ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of RNA splicing (GO:0033120)	9.71339002
2	seminiferous tubule development (GO:0072520)	9.59068479
3	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	9.24356419
4	cAMP biosynthetic process (GO:0006171)	8.87023289
5	detection of chemical stimulus involved in sensory perception (GO:0050907)	8.47909798
6	negative regulation of alpha-beta T cell differentiation (GO:0046639)	8.40011211
7	enteric nervous system development (GO:0048484)	7.86478573
8	regulation of protein sumoylation (GO:0033233)	7.55956407
9	synaptic transmission, dopaminergic (GO:0001963)	7.05345226
10	positive regulation of mitochondrial fission (GO:0090141)	7.00335960
11	dendritic spine morphogenesis (GO:0060997)	6.97169599
12	righting reflex (GO:0060013)	6.93752655
13	heterotypic cell-cell adhesion (GO:0034113)	6.54321862
14	positive regulation of T-helper 1 type immune response (GO:0002827)	6.33665912
15	detection of chemical stimulus (GO:0009593)	6.10208596
16	hepatocyte apoptotic process (GO:0097284)	6.04860392
17	arachidonic acid secretion (GO:0050482)	6.03199398
18	icosanoid secretion (GO:0032309)	6.03199398
19	endothelial cell differentiation (GO:0045446)	5.93917540
20	positive regulation of T-helper cell differentiation (GO:0045624)	5.86595503
21	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.47260537
22	drug transmembrane transport (GO:0006855)	5.24928470
23	regulation of mitochondrial fission (GO:0090140)	5.15364812
24	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.10633703
25	neuronal ion channel clustering (GO:0045161)	5.00464416
26	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	5.00316110
27	icosanoid transport (GO:0071715)	4.99856104
28	fatty acid derivative transport (GO:1901571)	4.99856104
29	negative regulation of alpha-beta T cell activation (GO:0046636)	4.88099858
30	chemosensory behavior (GO:0007635)	4.86668189
31	hyaluronan catabolic process (GO:0030214)	4.81943970
32	neural tube formation (GO:0001841)	4.76329668
33	regulation of T-helper 1 type immune response (GO:0002825)	4.57084192
34	cilium or flagellum-dependent cell motility (GO:0001539)	4.49486025
35	embryonic digestive tract morphogenesis (GO:0048557)	4.47833205
36	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	4.47174344
37	cyclic purine nucleotide metabolic process (GO:0052652)	4.44623139
38	nephron tubule morphogenesis (GO:0072078)	4.36754434
39	nephron epithelium morphogenesis (GO:0072088)	4.36754434
40	ATP hydrolysis coupled proton transport (GO:0015991)	4.31554294
41	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	4.31554294
42	vocalization behavior (GO:0071625)	4.30649719
43	cyclic nucleotide biosynthetic process (GO:0009190)	4.29782907
44	retina layer formation (GO:0010842)	4.28847056
45	regulation of T-helper cell differentiation (GO:0045622)	4.26980182
46	attachment of spindle microtubules to kinetochore (GO:0008608)	4.25363345
47	positive regulation of membrane potential (GO:0045838)	4.25223606
48	cellular response to glucagon stimulus (GO:0071377)	4.22556493
49	regulation of cAMP-mediated signaling (GO:0043949)	4.22083988
50	regulation of type 2 immune response (GO:0002828)	4.21044580
51	negative regulation of actin filament bundle assembly (GO:0032232)	4.19619341
52	response to dietary excess (GO:0002021)	4.18089293
53	water transport (GO:0006833)	4.10769124
54	mitochondrial fusion (GO:0008053)	4.06401577
55	dendritic spine organization (GO:0097061)	3.99030188
56	cAMP metabolic process (GO:0046058)	3.98751475
57	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	3.93514848
58	protein localization to synapse (GO:0035418)	3.92613560
59	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.88964593
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.82602073
61	cellular zinc ion homeostasis (GO:0006882)	3.76952613
62	monoamine transport (GO:0015844)	3.73648015
63	negative regulation of T cell differentiation (GO:0045581)	3.71304677
64	fluid transport (GO:0042044)	3.66773692
65	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.60980370
66	leukotriene biosynthetic process (GO:0019370)	3.60008850
67	drug transport (GO:0015893)	3.59298519
68	positive regulation of protein targeting to membrane (GO:0090314)	3.55814854
69	pre-miRNA processing (GO:0031054)	3.53759401
70	cellular response to ATP (GO:0071318)	3.51977706
