ALOX5AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.32797536
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.29895139
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.42257180
4negative regulation of cell killing (GO:0031342)5.42257180
5response to peptidoglycan (GO:0032494)5.40768211
6respiratory burst (GO:0045730)5.29235057
7immunoglobulin mediated immune response (GO:0016064)5.04153134
8positive regulation by symbiont of host defense response (GO:0052509)4.95979123
9modulation by symbiont of host defense response (GO:0052031)4.95979123
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95979123
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95979123
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.95979123
13modulation by symbiont of host immune response (GO:0052553)4.95979123
14cellular extravasation (GO:0045123)4.52350502
15regulation of B cell receptor signaling pathway (GO:0050855)4.50502631
16neutrophil activation (GO:0042119)4.36172758
17response to interleukin-15 (GO:0070672)4.30929414
18positive regulation of mast cell activation (GO:0033005)4.30639784
19cellular response to interleukin-15 (GO:0071350)4.29420589
20positive regulation of mast cell degranulation (GO:0043306)4.23060921
21positive regulation of mast cell activation involved in immune response (GO:0033008)4.23060921
22granulocyte activation (GO:0036230)4.20137254
23regulation of gamma-delta T cell activation (GO:0046643)4.19420113
24leukocyte aggregation (GO:0070486)4.16528526
25cytidine metabolic process (GO:0046087)4.15408320
26cytidine catabolic process (GO:0006216)4.15408320
27cytidine deamination (GO:0009972)4.15408320
28regulation of mast cell degranulation (GO:0043304)4.14522666
29macrophage activation involved in immune response (GO:0002281)4.12042634
30regulation of interferon-beta biosynthetic process (GO:0045357)4.05842568
31regulation of mast cell activation (GO:0033003)4.02987965
32Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00358092
33myeloid cell activation involved in immune response (GO:0002275)3.97907646
34neutrophil mediated immunity (GO:0002446)3.94386229
35detection of external biotic stimulus (GO:0098581)3.93511372
36regulation of gamma-delta T cell differentiation (GO:0045586)3.92495330
37B cell mediated immunity (GO:0019724)3.90119573
38regulation of mast cell activation involved in immune response (GO:0033006)3.86829599
39positive regulation of interferon-alpha production (GO:0032727)3.81488971
40pyrimidine ribonucleoside catabolic process (GO:0046133)3.80005174
41T cell migration (GO:0072678)3.70404561
42positive regulation of antigen processing and presentation (GO:0002579)3.70214324
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.70072112
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69503416
45mast cell activation (GO:0045576)3.69414605
46superoxide anion generation (GO:0042554)3.64961759
47defense response to protozoan (GO:0042832)3.62094270
48regulation of interferon-alpha production (GO:0032647)3.60636351
49positive regulation of B cell differentiation (GO:0045579)3.58122916
50response to interferon-beta (GO:0035456)3.53888225
51response to host immune response (GO:0052572)3.53093729
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53093729
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52444551
54regulation of T cell tolerance induction (GO:0002664)3.52190618
55detection of biotic stimulus (GO:0009595)3.49990896
56response to muramyl dipeptide (GO:0032495)3.49006833
57reactive oxygen species biosynthetic process (GO:1903409)3.46993222
58negative regulation of leukocyte mediated immunity (GO:0002704)3.46627472
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.46078607
60hydrogen peroxide biosynthetic process (GO:0050665)3.44854878
61lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44410265
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43877906
63regulation of B cell differentiation (GO:0045577)3.43303104
64pinocytosis (GO:0006907)3.42590871
65negative regulation of T cell mediated immunity (GO:0002710)3.39568538
66response to protozoan (GO:0001562)3.37592834
67leukocyte mediated cytotoxicity (GO:0001909)3.37576284
68regulation of leukocyte degranulation (GO:0043300)3.37097254
69detection of other organism (GO:0098543)3.36933120
70positive regulation of gamma-delta T cell activation (GO:0046645)3.36699052
71regulation of tolerance induction (GO:0002643)3.35123623
72negative T cell selection (GO:0043383)3.34765643
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.33546266
74negative thymic T cell selection (GO:0045060)3.30421037
