ALOX15B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.67392000
2desmosome organization (GO:0002934)8.06045812
3regulation of water loss via skin (GO:0033561)7.82904115
4keratinization (GO:0031424)7.43482236
5hemidesmosome assembly (GO:0031581)7.24575000
6intermediate filament organization (GO:0045109)6.97147894
7keratinocyte proliferation (GO:0043616)5.87059020
8surfactant homeostasis (GO:0043129)5.83338894
9peptide cross-linking (GO:0018149)5.69838390
10chemical homeostasis within a tissue (GO:0048875)5.42182060
11multicellular organismal water homeostasis (GO:0050891)5.39212342
12fatty acid elongation (GO:0030497)5.21927390
13water homeostasis (GO:0030104)4.79266623
14intermediate filament cytoskeleton organization (GO:0045104)4.45177239
15* linoleic acid metabolic process (GO:0043651)4.39621284
16keratinocyte differentiation (GO:0030216)4.38453682
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.29794561
18intermediate filament-based process (GO:0045103)4.29564707
19epidermis development (GO:0008544)4.16978953
20endothelial cell chemotaxis (GO:0035767)3.85755175
21hair follicle morphogenesis (GO:0031069)3.81770389
22iron ion import (GO:0097286)3.71413246
23retinol metabolic process (GO:0042572)3.70329655
24skin morphogenesis (GO:0043589)3.60043703
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47366855
26epidermal cell differentiation (GO:0009913)3.43077914
27cell-substrate junction assembly (GO:0007044)3.37539337
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.35739226
29regulation of memory T cell differentiation (GO:0043380)3.35222711
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.16244644
31intestinal epithelial cell development (GO:0060576)3.04803790
32import into cell (GO:0098657)3.01448224
33toxin transport (GO:1901998)2.99751565
34adhesion of symbiont to host cell (GO:0044650)2.99086030
35virion attachment to host cell (GO:0019062)2.99086030
36T-helper 1 type immune response (GO:0042088)2.98404481
37sexual reproduction (GO:0019953)2.90615470
38primary alcohol metabolic process (GO:0034308)2.88252910
39primary alcohol catabolic process (GO:0034310)2.84722195
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.78444278
41fatty-acyl-CoA biosynthetic process (GO:0046949)2.77645673
42retinal metabolic process (GO:0042574)2.71207750
43negative regulation of keratinocyte proliferation (GO:0010839)2.70318404
44* lipoxygenase pathway (GO:0019372)2.70021662
45alpha-linolenic acid metabolic process (GO:0036109)2.64938043
46adhesion of symbiont to host (GO:0044406)2.61924847
47positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.60924744
48phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60666546
49phospholipid scrambling (GO:0017121)2.56175183
50phosphatidylserine acyl-chain remodeling (GO:0036150)2.51837942
51negative regulation of fatty acid transport (GO:2000192)2.50614229
52plasma membrane repair (GO:0001778)2.46542366
53protein autoprocessing (GO:0016540)2.45402985
54very long-chain fatty acid metabolic process (GO:0000038)2.41714381
55adaptation of signaling pathway (GO:0023058)2.41442820
56positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41176509
57positive regulation of T-helper cell differentiation (GO:0045624)2.39824929
58regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.39761213
59acyl-CoA biosynthetic process (GO:0071616)2.37607224
60thioester biosynthetic process (GO:0035384)2.37607224
61molting cycle process (GO:0022404)2.33687973
62hair cycle process (GO:0022405)2.33687973
63regulation of phospholipase A2 activity (GO:0032429)2.33685568
64fatty-acyl-CoA metabolic process (GO:0035337)2.33393869
65polarized epithelial cell differentiation (GO:0030859)2.30575380
66extracellular matrix assembly (GO:0085029)2.28339049
67regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.28288792
68prostate gland epithelium morphogenesis (GO:0060740)2.27217773
69negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.26849151
70branching involved in prostate gland morphogenesis (GO:0060442)2.26491700
