ALPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.79748843
2modulation by symbiont of host immune response (GO:0052553)5.79748843
3positive regulation by symbiont of host defense response (GO:0052509)5.79748843
4modulation by symbiont of host defense response (GO:0052031)5.79748843
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.79748843
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.79748843
7positive regulation of cellular amide metabolic process (GO:0034250)5.31811568
8negative regulation of cell killing (GO:0031342)4.34333608
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34333608
10response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.33702800
11response to host immune response (GO:0052572)4.33702800
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30293035
13T-helper 1 type immune response (GO:0042088)4.14670191
14macrophage activation involved in immune response (GO:0002281)4.12120701
15regulation of gamma-delta T cell activation (GO:0046643)4.07942150
16response to host (GO:0075136)4.01659346
17response to host defenses (GO:0052200)4.01659346
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01659346
19leukocyte aggregation (GO:0070486)3.98726341
20regulation of interferon-beta biosynthetic process (GO:0045357)3.82918830
21regulation of gamma-delta T cell differentiation (GO:0045586)3.78128696
22detection of molecule of bacterial origin (GO:0032490)3.62079477
23neutrophil mediated immunity (GO:0002446)3.61495364
24B cell receptor signaling pathway (GO:0050853)3.59858285
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.59432376
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.58253891
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58237883
28positive regulation of interferon-alpha production (GO:0032727)3.57992606
29microglial cell activation (GO:0001774)3.49732911
30response to pheromone (GO:0019236)3.47177223
31negative regulation of interleukin-12 production (GO:0032695)3.45005061
32response to peptidoglycan (GO:0032494)3.40440394
33response to muramyl dipeptide (GO:0032495)3.40328788
34neutrophil activation involved in immune response (GO:0002283)3.38339582
35detection of bacterium (GO:0016045)3.37084746
36positive regulation of gamma-delta T cell activation (GO:0046645)3.35578130
37positive regulation of heat generation (GO:0031652)3.35373405
38regulation of interferon-alpha production (GO:0032647)3.34734353
39I-kappaB phosphorylation (GO:0007252)3.34272730
40cAMP catabolic process (GO:0006198)3.33664153
41cytokine secretion (GO:0050663)3.23487574
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22933110
43positive regulation of interleukin-17 production (GO:0032740)3.19089306
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.18308356
45cellular response to ethanol (GO:0071361)3.17964372
46negative regulation of B cell mediated immunity (GO:0002713)3.17726998
47negative regulation of immunoglobulin mediated immune response (GO:0002890)3.17726998
48positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.16137082
49response to interleukin-15 (GO:0070672)3.12024211
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11637879
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10099672
52negative regulation of T cell mediated immunity (GO:0002710)3.07714236
53regulation of memory T cell differentiation (GO:0043380)3.07195724
54positive regulation of antigen processing and presentation (GO:0002579)3.06146613
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04862741
56cellular response to interleukin-15 (GO:0071350)3.04527909
57negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03801522
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02022437
59interferon-gamma-mediated signaling pathway (GO:0060333)3.01072418
60regulation of mast cell activation (GO:0033003)2.95550552
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.95484830
62cilium or flagellum-dependent cell motility (GO:0001539)2.95329674
63cyclic nucleotide catabolic process (GO:0009214)2.92092292
64negative regulation of adaptive immune response (GO:0002820)2.90439552
65macrophage activation (GO:0042116)2.90163500
66response to type I interferon (GO:0034340)2.89849627
67negative regulation of leukocyte mediated immunity (GO:0002704)2.89427878
68regulation of MHC class I biosynthetic process (GO:0045343)2.89217231
69granulocyte activation (GO:0036230)2.89022020
70leukocyte migration involved in inflammatory response (GO:0002523)2.87426547
71regulation of activation of Janus kinase activity (GO:0010533)2.87352180
72negative regulation of T-helper cell differentiation (GO:0045623)2.86690549
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86690549
74type I interferon signaling pathway (GO:0060337)2.85954287
75cellular response to type I interferon (GO:0071357)2.85954287
76regulation of interleukin-6 biosynthetic process (GO:0045408)2.85899402
77polyol transport (GO:0015791)2.84852864
78myeloid cell activation involved in immune response (GO:0002275)2.84673309
79regulation of interleukin-17 production (GO:0032660)2.84048279
80defense response to protozoan (GO:0042832)2.83810230
81regulation of cellular extravasation (GO:0002691)2.83293673
82lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82038770
83negative thymic T cell selection (GO:0045060)2.80759645
84neutrophil activation (GO:0042119)2.80251731
85positive regulation of interleukin-12 production (GO:0032735)2.78538089
