ALPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)7.85542705
2vitamin A metabolic process (GO:0006776)7.77095394
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.49802921
4epoxygenase P450 pathway (GO:0019373)6.46572883
5fat-soluble vitamin biosynthetic process (GO:0042362)6.40107804
6adhesion of symbiont to host cell (GO:0044650)6.32510532
7virion attachment to host cell (GO:0019062)6.32510532
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18283330
9flavonoid metabolic process (GO:0009812)6.09624973
10positive regulation of guanylate cyclase activity (GO:0031284)6.00233412
11phospholipid efflux (GO:0033700)5.98898145
12fructose metabolic process (GO:0006000)5.86379840
13urea metabolic process (GO:0019627)5.79918015
14actin filament depolymerization (GO:0030042)5.79418743
15digestive system process (GO:0022600)5.71787536
16regulation of cholesterol esterification (GO:0010872)5.67729198
17plasma lipoprotein particle assembly (GO:0034377)5.60828950
18positive regulation of triglyceride lipase activity (GO:0061365)5.59538961
19positive regulation of lipoprotein lipase activity (GO:0051006)5.59538961
20regulation of triglyceride catabolic process (GO:0010896)5.58058273
21drug catabolic process (GO:0042737)5.38334997
22protein-lipid complex assembly (GO:0065005)5.34289338
23nitrogen cycle metabolic process (GO:0071941)5.29881529
24hormone catabolic process (GO:0042447)5.29594584
25regulation of cellular extravasation (GO:0002691)5.20792599
26adhesion of symbiont to host (GO:0044406)5.17145739
27midgut development (GO:0007494)5.15056790
28cholesterol efflux (GO:0033344)5.12258754
29homocysteine metabolic process (GO:0050667)5.12039303
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.05725040
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.05725040
32very-low-density lipoprotein particle assembly (GO:0034379)4.94525915
33lipoprotein metabolic process (GO:0042157)4.92188236
34glucose 6-phosphate metabolic process (GO:0051156)4.85680899
35modified amino acid transport (GO:0072337)4.80947856
36drug metabolic process (GO:0017144)4.76426626
37regulation of cGMP biosynthetic process (GO:0030826)4.73445963
38antibacterial humoral response (GO:0019731)4.67018731
39purine nucleotide salvage (GO:0032261)4.66610063
40receptor guanylyl cyclase signaling pathway (GO:0007168)4.64883575
41antimicrobial humoral response (GO:0019730)4.57738205
42digestion (GO:0007586)4.53063823
43peptide hormone processing (GO:0016486)4.52864185
44lipoprotein transport (GO:0042953)4.49784003
45regulation of bile acid biosynthetic process (GO:0070857)4.45334946
46cellular response to nitric oxide (GO:0071732)4.40190454
47peptide catabolic process (GO:0043171)4.34818791
48oligosaccharide catabolic process (GO:0009313)4.34345561
49bundle of His cell to Purkinje myocyte communication (GO:0086069)4.32884350
50negative regulation of sterol transport (GO:0032372)4.32601788
51negative regulation of cholesterol transport (GO:0032375)4.32601788
52cellular response to hepatocyte growth factor stimulus (GO:0035729)4.31357670
53response to hepatocyte growth factor (GO:0035728)4.31357670
54sterol transport (GO:0015918)4.28407527
55cholesterol transport (GO:0030301)4.28407527
56diacylglycerol metabolic process (GO:0046339)4.26080814
57cholesterol homeostasis (GO:0042632)4.23838207
58drinking behavior (GO:0042756)4.23243554
59sterol homeostasis (GO:0055092)4.19396069
60sulfate transmembrane transport (GO:1902358)4.18458235
61reverse cholesterol transport (GO:0043691)4.13466115
62glycolipid catabolic process (GO:0019377)4.12137956
63positive regulation of fatty acid biosynthetic process (GO:0045723)4.11459235
64regulation of vitamin metabolic process (GO:0030656)4.10524810
65bile acid and bile salt transport (GO:0015721)4.06450785
66NADH metabolic process (GO:0006734)4.04310195
67glycosphingolipid catabolic process (GO:0046479)4.03598296
68positive regulation of pseudopodium assembly (GO:0031274)3.98710317
69arginine metabolic process (GO:0006525)3.95742811
70glutamine family amino acid biosynthetic process (GO:0009084)3.95641451
71regulation of cGMP metabolic process (GO:0030823)3.93834079
72renal system process involved in regulation of blood volume (GO:0001977)3.92616406
73cellular glucuronidation (GO:0052695)3.90547655
74response to nitric oxide (GO:0071731)3.86589257
75uronic acid metabolic process (GO:0006063)3.86326726
76glucuronate metabolic process (GO:0019585)3.86326726
77vitamin transmembrane transport (GO:0035461)3.85441926
78maintenance of gastrointestinal epithelium (GO:0030277)3.85096459
79UDP-N-acetylglucosamine metabolic process (GO:0006047)3.83811709
80cGMP-mediated signaling (GO:0019934)3.83718718
81citrulline metabolic process (GO:0000052)3.82713538
82bicarbonate transport (GO:0015701)3.80176447
83transepithelial transport (GO:0070633)3.73641513
84cellular response to reactive nitrogen species (GO:1902170)3.70591253
85protein-lipid complex remodeling (GO:0034368)3.69390748
86macromolecular complex remodeling (GO:0034367)3.69390748
87plasma lipoprotein particle remodeling (GO:0034369)3.69390748
88negative regulation of digestive system process (GO:0060457)3.69320342