71regulation of cytokine production involved in inflammatory response (GO:1900015)2.26428703
72renal filtration (GO:0097205)2.26170551
73cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.24782663
74negative regulation of complement activation (GO:0045916)2.22240057
75mannose metabolic process (GO:0006013)2.21234864
76negative regulation of interleukin-2 production (GO:0032703)2.18996009
77one-carbon compound transport (GO:0019755)2.17133136
78regulation of activation of Janus kinase activity (GO:0010533)2.17068918
79extracellular matrix disassembly (GO:0022617)2.15396294
80negative regulation of smooth muscle cell proliferation (GO:0048662)2.14948686
81epithelial cell-cell adhesion (GO:0090136)2.12527949
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11520889
83regulation of tight junction assembly (GO:2000810)2.11496167
84regulation of receptor binding (GO:1900120)2.11184115
85face development (GO:0060324)2.09843972
86carnitine metabolic process (GO:0009437)2.09440452
87interleukin-1-mediated signaling pathway (GO:0070498)2.09076821
88phosphatidylcholine acyl-chain remodeling (GO:0036151)2.08860162
89ethanol metabolic process (GO:0006067)2.08575723
90phosphatidylserine metabolic process (GO:0006658)2.07886060
91negative regulation of stress fiber assembly (GO:0051497)2.07726281
92detection of bacterium (GO:0016045)2.06858759
93cellular response to zinc ion (GO:0071294)2.06426368
94epithelium development (GO:0060429)2.05785438
95phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.05226457
96protein localization to endosome (GO:0036010)2.05051648
97retina homeostasis (GO:0001895)2.04982078
98semaphorin-plexin signaling pathway (GO:0071526)2.04745901
99hair cycle (GO:0042633)10.0514215
100molting cycle (GO:0042303)10.0514215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.74381771
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.01702546
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91965717
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.90236915
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.48196505
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.44159852
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.23336388
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.04007980
9ESR1_20079471_ChIP-ChIP_T-47D_Human1.97186034
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94612336
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91388339
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85175679
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81612501
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74995474
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74995474
16RACK7_27058665_Chip-Seq_MCF-7_Human1.73014233
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72138058
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71312869
19* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65608404
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62447357
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.60124192
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.56630905
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55886487
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.55157035
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.48833940
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43088175
27ZNF263_19887448_ChIP-Seq_K562_Human1.43032412
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41787782
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39367715
30* TP63_22573176_ChIP-Seq_HFKS_Human1.38534320
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.38178256
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38134812
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.36366681
34LXR_22292898_ChIP-Seq_THP-1_Human1.34498405
35CLOCK_20551151_ChIP-Seq_293T_Human1.31759875
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.30487454
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29844722
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28298764
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.28062945
