ALS2CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.37970885
2desmosome organization (GO:0002934)9.34492708
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.18954344
4establishment of skin barrier (GO:0061436)5.89465888
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.89460681
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.89460681
7regulation of water loss via skin (GO:0033561)5.75150821
8regulation of gamma-delta T cell differentiation (GO:0045586)5.16203426
9positive thymic T cell selection (GO:0045059)4.97600253
10antigen processing and presentation of endogenous antigen (GO:0019883)4.89353627
11negative T cell selection (GO:0043383)4.87130909
12cell-substrate junction assembly (GO:0007044)4.86210091
13multicellular organismal water homeostasis (GO:0050891)4.78033856
14keratinocyte proliferation (GO:0043616)4.75943255
15positive T cell selection (GO:0043368)4.73868083
16surfactant homeostasis (GO:0043129)4.70273949
17positive regulation of gamma-delta T cell activation (GO:0046645)4.65844417
18regulation of gamma-delta T cell activation (GO:0046643)4.65233464
19negative thymic T cell selection (GO:0045060)4.62743125
20thymic T cell selection (GO:0045061)4.60555597
21T cell selection (GO:0045058)4.48320622
22keratinization (GO:0031424)4.30903853
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26009432
24negative regulation of cell killing (GO:0031342)4.26009432
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04786774
26water homeostasis (GO:0030104)3.90962803
27atrioventricular valve morphogenesis (GO:0003181)3.66343577
28chemical homeostasis within a tissue (GO:0048875)3.63096829
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57092078
30alpha-linolenic acid metabolic process (GO:0036109)3.56408328
31regulation of T cell tolerance induction (GO:0002664)3.52913528
32interferon-gamma production (GO:0032609)3.52860309
33keratinocyte differentiation (GO:0030216)3.52662959
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49751908
35L-phenylalanine catabolic process (GO:0006559)3.49751908
36L-phenylalanine metabolic process (GO:0006558)3.44490897
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44490897
38regulation of cholesterol homeostasis (GO:2000188)3.42652591
39epithelial cell-cell adhesion (GO:0090136)3.42270259
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39922117
41epithelial cell differentiation involved in prostate gland development (GO:0060742)3.34989696
42urea metabolic process (GO:0019627)3.31349002
43urea cycle (GO:0000050)3.31349002
44peptide cross-linking (GO:0018149)3.30497604
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.29175498
46regulation of endothelial cell chemotaxis (GO:2001026)3.28293128
47T cell receptor signaling pathway (GO:0050852)3.27661020
48aromatic amino acid family catabolic process (GO:0009074)3.24621932
49negative regulation of fibrinolysis (GO:0051918)3.21093610
50response to interleukin-15 (GO:0070672)3.20578337
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20341229
52kynurenine metabolic process (GO:0070189)3.16053562
53valine metabolic process (GO:0006573)3.12602181
54indole-containing compound catabolic process (GO:0042436)3.12040720
55indolalkylamine catabolic process (GO:0046218)3.12040720
56tryptophan catabolic process (GO:0006569)3.12040720
57semaphorin-plexin signaling pathway (GO:0071526)3.12005287
58phospholipid efflux (GO:0033700)3.09882659
59positive regulation of Cdc42 GTPase activity (GO:0043089)3.09530863
60complement activation, alternative pathway (GO:0006957)3.06351152
61positive regulation of tolerance induction (GO:0002645)3.05680792
62cell-substrate adherens junction assembly (GO:0007045)3.03948948
63focal adhesion assembly (GO:0048041)3.03948948
64negative regulation of keratinocyte proliferation (GO:0010839)2.99558801
65epidermis development (GO:0008544)2.97192290
66gap junction assembly (GO:0016264)2.97051850
67bile acid biosynthetic process (GO:0006699)2.96163255
68renal filtration (GO:0097205)2.95889161
69intermediate filament organization (GO:0045109)2.95442363
70T cell migration (GO:0072678)2.91933202
71positive regulation of humoral immune response (GO:0002922)2.91828654
72ethanol oxidation (GO:0006069)2.91340175
73nitrogen cycle metabolic process (GO:0071941)2.91253512
74positive regulation of histone deacetylation (GO:0031065)2.91192930
75epidermal cell differentiation (GO:0009913)2.90791961
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.90452596
77regulation of fibrinolysis (GO:0051917)2.89460619
78endothelial cell chemotaxis (GO:0035767)2.88674645
79regulation of triglyceride catabolic process (GO:0010896)2.88627894
80regulation of protein activation cascade (GO:2000257)2.88440426
81tryptophan metabolic process (GO:0006568)2.88007064
82phospholipid homeostasis (GO:0055091)2.87240172
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86813260
84protein localization to endosome (GO:0036010)2.86485454
85negative regulation of sterol transport (GO:0032372)2.85915831
86negative regulation of cholesterol transport (GO:0032375)2.85915831
87hypotonic response (GO:0006971)2.85753422
88T cell costimulation (GO:0031295)2.84296013
89protein carboxylation (GO:0018214)2.83626167
90peptidyl-glutamic acid carboxylation (GO:0017187)2.83626167
91regulation of isotype switching to IgG isotypes (GO:0048302)2.82369075
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82045892
93cysteine metabolic process (GO:0006534)2.82018683
94adherens junction assembly (GO:0034333)2.81390382
95positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.80037616
96activation of Rac GTPase activity (GO:0032863)2.79483333
97lymphocyte costimulation (GO:0031294)2.78173999
98molting cycle (GO:0042303)2.76272023
99hair cycle (GO:0042633)2.76272023
100morphogenesis of an endothelium (GO:0003159)2.75951426
101endothelial tube morphogenesis (GO:0061154)2.75951426
102response to laminar fluid shear stress (GO:0034616)2.74632922
103regulation of response to interferon-gamma (GO:0060330)2.74395922