89vitamin transport (GO:0051180)3.66766002
90citrulline biosynthetic process (GO:0019240)3.66115940
91alkaloid metabolic process (GO:0009820)3.63814619
92positive regulation of glycoprotein biosynthetic process (GO:0010560)3.63138649
93high-density lipoprotein particle remodeling (GO:0034375)3.62719332
94plasma lipoprotein particle organization (GO:0071827)3.58069651
95sperm capacitation (GO:0048240)3.57457456
96sulfation (GO:0051923)3.56256686
97regulation of pseudopodium assembly (GO:0031272)3.55753940
98protein-lipid complex subunit organization (GO:0071825)3.55740799
99sulfur compound transport (GO:0072348)3.50992649
100regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.50617971
101positive regulation of triglyceride metabolic process (GO:0090208)3.50571968
102nucleobase catabolic process (GO:0046113)3.49947861
103positive regulation of T cell differentiation in thymus (GO:0033089)3.47283222
104polyol transport (GO:0015791)3.44282637
105positive regulation of cGMP biosynthetic process (GO:0030828)3.42862687
106cellular carbohydrate catabolic process (GO:0044275)3.42749253
107fat-soluble vitamin metabolic process (GO:0006775)3.42092204
108response to hydroperoxide (GO:0033194)3.39630665
109regulation of lipoprotein metabolic process (GO:0050746)3.39321372
110phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.37304425
111sulfate transport (GO:0008272)3.37282932
112regulation of penile erection (GO:0060405)3.36367880
113regulation of digestive system process (GO:0044058)3.36341944
114negative regulation of thymocyte apoptotic process (GO:0070244)3.34441919
115mRNA modification (GO:0016556)3.33602829
116regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.31968465
117endocrine process (GO:0050886)3.31968465
118regulation of systemic arterial blood pressure by hormone (GO:0001990)3.31968465
119regulation of cholesterol homeostasis (GO:2000188)3.30043298
120nucleoside diphosphate biosynthetic process (GO:0009133)3.28768697
121mature B cell differentiation involved in immune response (GO:0002313)3.27762339
122auditory receptor cell differentiation (GO:0042491)3.26633032
123sexual reproduction (GO:0019953)3.23669821
124positive regulation of glycoprotein metabolic process (GO:1903020)3.23283402
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22300374
126intestinal epithelial cell development (GO:0060576)3.21344838
127ceramide catabolic process (GO:0046514)3.21196163
128cobalamin metabolic process (GO:0009235)3.19226299
129vitamin biosynthetic process (GO:0009110)3.19163135
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17433336
131regulation of cholesterol transport (GO:0032374)3.14146310
132regulation of sterol transport (GO:0032371)3.14146310
133protein kinase C signaling (GO:0070528)3.13562233
134positive regulation of lipid catabolic process (GO:0050996)3.12588337
135histamine secretion (GO:0001821)3.12261540
136cGMP biosynthetic process (GO:0006182)3.10474222
137regulation of Golgi to plasma membrane protein transport (GO:0042996)3.07888593
138exogenous drug catabolic process (GO:0042738)3.07348964
139sphingomyelin metabolic process (GO:0006684)3.07044629
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04879419
141phenylpropanoid metabolic process (GO:0009698)3.04620838
142transcytosis (GO:0045056)3.04437949
143neutral amino acid transport (GO:0015804)3.04041367
144glomerular filtration (GO:0003094)3.03492447
145thyroid hormone metabolic process (GO:0042403)3.02022768
146drug transport (GO:0015893)3.01975462
147Peyers patch development (GO:0048541)3.01791518
148mucosal-associated lymphoid tissue development (GO:0048537)3.01791518
149glycerol metabolic process (GO:0006071)3.00333327
150positive regulation of cGMP metabolic process (GO:0030825)2.99225492
151bile acid metabolic process (GO:0008206)2.98996281
152sphingolipid catabolic process (GO:0030149)2.98897459
153regulation of systemic arterial blood pressure (GO:0003073)2.95780126
154response to phenylpropanoid (GO:0080184)2.95390726
155regulation of actin nucleation (GO:0051125)2.94932247
156urea cycle (GO:0000050)2.93779161
157intestinal absorption (GO:0050892)13.1806263
158intestinal cholesterol absorption (GO:0030299)12.6730950
159angiotensin maturation (GO:0002003)11.3014682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.96175792
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.40263942
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.67276035
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.39405858
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.03147467
6GATA4_25053715_ChIP-Seq_YYC3_Human2.99592214
7* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.87544191
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86570905
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70592550
10GATA6_25053715_ChIP-Seq_YYC3_Human2.63717222
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.61751408
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.52911060
13SOX2_20726797_ChIP-Seq_SW620_Human2.52402854
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.36671753
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.35261318