75interferon-gamma-mediated signaling pathway (GO:0060333)3.28065651
76leukocyte degranulation (GO:0043299)3.27734038
77myeloid dendritic cell activation (GO:0001773)3.25691944
78neutrophil chemotaxis (GO:0030593)3.25380655
79positive thymic T cell selection (GO:0045059)3.24929227
80antigen processing and presentation of endogenous antigen (GO:0019883)3.24403140
81negative regulation of mast cell activation (GO:0033004)3.23255933
82lymphocyte chemotaxis (GO:0048247)3.22999410
83response to host (GO:0075136)3.21338603
84response to host defenses (GO:0052200)3.21338603
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21338603
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20868144
87regulation of antigen processing and presentation (GO:0002577)3.20839948
88response to fungus (GO:0009620)3.20783594
89negative regulation of interleukin-12 production (GO:0032695)3.20166941
90microglial cell activation (GO:0001774)3.19573644
91cellular response to type I interferon (GO:0071357)3.17088829
92type I interferon signaling pathway (GO:0060337)3.17088829
93neutrophil migration (GO:1990266)3.16201758
94positive regulation of leukocyte degranulation (GO:0043302)3.15879476
95* production of molecular mediator involved in inflammatory response (GO:0002532)3.15874409
96dendritic cell chemotaxis (GO:0002407)3.14781943
97myeloid leukocyte activation (GO:0002274)3.14778092
98negative regulation of myeloid cell apoptotic process (GO:0033033)3.14234662
99regulation of alpha-beta T cell proliferation (GO:0046640)3.14168813
100response to type I interferon (GO:0034340)3.13758623
101macrophage activation (GO:0042116)3.13746665
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12496141
103leukocyte migration involved in inflammatory response (GO:0002523)3.11170419
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10897706
105antigen processing and presentation via MHC class Ib (GO:0002475)3.09899374
106regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.09401830
107actin nucleation (GO:0045010)3.08647390
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07854055
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07854055
110cellular response to exogenous dsRNA (GO:0071360)3.06420257
111myeloid leukocyte mediated immunity (GO:0002444)3.04023554
112cellular response to interferon-beta (GO:0035458)3.02295833
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02127571
114regulation of natural killer cell mediated immunity (GO:0002715)3.00513632
115regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00513632
116response to interferon-alpha (GO:0035455)3.00131617
117activated T cell proliferation (GO:0050798)3.00000805
118regulation of regulatory T cell differentiation (GO:0045589)2.99773576
119dendritic cell migration (GO:0036336)2.98559277
120tolerance induction (GO:0002507)2.98310263
121negative regulation of phagocytosis (GO:0050765)2.97978125
122negative regulation of cytokine production involved in immune response (GO:0002719)2.96523883
123regulation of T cell mediated cytotoxicity (GO:0001914)2.96138761
124regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95979186
125myeloid dendritic cell differentiation (GO:0043011)2.95070592
126T cell selection (GO:0045058)2.94220600
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93562118
128positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93100724
129positive T cell selection (GO:0043368)2.92297267
130cellular response to zinc ion (GO:0071294)2.91749342
131granulocyte chemotaxis (GO:0071621)2.89909583
132detection of bacterium (GO:0016045)2.89340013
133positive regulation of interferon-beta production (GO:0032728)2.88055466
134positive regulation of lymphocyte migration (GO:2000403)2.87778847
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86080329
136B cell receptor signaling pathway (GO:0050853)2.85216189
137positive regulation of monocyte chemotaxis (GO:0090026)2.84559922
138leukocyte mediated immunity (GO:0002443)2.82307490
139negative regulation of interleukin-17 production (GO:0032700)2.82166186
140positive regulation of T cell migration (GO:2000406)2.82143203
141detection of molecule of bacterial origin (GO:0032490)2.82074490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.51025584
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.99982633
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.22182909
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.99716197
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.97276309
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.82478743
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76968301
