Seq_YYC3_Human0.64605552
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64367197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier8.58606500
2MP0005275_abnormal_skin_tensile6.67848027
3MP0003941_abnormal_skin_development5.82081136
4MP0010234_abnormal_vibrissa_follicle5.71083842
5* MP0005501_abnormal_skin_physiology5.28907687
6MP0000579_abnormal_nail_morphology3.95451003
7MP0005451_abnormal_body_composition3.40527522
8* MP0001216_abnormal_epidermal_layer3.19807062
9* MP0010771_integument_phenotype3.17192530
10MP0002060_abnormal_skin_morphology3.03238256
11MP0003878_abnormal_ear_physiology2.96028032
12MP0005377_hearing/vestibular/ear_phenot2.96028032
13MP0004885_abnormal_endolymph2.83265249
14MP0004947_skin_inflammation2.78461680
15MP0003453_abnormal_keratinocyte_physiol2.77504283
16MP0000467_abnormal_esophagus_morphology2.75674347
17MP0004381_abnormal_hair_follicle2.64479112
18MP0010678_abnormal_skin_adnexa2.58609891
19MP0000647_abnormal_sebaceous_gland2.40756770
20MP0002254_reproductive_system_inflammat2.35557765
21MP0000383_abnormal_hair_follicle2.34085185
22MP0000566_synostosis2.17151014
23MP0003705_abnormal_hypodermis_morpholog2.04476472
24MP0000762_abnormal_tongue_morphology1.98473688
25MP0003191_abnormal_cellular_cholesterol1.96219702
26MP0002098_abnormal_vibrissa_morphology1.93334649
27MP0000377_abnormal_hair_follicle1.92983584
28MP0000427_abnormal_hair_cycle1.92267518
29MP0004264_abnormal_extraembryonic_tissu1.85073911
30MP0004185_abnormal_adipocyte_glucose1.77982626
31MP0002234_abnormal_pharynx_morphology1.66703569
32* MP0009931_abnormal_skin_appearance1.65884402
33* MP0001191_abnormal_skin_condition1.46594917
34MP0003566_abnormal_cell_adhesion1.44631624
35MP0001243_abnormal_dermal_layer1.38232910
36MP0003011_delayed_dark_adaptation1.24334252
37MP0001188_hyperpigmentation1.23842543
38MP0000367_abnormal_coat/_hair1.19692257
39MP0004859_abnormal_synaptic_plasticity1.11175365
40MP0003329_amyloid_beta_deposits1.07508240
41MP0001346_abnormal_lacrimal_gland0.99017466
42MP0004782_abnormal_surfactant_physiolog0.98238813
43MP0003880_abnormal_central_pattern0.97353446
44MP0001851_eye_inflammation0.96629633
45MP0001984_abnormal_olfaction0.95458146
46MP0004270_analgesia0.91924149
47MP0000751_myopathy0.86469139
48MP0008004_abnormal_stomach_pH0.85129925
49MP0009379_abnormal_foot_pigmentation0.77435369
50MP0003950_abnormal_plasma_membrane0.76222594
51MP0001340_abnormal_eyelid_morphology0.75912519
52MP0002009_preneoplasia0.74375015
53MP0000465_gastrointestinal_hemorrhage0.70974401
54MP0002095_abnormal_skin_pigmentation0.68756463
55MP0008961_abnormal_basal_metabolism0.66467506
56MP0001968_abnormal_touch/_nociception0.65271346
57* MP0001784_abnormal_fluid_regulation0.61355863
58MP0002177_abnormal_outer_ear0.60943814
59MP0003635_abnormal_synaptic_transmissio0.60300814
60MP0001177_atelectasis0.60204264
61MP0000749_muscle_degeneration0.59883899
62MP0004858_abnormal_nervous_system0.59352525
63MP0003763_abnormal_thymus_physiology0.57288023
64MP0000015_abnormal_ear_pigmentation0.56563888
65MP0002736_abnormal_nociception_after0.55320032
66MP0002837_dystrophic_cardiac_calcinosis0.53553964
67MP0002877_abnormal_melanocyte_morpholog0.51469604
68MP0000747_muscle_weakness0.50936256
69MP0002063_abnormal_learning/memory/cond0.49970804
70MP0004145_abnormal_muscle_electrophysio0.49559449
71MP0004043_abnormal_pH_regulation0.49397920
72MP0005409_darkened_coat_color0.48314506
73MP0010352_gastrointestinal_tract_polyps0.47175617