40* TP63_23658742_ChIP-Seq_EP156T_Human1.27104749
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26696261
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25942862
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24461572
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23655803
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23547646
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22460832
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.19447306
48AHR_22903824_ChIP-Seq_MCF-7_Human1.19223188
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17743066
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.16920190
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16609045
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.16069338
53SOX2_20726797_ChIP-Seq_SW620_Human1.15224321
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14582629
55KLF5_25053715_ChIP-Seq_YYC3_Human1.13640036
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11859209
57EGR1_19032775_ChIP-ChIP_M12_Human1.11392888
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10611585
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09503206
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.09298898
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.07400656
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.07400656
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07359586
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04640900
65CREB1_26743006_Chip-Seq_LNCaP_Human1.03641895
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03610261
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01555759
68GATA4_25053715_ChIP-Seq_YYC3_Human1.01530866
69AR_21572438_ChIP-Seq_LNCaP_Human1.00602658
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99716237
71TCF4_18268006_ChIP-ChIP_LS174T_Human0.99044832
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98241152
73SA1_27219007_Chip-Seq_ERYTHROID_Human0.96507735
74CJUN_26792858_Chip-Seq_BT549_Human0.96175676
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93756239
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93669001
77ATF3_27146783_Chip-Seq_COLON_Human0.92637733
78GATA6_25053715_ChIP-Seq_YYC3_Human0.91918058
79KDM2B_26808549_Chip-Seq_K562_Human0.91669872
80P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90991182
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90535211
82GATA1_19941826_ChIP-Seq_K562_Human0.89681483
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89160774
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88897855
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88807428
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88007897
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87719672
88VDR_24787735_ChIP-Seq_THP-1_Human0.86839156
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.86702368
90BCOR_27268052_Chip-Seq_Bcells_Human0.85937991
91* SMC4_20622854_ChIP-Seq_HELA_Human0.85729445
92TCF7_22412390_ChIP-Seq_EML_Mouse0.84856708
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82800664
94RXR_22108803_ChIP-Seq_LS180_Human0.82737768
95CTCF_27219007_Chip-Seq_Bcells_Human0.82297767
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81877516
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81601837
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.80545484
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.77913324
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76404143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.11860843
2MP0002796_impaired_skin_barrier5.65148550
3MP0010234_abnormal_vibrissa_follicle4.34531320
4MP0000579_abnormal_nail_morphology3.97893861
5MP0002098_abnormal_vibrissa_morphology3.51230782
6MP0004381_abnormal_hair_follicle3.41008522
7MP0009379_abnormal_foot_pigmentation3.26541565
8MP0004947_skin_inflammation3.19842776
9MP0000647_abnormal_sebaceous_gland2.99965013
10MP0005501_abnormal_skin_physiology2.95730013
11MP0003011_delayed_dark_adaptation2.81228146
12MP0003705_abnormal_hypodermis_morpholog2.80273389