86production of molecular mediator involved in inflammatory response (GO:0002532)2.77507686
87regulation of relaxation of muscle (GO:1901077)2.77272531
88negative T cell selection (GO:0043383)2.77119987
89myeloid leukocyte mediated immunity (GO:0002444)2.76271676
90regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.76161684
91regulation of alpha-beta T cell proliferation (GO:0046640)2.75438352
92activated T cell proliferation (GO:0050798)2.73556679
93NIK/NF-kappaB signaling (GO:0038061)2.73385997
94positive regulation of B cell differentiation (GO:0045579)2.73161860
95regulation of B cell differentiation (GO:0045577)2.72635932
96natural killer cell mediated cytotoxicity (GO:0042267)2.72440793
97natural killer cell mediated immunity (GO:0002228)2.72440793
98regulation of heat generation (GO:0031650)2.72238938
99superoxide anion generation (GO:0042554)2.71529318
100germinal center formation (GO:0002467)2.70225903
101positive regulation of natural killer cell activation (GO:0032816)2.70022578
102dendritic cell migration (GO:0036336)2.69977114
103response to interferon-alpha (GO:0035455)2.69136092
104regulation of T cell mediated cytotoxicity (GO:0001914)2.68927683
105detection of other organism (GO:0098543)2.68550339
106positive regulation of p38MAPK cascade (GO:1900745)2.68401480
107regulation of mast cell activation involved in immune response (GO:0033006)2.67866279
108positive regulation of mast cell activation (GO:0033005)2.67666227
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67208979
110positive thymic T cell selection (GO:0045059)2.66630052
111positive T cell selection (GO:0043368)2.66099097
112cellular extravasation (GO:0045123)2.64947604
113positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64747905
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64231063
115phosphatidylglycerol biosynthetic process (GO:0006655)2.64173293
116head development (GO:0060322)2.63901564
117detection of biotic stimulus (GO:0009595)2.63857756
118modulation by symbiont of host cellular process (GO:0044068)2.62193605
119positive regulation of granulocyte differentiation (GO:0030854)2.61530649
120regulation of antigen processing and presentation (GO:0002577)2.61339896
121detection of external biotic stimulus (GO:0098581)2.60918403
122B cell mediated immunity (GO:0019724)2.60660714
123negative regulation of lipid storage (GO:0010888)2.60544099
124regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60445582
125positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.60196960
126regulation of MHC class II biosynthetic process (GO:0045346)2.59928086
127interferon-gamma production (GO:0032609)2.59116099
128protein K11-linked deubiquitination (GO:0035871)2.58570706
129wound healing, spreading of cells (GO:0044319)2.58087319
130L-amino acid import (GO:0043092)2.54503444
131positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.53742839
132cell adhesion mediated by integrin (GO:0033627)2.53565483
133respiratory burst (GO:0045730)2.51182261
134wound healing, spreading of epidermal cells (GO:0035313)2.50821153
135regulation of cholesterol storage (GO:0010885)2.48984442
136cellular response to virus (GO:0098586)2.48725738
137positive regulation of interleukin-1 beta secretion (GO:0050718)2.48661750
138regulation of B cell receptor signaling pathway (GO:0050855)2.47644304
139dicarboxylic acid biosynthetic process (GO:0043650)2.47214433
140glycogen catabolic process (GO:0005980)2.46837347
141regulation of interleukin-1 beta secretion (GO:0050706)2.46260052
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45121316
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45121316
144cellular polysaccharide catabolic process (GO:0044247)2.43850748
145phospholipid homeostasis (GO:0055091)2.43758862
146positive regulation of toll-like receptor signaling pathway (GO:0034123)2.43288121
147positive regulation of interferon-beta production (GO:0032728)2.41771437
148immunoglobulin mediated immune response (GO:0016064)2.40596841
149glucan catabolic process (GO:0009251)2.40263170
150antigen processing and presentation of endogenous antigen (GO:0019883)2.39723891
151negative regulation of viral genome replication (GO:0045071)2.39168384
152positive regulation of natural killer cell differentiation (GO:0032825)2.39064510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.86084548
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.06212241
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64431673
4GATA1_22025678_ChIP-Seq_K562_Human3.49929175
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.23714687
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21233866
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.03386391
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83147675
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83010936
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.57767698
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32507783
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32250103
13SCL_19346495_ChIP-Seq_HPC-7_Human2.23778614
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21183289
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.20367412
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04181124
17VDR_24787735_ChIP-Seq_THP-1_Human1.99780174
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.98578968
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92312470