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.29825047
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19005081
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13107409
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.11459825
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86541516
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75433318
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72496820
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72205900
24KLF5_25053715_ChIP-Seq_YYC3_Human1.70598235
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69288714
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.66519251
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.63437639
28GATA1_22025678_ChIP-Seq_K562_Human1.61738284
29* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59200062
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58997395
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58417693
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57279762
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55070867
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.54746913
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54078160
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51640040
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.43369492
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.41649472
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39757217
40GATA2_19941826_ChIP-Seq_K562_Human1.38763432
41RACK7_27058665_Chip-Seq_MCF-7_Human1.38544556
42SA1_27219007_Chip-Seq_Bcells_Human1.37863569
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.37284432
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.36738002
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36131351
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35234384
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33511664
48CLOCK_20551151_ChIP-Seq_293T_Human1.31015007
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30483050
50ATF3_27146783_Chip-Seq_COLON_Human1.29939484
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.26021077
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24269185
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23457670
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22951690
55JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21909394
56AR_21909140_ChIP-Seq_LNCAP_Human1.21236321
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.21165334
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20993702
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19203827
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16868190
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16601725
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15806576
63SMC4_20622854_ChIP-Seq_HELA_Human1.15218954
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14679564
65VDR_21846776_ChIP-Seq_THP-1_Human1.14292378
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09804426
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.09317923
68CREB1_26743006_Chip-Seq_LNCaP_Human1.08721259
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08678115
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07219411
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07036082
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.06972984
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06637089
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06510448
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05988513
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05208041
77* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04511970
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04451807
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04355524
80FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03516335
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.03498794
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03073121
83VDR_24763502_ChIP-Seq_THP-1_Human1.01969230
84VDR_22108803_ChIP-Seq_LS180_Human1.01863980
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01851743
86ETS1_21867929_ChIP-Seq_TH2_Mouse1.00306605
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00010695
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98870500
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98564537
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98187059
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96752186
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96457570
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95697827
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95547207
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.95278885
96P68_20966046_ChIP-Seq_HELA_Human0.95265098
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94963254
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94407441
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94347857
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93880244
101RXR_22108803_ChIP-Seq_LS180_Human0.93603397
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93556603