13MP0003453_abnormal_keratinocyte_physiol2.74426525
14MP0001216_abnormal_epidermal_layer2.69679230
15MP0002060_abnormal_skin_morphology2.55440780
16MP0010678_abnormal_skin_adnexa2.48199417
17MP0000383_abnormal_hair_follicle2.41592282
18MP0000377_abnormal_hair_follicle2.37599701
19MP0010771_integument_phenotype2.11533254
20MP0001958_emphysema2.10473108
21MP0004782_abnormal_surfactant_physiolog2.10428247
22MP0003566_abnormal_cell_adhesion1.95864875
23MP0005409_darkened_coat_color1.80781630
24MP0001188_hyperpigmentation1.77755392
25MP0000566_synostosis1.64366258
26MP0000467_abnormal_esophagus_morphology1.63513521
27MP0003191_abnormal_cellular_cholesterol1.60434990
28MP0009931_abnormal_skin_appearance1.60221783
29MP0004510_myositis1.51313175
30MP0003300_gastrointestinal_ulcer1.50512801
31MP0000367_abnormal_coat/_hair1.49363032
32MP0003941_abnormal_skin_development1.47301810
33MP0004043_abnormal_pH_regulation1.39706266
34MP0002234_abnormal_pharynx_morphology1.31857927
35MP0003045_fibrosis1.29482394
36MP0001851_eye_inflammation1.26101979
37MP0005023_abnormal_wound_healing1.25071777
38MP0002166_altered_tumor_susceptibility1.21490369
39MP0000762_abnormal_tongue_morphology1.19026667
40MP0005647_abnormal_sex_gland1.16402077
41MP0005310_abnormal_salivary_gland1.15016872
42MP0002095_abnormal_skin_pigmentation1.11989852
43MP0002148_abnormal_hypersensitivity_rea1.11013689
44MP0000685_abnormal_immune_system1.04560797
45MP0009840_abnormal_foam_cell1.01954369
46MP0004264_abnormal_extraembryonic_tissu1.01242380
47MP0001243_abnormal_dermal_layer0.97303098
48MP0004858_abnormal_nervous_system0.96397141
49MP0003724_increased_susceptibility_to0.96021770
50MP0004019_abnormal_vitamin_homeostasis0.95924127
51MP0005670_abnormal_white_adipose0.94172277
52MP0001191_abnormal_skin_condition0.93809301
53MP0000427_abnormal_hair_cycle0.93690195
54MP0003279_aneurysm0.90568731
55MP0003436_decreased_susceptibility_to0.88694258
56MP0003950_abnormal_plasma_membrane0.87351529
57MP0002006_tumorigenesis0.87097112
58MP0003091_abnormal_cell_migration0.86262270
59MP0008004_abnormal_stomach_pH0.82138251
60MP0005164_abnormal_response_to0.80871723
61MP0001756_abnormal_urination0.79694729
62MP0002877_abnormal_melanocyte_morpholog0.79314867
63MP0001849_ear_inflammation0.78636810
64MP0004883_abnormal_blood_vessel0.78051411
65MP0000858_altered_metastatic_potential0.77322227
66MP0005075_abnormal_melanosome_morpholog0.76503576
67MP0001765_abnormal_ion_homeostasis0.75226490
68MP0003183_abnormal_peptide_metabolism0.73006408
69MP0008438_abnormal_cutaneous_collagen0.72498813
70MP0005058_abnormal_lysosome_morphology0.71596041
71MP0000627_abnormal_mammary_gland0.70377053
72MP0009785_altered_susceptibility_to0.67396698
73MP0004885_abnormal_endolymph0.66988221
74MP0005666_abnormal_adipose_tissue0.66313685
75MP0000015_abnormal_ear_pigmentation0.66053957
76MP0001533_abnormal_skeleton_physiology0.65322812
77MP0005503_abnormal_tendon_morphology0.64066031
78MP0005387_immune_system_phenotype0.62228628
79MP0001790_abnormal_immune_system0.62228628
80MP0000678_abnormal_parathyroid_gland0.61180327
81MP0005025_abnormal_response_to0.57601345
82MP0010155_abnormal_intestine_physiology0.57075899
83MP0004272_abnormal_basement_membrane0.56072685
84MP0003828_pulmonary_edema0.55434097
85MP0001542_abnormal_bone_strength0.53619101
86MP0005410_abnormal_fertilization0.53067700
87MP0005083_abnormal_biliary_tract0.51628595
88MP0005174_abnormal_tail_pigmentation0.51604033
89MP0002133_abnormal_respiratory_system0.51459664
90MP0005388_respiratory_system_phenotype0.51459664
91MP0002168_other_aberrant_phenotype0.51033295
92MP0008260_abnormal_autophagy0.50644399
93MP0002998_abnormal_bone_remodeling0.50356294
94MP0003075_altered_response_to0.49919574
95MP0005167_abnormal_blood-brain_barrier0.49177437
96MP0010368_abnormal_lymphatic_system0.48867730
97MP0003303_peritoneal_inflammation0.48753502
98MP0009780_abnormal_chondrocyte_physiolo0.48640986
99MP0003638_abnormal_response/metabolism_0.48315419
100MP0002933_joint_inflammation0.46584672

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.19527903