71	sulfur amino acid catabolic process (GO:0000098)	3.49729180
72	sequestering of metal ion (GO:0051238)	3.46561023
73	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.45012674
74	positive regulation of alpha-beta T cell differentiation (GO:0046638)	3.38653187
75	regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	3.36464065
76	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.35501540
77	left/right axis specification (GO:0070986)	3.35086774
78	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.20005694
79	response to glucagon (GO:0033762)	3.15542042
80	neuromuscular process controlling posture (GO:0050884)	3.15020414
81	renal tubule morphogenesis (GO:0061333)	3.14044985
82	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.12424712
83	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.11511767
84	neurofilament cytoskeleton organization (GO:0060052)	3.10767798
85	negative regulation of astrocyte differentiation (GO:0048712)	3.09427449
86	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.08387201
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.08320622
88	positive regulation of steroid hormone secretion (GO:2000833)	3.07261909
89	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)	3.06005094
90	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	3.05782299
91	tooth mineralization (GO:0034505)	14.3710079
92	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	13.6446219
93	positive regulation of protein sumoylation (GO:0033235)	12.0076975
94	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	11.4859230
95	negative regulation of T-helper cell differentiation (GO:0045623)	11.4859230
96	protein K11-linked deubiquitination (GO:0035871)	10.6325650
97	regulation of T-helper 1 cell differentiation (GO:0045625)	10.3552094
98	regulation of T-helper 2 cell differentiation (GO:0045628)	10.2359187
99	negative regulation of type 2 immune response (GO:0002829)	10.1579196
100	activation of protein kinase A activity (GO:0034199)	10.1322482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.58312102
2	EGR1_19374776_ChIP-ChIP_THP-1_Human	5.72933633
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.79018661
4	AR_21572438_ChIP-Seq_LNCaP_Human	4.74397014
5	VDR_22108803_ChIP-Seq_LS180_Human	4.18794034
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.54013155
7	TP53_16413492_ChIP-PET_HCT116_Human	2.14760835
8	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.01993147
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	10.7734489
10	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.95436466
11	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.89089827
12	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.86200776
13	GATA1_19941826_ChIP-Seq_K562_Human	1.85541560
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85509751
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85509751
16	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.65813392
17	DROSHA_22980978_ChIP-Seq_HELA_Human	1.61198580
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58274290
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.57973514
20	EGR1_19032775_ChIP-ChIP_M12_Human	1.54818038
21	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.54591833
22	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.48452530
23	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.48238130
24	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.44706664
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42457399
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41303109
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35355386
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34486778
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32139931
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31006968
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30992906
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24591961
33	RXR_22108803_ChIP-Seq_LS180_Human	1.23465227
34	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23100905
35	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21499748
36	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.17741667
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16129239
38	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14783673