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.51685056
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42823206
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18006630
11SCL_19346495_ChIP-Seq_HPC-7_Human3.05400990
12E2F7_22180533_ChIP-Seq_HELA_Human3.00314161
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91083083
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79787536
15* SPI1_23547873_ChIP-Seq_NB4_Human2.79111506
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.71033901
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.68481158
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64519497
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58784553
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51693448
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48660042
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.41561668
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40907600
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28765200
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19619230
26VDR_24763502_ChIP-Seq_THP-1_Human2.13709828
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.12112590
28VDR_21846776_ChIP-Seq_THP-1_Human2.08987861
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.03405887
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00662473
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90389670
32* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.88530441
33* MYB_26560356_Chip-Seq_TH2_Human1.88290373
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87585022
35SPI1_23127762_ChIP-Seq_K562_Human1.85525560
36PU_27001747_Chip-Seq_BMDM_Mouse1.76169861
37MAF_26560356_Chip-Seq_TH1_Human1.72598643
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.68544256
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68520421
40RUNX_20019798_ChIP-Seq_JUKART_Human1.63949901
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63213460
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62485379
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61369524
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60870741
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56216860
46MYB_26560356_Chip-Seq_TH1_Human1.55317299
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54519338
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53933330
49* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47822935
50* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45067576
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43664412
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42492432
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39379027
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36664764
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35131490
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33169925
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32576038
58MYC_22102868_ChIP-Seq_BL_Human1.30895176
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29918887
60* UTX_26944678_Chip-Seq_JUKART_Human1.27830066
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27685273
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26206054
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25343242
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25315939
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24554322
66* TCF7_22412390_ChIP-Seq_EML_Mouse1.21508348
67KDM2B_26808549_Chip-Seq_DND41_Human1.16518464
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16362491
69GATA3_27048872_Chip-Seq_THYMUS_Human1.14602767
70VDR_24787735_ChIP-Seq_THP-1_Human1.14562733
71* GATA3_26560356_Chip-Seq_TH2_Human1.14434409
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.13542874
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12848320
74GATA1_22025678_ChIP-Seq_K562_Human1.07696639
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07560770
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07310795
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.06999414
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03162204
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.01589120
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01230449
81* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98521275
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98044481
83BCOR_27268052_Chip-Seq_Bcells_Human0.95046340
84MAF_26560356_Chip-Seq_TH2_Human0.94685554
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91056160
86SPI1_20517297_ChIP-Seq_HL60_Human0.90500907