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87122019
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.83663916
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81816500
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72193595
24RXR_22108803_ChIP-Seq_LS180_Human1.71585630
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67659947
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57729424
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.55977441
28* GATA3_26560356_Chip-Seq_TH2_Human1.54607182
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54086537
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52380273
31ER_23166858_ChIP-Seq_MCF-7_Human1.51631703
32* GATA3_27048872_Chip-Seq_THYMUS_Human1.49235212
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49114754
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48760944
35VDR_22108803_ChIP-Seq_LS180_Human1.44156227
36ZNF274_21170338_ChIP-Seq_K562_Hela1.42197607
37RUNX_20019798_ChIP-Seq_JUKART_Human1.40712110
38SPI1_23127762_ChIP-Seq_K562_Human1.39841889
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38209287
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38209287
41SPI1_23547873_ChIP-Seq_NB4_Human1.37533631
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36668314
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.34957051
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33338515
45CJUN_26792858_Chip-Seq_BT549_Human1.32321660
46* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31916780
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31438274
48BCAT_22108803_ChIP-Seq_LS180_Human1.30771858
49DROSHA_22980978_ChIP-Seq_HELA_Human1.30552220
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.30062179
51STAT3_23295773_ChIP-Seq_U87_Human1.29948319
52SMRT_27268052_Chip-Seq_Bcells_Human1.26536436
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23976590
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22936493
55TP53_16413492_ChIP-PET_HCT116_Human1.22620279
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.21451296
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21170177
58IGF1R_20145208_ChIP-Seq_DFB_Human1.20899361
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20823225
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19329981
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18690464
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.18415761
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18334043
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17948773
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17021504
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16862429
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15661030
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15390098
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14430997
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13448301
71TCF4_23295773_ChIP-Seq_U87_Human1.12884579
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12462334
73PU_27001747_Chip-Seq_BMDM_Mouse1.11607639
74* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10919375
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10679215
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.09983904
77TP53_18474530_ChIP-ChIP_U2OS_Human1.09836222
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09796653
79BRD4_25478319_ChIP-Seq_HGPS_Human1.09137517
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08612147
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07845171
82SMAD4_21799915_ChIP-Seq_A2780_Human1.06705164
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05896868
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.05732686
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.04443602
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.02887932
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02855545
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02792630
89TAF15_26573619_Chip-Seq_HEK293_Human1.02558541
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01063615
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00081870
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99789759
93* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98507353
94* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98507353
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98229905
96VDR_24763502_ChIP-Seq_THP-1_Human0.97590093
97* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97551234
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.97284741
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96897615
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.96734325
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96580823
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95487205
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95095926
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94846216
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94790464
106CBP_20019798_ChIP-Seq_JUKART_Human0.94790464
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.94600540
108GBX2_23144817_ChIP-Seq_PC3_Human0.94553236
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.94239097
110OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93790912
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92860027
112* CDX2_22108803_ChIP-Seq_LS180_Human0.92626288