39	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11576482
40	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.10681108
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10386589
42	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.09404547
43	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.08841934
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06737749
45	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06024527
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05109037
47	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.03072226
48	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.02682458
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.01583561
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01399909
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01033703
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00807535
53	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.00246789
54	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99625639
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99601103
56	EZH2_22144423_ChIP-Seq_EOC_Human	0.99181919
57	GBX2_23144817_ChIP-Seq_PC3_Human	0.99105761
58	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.98839962
59	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98721316
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98204227
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96872628
62	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96790568
63	TBL1_22424771_ChIP-Seq_293T_Human	0.95442226
64	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95370989
65	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95293107
66	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.94017546
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93402027
68	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.93383454
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90738076
70	CJUN_26792858_Chip-Seq_BT549_Human	0.90565285
71	PHF8_20622853_ChIP-Seq_HELA_Human	0.90218713
72	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.89493281
73	STAT3_23295773_ChIP-Seq_U87_Human	0.88716090
74	CTCF_27219007_Chip-Seq_Bcells_Human	0.86767779
75	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.86734156
76	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.86312241
77	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.86074561
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85026699
79	BCAT_22108803_ChIP-Seq_LS180_Human	0.84784590
80	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.83753635
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.83639048
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.81919475
83	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.81347841
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81109906
85	GATA2_19941826_ChIP-Seq_K562_Human	0.80780861
86	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.80220183
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.80142615
88	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.80132334
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.80132334
90	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.80117221
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.79929020
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.76921569
93	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.76313619
94	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.74720642
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.74630496
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.74398949
97	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.73985472
98	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.73793274
99	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.73323224
100	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.72230569

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008961_abnormal_basal_metabolism	9.75048557
2	MP0004130_abnormal_muscle_cell	5.02739754
3	MP0004264_abnormal_extraembryonic_tissu	4.01381212
4	MP0003252_abnormal_bile_duct	3.62269000
5	MP0004133_heterotaxia	2.80588646
6	MP0002928_abnormal_bile_duct	2.72548107
7	MP0006072_abnormal_retinal_apoptosis	2.40088996
8	MP0005448_abnormal_energy_balance	2.31420286
9	MP0005408_hypopigmentation	2.22749849
10	MP0002751_abnormal_autonomic_nervous	2.21562489