74MP0009780_abnormal_chondrocyte_physiolo0.45825578
75MP0005666_abnormal_adipose_tissue0.45046931
76MP0005076_abnormal_cell_differentiation0.44512354
77MP0001849_ear_inflammation0.44201939
78MP0002111_abnormal_tail_morphology0.43911433
79MP0002138_abnormal_hepatobiliary_system0.42035985
80MP0009333_abnormal_splenocyte_physiolog0.41525478
81MP0009745_abnormal_behavioral_response0.41446413
82MP0005174_abnormal_tail_pigmentation0.37689810
83MP0000604_amyloidosis0.37376782
84MP0005620_abnormal_muscle_contractility0.36685960
85MP0004197_abnormal_fetal_growth/weight/0.36368677
86MP0001485_abnormal_pinna_reflex0.35932295
87MP0008569_lethality_at_weaning0.35040423
88MP0003755_abnormal_palate_morphology0.34430738
89MP0000759_abnormal_skeletal_muscle0.34172809
90MP0002064_seizures0.33225955
91MP0001299_abnormal_eye_distance/0.32256341
92MP0001501_abnormal_sleep_pattern0.32158138
93MP0000685_abnormal_immune_system0.31956394
94MP0008260_abnormal_autophagy0.31544824
95MP0000470_abnormal_stomach_morphology0.31417894
96MP0005375_adipose_tissue_phenotype0.31306357
97MP0005394_taste/olfaction_phenotype0.30698272
98MP0005499_abnormal_olfactory_system0.30698272
99MP0002090_abnormal_vision0.30568745
100MP0003315_abnormal_perineum_morphology0.30370416
101MP0000750_abnormal_muscle_regeneration0.30321412
102MP0002106_abnormal_muscle_physiology0.29116748
103MP0005023_abnormal_wound_healing0.28713258
104MP0004087_abnormal_muscle_fiber0.27861756
105MP0010386_abnormal_urinary_bladder0.27484530
106MP0010030_abnormal_orbit_morphology0.26118832
107MP0001440_abnormal_grooming_behavior0.25184928
108MP0009053_abnormal_anal_canal0.25012367
109MP0009046_muscle_twitch0.24792063
110MP0008789_abnormal_olfactory_epithelium0.24453648
111MP0000013_abnormal_adipose_tissue0.24398261
112MP0005369_muscle_phenotype0.24291246
113MP0002006_tumorigenesis0.23353943
114MP0009672_abnormal_birth_weight0.23070468
115MP0005388_respiratory_system_phenotype0.22422955
116MP0002133_abnormal_respiratory_system0.22422955
117MP0001765_abnormal_ion_homeostasis0.21979511
118MP0000003_abnormal_adipose_tissue0.21656189
119MP0003638_abnormal_response/metabolism_0.21600018
120MP0000858_altered_metastatic_potential0.21039995
121MP0000627_abnormal_mammary_gland0.20959763
122MP0001186_pigmentation_phenotype0.20950642
123MP0005075_abnormal_melanosome_morpholog0.20582545
124MP0004484_altered_response_of0.20216997
125MP0002572_abnormal_emotion/affect_behav0.20103378
126MP0003045_fibrosis0.20035980
127MP0003436_decreased_susceptibility_to0.16043479
128MP0002166_altered_tumor_susceptibility0.15980523
129MP0005503_abnormal_tendon_morphology0.15534551
130MP0002697_abnormal_eye_size0.13986703
131MP0005193_abnormal_anterior_eye0.11237884
132MP0002282_abnormal_trachea_morphology0.11220685
133MP0002233_abnormal_nose_morphology0.08724223
134MP0000432_abnormal_head_morphology0.07723161
135MP0008438_abnormal_cutaneous_collagen0.07489187
136MP0002019_abnormal_tumor_incidence0.05650298
137MP0000428_abnormal_craniofacial_morphol0.04430473
138MP0003448_altered_tumor_morphology0.04346975
139MP0003300_gastrointestinal_ulcer0.04207842
140MP0009115_abnormal_fat_cell0.03792781

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.76736302
2Abnormality of nail color (HP:0100643)8.12106941
3Hypotrichosis (HP:0001006)7.02031777
4* Congenital ichthyosiform erythroderma (HP:0007431)6.97960004
5Palmoplantar hyperkeratosis (HP:0000972)6.46696295