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.92165659
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92121286
115TP63_23658742_ChIP-Seq_EP156T_Human0.91840729
116SALL1_21062744_ChIP-ChIP_HESCs_Human0.91546072
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90906151
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90377099
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90209081
120AR_25329375_ChIP-Seq_VCAP_Human0.89618573
121* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88924863
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.88181216
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87703780
124P300_19829295_ChIP-Seq_ESCs_Human0.86649431
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.85384489
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85309695
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84902914
128GATA2_19941826_ChIP-Seq_K562_Human0.84786547
129MYB_26560356_Chip-Seq_TH1_Human0.84462439
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84363373
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82660245
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82493936
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82070449
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81367129
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80670329
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80187077
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.79861671
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79839556
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79146452
140AHR_22903824_ChIP-Seq_MCF-7_Human0.78678018
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78670252
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77077431
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.76607376
144MYB_26560356_Chip-Seq_TH2_Human0.76447383
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76411685
146AR_21572438_ChIP-Seq_LNCaP_Human0.76259167
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.75630976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.30741591
2MP0001835_abnormal_antigen_presentation3.42818152
3MP0003136_yellow_coat_color3.09569840
4MP0005058_abnormal_lysosome_morphology2.70684438
5MP0002419_abnormal_innate_immunity2.66550067
6MP0005387_immune_system_phenotype2.56719408
7MP0001790_abnormal_immune_system2.56719408
8MP0002254_reproductive_system_inflammat2.52604718
9MP0000015_abnormal_ear_pigmentation2.44621282
10MP0009785_altered_susceptibility_to2.40087888
11MP0001853_heart_inflammation2.30978157
12MP0003436_decreased_susceptibility_to2.24314474
13MP0000685_abnormal_immune_system2.22185256
14MP0003172_abnormal_lysosome_physiology2.21680808
15MP0002148_abnormal_hypersensitivity_rea2.11215398
16MP0005025_abnormal_response_to2.11106700
17MP0005670_abnormal_white_adipose2.10711466
18MP0008438_abnormal_cutaneous_collagen2.02992043
19MP0003303_peritoneal_inflammation2.02967060
20MP0005000_abnormal_immune_tolerance1.99576788
21MP0002452_abnormal_antigen_presenting1.94129738
22MP0003195_calcinosis1.93287619
23MP0003690_abnormal_glial_cell1.90011992
24MP0003763_abnormal_thymus_physiology1.89060207
25MP0003191_abnormal_cellular_cholesterol1.87353673
26MP0003724_increased_susceptibility_to1.85332282
27MP0001873_stomach_inflammation1.82491659
28MP0004381_abnormal_hair_follicle1.81269098
29MP0003075_altered_response_to1.79906673
30MP0005464_abnormal_platelet_physiology1.76498130
31MP0001800_abnormal_humoral_immune1.75426986
32MP0005166_decreased_susceptibility_to1.75039550
33MP0005409_darkened_coat_color1.71586109
34MP0003183_abnormal_peptide_metabolism1.66855314
35MP0005075_abnormal_melanosome_morpholog1.62831847
36MP0002723_abnormal_immune_serum1.62226494
37MP0009764_decreased_sensitivity_to1.60723477
38MP0004947_skin_inflammation1.55565437
39MP0009278_abnormal_bone_marrow1.52229816
40MP0001819_abnormal_immune_cell1.51712758
41MP0005671_abnormal_response_to1.51690861
42MP0003566_abnormal_cell_adhesion1.51122331
43MP0000465_gastrointestinal_hemorrhage1.51029025
44MP0005646_abnormal_pituitary_gland1.50587888
45MP0004858_abnormal_nervous_system1.50441058
46MP0008057_abnormal_DNA_replication1.50333892
47MP0003866_abnormal_defecation1.49257112
48MP0002420_abnormal_adaptive_immunity1.48743698
49MP0000371_diluted_coat_color1.48549031
50MP0002234_abnormal_pharynx_morphology1.45158229
51MP0004883_abnormal_blood_vessel1.44135370
52MP0000689_abnormal_spleen_morphology1.42316090
53MP0005174_abnormal_tail_pigmentation1.40985665
54MP0004510_myositis1.35536457
55MP0003300_gastrointestinal_ulcer1.34621261
56MP0001533_abnormal_skeleton_physiology1.33541956
57MP0005257_abnormal_intraocular_pressure1.33050812
58MP0002722_abnormal_immune_system1.30374924
59MP0001958_emphysema1.29370475
60MP0000372_irregular_coat_pigmentation1.28472674
61MP0000566_synostosis1.28230288
62MP0003045_fibrosis1.27485490
63MP0001346_abnormal_lacrimal_gland1.27148790
64MP0006082_CNS_inflammation1.26061438
65MP0002396_abnormal_hematopoietic_system1.25876763
66MP0005360_urolithiasis1.24658293
67MP0010155_abnormal_intestine_physiology1.21246249
68MP0001501_abnormal_sleep_pattern1.20965498
69MP0001845_abnormal_inflammatory_respons1.19589123
70MP0005164_abnormal_response_to1.18840235
71MP0003705_abnormal_hypodermis_morpholog1.18680314
72MP0004782_abnormal_surfactant_physiolog1.16149960
73MP0002132_abnormal_respiratory_system1.16041492
74MP0000343_altered_response_to1.13608421