11	MP0003329_amyloid_beta_deposits	2.14710068
12	MP0004272_abnormal_basement_membrane	2.13832129
13	MP0001270_distended_abdomen	2.12386018
14	MP0005084_abnormal_gallbladder_morpholo	12.7257620
15	MP0003943_abnormal_hepatobiliary_system	1.77385843
16	MP0005220_abnormal_exocrine_pancreas	1.65590093
17	MP0005379_endocrine/exocrine_gland_phen	1.59053916
18	MP0005165_increased_susceptibility_to	1.58492435
19	MP0009764_decreased_sensitivity_to	1.45535869
20	MP0001958_emphysema	1.43746720
21	MP0000604_amyloidosis	1.37726392
22	MP0001529_abnormal_vocalization	1.28516220
23	MP0003718_maternal_effect	1.24340657
24	MP0005646_abnormal_pituitary_gland	1.09421821
25	MP0000465_gastrointestinal_hemorrhage	1.06990464
26	MP0000470_abnormal_stomach_morphology	1.02292881
27	MP0002909_abnormal_adrenal_gland	1.00526954
28	MP0001905_abnormal_dopamine_level	0.99884384
29	MP0001944_abnormal_pancreas_morphology	0.98759538
30	MP0002572_abnormal_emotion/affect_behav	0.95263530
31	MP0008569_lethality_at_weaning	0.93140443
32	MP0003638_abnormal_response/metabolism_	0.91760507
33	MP0001915_intracranial_hemorrhage	0.81654209
34	MP0005164_abnormal_response_to	0.81127824
35	MP0008469_abnormal_protein_level	0.80502271
36	MP0003121_genomic_imprinting	0.78818551
37	MP0001800_abnormal_humoral_immune	0.78246360
38	MP0000371_diluted_coat_color	0.77194737
39	MP0002405_respiratory_system_inflammati	0.76940699
40	MP0004019_abnormal_vitamin_homeostasis	0.74313139
41	MP0000609_abnormal_liver_physiology	0.73407088
42	MP0002693_abnormal_pancreas_physiology	0.72058274
43	MP0003866_abnormal_defecation	0.72046261
44	MP0000703_abnormal_thymus_morphology	0.67591427
45	MP0002098_abnormal_vibrissa_morphology	0.67494330
46	MP0008875_abnormal_xenobiotic_pharmacok	0.67154741
47	MP0001851_eye_inflammation	0.64949845
48	MP0004947_skin_inflammation	0.64664431
49	MP0001790_abnormal_immune_system	0.63823991
50	MP0005387_immune_system_phenotype	0.63823991
51	MP0002136_abnormal_kidney_physiology	0.63390220
52	MP0001533_abnormal_skeleton_physiology	0.63387229
53	MP0002078_abnormal_glucose_homeostasis	0.62910249
54	MP0005253_abnormal_eye_physiology	0.62746050
55	MP0003953_abnormal_hormone_level	0.60825094
56	MP0002998_abnormal_bone_remodeling	0.58477250
57	MP0001845_abnormal_inflammatory_respons	0.52032948
58	MP0002722_abnormal_immune_system	0.48499635
59	MP0009642_abnormal_blood_homeostasis	0.47620103
60	MP0002419_abnormal_innate_immunity	0.40673291
61	MP0005334_abnormal_fat_pad	0.39580556
62	MP0002429_abnormal_blood_cell	0.39301789
63	MP0000759_abnormal_skeletal_muscle	0.38633429
64	MP0003195_calcinosis	0.38329240
65	MP0005551_abnormal_eye_electrophysiolog	0.37708057
66	MP0000920_abnormal_myelination	0.37249010
67	MP0000598_abnormal_liver_morphology	0.37209398
68	MP0000477_abnormal_intestine_morphology	0.37041905
69	MP0008004_abnormal_stomach_pH	0.36602652
70	MP0002452_abnormal_antigen_presenting	0.36590031
71	MP0002822_catalepsy	0.36425813
72	MP0004484_altered_response_of	0.36289593
73	MP0009931_abnormal_skin_appearance	0.36287025
74	MP0005365_abnormal_bile_salt	0.35807972
75	MP0005423_abnormal_somatic_nervous	0.33985140
76	MP0001986_abnormal_taste_sensitivity	0.33669950
77	MP0002420_abnormal_adaptive_immunity	0.32946076
78	MP0000716_abnormal_immune_system	0.32759792
79	MP0001835_abnormal_antigen_presentation	0.32698074
80	MP0005390_skeleton_phenotype	0.32471997
81	MP0002882_abnormal_neuron_morphology	0.32330217
82	MP0001819_abnormal_immune_cell	0.32306859
83	MP0002398_abnormal_bone_marrow	0.31916569
84	MP0001299_abnormal_eye_distance/	0.31148303
85	MP0001501_abnormal_sleep_pattern	0.30814211
86	MP0002229_neurodegeneration	0.30170676
87	MP0002723_abnormal_immune_serum	0.30032944
88	MP0001175_abnormal_lung_morphology	0.27853443
89	MP0005395_other_phenotype	0.27778620
90	MP0005000_abnormal_immune_tolerance	0.27591507
91	MP0002735_abnormal_chemical_nociception	0.26754561
92	MP0000689_abnormal_spleen_morphology	0.25987306
93	MP0002396_abnormal_hematopoietic_system	0.24267949
94	MP0009053_abnormal_anal_canal	0.23429005
95	MP0002128_abnormal_blood_circulation	0.22404941
96	MP0002066_abnormal_motor_capabilities/c	0.22022974
97	MP0000249_abnormal_blood_vessel	0.21075266
98	MP0003634_abnormal_glial_cell	0.20244391
99	MP0002113_abnormal_skeleton_development	0.19805027
