ALOXE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of water loss via skin (GO:0033561)9.07320459
2desmosome organization (GO:0002934)8.64262922
3* multicellular organismal water homeostasis (GO:0050891)6.09548848
4keratinocyte differentiation (GO:0030216)5.52655754
5* water homeostasis (GO:0030104)5.23720316
6phosphatidylserine acyl-chain remodeling (GO:0036150)4.94076298
7phosphatidylinositol acyl-chain remodeling (GO:0036149)4.85310434
8peptide cross-linking (GO:0018149)4.76132929
9glucosamine-containing compound catabolic process (GO:1901072)4.74167481
10oocyte development (GO:0048599)4.50667317
11surfactant homeostasis (GO:0043129)4.44114084
12gap junction assembly (GO:0016264)4.36983179
13sphingoid metabolic process (GO:0046519)4.28895902
14* long-chain fatty acid biosynthetic process (GO:0042759)4.25304551
15keratinocyte proliferation (GO:0043616)4.24567927
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.16563326
17molting cycle (GO:0042303)4.14438896
18hair cycle (GO:0042633)4.14438896
19negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.14291892
20detection of other organism (GO:0098543)4.07759281
21detection of bacterium (GO:0016045)4.05596978
22* linoleic acid metabolic process (GO:0043651)4.05582663
23polarized epithelial cell differentiation (GO:0030859)4.05480214
24superoxide anion generation (GO:0042554)3.97299648
25fatty acid elongation (GO:0030497)3.97030939
26epidermal cell differentiation (GO:0009913)3.89133476
27phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.86088082
28keratinocyte development (GO:0003334)3.84012042
29negative regulation of interferon-gamma production (GO:0032689)3.70477341
30positive regulation of epidermal cell differentiation (GO:0045606)3.68037057
31positive regulation of epidermis development (GO:0045684)3.67994827
32regulation of keratinocyte differentiation (GO:0045616)3.66827656
33regulation of retinoic acid receptor signaling pathway (GO:0048385)3.60848570
34negative regulation of keratinocyte proliferation (GO:0010839)3.60628864
35regulation of natural killer cell differentiation (GO:0032823)3.57250640
36intermediate filament organization (GO:0045109)3.56628406
37regulation of DNA methylation (GO:0044030)3.53550802
38positive regulation of monocyte chemotaxis (GO:0090026)3.53525356
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.50315920
40hemidesmosome assembly (GO:0031581)3.47173257
41regulation of ruffle assembly (GO:1900027)3.46155198
42phosphatidylcholine acyl-chain remodeling (GO:0036151)3.45385662
43sphingosine metabolic process (GO:0006670)3.42955186
44epidermis development (GO:0008544)3.40442679
45regulation of acrosome reaction (GO:0060046)3.35141606
46regulation of keratinocyte proliferation (GO:0010837)3.33449026
47epithelial cell differentiation involved in prostate gland development (GO:0060742)3.30563054
48epithelium development (GO:0060429)3.29025119
49atrioventricular valve morphogenesis (GO:0003181)3.24116593
50wound healing, spreading of epidermal cells (GO:0035313)3.21234784
51interleukin-1-mediated signaling pathway (GO:0070498)3.21022895
52* lipoxygenase pathway (GO:0019372)3.18405794
53phosphatidylserine metabolic process (GO:0006658)3.18198320
54epithelial cell-cell adhesion (GO:0090136)3.17207379
55positive regulation of keratinocyte differentiation (GO:0045618)3.16136013
56diol metabolic process (GO:0034311)3.13615857
57intestinal epithelial cell development (GO:0060576)3.12810874
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06875719
59cell-substrate junction assembly (GO:0007044)3.03703469
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03272641
61lateral sprouting from an epithelium (GO:0060601)3.02607384
62ventricular cardiac muscle cell action potential (GO:0086005)3.00116393
63regulation of transforming growth factor beta1 production (GO:0032908)2.99632302
64regulation of epidermis development (GO:0045682)2.98469733
65ceramide catabolic process (GO:0046514)2.96426568
66regulation of hypersensitivity (GO:0002883)2.87153472
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.85841854
68positive regulation of vesicle fusion (GO:0031340)2.82204010
69skin morphogenesis (GO:0043589)2.81995673
70regulation of epidermal cell differentiation (GO:0045604)2.81547676
71amino sugar catabolic process (GO:0046348)2.79157552
72regulation of cell proliferation involved in kidney development (GO:1901722)2.75875167
73regulation of cardioblast differentiation (GO:0051890)2.74175624
74phospholipid scrambling (GO:0017121)2.70088803
75cellular response to arsenic-containing substance (GO:0071243)2.68703901
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68624855
77cyclooxygenase pathway (GO:0019371)2.68123208
78phospholipid catabolic process (GO:0009395)2.66935841
79phagosome maturation (GO:0090382)2.66557903
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.62960238
81positive regulation of mast cell degranulation (GO:0043306)2.62960238
82ectoderm development (GO:0007398)2.62469055
83detection of external biotic stimulus (GO:0098581)2.62384090
84wound healing, spreading of cells (GO:0044319)2.60484815
85regulation of hair cycle (GO:0042634)2.59079739
86alditol phosphate metabolic process (GO:0052646)2.58538656
87prostaglandin biosynthetic process (GO:0001516)2.58166641
88prostanoid biosynthetic process (GO:0046457)2.58166641
89regulation of interleukin-8 secretion (GO:2000482)2.57021630
90protein kinase C signaling (GO:0070528)2.56348535
91glycine transport (GO:0015816)2.52992362
92negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51920460
93multicellular organism reproduction (GO:0032504)2.51111014
94fat-soluble vitamin catabolic process (GO:0042363)2.50822024
95vitamin catabolic process (GO:0009111)2.50822024
96positive regulation of cellular amide metabolic process (GO:0034250)2.49153685
97negative regulation of epidermis development (GO:0045683)2.47473651
