ALPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.71452933
2cardiac myofibril assembly (GO:0055003)9.46932848
3actin-mediated cell contraction (GO:0070252)9.00384153
4myofibril assembly (GO:0030239)8.70989127
5cardiac muscle contraction (GO:0060048)7.60779637
6cardiac muscle tissue morphogenesis (GO:0055008)7.22308126
7cardiac muscle cell development (GO:0055013)6.97724769
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.86560658
9heart process (GO:0003015)6.72085290
10heart contraction (GO:0060047)6.72085290
11regulation of skeletal muscle contraction (GO:0014819)6.67575602
12actin filament-based movement (GO:0030048)6.66577373
13actomyosin structure organization (GO:0031032)6.61899836
14cardiac cell development (GO:0055006)6.57892755
15muscle tissue morphogenesis (GO:0060415)6.53822587
16striated muscle contraction (GO:0006941)6.50608772
17cardiac muscle hypertrophy (GO:0003300)6.44477802
18ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.33285964
19regulation of relaxation of muscle (GO:1901077)6.21674085
20striated muscle hypertrophy (GO:0014897)6.13955660
21adult heart development (GO:0007512)6.00998553
22negative regulation of potassium ion transmembrane transport (GO:1901380)6.00849841
23negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.71229926
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.64591552
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.63731631
26plasma membrane repair (GO:0001778)5.60273475
27regulation of actin filament-based movement (GO:1903115)5.54516922
28tricarboxylic acid cycle (GO:0006099)5.51198514
29response to muscle activity (GO:0014850)5.49113337
30muscle hypertrophy (GO:0014896)5.45983167
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39969009
32negative regulation of striated muscle cell apoptotic process (GO:0010664)5.30868399
33regulation of sarcomere organization (GO:0060297)5.28302588
34sarcoplasmic reticulum calcium ion transport (GO:0070296)5.20466793
35creatine metabolic process (GO:0006600)5.20012924
36oxidative phosphorylation (GO:0006119)5.17725136
37regulation of the force of heart contraction (GO:0002026)5.01631711
38regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.00222837
39ATP synthesis coupled proton transport (GO:0015986)4.95891731
40energy coupled proton transport, down electrochemical gradient (GO:0015985)4.95891731
41regulation of striated muscle contraction (GO:0006942)4.86409512
42heart trabecula formation (GO:0060347)4.82868350
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.78137925
44regulation of cardioblast differentiation (GO:0051890)4.67821332
45skeletal muscle adaptation (GO:0043501)4.66604141
46ventricular cardiac muscle cell action potential (GO:0086005)4.63083995
47skeletal muscle fiber development (GO:0048741)4.62089764
48regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.54707387
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.53585164
50skeletal muscle contraction (GO:0003009)4.52142276
51bundle of His cell to Purkinje myocyte communication (GO:0086069)4.41624944
52carnitine shuttle (GO:0006853)4.36208805
53negative regulation of protein localization to cell surface (GO:2000009)4.36165705
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.35931855
55myotube cell development (GO:0014904)4.32616204
56cardiac muscle adaptation (GO:0014887)4.32222244
57cardiac muscle hypertrophy in response to stress (GO:0014898)4.32222244
58muscle hypertrophy in response to stress (GO:0003299)4.32222244
59regulation of cell communication by electrical coupling (GO:0010649)4.25283165
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.21525333
61regulation of ATPase activity (GO:0043462)4.21181898
62regulation of ATP catabolic process (GO:1903289)4.21181898
63striated muscle cell development (GO:0055002)4.17907154
64NADH metabolic process (GO:0006734)4.16361377
65response to inactivity (GO:0014854)4.14905852
66regulation of striated muscle cell apoptotic process (GO:0010662)4.13506987
67respiratory electron transport chain (GO:0022904)4.11146162
68muscle contraction (GO:0006936)4.08011787
69regulation of acyl-CoA biosynthetic process (GO:0050812)4.07759258
70electron transport chain (GO:0022900)4.00185689
71skeletal muscle tissue development (GO:0007519)3.93961936
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.93006708
73positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.91023353
74striated muscle atrophy (GO:0014891)3.88971506
75ventricular cardiac muscle cell development (GO:0055015)3.88370473
76glycogen catabolic process (GO:0005980)3.84553204
77muscle cell fate commitment (GO:0042693)3.83295238
78regulation of membrane repolarization (GO:0060306)3.82410827
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.80773420
80regulation of cofactor metabolic process (GO:0051193)3.79888620
81regulation of coenzyme metabolic process (GO:0051196)3.79888620
82muscle system process (GO:0003012)3.76603705
83muscle adaptation (GO:0043500)3.67962579