6Plantar hyperkeratosis (HP:0007556)6.35755154
7Right ventricular cardiomyopathy (HP:0011663)6.19044467
8Palmar hyperkeratosis (HP:0010765)6.07588242
9Erythroderma (HP:0001019)5.99294804
10Conjunctival hamartoma (HP:0100780)5.87407624
11Erythema (HP:0010783)5.81664037
12Woolly hair (HP:0002224)5.78719498
13Lip pit (HP:0100267)5.39306483
14Onycholysis (HP:0001806)5.35702463
15* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.32026523
16Oral leukoplakia (HP:0002745)4.70604019
17Thick nail (HP:0001805)4.67814598
18Fragile nails (HP:0001808)4.44272539
19Hyporeflexia of lower limbs (HP:0002600)4.27826373
20Abnormal blistering of the skin (HP:0008066)4.14353708
21Pili torti (HP:0003777)4.01620297
22Parakeratosis (HP:0001036)4.01044451
23* Gangrene (HP:0100758)3.87068942
24Milia (HP:0001056)3.80777650
25Hamartoma of the eye (HP:0010568)3.80546102
26* Palmoplantar keratoderma (HP:0000982)3.76604781
27Absent eyelashes (HP:0000561)3.72404881
28* Ectropion (HP:0000656)3.63194261
29* Corneal erosion (HP:0200020)3.50952921
30Absent hair (HP:0002298)3.48003153
31Distal lower limb muscle weakness (HP:0009053)3.33205158
32Nail dystrophy (HP:0008404)3.30694109
33Pustule (HP:0200039)3.29872370
34* Hypohidrosis (HP:0000966)3.25570929
35Curly hair (HP:0002212)3.19311086
36Amniotic constriction ring (HP:0009775)3.09709493
37Abnormality of placental membranes (HP:0011409)3.09709493
38Exercise-induced myalgia (HP:0003738)3.08679682
39Furrowed tongue (HP:0000221)3.08504013
40Ventricular tachycardia (HP:0004756)3.06061694
41Abnormality of the salivary glands (HP:0010286)3.05642007
42* Pruritus (HP:0000989)3.03816981
43Areflexia of lower limbs (HP:0002522)3.03707884
44Distal arthrogryposis (HP:0005684)2.82090172
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.76315878
46Muscle fiber inclusion bodies (HP:0100299)2.73471073
47Advanced eruption of teeth (HP:0006288)2.73370649
48Increased connective tissue (HP:0009025)2.72295468
49Alopecia of scalp (HP:0002293)2.66692462
50Round ear (HP:0100830)2.64774689
51Nemaline bodies (HP:0003798)2.60423437
52Natal tooth (HP:0000695)2.59926788
53Autoamputation (HP:0001218)2.58460123
54Type 1 muscle fiber predominance (HP:0003803)2.51287470
55Abnormal hair laboratory examination (HP:0003328)2.49649917
56Popliteal pterygium (HP:0009756)2.48633767
57Hypergammaglobulinemia (HP:0010702)2.45594211
58Sparse eyelashes (HP:0000653)2.44850260
59Ventricular fibrillation (HP:0001663)2.37897716
60Acanthosis nigricans (HP:0000956)2.37170951
61Myopathic facies (HP:0002058)2.36861935
62Sparse scalp hair (HP:0002209)2.34107805
63Malignant hyperthermia (HP:0002047)2.28616463
64Follicular hyperkeratosis (HP:0007502)2.27732362
65Multifactorial inheritance (HP:0001426)2.25673108
66Sudden death (HP:0001699)2.23122804
67Achilles tendon contracture (HP:0001771)2.18570663
68Abnormality of secondary sexual hair (HP:0009888)2.17506401
69Abnormality of the axillary hair (HP:0100134)2.17506401
70Recurrent corneal erosions (HP:0000495)2.17326972
71Ridged nail (HP:0001807)2.13209710
72* Lack of skin elasticity (HP:0100679)2.12102269
73Distal lower limb amyotrophy (HP:0008944)2.05786752
74Difficulty running (HP:0009046)2.05663728
75Urticaria (HP:0001025)2.05223212
76Selective tooth agenesis (HP:0001592)2.05119650
77Muscle fiber splitting (HP:0003555)2.02611248
78Atrophic scars (HP:0001075)2.02409688
79Slow-growing hair (HP:0002217)1.99064408
80Abnormality of hair growth rate (HP:0011363)1.99064408
