ALPPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)8.46146614
2purine nucleobase biosynthetic process (GO:0009113)8.20626497
3apoptotic process involved in morphogenesis (GO:0060561)8.06713498
4mesenchymal cell proliferation (GO:0010463)7.25004844
5nucleobase biosynthetic process (GO:0046112)7.05362430
6craniofacial suture morphogenesis (GO:0097094)7.01867505
7pantothenate metabolic process (GO:0015939)6.51754590
8ribosome assembly (GO:0042255)6.42345804
9GMP metabolic process (GO:0046037)6.01980259
10apoptotic process involved in development (GO:1902742)5.94289614
11ribosomal small subunit assembly (GO:0000028)5.89289714
12nodal signaling pathway (GO:0038092)5.70873362
13folic acid transport (GO:0015884)5.67938725
14folic acid metabolic process (GO:0046655)5.64422300
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.42507331
16regulation of spindle organization (GO:0090224)5.39251361
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.33643094
18mitotic metaphase plate congression (GO:0007080)5.31545800
19histone arginine methylation (GO:0034969)5.31518999
20positive regulation of SMAD protein import into nucleus (GO:0060391)5.31019035
21lung-associated mesenchyme development (GO:0060484)5.01739653
22ribosome biogenesis (GO:0042254)5.00289727
23negative regulation of androgen receptor signaling pathway (GO:0060766)4.96519969
24CDP-diacylglycerol metabolic process (GO:0046341)4.79176541
25negative regulation of microtubule polymerization (GO:0031115)4.71813883
26ncRNA 3-end processing (GO:0043628)4.71087431
27developmental programmed cell death (GO:0010623)4.65394667
28biotin metabolic process (GO:0006768)4.57495032
29proteasome assembly (GO:0043248)4.56121625
30pentose metabolic process (GO:0019321)4.55112305
31NADH metabolic process (GO:0006734)4.42978892
32modified amino acid transport (GO:0072337)4.42681283
33rRNA modification (GO:0000154)4.40276427
34S-adenosylmethionine metabolic process (GO:0046500)4.38413983
35blastocyst development (GO:0001824)4.35223254
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.33652674
37regulation of gene expression by genetic imprinting (GO:0006349)4.31930674
38termination of RNA polymerase III transcription (GO:0006386)4.30333544
39transcription elongation from RNA polymerase III promoter (GO:0006385)4.30333544
40autophagic vacuole assembly (GO:0000045)4.26565125
41DNA replication checkpoint (GO:0000076)4.26012489
42amino acid salvage (GO:0043102)4.23951487
43L-methionine salvage (GO:0071267)4.23951487
44L-methionine biosynthetic process (GO:0071265)4.23951487
45regulation of mitotic spindle organization (GO:0060236)4.20581992
46cartilage condensation (GO:0001502)4.19444088
47cell aggregation (GO:0098743)4.19444088
48positive regulation of chromosome segregation (GO:0051984)4.19224142
49activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.16408914
50transcription elongation from RNA polymerase I promoter (GO:0006362)4.09394505
51intestinal epithelial cell development (GO:0060576)4.09182909
52protein complex localization (GO:0031503)4.06172056
53regulation of DNA methylation (GO:0044030)4.06016727
54cofactor transport (GO:0051181)4.05012332
55regulation of SMAD protein import into nucleus (GO:0060390)4.03213712
56termination of RNA polymerase I transcription (GO:0006363)4.01980614
57embryonic process involved in female pregnancy (GO:0060136)4.00947633
58primitive streak formation (GO:0090009)4.00131398
59histone-serine phosphorylation (GO:0035404)3.98964350
60regulation of gene silencing by RNA (GO:0060966)3.98831980
61regulation of posttranscriptional gene silencing (GO:0060147)3.98831980
62regulation of gene silencing by miRNA (GO:0060964)3.98831980
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95683417
64metaphase plate congression (GO:0051310)3.92904800
65guanosine-containing compound biosynthetic process (GO:1901070)3.91058052
66vitamin transport (GO:0051180)3.88814362
67regulation of translation in response to stress (GO:0043555)3.87972704
68morphogenesis of an epithelial fold (GO:0060571)3.87542359
69transcription from RNA polymerase I promoter (GO:0006360)3.87361089
70glycine metabolic process (GO:0006544)3.86899453
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.78890318
727-methylguanosine mRNA capping (GO:0006370)3.77701397
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76693040
74myeloid cell homeostasis (GO:0002262)3.75807931
75regulation of G0 to G1 transition (GO:0070316)3.74411972
76maturation of SSU-rRNA (GO:0030490)3.69538258
77positive regulation of protein homooligomerization (GO:0032464)3.68771271
78mitochondrial RNA metabolic process (GO:0000959)3.67832362
79spindle checkpoint (GO:0031577)3.67064747
80mitotic spindle checkpoint (GO:0071174)3.64341837
81CDP-diacylglycerol biosynthetic process (GO:0016024)3.64330189
82mitochondrial fusion (GO:0008053)3.63910186
83cellular response to zinc ion (GO:0071294)3.63887392
84cellular response to cadmium ion (GO:0071276)3.63874574
85negative regulation of epidermal cell differentiation (GO:0045605)3.63336059
86negative regulation of gene silencing (GO:0060969)3.63262822
877-methylguanosine RNA capping (GO:0009452)3.63236912
88RNA capping (GO:0036260)3.63236912
89methionine biosynthetic process (GO:0009086)3.62440724
90transcription initiation from RNA polymerase I promoter (GO:0006361)3.60008824
91serine family amino acid biosynthetic process (GO:0009070)3.58191788
92ribonucleoprotein complex biogenesis (GO:0022613)3.57350174
93regulation of activin receptor signaling pathway (GO:0032925)3.53054737
94transcription from mitochondrial promoter (GO:0006390)3.51053162
95rRNA processing (GO:0006364)3.50190883
96maturation of 5.8S rRNA (GO:0000460)3.47959201
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47648938
98regulation of chromosome segregation (GO:0051983)3.46885423
99DNA deamination (GO:0045006)3.42099541
100methionine metabolic process (GO:0006555)3.42077894