104high-density lipoprotein particle remodeling (GO:0034375)2.73148531
105regulation of complement activation (GO:0030449)2.71946429
106lysine catabolic process (GO:0006554)2.68227443
107lysine metabolic process (GO:0006553)2.68227443
108regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.68074929
109glyoxylate metabolic process (GO:0046487)2.67596637
110negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67543044
111positive regulation of interleukin-2 production (GO:0032743)2.66975364
112sulfur amino acid catabolic process (GO:0000098)2.66191213
113regulation of extracellular matrix disassembly (GO:0010715)2.65168949
114amino-acid betaine metabolic process (GO:0006577)2.65014071
115ventricular cardiac muscle cell action potential (GO:0086005)2.64284440
116homocysteine metabolic process (GO:0050667)2.64171613
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62211854
118negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60889221
119positive regulation of epidermis development (GO:0045684)2.60876375
120regulation of ruffle assembly (GO:1900027)2.60601076
121regulation of interleukin-2 biosynthetic process (GO:0045076)2.59913251
1222-oxoglutarate metabolic process (GO:0006103)2.59907313
123cell adhesion mediated by integrin (GO:0033627)2.58335188
124positive regulation of epidermal cell differentiation (GO:0045606)2.56994230
125regulation of tolerance induction (GO:0002643)2.56018647
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55379279
127leukocyte aggregation (GO:0070486)2.54852606
128mannose metabolic process (GO:0006013)2.54038497
129regulation of transforming growth factor beta2 production (GO:0032909)2.53998530
130bile acid metabolic process (GO:0008206)2.53138576
131cell migration involved in sprouting angiogenesis (GO:0002042)2.52461562
132negative regulation of erythrocyte differentiation (GO:0045647)2.51689627
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51268567
134plasma lipoprotein particle assembly (GO:0034377)2.50988622
135reverse cholesterol transport (GO:0043691)2.50713629
136antigen receptor-mediated signaling pathway (GO:0050851)2.50483860
137alpha-beta T cell differentiation (GO:0046632)2.49473639
138positive regulation of receptor recycling (GO:0001921)2.48579689
139skin morphogenesis (GO:0043589)2.48436467
140alpha-beta T cell activation (GO:0046631)2.46307997
141triglyceride homeostasis (GO:0070328)2.46283319
142acylglycerol homeostasis (GO:0055090)2.46283319
143blood vessel endothelial cell migration (GO:0043534)2.45922011
144regulation of keratinocyte proliferation (GO:0010837)2.45645061
145plasma membrane repair (GO:0001778)2.45088195
146regulation of regulatory T cell differentiation (GO:0045589)2.44653430
147cell junction assembly (GO:0034329)2.42192224
148regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41533118
149serine family amino acid catabolic process (GO:0009071)2.40984477
150dicarboxylic acid biosynthetic process (GO:0043650)2.40916070
151positive regulation of triglyceride metabolic process (GO:0090208)2.40296386
152cell junction organization (GO:0034330)2.38403958
153regulation of keratinocyte differentiation (GO:0045616)2.37426438
154regulation of p38MAPK cascade (GO:1900744)2.36119624
155cholesterol homeostasis (GO:0042632)2.35803396
156negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34231226
157regulation of transforming growth factor beta1 production (GO:0032908)2.33790851
158positive regulation of keratinocyte differentiation (GO:0045618)2.33187283
159cell volume homeostasis (GO:0006884)2.33171119
160apoptotic process involved in morphogenesis (GO:0060561)2.32203430
161filopodium assembly (GO:0046847)2.31407508
162negative regulation of stress fiber assembly (GO:0051497)2.30959227
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30882970
164keratinocyte development (GO:0003334)2.27599446
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27189398
166mesodermal cell differentiation (GO:0048333)2.26688038
167positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25666555
168negative regulation of fatty acid transport (GO:2000192)2.25494492
169negative regulation of interleukin-2 production (GO:0032703)2.25084162
170polarized epithelial cell differentiation (GO:0030859)2.23680781
171regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.22739038
172negative regulation of myotube differentiation (GO:0010832)2.20957822
173negative regulation of protein tyrosine kinase activity (GO:0061099)2.19339240
174positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.19098166
175Rho protein signal transduction (GO:0007266)2.18890168
176establishment of planar polarity (GO:0001736)2.18480814
177establishment of tissue polarity (GO:0007164)2.18480814
178vascular endothelial growth factor signaling pathway (GO:0038084)2.18029655
179regulation of necroptotic process (GO:0060544)2.17868731
180cell communication involved in cardiac conduction (GO:0086065)2.16482001
181detection of bacterium (GO:0016045)2.15636210
182cell-cell junction assembly (GO:0007043)2.14594739
183cell junction maintenance (GO:0034331)2.14490384
184glomerular filtration (GO:0003094)2.14164786
185regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.12928169
186endocytic recycling (GO:0032456)2.11447025
187regulation of hair cycle (GO:0042634)2.11381135
188regulation of cardioblast differentiation (GO:0051890)2.10895831
189regulation of anoikis (GO:2000209)2.10502063
190regulation of Cdc42 GTPase activity (GO:0043088)2.10368404
191phospholipid scrambling (GO:0017121)2.09620742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06115627
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.84419166
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.27458201
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.74480734
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61054278
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.22394329
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.14985535