81Abnormality of the Achilles tendon (HP:0005109)1.98525389
82Increased variability in muscle fiber diameter (HP:0003557)1.98068691
83Muscle hypertrophy of the lower extremities (HP:0008968)1.95413475
84Hypoplastic labia majora (HP:0000059)1.94807151
85Ulnar deviation of the wrist (HP:0003049)1.94564062
86* Dehydration (HP:0001944)1.89855594
87Fatigable weakness (HP:0003473)1.87415050
88Abnormality of the neuromuscular junction (HP:0003398)1.87415050
89Keratoconjunctivitis sicca (HP:0001097)1.86199185
90Abnormality of skeletal muscle fiber size (HP:0012084)1.86078772
91Hyperhidrosis (HP:0000975)1.84914364
92Corneal dystrophy (HP:0001131)1.83059034
93Skin pits (HP:0100276)1.82006867
94Neck muscle weakness (HP:0000467)1.81385178
95Exercise-induced muscle cramps (HP:0003710)1.79982882
96Calf muscle hypertrophy (HP:0008981)1.77202949
97Recurrent bacterial skin infections (HP:0005406)1.76597358
98Anonychia (HP:0001798)1.75442086
99Skin ulcer (HP:0200042)1.74609599
100Pterygium (HP:0001059)1.74434953
101Carious teeth (HP:0000670)1.72890691
102Abnormality of the labia majora (HP:0012881)1.72829651
103Ulnar claw (HP:0001178)1.72275004
104* Dry skin (HP:0000958)1.72161772
105Laryngomalacia (HP:0001601)1.71837960
106Eczematoid dermatitis (HP:0000976)1.70995445
107Hamartoma (HP:0010566)1.69493991
108Brittle hair (HP:0002299)1.68402301
109Abnormality of the gastric mucosa (HP:0004295)1.67479183
110Keratoconjunctivitis (HP:0001096)1.67327813
111Calcaneovalgus deformity (HP:0001848)1.66806457
112Absent phalangeal crease (HP:0006109)1.66749424
113Melanocytic nevus (HP:0000995)1.64198244
114Xerostomia (HP:0000217)1.63749886
115Abnormality of the fingernails (HP:0001231)1.60315701
116Lower limb amyotrophy (HP:0007210)1.58715816
117Fine hair (HP:0002213)1.57886525
118Labial hypoplasia (HP:0000066)1.57547921
119Preauricular skin tag (HP:0000384)1.56752360
120Hypoplastic toenails (HP:0001800)1.56553471
121Duplicated collecting system (HP:0000081)1.56115833
122Aplasia cutis congenita (HP:0001057)1.55460345
123Septate vagina (HP:0001153)1.54904155
124Abnormality of the calf musculature (HP:0001430)1.54877009
125Blepharitis (HP:0000498)1.54852799
126Papilloma (HP:0012740)1.52347462
127Verrucae (HP:0200043)1.52347462
128Split foot (HP:0001839)1.49383503
129Breast hypoplasia (HP:0003187)1.48936791
130Seborrheic dermatitis (HP:0001051)1.46907339
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44428937
132Abnormality of the dental root (HP:0006486)1.43596314
133Taurodontia (HP:0000679)1.43596314
134Abnormality of permanent molar morphology (HP:0011071)1.43596314
135Nasolacrimal duct obstruction (HP:0000579)1.42537071
136Squamous cell carcinoma (HP:0002860)1.40775473
137Generalized hyperpigmentation (HP:0007440)1.38153182
138Skin tags (HP:0010609)1.36823478
139Conical tooth (HP:0000698)1.35228468
140Abnormality of molar (HP:0011077)1.34591866
141Abnormality of molar morphology (HP:0011070)1.34591866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.91695100
2TGFBR14.80914779
3RIPK43.49596354
4FER3.12816789
5SMG13.06878559
6TTN2.98813107
7EPHA42.84158115
8MAP3K122.83077493
9MAP2K42.47887297
10EPHA32.42726971
11MST1R2.41482963
12MAP3K22.40675590
13MAP3K92.38426759
14MAP3K32.20522021
15MST42.19647899
16SGK2232.15313495
17SGK4942.15313495
18NME12.06169619
19CDK122.02909989
20MAP3K111.97458457
21TAOK11.89224432
22NTRK31.87184873
23MAP3K61.86164239
24RPS6KB21.82819765
25PIK3CG1.82589230
26EPHB11.75162066
27GRK61.73933665
28IRAK11.66644822