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.93210881
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93021263
105LXR_22292898_ChIP-Seq_THP-1_Human0.92737276
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92478572
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90695360
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.90224631
109CTCF_27219007_Chip-Seq_Bcells_Human0.88598945
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88350001
111STAT1_20625510_ChIP-Seq_HELA_Human0.88191453
112DROSHA_22980978_ChIP-Seq_HELA_Human0.85990901
113TP63_23658742_ChIP-Seq_EP156T_Human0.84737330
114GATA1_19941826_ChIP-Seq_K562_Human0.84619291
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.84111388
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82735348
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82585115
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82302653
119BCOR_27268052_Chip-Seq_Bcells_Human0.81375805
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80406308
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77570007
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77570007
123BCL6_27268052_Chip-Seq_Bcells_Human0.77364720
124EGR1_19032775_ChIP-ChIP_M12_Human0.77351642
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76872879
126ZNF263_19887448_ChIP-Seq_K562_Human0.75151283
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75104017
128TP63_22573176_ChIP-Seq_HFKS_Human0.74049714
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74009305
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.73687542
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73076960
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72687709
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71898484
134PHF8_20622854_ChIP-Seq_HELA_Human0.71350526
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70523256
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69165087
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69098783
138TP53_16413492_ChIP-PET_HCT116_Human0.68583764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.65627580
2MP0001666_abnormal_nutrient_absorption6.74095381
3MP0009840_abnormal_foam_cell4.37932592
4MP0002139_abnormal_hepatobiliary_system3.99254621
5MP0010234_abnormal_vibrissa_follicle3.92821064
6MP0003183_abnormal_peptide_metabolism3.84744057
7MP0003252_abnormal_bile_duct3.50652575
8MP0004264_abnormal_extraembryonic_tissu3.24627879
9MP0008875_abnormal_xenobiotic_pharmacok3.22588870
10MP0000462_abnormal_digestive_system3.12979430
11MP0005085_abnormal_gallbladder_physiolo3.06721520
12MP0003866_abnormal_defecation2.78082064
13MP0010329_abnormal_lipoprotein_level2.74839437
14MP0004147_increased_porphyrin_level2.33448180
15MP0004043_abnormal_pH_regulation2.30583515
16MP0005409_darkened_coat_color2.29257690
17MP0002822_catalepsy2.15053379
18MP0004019_abnormal_vitamin_homeostasis2.04436745
19MP0009697_abnormal_copulation1.92572149
20MP0005084_abnormal_gallbladder_morpholo1.91822412
21MP0005381_digestive/alimentary_phenotyp1.82211457
22MP0001663_abnormal_digestive_system1.81732478
23MP0000537_abnormal_urethra_morphology1.79068088
24MP0003300_gastrointestinal_ulcer1.74915723
25MP0003878_abnormal_ear_physiology1.71449718
26MP0005377_hearing/vestibular/ear_phenot1.71449718
27MP0004858_abnormal_nervous_system1.69779185
28MP0005365_abnormal_bile_salt1.67944254
29MP0010352_gastrointestinal_tract_polyps1.65035961
30MP0001664_abnormal_digestion1.63320315
31MP0003705_abnormal_hypodermis_morpholog1.54927507
32MP0003868_abnormal_feces_composition1.50752124
33MP0010155_abnormal_intestine_physiology1.49594419
34MP0000477_abnormal_intestine_morphology1.45387643
35MP0005670_abnormal_white_adipose1.43223738
36MP0001188_hyperpigmentation1.42155600
37MP0000538_abnormal_urinary_bladder1.41543675
38MP0005448_abnormal_energy_balance1.40776770
39MP0009780_abnormal_chondrocyte_physiolo1.40385203
40MP0001873_stomach_inflammation1.39604912
41MP0002254_reproductive_system_inflammat1.39142780
42MP0004782_abnormal_surfactant_physiolog1.35590517
43MP0002089_abnormal_postnatal_growth/wei1.32764129
44MP0006054_spinal_hemorrhage1.32198351
45MP0003191_abnormal_cellular_cholesterol1.29513003
46MP0000490_abnormal_crypts_of1.28956853
47MP0002796_impaired_skin_barrier1.28477418
48MP0009379_abnormal_foot_pigmentation1.21879690
49MP0002396_abnormal_hematopoietic_system1.11283809
50MP0002118_abnormal_lipid_homeostasis1.08730687
51MP0000467_abnormal_esophagus_morphology1.06140747
52MP0005332_abnormal_amino_acid0.99894794
53MP0003806_abnormal_nucleotide_metabolis0.98741768
54MP0000609_abnormal_liver_physiology0.97388498
55MP0001849_ear_inflammation0.97284896
56MP0009643_abnormal_urine_homeostasis0.97209270
57MP0003329_amyloid_beta_deposits0.96559028
58MP0001501_abnormal_sleep_pattern0.92739959
59MP0004270_analgesia0.92596526
60MP0001756_abnormal_urination0.88535502
61MP0005167_abnormal_blood-brain_barrier0.88235077
62MP0004947_skin_inflammation0.87496058
63MP0005266_abnormal_metabolism0.87325996
64MP0009053_abnormal_anal_canal0.86281763
65MP0005535_abnormal_body_temperature0.86044376
66MP0003718_maternal_effect0.83807791