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11665223
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.08497746
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00837072
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76982589
12RUNX_20019798_ChIP-Seq_JUKART_Human2.62260120
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54690540
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.52695747
15MYC_22102868_ChIP-Seq_BL_Human2.32138575
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29780879
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26665570
18* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25661584
19* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16602949
20MAF_26560356_Chip-Seq_TH1_Human2.10002452
21CLOCK_20551151_ChIP-Seq_293T_Human2.03797118
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97416705
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.97052295
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90814091
25UTX_26944678_Chip-Seq_JUKART_Human1.87802696
26TCF7_22412390_ChIP-Seq_EML_Mouse1.87746262
27MYB_26560356_Chip-Seq_TH2_Human1.84947587
28MYB_26560356_Chip-Seq_TH1_Human1.80041539
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79939017
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77164965
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73551433
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73470930
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71881789
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71424675
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.70578373
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68062332
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68009823
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67218237
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65002460
40VDR_21846776_ChIP-Seq_THP-1_Human1.64910998
41KDM2B_26808549_Chip-Seq_DND41_Human1.63508951
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.61826879
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61566927
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58229623
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.54001832
46GATA1_22025678_ChIP-Seq_K562_Human1.52484288
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52474952
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51591210
49* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50864709
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50802777
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.50522976
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49514756
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.45999969
54* TP63_22573176_ChIP-Seq_HFKS_Human1.45342449
55ATF3_27146783_Chip-Seq_COLON_Human1.44087854
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42036423
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39831579
58KLF5_25053715_ChIP-Seq_YYC3_Human1.38361940
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.37500483
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37491898
61MAF_26560356_Chip-Seq_TH2_Human1.37449804
62SOX2_20726797_ChIP-Seq_SW620_Human1.37338689
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37336216
64SCL_19346495_ChIP-Seq_HPC-7_Human1.35782246
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.35012765
66KDM2B_26808549_Chip-Seq_K562_Human1.34376531
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32771549
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.32286740
69GATA3_27048872_Chip-Seq_THYMUS_Human1.30692421
70* SMC4_20622854_ChIP-Seq_HELA_Human1.30155415
71RACK7_27058665_Chip-Seq_MCF-7_Human1.28995618
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26851638
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26461243
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.25937829
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.24309261
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23384000
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21893968
78CTCF_27219007_Chip-Seq_Bcells_Human1.19602882
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.19299861
80* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18687404
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.17877999
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.17216424
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17173230
84LXR_22292898_ChIP-Seq_THP-1_Human1.16633672
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15139067
86VDR_24763502_ChIP-Seq_THP-1_Human1.14284011
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12959386
88CREB1_26743006_Chip-Seq_LNCaP_Human1.12702984
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11620802
90GATA1_19941826_ChIP-Seq_K562_Human1.11529865
91* P68_20966046_ChIP-Seq_HELA_Human1.11009617
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09758065
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07908839
94ZNF263_19887448_ChIP-Seq_K562_Human1.07481326
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06812235
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05611680
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.05331733
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.04721332
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04475707
100GATA2_19941826_ChIP-Seq_K562_Human1.03593591
101NCOR1_26117541_ChIP-Seq_K562_Human1.02561716
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02272416
103GATA6_25053715_ChIP-Seq_YYC3_Human1.01405121
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00157162
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99180527
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98900440
107GATA4_25053715_ChIP-Seq_YYC3_Human0.98883216
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98573897
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98171892
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97056469
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96508607