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47450716
99negative regulation of interleukin-17 production (GO:0032700)2.46069766
100positive regulation of hair follicle development (GO:0051798)2.44464146
101positive regulation of hair cycle (GO:0042635)2.44464146
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42802601
103neutrophil activation involved in immune response (GO:0002283)2.42702114
104* ceramide biosynthetic process (GO:0046513)2.41975515
105regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.41960560
106skin development (GO:0043588)2.39317439
107regulation of neuron projection regeneration (GO:0070570)2.39036995
108regulation of axon regeneration (GO:0048679)2.39036995
109dendritic spine organization (GO:0097061)2.38757756
110regulation of meiosis I (GO:0060631)2.38749126
111response to peptidoglycan (GO:0032494)2.37863910
112morphogenesis of embryonic epithelium (GO:0016331)2.37343733
113positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.36372197
114cell-cell junction assembly (GO:0007043)2.36314940
115detection of biotic stimulus (GO:0009595)2.34523940
116eosinophil chemotaxis (GO:0048245)2.33560854
117epithelial cell differentiation (GO:0030855)2.33229294
118chemical homeostasis within a tissue (GO:0048875)2.33215280
119regulation of monocyte chemotaxis (GO:0090025)2.32619691
120positive regulation of humoral immune response (GO:0002922)2.32172660
121regulation of phospholipase A2 activity (GO:0032429)2.31993841
122positive regulation of Cdc42 GTPase activity (GO:0043089)2.30949170
123regulation of cholesterol homeostasis (GO:2000188)2.29793697
124cell communication involved in cardiac conduction (GO:0086065)2.29548438
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.29081519
126G1 DNA damage checkpoint (GO:0044783)2.28856024
127intermediate filament cytoskeleton organization (GO:0045104)2.28698551
128molting cycle process (GO:0022404)2.27547903
129hair cycle process (GO:0022405)2.27547903
130T-helper cell differentiation (GO:0042093)2.27372846
131CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.27372846
132epithelial cell proliferation (GO:0050673)2.26117152
133intermediate filament-based process (GO:0045103)2.25992844
134positive regulation of interleukin-6 production (GO:0032755)2.25190261
135neurotransmitter-gated ion channel clustering (GO:0072578)2.24903989
136establishment of planar polarity (GO:0001736)2.24503247
137establishment of tissue polarity (GO:0007164)2.24503247
138negative regulation of T cell mediated immunity (GO:0002710)2.24045156
139positive regulation of glomerulus development (GO:0090193)2.23874893
140mitotic G1/S transition checkpoint (GO:0044819)2.23265481
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23115175
142positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.23102236
143regulation of chemokine secretion (GO:0090196)2.22970536
144protein localization to microtubule (GO:0035372)2.22265177
145activation of Rac GTPase activity (GO:0032863)2.22145754
146cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.21681914
147mitotic G1 DNA damage checkpoint (GO:0031571)2.21602854
148cellular response to gamma radiation (GO:0071480)2.19510997
149dendritic cell migration (GO:0036336)2.19469247
150regulation of heart rate by cardiac conduction (GO:0086091)2.19217939
151transferrin transport (GO:0033572)2.18332870
152regulation of female gonad development (GO:2000194)2.17943907
153positive regulation of cholesterol efflux (GO:0010875)2.16435788
154chemosensory behavior (GO:0007635)2.16015134
155sphingolipid catabolic process (GO:0030149)2.15643146
156eyelid development in camera-type eye (GO:0061029)2.14786144
157negative regulation of membrane potential (GO:0045837)2.14483911
158hydrogen peroxide biosynthetic process (GO:0050665)2.14318370
159purinergic nucleotide receptor signaling pathway (GO:0035590)2.13586877
160regulation of protein localization to cell surface (GO:2000008)2.13498178
161ionotropic glutamate receptor signaling pathway (GO:0035235)2.12995370
162granulocyte activation (GO:0036230)2.12739751
163positive regulation of mast cell activation (GO:0033005)2.12609911
164keratinization (GO:0031424)10.5917453
165* establishment of skin barrier (GO:0061436)10.4620973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.73988107
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07363186
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87909890
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49849989
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33188298
6ZNF263_19887448_ChIP-Seq_K562_Human2.27848391
7EZH2_22144423_ChIP-Seq_EOC_Human2.17359437
8* ATF3_27146783_Chip-Seq_COLON_Human2.16945452
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.10460784
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.07555201
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03343635
12GBX2_23144817_ChIP-Seq_PC3_Human2.03065563
13* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98477397
14TP63_22573176_ChIP-Seq_HFKS_Human1.94201086
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85222875
16RACK7_27058665_Chip-Seq_MCF-7_Human1.83753794
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82110643
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76181595
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75954472
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75055580
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73489224
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68955577
23P63_26484246_Chip-Seq_KERATINOCYTES_Human1.68045602
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67492144
25AR_21572438_ChIP-Seq_LNCaP_Human1.66784544
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.65199773
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63644354