100	MP0002161_abnormal_fertility/fecundity	0.19279732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of dental color (HP:0011073)	8.32352639
2	Abnormality of renal resorption (HP:0011038)	8.15737072
3	Osteomalacia (HP:0002749)	7.92292348
4	Polyuria (HP:0000103)	7.63816606
5	Abnormality of the dental pulp (HP:0006479)	7.57264553
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.78971127
7	Abnormal urine output (HP:0012590)	6.54396783
8	Abnormality of renal excretion (HP:0011036)	5.70901841
9	Round ear (HP:0100830)	5.51956104
10	Chronic bronchitis (HP:0004469)	4.93564920
11	Volvulus (HP:0002580)	4.33991057
12	IgM deficiency (HP:0002850)	4.24933236
13	Lip pit (HP:0100267)	4.23215720
14	Autoimmune thrombocytopenia (HP:0001973)	4.09438519
15	Toxemia of pregnancy (HP:0100603)	3.98750666
16	Nephrocalcinosis (HP:0000121)	3.89855763
17	Esophageal varix (HP:0002040)	3.86883811
18	Abnormality of midbrain morphology (HP:0002418)	3.77850804
19	Molar tooth sign on MRI (HP:0002419)	3.77850804
20	Lipoatrophy (HP:0100578)	3.44900826
21	Sparse lateral eyebrow (HP:0005338)	3.38124871
22	Depressed nasal tip (HP:0000437)	3.34721688
23	Large earlobe (HP:0009748)	3.32407002
24	Abnormal respiratory motile cilium physiology (HP:0012261)	3.29594517
25	Rhinitis (HP:0012384)	3.25747503
26	Tachypnea (HP:0002789)	3.21596203
27	Drooling (HP:0002307)	3.18054123
28	Hypoparathyroidism (HP:0000829)	3.15875808
29	Intestinal fistula (HP:0100819)	3.15466175
30	Excessive salivation (HP:0003781)	3.05502045
31	Panhypogammaglobulinemia (HP:0003139)	3.03457753
32	Hyperphosphaturia (HP:0003109)	2.88668688
33	Personality changes (HP:0000751)	2.87400701
34	Thick eyebrow (HP:0000574)	2.86645445
35	Petechiae (HP:0000967)	2.82475839
36	Nephronophthisis (HP:0000090)	2.62275284
37	Hepatitis (HP:0012115)	2.57538928
38	Dilated cardiomyopathy (HP:0001644)	2.57188907
39	Ureteral stenosis (HP:0000071)	2.56040840
40	Abnormality of the fingertips (HP:0001211)	2.50975867
41	Abnormal urine phosphate concentration (HP:0012599)	2.44981566
42	Short 5th finger (HP:0009237)	2.44253958
43	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.38682750
44	Recurrent cutaneous fungal infections (HP:0011370)	2.38485636
45	Chronic mucocutaneous candidiasis (HP:0002728)	2.38485636
46	Abnormality of transition element cation homeostasis (HP:0011030)	2.37443968
47	Ureteral obstruction (HP:0006000)	2.36098517
48	Glycosuria (HP:0003076)	2.33938196
49	Abnormality of urine glucose concentration (HP:0011016)	2.33938196
50	Striae distensae (HP:0001065)	2.33695994
51	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.32954644
52	Sudden cardiac death (HP:0001645)	2.31299670
53	Gingival overgrowth (HP:0000212)	2.30972267
54	Colitis (HP:0002583)	2.28743417
55	Nephropathy (HP:0000112)	2.25153666
56	Hypercalciuria (HP:0002150)	2.22438567
57	Preauricular pit (HP:0004467)	2.15552558
58	Periauricular skin pits (HP:0100277)	2.15552558
59	Bronchitis (HP:0012387)	2.11529345
60	Recurrent otitis media (HP:0000403)	2.10403253
61	Decreased muscle mass (HP:0003199)	2.10160983
62	Inability to walk (HP:0002540)	2.09096009
63	Agammaglobulinemia (HP:0004432)	2.08606657
64	Anal stenosis (HP:0002025)	2.03139708
65	Abnormality of salivation (HP:0100755)	2.01757306
66	Delayed eruption of teeth (HP:0000684)	2.00396264
67	Overgrowth (HP:0001548)	12.3624849
68	Amelogenesis imperfecta (HP:0000705)	11.7384397
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	10.1516068
70	Chondrocalcinosis (HP:0000934)	1.98905715
71	Abnormality of the renal medulla (HP:0100957)	1.95785628
72	Abnormality of Sharpey fibers (HP:0100685)	1.94484169
73	Ectopic kidney (HP:0000086)	1.87213912
74	Chorioretinal coloboma (HP:0000567)	1.87013149
75	Preauricular skin tag (HP:0000384)	1.83273220
76	Truncal ataxia (HP:0002078)	1.82736176
77	Renal tubular dysfunction (HP:0000124)	1.80424122
78	Prominent supraorbital ridges (HP:0000336)	1.78679532
79	Stage 5 chronic kidney disease (HP:0003774)	1.75651269
80	Limited elbow extension (HP:0001377)	1.74636138
81	Abnormality of small intestinal villus morphology (HP:0011472)	1.69898375
82	Villous atrophy (HP:0011473)	1.69898375
83	Torticollis (HP:0000473)	1.62347072
84	Oculomotor apraxia (HP:0000657)	1.59040421
85	Ectropion (HP:0000656)	1.58943458
86	Small hand (HP:0200055)	1.58482910
87	Palmoplantar keratoderma (HP:0000982)	1.58213124
88	Polyneuropathy (HP:0001271)	1.56547354