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96508607
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.96069316
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.96069316
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95961474
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95425900
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95183975
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95002056
119SPI1_23127762_ChIP-Seq_K562_Human0.94570646
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94523174
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93781255
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93710658
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93561835
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93197473
125BCOR_27268052_Chip-Seq_Bcells_Human0.92918415
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92813599
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91973637
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91537325
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91348698
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.91056948
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90066946
132* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89669014
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88906206
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.88528538
135TP63_23658742_ChIP-Seq_EP156T_Human0.88280308
136TP53_22127205_ChIP-Seq_IMR90_Human0.88054842
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.87700867
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87615492
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86785627
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85211768
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84967777
142* TET1_21490601_ChIP-Seq_MESCs_Mouse0.83449379
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83117831
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82474208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.65061282
2MP0005360_urolithiasis3.93111951
3MP0002139_abnormal_hepatobiliary_system3.92244741
4MP0003763_abnormal_thymus_physiology3.52435667
5MP0005365_abnormal_bile_salt3.48962195
6MP0005085_abnormal_gallbladder_physiolo3.08225421
7MP0002138_abnormal_hepatobiliary_system2.78020083
8MP0000566_synostosis2.74730401
9MP0005275_abnormal_skin_tensile2.71483107
10MP0003252_abnormal_bile_duct2.50069483
11MP0008875_abnormal_xenobiotic_pharmacok2.45128704
12MP0000467_abnormal_esophagus_morphology2.43384726
13MP0004264_abnormal_extraembryonic_tissu2.41935672
14MP0000685_abnormal_immune_system2.37344656
15MP0002098_abnormal_vibrissa_morphology2.31026276
16MP0010678_abnormal_skin_adnexa2.24479209
17MP0005409_darkened_coat_color2.20726015
18MP0003300_gastrointestinal_ulcer2.19715936
19MP0002166_altered_tumor_susceptibility2.18173821
20MP0004782_abnormal_surfactant_physiolog2.17980751
21MP0003191_abnormal_cellular_cholesterol2.07231838
22MP0001849_ear_inflammation2.06261911
23MP0000762_abnormal_tongue_morphology2.05806662
24MP0009840_abnormal_foam_cell2.04786338
25MP0003724_increased_susceptibility_to2.00557205
26MP0010329_abnormal_lipoprotein_level1.96496070
27MP0004947_skin_inflammation1.92649223
28MP0005083_abnormal_biliary_tract1.91574683
29MP0003436_decreased_susceptibility_to1.88838244
30MP0000383_abnormal_hair_follicle1.87946181
31MP0003941_abnormal_skin_development1.83354492
32MP0000609_abnormal_liver_physiology1.74471744
33MP0002254_reproductive_system_inflammat1.73411541
34MP0001666_abnormal_nutrient_absorption1.72165382
35MP0001873_stomach_inflammation1.68162543
36MP0003705_abnormal_hypodermis_morpholog1.67951023
37MP0010155_abnormal_intestine_physiology1.67630801
38MP0009780_abnormal_chondrocyte_physiolo1.66738265
39MP0002006_tumorigenesis1.64566688
40MP0010771_integument_phenotype1.64131227
41MP0005670_abnormal_white_adipose1.59423934
42MP0001835_abnormal_antigen_presentation1.58260903
43MP0001790_abnormal_immune_system1.57800562
44MP0005387_immune_system_phenotype1.57800562
45MP0000377_abnormal_hair_follicle1.57123461
46MP0004272_abnormal_basement_membrane1.55502064
47MP0001800_abnormal_humoral_immune1.54829173
48MP0010234_abnormal_vibrissa_follicle1.53974150
49MP0005464_abnormal_platelet_physiology1.49505439
50MP0004185_abnormal_adipocyte_glucose1.49183934
51MP0010368_abnormal_lymphatic_system1.47680535
52MP0004381_abnormal_hair_follicle1.44641387
53MP0000751_myopathy1.44578371
54MP0009785_altered_susceptibility_to1.42619253
55MP0006138_congestive_heart_failure1.40012066
56MP0005671_abnormal_response_to1.39917580
57MP0002723_abnormal_immune_serum1.38144025
58MP0005025_abnormal_response_to1.38004715
59MP0001853_heart_inflammation1.35178384
60MP0001958_emphysema1.33359127
61MP0003453_abnormal_keratinocyte_physiol1.32859760
62MP0002405_respiratory_system_inflammati1.32616851
63MP0002420_abnormal_adaptive_immunity1.32142648
64MP0002796_impaired_skin_barrier1.31738592
65MP0001819_abnormal_immune_cell1.30872656
66MP0010352_gastrointestinal_tract_polyps1.30508672
67MP0000678_abnormal_parathyroid_gland1.30050167
68MP0003303_peritoneal_inflammation1.30014184
69MP0003866_abnormal_defecation1.29744931
70MP0008961_abnormal_basal_metabolism1.28946791
71MP0003566_abnormal_cell_adhesion1.28880246
72MP0009931_abnormal_skin_appearance1.28706922
73MP0005076_abnormal_cell_differentiation1.28201439
74MP0005023_abnormal_wound_healing1.28126772
75MP0000703_abnormal_thymus_morphology1.27673330
76MP0003806_abnormal_nucleotide_metabolis1.25637112
77MP0005000_abnormal_immune_tolerance1.24854834
78MP0002398_abnormal_bone_marrow1.23551861
79MP0003091_abnormal_cell_migration1.22888128
80MP0001851_eye_inflammation1.22632491
81MP0009278_abnormal_bone_marrow1.22027850
82MP0005375_adipose_tissue_phenotype1.21380025
83MP0002452_abnormal_antigen_presenting1.20247044
84MP0002118_abnormal_lipid_homeostasis1.19207955
85MP0000013_abnormal_adipose_tissue1.19124470
86MP0000003_abnormal_adipose_tissue1.18828671
87MP0008260_abnormal_autophagy1.16705065