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89964163
88TFEB_21752829_ChIP-Seq_HELA_Human0.89198967
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87852064
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87533776
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86735009
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86155669
93* LXR_22292898_ChIP-Seq_THP-1_Human0.80725467
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.78018541
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77336366
96* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75619283
97* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74677224
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74563655
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.74187466
100SMRT_27268052_Chip-Seq_Bcells_Human0.71833960
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71408490
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70827642
103ELK1_19687146_ChIP-ChIP_HELA_Human0.69265912
104GATA2_19941826_ChIP-Seq_K562_Human0.69114306
105BCL6_27268052_Chip-Seq_Bcells_Human0.68588485
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68082720
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67450227
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.66748867
109GATA1_19941826_ChIP-Seq_K562_Human0.66316166
110EGR1_19032775_ChIP-ChIP_M12_Human0.65889149
111E2F4_17652178_ChIP-ChIP_JURKAT_Human0.65132123
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61927040
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61568205
114* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60805529
115VDR_23849224_ChIP-Seq_CD4+_Human0.60736368
116* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.59515881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.97257111
2* MP0003436_decreased_susceptibility_to3.88308708
3MP0009785_altered_susceptibility_to3.66831050
4* MP0002148_abnormal_hypersensitivity_rea3.61747386
5* MP0002419_abnormal_innate_immunity3.41301963
6MP0005025_abnormal_response_to3.15043424
7* MP0005000_abnormal_immune_tolerance3.12489214
8MP0003303_peritoneal_inflammation3.03008681
9MP0003724_increased_susceptibility_to2.92694392
10MP0002452_abnormal_antigen_presenting2.76093033
11MP0005058_abnormal_lysosome_morphology2.75306501
12MP0000685_abnormal_immune_system2.73200604
13MP0005464_abnormal_platelet_physiology2.70453486
14MP0005387_immune_system_phenotype2.67561469
15MP0001790_abnormal_immune_system2.67561469
16MP0005671_abnormal_response_to2.62838196
17MP0001800_abnormal_humoral_immune2.59647654
18MP0002723_abnormal_immune_serum2.54726195
19* MP0001819_abnormal_immune_cell2.45742380
20* MP0002420_abnormal_adaptive_immunity2.44090507
21MP0006082_CNS_inflammation2.40777689
22MP0001853_heart_inflammation2.21677659
23MP0002405_respiratory_system_inflammati2.17780268
24MP0009278_abnormal_bone_marrow2.03977954
25MP0005397_hematopoietic_system_phenotyp1.99346031
26MP0001545_abnormal_hematopoietic_system1.99346031
27MP0000343_altered_response_to1.96878653
28* MP0001533_abnormal_skeleton_physiology1.95569704
29* MP0001845_abnormal_inflammatory_respons1.93997416
30MP0003172_abnormal_lysosome_physiology1.89893161
31MP0000716_abnormal_immune_system1.84191278
32MP0002396_abnormal_hematopoietic_system1.83557886
33MP0002398_abnormal_bone_marrow1.82424882
34MP0010155_abnormal_intestine_physiology1.80622663
35MP0000465_gastrointestinal_hemorrhage1.77506652
36MP0004510_myositis1.76532183
37MP0005174_abnormal_tail_pigmentation1.71246035
38MP0003075_altered_response_to1.69953684
39MP0009333_abnormal_splenocyte_physiolog1.66672917
40MP0008469_abnormal_protein_level1.64164204
41MP0000689_abnormal_spleen_morphology1.61611975
42MP0009764_decreased_sensitivity_to1.59527585
43MP0003191_abnormal_cellular_cholesterol1.56905549
44MP0002429_abnormal_blood_cell1.56156621
45MP0004808_abnormal_hematopoietic_stem1.53070452
46MP0004947_skin_inflammation1.48959797
47MP0002722_abnormal_immune_system1.48609837
48MP0005310_abnormal_salivary_gland1.41016785
49MP0002006_tumorigenesis1.39760301
50MP0002166_altered_tumor_susceptibility1.38608236
51MP0003183_abnormal_peptide_metabolism1.38317803
52MP0000490_abnormal_crypts_of1.38299410
53MP0003448_altered_tumor_morphology1.38173620
54MP0000858_altered_metastatic_potential1.38045245
55MP0003300_gastrointestinal_ulcer1.24106413
56MP0004381_abnormal_hair_follicle1.22508905
57MP0005166_decreased_susceptibility_to1.17935221
58MP0003828_pulmonary_edema1.17703467
59MP0009840_abnormal_foam_cell1.11988937
60MP0001873_stomach_inflammation1.10521594
61MP0002998_abnormal_bone_remodeling1.08638670