67MP0003283_abnormal_digestive_organ0.83636164
68MP0001485_abnormal_pinna_reflex0.82490908
69MP0010678_abnormal_skin_adnexa0.81531652
70MP0001845_abnormal_inflammatory_respons0.79377986
71MP0008872_abnormal_physiological_respon0.79336490
72MP0002098_abnormal_vibrissa_morphology0.71526688
73MP0009384_cardiac_valve_regurgitation0.71511046
74MP0005501_abnormal_skin_physiology0.71339903
75MP0005367_renal/urinary_system_phenotyp0.71253826
76MP0000516_abnormal_urinary_system0.71253826
77MP0008469_abnormal_protein_level0.70602863
78MP0003436_decreased_susceptibility_to0.70411698
79MP0002166_altered_tumor_susceptibility0.68846066
80MP0000678_abnormal_parathyroid_gland0.65001772
81MP0002138_abnormal_hepatobiliary_system0.64943388
82MP0002896_abnormal_bone_mineralization0.64794878
83MP0005666_abnormal_adipose_tissue0.64670365
84MP0005319_abnormal_enzyme/_coenzyme0.63917466
85MP0005166_decreased_susceptibility_to0.62998951
86MP0001764_abnormal_homeostasis0.62135200
87MP0009765_abnormal_xenobiotic_induced0.61648819
88MP0009333_abnormal_splenocyte_physiolog0.60844296
89MP0009785_altered_susceptibility_to0.60724791
90MP0003950_abnormal_plasma_membrane0.60286769
91MP0001835_abnormal_antigen_presentation0.60275766
92MP0001765_abnormal_ion_homeostasis0.59805551
93MP0005451_abnormal_body_composition0.58081255
94MP0003453_abnormal_keratinocyte_physiol0.57711079
95MP0000013_abnormal_adipose_tissue0.57696948
96MP0000249_abnormal_blood_vessel0.56260045
97MP0005636_abnormal_mineral_homeostasis0.55885101
98MP0002136_abnormal_kidney_physiology0.55032679
99MP0005376_homeostasis/metabolism_phenot0.54517155
100MP0003879_abnormal_hair_cell0.53925946
101MP0003693_abnormal_embryo_hatching0.53603930
102MP0009642_abnormal_blood_homeostasis0.53520898
103MP0010307_abnormal_tumor_latency0.53032766
104MP0003724_increased_susceptibility_to0.51820927
105MP0005584_abnormal_enzyme/coenzyme_acti0.50355137
106MP0005058_abnormal_lysosome_morphology0.50176321
107MP0002876_abnormal_thyroid_physiology0.50163983
108MP0005025_abnormal_response_to0.49953304
109MP0001216_abnormal_epidermal_layer0.49740357
110MP0003638_abnormal_response/metabolism_0.49444099
111MP0009115_abnormal_fat_cell0.49072988
112MP0000465_gastrointestinal_hemorrhage0.47511086
113MP0005165_increased_susceptibility_to0.46951586
114MP0003953_abnormal_hormone_level0.46591567
115MP0000604_amyloidosis0.46269755
116MP0005387_immune_system_phenotype0.45817984
117MP0001790_abnormal_immune_system0.45817984
118MP0008004_abnormal_stomach_pH0.45299692
119MP0000681_abnormal_thyroid_gland0.43877844
120MP0003656_abnormal_erythrocyte_physiolo0.43534116
121MP0006138_congestive_heart_failure0.42434090
122MP0001881_abnormal_mammary_gland0.41746500
123MP0001191_abnormal_skin_condition0.41420935
124MP0000470_abnormal_stomach_morphology0.41054837
125MP0003119_abnormal_digestive_system0.40497612
126MP0008873_increased_physiological_sensi0.39540317
127MP0000230_abnormal_systemic_arterial0.39315574
128MP0000427_abnormal_hair_cycle0.38750061
129MP0003315_abnormal_perineum_morphology0.36337080
130MP0002078_abnormal_glucose_homeostasis0.35088215
131MP0002971_abnormal_brown_adipose0.34647635
132MP0000613_abnormal_salivary_gland0.34430464
133MP0000377_abnormal_hair_follicle0.31871631
134MP0003385_abnormal_body_wall0.31516246
135MP0000598_abnormal_liver_morphology0.30925937
136MP0005334_abnormal_fat_pad0.29382444

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.55573782
2Acanthocytosis (HP:0001927)7.66726673
3Hypobetalipoproteinemia (HP:0003563)7.65956881
4Autoimmune thrombocytopenia (HP:0001973)6.99393503
5Abnormality of glutamine family amino acid metabolism (HP:0010902)6.69483614
6Malnutrition (HP:0004395)6.32965507
7Abnormality of proline metabolism (HP:0010907)5.36255059
8Hydroxyprolinuria (HP:0003080)5.36255059
9Conjugated hyperbilirubinemia (HP:0002908)5.31410780
10Autoimmune hemolytic anemia (HP:0001890)5.27169412
11Cupped ribs (HP:0000887)5.13400776
12Right ventricular cardiomyopathy (HP:0011663)4.82045646
13Pigmentary retinal degeneration (HP:0001146)4.56464970
14Poikilocytosis (HP:0004447)4.55037699
15Hypolipoproteinemia (HP:0010981)4.46560524
16Increased IgE level (HP:0003212)4.29487297
17Widely patent fontanelles and sutures (HP:0004492)4.25021405
18Mesangial abnormality (HP:0001966)4.22045289
19Fat malabsorption (HP:0002630)4.07837520
20Systemic lupus erythematosus (HP:0002725)3.99650443
21Abnormality of B cell number (HP:0010975)3.69008329
22B lymphocytopenia (HP:0010976)3.69008329
23Facial shape deformation (HP:0011334)3.60826717
24Potter facies (HP:0002009)3.60826717
25Alkalosis (HP:0001948)3.60349526
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.53514675
27Abdominal distention (HP:0003270)3.51184000
28Severe combined immunodeficiency (HP:0004430)3.49639101
29Chronic diarrhea (HP:0002028)3.48761901
30Xanthomatosis (HP:0000991)3.34698813
31Hypercholesterolemia (HP:0003124)3.26185987
32Hyperglycinuria (HP:0003108)3.21013229
33Abnormality of pyrimidine metabolism (HP:0004353)3.18080620
34Glycosuria (HP:0003076)3.15243192
35Abnormality of urine glucose concentration (HP:0011016)3.15243192
36Hypoproteinemia (HP:0003075)3.15090787