2Increased IgE level (HP:0003212)7.02843004
3Plantar hyperkeratosis (HP:0007556)6.37838634
4Palmoplantar hyperkeratosis (HP:0000972)6.29615587
5Palmar hyperkeratosis (HP:0010765)5.89769562
6Pili torti (HP:0003777)5.79235534
7Hypotrichosis (HP:0001006)5.67644009
8Woolly hair (HP:0002224)5.50511799
9Abnormality of nail color (HP:0100643)5.31533748
10Alopecia of scalp (HP:0002293)5.00297330
11Erythema (HP:0010783)4.81842786
12Milia (HP:0001056)4.78561435
13Erythroderma (HP:0001019)4.76941465
14Amelogenesis imperfecta (HP:0000705)4.75400041
15Thick nail (HP:0001805)4.72060297
16Fragile nails (HP:0001808)4.70224859
17Right ventricular cardiomyopathy (HP:0011663)4.63419393
18Conjunctival hamartoma (HP:0100780)4.58011750
19Abnormality of the axillary hair (HP:0100134)4.41253206
20Abnormality of secondary sexual hair (HP:0009888)4.41253206
21Congenital ichthyosiform erythroderma (HP:0007431)4.41199679
22Abnormal hair laboratory examination (HP:0003328)4.22712391
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.85168303
24Nail dystrophy (HP:0008404)3.83764726
25Abnormal blistering of the skin (HP:0008066)3.69759809
26Slow-growing hair (HP:0002217)3.48721666
27Abnormality of hair growth rate (HP:0011363)3.48721666
28Interstitial pulmonary disease (HP:0006530)3.43317247
29Hamartoma of the eye (HP:0010568)3.30770055
30Corneal erosion (HP:0200020)3.14661395
31Atrophic scars (HP:0001075)3.07937413
32Lip pit (HP:0100267)2.94219070
33Brittle hair (HP:0002299)2.92261125
34Natal tooth (HP:0000695)2.90024178
35Absent eyelashes (HP:0000561)2.78384513
36Gangrene (HP:0100758)2.77148591
37Palmoplantar keratoderma (HP:0000982)2.65174622
38Sparse scalp hair (HP:0002209)2.63783328
39Dry hair (HP:0011359)2.55437894
40Advanced eruption of teeth (HP:0006288)2.52396134
41Follicular hyperkeratosis (HP:0007502)2.51160463
42Sparse eyelashes (HP:0000653)2.39858533
43Malnutrition (HP:0004395)2.33723394
44Ridged nail (HP:0001807)2.32090857
45Hypohidrosis (HP:0000966)2.30724678
46Aortic aneurysm (HP:0004942)2.30491573
47Hypoplasia of dental enamel (HP:0006297)2.29290364
48Ectropion (HP:0000656)2.29288578
49Absent hair (HP:0002298)2.18805630
50Parakeratosis (HP:0001036)2.17842059
51Hypergammaglobulinemia (HP:0010702)2.13783220
52Aortic dissection (HP:0002647)2.01778026
53Eczematoid dermatitis (HP:0000976)2.00788146
54Thin bony cortex (HP:0002753)1.98916007
55Abnormality of the neuromuscular junction (HP:0003398)1.97334276
56Fatigable weakness (HP:0003473)1.97334276
57Oral leukoplakia (HP:0002745)1.95012267
58Abnormality of liposaccharide metabolism (HP:0010968)1.94428714
59Abnormality of glycosphingolipid metabolism (HP:0004343)1.94428714
60Abnormality of glycolipid metabolism (HP:0010969)1.94428714
61Popliteal pterygium (HP:0009756)1.94119888
62Acanthosis nigricans (HP:0000956)1.85922783
63Hyperhidrosis (HP:0000975)1.83002268
64Skin ulcer (HP:0200042)1.81728492
65Pruritus (HP:0000989)1.81216632
66Abnormality of the salivary glands (HP:0010286)1.80297649
67Dehydration (HP:0001944)1.80022501
68Fine hair (HP:0002213)1.78223175
69Abnormality of the dental root (HP:0006486)1.77793335
70Taurodontia (HP:0000679)1.77793335
71Abnormality of permanent molar morphology (HP:0011071)1.77793335
72Corneal dystrophy (HP:0001131)1.76591300
73Obstructive sleep apnea (HP:0002870)1.76417866
74Cervical subluxation (HP:0003308)1.72592712
75Abnormality of molar (HP:0011077)1.72491890
76Abnormality of molar morphology (HP:0011070)1.72491890
77Abnormality of the costochondral junction (HP:0000919)1.72084826
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71385616
79Pulmonary artery stenosis (HP:0004415)1.67673717
80Broad face (HP:0000283)1.66539436
81Ventricular tachycardia (HP:0004756)1.65105665
82Neoplasm of the heart (HP:0100544)1.62685825
83Axonal loss (HP:0003447)1.62350326
84Abnormality of the dental pulp (HP:0006479)1.62042973
85Hypoplastic labia majora (HP:0000059)1.61294867
86Hamartoma (HP:0010566)1.60690328
87Aneurysm (HP:0002617)1.58275278
88Blepharitis (HP:0000498)1.53932562
89Increased cerebral lipofuscin (HP:0011813)1.52148603