84muscle cell cellular homeostasis (GO:0046716)3.67808157
85regulation of muscle contraction (GO:0006937)3.65309981
86fatty acid transmembrane transport (GO:1902001)3.62270596
87striated muscle adaptation (GO:0014888)3.61236137
88muscle cell development (GO:0055001)3.59551603
89regulation of cardiac muscle cell apoptotic process (GO:0010665)3.58616489
90glucan catabolic process (GO:0009251)3.57757134
91glycogen biosynthetic process (GO:0005978)3.54545326
92glucan biosynthetic process (GO:0009250)3.54545326
93regulation of heart rate (GO:0002027)3.53036749
94cytidine deamination (GO:0009972)3.50713289
95cytidine metabolic process (GO:0046087)3.50713289
96cytidine catabolic process (GO:0006216)3.50713289
97regulation of calcium ion transmembrane transport (GO:1903169)3.48258846
98regulation of calcium ion transmembrane transporter activity (GO:1901019)3.48258846
99cell communication involved in cardiac conduction (GO:0086065)3.45014614
100cardiac muscle cell action potential involved in contraction (GO:0086002)3.43968623
101muscle fiber development (GO:0048747)3.43702732
102regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43291109
103muscle atrophy (GO:0014889)3.43258141
104cardiac muscle cell action potential (GO:0086001)3.42707726
105muscle organ development (GO:0007517)3.39649959
106muscle structure development (GO:0061061)3.38412209
107pyrimidine ribonucleoside catabolic process (GO:0046133)3.35075187
108cellular polysaccharide catabolic process (GO:0044247)3.34617207
109ATP biosynthetic process (GO:0006754)3.33857360
110regulation of cardiac muscle cell contraction (GO:0086004)3.32959821
111outflow tract septum morphogenesis (GO:0003148)3.31459188
112regulation of muscle system process (GO:0090257)3.31127592
113cardiac chamber formation (GO:0003207)3.31110717
114regulation of heart contraction (GO:0008016)3.31026394
115regulation of cardiac muscle contraction (GO:0055117)3.29944092
116cell communication by electrical coupling (GO:0010644)3.29000677
117negative regulation of skeletal muscle tissue development (GO:0048642)3.27061607
118positive regulation of myotube differentiation (GO:0010831)3.24652919
119relaxation of cardiac muscle (GO:0055119)3.21642183
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18713843
121trabecula formation (GO:0060343)3.18491724
122negative regulation of myotube differentiation (GO:0010832)3.18244963
123regulation of myoblast differentiation (GO:0045661)3.17684145
124skeletal muscle tissue regeneration (GO:0043403)3.14618568
125carnitine transmembrane transport (GO:1902603)3.11350582
126negative regulation of calcium ion transmembrane transport (GO:1903170)3.11028725
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.11028725
128positive regulation of cation channel activity (GO:2001259)3.10787062
129striated muscle tissue development (GO:0014706)3.09616327
1302-oxoglutarate metabolic process (GO:0006103)3.08707404
131negative regulation of potassium ion transport (GO:0043267)3.07706508
132negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05930790
133actin-myosin filament sliding (GO:0033275)10.7349245
134muscle filament sliding (GO:0030049)10.7349245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse6.27235139
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.19231772
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.65582923
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.41293873
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.21760199
6MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.43358826
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.28579911
8TBX20_22328084_ChIP-Seq_HEART_Mouse4.25153864
9TBX20_22080862_ChIP-Seq_HEART_Mouse4.25153864
10ESR1_20079471_ChIP-ChIP_T-47D_Human4.11238400
11EZH2_22144423_ChIP-Seq_EOC_Human3.68430189
12* GATA4_21415370_ChIP-Seq_HL-1_Mouse3.47705940
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.36488381
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.69774255
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.42501026
16* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.42053077
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.29381408
18ZNF263_19887448_ChIP-Seq_K562_Human2.27830892
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23210361
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22333836
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19301452
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16768119
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03897325
24BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.03825234
25* ISL1_27105846_Chip-Seq_CPCs_Mouse1.85249408
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82438769
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80748975
28GATA1_22025678_ChIP-Seq_K562_Human1.77368821
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.74300156
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70812233