88MP0006082_CNS_inflammation1.16353906
89MP0009643_abnormal_urine_homeostasis1.16350308
90MP0009333_abnormal_splenocyte_physiolog1.15435336
91MP0004084_abnormal_cardiac_muscle1.15222248
92MP0002722_abnormal_immune_system1.14731343
93MP0001845_abnormal_inflammatory_respons1.14612180
94MP0005332_abnormal_amino_acid1.14326546
95MP0000716_abnormal_immune_system1.14231491
96MP0005666_abnormal_adipose_tissue1.12940176
97MP0003828_pulmonary_edema1.12289606
98MP0002396_abnormal_hematopoietic_system1.12086585
99MP0005167_abnormal_blood-brain_barrier1.11601857
100MP0000689_abnormal_spleen_morphology1.11155400
101MP0004510_myositis1.08872908
102MP0009764_decreased_sensitivity_to1.08749069
103MP0009053_abnormal_anal_canal1.07502516
104MP0002419_abnormal_innate_immunity1.07183722
105MP0004130_abnormal_muscle_cell1.06361725
106MP0008469_abnormal_protein_level1.06326618
107MP0004808_abnormal_hematopoietic_stem1.03629394
108MP0004019_abnormal_vitamin_homeostasis1.01558366
109MP0005330_cardiomyopathy0.98489397
110MP0005397_hematopoietic_system_phenotyp0.98167414
111MP0001545_abnormal_hematopoietic_system0.98167414
112MP0009763_increased_sensitivity_to0.95529301
113MP0001216_abnormal_epidermal_layer0.93753419
114MP0002429_abnormal_blood_cell0.93167443
115MP0002060_abnormal_skin_morphology0.92882974
116MP0000598_abnormal_liver_morphology0.90529871
117MP0005164_abnormal_response_to0.90361507
118MP0002136_abnormal_kidney_physiology0.89651413
119MP0005319_abnormal_enzyme/_coenzyme0.89548946
120MP0000367_abnormal_coat/_hair0.89540130
121MP0003868_abnormal_feces_composition0.87276450
122MP0005501_abnormal_skin_physiology0.87054956
123MP0003045_fibrosis0.86609610
124MP0000427_abnormal_hair_cycle0.86328905
125MP0002933_joint_inflammation0.81947245
126MP0000465_gastrointestinal_hemorrhage0.81747864
127MP0004043_abnormal_pH_regulation0.81600977
128MP0005451_abnormal_body_composition0.80346006
129MP0009765_abnormal_xenobiotic_induced0.80336070
130MP0001533_abnormal_skeleton_physiology0.76720625
131MP0003950_abnormal_plasma_membrane0.76614522
132MP0000858_altered_metastatic_potential0.76566270
133MP0005058_abnormal_lysosome_morphology0.76205303
134MP0004036_abnormal_muscle_relaxation0.76176999
135MP0005165_increased_susceptibility_to0.76146315
136MP0001879_abnormal_lymphatic_vessel0.75535147
137MP0004858_abnormal_nervous_system0.75395286
138MP0002148_abnormal_hypersensitivity_rea0.74509996
139MP0001191_abnormal_skin_condition0.73883839
140MP0000627_abnormal_mammary_gland0.72947908
141MP0000249_abnormal_blood_vessel0.72907750
142MP0000537_abnormal_urethra_morphology0.72200592
143MP0005584_abnormal_enzyme/coenzyme_acti0.71959832
144MP0001243_abnormal_dermal_layer0.71623182
145MP0002234_abnormal_pharynx_morphology0.70579043
146MP0001765_abnormal_ion_homeostasis0.68267059
147MP0000733_abnormal_muscle_development0.68082300
148MP0002896_abnormal_bone_mineralization0.66490064
149MP0004883_abnormal_blood_vessel0.65634661
150MP0004087_abnormal_muscle_fiber0.65156701
151MP0005166_decreased_susceptibility_to0.64895261
152MP0002998_abnormal_bone_remodeling0.63116341
153MP0010630_abnormal_cardiac_muscle0.63071113
154MP0005377_hearing/vestibular/ear_phenot0.62903226
155MP0003878_abnormal_ear_physiology0.62903226
156MP0002972_abnormal_cardiac_muscle0.58294899
157MP0003638_abnormal_response/metabolism_0.57220747
158MP0002332_abnormal_exercise_endurance0.56349770
159MP0000767_abnormal_smooth_muscle0.55779037

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)5.48558635
2Abnormality of nail color (HP:0100643)5.46766554
3Onycholysis (HP:0001806)4.78437842
4Fragile nails (HP:0001808)4.77415785
5Thick nail (HP:0001805)4.75710219
6Atrophic scars (HP:0001075)4.64719233
7T lymphocytopenia (HP:0005403)4.63698783
8Palmoplantar hyperkeratosis (HP:0000972)4.57692198
9Alopecia of scalp (HP:0002293)4.54356407
10Abnormality of T cell number (HP:0011839)4.46079194
11Deep venous thrombosis (HP:0002625)4.35221085
12Palmar hyperkeratosis (HP:0010765)4.22545584
13Pustule (HP:0200039)3.97952296
14Nail dystrophy (HP:0008404)3.96116785
15Xanthomatosis (HP:0000991)3.78577042
16Pili torti (HP:0003777)3.75295830
17Intrahepatic cholestasis (HP:0001406)3.73060093
18Abnormality of the nasal mucosa (HP:0000433)3.63874286
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60975198
20Autoimmune thrombocytopenia (HP:0001973)3.57704108
21Abnormal hair laboratory examination (HP:0003328)3.50563070
22Spontaneous hematomas (HP:0007420)3.49381830
23Abnormal blistering of the skin (HP:0008066)3.40298657
24Distal lower limb muscle weakness (HP:0009053)3.34476991
25Esophageal varix (HP:0002040)3.33085694
26Hyperlipoproteinemia (HP:0010980)3.32582733
27Lip pit (HP:0100267)3.32186777
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.27256509
29Nasal polyposis (HP:0100582)3.21220245
30Abnormality of the fingertips (HP:0001211)3.21152750
31Elevated erythrocyte sedimentation rate (HP:0003565)3.20329817
32Hypotrichosis (HP:0001006)3.20282934
33Joint hemorrhage (HP:0005261)3.16020648
34Myocardial infarction (HP:0001658)3.12027721
35Fragile skin (HP:0001030)3.08122784
36Complement deficiency (HP:0004431)3.03827037
37Chronic otitis media (HP:0000389)3.03217203
38Ridged nail (HP:0001807)3.03108901
39Abnormality of T cells (HP:0002843)2.98923143
40Abnormal platelet volume (HP:0011876)2.92638494
41Hypoplasia of dental enamel (HP:0006297)2.89774926
42Prolonged partial thromboplastin time (HP:0003645)2.88902608
43Recurrent fungal infections (HP:0002841)2.82601319
44Combined immunodeficiency (HP:0005387)2.81584193
45Abnormality of the salivary glands (HP:0010286)2.81019303
46Increased mean platelet volume (HP:0011877)2.80274791
47Hypobetalipoproteinemia (HP:0003563)2.80036233
48Woolly hair (HP:0002224)2.77587643
49Severe combined immunodeficiency (HP:0004430)2.74172448
50Polycythemia (HP:0001901)2.73446274
51Ventricular tachycardia (HP:0004756)2.73045539
52Recurrent viral infections (HP:0004429)2.70118382
53Stomatitis (HP:0010280)2.69197860
54Eczematoid dermatitis (HP:0000976)2.64816837