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63233627
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.63025951
30TP53_18474530_ChIP-ChIP_U2OS_Human1.62798971
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62533857
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.61186798
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.60340787
34GATA3_24758297_ChIP-Seq_MCF-7_Human1.56888761
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.52950372
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52113616
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50587107
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48766062
39AHR_22903824_ChIP-Seq_MCF-7_Human1.46781076
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45787491
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.45073872
42RXR_22108803_ChIP-Seq_LS180_Human1.42790478
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.42649647
44* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42048064
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41976884
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41891279
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.41365672
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39723356
49SMAD4_21799915_ChIP-Seq_A2780_Human1.39625189
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39597888
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37653593
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.37542512
53AR_21909140_ChIP-Seq_LNCAP_Human1.37239975
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37130799
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37130799
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35545352
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31786694
58* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31175255
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30742361
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27657266
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26854057
62TP63_23658742_ChIP-Seq_EP156T_Human1.26527562
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.26505400
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.26480735
65DROSHA_22980978_ChIP-Seq_HELA_Human1.25693886
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25518860
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25518860
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25518860
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25435842
70VDR_22108803_ChIP-Seq_LS180_Human1.24404120
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24320489
72* GATA6_25053715_ChIP-Seq_YYC3_Human1.24141725
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.22862942
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.22770616
75CJUN_26792858_Chip-Seq_BT549_Human1.20739629
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.20671206
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.19931174
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19043004
79* P68_20966046_ChIP-Seq_HELA_Human1.18885776
80* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18631364
81* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18631364
82P300_19829295_ChIP-Seq_ESCs_Human1.18550419
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.18286234
84CTCF_20526341_ChIP-Seq_ESCs_Human1.18215550
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.18202517
86AR_25329375_ChIP-Seq_VCAP_Human1.18153390
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17455392
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.16674389
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16546049
90TP53_16413492_ChIP-PET_HCT116_Human1.16543215
91SMC4_20622854_ChIP-Seq_HELA_Human1.15991749
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.14682641
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14307156
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14075960
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13833670
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13496031
97* BCOR_27268052_Chip-Seq_Bcells_Human1.13213253
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12614769
99P53_22387025_ChIP-Seq_ESCs_Mouse1.12505838
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.12172315
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11279388
102RNF2_27304074_Chip-Seq_NSC_Mouse1.10927098
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.10249158
104E2F1_20622854_ChIP-Seq_HELA_Human1.10230927
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.09875061
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08935963
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08759598
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08506862
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.07187329
110PU1_27457419_Chip-Seq_LIVER_Mouse1.06925088
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.06187567
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06017967
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05830287
114TCF4_22108803_ChIP-Seq_LS180_Human1.05106258
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03757158
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03171741
117* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02816449
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02756232
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02674965
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02409802
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01513942
122CTCF_27219007_Chip-Seq_Bcells_Human1.00376385
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00302355
124REST_21632747_ChIP-Seq_MESCs_Mouse1.00044198
125GATA6_21074721_ChIP-Seq_CACO-2_Human1.00037622
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99677065
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97347364
128* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96889156