29TAF11.57299474
30BMPR21.56407057
31FGFR11.48315621
32GRK51.48046501
33RIPK11.47357559
34CDK191.42910560
35MAP3K11.41584975
36CAMK1D1.40717710
37PRPF4B1.40368760
38IRAK31.37993526
39NTRK21.37041908
40KSR21.36673572
41OBSCN1.34629000
42MARK21.30668893
43MINK11.30620053
44MAP3K71.28087402
45IKBKB1.26442267
46ICK1.26280984
47FGFR21.24877805
48MAP2K61.24364587
49BCR1.21691945
50TYRO31.20626926
51MAPKAPK51.20606787
52BLK1.16955600
53MAP2K31.14004172
54MAPK71.09219072
55GRK71.08637602
56ERN11.05155176
57DMPK1.04922455
58MAP3K51.04311407
59DAPK21.01756875
60NLK0.99133845
61LATS20.98826344
62PIM20.98357656
63TRIB30.96964548
64IRAK20.96870832
65CASK0.96651933
66CAMK1G0.95477582
67FGR0.95146053
68WNK10.91741827
69STK240.90855184
70SIK10.89593252
71TESK10.89430812
72PBK0.85208351
73EPHA20.85120763
74EPHB20.83988571
75LATS10.83483369
76MAP2K10.80940672
77PAK60.79683929
78MTOR0.77455899
79MAP3K40.76089907
80MET0.70949388
81PLK20.70433155
82NEK10.68531580
83VRK20.68077084
84PDK30.67585996
85PDK40.67585996
86HIPK20.67460194
87JAK30.66909133
88TRPM70.66688372
89PHKG20.66555164
90PHKG10.66555164
91RPS6KB10.65180545
92EEF2K0.65017933
93PAK30.63744136
94KSR10.62397625
95CDK50.61646745
96CDC42BPA0.60785037
97BMX0.60649207
98LIMK10.60084468
99ERBB30.55600398
100MAPK120.55372869
101PTK2B0.55061705
102STK110.54818276
103ADRBK10.54400435
104GSK3A0.54244970
105RAF10.54221657
106MAPKAPK20.51046409
107AKT30.51028183
108PRKAA20.50611561
109RET0.49573136
110IRAK40.49465601
111CAMK2A0.48978841
112CDK90.48915398
113CDK70.48745365
114CSNK1A1L0.47216940
115CDK30.47025712
116PRKCI0.46689234
117NTRK10.46331508
118MOS0.44945709
119STK100.43916412
120TGFBR20.43496500
121STK380.43478857
122LRRK20.42633662
123ROCK20.42169967
124SGK30.41542127
125PTK20.40653595
126ILK0.40540228
127PDK20.39714501
128MAPK110.38651772
129PTK60.38086132
130MELK0.38036854
131PRKD10.37907274
132FGFR30.37307287
133SYK0.37274187
134PRKD30.36327682
135PRKCE0.35682108
136DYRK1B0.35548306
137SGK10.35469145
138PRKCG0.33116502
139PRKD20.32621046
140PDGFRA0.32267233
141BRD40.30770492
142FGFR40.30622024
143IKBKE0.30522825
144SGK20.29069261
145ABL20.28741502
146MAPK90.25007660
147STK30.24830602
148FLT30.23906002
149MAPK40.23632287
150TAOK30.23524075
151CDK60.22064660
152HCK0.17662164
153MAPK80.17655860
154KIT0.16142524

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.77343507
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.28299790
3Ovarian steroidogenesis_Homo sapiens_hsa049132.51229100
4Salivary secretion_Homo sapiens_hsa049702.47227704
5Sphingolipid metabolism_Homo sapiens_hsa006002.34861006
6Long-term potentiation_Homo sapiens_hsa047202.33965575
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13492140
8Linoleic acid metabolism_Homo sapiens_hsa005912.11682645
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05521032
10Renin secretion_Homo sapiens_hsa049242.00890694
11Fatty acid elongation_Homo sapiens_hsa000621.91750307
12GnRH signaling pathway_Homo sapiens_hsa049121.83984268
13Phenylalanine metabolism_Homo sapiens_hsa003601.76254441
14VEGF signaling pathway_Homo sapiens_hsa043701.74086238
15Long-term depression_Homo sapiens_hsa047301.70493700
16Circadian entrainment_Homo sapiens_hsa047131.69633807
17Olfactory transduction_Homo sapiens_hsa047401.69104090
18Collecting duct acid secretion_Homo sapiens_hsa049661.58599558
19Gastric acid secretion_Homo sapiens_hsa049711.57552055
20Amphetamine addiction_Homo sapiens_hsa050311.54991278