75MP0003656_abnormal_erythrocyte_physiolo1.12576662
76MP0003091_abnormal_cell_migration1.10884345
77MP0008469_abnormal_protein_level1.10724266
78MP0003828_pulmonary_edema1.10515354
79MP0003448_altered_tumor_morphology1.10477124
80MP0002998_abnormal_bone_remodeling1.08189031
81MP0003646_muscle_fatigue1.07905410
82MP0009840_abnormal_foam_cell1.06992881
83MP0001986_abnormal_taste_sensitivity1.06598986
84MP0000703_abnormal_thymus_morphology1.05878763
85MP0002168_other_aberrant_phenotype1.04705143
86MP0000604_amyloidosis1.04665021
87MP0002277_abnormal_respiratory_mucosa1.01326428
88MP0002405_respiratory_system_inflammati0.99327536
89MP0005076_abnormal_cell_differentiation0.96870437
90MP0003252_abnormal_bile_duct0.96472394
91MP0004484_altered_response_of0.96057052
92MP0000716_abnormal_immune_system0.95790801
93MP0005310_abnormal_salivary_gland0.94190163
94MP0000427_abnormal_hair_cycle0.93947292
95MP0001293_anophthalmia0.92535700
96MP0004043_abnormal_pH_regulation0.91814448
97MP0002928_abnormal_bile_duct0.91165764
98MP0005377_hearing/vestibular/ear_phenot0.89172498
99MP0003878_abnormal_ear_physiology0.89172498
100MP0002138_abnormal_hepatobiliary_system0.89053217
101MP0005397_hematopoietic_system_phenotyp0.88107427
102MP0001545_abnormal_hematopoietic_system0.88107427
103MP0001851_eye_inflammation0.87940645
104MP0002177_abnormal_outer_ear0.86938927
105MP0005197_abnormal_uvea_morphology0.85355797
106MP0005171_absent_coat_pigmentation0.83118064
107MP0002095_abnormal_skin_pigmentation0.81755743
108MP0004130_abnormal_muscle_cell0.81699883
109MP0010329_abnormal_lipoprotein_level0.81206749
110MP0001915_intracranial_hemorrhage0.80840407
111MP0006054_spinal_hemorrhage0.80590293
112MP0003943_abnormal_hepatobiliary_system0.80202640
113MP0002089_abnormal_postnatal_growth/wei0.79446176
114MP0002398_abnormal_bone_marrow0.79399371
115MP0000767_abnormal_smooth_muscle0.78316337
116MP0009763_increased_sensitivity_to0.77938913
117MP0002166_altered_tumor_susceptibility0.75433102
118MP0002332_abnormal_exercise_endurance0.74813782
119MP0002006_tumorigenesis0.74006929
120MP0001299_abnormal_eye_distance/0.73992585
121MP0002693_abnormal_pancreas_physiology0.73659774
122MP0005167_abnormal_blood-brain_barrier0.72740483
123MP0001663_abnormal_digestive_system0.72159323
124MP0002933_joint_inflammation0.72132766
125MP0004808_abnormal_hematopoietic_stem0.71777925
126MP0005376_homeostasis/metabolism_phenot0.71777362
127MP0005390_skeleton_phenotype0.71726154
128MP0008260_abnormal_autophagy0.70864248
129MP0002429_abnormal_blood_cell0.70762243
130MP0001324_abnormal_eye_pigmentation0.68256554
131MP0000249_abnormal_blood_vessel0.67929723
132MP0009115_abnormal_fat_cell0.67429165
133MP0005085_abnormal_gallbladder_physiolo0.65327316
134MP0009765_abnormal_xenobiotic_induced0.63060696
135MP0000470_abnormal_stomach_morphology0.60140625
136MP0000383_abnormal_hair_follicle0.59098104
137MP0000230_abnormal_systemic_arterial0.58136532

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.44791598
2Recurrent bacterial skin infections (HP:0005406)4.41948962
3Recurrent gram-negative bacterial infections (HP:0005420)4.33011095
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.13243894
5Autoimmune thrombocytopenia (HP:0001973)4.08571894
6Eczematoid dermatitis (HP:0000976)4.06411275
7Prostate neoplasm (HP:0100787)3.84058041
8Mediastinal lymphadenopathy (HP:0100721)3.65947362
9Spinal cord lesions (HP:0100561)3.48262242
10Syringomyelia (HP:0003396)3.48262242
11Gingivitis (HP:0000230)3.37014308
12Abnormality of T cell number (HP:0011839)3.30031077
13Abnormality of macrophages (HP:0004311)3.27256401
14Gastrointestinal infarctions (HP:0005244)3.24451656
15Retrobulbar optic neuritis (HP:0100654)3.23567274
16Optic neuritis (HP:0100653)3.23567274
17Orchitis (HP:0100796)3.19352283
18Periodontitis (HP:0000704)3.04446249
19Encephalitis (HP:0002383)3.03515419
20Meningitis (HP:0001287)2.99817023
21T lymphocytopenia (HP:0005403)2.98517804
22Genetic anticipation (HP:0003743)2.96132795
23Hypoplasia of the fovea (HP:0007750)2.90908013
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.90908013
25Myositis (HP:0100614)2.90881872
26Spontaneous hematomas (HP:0007420)2.87869845
27Stomach cancer (HP:0012126)2.87843058
28Abnormality of T cells (HP:0002843)2.83549974
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.79491915
30Alopecia of scalp (HP:0002293)2.78710423
31Abnormality of T cell physiology (HP:0011840)2.78062293
32Elevated erythrocyte sedimentation rate (HP:0003565)2.76843228
33Tetraparesis (HP:0002273)2.75433536
34Aplasia/Hypoplasia of the macula (HP:0008059)2.71827214
35Hypochromic microcytic anemia (HP:0004840)2.70046239
36Systemic lupus erythematosus (HP:0002725)2.70015096
37Myocardial infarction (HP:0001658)2.68876244
38Recurrent bronchitis (HP:0002837)2.64693098
39Recurrent skin infections (HP:0001581)2.64279797
40Tubulointerstitial nephritis (HP:0001970)2.63986342
41Hypoglycemic seizures (HP:0002173)2.61587422
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60951302
43Inflammation of the large intestine (HP:0002037)2.57130031
44Vasculitis (HP:0002633)2.54716248
45Leukocytosis (HP:0001974)2.52796373
46Hypochromic anemia (HP:0001931)2.51730336
47Obstructive lung disease (HP:0006536)2.50909637
48Chronic obstructive pulmonary disease (HP:0006510)2.50909637
49Gaze-evoked nystagmus (HP:0000640)2.48567817
50Chest pain (HP:0100749)2.47819523
51Prolonged bleeding time (HP:0003010)2.47411475