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96032211
130CTCF_18555785_Chip-Seq_ESCs_Mouse0.95893306
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.95759932
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95706871
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.95555653
134BCAT_22108803_ChIP-Seq_LS180_Human0.95462728
135CLOCK_20551151_ChIP-Seq_293T_Human0.94691202
136LXR_22292898_ChIP-Seq_THP-1_Human0.94074326
137SOX2_20726797_ChIP-Seq_SW620_Human0.93912264
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93586975
139* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93375016
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.92905247
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.92213432
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92148052
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91949056
144P300_18555785_Chip-Seq_ESCs_Mouse0.91683309
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91560676
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.91533861
147KLF4_18555785_Chip-Seq_ESCs_Mouse0.91263598
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90991535
149KLF5_25053715_ChIP-Seq_YYC3_Human0.90257515
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90145459
151ERG_20517297_ChIP-Seq_VCAP_Human0.88337089
152KDM2B_26808549_Chip-Seq_K562_Human0.87491710
153* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87259192
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.86970535
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86322430
156* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85824813
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85685757
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84634421
159ELF5_23300383_ChIP-Seq_T47D_Human0.83914697
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80418726
161* CHD1_26751641_Chip-Seq_LNCaP_Human0.80189232
162CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78108906
163* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77676900
164MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.77666027
165CREB1_26743006_Chip-Seq_LNCaP_Human0.76145861
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75019502
167GATA4_25053715_ChIP-Seq_YYC3_Human0.74220687
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72445616
169KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71810663
170EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70880666
171JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70691978
172AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70623503
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69658746
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.69254139
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.69254139
176FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69226204
177* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69065290
178PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69034436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.13376437
2MP0005275_abnormal_skin_tensile5.40446617
3MP0003941_abnormal_skin_development4.72037571
4MP0005501_abnormal_skin_physiology4.29694847
5MP0010234_abnormal_vibrissa_follicle3.54507847
6MP0005451_abnormal_body_composition3.42689768
7MP0002254_reproductive_system_inflammat3.39801448
8MP0000579_abnormal_nail_morphology3.10817156
9MP0002060_abnormal_skin_morphology2.93346568
10MP0001188_hyperpigmentation2.89714946
11MP0010771_integument_phenotype2.87393032
12MP0001216_abnormal_epidermal_layer2.87271147
13MP0004947_skin_inflammation2.62428304
14MP0004381_abnormal_hair_follicle2.53656042
15MP0000647_abnormal_sebaceous_gland2.31766512
16MP0003453_abnormal_keratinocyte_physiol2.27015577
17MP0000383_abnormal_hair_follicle2.19090803
18MP0002098_abnormal_vibrissa_morphology2.09594443
19MP0001346_abnormal_lacrimal_gland2.07188319
20MP0004782_abnormal_surfactant_physiolog1.92885556
21MP0010678_abnormal_skin_adnexa1.88874571
22MP0002148_abnormal_hypersensitivity_rea1.77841682
23MP0002234_abnormal_pharynx_morphology1.71736143
24MP0001984_abnormal_olfaction1.67746272
25MP0005646_abnormal_pituitary_gland1.66645831
26MP0003718_maternal_effect1.65685878
27MP0003880_abnormal_central_pattern1.63012465
28MP0000467_abnormal_esophagus_morphology1.62130195
29MP0000377_abnormal_hair_follicle1.58109754
30MP0001191_abnormal_skin_condition1.57728813
31MP0000427_abnormal_hair_cycle1.53996768
32MP0004859_abnormal_synaptic_plasticity1.48195995
33MP0005409_darkened_coat_color1.45388032
34MP0004264_abnormal_extraembryonic_tissu1.45185522
35MP0010386_abnormal_urinary_bladder1.41948574
36MP0009931_abnormal_skin_appearance1.41705768
37MP0003950_abnormal_plasma_membrane1.39661750
38MP0003878_abnormal_ear_physiology1.36599472
39MP0005377_hearing/vestibular/ear_phenot1.36599472
40MP0002009_preneoplasia1.32776822
41MP0000566_synostosis1.31098414
42MP0010352_gastrointestinal_tract_polyps1.29806344
43MP0009046_muscle_twitch1.27305026
44MP0004885_abnormal_endolymph1.27279230
45MP0000762_abnormal_tongue_morphology1.21448257
46MP0000367_abnormal_coat/_hair1.20774384
47MP0009764_decreased_sensitivity_to1.16200420
48MP0005310_abnormal_salivary_gland1.15991765
49MP0010030_abnormal_orbit_morphology1.15200619
50MP0000015_abnormal_ear_pigmentation1.12751714
51MP0005023_abnormal_wound_healing1.11495657
52MP0001501_abnormal_sleep_pattern1.11203112
53MP0008004_abnormal_stomach_pH1.10157796
54MP0001968_abnormal_touch/_nociception1.08142461
55MP0002277_abnormal_respiratory_mucosa1.06188669
56MP0003635_abnormal_synaptic_transmissio1.03957189
57MP0003566_abnormal_cell_adhesion1.02319382
58MP0005645_abnormal_hypothalamus_physiol1.01567691
59MP0003191_abnormal_cellular_cholesterol1.01311956
60MP0002095_abnormal_skin_pigmentation1.00820430
61MP0009785_altered_susceptibility_to1.00072952
62MP0001243_abnormal_dermal_layer0.99637820