89	Blepharitis (HP:0000498)	1.53957099
90	Skin tags (HP:0010609)	1.53840149
91	Bronchiectasis (HP:0002110)	1.49411741
92	Viral hepatitis (HP:0006562)	1.48959760
93	Prenatal maternal abnormality (HP:0002686)	1.48368683
94	Skin pits (HP:0100276)	1.45551182
95	Mask-like facies (HP:0000298)	1.44448762
96	Inflammation of the large intestine (HP:0002037)	1.43470182
97	Osteoarthritis (HP:0002758)	1.40218559
98	Proximal placement of thumb (HP:0009623)	1.40042215
99	Highly arched eyebrow (HP:0002553)	1.39179485
100	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.30948966

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	5.67888569
2	BLK	4.39259583
3	STK3	4.12206563
4	RIPK4	3.25972674
5	CDC42BPA	2.19561378
6	BMPR2	2.11423923
7	NTRK2	14.2232725
8	HIPK2	1.26428962
9	FGFR1	0.91461609
10	ROCK2	0.79814573
11	SYK	0.69646427
12	SRC	0.64120891
13	OBSCN	0.59413142
14	PRKCQ	0.58964625
15	INSRR	0.58778910
16	PRKAA1	0.58079434
17	ROCK1	0.55796671
18	MUSK	0.55311085
19	MAP4K2	0.48046047
20	GRK7	0.45266562
21	PRKACG	0.44505454
22	MAPK15	0.42546112
23	ABL1	0.42095457
24	TXK	0.41706799
25	TIE1	0.39451799
26	WNK3	0.39353376
27	ADRBK2	0.38818537
28	GRK1	0.38273514
29	PRKACA	0.35812443
30	PRKACB	0.35433802
31	SRPK1	0.32739825
32	CAMK2A	0.31495110
33	PIK3CG	0.30585543
34	ERBB4	0.29780862
35	LYN	0.26179949
36	MATK	0.24883639
37	PLK1	0.24403650
38	PLK4	0.22835600
39	PRKCA	0.22475990
40	MAPK14	0.22218177
41	MST1R	0.21708671
42	DDR2	0.21660795
43	GSK3B	0.21509912
44	TTN	0.21053822
45	EPHA4	0.20972927
46	PRKCB	0.20163659
47	LMTK2	0.19859924
48	TEC	0.19579239
49	RPS6KA3	0.19550566
50	KIT	0.18049004
51	FYN	0.17829036
52	GRK5	0.17373639
53	TLK1	0.16312751
54	PHKG1	0.15688693
55	PHKG2	0.15688693
56	EPHA2	0.15619870
57	KDR	0.15415968
58	GRK6	0.15223433
59	ITK	0.14480032
60	CDK1	0.14119412
61	PRKCD	0.13892374
62	PIM2	0.13787316
63	CSNK1A1	0.13218139
64	WNK4	0.13033581
65	CHUK	0.12796699
66	BTK	0.11218430
67	PINK1	0.10740059
68	MAP2K6	0.10723560
69	MAPK9	0.10376319
70	OXSR1	0.09878950
71	HCK	0.09796423
72	PRKDC	0.09705200
73	LCK	0.09320170
74	TNK2	0.09304813
75	PKN1	0.08387773
76	ADRBK1	0.08114918
77	PRKCG	0.07657924
78	CAMK2G	0.07416724
79	EGFR	0.06978904
80	IGF1R	0.06843695
81	TAOK2	0.06518742
82	AKT1	0.06370225
83	ABL2	0.06313027
84	TGFBR2	0.05692516
85	MYLK	0.05674728
86	PIM1	0.05034264
87	IKBKE	0.04166787
88	INSR	0.03865532
89	STK39	0.03713111
90	PRKG2	0.03667418
91	PRKCE	0.03554962
92	NTRK1	0.03525791
93	MAP3K4	0.02500086
94	PRKG1	0.02246517
95	FLT3	0.01900433
96	PIK3CA	0.01559791
97	MAPK4	0.01524777
98	ZAK	0.01443928
99	MOS	0.01336962
100	DAPK3	0.01228935

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	5.26404244
2	Sulfur relay system_Homo sapiens_hsa04122	3.76775619
3	Sulfur metabolism_Homo sapiens_hsa00920	3.69239769
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.35054396
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.14800040
6	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	2.90229901
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.87575986
8	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.75052985
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.50831850
10	Vibrio cholerae infection_Homo sapiens_hsa05110	2.40235427
11	Bile secretion_Homo sapiens_hsa04976	2.38087045
12	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.23075560
13	Pancreatic secretion_Homo sapiens_hsa04972	2.21768067
14	Salivary secretion_Homo sapiens_hsa04970	2.13228361
15	Fat digestion and absorption_Homo sapiens_hsa04975	2.11273414
16	Gastric acid secretion_Homo sapiens_hsa04971	2.10046326
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.05061762
18	Cocaine addiction_Homo sapiens_hsa05030	1.93584141
19	Circadian entrainment_Homo sapiens_hsa04713	1.84625940
20	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.82605977
21	Insulin secretion_Homo sapiens_hsa04911	1.78474409
22	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.76291828
23	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.76131217
24	Taste transduction_Homo sapiens_hsa04742	1.71518234
25	Glutamatergic synapse_Homo sapiens_hsa04724	1.71250799
26	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.67345715
27	GABAergic synapse_Homo sapiens_hsa04727	1.67238240
28	Morphine addiction_Homo sapiens_hsa05032	1.66921833
29	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.65298533