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68249491
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.65149826
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.61483878
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49902894
35* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38354202
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.34293635
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34143748
38* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30999537
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27624940
40GBX2_23144817_ChIP-Seq_PC3_Human1.23292965
41DROSHA_22980978_ChIP-Seq_HELA_Human1.21982489
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19902018
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.19613459
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.17808125
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17567384
46SPI1_20517297_ChIP-Seq_HL60_Human1.17559270
47TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17185153
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15495618
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14898654
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11665308
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11224233
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11096285
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10341051
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10341051
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10324298
56SMAD4_21741376_ChIP-Seq_HESCs_Human1.09672572
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09475347
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08956129
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08581837
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.06637467
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05494511
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05089314
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03027762
64* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01990632
65CTCF_27219007_Chip-Seq_Bcells_Human1.01779534
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00124013
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99964605
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99903006
69ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99142542
70THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98716723
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98506878
72RXR_22158963_ChIP-Seq_LIVER_Mouse0.98345861
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98290433
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97544197
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96633695
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.95395135
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95156891
78CLOCK_20551151_ChIP-Seq_293T_Human0.95026890
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94979244
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94575060
81* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94127962
82CBX2_27304074_Chip-Seq_ESCs_Mouse0.92718989
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92561970
84RARB_27405468_Chip-Seq_BRAIN_Mouse0.92272988
85SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91856281
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91720343
87VDR_22108803_ChIP-Seq_LS180_Human0.91484729
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91384850
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91103327
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91026245
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90866473
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.90434496
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89850132
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89397769
95* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89098070
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89061204
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88200534
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88051254
99OCT4_20526341_ChIP-Seq_ESCs_Human0.87288313
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.86759492
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86476852
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86476852
103CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86062309
104RNF2_27304074_Chip-Seq_ESCs_Mouse0.85208006
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84693618
106SMAD4_21799915_ChIP-Seq_A2780_Human0.84486045
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83824190
108GF1_26923725_Chip-Seq_HPCs_Mouse0.83699370
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.83401434
110TP63_22573176_ChIP-Seq_HFKS_Human0.83236167
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82923690
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82474232
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82345368