101positive regulation of interleukin-1 beta secretion (GO:0050718)3.41105898
102negative regulation of chromosome segregation (GO:0051985)3.40429021
103embryonic hindlimb morphogenesis (GO:0035116)3.40300507
104notochord development (GO:0030903)3.40253709
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39654047
106rRNA metabolic process (GO:0016072)3.39514859
107formation of translation preinitiation complex (GO:0001731)3.39092678
108mitotic spindle assembly checkpoint (GO:0007094)3.38574909
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34349975
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34349975
111negative regulation of sister chromatid segregation (GO:0033046)3.34349975
112negative regulation of mitotic sister chromatid separation (GO:2000816)3.34349975
113spliceosomal snRNP assembly (GO:0000387)3.33631613
114mitotic sister chromatid segregation (GO:0000070)3.32790127
115serine family amino acid catabolic process (GO:0009071)3.32704569
116negative regulation of epidermis development (GO:0045683)3.30908407
117viral transcription (GO:0019083)3.30507510
118collecting duct development (GO:0072044)3.29810113
119rRNA methylation (GO:0031167)3.29334632
120genetic imprinting (GO:0071514)3.28433504
121spindle assembly checkpoint (GO:0071173)3.28318280
122maternal placenta development (GO:0001893)3.26111253
123peptidyl-threonine dephosphorylation (GO:0035970)3.25810258
124spindle assembly involved in mitosis (GO:0090307)3.24985361
125pyrimidine nucleoside salvage (GO:0043097)3.24556663
126pyrimidine-containing compound salvage (GO:0008655)3.24556663
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24008153
128protein localization to kinetochore (GO:0034501)3.22591316
129cell fate commitment involved in formation of primary germ layer (GO:0060795)3.20911608
130determination of adult lifespan (GO:0008340)3.19963905
131negative regulation of activin receptor signaling pathway (GO:0032926)3.18955790
132positive regulation of interleukin-1 secretion (GO:0050716)3.18521710
133trophoblast giant cell differentiation (GO:0060707)3.18280716
134mitotic nuclear envelope disassembly (GO:0007077)3.18205915
1354-hydroxyproline metabolic process (GO:0019471)3.17768622
136ribosomal small subunit biogenesis (GO:0042274)3.16742498
137positive regulation of ligase activity (GO:0051351)3.16609452
138meiosis I (GO:0007127)3.15313508
139regulation of mitochondrial translation (GO:0070129)3.14940732
140regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14932174
141protein localization to chromosome, centromeric region (GO:0071459)3.13586706
142DNA-templated transcription, elongation (GO:0006354)3.12789914
143regulation of protein heterodimerization activity (GO:0043497)3.11639037
144cell migration involved in gastrulation (GO:0042074)3.11079792
145regulation of exit from mitosis (GO:0007096)3.09691031
146regulation of centrosome cycle (GO:0046605)3.09149120
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08975057
148negative regulation of ligase activity (GO:0051352)3.08975057
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07382080
150translational termination (GO:0006415)3.06896774
151sulfur amino acid biosynthetic process (GO:0000097)3.05929769
152L-serine metabolic process (GO:0006563)3.05661173
153regulation of cellular respiration (GO:0043457)3.05430536
154transcription elongation from RNA polymerase II promoter (GO:0006368)3.05067003
155nuclear envelope organization (GO:0006998)3.01729423
156vagina development (GO:0060068)3.01704033
157negative regulation of macroautophagy (GO:0016242)3.01469407
158neurotransmitter catabolic process (GO:0042135)2.99820832
159regulation of ubiquitin-protein transferase activity (GO:0051438)2.97491157
160membrane disassembly (GO:0030397)2.97283116
161nuclear envelope disassembly (GO:0051081)2.97283116
162regulation of interleukin-1 beta secretion (GO:0050706)2.96545254
163regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.93433789
164male meiosis I (GO:0007141)2.93364161
165placenta development (GO:0001890)2.91604558
166cell migration in hindbrain (GO:0021535)2.91212290
167histone H4-K8 acetylation (GO:0043982)2.91037430
168histone H4-K5 acetylation (GO:0043981)2.91037430
169glycosphingolipid biosynthetic process (GO:0006688)2.90955960
170proline metabolic process (GO:0006560)2.88519501
171pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.88239566
172UMP metabolic process (GO:0046049)2.88239566
173pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.88239566
174UMP biosynthetic process (GO:0006222)2.88239566
175translational elongation (GO:0006414)2.87486083
176morphogenesis of embryonic epithelium (GO:0016331)2.85811230
177nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83880752
178regulation of oxidative phosphorylation (GO:0002082)2.81355708
179chaperone-mediated protein transport (GO:0072321)2.79453542
180response to dietary excess (GO:0002021)2.78748715
181post-embryonic morphogenesis (GO:0009886)2.78456839
182mitochondrial DNA metabolic process (GO:0032042)2.77882813
183GDP-mannose metabolic process (GO:0019673)2.74888610
184regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74800327
185pseudouridine synthesis (GO:0001522)2.74745140
186chaperone-mediated protein complex assembly (GO:0051131)2.74130817
187intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.73314266
188cellular protein complex localization (GO:0034629)2.72187699
189peptidyl-arginine omega-N-methylation (GO:0035247)2.69790750
190DNA replication initiation (GO:0006270)2.69443516
191negative regulation of retinoic acid receptor signaling pathway (GO:0048387)12.5715057
192cranial suture morphogenesis (GO:0060363)10.6925864
193regulation of retinoic acid receptor signaling pathway (GO:0048385)10.4318194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08176562
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.92533930