63MP0002736_abnormal_nociception_after0.96719648
64MP0003436_decreased_susceptibility_to0.95096466
65MP0009745_abnormal_behavioral_response0.93529377
66MP0002063_abnormal_learning/memory/cond0.91852972
67MP0009053_abnormal_anal_canal0.90035362
68MP0001835_abnormal_antigen_presentation0.89861642
69MP0006292_abnormal_olfactory_placode0.89821959
70MP0009379_abnormal_foot_pigmentation0.89476249
71MP0004185_abnormal_adipocyte_glucose0.88038779
72MP0004742_abnormal_vestibular_system0.86328119
73MP0002876_abnormal_thyroid_physiology0.85708156
74MP0003705_abnormal_hypodermis_morpholog0.84942971
75MP0002177_abnormal_outer_ear0.81704987
76MP0002064_seizures0.78823437
77MP0005000_abnormal_immune_tolerance0.78057803
78MP0002572_abnormal_emotion/affect_behav0.76987490
79MP0004510_myositis0.76047346
80MP0000627_abnormal_mammary_gland0.75233153
81MP0001177_atelectasis0.74431347
82MP0009780_abnormal_chondrocyte_physiolo0.73660608
83MP0001784_abnormal_fluid_regulation0.73474887
84MP0000516_abnormal_urinary_system0.72071492
85MP0005367_renal/urinary_system_phenotyp0.72071492
86MP0002735_abnormal_chemical_nociception0.71447968
87MP0005499_abnormal_olfactory_system0.71444440
88MP0005394_taste/olfaction_phenotype0.71444440
89MP0002419_abnormal_innate_immunity0.70865383
90MP0005076_abnormal_cell_differentiation0.69903196
91MP0003724_increased_susceptibility_to0.68749508
92MP0000465_gastrointestinal_hemorrhage0.68019146
93MP0009840_abnormal_foam_cell0.66466817
94MP0001851_eye_inflammation0.65795771
95MP0005671_abnormal_response_to0.63419086
96MP0002006_tumorigenesis0.63118857
97MP0001440_abnormal_grooming_behavior0.62389607
98MP0005171_absent_coat_pigmentation0.61282567
99MP0005025_abnormal_response_to0.61189191
100MP0003136_yellow_coat_color0.60211929
101MP0000678_abnormal_parathyroid_gland0.59582248
102MP0002734_abnormal_mechanical_nocicepti0.59462732
103MP0003075_altered_response_to0.58998228
104MP0001502_abnormal_circadian_rhythm0.58578679
105MP0003011_delayed_dark_adaptation0.58351722
106MP0000613_abnormal_salivary_gland0.58227198
107MP0005174_abnormal_tail_pigmentation0.58210596
108MP0001340_abnormal_eyelid_morphology0.58003016
109MP0008789_abnormal_olfactory_epithelium0.56850266
110MP0004019_abnormal_vitamin_homeostasis0.56039527
111MP0001486_abnormal_startle_reflex0.55357774
112MP0000538_abnormal_urinary_bladder0.52504000
113MP0003828_pulmonary_edema0.52142817
114MP0004270_analgesia0.51662749
115MP0005387_immune_system_phenotype0.51291840
116MP0001790_abnormal_immune_system0.51291840
117MP0002557_abnormal_social/conspecific_i0.50565485
118MP0003755_abnormal_palate_morphology0.49509777
119MP0005395_other_phenotype0.49333604
120MP0008057_abnormal_DNA_replication0.47285833
121MP0002877_abnormal_melanocyte_morpholog0.46862434
122MP0009697_abnormal_copulation0.46506597
123MP0003699_abnormal_female_reproductive0.45696278
124MP0002138_abnormal_hepatobiliary_system0.45397638
125MP0004197_abnormal_fetal_growth/weight/0.43218936
126MP0008260_abnormal_autophagy0.42319859
127MP0003315_abnormal_perineum_morphology0.41047693
128MP0002111_abnormal_tail_morphology0.40233281
129MP0003693_abnormal_embryo_hatching0.35101929
130MP0002233_abnormal_nose_morphology0.33307106
131MP0000003_abnormal_adipose_tissue0.32689560
132MP0003890_abnormal_embryonic-extraembry0.32120241
133MP0005375_adipose_tissue_phenotype0.31130391
134MP0004233_abnormal_muscle_weight0.29127146
135MP0005666_abnormal_adipose_tissue0.28484239
136MP0005075_abnormal_melanosome_morpholog0.27921232
137MP0002697_abnormal_eye_size0.27772176
138MP0003879_abnormal_hair_cell0.27699635
139MP0002089_abnormal_postnatal_growth/wei0.27146788
140MP0000350_abnormal_cell_proliferation0.26700262
141MP0005647_abnormal_sex_gland0.24614663
142MP0001730_embryonic_growth_arrest0.24320701
143MP0000537_abnormal_urethra_morphology0.24269546
144MP0001881_abnormal_mammary_gland0.23523456
145MP0005621_abnormal_cell_physiology0.23002846
146MP0001672_abnormal_embryogenesis/_devel0.22722144
147MP0005380_embryogenesis_phenotype0.22722144
148MP0002210_abnormal_sex_determination0.21866348
149MP0000470_abnormal_stomach_morphology0.21820367
150MP0004957_abnormal_blastocyst_morpholog0.21606759
151MP0005257_abnormal_intraocular_pressure0.21136446
152MP0000428_abnormal_craniofacial_morphol0.20704421
153MP0006138_congestive_heart_failure0.20228283
154MP0000462_abnormal_digestive_system0.20013999
155MP0000733_abnormal_muscle_development0.19297065

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.95716419
2Palmoplantar hyperkeratosis (HP:0000972)5.88276975
3* Congenital ichthyosiform erythroderma (HP:0007431)5.84362298
4Palmar hyperkeratosis (HP:0010765)5.63909726
5Plantar hyperkeratosis (HP:0007556)5.62090976
6* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.54365597
7Erythroderma (HP:0001019)5.35190661
8Hypotrichosis (HP:0001006)5.27477098
9Abnormality of nail color (HP:0100643)5.03634515
10Thick nail (HP:0001805)4.83707016
11Erythema (HP:0010783)4.83101232
12Onycholysis (HP:0001806)4.67369856
13Lip pit (HP:0100267)4.52611397
14Right ventricular cardiomyopathy (HP:0011663)4.41384926
15Gangrene (HP:0100758)4.10566410
16Woolly hair (HP:0002224)4.09194818
17Ectropion (HP:0000656)4.08673537
18Conjunctival hamartoma (HP:0100780)4.05704699
19Eczematoid dermatitis (HP:0000976)3.96207896
20Abnormality of the salivary glands (HP:0010286)3.78622394
21Distal lower limb muscle weakness (HP:0009053)3.75491785
22Curly hair (HP:0002212)3.59667909
23Parakeratosis (HP:0001036)3.55883760
24Abnormal hair laboratory examination (HP:0003328)3.35553258
25Absent eyelashes (HP:0000561)3.25517054
26Fragile nails (HP:0001808)3.22731574
27Abnormal blistering of the skin (HP:0008066)3.22195736
28* Hypohidrosis (HP:0000966)3.12030627
29* Corneal erosion (HP:0200020)3.10676611
30Hamartoma of the eye (HP:0010568)2.95820750
31* Pruritus (HP:0000989)2.89779787