62MP0003763_abnormal_thymus_physiology1.07699135
63MP0003866_abnormal_defecation1.07451609
64MP0003045_fibrosis1.06117652
65MP0005167_abnormal_blood-brain_barrier1.04910045
66MP0004782_abnormal_surfactant_physiolog1.03825283
67MP0005451_abnormal_body_composition1.03601052
68MP0001851_eye_inflammation1.01018094
69MP0002933_joint_inflammation1.00762183
70MP0002277_abnormal_respiratory_mucosa0.99180811
71MP0009763_increased_sensitivity_to0.95511177
72MP0010307_abnormal_tumor_latency0.91973349
73* MP0005390_skeleton_phenotype0.90330683
74MP0003186_abnormal_redox_activity0.90164824
75MP0000015_abnormal_ear_pigmentation0.88503853
76MP0003806_abnormal_nucleotide_metabolis0.88384894
77MP0005075_abnormal_melanosome_morpholog0.83194345
78MP0005164_abnormal_response_to0.82964118
79MP0003656_abnormal_erythrocyte_physiolo0.81898546
80MP0002138_abnormal_hepatobiliary_system0.81733264
81MP0000703_abnormal_thymus_morphology0.81244250
82MP0008004_abnormal_stomach_pH0.79845920
83MP0002095_abnormal_skin_pigmentation0.76577062
84MP0009765_abnormal_xenobiotic_induced0.76422889
85MP0000249_abnormal_blood_vessel0.76399135
86MP0000371_diluted_coat_color0.76163988
87MP0001986_abnormal_taste_sensitivity0.76031751
88MP0001663_abnormal_digestive_system0.74720520
89MP0000569_abnormal_digit_pigmentation0.72589344
90MP0002132_abnormal_respiratory_system0.72435958
91MP0003690_abnormal_glial_cell0.72129468
92MP0003566_abnormal_cell_adhesion0.71171833
93MP0000604_amyloidosis0.70097269
94MP0002019_abnormal_tumor_incidence0.69384585
95MP0003795_abnormal_bone_structure0.67204522
96MP0004883_abnormal_blood_vessel0.64937295
97MP0008260_abnormal_autophagy0.63337549
98MP0000920_abnormal_myelination0.63193316
99MP0008873_increased_physiological_sensi0.59635464
100MP0006054_spinal_hemorrhage0.57420532
101MP0010352_gastrointestinal_tract_polyps0.56367146
102MP0008874_decreased_physiological_sensi0.53535840
103MP0000767_abnormal_smooth_muscle0.52047321
104MP0002136_abnormal_kidney_physiology0.51376069
105MP0000313_abnormal_cell_death0.50165401
106MP0005319_abnormal_enzyme/_coenzyme0.49700364
107MP0001958_emphysema0.48999369
108MP0002693_abnormal_pancreas_physiology0.48037976
109MP0008007_abnormal_cellular_replicative0.47978485
110MP0005023_abnormal_wound_healing0.46903598
111MP0005076_abnormal_cell_differentiation0.46453163
112MP0000609_abnormal_liver_physiology0.45908249
113MP0004130_abnormal_muscle_cell0.45580899
114MP0005584_abnormal_enzyme/coenzyme_acti0.42208955
115MP0002254_reproductive_system_inflammat0.40509078

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.78689631
2Recurrent bacterial skin infections (HP:0005406)6.96078916
3Eczematoid dermatitis (HP:0000976)6.73311264
4Recurrent gram-negative bacterial infections (HP:0005420)5.93336104
5Abnormality of macrophages (HP:0004311)4.90553944
6Myositis (HP:0100614)4.84922338
7Vacuolated lymphocytes (HP:0001922)4.69472585
8Elevated erythrocyte sedimentation rate (HP:0003565)4.53571144
9Mediastinal lymphadenopathy (HP:0100721)4.46920114
10Obstructive lung disease (HP:0006536)4.43203312
11Chronic obstructive pulmonary disease (HP:0006510)4.43203312
12Recurrent skin infections (HP:0001581)4.37944165
13Abnormality of T cell number (HP:0011839)4.31198901
14Systemic lupus erythematosus (HP:0002725)4.29966775
15T lymphocytopenia (HP:0005403)4.23441241
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.13322257
17Increased cerebral lipofuscin (HP:0011813)4.06123883
18Recurrent fungal infections (HP:0002841)3.92830118
19Orchitis (HP:0100796)3.90285956
20Gingivitis (HP:0000230)3.85596196
21Autoimmune hemolytic anemia (HP:0001890)3.63566252
22Optic neuritis (HP:0100653)3.59611062
23Retrobulbar optic neuritis (HP:0100654)3.59611062
24Cellulitis (HP:0100658)3.56531468
25Hypochromic microcytic anemia (HP:0004840)3.51610270
26Petechiae (HP:0000967)3.39319820
27Meningitis (HP:0001287)3.36367642
28Increased IgM level (HP:0003496)3.31399771
29Spontaneous hematomas (HP:0007420)3.27058382
30Hypochromic anemia (HP:0001931)3.24773514
31Recurrent viral infections (HP:0004429)3.24771656
32IgM deficiency (HP:0002850)3.11561216
33Thrombocytosis (HP:0001894)3.09965286
34Stomatitis (HP:0010280)3.07663794
35Recurrent cutaneous fungal infections (HP:0011370)3.04912002
36Chronic mucocutaneous candidiasis (HP:0002728)3.04912002
37Pustule (HP:0200039)2.96741968
38Vasculitis (HP:0002633)2.96348506
39Abnormality of liposaccharide metabolism (HP:0010968)2.95543599
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.95543599
41Abnormality of glycolipid metabolism (HP:0010969)2.95543599
42Periodontitis (HP:0000704)2.95366715