55Broad face (HP:0000283)2.63935935
56Distal lower limb amyotrophy (HP:0008944)2.63822795
57Natal tooth (HP:0000695)2.61800906
58Gingival bleeding (HP:0000225)2.61181867
59Pterygium (HP:0001059)2.61075635
60Abnormality of the common coagulation pathway (HP:0010990)2.58836815
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.56839404
62Popliteal pterygium (HP:0009756)2.55831542
63Increased connective tissue (HP:0009025)2.55376766
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51337587
65Panhypogammaglobulinemia (HP:0003139)2.50484749
66Hyperactive renin-angiotensin system (HP:0000841)2.49385798
67Hyperammonemia (HP:0001987)2.47524285
68Eosinophilia (HP:0001880)2.46492472
69Interstitial pulmonary disease (HP:0006530)2.45436401
70Corneal erosion (HP:0200020)2.45288265
71Advanced eruption of teeth (HP:0006288)2.44732138
72Epistaxis (HP:0000421)2.44652523
73Hypoplasia of the thymus (HP:0000778)2.43123480
74Obstructive sleep apnea (HP:0002870)2.42073870
75Joint swelling (HP:0001386)2.40457746
76Epidermoid cyst (HP:0200040)2.38365594
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36894846
78Menorrhagia (HP:0000132)2.35608467
79Abnormality of secondary sexual hair (HP:0009888)2.34792733
80Abnormality of the axillary hair (HP:0100134)2.34792733
81Sparse scalp hair (HP:0002209)2.34440265
82Hypercholesterolemia (HP:0003124)2.34098852
83Increased IgE level (HP:0003212)2.33230190
84Right ventricular cardiomyopathy (HP:0011663)2.32795313
85Flat acetabular roof (HP:0003180)2.32604972
86Palmoplantar keratoderma (HP:0000982)2.31477675
87Hematochezia (HP:0002573)2.30522401
88Ankyloglossia (HP:0010296)2.29752718
89Hypolipoproteinemia (HP:0010981)2.29356000
90Recurrent cutaneous fungal infections (HP:0011370)2.28905640
91Chronic mucocutaneous candidiasis (HP:0002728)2.28905640
92Selective tooth agenesis (HP:0001592)2.28092194
93Erythema (HP:0010783)2.27585068
94Hypoalphalipoproteinemia (HP:0003233)2.25289860
95Cerebral aneurysm (HP:0004944)2.25255364
96Prolonged bleeding time (HP:0003010)2.24647449
97Aortic aneurysm (HP:0004942)2.23998424
98Abnormality of complement system (HP:0005339)2.21882882
99Acanthosis nigricans (HP:0000956)2.21148311
100Mildly elevated creatine phosphokinase (HP:0008180)2.21070798
101Granulocytopenia (HP:0001913)2.19592240
102Oral leukoplakia (HP:0002745)2.19101263
103Aplasia cutis congenita (HP:0001057)2.18492657
104Hyporeflexia of lower limbs (HP:0002600)2.16127028
105Hyperglycinuria (HP:0003108)2.16011549
106Recurrent bronchitis (HP:0002837)2.15904390
107Exercise-induced myalgia (HP:0003738)2.15660511
108Axonal loss (HP:0003447)2.14206731
109Cervical subluxation (HP:0003308)2.13455069
110Fat malabsorption (HP:0002630)2.13178757
111Thin bony cortex (HP:0002753)2.13016625
112Milia (HP:0001056)2.12886346
113Abnormality of sulfur amino acid metabolism (HP:0004339)2.12803940
114Abnormality of eosinophils (HP:0001879)2.10521967
115Spastic diplegia (HP:0001264)2.09843884
116Hemorrhage of the eye (HP:0011885)2.09406935
117Ketosis (HP:0001946)2.06637952
118Hypoglycemic coma (HP:0001325)2.05623768
119Autoimmune hemolytic anemia (HP:0001890)2.02662509
120Broad metatarsal (HP:0001783)2.02103669
121Sparse eyelashes (HP:0000653)2.01396691
122Oligodontia (HP:0000677)2.01146794
123Ectopia lentis (HP:0001083)1.98902873
124Vascular calcification (HP:0004934)1.98537495
125Pulmonary embolism (HP:0002204)1.98449235
126Inflammation of the large intestine (HP:0002037)1.98389685
127Gout (HP:0001997)1.98385513
128Abnormality of serine family amino acid metabolism (HP:0010894)1.98305386
129Abnormality of glycine metabolism (HP:0010895)1.98305386
130Hepatitis (HP:0012115)1.95558688
131Ureteral stenosis (HP:0000071)1.95301589
132Abnormality of fatty-acid metabolism (HP:0004359)1.93957328
133Anonychia (HP:0001798)1.93551541
134Gastrointestinal inflammation (HP:0004386)1.93313632
135Hepatocellular carcinoma (HP:0001402)1.91895711
136Focal segmental glomerulosclerosis (HP:0000097)1.91605826
137Abnormality of the neuromuscular junction (HP:0003398)1.91161228
138Fatigable weakness (HP:0003473)1.91161228
139Leukocytosis (HP:0001974)1.90737086
140Congenital ichthyosiform erythroderma (HP:0007431)1.89630532
141Difficulty climbing stairs (HP:0003551)1.89265162
142Hypoplastic labia majora (HP:0000059)1.88955920
143Abnormal platelet function (HP:0011869)1.88153491
144Impaired platelet aggregation (HP:0003540)1.88153491
145Abnormality of purine metabolism (HP:0004352)1.87862724
146Frequent falls (HP:0002359)1.86996783
147Abnormality of the intrinsic pathway (HP:0010989)1.84963139
148Dry hair (HP:0011359)1.84539458
149Abnormality of oral frenula (HP:0000190)1.82584764
150Aneurysm (HP:0002617)1.82577448
151Sudden death (HP:0001699)1.82552245
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82158177
153Chronic diarrhea (HP:0002028)1.81699042
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80265658
155Upper limb amyotrophy (HP:0009129)1.78925720
156Distal upper limb amyotrophy (HP:0007149)1.78925720
157Cheilitis (HP:0100825)1.78187950
158Abnormality of T cell physiology (HP:0011840)1.78020556
159Cardiovascular calcification (HP:0011915)1.77778824
160Asymmetric septal hypertrophy (HP:0001670)1.77556999
161Mitral valve prolapse (HP:0001634)1.76970055
162Blepharitis (HP:0000498)1.76452664
163Neonatal death (HP:0003811)1.76387685
164Muscle fiber splitting (HP:0003555)1.75927872
165Bronchomalacia (HP:0002780)1.75067950
166Polygenic inheritance (HP:0010982)1.74746888
167Amelogenesis imperfecta (HP:0000705)1.74628432
168Abnormality of the labia majora (HP:0012881)1.74184079
169Malnutrition (HP:0004395)1.73154692
170Abnormality of nucleobase metabolism (HP:0010932)1.73103485
171Laryngomalacia (HP:0001601)1.73097688
172Conjunctival telangiectasia (HP:0000524)1.72873883
173Dehydration (HP:0001944)1.71675965
174Nephritis (HP:0000123)1.71383754
175Abnormality of permanent molar morphology (HP:0011071)1.71256209
176Abnormality of the dental root (HP:0006486)1.71256209
177Taurodontia (HP:0000679)1.71256209