32Pili torti (HP:0003777)2.80113912
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77860796
34Focal motor seizures (HP:0011153)2.75204861
35Febrile seizures (HP:0002373)2.72383464
36Alopecia of scalp (HP:0002293)2.72062991
37Stenosis of the external auditory canal (HP:0000402)2.69877188
38Blepharitis (HP:0000498)2.66350765
39Hypergammaglobulinemia (HP:0010702)2.62633860
40Ridged nail (HP:0001807)2.59565373
41Milia (HP:0001056)2.58429880
42Selective tooth agenesis (HP:0001592)2.56332581
43* Palmoplantar keratoderma (HP:0000982)2.55823529
44Absent hair (HP:0002298)2.53520738
45Fatigable weakness (HP:0003473)2.52612116
46Abnormality of the neuromuscular junction (HP:0003398)2.52612116
47Amniotic constriction ring (HP:0009775)2.48045406
48Abnormality of placental membranes (HP:0011409)2.48045406
49Natal tooth (HP:0000695)2.47533656
50Hypoplastic labia majora (HP:0000059)2.45960618
51Sparse eyelashes (HP:0000653)2.42619711
52Nail dystrophy (HP:0008404)2.39007461
53Abnormality of the nasal septum (HP:0000419)2.37988513
54Fetal akinesia sequence (HP:0001989)2.33964703
55Popliteal pterygium (HP:0009756)2.33195236
56Sparse scalp hair (HP:0002209)2.31201043
57Advanced eruption of teeth (HP:0006288)2.29358839
58Recurrent abscess formation (HP:0002722)2.26732671
59Areflexia of lower limbs (HP:0002522)2.24790933
60Abnormality of the labia majora (HP:0012881)2.23454264
61Ventricular fibrillation (HP:0001663)2.23036826
62Stomach cancer (HP:0012126)2.18459431
63Septate vagina (HP:0001153)2.18068101
64Dehydration (HP:0001944)2.17270550
65Gingivitis (HP:0000230)2.14406014
66Recurrent bacterial skin infections (HP:0005406)2.13173826
67Nasolacrimal duct obstruction (HP:0000579)2.10211311
68Corneal dystrophy (HP:0001131)2.07666938
69Progressive cerebellar ataxia (HP:0002073)2.05974774
70Oligodontia (HP:0000677)2.02362789
71Hyperhidrosis (HP:0000975)1.98034114
72Mediastinal lymphadenopathy (HP:0100721)1.97894187
73Laryngomalacia (HP:0001601)1.97820413
74Prostate neoplasm (HP:0100787)1.96061777
75Abnormality of hair growth rate (HP:0011363)1.95785368
76Slow-growing hair (HP:0002217)1.95785368
77Furrowed tongue (HP:0000221)1.95223622
78Abnormality of secondary sexual hair (HP:0009888)1.92750936
79Abnormality of the axillary hair (HP:0100134)1.92750936
80Ventricular tachycardia (HP:0004756)1.91036825
81Optic neuritis (HP:0100653)1.90963576
82Retrobulbar optic neuritis (HP:0100654)1.90963576
83Upper limb muscle weakness (HP:0003484)1.90782098
84Ulnar claw (HP:0001178)1.88415691
85Autoamputation (HP:0001218)1.84678231
86Depressed nasal tip (HP:0000437)1.84052975
87Aplasia cutis congenita (HP:0001057)1.83856332
88Malignant hyperthermia (HP:0002047)1.83643950
89Melanocytic nevus (HP:0000995)1.83263438
90Skin pits (HP:0100276)1.82905096
91Hip dysplasia (HP:0001385)1.82900094
92Atonic seizures (HP:0010819)1.82425300
93Dry skin (HP:0000958)1.82132326
94Brittle hair (HP:0002299)1.80696513
95Anonychia (HP:0001798)1.79941715
96Hamartoma (HP:0010566)1.79789477
97Carious teeth (HP:0000670)1.79550394
98Abnormality of the dental root (HP:0006486)1.78169315
99Taurodontia (HP:0000679)1.78169315
100Abnormality of permanent molar morphology (HP:0011071)1.78169315
101Conical tooth (HP:0000698)1.78073832
102Sepsis (HP:0100806)1.76842326
103Submucous cleft hard palate (HP:0000176)1.75581950
104Obstructive lung disease (HP:0006536)1.75100796
105Chronic obstructive pulmonary disease (HP:0006510)1.75100796
106Orchitis (HP:0100796)1.75022707
107Optic nerve hypoplasia (HP:0000609)1.74825829
108Anhidrosis (HP:0000970)1.72990378
109Duplicated collecting system (HP:0000081)1.72560586
110Oral leukoplakia (HP:0002745)1.68211852
111Follicular hyperkeratosis (HP:0007502)1.66865013
112Aplasia/Hypoplasia of the fovea (HP:0008060)1.66357435
113Hypoplasia of the fovea (HP:0007750)1.66357435
114Mutism (HP:0002300)1.65311571
115Recurrent corneal erosions (HP:0000495)1.65305579
116Oligodactyly (hands) (HP:0001180)1.65204303
117Keratoconjunctivitis (HP:0001096)1.64397292
118Neonatal death (HP:0003811)1.64030635
119Breast hypoplasia (HP:0003187)1.63748485
120Abnormality of molar morphology (HP:0011070)1.62869784
121Abnormality of molar (HP:0011077)1.62869784
122Keratoconjunctivitis sicca (HP:0001097)1.62830944
123Septo-optic dysplasia (HP:0100842)1.61227624
124Asthma (HP:0002099)1.60716817
125Hypoplasia of dental enamel (HP:0006297)1.60251252
126Increased IgM level (HP:0003496)1.59414381
127Multifactorial inheritance (HP:0001426)1.58798873
128Premature loss of primary teeth (HP:0006323)1.58667850
129Hyporeflexia of lower limbs (HP:0002600)1.57682412
130Trismus (HP:0000211)1.57173329
131Congenital, generalized hypertrichosis (HP:0004540)1.57133119
132Abnormality of the lacrimal duct (HP:0011481)1.56993555
133Hydroureter (HP:0000072)1.56411812
134Hypodontia (HP:0000668)1.56307498
135Abnormality of the fingernails (HP:0001231)1.56296143
136Malnutrition (HP:0004395)1.55596250
137Severe Myopia (HP:0011003)1.54564588
138Pustule (HP:0200039)1.54308647
139Split foot (HP:0001839)1.54044775
140Amelogenesis imperfecta (HP:0000705)1.53190698
141Acanthosis nigricans (HP:0000956)1.53090657
142Abnormality of the dental pulp (HP:0006479)1.52493776
143Dry hair (HP:0011359)1.51514543
144Premature ovarian failure (HP:0008209)1.51459092
145Lack of skin elasticity (HP:0100679)1.51138512
146Fine hair (HP:0002213)1.50486084
147Atrophic scars (HP:0001075)1.48756705
148Non-midline cleft lip (HP:0100335)1.46454774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.14177879
2CASK3.31846806
3MAP3K143.31392140
4CDK123.27843928
5ARAF3.15156121
6MET2.96197929
7MST42.90002479
8EEF2K2.72697510
9IRAK32.60552511
10RIPK42.54062824
11MAP3K132.52543507
12TGFBR12.49530948
13ERBB32.36681911
14NTRK32.35343165
15MAP3K122.23641749
16PIK3CG2.21918938
17LATS22.11964607
18EPHA42.06121297
19PTK21.95726988
20BMPR21.94995623
21ADRBK21.91153789
