ALOX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mast cell degranulation (GO:0043306)7.83910829
2positive regulation of mast cell activation involved in immune response (GO:0033008)7.83910829
3positive regulation of mast cell activation (GO:0033005)7.41239295
4leukocyte aggregation (GO:0070486)6.93197407
5cellular extravasation (GO:0045123)6.44936234
6leukocyte migration involved in inflammatory response (GO:0002523)6.32320530
7positive regulation of myeloid leukocyte mediated immunity (GO:0002888)6.26323875
8regulation of mast cell degranulation (GO:0043304)6.07136300
9positive regulation of leukocyte degranulation (GO:0043302)6.04281100
10positive regulation of gamma-delta T cell activation (GO:0046645)5.87464349
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.81135160
12regulation of mast cell activation involved in immune response (GO:0033006)5.77539842
13regulation of myeloid leukocyte mediated immunity (GO:0002886)5.50741213
14regulation of leukocyte degranulation (GO:0043300)5.43183987
15regulation of hypersensitivity (GO:0002883)5.41410141
16neutrophil activation involved in immune response (GO:0002283)5.34583157
17regulation of mast cell activation (GO:0033003)5.30990204
18antigen processing and presentation of endogenous antigen (GO:0019883)5.29546929
19detection of bacterium (GO:0016045)5.25639077
20angiotensin maturation (GO:0002003)5.19105876
21response to fungus (GO:0009620)5.17524188
22respiratory burst (GO:0045730)5.14948877
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11724881
24defense response to fungus (GO:0050832)4.96946491
25response to peptidoglycan (GO:0032494)4.69019919
26positive regulation of megakaryocyte differentiation (GO:0045654)4.68817163
27detection of external biotic stimulus (GO:0098581)4.63481811
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63007439
29actin nucleation (GO:0045010)4.55995907
30regulation of interferon-beta biosynthetic process (GO:0045357)4.52970608
31* leukotriene metabolic process (GO:0006691)4.50781015
32* production of molecular mediator involved in inflammatory response (GO:0002532)4.50285592
33regulation of regulated secretory pathway (GO:1903305)4.47247646
34positive regulation of regulated secretory pathway (GO:1903307)4.39380313
35detection of molecule of bacterial origin (GO:0032490)4.38937109
36regulation of B cell receptor signaling pathway (GO:0050855)4.38684481
37negative regulation of interleukin-12 production (GO:0032695)4.31961917
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.29465986
39thrombin receptor signaling pathway (GO:0070493)4.27505157
40* leukotriene biosynthetic process (GO:0019370)4.24480031
41regulation of gamma-delta T cell activation (GO:0046643)4.24095174
42tyrosine phosphorylation of STAT protein (GO:0007260)4.12358203
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09309116
44positive regulation by organism of defense response of other organism involved in symbiotic interact4.09309116
45modulation by symbiont of host immune response (GO:0052553)4.09309116
46positive regulation by symbiont of host defense response (GO:0052509)4.09309116
47modulation by symbiont of host defense response (GO:0052031)4.09309116
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09309116
49detection of biotic stimulus (GO:0009595)4.05868877
50positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.04829520
51negative regulation of lymphocyte mediated immunity (GO:0002707)4.02560603
52negative regulation of granulocyte differentiation (GO:0030853)4.02503205
53sequestering of metal ion (GO:0051238)3.98900201
54negative regulation of phagocytosis (GO:0050765)3.98743137
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.96408481
56microglial cell activation (GO:0001774)3.91686353
57neutrophil mediated immunity (GO:0002446)3.85466634
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.79079516
59neutrophil activation (GO:0042119)3.76694703
60mannose metabolic process (GO:0006013)3.76365534
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75242741
62negative regulation of cell killing (GO:0031342)3.75242741
63macrophage activation (GO:0042116)3.74736393
64regulation of gamma-delta T cell differentiation (GO:0045586)3.64283696
65neutrophil chemotaxis (GO:0030593)3.60378463
66negative regulation of leukocyte mediated immunity (GO:0002704)3.57944614
67immunoglobulin mediated immune response (GO:0016064)3.49872142
68neutrophil migration (GO:1990266)3.49702184
69B cell mediated immunity (GO:0019724)3.49582600
70granulocyte activation (GO:0036230)3.47711512
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47647267
72leukocyte cell-cell adhesion (GO:0007159)3.45051304
73response to host immune response (GO:0052572)3.44752141
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44752141
75regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.44689015