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.02372615
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82469734
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.76265261
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71582526
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.68971346
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.64426859
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.56346331
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17696125
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.05834344
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.04260657
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01020905
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90330614
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88364292
16AR_21909140_ChIP-Seq_LNCAP_Human2.69276363
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66101739
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59356327
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.45014994
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39461755
21VDR_23849224_ChIP-Seq_CD4+_Human2.37885890
22ZNF263_19887448_ChIP-Seq_K562_Human2.27585931
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25343293
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24644389
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20785136
26GABP_19822575_ChIP-Seq_HepG2_Human2.09777578
27XRN2_22483619_ChIP-Seq_HELA_Human2.07420453
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05321399
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04143263
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94320543
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89522617
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.83204729
33FOXP3_21729870_ChIP-Seq_TREG_Human1.81109787
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80338762
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79877601
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69821206
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69515327
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69187717
39DCP1A_22483619_ChIP-Seq_HELA_Human1.68218100
40KDM5A_27292631_Chip-Seq_BREAST_Human1.66017482
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65159673
42LXR_22292898_ChIP-Seq_THP-1_Human1.61608517
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.55401757
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54167995
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52501025
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52093105
47TTF2_22483619_ChIP-Seq_HELA_Human1.51591587
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.51267831
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51060130
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51060130
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51060130
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46072315
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45525420
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43415746
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.43103183
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41147460
57CTCF_20526341_ChIP-Seq_ESCs_Human1.40726298
58P68_20966046_ChIP-Seq_HELA_Human1.40234733
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39445689
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37593559
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35543854
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34036769
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.33072928
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.32657382
65SMC4_20622854_ChIP-Seq_HELA_Human1.31655770
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31652873
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31537511
68* BCOR_27268052_Chip-Seq_Bcells_Human1.31222555
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.31209465
70CIITA_25753668_ChIP-Seq_RAJI_Human1.30752651
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30279665
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29856402
73MYC_22102868_ChIP-Seq_BL_Human1.29501398
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27581897
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27349876
76RACK7_27058665_Chip-Seq_MCF-7_Human1.26338564
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25972128
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24180213
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23905325
80SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23602163
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23410748
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21753806
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.21454797
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19989426
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18713356
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17189073
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16625260
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15873065
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11931590
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.11758487
91KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11452880
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11439480
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11025747
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10514081
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09691852
96TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.09309025
97CTCF_27219007_Chip-Seq_Bcells_Human1.08974351
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08715247
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08559242
100* PHF8_20622854_ChIP-Seq_HELA_Human1.07707791
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06698070