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.58314970
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.58294780
32	Gap junction_Homo sapiens_hsa04540	1.57095292
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.44473142
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43333481
35	Amphetamine addiction_Homo sapiens_hsa05031	1.39605303
36	GnRH signaling pathway_Homo sapiens_hsa04912	1.39476794
37	Melanogenesis_Homo sapiens_hsa04916	1.33609543
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.30642709
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.28058324
40	Platelet activation_Homo sapiens_hsa04611	1.20364141
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.17636148
42	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.15266938
43	Cholinergic synapse_Homo sapiens_hsa04725	1.14188732
44	Estrogen signaling pathway_Homo sapiens_hsa04915	1.08711820
45	Calcium signaling pathway_Homo sapiens_hsa04020	1.05683368
46	Circadian rhythm_Homo sapiens_hsa04710	0.99456003
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.90347223
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.81314947
49	Serotonergic synapse_Homo sapiens_hsa04726	0.76276456
50	ECM-receptor interaction_Homo sapiens_hsa04512	0.74769495
51	Oocyte meiosis_Homo sapiens_hsa04114	0.74014870
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.73579460
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67855761
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.64355353
55	RNA degradation_Homo sapiens_hsa03018	0.52874198
56	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47225032
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.45714906
58	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.43153389
59	Alcoholism_Homo sapiens_hsa05034	0.41964877
60	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39621309
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34685258
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34645168
63	Primary immunodeficiency_Homo sapiens_hsa05340	0.33994354
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.33490714
65	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32773742
66	Prion diseases_Homo sapiens_hsa05020	0.29722964
67	Parkinsons disease_Homo sapiens_hsa05012	0.29217642
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28143446
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.24103903
70	Purine metabolism_Homo sapiens_hsa00230	0.23412138
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.22438830
72	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20704245
73	Retinol metabolism_Homo sapiens_hsa00830	0.18838455
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.17795574
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15949390
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15442613
77	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15110373
78	Phagosome_Homo sapiens_hsa04145	0.15106875
79	Tuberculosis_Homo sapiens_hsa05152	0.14903553
80	Ras signaling pathway_Homo sapiens_hsa04014	0.11598293
81	HTLV-I infection_Homo sapiens_hsa05166	0.11275389
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.11211724
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.11102654
84	African trypanosomiasis_Homo sapiens_hsa05143	0.10102528
85	Leishmaniasis_Homo sapiens_hsa05140	0.09546085
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.09376562
87	Caffeine metabolism_Homo sapiens_hsa00232	0.09202139
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.07150408
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.07126855
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.06311987
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.05768255
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.05351446
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.04606922
94	Renin secretion_Homo sapiens_hsa04924	0.04558909
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.04106429
96	Amoebiasis_Homo sapiens_hsa05146	0.01714958
97	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.01498745
98	Autoimmune thyroid disease_Homo sapiens_hsa05320	-0.0276945
99	Nicotine addiction_Homo sapiens_hsa05033	-0.0125785
100	Asthma_Homo sapiens_hsa05310	-0.0001890

ALOX12P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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