76* lipoxygenase pathway (GO:0019372)3.42862976
77response to interleukin-15 (GO:0070672)3.42099862
78cellular response to type I interferon (GO:0071357)3.40877396
79type I interferon signaling pathway (GO:0060337)3.40877396
80antigen processing and presentation via MHC class Ib (GO:0002475)3.39894604
81interferon-gamma-mediated signaling pathway (GO:0060333)3.39577940
82disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.38920492
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.38920492
84response to type I interferon (GO:0034340)3.38346460
85positive regulation of B cell differentiation (GO:0045579)3.38327577
86germinal center formation (GO:0002467)3.35623305
87response to muramyl dipeptide (GO:0032495)3.35005075
88defense response to protozoan (GO:0042832)3.33941946
89regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32283450
90negative regulation of T cell mediated immunity (GO:0002710)3.32190328
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.31802704
92megakaryocyte development (GO:0035855)3.31041277
93regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.30558164
94activated T cell proliferation (GO:0050798)3.28070359
95positive thymic T cell selection (GO:0045059)3.27498130
96regulation of T-helper 2 cell differentiation (GO:0045628)3.27472978
97leukocyte degranulation (GO:0043299)3.26207622
98myeloid cell activation involved in immune response (GO:0002275)3.25743367
99regulation of antigen processing and presentation (GO:0002577)3.24581547
100negative regulation of erythrocyte differentiation (GO:0045647)3.21245513
101regulation of B cell differentiation (GO:0045577)3.19391723
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18505990
103response to host (GO:0075136)3.18505990
104response to host defenses (GO:0052200)3.18505990
105regulation of T cell tolerance induction (GO:0002664)3.17946458
106positive regulation of chemokine secretion (GO:0090197)3.17832842
107regulation of tolerance induction (GO:0002643)3.17028186
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16606893
109positive regulation of cellular amide metabolic process (GO:0034250)3.14973264
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13646130
111macrophage differentiation (GO:0030225)3.09670324
112granulocyte chemotaxis (GO:0071621)3.09055837
113positive regulation of interferon-alpha production (GO:0032727)3.08926461
114hydrogen peroxide biosynthetic process (GO:0050665)3.05910528
115granulocyte migration (GO:0097530)3.05749911
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04486785
117lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04180894
118cellular response to interleukin-15 (GO:0071350)3.03429745
119superoxide anion generation (GO:0042554)3.00794044
120detection of other organism (GO:0098543)3.00787149
121negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99575187
122negative regulation of T-helper cell differentiation (GO:0045623)2.99575187
123mast cell activation (GO:0045576)2.99517867
124actin filament polymerization (GO:0030041)2.92866113
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92855310
126regulation of phagocytosis (GO:0050764)2.92709816
127response to protozoan (GO:0001562)2.92556430
128negative thymic T cell selection (GO:0045060)2.91881902
129positive regulation of antigen processing and presentation (GO:0002579)2.91881215
130* icosanoid biosynthetic process (GO:0046456)2.91513013
131* fatty acid derivative biosynthetic process (GO:1901570)2.91513013
132negative regulation of innate immune response (GO:0045824)2.91230949
133regulation of apoptotic cell clearance (GO:2000425)2.89733482
134negative regulation of interleukin-6 production (GO:0032715)2.89525190
135myeloid leukocyte activation (GO:0002274)2.88902584
136positive regulation of acute inflammatory response (GO:0002675)2.88071406
137regulation of interferon-alpha production (GO:0032647)2.87183546
138positive regulation of macrophage differentiation (GO:0045651)2.86685148
139macrophage activation involved in immune response (GO:0002281)2.85894174
140positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81375460
141dendritic cell migration (GO:0036336)2.78707978
142B cell receptor signaling pathway (GO:0050853)2.77797945
143citrulline biosynthetic process (GO:0019240)2.77282517
144reactive oxygen species biosynthetic process (GO:1903409)2.76439754
145granulocyte differentiation (GO:0030851)2.74982708
146mast cell activation involved in immune response (GO:0002279)2.73888485
147mast cell degranulation (GO:0043303)2.73888485
148cytokine metabolic process (GO:0042107)2.73751319
149regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73050165
150myeloid leukocyte mediated immunity (GO:0002444)2.72523137
151integrin-mediated signaling pathway (GO:0007229)2.70445596