22EPHA21.87773054
23TRIB31.86330991
24TAOK21.71515536
25ZAK1.65948626
26SIK11.64194920
27TNIK1.54586706
28PIM21.52578154
29MAP2K71.49186209
30NTRK21.46985972
31SMG11.45748158
32BCR1.44692605
33SIK31.44579507
34MOS1.44523462
35LATS11.43787705
36YES11.43258512
37MAPKAPK31.42023780
38NEK61.41266083
39FER1.41045349
40NME11.31857355
41ERN11.29732780
42AKT31.27788429
43BLK1.27480113
44KSR21.23259638
45FGFR11.20834071
46SGK21.20757150
47GRK71.20416024
48CDK91.19117498
49EPHB11.18696709
50MAP3K31.18573604
51EIF2AK31.16838022
52IRAK41.09132484
53INSRR1.08357968
54MAP2K61.07255850
55MARK11.07031516
56TTK1.05446328
57EPHB21.03531710
58TRPM71.02328604
59EIF2AK21.02263149
60CDK31.02183144
61MTOR1.01613474
62BRD40.99997536
63CDK70.99654081
64PBK0.97603477
65TXK0.95980641
66GRK10.95807437
67ICK0.94145494
68IKBKB0.93399475
69SGK30.90973572
70AURKA0.89959233
71MAP3K20.89365283
72LMTK20.88974425
73PLK20.88657349
74STK30.86870916
75MAP3K50.83757431
76MAP3K90.82123995
77FRK0.81334605
78GRK50.79169464
79STK38L0.78879578
80NUAK10.78395871
81PRKCE0.76771689
82MUSK0.76200405
83MAP2K40.75109509
84WNK10.74913950
85MAPKAPK50.74448886
86TESK10.73281437
87EPHA30.72980454
88STK380.72591735
89FGR0.72442664
90MST1R0.70492628
91MARK20.70026413
92NME20.67977623
93BMPR1B0.67927655
94PDGFRA0.67118322
95DMPK0.66320445
96NLK0.66199034
97MAPK130.66132495
98KSR10.65863186
99PRKD20.64372738
100MAP3K10.64172290
101TAOK30.62802728
102TYK20.61697948
103CHUK0.60789895
104SGK2230.60718742
105SGK4940.60718742
106NEK90.60704064
107PRKD30.60288911
108RIPK10.59379226
109RAF10.59072937
110ABL20.58933043
111MELK0.57406118
112CAMK2A0.57290944
113DYRK1A0.55487269
114TESK20.54379728
115MAP3K60.54318574
116IRAK20.53944978
117IRAK10.53115439
118LRRK20.52969608
119TAOK10.52805216
120PRKCG0.52659314
121PAK40.52385239
122EIF2AK10.51533255
123NTRK10.47753784
124RPS6KB10.47064605
125SGK10.46727136
126JAK10.45901387
127PINK10.45675863
128CAMK1D0.45032633
129DAPK20.43373682
130ERBB40.43295553
131MINK10.42223084
132PKN20.41902841
133MAP3K80.40513489
134ILK0.40506262
135ADRBK10.39919593
136MAP3K110.39764879
137IKBKE0.39594363
138MAP3K40.36605619
139SIK20.36446835
140MAPK150.35001496
141MAPKAPK20.34384126
142GSK3A0.34293962
143STK240.33715408
144TYRO30.33010225
145BRAF0.31765691
146CSNK1E0.29898480
147PRKCI0.28938293
148CDK50.28868717
149CHEK10.28422685
150MAPK110.28092781
151PKN10.27973060
152CDK80.27499008
153OBSCN0.26257887
154CSNK1A10.26004144
155RPS6KB20.25663000
156FGFR30.25471060
157PRKCD0.25456706
158AURKB0.25148077
159AKT20.23491742
160PDPK10.21752195
161FLT30.21139195
162MAP2K10.20611851

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049132.97469414
2Sphingolipid metabolism_Homo sapiens_hsa006002.20366311
3Nicotine addiction_Homo sapiens_hsa050332.13175936
4Graft-versus-host disease_Homo sapiens_hsa053322.09185283
5Collecting duct acid secretion_Homo sapiens_hsa049662.08672678
6Rheumatoid arthritis_Homo sapiens_hsa053232.05742930
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05004444
8p53 signaling pathway_Homo sapiens_hsa041151.84482252
9Synaptic vesicle cycle_Homo sapiens_hsa047211.82458064
10Fatty acid elongation_Homo sapiens_hsa000621.79561764
11Thyroid cancer_Homo sapiens_hsa052161.75453109
12Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.66559576
13Circadian entrainment_Homo sapiens_hsa047131.61020677
14Serotonergic synapse_Homo sapiens_hsa047261.58554925
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57767455
16Oocyte meiosis_Homo sapiens_hsa041141.54651025
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54120460
18Olfactory transduction_Homo sapiens_hsa047401.52137669
19Cell cycle_Homo sapiens_hsa041101.51272560
20Basal transcription factors_Homo sapiens_hsa030221.50251176
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41090517
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39547202
23Arachidonic acid metabolism_Homo sapiens_hsa005901.39236214
24Glutamatergic synapse_Homo sapiens_hsa047241.35661077
25GnRH signaling pathway_Homo sapiens_hsa049121.34619912
26Taste transduction_Homo sapiens_hsa047421.34490026
27Pertussis_Homo sapiens_hsa051331.33588866
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33045852
29Allograft rejection_Homo sapiens_hsa053301.32825426
30Amoebiasis_Homo sapiens_hsa051461.31423488
31Phototransduction_Homo sapiens_hsa047441.30862006
32Long-term depression_Homo sapiens_hsa047301.29337103
33Long-term potentiation_Homo sapiens_hsa047201.29074442
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28330126
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.28262205
36Tuberculosis_Homo sapiens_hsa051521.26238774
37Type I diabetes mellitus_Homo sapiens_hsa049401.24335585
38Phagosome_Homo sapiens_hsa041451.21242936
39Leishmaniasis_Homo sapiens_hsa051401.21126559
40Legionellosis_Homo sapiens_hsa051341.20204473
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.19459912
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18439329
43Salivary secretion_Homo sapiens_hsa049701.18391506
44Choline metabolism in cancer_Homo sapiens_hsa052311.18375429
45Morphine addiction_Homo sapiens_hsa050321.18165032
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14193252
47MicroRNAs in cancer_Homo sapiens_hsa052061.14008327
48Bladder cancer_Homo sapiens_hsa052191.11227520
49Gastric acid secretion_Homo sapiens_hsa049711.09705437
50ECM-receptor interaction_Homo sapiens_hsa045121.09381775
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09306801
52Small cell lung cancer_Homo sapiens_hsa052221.09149525
53TNF signaling pathway_Homo sapiens_hsa046681.08832740
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08506773
55Notch signaling pathway_Homo sapiens_hsa043301.08321472
56Vibrio cholerae infection_Homo sapiens_hsa051101.07865522
57Histidine metabolism_Homo sapiens_hsa003401.07797501
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05754030