21Glutamatergic synapse_Homo sapiens_hsa047241.53665955
22Synaptic vesicle cycle_Homo sapiens_hsa047211.53141614
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47651178
24Oxytocin signaling pathway_Homo sapiens_hsa049211.46961114
25Nicotine addiction_Homo sapiens_hsa050331.45910740
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44073989
27Calcium signaling pathway_Homo sapiens_hsa040201.43751700
28Ether lipid metabolism_Homo sapiens_hsa005651.38785531
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38262880
30Histidine metabolism_Homo sapiens_hsa003401.35034151
31Phototransduction_Homo sapiens_hsa047441.34200010
32Axon guidance_Homo sapiens_hsa043601.29220969
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.28146222
34Fat digestion and absorption_Homo sapiens_hsa049751.27016683
35Tight junction_Homo sapiens_hsa045301.26010728
36* Serotonergic synapse_Homo sapiens_hsa047261.22096756
37Dopaminergic synapse_Homo sapiens_hsa047281.21215371
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18029428
39Melanogenesis_Homo sapiens_hsa049161.17180785
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16076157
41Alzheimers disease_Homo sapiens_hsa050101.15368206
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15296039
43Acute myeloid leukemia_Homo sapiens_hsa052211.13692764
44* Arachidonic acid metabolism_Homo sapiens_hsa005901.11631213
45Glioma_Homo sapiens_hsa052141.09491600
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07777751
47Pancreatic secretion_Homo sapiens_hsa049721.07741009
48Cardiac muscle contraction_Homo sapiens_hsa042601.06622584
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.05928902
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04422820
51Taste transduction_Homo sapiens_hsa047421.04278220
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99687146
53Oxidative phosphorylation_Homo sapiens_hsa001900.94360780
54Vibrio cholerae infection_Homo sapiens_hsa051100.93099380
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.88737698
56Estrogen signaling pathway_Homo sapiens_hsa049150.86519696
57ErbB signaling pathway_Homo sapiens_hsa040120.85443580
58GABAergic synapse_Homo sapiens_hsa047270.82941632
59Gap junction_Homo sapiens_hsa045400.81977234
60ABC transporters_Homo sapiens_hsa020100.81546423
61Ras signaling pathway_Homo sapiens_hsa040140.78981970
62Adherens junction_Homo sapiens_hsa045200.78499225
63Notch signaling pathway_Homo sapiens_hsa043300.77484307
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77235932
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73635846
66MicroRNAs in cancer_Homo sapiens_hsa052060.73429409
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72387715
68Cholinergic synapse_Homo sapiens_hsa047250.72068637
69Dorso-ventral axis formation_Homo sapiens_hsa043200.72046626
70Dilated cardiomyopathy_Homo sapiens_hsa054140.71318978
71Morphine addiction_Homo sapiens_hsa050320.70771186
72Bladder cancer_Homo sapiens_hsa052190.70504755
73Tyrosine metabolism_Homo sapiens_hsa003500.70272116
74MAPK signaling pathway_Homo sapiens_hsa040100.67463931
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65196900
76Fructose and mannose metabolism_Homo sapiens_hsa000510.62306227
77cAMP signaling pathway_Homo sapiens_hsa040240.62256608
78Insulin secretion_Homo sapiens_hsa049110.62150086
79p53 signaling pathway_Homo sapiens_hsa041150.60388697
80Proteoglycans in cancer_Homo sapiens_hsa052050.58301047
81Glucagon signaling pathway_Homo sapiens_hsa049220.57264756