152leukocyte mediated cytotoxicity (GO:0001909)2.68246339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.09766378
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.25077600
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.05852257
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.73417833
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.70444459
6SCL_19346495_ChIP-Seq_HPC-7_Human3.56935398
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44743704
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.43414632
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13472622
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06558726
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89753349
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.81994858
13BRD4_27068464_Chip-Seq_AML-cells_Mouse2.71159560
14VDR_21846776_ChIP-Seq_THP-1_Human2.67308484
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60848612
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51063682
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.45418510
18* SPI1_23547873_ChIP-Seq_NB4_Human2.44117961
19* RUNX1_22412390_ChIP-Seq_EML_Mouse2.39796194
20VDR_24763502_ChIP-Seq_THP-1_Human2.37036228
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15132903
22* SPI1_23127762_ChIP-Seq_K562_Human2.14949480
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08681514
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06726428
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06654335
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.01356490
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00249704
28MAF_26560356_Chip-Seq_TH1_Human2.00193571
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.98417098
30RUNX_20019798_ChIP-Seq_JUKART_Human1.95303635
31MYB_26560356_Chip-Seq_TH2_Human1.86051027
32E2F7_22180533_ChIP-Seq_HELA_Human1.82410142
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72785838
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71449181
35UTX_26944678_Chip-Seq_JUKART_Human1.70195259
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70036888
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69854787
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64952418
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.64503146
40MYC_22102868_ChIP-Seq_BL_Human1.62493611
41* GATA1_19941827_ChIP-Seq_MEL_Mouse1.61938174
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61244411
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55101347
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55096566
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52869599
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51885414
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50505722
48PU_27001747_Chip-Seq_BMDM_Mouse1.50258840
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.49365741
50KDM2B_26808549_Chip-Seq_DND41_Human1.45904981
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.45443415
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44792176
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43428609
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42898418
55MYB_26560356_Chip-Seq_TH1_Human1.42736235
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42274225
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40550977
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39414181
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37633425
60GATA1_19941826_ChIP-Seq_K562_Human1.37059847
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33720722
62GATA1_22025678_ChIP-Seq_K562_Human1.33302316
63VDR_24787735_ChIP-Seq_THP-1_Human1.33014574
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32307132
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31089374
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29500657
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28647783
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28450893
69GATA2_19941826_ChIP-Seq_K562_Human1.25620526
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22503621
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22045166
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17683717
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16303674
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14345092
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13279145
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11774050
77* LXR_22292898_ChIP-Seq_THP-1_Human1.11224046
78BCL6_27268052_Chip-Seq_Bcells_Human1.10997144
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.09367777
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08135093
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08068336
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07800826
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07697574