90Laryngomalacia (HP:0001601)1.51449384
91Neonatal death (HP:0003811)1.51372382
92Septate vagina (HP:0001153)1.50885169
93Xerostomia (HP:0000217)1.50287243
94Aortic regurgitation (HP:0001659)1.50048089
95Systemic lupus erythematosus (HP:0002725)1.49865969
96Oligodontia (HP:0000677)1.48861667
97Conical tooth (HP:0000698)1.47863758
98Segmental peripheral demyelination/remyelination (HP:0003481)1.47281835
99Melanocytic nevus (HP:0000995)1.45547405
100Asymmetric septal hypertrophy (HP:0001670)1.45034399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK33.33172854
2ERN13.14551212
3TRIB32.97421827
4EEF2K2.90373039
5MAP3K62.70910250
6EPHA32.56886328
7SIK12.47364281
8RIPK12.47344873
9AKT32.33665235
10MYLK2.26110388
11MST1R2.19425249
12MAP3K32.03878092
13FER2.01817329
14EPHA21.96360684
15EPHB11.94036023
16CDC42BPA1.92060278
17MAP3K131.82163783
18PKN21.67900266
19FGFR41.67820600
20MAP2K61.66644772
21CAMK1D1.62996080
22MARK21.57678353
23DDR21.52941804
24MATK1.43117048
25TRPM71.41042916
26STK241.35522368
27TGFBR11.33473952
28ARAF1.33155126
29MAPK151.27817052
30DMPK1.25229135
31LATS11.24014224
32PTK21.23595643
33PIM21.22684372
34TESK11.19806891
35STK381.17762668
36EPHB21.14745132
37TGFBR21.12143548
38RPS6KA21.11742692
39PTK61.11077178
40CAMK1G1.10689538
41TAOK11.08831042
42CHUK1.01423383
43PRKD21.00058360
44MET0.92294988
45MTOR0.90073203
46MAP3K140.89566288
47TBK10.89340449
48FGFR30.88284499
49IKBKB0.87112148
50PRKAA20.86524571
51SGK30.85601695
52PIK3CG0.84536968
53SGK20.83031199
54SGK2230.82462908
55SGK4940.82462908
56MAPK120.81990636
57LMTK20.80736835
58DAPK20.79863209
59MAPKAPK50.79862575
60PDGFRB0.79135625
61TNK20.79022133
62PDGFRA0.77660807
63MAPK70.77224127
64NLK0.72405757
65TAOK30.70649004
66JAK10.70450401
67PAK20.69874303
68MAPKAPK20.67830889
69STK38L0.66074893
70MAP3K70.65251798
71ERBB20.62842272
72PDPK10.62765371
73HIPK20.62092387
74RPS6KB20.61577781
75ZAP700.61388255
76IRAK10.60848690
77CDK120.59109901
78RET0.59068983
79WNK10.58972722
80PRPF4B0.58056126
81MAP3K10.57630194
82KIT0.56416157
83MAP2K30.55472249
84JAK30.55175075
85GSK3A0.52692201
86MOS0.51632467
87ABL20.50995586
88ILK0.50480628
89TYK20.48856299
90NEK60.48136078
91GRK70.47566480
92MAPK40.45659083
93MAP3K20.45024988
94PRKD10.44023553
95PRKCI0.43199536
96LRRK20.42366003
97RPS6KC10.38286518
98RPS6KL10.38286518
99PAK40.36560345
100TTN0.35877676

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95303615
2Fatty acid biosynthesis_Homo sapiens_hsa000612.77323325
3Histidine metabolism_Homo sapiens_hsa003402.61971570
4Phenylalanine metabolism_Homo sapiens_hsa003602.31440947
5Mineral absorption_Homo sapiens_hsa049781.98287504
6beta-Alanine metabolism_Homo sapiens_hsa004101.67751341
7Fatty acid elongation_Homo sapiens_hsa000621.67011085
8Staphylococcus aureus infection_Homo sapiens_hsa051501.66963584
9ECM-receptor interaction_Homo sapiens_hsa045121.65787074
10Pertussis_Homo sapiens_hsa051331.58297829
11Vitamin digestion and absorption_Homo sapiens_hsa049771.56026068
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53937896
13Other glycan degradation_Homo sapiens_hsa005111.49633800
14Lysosome_Homo sapiens_hsa041421.48186034
15Sphingolipid metabolism_Homo sapiens_hsa006001.43630883
16Linoleic acid metabolism_Homo sapiens_hsa005911.42725393
17PPAR signaling pathway_Homo sapiens_hsa033201.35333057
18Allograft rejection_Homo sapiens_hsa053301.22763044
19Toxoplasmosis_Homo sapiens_hsa051451.21838533
20VEGF signaling pathway_Homo sapiens_hsa043701.20768806
21Fatty acid metabolism_Homo sapiens_hsa012121.19693825
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.19368423
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.18807389
24Amoebiasis_Homo sapiens_hsa051461.18338791
25* Arachidonic acid metabolism_Homo sapiens_hsa005901.12883197
26ABC transporters_Homo sapiens_hsa020101.11927608
27Renin-angiotensin system_Homo sapiens_hsa046141.06140548
28TNF signaling pathway_Homo sapiens_hsa046681.06092575
29Circadian rhythm_Homo sapiens_hsa047101.05925894
30Notch signaling pathway_Homo sapiens_hsa043301.05537929