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06582447
103CTCF_26484167_Chip-Seq_Bcells_Mouse1.06324611
104CREB1_26743006_Chip-Seq_LNCaP_Human1.05918049
105SA1_27219007_Chip-Seq_Bcells_Human1.04454242
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02981374
107VDR_21846776_ChIP-Seq_THP-1_Human1.02963122
108NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01800360
109STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01741384
110CTCF_21964334_Chip-Seq_Bcells_Human1.00850280
111ELK1_19687146_ChIP-ChIP_HELA_Human1.00820549
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00666637
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99830951
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99737635
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.99569947
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99326591
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98912172
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97354660
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97128211
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95287504
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.94434149
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93039511
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93011393
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91177350
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91098167
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91085193
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90320318
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89984884
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89545479
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87885768
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.87406610
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87288060
133* KAP1_27257070_Chip-Seq_ESCs_Mouse0.86834368
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84856022
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84219401
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82751014
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.81653788
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81118615
139NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79658078
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77730319
141GATA1_22025678_ChIP-Seq_K562_Human0.75957546
142ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75736455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.49098127
2MP0003718_maternal_effect5.10491232
3MP0003111_abnormal_nucleus_morphology5.00328006
4MP0009840_abnormal_foam_cell4.65202793
5MP0008260_abnormal_autophagy4.60831047
6MP0005377_hearing/vestibular/ear_phenot3.85221772
7MP0003878_abnormal_ear_physiology3.85221772
8MP0004233_abnormal_muscle_weight3.75870661
9MP0004957_abnormal_blastocyst_morpholog3.64272256
10MP0010094_abnormal_chromosome_stability3.43757646
11MP0005257_abnormal_intraocular_pressure3.36455480
12MP0000537_abnormal_urethra_morphology3.33977183
13MP0003077_abnormal_cell_cycle3.22466003
14MP0003806_abnormal_nucleotide_metabolis3.10753104
15MP0002254_reproductive_system_inflammat2.86371051
16MP0003786_premature_aging2.80360896
17MP0004133_heterotaxia2.71190299
18MP0001661_extended_life_span2.47611207
19MP0000566_synostosis2.47398829
20MP0003890_abnormal_embryonic-extraembry2.47110014
21MP0005451_abnormal_body_composition2.46321037
22MP0003123_paternal_imprinting2.45705643
23MP0001542_abnormal_bone_strength2.30888032
24MP0008058_abnormal_DNA_repair2.28279554
25MP0001730_embryonic_growth_arrest2.16806788
26MP0008932_abnormal_embryonic_tissue2.14990175
27MP0002822_catalepsy2.11245940
28MP0009780_abnormal_chondrocyte_physiolo2.03261894
29MP0000462_abnormal_digestive_system2.02837095
30MP0002796_impaired_skin_barrier1.93689193
31MP0008057_abnormal_DNA_replication1.92907586
32MP0005395_other_phenotype1.91565448
33MP0010030_abnormal_orbit_morphology1.88703996
34MP0002089_abnormal_postnatal_growth/wei1.78598564
35MP0001346_abnormal_lacrimal_gland1.70663128
36MP0004885_abnormal_endolymph1.69150693
37MP0004264_abnormal_extraembryonic_tissu1.69144309
38MP0005058_abnormal_lysosome_morphology1.67607122
39MP0000350_abnormal_cell_proliferation1.67369056
40MP0003186_abnormal_redox_activity1.65086668
41MP0009333_abnormal_splenocyte_physiolog1.64958257
42MP0009379_abnormal_foot_pigmentation1.64009908
43MP0010307_abnormal_tumor_latency1.63322417
44* MP0005380_embryogenesis_phenotype1.62496038
45* MP0001672_abnormal_embryogenesis/_devel1.62496038
46MP0008007_abnormal_cellular_replicative1.59734030
47MP0004858_abnormal_nervous_system1.58885876
48MP0003221_abnormal_cardiomyocyte_apopto1.57045146
49MP0008877_abnormal_DNA_methylation1.53931824
50MP0004019_abnormal_vitamin_homeostasis1.52116132
51MP0001756_abnormal_urination1.52111657
52MP0003938_abnormal_ear_development1.51926268
53MP0003567_abnormal_fetal_cardiomyocyte1.51446883
54MP0000470_abnormal_stomach_morphology1.49635899
55MP0005076_abnormal_cell_differentiation1.49339892
56MP0003315_abnormal_perineum_morphology1.45212775
57MP0003183_abnormal_peptide_metabolism1.45143600
58MP0000750_abnormal_muscle_regeneration1.41154876
59* MP0002080_prenatal_lethality1.39517513
60MP0001697_abnormal_embryo_size1.34527446
61* MP0003984_embryonic_growth_retardation1.33365340
62MP0001986_abnormal_taste_sensitivity1.32568742
63MP0003453_abnormal_keratinocyte_physiol1.32244182
64* MP0002088_abnormal_embryonic_growth/wei1.30254044
65MP0000747_muscle_weakness1.29297538
66MP0005501_abnormal_skin_physiology1.22808166
67MP0005670_abnormal_white_adipose1.21406905
68MP0005332_abnormal_amino_acid1.20718220
69MP0001905_abnormal_dopamine_level1.15382854
70MP0003329_amyloid_beta_deposits1.12710369
71MP0002210_abnormal_sex_determination1.12583489
72MP0002697_abnormal_eye_size1.12328612
73MP0003656_abnormal_erythrocyte_physiolo1.11168061
74MP0009672_abnormal_birth_weight1.09142436