114MYC_27129775_Chip-Seq_CORNEA_Mouse0.82080841
115JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81850912
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81533166
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81214086
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81179274
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81157024
120YY1_22570637_ChIP-Seq_MALME-3M_Human0.80807411
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80180105
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78298989
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77066337
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76642460
125* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76416355
126TP63_17297297_ChIP-ChIP_HaCaT_Human0.75809989
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.75595410
128* MYC_19829295_ChIP-Seq_ESCs_Human0.75571893
129AR_19668381_ChIP-Seq_PC3_Human0.75433909
130GATA1_19941826_ChIP-Seq_K562_Human0.75213100
131TDRD3_21172665_ChIP-Seq_MCF-7_Human0.74422962
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74156386
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73904202
134ZNF274_21170338_ChIP-Seq_K562_Hela0.73251493
135E2F1_20622854_ChIP-Seq_HELA_Human0.70246461
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.69602939
137BCL6_27268052_Chip-Seq_Bcells_Human0.65941717
138CJUN_26792858_Chip-Seq_BT549_Human0.64750846
139ERA_21632823_ChIP-Seq_H3396_Human0.63780962
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.63012013
141* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62446722
142BCAT_22108803_ChIP-Seq_LS180_Human0.62415781
143YY1_21170310_ChIP-Seq_MESCs_Mouse0.62305983
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.62058122
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.61580200
146RAC3_21632823_ChIP-Seq_H3396_Human0.61362742
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.61221423
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.60750574
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.60508937
150ATF3_27146783_Chip-Seq_COLON_Human0.60463911
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.59238232
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.58868576
153JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.58778342
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.57387407
155CIITA_25753668_ChIP-Seq_RAJI_Human0.57277576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.74393863
2MP0002837_dystrophic_cardiac_calcinosis5.61530624
3MP0000749_muscle_degeneration5.43217166
4MP0003646_muscle_fatigue4.91610766
5MP0000751_myopathy4.78247235
6MP0004036_abnormal_muscle_relaxation4.53124978
7MP0004215_abnormal_myocardial_fiber4.03175947
8MP0005330_cardiomyopathy3.85437685
9MP0004145_abnormal_muscle_electrophysio3.45226246
10MP0004087_abnormal_muscle_fiber3.39007099
11MP0002972_abnormal_cardiac_muscle3.37473588
12MP0005620_abnormal_muscle_contractility2.99600370
13MP0008775_abnormal_heart_ventricle2.94558250
14MP0002106_abnormal_muscle_physiology2.89208042
15MP0010630_abnormal_cardiac_muscle2.78380098
16MP0002269_muscular_atrophy2.68656995
17MP0003137_abnormal_impulse_conducting2.57666774
18MP0001544_abnormal_cardiovascular_syste2.54703315
19MP0005385_cardiovascular_system_phenoty2.54703315
20MP0000750_abnormal_muscle_regeneration2.48738436
21MP0003221_abnormal_cardiomyocyte_apopto2.48328982
22MP0006138_congestive_heart_failure2.47302089
23MP0000747_muscle_weakness2.46752613
24MP0004510_myositis2.43987726
25MP0003828_pulmonary_edema2.34563014
26MP0005369_muscle_phenotype2.31855853
27MP0004484_altered_response_of2.22476370
28MP0000759_abnormal_skeletal_muscle2.21470100
29MP0002127_abnormal_cardiovascular_syste2.07242459
30MP0004085_abnormal_heartbeat2.05804577
31MP0003950_abnormal_plasma_membrane1.99770297
32MP0006036_abnormal_mitochondrial_physio1.88118860
33MP0004130_abnormal_muscle_cell1.84244033
34MP0005451_abnormal_body_composition1.82238179
35MP0004233_abnormal_muscle_weight1.73742473
36MP0003567_abnormal_fetal_cardiomyocyte1.73212826
37MP0000013_abnormal_adipose_tissue1.70041662
38MP0002332_abnormal_exercise_endurance1.55557691
39MP0004270_analgesia1.40851200
40MP0001661_extended_life_span1.29209605
41MP0000266_abnormal_heart_morphology1.25086190
42MP0003122_maternal_imprinting1.20399783
43MP0006035_abnormal_mitochondrial_morpho1.11200838
44MP0003806_abnormal_nucleotide_metabolis1.10856324
45MP0000003_abnormal_adipose_tissue1.00668361
46MP0003279_aneurysm1.00137195
47MP0009780_abnormal_chondrocyte_physiolo0.96483956
48MP0005670_abnormal_white_adipose0.96160108
49MP0000343_altered_response_to0.91501581
50MP0005266_abnormal_metabolism0.90973209
51MP0002234_abnormal_pharynx_morphology0.88517869
52MP0003566_abnormal_cell_adhesion0.86039966
53MP0005666_abnormal_adipose_tissue0.84256641
54MP0002128_abnormal_blood_circulation0.78989135
55MP0003045_fibrosis0.77855911
56MP0002108_abnormal_muscle_morphology0.76959857
57MP0004272_abnormal_basement_membrane0.75268891