178Short nail (HP:0001799)1.70115339
179Ectropion (HP:0000656)1.69488949
180Abnormality of the distal phalanges of the toes (HP:0010182)1.68737059
181Hyperkalemia (HP:0002153)1.68362132
182Glomerulosclerosis (HP:0000096)1.68151151
183Absent eyelashes (HP:0000561)1.67917668
184Arterial tortuosity (HP:0005116)1.64412750
185Systemic lupus erythematosus (HP:0002725)1.63328562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.10156554
2MAP4K13.59901193
3MET3.44118653
4PKN22.97128109
5TXK2.73408250
6TYK22.42324477
7STK102.34547916
8TGFBR22.32278481
9ITK2.30113495
10JAK32.23642532
11TIE12.22772681
12ZAP702.20709954
13FGFR32.17413645
14TTN2.17032716
15IKBKE2.11549707
16MAP3K62.06588624
17NLK2.04210267
18EEF2K1.99213929
19GRK61.96392617
20TRIB31.94207587
21MAP3K101.93102934
22MAPK151.77583533
23LMTK21.76758631
24EPHB21.75698029
25ERN11.73306697
26SIK11.67383769
27FLT31.66278820
28PRPF4B1.64703170
29JAK11.64335314
30EPHB11.64267363
31MAP3K141.62734806
32KDR1.57280610
33MAP3K131.49797078
34PTK61.46187781
35MAP3K71.44403838
36FGFR21.37979736
37SMG11.37227242
38TBK11.34515109
39LRRK21.31457862
40TEC1.30370376
41MAP3K21.30202250
42EPHA21.26102126
43CSK1.23539078
44MAP2K31.21339277
45FER1.19943121
46CDC42BPA1.18759891
47JAK21.12840374
48RIPK11.11080337
49LCK1.11052497
50PAK41.10676411
51MST41.08472937
52CDK121.07645603
53PRKCH1.06922711
54STK381.06905303
55NTRK11.06320327
56MYLK1.05400564
57HCK1.04378595
58EPHA31.04007642
59TGFBR11.03434563
60MAP3K30.97438724
61LATS20.94759150
62PDGFRB0.91689117
63PRKCQ0.90812987
64BTK0.90587637
65BMX0.88312019
66TRPM70.87104149
67ICK0.84695809
68CHUK0.84138871
69BCKDK0.83311243
70RPS6KA40.81200817
71PTK20.80948311
72IKBKB0.80189160
73MAP2K60.79471718
74MAP3K10.79217087
75MST1R0.78021295
76RPS6KB20.77910674
77MARK30.76745426
78RPS6KA20.75981110
79SIK30.73592809
80MAPK110.73423453
81MAPK70.73178752
82NME20.72014856
83MAPK120.71267607
84KIT0.70459688
85NME10.70299743
86SGK30.68266655
87MAP3K90.68188175
88PDGFRA0.68068563
89PIM10.66976037
90DMPK0.64598678
91PRKD20.64166554
92TYRO30.63239128
93CDK60.63138991
94PDPK10.63025341
95FGFR10.60614235
96TESK10.60154382
97CAMK1D0.58992322
98SIK20.56595227
99RPS6KL10.56472456
100RPS6KC10.56472456
101PRKAA20.56080187
102ERBB20.53247435
103MARK20.51981894
104PRKD10.49664709
105MTOR0.49179367
106TAOK30.48968340
107SYK0.48847645
108ARAF0.47916210
109NEK90.47227759
110MUSK0.45260499
111RET0.44840041
112PDK10.43125496
113DYRK1B0.42963170
114MAPKAPK30.40397209
115DDR20.40069129
116IRAK30.40021515
117PRKG20.39525249
118IRAK40.38538628
119PHKG10.38487667
120PHKG20.38487667
121STK40.38323437
122CAMK1G0.37970169
123CDK40.37425123
124STK240.37354900
125SGK20.36899136
126EGFR0.36264840
127HIPK20.36044585
128IGF1R0.35804605
129PIM20.35699230
130LATS10.35598861
131MAPK40.35265260
132TNK20.35058319
133TAOK10.34899373
134MAPKAPK20.33842334
135RPS6KA60.31914687
136STK38L0.31654762
137PTK2B0.31224862
138ABL20.30037093
139KSR20.29846989
140PRKCI0.29679002

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.15055256
2Primary immunodeficiency_Homo sapiens_hsa053402.79592989
3Nitrogen metabolism_Homo sapiens_hsa009102.62736732
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44178448
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32666641
6Fatty acid degradation_Homo sapiens_hsa000712.21873015
7Arginine biosynthesis_Homo sapiens_hsa002202.16854732
8Complement and coagulation cascades_Homo sapiens_hsa046102.15777314
9Tryptophan metabolism_Homo sapiens_hsa003802.00094823
10Caffeine metabolism_Homo sapiens_hsa002321.97897111
11Staphylococcus aureus infection_Homo sapiens_hsa051501.97497602
12T cell receptor signaling pathway_Homo sapiens_hsa046601.97400830
13Other glycan degradation_Homo sapiens_hsa005111.87914683
14PPAR signaling pathway_Homo sapiens_hsa033201.78628984
15Lysine degradation_Homo sapiens_hsa003101.65663187
16ABC transporters_Homo sapiens_hsa020101.63556937
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62077444
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60621955
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58448104
20Fatty acid metabolism_Homo sapiens_hsa012121.47236518
21Bile secretion_Homo sapiens_hsa049761.47051815
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46757705
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.41972323
24Chemical carcinogenesis_Homo sapiens_hsa052041.41286265
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40966603
26Histidine metabolism_Homo sapiens_hsa003401.38878972
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38015823
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36043783
29Peroxisome_Homo sapiens_hsa041461.28281392
30Measles_Homo sapiens_hsa051621.24303948
31Propanoate metabolism_Homo sapiens_hsa006401.21941220
32Dilated cardiomyopathy_Homo sapiens_hsa054141.20818545
33beta-Alanine metabolism_Homo sapiens_hsa004101.20011503
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19312303
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14158973
36GnRH signaling pathway_Homo sapiens_hsa049121.14091667
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13067876
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.12864547
39Linoleic acid metabolism_Homo sapiens_hsa005911.12628193
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.12186608
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12082509
42Retinol metabolism_Homo sapiens_hsa008301.11191868
43Acute myeloid leukemia_Homo sapiens_hsa052211.10833174
44Osteoclast differentiation_Homo sapiens_hsa043801.10468529
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.07895966
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07453159
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.05220251
48Fructose and mannose metabolism_Homo sapiens_hsa000511.04662361
49Insulin resistance_Homo sapiens_hsa049311.03964624
50Tight junction_Homo sapiens_hsa045301.03800511
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01590317
52Arachidonic acid metabolism_Homo sapiens_hsa005900.99991898