75MP0003787_abnormal_imprinting1.09125536
76MP0008004_abnormal_stomach_pH1.08888340
77MP0008874_decreased_physiological_sensi1.07881150
78MP0002909_abnormal_adrenal_gland1.06968139
79MP0002396_abnormal_hematopoietic_system1.04172056
80MP0002132_abnormal_respiratory_system1.03822792
81MP0001348_abnormal_lacrimal_gland1.03165226
82MP0002085_abnormal_embryonic_tissue1.01339618
83MP0005623_abnormal_meninges_morphology1.00515201
84MP0000358_abnormal_cell_content/0.98261019
85MP0001145_abnormal_male_reproductive0.98182234
86MP0004185_abnormal_adipocyte_glucose0.97235845
87MP0005423_abnormal_somatic_nervous0.96129092
88MP0005499_abnormal_olfactory_system0.95875014
89MP0005394_taste/olfaction_phenotype0.95875014
90MP0002086_abnormal_extraembryonic_tissu0.95272184
91MP0000313_abnormal_cell_death0.95093531
92MP0001545_abnormal_hematopoietic_system0.94984010
93MP0005397_hematopoietic_system_phenotyp0.94984010
94MP0002098_abnormal_vibrissa_morphology0.94612476
95MP0004084_abnormal_cardiac_muscle0.92676689
96MP0001929_abnormal_gametogenesis0.92565977
97MP0003879_abnormal_hair_cell0.90602138
98MP0005621_abnormal_cell_physiology0.90382244
99MP0002111_abnormal_tail_morphology0.88412238
100MP0005023_abnormal_wound_healing0.87474476
101MP0000653_abnormal_sex_gland0.86637115
102MP0000383_abnormal_hair_follicle0.86589765
103MP0000647_abnormal_sebaceous_gland0.85940079
104MP0005384_cellular_phenotype0.85116950
105MP0002269_muscular_atrophy0.85066663
106MP0006035_abnormal_mitochondrial_morpho0.84122692
107MP0000428_abnormal_craniofacial_morphol0.82709808
108MP0003935_abnormal_craniofacial_develop0.82015755
109MP0003937_abnormal_limbs/digits/tail_de0.81708975
110MP0003861_abnormal_nervous_system0.81099341
111MP0003941_abnormal_skin_development0.81008794
112MP0000627_abnormal_mammary_gland0.80392198
113MP0001764_abnormal_homeostasis0.80056600
114MP0002160_abnormal_reproductive_system0.79340198
115MP0002084_abnormal_developmental_patter0.78455622
116MP0006292_abnormal_olfactory_placode0.76215677
117MP0010234_abnormal_vibrissa_follicle0.76152329
118MP0001529_abnormal_vocalization0.75663727
119MP0001849_ear_inflammation0.74603701
120MP0009278_abnormal_bone_marrow0.74312837
121MP0002102_abnormal_ear_morphology0.73217552
122MP0010630_abnormal_cardiac_muscle0.73106864
123MP0005197_abnormal_uvea_morphology0.71702698
124MP0004782_abnormal_surfactant_physiolog0.71524978
125* MP0002169_no_abnormal_phenotype0.70753847
126MP0005319_abnormal_enzyme/_coenzyme0.70438776
127MP0006036_abnormal_mitochondrial_physio0.70174165
128* MP0002873_normal_phenotype0.69923186
129MP0005389_reproductive_system_phenotype0.69670980
130* MP0003699_abnormal_female_reproductive0.67415022
131MP0006138_congestive_heart_failure0.67051008
132MP0005330_cardiomyopathy0.65826843
133MP0001293_anophthalmia0.64262605
134MP0002653_abnormal_ependyma_morphology0.63811859
135MP0000609_abnormal_liver_physiology0.63741041
136MP0003646_muscle_fatigue0.63328168
137MP0009703_decreased_birth_body0.62293718
138MP0002127_abnormal_cardiovascular_syste0.61952853
139* MP0002161_abnormal_fertility/fecundity0.61327352
140MP0002163_abnormal_gland_morphology0.58592497
141MP0003828_pulmonary_edema0.56327844
142MP0002019_abnormal_tumor_incidence0.55406550
143MP0000465_gastrointestinal_hemorrhage0.55324820
144MP0005365_abnormal_bile_salt0.54995196
145MP0001727_abnormal_embryo_implantation0.54451531
146MP0001119_abnormal_female_reproductive0.54267598
147MP0000013_abnormal_adipose_tissue0.53702092
148MP0002092_abnormal_eye_morphology0.53280312
149MP0003698_abnormal_male_reproductive0.52750378
150MP0003119_abnormal_digestive_system0.49460602
151MP0000604_amyloidosis0.48719544
152MP0010678_abnormal_skin_adnexa0.48350616
153MP0000377_abnormal_hair_follicle0.48136203
154MP0003936_abnormal_reproductive_system0.48010307

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.58844200
2Hyperglycinemia (HP:0002154)5.30903391
3Fused cervical vertebrae (HP:0002949)5.00425780
4Gout (HP:0001997)4.99292822
5Cerebral hypomyelination (HP:0006808)4.92624343
6Birth length less than 3rd percentile (HP:0003561)4.68768457
7Carpal bone hypoplasia (HP:0001498)4.54793530
8Myopathic facies (HP:0002058)4.48325380
9Impulsivity (HP:0100710)4.39560940
10Entropion (HP:0000621)4.39373357
11Hyperglycinuria (HP:0003108)4.36891491
12Abnormality of abdominal situs (HP:0011620)4.35330091
13Abdominal situs inversus (HP:0003363)4.35330091
14Rough bone trabeculation (HP:0100670)4.24514200
15Bundle branch block (HP:0011710)4.07670176
16Pustule (HP:0200039)4.04451095
17Atrioventricular block (HP:0001678)3.97210495
18Abnormality of the umbilical cord (HP:0010881)3.94256630
19Asplenia (HP:0001746)3.89494852
20Progressive muscle weakness (HP:0003323)3.83242976
21Ventricular fibrillation (HP:0001663)3.77850804
22Bilateral microphthalmos (HP:0007633)3.76232698
23Abnormality of glycine metabolism (HP:0010895)3.71517479
24Abnormality of serine family amino acid metabolism (HP:0010894)3.71517479
25Aplasia/Hypoplasia of the spleen (HP:0010451)3.64387742
26Abnormal ventriculo-arterial connection (HP:0011563)3.61423712
27Transposition of the great arteries (HP:0001669)3.61423712
28Abnormal connection of the cardiac segments (HP:0011545)3.61423712
29Amelogenesis imperfecta (HP:0000705)3.60529954
30Abnormality of cells of the erythroid lineage (HP:0012130)3.59531088
31Tetraplegia (HP:0002445)3.57696277
32Ureteral duplication (HP:0000073)3.53978888
33Premature rupture of membranes (HP:0001788)3.50024750
34Abnormal number of erythroid precursors (HP:0012131)3.49263612
35Thrombocytosis (HP:0001894)3.47185519
36Abnormality of the distal phalanges of the toes (HP:0010182)3.33303608
37Aplasia/Hypoplasia of the patella (HP:0006498)3.28583396
38Delayed epiphyseal ossification (HP:0002663)3.22424553
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.21412443
40Patellar aplasia (HP:0006443)3.18769059
41Sparse lateral eyebrow (HP:0005338)3.17885280