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.46808324
53Absent/shortened dynein arms (HP:0200106)2.46808324
54Panhypogammaglobulinemia (HP:0003139)2.45464232
55Autoimmune hemolytic anemia (HP:0001890)2.45330005
56Eosinophilia (HP:0001880)2.42170312
57Hyperventilation (HP:0002883)2.40770117
58Urticaria (HP:0001025)2.40634403
59Ectropion (HP:0000656)2.40596719
60Recurrent fungal infections (HP:0002841)2.40147213
61Renal cortical cysts (HP:0000803)2.39156182
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.37115890
63Thick nail (HP:0001805)2.37079722
64Chronic diarrhea (HP:0002028)2.35570898
65Pulmonary infiltrates (HP:0002113)2.35419388
66Absent frontal sinuses (HP:0002688)2.33916158
67Gingival bleeding (HP:0000225)2.33150249
68Abnormality of B cell number (HP:0010975)2.30247733
69Pancreatic cysts (HP:0001737)2.28452689
70Recurrent sinusitis (HP:0011108)2.26256443
71Congenital stationary night blindness (HP:0007642)2.25734051
72Poor head control (HP:0002421)2.25563047
73Pulmonary embolism (HP:0002204)2.25089589
74Attenuation of retinal blood vessels (HP:0007843)2.24843068
75Gastrointestinal inflammation (HP:0004386)2.24495042
76Bone pain (HP:0002653)2.22292532
77Congenital sensorineural hearing impairment (HP:0008527)2.20568467
78Increased IgE level (HP:0003212)2.18987718
79Granulocytopenia (HP:0001913)2.17872378
80Chronic otitis media (HP:0000389)2.17371643
81Aplasia cutis congenita (HP:0001057)2.17249902
82Episodic fever (HP:0001954)2.16625578
83Abnormality of eosinophils (HP:0001879)2.15420220
84Epistaxis (HP:0000421)2.15136559
85Stomatitis (HP:0010280)2.13054222
86Premature loss of primary teeth (HP:0006323)2.12893560
87Progressive cerebellar ataxia (HP:0002073)2.12880748
88Abnormality of the pleura (HP:0002103)2.11703084
89Recurrent pneumonia (HP:0006532)2.11547538
90Pustule (HP:0200039)2.10486967
91Abnormality of the prostate (HP:0008775)2.08980686
92Recurrent viral infections (HP:0004429)2.08240133
93Abnormal ciliary motility (HP:0012262)2.08190205
94Thyroiditis (HP:0100646)2.07989056
95Abnormality of primary teeth (HP:0006481)2.07927546
96Osteomyelitis (HP:0002754)2.07429202
97Anorexia (HP:0002039)2.06661013
98Arterial thrombosis (HP:0004420)2.06467023
99Gangrene (HP:0100758)2.04496628
100Abnormality of the lumbar spine (HP:0100712)2.04338386
101Basal ganglia calcification (HP:0002135)2.03902249
102Abnormality of the fovea (HP:0000493)2.03550800
103Symptomatic seizures (HP:0011145)2.02188467
104Microvesicular hepatic steatosis (HP:0001414)2.01983852
105Facial diplegia (HP:0001349)2.01685475
106Colitis (HP:0002583)1.99298806
107Widely spaced teeth (HP:0000687)1.98649148
108Vacuolated lymphocytes (HP:0001922)1.98514770
109Clumsiness (HP:0002312)1.97845620
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96846936
111Abnormality of the renal cortex (HP:0011035)1.96637048
112Albinism (HP:0001022)1.95913302
113Abnormality of polysaccharide metabolism (HP:0011012)1.94931100
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94931100
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94931100
116Joint hemorrhage (HP:0005261)1.93997875
117Abnormal rod and cone electroretinograms (HP:0008323)1.92587740
118Hemoptysis (HP:0002105)1.91384706
119Narrow palate (HP:0000189)1.91217187
120Keratitis (HP:0000491)1.90994642
121Keratoconjunctivitis sicca (HP:0001097)1.90432930
122Decreased circulating renin level (HP:0003351)1.89536365
123Increased cerebral lipofuscin (HP:0011813)1.89528912
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89356047
125Fair hair (HP:0002286)1.88477785
126Macular degeneration (HP:0000608)1.87844916
127Bronchiectasis (HP:0002110)1.86971940
128Skull defect (HP:0001362)1.86902320
129Cellulitis (HP:0100658)1.86714040
130Bronchitis (HP:0012387)1.85906582
131Turricephaly (HP:0000262)1.85495799
132Lymphopenia (HP:0001888)1.85269081
133Nephritis (HP:0000123)1.84683902
134Chronic sinusitis (HP:0011109)1.84442600
135Hematochezia (HP:0002573)1.83517564
136Enlarged kidneys (HP:0000105)1.82841314
137Axonal loss (HP:0003447)1.82187737
138Chronic mucocutaneous candidiasis (HP:0002728)1.81475022
139Recurrent cutaneous fungal infections (HP:0011370)1.81475022
140Short nail (HP:0001799)1.78532474
141Recurrent lower respiratory tract infections (HP:0002783)1.78159272
142Amyloidosis (HP:0011034)1.77615603
143Abnormality of the renal collecting system (HP:0004742)1.77335664
144Mucopolysacchariduria (HP:0008155)1.76926386
145Urinary glycosaminoglycan excretion (HP:0003541)1.76926386
146Abnormality of incisor morphology (HP:0011063)1.76581970
147Keratoconjunctivitis (HP:0001096)1.76578847
148Osteolytic defects of the hand bones (HP:0009699)1.74810910
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.74810910
150Hyperlipoproteinemia (HP:0010980)1.73470223
151Conical tooth (HP:0000698)1.73015310
152Long toe (HP:0010511)1.72961422
153Restrictive lung disease (HP:0002091)1.72185557
154Follicular hyperkeratosis (HP:0007502)1.72150780
155Femoral bowing (HP:0002980)1.71968903
156Mitral stenosis (HP:0001718)1.70432746
157Pathologic fracture (HP:0002756)1.69509110
158Hydroxyprolinuria (HP:0003080)1.68833020
159Abnormality of proline metabolism (HP:0010907)1.68833020
160Tetany (HP:0001281)1.67657481
161Glomerulonephritis (HP:0000099)1.65406168
162Cupped ear (HP:0000378)1.64931184
163Peritonitis (HP:0002586)1.62335672
164Ulnar bowing (HP:0003031)1.61629302
165Distal lower limb amyotrophy (HP:0008944)1.60413558