58MP0000733_abnormal_muscle_development0.74564118
59MP0002088_abnormal_embryonic_growth/wei0.70626071
60MP0000230_abnormal_systemic_arterial0.70601054
61MP0010368_abnormal_lymphatic_system0.70476524
62MP0003984_embryonic_growth_retardation0.69675107
63MP0003941_abnormal_skin_development0.69179350
64MP0001299_abnormal_eye_distance/0.66880206
65MP0000767_abnormal_smooth_muscle0.65361944
66MP0002925_abnormal_cardiovascular_devel0.63230027
67MP0009384_cardiac_valve_regurgitation0.62732126
68MP0003123_paternal_imprinting0.62600964
69MP0005165_increased_susceptibility_to0.60393002
70MP0003121_genomic_imprinting0.60130561
71MP0003283_abnormal_digestive_organ0.57931331
72MP0002822_catalepsy0.55823556
73MP0005167_abnormal_blood-brain_barrier0.51859917
74MP0001784_abnormal_fluid_regulation0.50960295
75MP0010030_abnormal_orbit_morphology0.49643759
76MP0001879_abnormal_lymphatic_vessel0.49094364
77MP0000762_abnormal_tongue_morphology0.48185505
78MP0003879_abnormal_hair_cell0.47530425
79MP0001672_abnormal_embryogenesis/_devel0.46522363
80MP0005380_embryogenesis_phenotype0.46522363
81MP0005187_abnormal_penis_morphology0.45887756
82MP0005375_adipose_tissue_phenotype0.44865760
83MP0001614_abnormal_blood_vessel0.44747115
84MP0005623_abnormal_meninges_morphology0.43511527
85MP0004185_abnormal_adipocyte_glucose0.41710533
86MP0003705_abnormal_hypodermis_morpholog0.39649625
87MP0003948_abnormal_gas_homeostasis0.38432217
88MP0003385_abnormal_body_wall0.37011611
89MP0002638_abnormal_pupillary_reflex0.36518360
90MP0004134_abnormal_chest_morphology0.35477545
91MP0001730_embryonic_growth_arrest0.32674007
92MP0002896_abnormal_bone_mineralization0.31793797
93MP0004133_heterotaxia0.30871801
94MP0004147_increased_porphyrin_level0.30288564
95MP0009672_abnormal_birth_weight0.29779724
96MP0002254_reproductive_system_inflammat0.29229434
97MP0005595_abnormal_vascular_smooth0.28854557
98MP0002114_abnormal_axial_skeleton0.28755216
99MP0001697_abnormal_embryo_size0.28103002
100MP0000462_abnormal_digestive_system0.27934466
101MP0002971_abnormal_brown_adipose0.27370344
102MP0005319_abnormal_enzyme/_coenzyme0.27014736
103MP0009697_abnormal_copulation0.26787365
104MP0002133_abnormal_respiratory_system0.25861226
105MP0005388_respiratory_system_phenotype0.25861226
106MP0005376_homeostasis/metabolism_phenot0.25787899
107MP0009250_abnormal_appendicular_skeleto0.25568067
108MP0004197_abnormal_fetal_growth/weight/0.25200024
109MP0002086_abnormal_extraembryonic_tissu0.25176907
110MP0006276_abnormal_autonomic_nervous0.25069058
111MP0001175_abnormal_lung_morphology0.24342084
112MP0005535_abnormal_body_temperature0.24248427
113MP0005334_abnormal_fat_pad0.23980905
114MP0002933_joint_inflammation0.23780782
115MP0003959_abnormal_lean_body0.23196196
116MP0005332_abnormal_amino_acid0.22403520
117MP0003115_abnormal_respiratory_system0.22078454
118MP0009703_decreased_birth_body0.22064200
119MP0002168_other_aberrant_phenotype0.21888147
120MP0004043_abnormal_pH_regulation0.20523815
121MP0008569_lethality_at_weaning0.20074434
122MP0002734_abnormal_mechanical_nocicepti0.20003219
123MP0004858_abnormal_nervous_system0.19722570
124MP0002080_prenatal_lethality0.17974989
125MP0002078_abnormal_glucose_homeostasis0.17660854
126MP0001727_abnormal_embryo_implantation0.17008043
127MP0003935_abnormal_craniofacial_develop0.16003666
128MP0008438_abnormal_cutaneous_collagen0.14391639
129MP0005452_abnormal_adipose_tissue0.13601390

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.75263846
2Sudden death (HP:0001699)7.37707346
3Exercise-induced myalgia (HP:0003738)7.17587675
4Calf muscle hypertrophy (HP:0008981)7.02899804
5Muscle hypertrophy of the lower extremities (HP:0008968)6.60545312
6Ventricular tachycardia (HP:0004756)6.08506513
7Subaortic stenosis (HP:0001682)5.55176203
8Abnormality of the left ventricular outflow tract (HP:0011103)5.55176203
9Abnormality of the calf musculature (HP:0001430)5.46317335
10Atrial fibrillation (HP:0005110)5.46111626
11Lipoatrophy (HP:0100578)5.28783635
12Hyporeflexia of lower limbs (HP:0002600)5.27543310
13Muscle fiber splitting (HP:0003555)5.20951046
14Myoglobinuria (HP:0002913)5.19070073
15Primary atrial arrhythmia (HP:0001692)5.07167070
16Supraventricular tachycardia (HP:0004755)4.92031524
17Muscle fiber inclusion bodies (HP:0100299)4.87804954
18Supraventricular arrhythmia (HP:0005115)4.80661321
19EMG: myopathic abnormalities (HP:0003458)4.79270940
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.77273207
21Type 1 muscle fiber predominance (HP:0003803)4.55133829
22Rhabdomyolysis (HP:0003201)4.33980225
23Dilated cardiomyopathy (HP:0001644)4.32760280
24Nemaline bodies (HP:0003798)4.31663838
25Right ventricular cardiomyopathy (HP:0011663)4.09007830
26Syncope (HP:0001279)3.74594296
27Palpitations (HP:0001962)3.73266019
28Prolonged QT interval (HP:0001657)3.72711716
29Asymmetric septal hypertrophy (HP:0001670)3.66197073
30Ventricular arrhythmia (HP:0004308)3.60840535
31Increased connective tissue (HP:0009025)3.57514253