42Short nail (HP:0001799)3.14730632
43Hypoplasia of the capital femoral epiphysis (HP:0003090)3.11599914
44Abnormal trabecular bone morphology (HP:0100671)3.11276016
45Osteolytic defects of the hand bones (HP:0009699)3.10936563
46Osteolytic defects of the phalanges of the hand (HP:0009771)3.10936563
47Muscle fiber splitting (HP:0003555)3.09046188
48Areflexia of lower limbs (HP:0002522)3.08824959
49Abnormality of serum amino acid levels (HP:0003112)3.07497355
50Segmental peripheral demyelination/remyelination (HP:0003481)3.04918012
51Aplasia/Hypoplasia of the fovea (HP:0008060)3.01686752
52Hypoplasia of the fovea (HP:0007750)3.01686752
53Aplasia/Hypoplasia involving the musculature (HP:0001460)2.98849795
54CNS hypomyelination (HP:0003429)2.95802469
55Secondary amenorrhea (HP:0000869)2.93515710
56Premature ovarian failure (HP:0008209)2.93372605
57Megaloblastic anemia (HP:0001889)2.90927101
58Submucous cleft hard palate (HP:0000176)2.87134976
59Death in infancy (HP:0001522)2.85978931
60Metaphyseal cupping (HP:0003021)2.83927161
61Delusions (HP:0000746)2.82081984
62Glucose intolerance (HP:0000833)2.81864247
63Congenital, generalized hypertrichosis (HP:0004540)2.80457998
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80251270
65Reticulocytopenia (HP:0001896)2.72937915
66Abnormality of pyrimidine metabolism (HP:0004353)2.71095287
67Alopecia of scalp (HP:0002293)2.69592686
68Ileus (HP:0002595)2.68108346
69Short clavicles (HP:0000894)2.66732588
70Irregular epiphyses (HP:0010582)2.65899249
71Trismus (HP:0000211)2.65351629
72Personality changes (HP:0000751)2.63919694
73Absent hand (HP:0004050)2.61413101
74Small epiphyses (HP:0010585)2.59240299
75Abnormal umbilical cord blood vessels (HP:0011403)2.58524891
76Single umbilical artery (HP:0001195)2.58524891
77Abnormality of the fetal cardiovascular system (HP:0010948)2.58524891
78Absent radius (HP:0003974)2.57780250
79Microvesicular hepatic steatosis (HP:0001414)2.57025942
80Multiple enchondromatosis (HP:0005701)2.55324195
81Heart block (HP:0012722)2.53011075
82Abnormalities of placenta or umbilical cord (HP:0001194)2.51478747
83Abnormality of alanine metabolism (HP:0010916)2.49014946
84Hyperalaninemia (HP:0003348)2.49014946
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49014946
86Stillbirth (HP:0003826)2.48098909
87Prolonged neonatal jaundice (HP:0006579)2.42813641
88Abnormal spermatogenesis (HP:0008669)2.42725578
89Aplasia/Hypoplasia of the macula (HP:0008059)2.42714017
90Abnormality of the labia minora (HP:0012880)2.42365798
91Absent epiphyses (HP:0010577)2.42334621
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.42334621
93Absent forearm bone (HP:0003953)2.41852985
94Aplasia involving forearm bones (HP:0009822)2.41852985
95Dysautonomia (HP:0002459)2.41551244
96Pelvic girdle muscle weakness (HP:0003749)2.41107674
97Flat capital femoral epiphysis (HP:0003370)2.39399963
98Hyperuricemia (HP:0002149)2.39031724
99Increased purine levels (HP:0004368)2.39031724
100Hypergonadotropic hypogonadism (HP:0000815)2.38853518
101Reduced subcutaneous adipose tissue (HP:0003758)2.38235827
102Sparse eyelashes (HP:0000653)2.37300824
103Abnormality of the proximal phalanges of the hand (HP:0009834)2.36900026
104Abnormal atrioventricular conduction (HP:0005150)2.36260442
105Ragged-red muscle fibers (HP:0003200)2.35412895
106Degeneration of anterior horn cells (HP:0002398)2.31569105
107Abnormality of the anterior horn cell (HP:0006802)2.31569105
108Shoulder girdle muscle weakness (HP:0003547)2.31243377
109Restlessness (HP:0000711)2.30758281
110Aplasia/Hypoplasia of the clavicles (HP:0006710)2.30669286
111Global brain atrophy (HP:0002283)2.30129756
112Brittle hair (HP:0002299)2.29823072
113Osteomalacia (HP:0002749)2.28935225
114Abnormality of the fovea (HP:0000493)2.28220276
115Abnormality of the vocal cords (HP:0008777)2.24848498
116Oligodactyly (hands) (HP:0001180)2.22772083
117Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22753287
118Choanal stenosis (HP:0000452)2.21961724
119Difficulty climbing stairs (HP:0003551)2.19713742
120External ophthalmoplegia (HP:0000544)2.19285021
121Hyperglycemia (HP:0003074)2.18996453
122Patent foramen ovale (HP:0001655)2.18538749
123Aplasia of the musculature (HP:0100854)2.18492892
124Mutism (HP:0002300)2.15028673
125Pancreatic fibrosis (HP:0100732)2.14635470
126Facial cleft (HP:0002006)2.11953793
127Impaired proprioception (HP:0010831)2.08522349
128Natal tooth (HP:0000695)2.07939525
129Abnormal tarsal ossification (HP:0008369)2.06043513
130Vertebral fusion (HP:0002948)2.05400088
131Spinal muscular atrophy (HP:0007269)2.05139534
132Split foot (HP:0001839)2.03820091
133Abnormality of the hip-girdle musculature (HP:0001445)2.03414072
134Abnormality of the musculature of the pelvis (HP:0001469)2.03414072
135Insulin-resistant diabetes mellitus (HP:0000831)2.03329085
136Abnormality of dental color (HP:0011073)2.02578441
137Horseshoe kidney (HP:0000085)2.02065884
138Hypercortisolism (HP:0001578)2.01919424
139Microretrognathia (HP:0000308)2.01298852
140Dysphonia (HP:0001618)2.01156712
141Tongue fasciculations (HP:0001308)2.00670436
142High anterior hairline (HP:0009890)1.99422655
143CNS demyelination (HP:0007305)1.97982558
144Hypoplasia of the radius (HP:0002984)1.95933947
145Gastrointestinal stroma tumor (HP:0100723)1.94788991
146Male infertility (HP:0003251)1.93810027
147Postnatal microcephaly (HP:0005484)1.93305490
148Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93034351
149Partial duplication of thumb phalanx (HP:0009944)1.92705008
150Stenosis of the external auditory canal (HP:0000402)1.92573451
151Muscle fibrillation (HP:0010546)1.92538282
152Abnormality of magnesium homeostasis (HP:0004921)1.92452477
153Poor suck (HP:0002033)1.91936230
154Breast aplasia (HP:0100783)1.90886731
155Reduced antithrombin III activity (HP:0001976)1.90538956
156Genu recurvatum (HP:0002816)1.90007958