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.07371697
85SPI1_20517297_ChIP-Seq_HL60_Human1.06565572
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06452701
87EGR1_19032775_ChIP-ChIP_M12_Human1.05961829
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05621551
89BCOR_27268052_Chip-Seq_Bcells_Human1.05402519
90GATA3_27048872_Chip-Seq_THYMUS_Human1.03062968
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02758411
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00816375
93MAF_26560356_Chip-Seq_TH2_Human0.99857384
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99666178
95GATA3_26560356_Chip-Seq_TH2_Human0.95266428
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91896244
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91864877
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89778977
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87585871
100NCOR1_26117541_ChIP-Seq_K562_Human0.87299230
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87222665
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87132153
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86902304
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84144669
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81013292
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80207621
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79170242
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79000506
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78829023
110RACK7_27058665_Chip-Seq_MCF-7_Human0.75727612
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75119302
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74113762
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72011967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.71602526
2MP0003303_peritoneal_inflammation4.00491940
3MP0002148_abnormal_hypersensitivity_rea3.56384902
4* MP0002419_abnormal_innate_immunity3.25111707
5MP0005464_abnormal_platelet_physiology3.04465082
6MP0000465_gastrointestinal_hemorrhage2.92477415
7MP0004510_myositis2.84649338
8MP0005025_abnormal_response_to2.80073395
9MP0009278_abnormal_bone_marrow2.71265523
10MP0009785_altered_susceptibility_to2.69908299
11MP0001533_abnormal_skeleton_physiology2.69746524
12* MP0005000_abnormal_immune_tolerance2.66081373
13MP0005058_abnormal_lysosome_morphology2.58562718
14MP0001835_abnormal_antigen_presentation2.49400052
15MP0001800_abnormal_humoral_immune2.38040149
16MP0002452_abnormal_antigen_presenting2.36107547
17MP0002405_respiratory_system_inflammati2.33818363
18MP0003300_gastrointestinal_ulcer2.28970803
19* MP0002420_abnormal_adaptive_immunity2.25110326
20* MP0001819_abnormal_immune_cell2.24410307
21* MP0001790_abnormal_immune_system2.21213599
22* MP0005387_immune_system_phenotype2.21213599
23MP0003724_increased_susceptibility_to2.20826398
24MP0000343_altered_response_to2.17952306
25MP0002723_abnormal_immune_serum2.12178213
26MP0003566_abnormal_cell_adhesion2.11682157
27MP0003763_abnormal_thymus_physiology2.06060010
28MP0001851_eye_inflammation2.00557201
29MP0008260_abnormal_autophagy1.96602248
30MP0004808_abnormal_hematopoietic_stem1.96201332
31MP0003183_abnormal_peptide_metabolism1.90841600
32MP0000685_abnormal_immune_system1.90819507
33MP0003172_abnormal_lysosome_physiology1.86515561
34MP0004947_skin_inflammation1.83750403
35MP0005671_abnormal_response_to1.82913045
36MP0002877_abnormal_melanocyte_morpholog1.82608240
37MP0001853_heart_inflammation1.79415896
38MP0006082_CNS_inflammation1.76703457
39MP0002398_abnormal_bone_marrow1.76445867
40* MP0001845_abnormal_inflammatory_respons1.74307153
41MP0001545_abnormal_hematopoietic_system1.67414344
42MP0005397_hematopoietic_system_phenotyp1.67414344
43MP0000716_abnormal_immune_system1.67327152
44MP0003075_altered_response_to1.63915555
45MP0002132_abnormal_respiratory_system1.60173101
46MP0010155_abnormal_intestine_physiology1.59515204
47MP0002837_dystrophic_cardiac_calcinosis1.55095980
48MP0003191_abnormal_cellular_cholesterol1.54624090
49MP0009840_abnormal_foam_cell1.47565742
50MP0005451_abnormal_body_composition1.44474321
51MP0002933_joint_inflammation1.43731626
52MP0009333_abnormal_splenocyte_physiolog1.43659641
53MP0002429_abnormal_blood_cell1.42855000
54* MP0002722_abnormal_immune_system1.41291522
55MP0003448_altered_tumor_morphology1.40229082
56MP0008469_abnormal_protein_level1.39504849
57MP0005310_abnormal_salivary_gland1.37670182
58MP0002396_abnormal_hematopoietic_system1.36871731
59MP0001986_abnormal_taste_sensitivity1.34591043
60MP0003638_abnormal_response/metabolism_1.32909833
61MP0005390_skeleton_phenotype1.32896369
62* MP0000689_abnormal_spleen_morphology1.31218232
63MP0003828_pulmonary_edema1.29798000
64MP0005076_abnormal_cell_differentiation1.29317166
65MP0000490_abnormal_crypts_of1.28274826
66MP0004883_abnormal_blood_vessel1.28068562