43Agnosia (HP:0010524)2.95154222
44Dysostosis multiplex (HP:0000943)2.90908113
45Glomerulonephritis (HP:0000099)2.89746770
46Urticaria (HP:0001025)2.88018517
47Autoimmune thrombocytopenia (HP:0001973)2.86212100
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85894129
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.85227515
50Disinhibition (HP:0000734)2.85060110
51Granulocytopenia (HP:0001913)2.84487401
52Interstitial pulmonary disease (HP:0006530)2.81641110
53Prolonged bleeding time (HP:0003010)2.79587651
54Axonal loss (HP:0003447)2.76685597
55Chronic otitis media (HP:0000389)2.66916398
56Epistaxis (HP:0000421)2.66827658
57Anorexia (HP:0002039)2.66373536
58Eosinophilia (HP:0001880)2.65814810
59Gangrene (HP:0100758)2.61868516
60Basal ganglia calcification (HP:0002135)2.61461687
61Recurrent pneumonia (HP:0006532)2.57281922
62Episodic fever (HP:0001954)2.57256777
63Abnormality of the prostate (HP:0008775)2.54854378
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.53717447
65Lymphopenia (HP:0001888)2.53096816
66Prostate neoplasm (HP:0100787)2.52680589
67Arterial thrombosis (HP:0004420)2.48762517
68Poor head control (HP:0002421)2.47916558
69Abnormality of eosinophils (HP:0001879)2.47645416
70Gingival bleeding (HP:0000225)2.47127616
71Pulmonary infiltrates (HP:0002113)2.46621961
72Osteomyelitis (HP:0002754)2.44326662
73Keratoconjunctivitis sicca (HP:0001097)2.40644083
74Urinary glycosaminoglycan excretion (HP:0003541)2.38498162
75Mucopolysacchariduria (HP:0008155)2.38498162
76Recurrent lower respiratory tract infections (HP:0002783)2.37934204
77Loss of speech (HP:0002371)2.37749837
78Hemoptysis (HP:0002105)2.37267721
79Abnormality of T cell physiology (HP:0011840)2.37152258
80Inflammation of the large intestine (HP:0002037)2.37076785
81Leukocytosis (HP:0001974)2.35882543
82Joint swelling (HP:0001386)2.31648207
83Amyloidosis (HP:0011034)2.27273628
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26779535
85Encephalitis (HP:0002383)2.25531920
86Gastrointestinal inflammation (HP:0004386)2.24538149
87Colitis (HP:0002583)2.23747226
88Chest pain (HP:0100749)2.23446647
89Microcytic anemia (HP:0001935)2.23349873
90Recurrent bronchitis (HP:0002837)2.22358390
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21593801
92Abnormality of polysaccharide metabolism (HP:0011012)2.21593801
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21593801
94Premature loss of primary teeth (HP:0006323)2.19617938
95Hematochezia (HP:0002573)2.19479727
96Glomerulopathy (HP:0100820)2.18416689
97Hepatosplenomegaly (HP:0001433)2.17931899
98Keratoconjunctivitis (HP:0001096)2.17611907
99Panhypogammaglobulinemia (HP:0003139)2.17316369
100IgG deficiency (HP:0004315)2.17085603
101Purpura (HP:0000979)2.15430677
102Chronic diarrhea (HP:0002028)2.14973782
103Gastrointestinal infarctions (HP:0005244)2.13749129
104Abnormal platelet function (HP:0011869)2.13734191
105Impaired platelet aggregation (HP:0003540)2.13734191
106Polyneuropathy (HP:0001271)2.12726889
107Abnormality of the pericardium (HP:0001697)2.10295354
108Joint hemorrhage (HP:0005261)2.07848431
109Increased serum ferritin (HP:0003281)2.07393189
110Thoracic kyphosis (HP:0002942)2.04512205
111Skin rash (HP:0000988)2.04427941
112Abnormality of iron homeostasis (HP:0011031)1.99858160
113Sepsis (HP:0100806)1.99718610
114Hypergammaglobulinemia (HP:0010702)1.98374512
115Peritonitis (HP:0002586)1.98213316
116Skin ulcer (HP:0200042)1.97188409
117Severe combined immunodeficiency (HP:0004430)1.96545370
118Vertigo (HP:0002321)1.95462625
119Abnormality of the pleura (HP:0002103)1.93298724
120Abnormality of T cells (HP:0002843)1.92694691
121Albinism (HP:0001022)1.92591986
122Abnormality of the peritoneum (HP:0002585)1.91741838
123Nephritis (HP:0000123)1.91071714
124Pulmonary embolism (HP:0002204)1.90864011
125Increased IgE level (HP:0003212)1.90306404
126J-shaped sella turcica (HP:0002680)1.89995985
127Acne (HP:0001061)1.89892319
128Abnormality of the endocardium (HP:0004306)1.89881582
129Thick nail (HP:0001805)1.89567530
130Keratitis (HP:0000491)1.89004449
131Abnormality of complement system (HP:0005339)1.85396300
132Abnormality of the nasal mucosa (HP:0000433)1.85324978
133Agammaglobulinemia (HP:0004432)1.81320510
134Reduced antithrombin III activity (HP:0001976)1.79098993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.23127139
2IRAK44.09085259
3RIPK43.54941055
4MAP4K13.39669241
5KIT3.05586200
6MAP3K142.87418734
7TBK12.69860444
8IRAK32.63018772
9TEC2.51608570
10BTK2.41506537
11TYK22.28735939
12NME22.15633879
13TXK1.95698786
14CSF1R1.92755754
15IKBKE1.92700013
16IKBKB1.89612654
17TAOK31.86462414