32Neck muscle weakness (HP:0000467)3.35152067
33Calcaneovalgus deformity (HP:0001848)3.33970989
34Bundle branch block (HP:0011710)3.33970559
35Centrally nucleated skeletal muscle fibers (HP:0003687)3.24274048
36Myotonia (HP:0002486)3.21588300
37Difficulty running (HP:0009046)3.21038012
38Distal lower limb muscle weakness (HP:0009053)3.19746455
39Malignant hyperthermia (HP:0002047)3.08548635
40Absent phalangeal crease (HP:0006109)3.05162372
41Frequent falls (HP:0002359)3.03257964
42Rimmed vacuoles (HP:0003805)3.00221125
43Acute necrotizing encephalopathy (HP:0006965)2.96690859
44Heart block (HP:0012722)2.96103250
45Muscle stiffness (HP:0003552)2.93163511
46Deformed tarsal bones (HP:0008119)2.91473806
47Areflexia of lower limbs (HP:0002522)2.91380956
48Abnormal mitochondria in muscle tissue (HP:0008316)2.89189527
49Congenital malformation of the right heart (HP:0011723)2.87692258
50Double outlet right ventricle (HP:0001719)2.87692258
51Left ventricular hypertrophy (HP:0001712)2.83907569
52Distal lower limb amyotrophy (HP:0008944)2.82605724
53Ragged-red muscle fibers (HP:0003200)2.80353339
54Abnormal atrioventricular conduction (HP:0005150)2.76405558
55Abnormal EKG (HP:0003115)2.74307310
56Exercise intolerance (HP:0003546)2.73419469
57Atrioventricular block (HP:0001678)2.71239198
58Hepatic necrosis (HP:0002605)2.71005707
59Fetal akinesia sequence (HP:0001989)2.68576184
60Ventricular fibrillation (HP:0001663)2.63468498
61Bulbar palsy (HP:0001283)2.60530176
62Palmoplantar keratoderma (HP:0000982)2.60255187
63Generalized muscle weakness (HP:0003324)2.60188737
64Distal arthrogryposis (HP:0005684)2.58655453
65EMG: neuropathic changes (HP:0003445)2.49757171
66Mitochondrial inheritance (HP:0001427)2.48942371
67Abnormal finger flexion creases (HP:0006143)2.48828257
68Difficulty climbing stairs (HP:0003551)2.44949262
69Hepatocellular necrosis (HP:0001404)2.41565606
70Fatigable weakness (HP:0003473)2.41166499
71Abnormality of the neuromuscular junction (HP:0003398)2.41166499
72Acute encephalopathy (HP:0006846)2.40435740
73Increased CSF lactate (HP:0002490)2.39474150
74Popliteal pterygium (HP:0009756)2.38158038
75Progressive macrocephaly (HP:0004481)2.37721739
76Abnormality of skeletal muscle fiber size (HP:0012084)2.37059994
77Mildly elevated creatine phosphokinase (HP:0008180)2.34010869
78Increased serum pyruvate (HP:0003542)2.31344958
79Abnormality of glycolysis (HP:0004366)2.31344958
80Abnormality of the foot musculature (HP:0001436)2.31310989
81Conjunctival hamartoma (HP:0100780)2.28589407
82Myopathic facies (HP:0002058)2.27172723
83Round ear (HP:0100830)2.24094291
84Increased variability in muscle fiber diameter (HP:0003557)2.21957255
85Lower limb amyotrophy (HP:0007210)2.18589397
86Hyperkalemia (HP:0002153)2.12061208
87Spinal rigidity (HP:0003306)2.10066070
88Hypoplastic left heart (HP:0004383)2.09856322
89Pheochromocytoma (HP:0002666)2.07115882
90Neoplasm of the adrenal gland (HP:0100631)2.06633558
91Foot dorsiflexor weakness (HP:0009027)2.05351330
92Cerebral edema (HP:0002181)2.01934572
93Muscular dystrophy (HP:0003560)2.01893813
94Diaphragmatic weakness (HP:0009113)2.01427960
95Increased muscle lipid content (HP:0009058)1.99184754
96Waddling gait (HP:0002515)1.98846283
97Proximal amyotrophy (HP:0007126)1.98491868
98Slender build (HP:0001533)1.96751055
99Abnormality of the calcaneus (HP:0008364)1.96183446
100Abnormality of the shoulder girdle musculature (HP:0001435)1.94381590
101Increased intramyocellular lipid droplets (HP:0012240)1.91620340
102Hypoglycemic coma (HP:0001325)1.89745645
103Neuroendocrine neoplasm (HP:0100634)1.89436073
104Lactic acidosis (HP:0003128)1.88189511
105Hypoplastic heart (HP:0001961)1.86705907
106Respiratory insufficiency due to muscle weakness (HP:0002747)1.85902812
107Limb-girdle muscle atrophy (HP:0003797)1.85458100
108Gowers sign (HP:0003391)1.85315653
109Patent foramen ovale (HP:0001655)1.85069311
110Ulnar deviation of the wrist (HP:0003049)1.84627978
111Steppage gait (HP:0003376)1.83973254
112Respiratory failure (HP:0002878)1.82771989
113Congestive heart failure (HP:0001635)1.81867498
114Ketoacidosis (HP:0001993)1.81520869
115Limited hip movement (HP:0008800)1.80962560
116Scapular winging (HP:0003691)1.80074096
117Progressive muscle weakness (HP:0003323)1.77091882
118Type 2 muscle fiber atrophy (HP:0003554)1.73412156
119Lipid accumulation in hepatocytes (HP:0006561)1.72916442
120Weak cry (HP:0001612)1.71928488
121Hip contracture (HP:0003273)1.69577409
122Tinnitus (HP:0000360)1.69120689
123Dicarboxylic aciduria (HP:0003215)1.68467942
124Nonprogressive disorder (HP:0003680)1.63862222
125Limb-girdle muscle weakness (HP:0003325)1.60299418
126Facial diplegia (HP:0001349)1.57978903
127Metatarsus adductus (HP:0001840)1.56517561
128Muscle fiber atrophy (HP:0100295)1.54223457
129Aplasia of the musculature (HP:0100854)1.47994854
130Abnormality of the hip-girdle musculature (HP:0001445)1.46427488