53Insulin signaling pathway_Homo sapiens_hsa049100.99938499
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.99291962
55Phenylalanine metabolism_Homo sapiens_hsa003600.99108939
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98823172
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98813930
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98369109
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98341931
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97628383
61Toxoplasmosis_Homo sapiens_hsa051450.96797236
62Selenocompound metabolism_Homo sapiens_hsa004500.95788794
63Prion diseases_Homo sapiens_hsa050200.95476951
64Glycerolipid metabolism_Homo sapiens_hsa005610.94157401
65Circadian rhythm_Homo sapiens_hsa047100.94024710
66Butanoate metabolism_Homo sapiens_hsa006500.93693722
67Bladder cancer_Homo sapiens_hsa052190.92631753
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.92607431
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.91853226
70Hematopoietic cell lineage_Homo sapiens_hsa046400.91315901
71Choline metabolism in cancer_Homo sapiens_hsa052310.90874488
72Fat digestion and absorption_Homo sapiens_hsa049750.89564316
73Inositol phosphate metabolism_Homo sapiens_hsa005620.87466009
74Hepatitis C_Homo sapiens_hsa051600.86865738
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.85102766
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.84913523
77Leishmaniasis_Homo sapiens_hsa051400.83833105
78Dorso-ventral axis formation_Homo sapiens_hsa043200.81521579
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81060319
80Renal cell carcinoma_Homo sapiens_hsa052110.78811499
81Pertussis_Homo sapiens_hsa051330.78398585
82Small cell lung cancer_Homo sapiens_hsa052220.78248604
83Antigen processing and presentation_Homo sapiens_hsa046120.77901513
84Starch and sucrose metabolism_Homo sapiens_hsa005000.77652332
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77562961
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.74450172
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72613775
88Galactose metabolism_Homo sapiens_hsa000520.72228104
89Endocytosis_Homo sapiens_hsa041440.72160702
90Viral myocarditis_Homo sapiens_hsa054160.72043920
91Ovarian steroidogenesis_Homo sapiens_hsa049130.71658286
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71616548
93ErbB signaling pathway_Homo sapiens_hsa040120.71185790
94Fatty acid biosynthesis_Homo sapiens_hsa000610.70711044
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69276411
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69214328
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68136372
98Pancreatic secretion_Homo sapiens_hsa049720.67529323
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67486026
100Protein digestion and absorption_Homo sapiens_hsa049740.66686621
101Adherens junction_Homo sapiens_hsa045200.65495863
102Influenza A_Homo sapiens_hsa051640.65466306
103Axon guidance_Homo sapiens_hsa043600.65115017
104Herpes simplex infection_Homo sapiens_hsa051680.64965223
105Sphingolipid metabolism_Homo sapiens_hsa006000.63813929
106Platelet activation_Homo sapiens_hsa046110.63594821
107Sulfur relay system_Homo sapiens_hsa041220.63562776
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63422057
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62242287
110Tyrosine metabolism_Homo sapiens_hsa003500.62206322
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.61776587
112Vitamin digestion and absorption_Homo sapiens_hsa049770.60989717
113TNF signaling pathway_Homo sapiens_hsa046680.59722551
114AMPK signaling pathway_Homo sapiens_hsa041520.59240387
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59101007
116Renin secretion_Homo sapiens_hsa049240.57743277
117Glucagon signaling pathway_Homo sapiens_hsa049220.55420193
118B cell receptor signaling pathway_Homo sapiens_hsa046620.54741993
119Chronic myeloid leukemia_Homo sapiens_hsa052200.54574112
120Pyruvate metabolism_Homo sapiens_hsa006200.54406322
121Pancreatic cancer_Homo sapiens_hsa052120.54171330
122Carbon metabolism_Homo sapiens_hsa012000.50498486
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50486032
124Mineral absorption_Homo sapiens_hsa049780.49953639
125Notch signaling pathway_Homo sapiens_hsa043300.49318053
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.49303687
127Arginine and proline metabolism_Homo sapiens_hsa003300.49284379
128Fatty acid elongation_Homo sapiens_hsa000620.49278815
129Hepatitis B_Homo sapiens_hsa051610.47763704
130Thyroid cancer_Homo sapiens_hsa052160.47689554
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47533477
132mTOR signaling pathway_Homo sapiens_hsa041500.47151304
133Lysosome_Homo sapiens_hsa041420.46777958
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46724408
135Pathways in cancer_Homo sapiens_hsa052000.46552523
136Ether lipid metabolism_Homo sapiens_hsa005650.44489991
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44281250
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43668958
139Biosynthesis of amino acids_Homo sapiens_hsa012300.43641961
140Rap1 signaling pathway_Homo sapiens_hsa040150.43393792
141Estrogen signaling pathway_Homo sapiens_hsa049150.42868020
142Folate biosynthesis_Homo sapiens_hsa007900.42798456
143Focal adhesion_Homo sapiens_hsa045100.42665901
144Prolactin signaling pathway_Homo sapiens_hsa049170.42627193
145ECM-receptor interaction_Homo sapiens_hsa045120.40151959
146Proteoglycans in cancer_Homo sapiens_hsa052050.39864072
147Apoptosis_Homo sapiens_hsa042100.38814991
148Endometrial cancer_Homo sapiens_hsa052130.38581084
149FoxO signaling pathway_Homo sapiens_hsa040680.37456147
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36520481
151Chemokine signaling pathway_Homo sapiens_hsa040620.36227351
152Amoebiasis_Homo sapiens_hsa051460.35219965
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34403193
154VEGF signaling pathway_Homo sapiens_hsa043700.32631329

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