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88949380
158Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88949380
159Broad distal phalanx of finger (HP:0009836)1.87964270
160Malnutrition (HP:0004395)1.87732778
161Methylmalonic aciduria (HP:0012120)1.87020769
162Partial duplication of the phalanx of hand (HP:0009999)1.86359152
163Diaphragmatic weakness (HP:0009113)1.86223493
164Nasolacrimal duct obstruction (HP:0000579)1.84531467
165Duplication of thumb phalanx (HP:0009942)1.84421129
166Tinnitus (HP:0000360)1.81557436
167Abnormality of carpal bone ossification (HP:0006257)1.78804915
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74112422
169Ectopic anus (HP:0004397)1.73598720
170Abnormality of the aortic arch (HP:0012303)1.72429227
171Premature skin wrinkling (HP:0100678)1.71579250
172Hypoplastic pelvis (HP:0008839)1.68822441
173Persistence of primary teeth (HP:0006335)1.67864412
174Insulin resistance (HP:0000855)1.67472830
175Cleft eyelid (HP:0000625)1.67142656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.48382242
2BUB17.50214558
3PBK6.27929699
4AKT35.62830095
5PHKG24.56864442
6PHKG14.56864442
7WEE14.52635637
8TSSK64.23818775
9SMG14.19740501
10PLK43.06170752
11EPHA22.85148106
12NEK22.67820696
13BRSK22.47376513
14EIF2AK12.37453081
15EEF2K2.34404329
16STK162.33113920
17ZAK2.16916809
18PLK31.98747784
19BRSK11.88663725
20TTK1.88048977
21BMX1.87767383
22IRAK31.86098034
23PRPF4B1.80853305
24PNCK1.80598692
25ICK1.78110446
26PLK11.74742190
27NEK11.72830175
28PDK41.68161805
29PDK31.68161805
30ACVR1B1.61488295
31WNK41.56171219
32SRPK11.55416805
33PINK11.55099421
34NME21.53160118
35MKNK21.50598416
36ARAF1.50142685
37STK391.49868008
38CCNB11.47571435
39PRKG21.43705321
40PDK21.41706795
41EIF2AK31.40809239
42VRK21.34544287
43DYRK31.30074617
44MKNK11.27308866
45STK31.24225025
46BRAF1.21541029
47CHEK21.20273649
48OXSR11.18811075
49CDK191.18789066
50PAK41.02228610
51AURKA1.01136370
52PIM20.99026094
53AURKB0.98765042
54TAOK20.97170763
55LATS20.93861221
56TESK20.91033999
57CSNK1G30.90940654
58KDR0.89479659
59FGFR40.85273553
60ALK0.84479177
61RPS6KA20.82253843
62MAP3K80.78064178
63PRKCI0.77340015
64CDK120.76410047
65PAK10.74314328
66CDC70.72786330
67CSNK1A1L0.72221489
68CHEK10.68621890
69CSF1R0.67685246
70CDK70.67666481
71CAMKK20.66979193
72MAP3K90.66676811
73CDK40.66512470
74CSNK1G10.65921202
75RPS6KA40.64511742
76MAP3K60.63784994
77RPS6KC10.63004756
78RPS6KL10.63004756
79STK38L0.60386922
80CSNK1G20.60081849
81EIF2AK20.59368270
82TESK10.59102751
83MAP3K140.59028995
84RPS6KA10.56913757
85MARK10.56518730
86DMPK0.53299819
87TRIB30.52718328
88CDK20.52124245
89ATR0.51374014
90BCKDK0.50813951
91MAPK110.50291178
92RPS6KA60.50040691
93RAF10.50039357
94CSNK1E0.47397052
95PRKAA10.46151622
96RIPK10.46102577
97NME10.46003112
98PRKCG0.45885502
99MAP3K10.44658582
100STK240.43008999
101CDK30.41564778
102VRK10.39707050
103PASK0.39173199
104LRRK20.39067324
105CSNK2A10.38123238
106CDK10.37300822
107CSNK2A20.36655923
108MAP2K20.33070247
109PIM10.32366341
110WNK30.32237596
111CSNK1A10.31693955
112STK100.29286255
113DAPK30.28662429
114KSR20.27808378
115FGFR20.26882714
116PRKD30.26741341
117FGR0.26075955
118MELK0.25905040
119CHUK0.25468991
120AKT20.21862201
121DYRK20.21788383
122SIK10.21737541
123ATM0.21553149
124MTOR0.21457647
125ROCK20.21339085
126CAMK40.21007212
127PAK60.20681980
128STK380.20363226
129MAP3K30.20198549
130CDK80.19421209
131ABL20.19249188
132PRKCZ0.19062826
133RPS6KB20.19005149
134STK40.18336141
135RPS6KA50.18020272
136TYRO30.17665000
137ILK0.17276121
138EPHA40.15767903
139MAPK90.15140495
140PKN10.14350123
141MAP2K60.13618282
142TAOK10.13312108
143MAPK40.11622611
144MAPK100.10679783
145TLK10.10088315
146PAK20.09721657
147PDPK10.08340207
148NEK60.07662073
149PAK30.06402400
150CAMK2G0.06257980
151GSK3B0.05990519
152RIPK40.04964248
153MAP2K10.03971609

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007508.30944349
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.21182507
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38422486
4RNA polymerase_Homo sapiens_hsa030204.30620959
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.45412466
6Proteasome_Homo sapiens_hsa030503.43795357
7Regulation of autophagy_Homo sapiens_hsa041403.01096802
8RNA transport_Homo sapiens_hsa030132.90138532
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.69845197
10Glycerophospholipid metabolism_Homo sapiens_hsa005642.51450630
11Vitamin digestion and absorption_Homo sapiens_hsa049772.49228815
12Pyrimidine metabolism_Homo sapiens_hsa002402.32791792
13Cell cycle_Homo sapiens_hsa041102.29309136
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26606459
15DNA replication_Homo sapiens_hsa030302.02174298
16Spliceosome_Homo sapiens_hsa030402.01058500
17p53 signaling pathway_Homo sapiens_hsa041151.81628508
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.79973537
19Pentose phosphate pathway_Homo sapiens_hsa000301.79212060
20Basal transcription factors_Homo sapiens_hsa030221.72019629
21Purine metabolism_Homo sapiens_hsa002301.71532466
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70158901
23Base excision repair_Homo sapiens_hsa034101.70108488
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62985961
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.57822968
26Mismatch repair_Homo sapiens_hsa034301.48238310
27Nucleotide excision repair_Homo sapiens_hsa034201.46371033
28Homologous recombination_Homo sapiens_hsa034401.44607330
29Oocyte meiosis_Homo sapiens_hsa041141.39286613
30Basal cell carcinoma_Homo sapiens_hsa052171.38250803
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29009851
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28114396
33Biosynthesis of amino acids_Homo sapiens_hsa012301.27243034
34Oxidative phosphorylation_Homo sapiens_hsa001901.14027125
35Epstein-Barr virus infection_Homo sapiens_hsa051691.13881255
36Melanoma_Homo sapiens_hsa052181.13035224