67MP0009764_decreased_sensitivity_to1.25180178
68MP0000858_altered_metastatic_potential1.24257425
69MP0005023_abnormal_wound_healing1.21743237
70MP0002138_abnormal_hepatobiliary_system1.21582236
71MP0004381_abnormal_hair_follicle1.20213605
72MP0001873_stomach_inflammation1.17831486
73MP0005174_abnormal_tail_pigmentation1.11114639
74MP0003690_abnormal_glial_cell1.10885939
75MP0005166_decreased_susceptibility_to1.10232793
76MP0009763_increased_sensitivity_to1.07918694
77MP0010307_abnormal_tumor_latency1.01748830
78MP0009765_abnormal_xenobiotic_induced1.00887573
79MP0008004_abnormal_stomach_pH1.00649901
80MP0000249_abnormal_blood_vessel0.96397986
81MP0003656_abnormal_erythrocyte_physiolo0.94681816
82MP0000604_amyloidosis0.93687675
83MP0005164_abnormal_response_to0.91922640
84MP0003866_abnormal_defecation0.87550283
85MP0002998_abnormal_bone_remodeling0.87297869
86MP0000920_abnormal_myelination0.86910755
87MP0003279_aneurysm0.86713994
88MP0003453_abnormal_keratinocyte_physiol0.86515563
89MP0003045_fibrosis0.80072204
90MP0008873_increased_physiological_sensi0.79910772
91MP0005075_abnormal_melanosome_morpholog0.77436632
92MP0000703_abnormal_thymus_morphology0.75987164
93MP0002277_abnormal_respiratory_mucosa0.74770281
94MP0001663_abnormal_digestive_system0.74590027
95MP0010352_gastrointestinal_tract_polyps0.73562759
96MP0003705_abnormal_hypodermis_morpholog0.72708413
97MP0003806_abnormal_nucleotide_metabolis0.72701985
98MP0000767_abnormal_smooth_muscle0.70181590
99* MP0003795_abnormal_bone_structure0.68605324
100MP0000015_abnormal_ear_pigmentation0.67900783
101MP0002166_altered_tumor_susceptibility0.66676953
102MP0001915_intracranial_hemorrhage0.65294856
103MP0002006_tumorigenesis0.63682154
104MP0001958_emphysema0.59078240
105MP0003329_amyloid_beta_deposits0.58477112
106MP0000733_abnormal_muscle_development0.57296676
107MP0002133_abnormal_respiratory_system0.56055537
108MP0005388_respiratory_system_phenotype0.56055537
109MP0003221_abnormal_cardiomyocyte_apopto0.54257139
110MP0009931_abnormal_skin_appearance0.52128731
111MP0005167_abnormal_blood-brain_barrier0.51705756
112MP0001216_abnormal_epidermal_layer0.50679818
113MP0008874_decreased_physiological_sensi0.48436258
114MP0005319_abnormal_enzyme/_coenzyme0.48383126
115MP0008438_abnormal_cutaneous_collagen0.48320674
116MP0003091_abnormal_cell_migration0.47564959
117MP0002332_abnormal_exercise_endurance0.47328397
118MP0002693_abnormal_pancreas_physiology0.46962372
119MP0000609_abnormal_liver_physiology0.46550435
120MP0002009_preneoplasia0.45316841

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.86057841
2Eczematoid dermatitis (HP:0000976)7.09914347
3Recurrent gram-negative bacterial infections (HP:0005420)6.82861659
4Recurrent bacterial skin infections (HP:0005406)6.73092127
5Petechiae (HP:0000967)6.39686643
6Systemic lupus erythematosus (HP:0002725)5.42625157
7Prolonged bleeding time (HP:0003010)4.68027183
8Abnormal platelet volume (HP:0011876)4.62038776
9Purpura (HP:0000979)4.60715308
10Abnormality of macrophages (HP:0004311)4.58039146
11Menorrhagia (HP:0000132)4.37689231
12Increased mean platelet volume (HP:0011877)4.36680058
13Chronic obstructive pulmonary disease (HP:0006510)4.22181588
14Obstructive lung disease (HP:0006536)4.22181588
15Gingivitis (HP:0000230)4.02133362
16Recurrent skin infections (HP:0001581)4.01987349
17Gingival bleeding (HP:0000225)3.99601586
18Mediastinal lymphadenopathy (HP:0100721)3.98102139
19Recurrent fungal infections (HP:0002841)3.91310652
20Gastrointestinal infarctions (HP:0005244)3.89324862
21Cellulitis (HP:0100658)3.86221762
22Vacuolated lymphocytes (HP:0001922)3.84502541
23Abnormal platelet function (HP:0011869)3.75884377
24Impaired platelet aggregation (HP:0003540)3.75884377
25Encephalitis (HP:0002383)3.53747022
26Keratoconjunctivitis sicca (HP:0001097)3.49177544
27Urticaria (HP:0001025)3.39169018
28Dysostosis multiplex (HP:0000943)3.28854017
29Increased cerebral lipofuscin (HP:0011813)3.21346608
30Keratoconjunctivitis (HP:0001096)3.20393527
31Glomerulonephritis (HP:0000099)3.14884599
32Epistaxis (HP:0000421)3.12910946
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.09359095
34Hypochromic microcytic anemia (HP:0004840)3.08788190
35Pulmonary infiltrates (HP:0002113)3.01298479
36Agammaglobulinemia (HP:0004432)2.98846273
37Hemoptysis (HP:0002105)2.97253954
38Myositis (HP:0100614)2.96788523
39Spontaneous hematomas (HP:0007420)2.94761342
40Akinesia (HP:0002304)2.94537320
41Episodic fever (HP:0001954)2.83385308
42Panhypogammaglobulinemia (HP:0003139)2.81940321
43IgM deficiency (HP:0002850)2.79247794
44Hypochromic anemia (HP:0001931)2.78683265
45Stomatitis (HP:0010280)2.77844074
46Mucopolysacchariduria (HP:0008155)2.74388340
47Urinary glycosaminoglycan excretion (HP:0003541)2.74388340
48T lymphocytopenia (HP:0005403)2.68148915
49Recurrent viral infections (HP:0004429)2.65830631