37Gastrointestinal dysmotility (HP:0002579)3.13907020
38Thyroiditis (HP:0100646)3.13246457
39Combined immunodeficiency (HP:0005387)3.12964644
40Increased purine levels (HP:0004368)3.06718004
41Hyperuricemia (HP:0002149)3.06718004
42Increased mean platelet volume (HP:0011877)3.04024555
43Reticulocytosis (HP:0001923)2.99153499
44Dehydration (HP:0001944)2.95413332
45Wide cranial sutures (HP:0010537)2.82155347
46Abnormality of purine metabolism (HP:0004352)2.71565741
47Abnormal glucose tolerance (HP:0001952)2.71181522
48Decreased circulating renin level (HP:0003351)2.69085375
49Abnormal platelet volume (HP:0011876)2.67303459
50Metabolic alkalosis (HP:0200114)2.66915083
51Steatorrhea (HP:0002570)2.65963058
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62663184
53Nephrolithiasis (HP:0000787)2.62610305
54Epidermoid cyst (HP:0200040)2.60534453
55Posterior subcapsular cataract (HP:0007787)2.60393714
56Villous atrophy (HP:0011473)2.58952951
57Abnormality of small intestinal villus morphology (HP:0011472)2.58952951
58Focal segmental glomerulosclerosis (HP:0000097)2.57567932
59Hemorrhage of the eye (HP:0011885)2.56818661
60Polycythemia (HP:0001901)2.56142009
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.55455197
62Eczematoid dermatitis (HP:0000976)2.51459320
63Intrahepatic cholestasis (HP:0001406)2.49211488
64Abnormality of vitamin B metabolism (HP:0004340)2.37268149
65Hyperactive renin-angiotensin system (HP:0000841)2.36686322
66Rectal prolapse (HP:0002035)2.36257119
67Mildly elevated creatine phosphokinase (HP:0008180)2.34011028
68Abnormality of the gastric mucosa (HP:0004295)2.33567577
69Delayed epiphyseal ossification (HP:0002663)2.32385790
70Enlarged epiphyses (HP:0010580)2.30338053
71Gout (HP:0001997)2.29054568
72Hyperphosphaturia (HP:0003109)2.28016268
73Abnormal biliary tract morphology (HP:0012440)2.26944226
74Hypotension (HP:0002615)2.26576773
75Flat acetabular roof (HP:0003180)2.26172830
76Progressive sensorineural hearing impairment (HP:0000408)2.25615625
77Abnormality of the costochondral junction (HP:0000919)2.21885967
78Abnormality of eosinophils (HP:0001879)2.18797298
79Palpitations (HP:0001962)2.18518453
80Renal tubular acidosis (HP:0001947)2.13135685
81Eosinophilia (HP:0001880)2.12524691
82Abnormality of glycine metabolism (HP:0010895)2.11879574
83Abnormality of serine family amino acid metabolism (HP:0010894)2.11879574
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10854846
85Metabolic acidosis (HP:0001942)2.10244247
86Protuberant abdomen (HP:0001538)2.09881092
87Abnormality of vitamin metabolism (HP:0100508)2.08221718
88Irritability (HP:0000737)2.08083004
89Abnormality of nucleobase metabolism (HP:0010932)2.07222669
90Abnormality of renin-angiotensin system (HP:0000847)2.06098284
91Pili torti (HP:0003777)2.04478153
92Woolly hair (HP:0002224)2.02562145
93Nausea (HP:0002018)2.02294486
94Pustule (HP:0200039)2.01830478
95Hyperphosphatemia (HP:0002905)2.01197616
96Thin bony cortex (HP:0002753)2.00906574
97Congenital sensorineural hearing impairment (HP:0008527)1.99626108
98Gingivitis (HP:0000230)1.99233301
99Subcapsular cataract (HP:0000523)1.98576958
100Syncope (HP:0001279)1.98264833
101Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97725169
102Dicarboxylic aciduria (HP:0003215)1.97725169
103Abnormal gallbladder physiology (HP:0012438)1.96779801
104Cholecystitis (HP:0001082)1.96779801
105Symptomatic seizures (HP:0011145)1.96492017
106Impaired platelet aggregation (HP:0003540)1.96392122
107Abnormal platelet function (HP:0011869)1.96392122
108Polygenic inheritance (HP:0010982)1.95715935
109Hyperbilirubinemia (HP:0002904)1.93437191
110Abnormal urine phosphate concentration (HP:0012599)1.92728111
111Pancreatitis (HP:0001733)1.91954055
112Glomerulonephritis (HP:0000099)1.91535758
113Glomerulosclerosis (HP:0000096)1.91224237
114Cheilitis (HP:0100825)1.90512237
115Hyperparathyroidism (HP:0000843)1.89960508
116White forelock (HP:0002211)1.88629579
117Progressive hearing impairment (HP:0001730)1.88243151
118Abnormality of sulfur amino acid metabolism (HP:0004339)1.88232571
119Milia (HP:0001056)1.85190504
120Abnormality of complement system (HP:0005339)1.84617133
121Confusion (HP:0001289)1.84601690
122Abnormality of magnesium homeostasis (HP:0004921)1.83923905
123Granulocytopenia (HP:0001913)1.83854201
124Hypoalbuminemia (HP:0003073)1.81980469
125Abnormal albumin level (HP:0012116)1.81980469
126Growth hormone excess (HP:0000845)1.81354074
127Patchy hypopigmentation of hair (HP:0011365)1.78849959
128Cerebral palsy (HP:0100021)1.78363853
129Multiple lipomas (HP:0001012)1.77580314
130Abnormality of alkaline phosphatase activity (HP:0004379)1.75674386
131Nephritis (HP:0000123)1.74944306
132Lethargy (HP:0001254)1.74634536
133Abnormal enzyme/coenzyme activity (HP:0012379)1.74326730
134Myopathic facies (HP:0002058)1.73921227
135Hypophosphatemia (HP:0002148)1.73334401
136Abnormality of the 1st metacarpal (HP:0010009)1.70922080
137Vomiting (HP:0002013)1.70829773
138Proximal tubulopathy (HP:0000114)1.68950495
139Complement deficiency (HP:0004431)1.68454879
140Alopecia of scalp (HP:0002293)1.66742728
141Megaloblastic anemia (HP:0001889)1.64941407