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12912932
38N-Glycan biosynthesis_Homo sapiens_hsa005101.11543065
39Huntingtons disease_Homo sapiens_hsa050161.09463096
40Arginine biosynthesis_Homo sapiens_hsa002201.05346495
41Fructose and mannose metabolism_Homo sapiens_hsa000511.03570602
42Ribosome_Homo sapiens_hsa030101.02571764
43Circadian rhythm_Homo sapiens_hsa047101.00341819
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96250763
45Parkinsons disease_Homo sapiens_hsa050120.95465673
46Sulfur relay system_Homo sapiens_hsa041220.95326072
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94058955
48Fanconi anemia pathway_Homo sapiens_hsa034600.93911800
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91258709
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.86650844
51Vibrio cholerae infection_Homo sapiens_hsa051100.86463175
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80296188
53Cardiac muscle contraction_Homo sapiens_hsa042600.79963662
54Lysosome_Homo sapiens_hsa041420.79582267
55Glycerolipid metabolism_Homo sapiens_hsa005610.78960954
56One carbon pool by folate_Homo sapiens_hsa006700.74822661
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72240060
58Fatty acid biosynthesis_Homo sapiens_hsa000610.70731787
59Carbon metabolism_Homo sapiens_hsa012000.66997835
60Renin-angiotensin system_Homo sapiens_hsa046140.65825278
61RNA degradation_Homo sapiens_hsa030180.65467039
62Wnt signaling pathway_Homo sapiens_hsa043100.63396306
63Insulin signaling pathway_Homo sapiens_hsa049100.62767508
64Synaptic vesicle cycle_Homo sapiens_hsa047210.61440696
65Butanoate metabolism_Homo sapiens_hsa006500.61437510
66Selenocompound metabolism_Homo sapiens_hsa004500.60209217
67Antigen processing and presentation_Homo sapiens_hsa046120.60130822
68mRNA surveillance pathway_Homo sapiens_hsa030150.59619291
69Glucagon signaling pathway_Homo sapiens_hsa049220.58030711
70* Metabolic pathways_Homo sapiens_hsa011000.54732316
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51207309
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51045013
73MAPK signaling pathway_Homo sapiens_hsa040100.47121383
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46847740
75Mineral absorption_Homo sapiens_hsa049780.44832852
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44130809
77mTOR signaling pathway_Homo sapiens_hsa041500.43971961
78* Folate biosynthesis_Homo sapiens_hsa007900.43927722
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41498788
80MicroRNAs in cancer_Homo sapiens_hsa052060.39763245
81Glutathione metabolism_Homo sapiens_hsa004800.39567452
82Notch signaling pathway_Homo sapiens_hsa043300.38027615
83Inositol phosphate metabolism_Homo sapiens_hsa005620.38010819
84Pyruvate metabolism_Homo sapiens_hsa006200.37360004
85Arginine and proline metabolism_Homo sapiens_hsa003300.37223612
86Sphingolipid metabolism_Homo sapiens_hsa006000.36116646
87FoxO signaling pathway_Homo sapiens_hsa040680.35577871
88Pathways in cancer_Homo sapiens_hsa052000.33490767
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.32522106
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31010175
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30612913
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.30507150
93Rap1 signaling pathway_Homo sapiens_hsa040150.30073022
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29208906
95Insulin resistance_Homo sapiens_hsa049310.27697746
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25879273
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25139226
98Galactose metabolism_Homo sapiens_hsa000520.24954158
99Alzheimers disease_Homo sapiens_hsa050100.24420849
100Viral carcinogenesis_Homo sapiens_hsa052030.23443327
101Retinol metabolism_Homo sapiens_hsa008300.23390421
102Collecting duct acid secretion_Homo sapiens_hsa049660.23068014
103Linoleic acid metabolism_Homo sapiens_hsa005910.22928005
104Prion diseases_Homo sapiens_hsa050200.19147882
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16496523
106beta-Alanine metabolism_Homo sapiens_hsa004100.15023438
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13703498
108Steroid biosynthesis_Homo sapiens_hsa001000.12837814
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12498949
110Herpes simplex infection_Homo sapiens_hsa051680.11365062
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10048226
112Non-homologous end-joining_Homo sapiens_hsa034500.09116727
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08704355
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07887232
115HIF-1 signaling pathway_Homo sapiens_hsa040660.07863679
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.07435534
117Renal cell carcinoma_Homo sapiens_hsa052110.06662519
118Arachidonic acid metabolism_Homo sapiens_hsa005900.06073384
119Hippo signaling pathway_Homo sapiens_hsa043900.05130689
120Fatty acid metabolism_Homo sapiens_hsa012120.03721855
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03704579
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03132925
123HTLV-I infection_Homo sapiens_hsa051660.01807760
124Hedgehog signaling pathway_Homo sapiens_hsa043400.01506751
125Fatty acid elongation_Homo sapiens_hsa000620.01058958
126Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0212046
127Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0208983
128AMPK signaling pathway_Homo sapiens_hsa04152-0.0183896
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0171767
130Apoptosis_Homo sapiens_hsa04210-0.0169782
131Tight junction_Homo sapiens_hsa04530-0.0151083
132Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0123943
133Ether lipid metabolism_Homo sapiens_hsa00565-0.0050104
134Small cell lung cancer_Homo sapiens_hsa05222-0.0046977
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0032999
136Fat digestion and absorption_Homo sapiens_hsa04975-0.0031416

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