50Pustule (HP:0200039)2.63798344
51Periodontitis (HP:0000704)2.63270949
52Meningitis (HP:0001287)2.62639504
53Chronic otitis media (HP:0000389)2.60994563
54Gastrointestinal stroma tumor (HP:0100723)2.60906233
55Abnormality of complement system (HP:0005339)2.56973947
56Abnormality of T cell number (HP:0011839)2.56868974
57Lymphopenia (HP:0001888)2.55382949
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54436402
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54436402
60Abnormality of polysaccharide metabolism (HP:0011012)2.54436402
61Pulmonary embolism (HP:0002204)2.54153021
62Anorexia (HP:0002039)2.52636913
63Interstitial pulmonary disease (HP:0006530)2.50888157
64Orchitis (HP:0100796)2.49036577
65Amyloidosis (HP:0011034)2.44813451
66Papilledema (HP:0001085)2.43590124
67Abnormality of T cells (HP:0002843)2.40682923
68Thoracic kyphosis (HP:0002942)2.37125002
69Leukocytosis (HP:0001974)2.36663944
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.36393823
71Increased density of long bones (HP:0006392)2.33063478
72Abnormality of the pleura (HP:0002103)2.32417441
73Increased IgM level (HP:0003496)2.31845889
74Abnormality of liposaccharide metabolism (HP:0010968)2.30411674
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.30411674
76Abnormality of glycolipid metabolism (HP:0010969)2.30411674
77J-shaped sella turcica (HP:0002680)2.30300187
78Recurrent bronchitis (HP:0002837)2.29311248
79Abnormality of the peritoneum (HP:0002585)2.28881785
80Amniotic constriction ring (HP:0009775)2.28145553
81Abnormality of placental membranes (HP:0011409)2.28145553
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27766270
83Recurrent sinusitis (HP:0011108)2.26412145
84Osteolytic defects of the hand bones (HP:0009699)2.26102210
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.26102210
86Abnormality of the lumbar spine (HP:0100712)2.25445557
87Recurrent cutaneous fungal infections (HP:0011370)2.23353276
88Chronic mucocutaneous candidiasis (HP:0002728)2.23353276
89Granulocytopenia (HP:0001913)2.23066745
90Inflammation of the large intestine (HP:0002037)2.20873748
91Premature loss of primary teeth (HP:0006323)2.20691348
92Hypergammaglobulinemia (HP:0010702)2.17466684
93Gangrene (HP:0100758)2.16853794
94Microcytic anemia (HP:0001935)2.15766351
95Abnormality of T cell physiology (HP:0011840)2.15758280
96Restrictive lung disease (HP:0002091)2.14071372
97Viral hepatitis (HP:0006562)2.12627471
98Recurrent lower respiratory tract infections (HP:0002783)2.12153548
99Spondylolisthesis (HP:0003302)2.10657150
100Papilloma (HP:0012740)2.07681278
101Verrucae (HP:0200043)2.07681278
102Fetal akinesia sequence (HP:0001989)2.05737067
103Optic neuritis (HP:0100653)2.05226762
104Retrobulbar optic neuritis (HP:0100654)2.05226762
105Cervical subluxation (HP:0003308)2.04779242
106Gastrointestinal inflammation (HP:0004386)2.04309721
107Elevated erythrocyte sedimentation rate (HP:0003565)2.03689886
108Arterial thrombosis (HP:0004420)2.02995523
109Slender build (HP:0001533)2.02399565
110Hematochezia (HP:0002573)2.02137163
111Increased serum ferritin (HP:0003281)2.00131123
112Thick nail (HP:0001805)1.99047293
113Osteomyelitis (HP:0002754)1.98698089
114Abnormality of the endocardium (HP:0004306)1.98438841
115Skin rash (HP:0000988)1.97575197
116Glomerulopathy (HP:0100820)1.97052922
117Popliteal pterygium (HP:0009756)1.96486723
118Hepatosplenomegaly (HP:0001433)1.96055119
119Loss of speech (HP:0002371)1.95583110
120Abnormality of the thoracic spine (HP:0100711)1.93079033
121Abnormality of iron homeostasis (HP:0011031)1.92422629
122Nephritis (HP:0000123)1.91183051
123Slow saccadic eye movements (HP:0000514)1.90777859
124Vertigo (HP:0002321)1.88037283
125Cerebral aneurysm (HP:0004944)1.87549952
126Colitis (HP:0002583)1.86373892
127Nasal polyposis (HP:0100582)1.84377217
128Complement deficiency (HP:0004431)1.84182265
129Peritonitis (HP:0002586)1.84020690
130Easy fatigability (HP:0003388)1.83594987
131Recurrent pneumonia (HP:0006532)1.82911616
132Vasculitis (HP:0002633)1.80437444
133Bruising susceptibility (HP:0000978)1.80277884
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.80121111
135Increased IgE level (HP:0003212)1.78938184
136Abnormality of the nasal mucosa (HP:0000433)1.77389770
137Sepsis (HP:0100806)1.76209035
138Chest pain (HP:0100749)1.75909420
139Axonal loss (HP:0003447)1.75762044
140Ulnar deviation of the wrist (HP:0003049)1.74467343
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73675766
142Skin ulcer (HP:0200042)1.72592473
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71328166
144Aplasia of the musculature (HP:0100854)1.70589255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.05446576
2IRAK44.02879098
3BLK3.48749077
4EPHB13.36622900
5FES2.79574726
6RIPK42.78106170
7TRPM72.71519647
8KIT2.45754164
9STK102.34004811
10TRIB32.27368781