18PIM21.83855086
19ZAP701.81172937
20TGFBR21.81031240
21JAK31.73770781
22ERN11.73337894
23SYK1.73307404
24TESK21.68193272
25CSK1.66131774
26MAP2K31.62439994
27FES1.59790081
28MAP3K121.46713719
29HCK1.46200969
30MATK1.44809598
31LYN1.44798979
32CLK11.40418552
33MAP3K31.37876737
34TAOK11.33359999
35PRPF4B1.33049002
36FLT31.32162758
37EPHB11.27682437
38STK101.27613154
39PIM11.21992783
40TRPM71.15424914
41NEK91.13864115
42LCK1.11691181
43CDK191.03523197
44MAP3K11.03196653
45JAK11.03059781
46FGR0.98605871
47GRK70.97893926
48ITK0.95920382
49RPS6KA40.95905762
50CHUK0.93284578
51JAK20.86623832
52LRRK20.81627683
53ADRBK20.81601575
54PRKCQ0.80850733
55YES10.78665717
56PDPK10.76174112
57PBK0.75451842
58PIK3CA0.74441397
59ABL20.72794816
60MAP3K110.71027020
61STK40.70517858
62PRKCD0.69849537
63KSR20.68953657
64PAK40.66998951
65MAPK120.64749182
66EIF2AK20.64645006
67MAP3K130.64546176
68BMPR20.63135140
69ERBB30.61387728
70RPS6KA60.60368719
71EPHA30.59290163
72GRK60.57837484
73ABL10.57135338
74PIK3CG0.55764267
75KDR0.54515808
76TGFBR10.53467293
77MARK20.52210793
78PKN20.52055510
79MAPKAPK20.50834723
80PRKG20.50140766
81MOS0.50054948
82CAMKK20.48418254
83RPS6KL10.48236797
84RPS6KC10.48236797
85TLK10.47501305
86IRAK20.47184861
87PTK60.45773404
88PRKD20.45753743
89RET0.45059839
90SIK20.44651281
91STK240.44483883
92MUSK0.43786289
93MARK30.43180632
94MAPK40.42769455
95HIPK20.40973905
96BMX0.40721809
97EGFR0.40374139
98TAOK20.40111258
99SCYL20.39805269
100IRAK10.38423276
101PDK10.35324610
102MAP3K20.35314913
103MAP2K60.34999073
104TNK20.34764236
105STK110.34719252
106SIK30.34598988
107MAPK70.34024611
108MAP3K60.33400300
109FGFR40.33125378
110MAP3K50.32970694
111DAPK10.32894971
112CDK60.30744588
113EIF2AK30.30718855
114FGFR30.30560070
115MAP2K40.28310672
116VRK10.28078005
117PTK2B0.27727563
118RIPK10.27524213
119MST1R0.26799052
120DAPK20.26339405
121TIE10.25884141
122MKNK10.25218844
123CAMK1D0.24953581
124FYN0.24657815
125MAPKAPK50.24572010
126NLK0.24089470
127CAMKK10.23868671
128CDC42BPA0.23617161
129IGF1R0.23398559
130INSR0.23016623
131MAP3K70.21090127

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.61346356
2Staphylococcus aureus infection_Homo sapiens_hsa051503.59231659
3Legionellosis_Homo sapiens_hsa051342.53427319
4Other glycan degradation_Homo sapiens_hsa005112.48512523
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48483880
6Pertussis_Homo sapiens_hsa051332.48462390
7Osteoclast differentiation_Homo sapiens_hsa043802.42919351
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38538926
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.19651703
10Tuberculosis_Homo sapiens_hsa051522.18285756
11Lysosome_Homo sapiens_hsa041422.18281543
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.11267051
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07780209
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98164827
15Asthma_Homo sapiens_hsa053101.96232156
16Malaria_Homo sapiens_hsa051441.90049462
17Measles_Homo sapiens_hsa051621.89209447
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89078937
19B cell receptor signaling pathway_Homo sapiens_hsa046621.88385530
20Salmonella infection_Homo sapiens_hsa051321.79640506
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.75532166
22Graft-versus-host disease_Homo sapiens_hsa053321.73880510
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69673318
24Phagosome_Homo sapiens_hsa041451.69500282
25Hematopoietic cell lineage_Homo sapiens_hsa046401.68245306
26Allograft rejection_Homo sapiens_hsa053301.64312941
27Antigen processing and presentation_Homo sapiens_hsa046121.58054633
28Influenza A_Homo sapiens_hsa051641.55112038
29Toxoplasmosis_Homo sapiens_hsa051451.54262805
30Shigellosis_Homo sapiens_hsa051311.54214689
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53426962
32Herpes simplex infection_Homo sapiens_hsa051681.52377545
33Rheumatoid arthritis_Homo sapiens_hsa053231.50443876
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43713728
35Chemokine signaling pathway_Homo sapiens_hsa040621.41288800
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.33278764
37TNF signaling pathway_Homo sapiens_hsa046681.33163869
38Apoptosis_Homo sapiens_hsa042101.32506624
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31822640
40Primary immunodeficiency_Homo sapiens_hsa053401.28047775
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26746967
42DNA replication_Homo sapiens_hsa030301.26323733
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23058351
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.20543575
45Platelet activation_Homo sapiens_hsa046111.10207862