142Segmental peripheral demyelination/remyelination (HP:0003481)1.63939724
143Abnormality of chloride homeostasis (HP:0011422)1.62760121
144Hyperammonemia (HP:0001987)1.61973845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.87335694
2FRK6.39427789
3LMTK25.38804266
4MST1R5.25499144
5MST44.82708967
6PRKG23.47054224
7NME13.31598290
8GRK63.19775284
9AKT33.07188447
10MAP3K22.69883824
11EPHA22.63626910
12RIPK12.48581879
13MAP3K102.46384902
14MAP2K22.41365025
15PTK62.08112563
16NUAK12.06203358
17MET1.93546641
18ERN11.86265365
19EPHB21.62728395
20EPHA31.61803746
21KSR21.49947361
22PIK3CA1.44934810
23DDR21.39168472
24STK391.29439011
25PRPF4B1.26675538
26TESK11.24407109
27TAOK11.16491571
28STK101.12877876
29MATK1.11364314
30OXSR11.09055221
31EPHB11.08918385
32TESK21.05799271
33PIM11.03326972
34BMX1.01963008
35MAP3K80.99383375
36STK240.97279962
37TAOK30.94914961
38LATS10.94707010
39PRKCI0.89448381
40PTK20.88718326
41RIPK40.88164861
42FER0.86037889
43MAP3K10.82344766
44FGFR30.82053518
45MAP3K70.81678227
46MAP2K10.78433286
47PRKAA20.75709769
48MAP3K120.75572993
49ERBB20.75089772
50SMG10.74226134
51TTK0.73718495
52MYLK0.73362223
53EPHA40.72603745
54NEK60.72442306
55PAK40.71680858
56TRIB30.71180642
57MAP3K110.68310321
58MAP2K60.66757435
59ICK0.66367408
60SCYL20.64134078
61PBK0.57562863
62TLK10.56593780
63NLK0.56217952
64BMPR20.56203981
65TBK10.54710403
66MAP3K90.52895525
67MAPK110.51893928
68IRAK10.51001630
69PRKCZ0.50359639
70PDPK10.48922460
71CSK0.40968826
72PRKAA10.40676909
73MTOR0.39847151
74MAP3K30.37534225
75TYRO30.35418388
76CAMK2G0.35217924
77TNIK0.35129978
78FGR0.34891852
79ABL20.33921310
80PDGFRA0.33536764
81PAK30.33377060
82MELK0.33143968
83CDK120.33061951
84JAK10.32566765
85LRRK20.32514649
86RPS6KA20.31680517
87ERBB40.30815873
88PDK10.30259757
89DYRK1B0.29949199
90CAMK2B0.28897141
91DMPK0.28822677
92MAP4K10.28645310
93MAP3K140.28309693
94CAMK2D0.28244314
95SRC0.28093436
96MAPK70.27533895
97PDK20.27328656
98PRKCA0.27193364
99STK30.26800656
100JAK20.25744799
101SIK10.25318523
102CSNK1A10.25148573
103TYK20.24676280
104FYN0.24398816
105PRKACG0.23597622
106IRAK30.23540988
107LIMK10.23183265
108PIM20.22137946
109RPS6KC10.22126074
110RPS6KL10.22126074
111MAPKAPK20.22118166
112CDK60.20319514
113PAK10.20078962
114AKT20.19907477
115RET0.19494177
116PKN20.19400894
117MAPK120.18816425
118PAK20.18709011
119INSRR0.18162485
120GRK10.17576256
121ROCK10.16975556
122CDK90.16882266
123ZAP700.16708379
124PRKCD0.16613520
125PRKACA0.16010690
126PRKCQ0.14108666
127CDK50.13527101
128GSK3A0.13507163
129STK110.13194141
130AURKB0.12130108
131FGFR40.11583032
132EEF2K0.11145605
133ITK0.11093578
134CDC42BPA0.10415223

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.22759613
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.08611808
3Mineral absorption_Homo sapiens_hsa049784.46637145
4Renin-angiotensin system_Homo sapiens_hsa046144.39013747
5Vitamin digestion and absorption_Homo sapiens_hsa049774.06765429
6Caffeine metabolism_Homo sapiens_hsa002323.36058148
7Galactose metabolism_Homo sapiens_hsa000523.18185310
8Carbohydrate digestion and absorption_Homo sapiens_hsa049733.02679141
9Starch and sucrose metabolism_Homo sapiens_hsa005002.98648994
10Sulfur metabolism_Homo sapiens_hsa009202.31869028
11Protein digestion and absorption_Homo sapiens_hsa049742.27183571
12Bile secretion_Homo sapiens_hsa049762.19639244
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.13534701
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13085628
15Fructose and mannose metabolism_Homo sapiens_hsa000511.90940951
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64747724
17Histidine metabolism_Homo sapiens_hsa003401.49579620
18Glycerolipid metabolism_Homo sapiens_hsa005611.28808757
19Glutathione metabolism_Homo sapiens_hsa004801.28539936
20PPAR signaling pathway_Homo sapiens_hsa033201.27933068
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25577173
22Sphingolipid metabolism_Homo sapiens_hsa006001.19522518
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17369001
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.15322851
25Arginine biosynthesis_Homo sapiens_hsa002201.15259508
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15048118
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12683258
28Asthma_Homo sapiens_hsa053101.11738982
29Nitrogen metabolism_Homo sapiens_hsa009101.08539305
30Tryptophan metabolism_Homo sapiens_hsa003801.06251447
31ABC transporters_Homo sapiens_hsa020101.03742675
32Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99642179
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98451131
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97019345
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94395727
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94276487
37Fatty acid degradation_Homo sapiens_hsa000710.90430540
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85304455
39Phenylalanine metabolism_Homo sapiens_hsa003600.85026023
40Autoimmune thyroid disease_Homo sapiens_hsa053200.79185525
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78239901
42Allograft rejection_Homo sapiens_hsa053300.76759861