11TNK22.19746795
12BTK2.16416864
13CSK2.11009941
14TYK22.07263979
15EEF2K1.93778023
16FGR1.90049027
17ERN11.79404323
18HCK1.76468255
19TEC1.72258859
20CLK11.71891521
21TTN1.70639348
22TAOK11.69989471
23MATK1.64483605
24TGFBR21.57730101
25TAOK31.56959541
26PKN21.56666430
27TXK1.56058237
28ZAP701.54620225
29MAP3K131.49849566
30GRK61.38622225
31ITK1.38448308
32IRAK31.38028288
33LRRK21.36191354
34CAMK1D1.35695654
35MAP2K31.34283067
36SYK1.32900064
37MST1R1.29632552
38SIK31.27334931
39CAMK1G1.26757572
40TBK11.25119582
41MAP3K11.22882907
42DMPK1.22504778
43ERBB31.18323909
44CSF1R1.14765239
45YES11.14030571
46PTK61.13661511
47MAPKAPK51.13388131
48PIM21.11488470
49LYN1.07233124
50BMPR21.07000799
51MARK21.06140503
52IRAK21.01287101
53IRAK10.98491844
54CDK60.97588765
55PAK40.95437707
56BMX0.92726402
57PDK10.91337002
58LCK0.89355515
59MAP3K60.89263748
60JAK20.89093844
61PIK3CG0.88671115
62PIM10.88464994
63MAPKAPK30.87574957
64PTK20.87058571
65PRKD20.86920973
66TAOK20.85638347
67TESK20.83989560
68CDC42BPA0.80029436
69MAP3K140.77706462
70ALK0.74539566
71JAK10.73346900
72RPS6KA20.72867770
73MAPK120.72243367
74STK40.70769110
75MOS0.70475041
76CDK190.68094672
77PRKCQ0.68076086
78SMG10.67457571
79IKBKB0.67034922
80RPS6KA60.66603596
81KSR20.65592374
82MAP3K20.65551262
83RPS6KC10.64595388
84RPS6KL10.64595388
85SIK20.64111965
86MAP3K110.63974326
87MARK30.63668403
88MAP3K70.61519396
89STK240.60717269
90MAPK70.59456466
91KDR0.58016336
92CDK120.57351983
93FGFR30.56940924
94FGFR40.56426147
95JAK30.56345820
96MAPK40.55899010
97MAP2K40.54391108
98SIK10.53999459
99MAP3K50.52083193
100STK110.51660946
101HIPK20.51429589
102FYN0.49505400
103SGK30.49148726
104IKBKE0.47905532
105RPS6KB20.47451176
106PRKCH0.46377116
107DYRK1B0.45618008
108NEK90.45369176
109PRKCD0.44956600
110MAP3K30.44912579
111MAP2K60.44844749
112MAP3K80.43488825
113DAPK20.42861148
114RIPK10.42457339
115ROCK20.42159300
116ABL10.42046733
117EPHA30.41695253
118* MAPKAPK20.41230191
119RET0.40940357
120PRKG20.40723750
121PRPF4B0.40281607
122EGFR0.39122214
123MAP2K20.39075302
124GRK70.37845749
125NLK0.37820201
126MAP3K120.35563440
127TESK10.34730761
128RAF10.33542489
129LIMK10.33516996
130MAP3K100.33147885
131RPS6KA40.32810831
132CDK90.32575787
133SGK20.31324833
134CAMKK10.31185414
135IGF1R0.30440059
136SRC0.29572242
137MAP2K10.29317648
138PRKCZ0.29262741
139KSR10.28735190
140STK380.28572551
141PDPK10.28259995
142PTK2B0.28215157
143PRKD10.28154071

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.03104322
2Asthma_Homo sapiens_hsa053103.82753159
3Leishmaniasis_Homo sapiens_hsa051403.26867050
4Renin-angiotensin system_Homo sapiens_hsa046142.91267332
5Other glycan degradation_Homo sapiens_hsa005112.85892434
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.84956921
7Autoimmune thyroid disease_Homo sapiens_hsa053202.55716770
8Osteoclast differentiation_Homo sapiens_hsa043802.41065635
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.40844842
10B cell receptor signaling pathway_Homo sapiens_hsa046622.15947662
11Primary immunodeficiency_Homo sapiens_hsa053402.10206363
12Pertussis_Homo sapiens_hsa051332.08382353
13Type I diabetes mellitus_Homo sapiens_hsa049402.06690885
14Leukocyte transendothelial migration_Homo sapiens_hsa046702.03480689
15Hematopoietic cell lineage_Homo sapiens_hsa046402.03276165
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.99628985
17Platelet activation_Homo sapiens_hsa046111.97045121
18Tuberculosis_Homo sapiens_hsa051521.82490159
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76223771
20Lysosome_Homo sapiens_hsa041421.64854546
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60558966
22Shigellosis_Homo sapiens_hsa051311.58836562
23Chemokine signaling pathway_Homo sapiens_hsa040621.53387068
24Phagosome_Homo sapiens_hsa041451.48084504
25Complement and coagulation cascades_Homo sapiens_hsa046101.38284909
26Viral myocarditis_Homo sapiens_hsa054161.37687779
27Malaria_Homo sapiens_hsa051441.37131922
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36749149
29Salmonella infection_Homo sapiens_hsa051321.35987385
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35958845
31Legionellosis_Homo sapiens_hsa051341.32881297
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29411966
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28435974
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28024215
35Apoptosis_Homo sapiens_hsa042101.27672029
36* Toxoplasmosis_Homo sapiens_hsa051451.26375823
37Acute myeloid leukemia_Homo sapiens_hsa052211.24442722
38Pancreatic cancer_Homo sapiens_hsa052121.23937394
39Chronic myeloid leukemia_Homo sapiens_hsa052201.23898610
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.19097293
41Amoebiasis_Homo sapiens_hsa051461.15085529
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.14050989
43Hepatitis B_Homo sapiens_hsa051611.11597166