46Hepatitis B_Homo sapiens_hsa051611.07906518
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99425778
48Ribosome_Homo sapiens_hsa030100.94612779
49African trypanosomiasis_Homo sapiens_hsa051430.94511505
50Acute myeloid leukemia_Homo sapiens_hsa052210.94404994
51Viral myocarditis_Homo sapiens_hsa054160.93116899
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88616130
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87018601
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83875481
55Caffeine metabolism_Homo sapiens_hsa002320.83786462
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82602649
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81902422
58Type I diabetes mellitus_Homo sapiens_hsa049400.79482909
59Complement and coagulation cascades_Homo sapiens_hsa046100.78924326
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77974440
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75531613
62Base excision repair_Homo sapiens_hsa034100.74886148
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74678595
64Hepatitis C_Homo sapiens_hsa051600.72281114
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68709832
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65253978
67Amoebiasis_Homo sapiens_hsa051460.64245788
68Epstein-Barr virus infection_Homo sapiens_hsa051690.63555254
69Homologous recombination_Homo sapiens_hsa034400.63360889
70Pancreatic cancer_Homo sapiens_hsa052120.61611979
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61076026
72Mismatch repair_Homo sapiens_hsa034300.58417671
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.58022966
74Arachidonic acid metabolism_Homo sapiens_hsa005900.57952278
75Chronic myeloid leukemia_Homo sapiens_hsa052200.57687987
76T cell receptor signaling pathway_Homo sapiens_hsa046600.56081461
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55039282
78Autoimmune thyroid disease_Homo sapiens_hsa053200.54522609
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51862295
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49499431
81Regulation of autophagy_Homo sapiens_hsa041400.48199957
82Collecting duct acid secretion_Homo sapiens_hsa049660.46560891
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46053060
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43700339
85Renin-angiotensin system_Homo sapiens_hsa046140.42852898
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.42156334
87Viral carcinogenesis_Homo sapiens_hsa052030.39475825
88Pentose phosphate pathway_Homo sapiens_hsa000300.39443376
89Renal cell carcinoma_Homo sapiens_hsa052110.39418747
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.39229823
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38018233
92p53 signaling pathway_Homo sapiens_hsa041150.36887989
93Sphingolipid metabolism_Homo sapiens_hsa006000.34752113
94N-Glycan biosynthesis_Homo sapiens_hsa005100.34292853
95Prolactin signaling pathway_Homo sapiens_hsa049170.33362012
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.32807590
97HIF-1 signaling pathway_Homo sapiens_hsa040660.31637388
98FoxO signaling pathway_Homo sapiens_hsa040680.29775329
99VEGF signaling pathway_Homo sapiens_hsa043700.29376064
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28764144
101Non-homologous end-joining_Homo sapiens_hsa034500.28401493
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27908742
103Proteasome_Homo sapiens_hsa030500.27807030
104Systemic lupus erythematosus_Homo sapiens_hsa053220.27001526
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24832980
106Type II diabetes mellitus_Homo sapiens_hsa049300.24767038
107MAPK signaling pathway_Homo sapiens_hsa040100.24723418
108Endocytosis_Homo sapiens_hsa041440.24573853
109Pyrimidine metabolism_Homo sapiens_hsa002400.24226080
110Small cell lung cancer_Homo sapiens_hsa052220.23446637
111Insulin resistance_Homo sapiens_hsa049310.22786314
112Non-small cell lung cancer_Homo sapiens_hsa052230.20912002
113HTLV-I infection_Homo sapiens_hsa051660.20905911
114Choline metabolism in cancer_Homo sapiens_hsa052310.19778753
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19642333
116mTOR signaling pathway_Homo sapiens_hsa041500.19048164
117Dorso-ventral axis formation_Homo sapiens_hsa043200.18969577
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18157825
119Notch signaling pathway_Homo sapiens_hsa043300.17789976
120GnRH signaling pathway_Homo sapiens_hsa049120.17707234
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.15603634
122Rap1 signaling pathway_Homo sapiens_hsa040150.14960814

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