166Hypoglycemic coma (HP:0001325)1.60004530
167Radial bowing (HP:0002986)1.59282893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.07967983
2STK103.97810530
3MARK33.84233946
4TYK23.37759005
5IRAK33.17566038
6PRKD32.74625827
7MAP3K132.48243032
8JAK12.34917125
9RIPK42.34681447
10JAK32.33520183
11TNK22.11304271
12ACVR1B2.10134245
13MAPK131.92058152
14SIK31.90293677
15MAP2K31.89528622
16IRAK41.86397485
17IKBKB1.67346769
18IKBKE1.64012128
19KIT1.63281752
20IRAK11.61550160
21TBK11.61446185
22TAOK31.59507327
23CAMK1D1.54250888
24CHUK1.53994537
25GRK61.52973803
26SIK11.51001913
27LATS11.47327634
28EIF2AK21.46384599
29TTN1.44898485
30BMPR1B1.44025726
31CDK121.43910812
32TXK1.43562603
33SIK21.43448641
34TNIK1.42295601
35PIM11.40660410
36TAOK21.31082340
37PTK2B1.26957687
38ADRBK21.24480268
39FES1.22923570
40NUAK11.22285706
41EPHA31.20390553
42CASK1.18096199
43RIPK11.12038880
44NLK1.10630363
45PIK3CA1.05235893
46HCK1.04907895
47MAP4K11.03929180
48MAP3K31.02866292
49DAPK21.02007926
50CDK81.00557228
51ERN10.99437624
52STK380.99283554
53FGR0.98848523
54BLK0.97705296
55PRPF4B0.97485140
56CAMK1G0.96648582
57BRD40.94639231
58EPHB10.93328256
59PTK60.92067469
60STK30.90817383
61SGK30.90767777
62TRPM70.90340947
63OXSR10.89004110
64NEK90.87845807
65YES10.86945672
66TGFBR20.86546542
67TIE10.86061349
68INSRR0.85654337
69ADRBK10.85250773
70MATK0.85059131
71PRKCH0.84455268
72SGK20.84023968
73FGFR30.83340576
74PDK10.82846000
75MAP3K60.82077378
76AKT30.79989446
77CSK0.79567292
78MAP2K60.76817026
79CSF1R0.76152403
80BTK0.74482736
81MAP3K20.72685456
82FRK0.72405739
83MAP4K20.72275219
84MST1R0.71033731
85JAK20.70509272
86CLK10.69518782
87SYK0.68427074
88TEC0.67679411
89ABL10.66010168
90FER0.65950686
91MAPK110.64925343
92CAMKK20.64046904
93HIPK20.63399353
94LCK0.62792609
95FGFR40.61985644
96LYN0.61484074
97MARK20.60207140
98GRK10.59305517
99ZAK0.58886877
100PAK30.58346248
101STK240.56411750
102WNK10.55729277
103GRK70.54421801
104PRKCD0.54172088
105TAOK10.52438990
106STK110.52316396
107PDPK10.51723525
108MAP3K10.50743962
109CDC42BPA0.50512166
110PRKAA20.50476456
111BMX0.49580131
112CDK60.47688180
113STK38L0.47612666
114NEK60.46309019
115EGFR0.45774861
116PDGFRB0.45279253
117PIK3CG0.44347338
118PRKCE0.44090183
119MAP3K70.43527239
120SRC0.42217607
121CDK30.41094420
122IRAK20.40906782
123SGK10.39684834
124PRKD20.39647201
125MAP2K40.38502172
126MAP3K50.38326396
127ERBB20.37630911
128RPS6KA60.37331149
129BMPR20.37262799
130PKN10.36470025
131ZAP700.36353859
132MAPK70.36349410
133FYN0.33755813
134SGK2230.33366810
135SGK4940.33366810
136MELK0.33306793
137TGFBR10.32493566
138PLK20.31299902
139AKT10.28727463
140ITK0.28723059
141KSR10.28516056
142PRKCQ0.27561210
143ABL20.27438344

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.48607795
2Autoimmune thyroid disease_Homo sapiens_hsa053202.39963650
3Staphylococcus aureus infection_Homo sapiens_hsa051502.25849246
4Leishmaniasis_Homo sapiens_hsa051402.11712894
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08060966
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.07547744
7Type I diabetes mellitus_Homo sapiens_hsa049401.99451916
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92632157
9Malaria_Homo sapiens_hsa051441.90238584
10Primary immunodeficiency_Homo sapiens_hsa053401.82005990
11Osteoclast differentiation_Homo sapiens_hsa043801.80442055
12African trypanosomiasis_Homo sapiens_hsa051431.78804825
13Influenza A_Homo sapiens_hsa051641.70501021
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67531293
15Measles_Homo sapiens_hsa051621.58036975
16Tuberculosis_Homo sapiens_hsa051521.55995049
17Caffeine metabolism_Homo sapiens_hsa002321.48518797
18TNF signaling pathway_Homo sapiens_hsa046681.47552245
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45928130
20Legionellosis_Homo sapiens_hsa051341.44650032
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43174204
22Pertussis_Homo sapiens_hsa051331.43143377
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.40785445
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38890866
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33283757
26Antigen processing and presentation_Homo sapiens_hsa046121.32718996
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32255624
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30819459
29B cell receptor signaling pathway_Homo sapiens_hsa046621.27484127
30Toxoplasmosis_Homo sapiens_hsa051451.27367565
31Rheumatoid arthritis_Homo sapiens_hsa053231.26352596
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.23501540
33T cell receptor signaling pathway_Homo sapiens_hsa046601.17367631
34Fatty acid biosynthesis_Homo sapiens_hsa000611.17238578
35Allograft rejection_Homo sapiens_hsa053301.14579118
36Complement and coagulation cascades_Homo sapiens_hsa046101.13886152
37Hepatitis C_Homo sapiens_hsa051601.11678789
38Steroid biosynthesis_Homo sapiens_hsa001001.11493113
39Lysine degradation_Homo sapiens_hsa003101.11194488
40Arginine biosynthesis_Homo sapiens_hsa002201.10936570
41Linoleic acid metabolism_Homo sapiens_hsa005911.08911771
42Inositol phosphate metabolism_Homo sapiens_hsa005621.05230546
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02193825
44Lysosome_Homo sapiens_hsa041420.99399917
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95573059
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.95032710
47Phagosome_Homo sapiens_hsa041450.94386297
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93037855