44African trypanosomiasis_Homo sapiens_hsa051431.10793498
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10077658
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.09937536
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.08114171
48VEGF signaling pathway_Homo sapiens_hsa043701.05111489
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.02416798
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01088719
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00214855
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98167740
53Measles_Homo sapiens_hsa051620.95567832
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83727959
55Endocytosis_Homo sapiens_hsa041440.83717657
56TNF signaling pathway_Homo sapiens_hsa046680.82562163
57Rheumatoid arthritis_Homo sapiens_hsa053230.82006881
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.81453116
59Non-small cell lung cancer_Homo sapiens_hsa052230.78893054
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78529213
61Influenza A_Homo sapiens_hsa051640.76813631
62Caffeine metabolism_Homo sapiens_hsa002320.71937648
63Proteoglycans in cancer_Homo sapiens_hsa052050.70121496
64Focal adhesion_Homo sapiens_hsa045100.69788741
65T cell receptor signaling pathway_Homo sapiens_hsa046600.66807919
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66540166
67Renal cell carcinoma_Homo sapiens_hsa052110.64792927
68Colorectal cancer_Homo sapiens_hsa052100.64743664
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63802002
70Rap1 signaling pathway_Homo sapiens_hsa040150.63664670
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62925437
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62646021
73Allograft rejection_Homo sapiens_hsa053300.61340621
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59683284
75Graft-versus-host disease_Homo sapiens_hsa053320.59532147
76GnRH signaling pathway_Homo sapiens_hsa049120.58400669
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57685372
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57682005
79HTLV-I infection_Homo sapiens_hsa051660.54629301
80FoxO signaling pathway_Homo sapiens_hsa040680.54220348
81Herpes simplex infection_Homo sapiens_hsa051680.53961094
82* Arachidonic acid metabolism_Homo sapiens_hsa005900.53659361
83Antigen processing and presentation_Homo sapiens_hsa046120.53404354
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.52698611
85Hepatitis C_Homo sapiens_hsa051600.51883690
86HIF-1 signaling pathway_Homo sapiens_hsa040660.51841495
87Endometrial cancer_Homo sapiens_hsa052130.50940748
88Type II diabetes mellitus_Homo sapiens_hsa049300.49370999
89Viral carcinogenesis_Homo sapiens_hsa052030.48434729
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48066797
91Dorso-ventral axis formation_Homo sapiens_hsa043200.46885199
92Small cell lung cancer_Homo sapiens_hsa052220.45892703
93Inositol phosphate metabolism_Homo sapiens_hsa005620.44466808
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44250084
95Prion diseases_Homo sapiens_hsa050200.43974925
96Insulin resistance_Homo sapiens_hsa049310.43670591
97mTOR signaling pathway_Homo sapiens_hsa041500.43525311
98Bladder cancer_Homo sapiens_hsa052190.41952172
99p53 signaling pathway_Homo sapiens_hsa041150.41938036
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.41416587
101Sphingolipid metabolism_Homo sapiens_hsa006000.41106267
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41014427
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40437109
104MAPK signaling pathway_Homo sapiens_hsa040100.39976461
105ECM-receptor interaction_Homo sapiens_hsa045120.39765293
106Choline metabolism in cancer_Homo sapiens_hsa052310.39408011
107Pentose phosphate pathway_Homo sapiens_hsa000300.38299724
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38138311
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37243328
110Steroid biosynthesis_Homo sapiens_hsa001000.35639207
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35575242
112Dilated cardiomyopathy_Homo sapiens_hsa054140.35473094
113Pathways in cancer_Homo sapiens_hsa052000.35321456
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35075420
115Glioma_Homo sapiens_hsa052140.34842558
116Adherens junction_Homo sapiens_hsa045200.34491565
117Prostate cancer_Homo sapiens_hsa052150.34301018
118Epstein-Barr virus infection_Homo sapiens_hsa051690.33670719
119MicroRNAs in cancer_Homo sapiens_hsa052060.32117815
120Systemic lupus erythematosus_Homo sapiens_hsa053220.32003731
121Notch signaling pathway_Homo sapiens_hsa043300.31153172
122Regulation of autophagy_Homo sapiens_hsa041400.30809439
123Pancreatic secretion_Homo sapiens_hsa049720.29726966
124Prolactin signaling pathway_Homo sapiens_hsa049170.29655513
125ErbB signaling pathway_Homo sapiens_hsa040120.29470608

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