59Calcium signaling pathway_Homo sapiens_hsa040201.04661929
60Renin secretion_Homo sapiens_hsa049241.04499662
61Asthma_Homo sapiens_hsa053101.04063503
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02899714
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02409921
64African trypanosomiasis_Homo sapiens_hsa051431.01598455
65GABAergic synapse_Homo sapiens_hsa047271.01359731
66Staphylococcus aureus infection_Homo sapiens_hsa051500.99467040
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99446338
68Hippo signaling pathway_Homo sapiens_hsa043900.99020309
69Salmonella infection_Homo sapiens_hsa051320.98930359
70Osteoclast differentiation_Homo sapiens_hsa043800.98296740
71Renal cell carcinoma_Homo sapiens_hsa052110.98113248
72ErbB signaling pathway_Homo sapiens_hsa040120.98108475
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97775823
74Glioma_Homo sapiens_hsa052140.97014999
75Ether lipid metabolism_Homo sapiens_hsa005650.96567013
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96338322
77Axon guidance_Homo sapiens_hsa043600.95921239
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94977866
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.94599399
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92755119
81Linoleic acid metabolism_Homo sapiens_hsa005910.92418694
82Acute myeloid leukemia_Homo sapiens_hsa052210.89772425
83Amphetamine addiction_Homo sapiens_hsa050310.88745571
84Oxytocin signaling pathway_Homo sapiens_hsa049210.87886377
85Malaria_Homo sapiens_hsa051440.87689494
86ABC transporters_Homo sapiens_hsa020100.87218572
87Cholinergic synapse_Homo sapiens_hsa047250.86615384
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86050518
89Circadian rhythm_Homo sapiens_hsa047100.84869878
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.82874603
91Endocytosis_Homo sapiens_hsa041440.80734900
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80161661
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.79726693
94Insulin signaling pathway_Homo sapiens_hsa049100.77587045
95Proteoglycans in cancer_Homo sapiens_hsa052050.77023254
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.76166541
97Autoimmune thyroid disease_Homo sapiens_hsa053200.75307419
98Dopaminergic synapse_Homo sapiens_hsa047280.74520911
99Chemokine signaling pathway_Homo sapiens_hsa040620.73397114
100Inositol phosphate metabolism_Homo sapiens_hsa005620.72875515
101Lysosome_Homo sapiens_hsa041420.71175215
102Insulin secretion_Homo sapiens_hsa049110.71010916
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70259149
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70137755
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69904435
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.69265135
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69051789
108Melanogenesis_Homo sapiens_hsa049160.68248689
109Endometrial cancer_Homo sapiens_hsa052130.68097153
110RNA transport_Homo sapiens_hsa030130.68051837
111Dorso-ventral axis formation_Homo sapiens_hsa043200.67936240
112Ras signaling pathway_Homo sapiens_hsa040140.67378139
113Influenza A_Homo sapiens_hsa051640.66885852
114mRNA surveillance pathway_Homo sapiens_hsa030150.66347140
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66069209
116Hepatitis C_Homo sapiens_hsa051600.65193199
117Mineral absorption_Homo sapiens_hsa049780.64959642
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.64879726
119Tight junction_Homo sapiens_hsa045300.64655046
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63287059
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.63146486
122Steroid biosynthesis_Homo sapiens_hsa001000.61327536
123Toxoplasmosis_Homo sapiens_hsa051450.60259231
124Estrogen signaling pathway_Homo sapiens_hsa049150.59668528
125Hematopoietic cell lineage_Homo sapiens_hsa046400.58901057
126MAPK signaling pathway_Homo sapiens_hsa040100.57203388
127Arginine biosynthesis_Homo sapiens_hsa002200.56444887
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55939089
129mTOR signaling pathway_Homo sapiens_hsa041500.55352486
130Measles_Homo sapiens_hsa051620.54826607
131Adherens junction_Homo sapiens_hsa045200.54207943
132Apoptosis_Homo sapiens_hsa042100.54106693
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53387945
134Pancreatic cancer_Homo sapiens_hsa052120.52548518
135cAMP signaling pathway_Homo sapiens_hsa040240.51978655
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51556615
137Phenylalanine metabolism_Homo sapiens_hsa003600.51213203
138Focal adhesion_Homo sapiens_hsa045100.50071538
139Arginine and proline metabolism_Homo sapiens_hsa003300.49923321
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49333125
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48627743
142FoxO signaling pathway_Homo sapiens_hsa040680.47944774
143Type II diabetes mellitus_Homo sapiens_hsa049300.47088465
144Pancreatic secretion_Homo sapiens_hsa049720.46666485
145VEGF signaling pathway_Homo sapiens_hsa043700.45664020
146AMPK signaling pathway_Homo sapiens_hsa041520.45178338
147Gap junction_Homo sapiens_hsa045400.44839818
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44623792
149Pathways in cancer_Homo sapiens_hsa052000.43582467
150Chronic myeloid leukemia_Homo sapiens_hsa052200.42797385
151Rap1 signaling pathway_Homo sapiens_hsa040150.39149425
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38995955
153Hedgehog signaling pathway_Homo sapiens_hsa043400.37682203
154TGF-beta signaling pathway_Homo sapiens_hsa043500.37480056
155Wnt signaling pathway_Homo sapiens_hsa043100.37343766
156Glucagon signaling pathway_Homo sapiens_hsa049220.35237289
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34746822
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34694946
159Non-small cell lung cancer_Homo sapiens_hsa052230.33990656

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