49Peroxisome_Homo sapiens_hsa041460.92911751
50Chemokine signaling pathway_Homo sapiens_hsa040620.92132398
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92034060
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91990402
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91916034
54Sulfur relay system_Homo sapiens_hsa041220.91776463
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91672742
56ABC transporters_Homo sapiens_hsa020100.90502263
57Apoptosis_Homo sapiens_hsa042100.90117820
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87921294
59Herpes simplex infection_Homo sapiens_hsa051680.87706945
60Graft-versus-host disease_Homo sapiens_hsa053320.85540156
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85378394
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85216567
63Dorso-ventral axis formation_Homo sapiens_hsa043200.84662271
64Vitamin digestion and absorption_Homo sapiens_hsa049770.80705421
65Hepatitis B_Homo sapiens_hsa051610.79533272
66PPAR signaling pathway_Homo sapiens_hsa033200.79532492
67Ether lipid metabolism_Homo sapiens_hsa005650.78352403
68Small cell lung cancer_Homo sapiens_hsa052220.77522371
69Prolactin signaling pathway_Homo sapiens_hsa049170.76739305
70Salmonella infection_Homo sapiens_hsa051320.76736664
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.76479078
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75565252
73Hematopoietic cell lineage_Homo sapiens_hsa046400.71192694
74Regulation of autophagy_Homo sapiens_hsa041400.70790085
75Arachidonic acid metabolism_Homo sapiens_hsa005900.70629550
76Amoebiasis_Homo sapiens_hsa051460.70246641
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.68367291
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67404621
79FoxO signaling pathway_Homo sapiens_hsa040680.67185737
80HIF-1 signaling pathway_Homo sapiens_hsa040660.66657286
81Other glycan degradation_Homo sapiens_hsa005110.66254073
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65419475
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64809827
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64767207
85Viral myocarditis_Homo sapiens_hsa054160.63220602
86Chronic myeloid leukemia_Homo sapiens_hsa052200.60812676
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.59743737
88Fatty acid degradation_Homo sapiens_hsa000710.59256752
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58844780
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58502766
91Type II diabetes mellitus_Homo sapiens_hsa049300.57545153
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.57103221
93Non-small cell lung cancer_Homo sapiens_hsa052230.56609068
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55941159
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55918879
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55044318
97Serotonergic synapse_Homo sapiens_hsa047260.53628885
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51846677
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.51497418
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51171848
101Glycerolipid metabolism_Homo sapiens_hsa005610.51038654
102Proteoglycans in cancer_Homo sapiens_hsa052050.50744584
103Choline metabolism in cancer_Homo sapiens_hsa052310.49988114
104Ovarian steroidogenesis_Homo sapiens_hsa049130.49334083
105Taste transduction_Homo sapiens_hsa047420.48899064
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48404619
107Morphine addiction_Homo sapiens_hsa050320.47700799
108Focal adhesion_Homo sapiens_hsa045100.47268736
109Tryptophan metabolism_Homo sapiens_hsa003800.47193082
110Insulin resistance_Homo sapiens_hsa049310.47104082
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46298549
112Shigellosis_Homo sapiens_hsa051310.45183265
113Notch signaling pathway_Homo sapiens_hsa043300.44163101
114Long-term depression_Homo sapiens_hsa047300.44070981
115Phototransduction_Homo sapiens_hsa047440.44042493
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44029403
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.43739128
118Acute myeloid leukemia_Homo sapiens_hsa052210.43640779
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42243005
120Platelet activation_Homo sapiens_hsa046110.42037558
121Olfactory transduction_Homo sapiens_hsa047400.41973425
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41548376
123GnRH signaling pathway_Homo sapiens_hsa049120.41232586
124MicroRNAs in cancer_Homo sapiens_hsa052060.41162325
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.40881256
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40777234
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40625427
128Glioma_Homo sapiens_hsa052140.40472434
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.40065420
130Salivary secretion_Homo sapiens_hsa049700.39858779
131Asthma_Homo sapiens_hsa053100.39784525
132Cholinergic synapse_Homo sapiens_hsa047250.39657495
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.39076870
134ECM-receptor interaction_Homo sapiens_hsa045120.38763732
135Pancreatic cancer_Homo sapiens_hsa052120.38680912
136Bile secretion_Homo sapiens_hsa049760.37990423
137Prostate cancer_Homo sapiens_hsa052150.37602493
138Starch and sucrose metabolism_Homo sapiens_hsa005000.36631886
139MAPK signaling pathway_Homo sapiens_hsa040100.36574565
140Calcium signaling pathway_Homo sapiens_hsa040200.36007268

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