131Abnormality of the musculature of the pelvis (HP:0001469)1.46427488
132Long clavicles (HP:0000890)1.46305323
133Easy fatigability (HP:0003388)1.43212583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.51322494
2MYLK4.74401714
3TTN4.31019739
4ZAK3.13615598
5PHKG13.13395021
6PHKG23.13395021
7STK243.02726670
8PKN22.77956997
9PIK3CA2.75203435
10MUSK2.65921520
11DMPK2.57156652
12PDK32.00445942
13PDK42.00445942
14NEK11.95145495
15BCKDK1.89955649
16LMTK21.88855278
17STK38L1.82814608
18ILK1.43792865
19CDC42BPA1.43693199
20TIE11.43466952
21TRPM71.38708518
22PINK11.34946235
23MAP2K31.34006543
24FLT31.32728593
25EEF2K1.22017487
26TRIB31.17734516
27PIK3CG1.10003294
28PDK21.09575910
29STK41.03346263
30LIMK11.01768287
31ROCK10.96214775
32DAPK30.91456527
33MARK10.90989605
34NME10.90590175
35MAPK120.90572602
36MOS0.88161267
37MAP3K70.86032024
38MAP3K30.85100324
39CAMK2D0.84708616
40PAK30.80921824
41PRKD10.77579369
42PRKAA20.72758782
43PKN10.67522757
44PRKAA10.67429863
45MAP3K50.63784665
46BRSK20.62933060
47GRK70.58385597
48MAP2K10.55911659
49MAPKAPK30.55220355
50MARK30.55158297
51CAMK10.54405186
52SIK10.54011236
53MAP3K130.53314812
54INSRR0.51454704
55AKT20.50222496
56MAPK40.47117222
57PTK2B0.46092497
58TESK10.45258951
59PRKACB0.44941288
60ERBB30.44775032
61DYRK1B0.44068271
62RPS6KC10.43445045
63RPS6KL10.43445045
64CAMK2B0.43318621
65ROCK20.42817747
66MARK20.41964982
67WNK40.40782094
68PRKD30.39054820
69NEK90.38429949
70MET0.38414077
71CCNB10.36945521
72MTOR0.36767501
73RIPK10.36700034
74CAMK2A0.36628426
75RPS6KA60.35026498
76PAK20.34897054
77STK30.33692252
78PRKG10.33363027
79KDR0.33298714
80PRKACA0.33208276
81NLK0.32831276
82MAP3K100.31841251
83CAMK2G0.31793005
84AKT30.31618260
85CAMK40.31401975
86FGFR40.31283416
87EPHB10.30968777
88PTK20.29363912
89MAP2K60.29278836
90RPS6KB20.28373147
91FER0.27802586
92KSR20.27264005
93NUAK10.25519481
94DAPK20.25403319
95STK110.25118171
96EPHA30.24864531
97STK380.24495074
98MAP3K10.24413272
99MAPK100.23790265
100MAP3K90.23508883
101PLK40.23082111
102PRKG20.22966307
103FGFR30.22780888
104PDPK10.22625940
105SGK4940.22456303
106SGK2230.22456303
107FGFR10.22356510
108MAP3K60.22168331
109BRSK10.21777367
110PDGFRA0.20870088
111WNK10.20432573
112TGFBR20.16526841
113PRKACG0.16265280
114LATS20.15726941
115PRKCE0.14957480
116MAP2K40.14693282
117MAPKAPK20.12750312
118MAPK110.12428051
119EPHB20.12417637
120SGK20.12383209
121SGK30.12092538
122AURKB0.11181273
123RPS6KA10.10964973
124CDK40.09895552
125NME20.08561387
126PRKCH0.08133751
127SGK10.07143811
128RPS6KA30.07052125
129PRKCQ0.05630720
130LATS10.05238049
131MAPK70.05094934
132ICK0.04914496

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042605.59536170
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.54513344
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.37814865
4Dilated cardiomyopathy_Homo sapiens_hsa054144.15039087
5Parkinsons disease_Homo sapiens_hsa050123.88772109
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.67000448
7Oxidative phosphorylation_Homo sapiens_hsa001903.66059989
8Alzheimers disease_Homo sapiens_hsa050102.71712712
9Carbon metabolism_Homo sapiens_hsa012002.63450392
10Huntingtons disease_Homo sapiens_hsa050162.60044393
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.57224620
12Propanoate metabolism_Homo sapiens_hsa006402.49933738
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36651697
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.09281949
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01864257
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98226164
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96160252
18Fatty acid degradation_Homo sapiens_hsa000711.81398100
19Biosynthesis of amino acids_Homo sapiens_hsa012301.68524406
20Pyruvate metabolism_Homo sapiens_hsa006201.60640776
21Viral myocarditis_Homo sapiens_hsa054161.45773441
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40451715
23Fatty acid metabolism_Homo sapiens_hsa012121.36876505
24Galactose metabolism_Homo sapiens_hsa000521.35475085
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31056688
26Starch and sucrose metabolism_Homo sapiens_hsa005001.28073803
27Glucagon signaling pathway_Homo sapiens_hsa049221.18687611
28Fructose and mannose metabolism_Homo sapiens_hsa000511.17630674
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13713895
30Tight junction_Homo sapiens_hsa045301.10703614
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09007450
32HIF-1 signaling pathway_Homo sapiens_hsa040661.03935491
33Central carbon metabolism in cancer_Homo sapiens_hsa052300.97179552
34Insulin resistance_Homo sapiens_hsa049310.87770738
35Insulin signaling pathway_Homo sapiens_hsa049100.83076623
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81992386
37Fatty acid elongation_Homo sapiens_hsa000620.81684873
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80457390
39Focal adhesion_Homo sapiens_hsa045100.79953859
40GnRH signaling pathway_Homo sapiens_hsa049120.74308563