31Tuberculosis_Homo sapiens_hsa051521.04890729
32Leishmaniasis_Homo sapiens_hsa051401.02601439
33Acute myeloid leukemia_Homo sapiens_hsa052211.02440108
34Tyrosine metabolism_Homo sapiens_hsa003501.01509958
35Malaria_Homo sapiens_hsa051441.00513511
36Ovarian steroidogenesis_Homo sapiens_hsa049130.99652554
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98715301
38Renin secretion_Homo sapiens_hsa049240.98212078
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.95799866
40Ether lipid metabolism_Homo sapiens_hsa005650.95755551
41Focal adhesion_Homo sapiens_hsa045100.94818258
42Type I diabetes mellitus_Homo sapiens_hsa049400.90555948
43GnRH signaling pathway_Homo sapiens_hsa049120.88608789
44Rheumatoid arthritis_Homo sapiens_hsa053230.86736403
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.86266466
46Influenza A_Homo sapiens_hsa051640.85929721
47Prostate cancer_Homo sapiens_hsa052150.85856688
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.85029655
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83258406
50Adherens junction_Homo sapiens_hsa045200.82540195
51Salivary secretion_Homo sapiens_hsa049700.81226606
52Graft-versus-host disease_Homo sapiens_hsa053320.81056988
53Osteoclast differentiation_Homo sapiens_hsa043800.80967998
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80302070
55Fatty acid degradation_Homo sapiens_hsa000710.79793771
56Steroid biosynthesis_Homo sapiens_hsa001000.77816594
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77461105
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.76669626
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75939504
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75610868
61Insulin resistance_Homo sapiens_hsa049310.75573536
62Autoimmune thyroid disease_Homo sapiens_hsa053200.73509120
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72614397
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72048587
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71432782
66Estrogen signaling pathway_Homo sapiens_hsa049150.70853039
67Asthma_Homo sapiens_hsa053100.70482518
68Fructose and mannose metabolism_Homo sapiens_hsa000510.69311943
69Hepatitis C_Homo sapiens_hsa051600.67462732
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.67364902
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67323740
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64875445
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64659310
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.64567846
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64378326
76Choline metabolism in cancer_Homo sapiens_hsa052310.63815993
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.62618357
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61841894
79Retinol metabolism_Homo sapiens_hsa008300.61563241
80Proteoglycans in cancer_Homo sapiens_hsa052050.60604987
81Tight junction_Homo sapiens_hsa045300.59890064
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59470217
83Bladder cancer_Homo sapiens_hsa052190.56360944
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54451348
85Endocytosis_Homo sapiens_hsa041440.53758817
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53428774
87Platelet activation_Homo sapiens_hsa046110.53395899
88MicroRNAs in cancer_Homo sapiens_hsa052060.52686824
89Phagosome_Homo sapiens_hsa041450.51243782
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49865370
91Complement and coagulation cascades_Homo sapiens_hsa046100.49310514
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.48291292
93Dorso-ventral axis formation_Homo sapiens_hsa043200.48014006
94Insulin signaling pathway_Homo sapiens_hsa049100.46377461
95Tryptophan metabolism_Homo sapiens_hsa003800.46287818
96Hematopoietic cell lineage_Homo sapiens_hsa046400.43163646
97Peroxisome_Homo sapiens_hsa041460.42098238
98Small cell lung cancer_Homo sapiens_hsa052220.41417405
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.41108299
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.40936300

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