82Glycerolipid metabolism_Homo sapiens_hsa005610.56348501
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55752050
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.53401449
85ECM-receptor interaction_Homo sapiens_hsa045120.52316752
86Platelet activation_Homo sapiens_hsa046110.51876394
87Rap1 signaling pathway_Homo sapiens_hsa040150.51800043
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.51628094
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50354373
90Arginine biosynthesis_Homo sapiens_hsa002200.50143623
91Thyroid cancer_Homo sapiens_hsa052160.49886882
92Insulin signaling pathway_Homo sapiens_hsa049100.49746684
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48581354
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48156883
95Circadian rhythm_Homo sapiens_hsa047100.47831430
96Pertussis_Homo sapiens_hsa051330.47269479
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46959195
98Pancreatic cancer_Homo sapiens_hsa052120.46787203
99Amoebiasis_Homo sapiens_hsa051460.46068520
100Renal cell carcinoma_Homo sapiens_hsa052110.45797862
101Hippo signaling pathway_Homo sapiens_hsa043900.45252344
102HIF-1 signaling pathway_Homo sapiens_hsa040660.43918793
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43022013
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.42620346
105Wnt signaling pathway_Homo sapiens_hsa043100.42291252
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41503594
107Choline metabolism in cancer_Homo sapiens_hsa052310.41299992
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.40471563
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39361790
110Tuberculosis_Homo sapiens_hsa051520.39352707
111Cocaine addiction_Homo sapiens_hsa050300.39105561
112Inositol phosphate metabolism_Homo sapiens_hsa005620.38387134
113Staphylococcus aureus infection_Homo sapiens_hsa051500.36855181
114Parkinsons disease_Homo sapiens_hsa050120.36218344
115Endocytosis_Homo sapiens_hsa041440.34916212
116Basal cell carcinoma_Homo sapiens_hsa052170.34334882
117Hepatitis C_Homo sapiens_hsa051600.32987224
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32091256
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31966142
120beta-Alanine metabolism_Homo sapiens_hsa004100.29287103
121Influenza A_Homo sapiens_hsa051640.28532987
122Arginine and proline metabolism_Homo sapiens_hsa003300.27836302
123Galactose metabolism_Homo sapiens_hsa000520.24000141
124Chronic myeloid leukemia_Homo sapiens_hsa052200.23723671
125Toxoplasmosis_Homo sapiens_hsa051450.22998318
126Hedgehog signaling pathway_Homo sapiens_hsa043400.22596024
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21724722
128Pathways in cancer_Homo sapiens_hsa052000.20474612
129mTOR signaling pathway_Homo sapiens_hsa041500.18885352
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18833975
131PPAR signaling pathway_Homo sapiens_hsa033200.18695348
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16615095
133Non-small cell lung cancer_Homo sapiens_hsa052230.16613493
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15797300
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14788880
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.12011645
137Mineral absorption_Homo sapiens_hsa049780.11123192
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.09979583
139Small cell lung cancer_Homo sapiens_hsa052220.09691198

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