41Ovarian steroidogenesis_Homo sapiens_hsa049130.72288868
42Pancreatic secretion_Homo sapiens_hsa049720.71000110
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.70981839
44Calcium signaling pathway_Homo sapiens_hsa040200.70793842
45Oxytocin signaling pathway_Homo sapiens_hsa049210.70240151
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68164939
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.60490282
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57264080
49Long-term potentiation_Homo sapiens_hsa047200.55725391
50Phenylalanine metabolism_Homo sapiens_hsa003600.53808410
51Proteasome_Homo sapiens_hsa030500.53768912
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51608630
53Protein digestion and absorption_Homo sapiens_hsa049740.50456402
54Butanoate metabolism_Homo sapiens_hsa006500.50092052
55PPAR signaling pathway_Homo sapiens_hsa033200.50058578
56Adherens junction_Homo sapiens_hsa045200.49893634
57AMPK signaling pathway_Homo sapiens_hsa041520.48712528
58Bile secretion_Homo sapiens_hsa049760.48399550
59Salivary secretion_Homo sapiens_hsa049700.46175991
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.45769631
61Pentose phosphate pathway_Homo sapiens_hsa000300.44128566
62Lysine degradation_Homo sapiens_hsa003100.41320657
63Arginine and proline metabolism_Homo sapiens_hsa003300.40648144
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.40493402
65Metabolic pathways_Homo sapiens_hsa011000.39758876
66Cholinergic synapse_Homo sapiens_hsa047250.36355735
67RNA degradation_Homo sapiens_hsa030180.35950015
68Tyrosine metabolism_Homo sapiens_hsa003500.35723227
69mTOR signaling pathway_Homo sapiens_hsa041500.33561247
70MAPK signaling pathway_Homo sapiens_hsa040100.32868661
71Amphetamine addiction_Homo sapiens_hsa050310.32612689
72Nitrogen metabolism_Homo sapiens_hsa009100.31827414
73Circadian rhythm_Homo sapiens_hsa047100.29944754
74ABC transporters_Homo sapiens_hsa020100.29124393
75Type II diabetes mellitus_Homo sapiens_hsa049300.28977961
76Long-term depression_Homo sapiens_hsa047300.28899814
77Purine metabolism_Homo sapiens_hsa002300.28834767
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28479996
79Basal cell carcinoma_Homo sapiens_hsa052170.28164575
80ECM-receptor interaction_Homo sapiens_hsa045120.27151399
81Peroxisome_Homo sapiens_hsa041460.27052184
82Gap junction_Homo sapiens_hsa045400.26878096
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.26293414
84Histidine metabolism_Homo sapiens_hsa003400.26138866
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26130465
86beta-Alanine metabolism_Homo sapiens_hsa004100.25925455
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25728634
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25410557
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25318998
90Regulation of autophagy_Homo sapiens_hsa041400.25086786
91Tryptophan metabolism_Homo sapiens_hsa003800.24520075
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23939235
93Proteoglycans in cancer_Homo sapiens_hsa052050.23539743
94Thyroid hormone synthesis_Homo sapiens_hsa049180.21771117
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20782321
96VEGF signaling pathway_Homo sapiens_hsa043700.20167578
97RNA polymerase_Homo sapiens_hsa030200.18978363
98Hippo signaling pathway_Homo sapiens_hsa043900.18715932
99Mismatch repair_Homo sapiens_hsa034300.17898530
100Fatty acid biosynthesis_Homo sapiens_hsa000610.17855961
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17472302
102cAMP signaling pathway_Homo sapiens_hsa040240.14429233
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14109915
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13692727
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10525416
106Amoebiasis_Homo sapiens_hsa051460.08622968
107FoxO signaling pathway_Homo sapiens_hsa040680.08197632
108Arachidonic acid metabolism_Homo sapiens_hsa005900.07172913
109Renin secretion_Homo sapiens_hsa049240.06474840
110Insulin secretion_Homo sapiens_hsa049110.06383940
111Arginine biosynthesis_Homo sapiens_hsa002200.06299720
112TGF-beta signaling pathway_Homo sapiens_hsa043500.05769084
113Circadian entrainment_Homo sapiens_hsa047130.05312032
114Melanogenesis_Homo sapiens_hsa049160.04076513
115Platelet activation_Homo sapiens_hsa046110.02692632
116HTLV-I infection_Homo sapiens_hsa051660.02108355
117Hedgehog signaling pathway_Homo sapiens_hsa043400.01845913
118Oocyte meiosis_Homo sapiens_hsa041140.00749889
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.00630814
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00340834
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0357279
122PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0335585
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0293041
124Ribosome_Homo sapiens_hsa03010-0.0219776
125Gastric acid secretion_Homo sapiens_hsa04971-0.0207609
126Ubiquitin mediated proteolysis_Homo sapiens_hsa04120-0.0160955

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