43Arginine and proline metabolism_Homo sapiens_hsa003300.76556228
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.74160063
45Pentose phosphate pathway_Homo sapiens_hsa000300.72391163
46Graft-versus-host disease_Homo sapiens_hsa053320.69468212
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.66130686
48Chemical carcinogenesis_Homo sapiens_hsa052040.65121664
49Carbon metabolism_Homo sapiens_hsa012000.61647074
50Type II diabetes mellitus_Homo sapiens_hsa049300.60451383
51Staphylococcus aureus infection_Homo sapiens_hsa051500.59839670
52Tight junction_Homo sapiens_hsa045300.59725369
53Pyruvate metabolism_Homo sapiens_hsa006200.59003619
54Thyroid hormone synthesis_Homo sapiens_hsa049180.55410070
55Sulfur relay system_Homo sapiens_hsa041220.52669991
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51512243
57Other glycan degradation_Homo sapiens_hsa005110.51305916
58Retinol metabolism_Homo sapiens_hsa008300.49882883
59Type I diabetes mellitus_Homo sapiens_hsa049400.49279170
60Pancreatic secretion_Homo sapiens_hsa049720.48574119
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47980452
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45859544
63Thyroid cancer_Homo sapiens_hsa052160.42998835
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.40620429
65beta-Alanine metabolism_Homo sapiens_hsa004100.39428226
66Antigen processing and presentation_Homo sapiens_hsa046120.36909553
67Fatty acid biosynthesis_Homo sapiens_hsa000610.36761949
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36367527
69Gastric acid secretion_Homo sapiens_hsa049710.35720561
70Biosynthesis of amino acids_Homo sapiens_hsa012300.34219138
71Bladder cancer_Homo sapiens_hsa052190.31918368
72Glucagon signaling pathway_Homo sapiens_hsa049220.30863048
73Selenocompound metabolism_Homo sapiens_hsa004500.29507421
74Linoleic acid metabolism_Homo sapiens_hsa005910.29008684
75Arachidonic acid metabolism_Homo sapiens_hsa005900.27598328
76Fatty acid metabolism_Homo sapiens_hsa012120.27523740
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.26994371
78African trypanosomiasis_Homo sapiens_hsa051430.26401542
79Salmonella infection_Homo sapiens_hsa051320.25846712
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25675241
81Adherens junction_Homo sapiens_hsa045200.25249954
82Tyrosine metabolism_Homo sapiens_hsa003500.25024020
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.24520813
84Viral myocarditis_Homo sapiens_hsa054160.23761303
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23623167
86Salivary secretion_Homo sapiens_hsa049700.23579530
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22903515
88Peroxisome_Homo sapiens_hsa041460.22805732
89Hepatitis C_Homo sapiens_hsa051600.21550199
90Systemic lupus erythematosus_Homo sapiens_hsa053220.21426660
91Leishmaniasis_Homo sapiens_hsa051400.21256335
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20460111
93Insulin secretion_Homo sapiens_hsa049110.20375785
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.19353729
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.18376219
96* Metabolic pathways_Homo sapiens_hsa011000.18204978
97Renin secretion_Homo sapiens_hsa049240.18200366
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17863667
99Steroid biosynthesis_Homo sapiens_hsa001000.17544120
100GnRH signaling pathway_Homo sapiens_hsa049120.16939760
101Cocaine addiction_Homo sapiens_hsa050300.16266558
102Ether lipid metabolism_Homo sapiens_hsa005650.16116414
103Butanoate metabolism_Homo sapiens_hsa006500.15679873
104Lysine degradation_Homo sapiens_hsa003100.15029174
105Toxoplasmosis_Homo sapiens_hsa051450.14911739
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14540773
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14067559
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13170629
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12730200
110Pertussis_Homo sapiens_hsa051330.09806106
111Ovarian steroidogenesis_Homo sapiens_hsa049130.09744357
112Insulin resistance_Homo sapiens_hsa049310.07988801
113AMPK signaling pathway_Homo sapiens_hsa041520.07396604
114Gap junction_Homo sapiens_hsa045400.06889716
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06580348
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.05702650
117Vitamin B6 metabolism_Homo sapiens_hsa007500.05563564
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03969279
119Vibrio cholerae infection_Homo sapiens_hsa051100.03942393
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.02781925
121Long-term depression_Homo sapiens_hsa047300.02267800
122VEGF signaling pathway_Homo sapiens_hsa043700.01770285
123Inositol phosphate metabolism_Homo sapiens_hsa005620.00926055
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.00443373
125Hematopoietic cell lineage_Homo sapiens_hsa046400.00052589
126Influenza A_Homo sapiens_hsa05164-0.0111801
127Choline metabolism in cancer_Homo sapiens_hsa05231-0.0111102
128N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0095910
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0038118
130Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0011985

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